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Плацентарная мезенхимальная дисплазия (ПМД) является редкой доброкачественной сосудистой аномалией плаценты с эхографической картиной, сходной с пузырным заносом, в виде плацентомегалии с множественными кистозными полостями. Представлен случай ПМД, диагностированный во втором триместре, с нормальным исходом беременности; приведена динамика эхографической картины на протяжении беременности; обсужден дифференциально-диагностический ряд и прогноз беременности. При проведении дифференциального диагноза кистозных изменений в плаценте, выявленных при УЗИ, следует помнить о редкой патологии — ПМД, при отсутствии высокоскоростных сигналов кровотока внутри зоны поражения и нормально сформированном плоде., Плацентарна мезенхімальна дисплазія (ПМД) є рідкісною доброякісною судинною аномалією плаценти з ехографічною картиною, подібною до міхурового занеску, у вигляді плацентомегалії з множинними кістозними порожнинами. Наведений випадок ПМД, діагностований у другому триместрі, з нормальним результатом вагітності; показано динаміку ехографічної картини протягом вагітності; обговорено диференційно-діагностичний ряд і прогноз вагітності. При проведенні диференціального діагнозу кістозних змін у плаценті, виявлених при УЗД, слід пам'ятати про рідкісну патологію — ПМД, за відсутності високошвидкісних сигналів кровотоку всередині зони ураження і при нормально сформованому плоді., Placental mesenchymal dysplasia (PMD) is a rare benign vascular anomaly of placenta, with an echographic pattern similar to a hydatidiform mole in the form of a placentomegaly with multiple cystic lesions. The case of diagnosed PMD in the second trimester with a normal pregnancy outcome is reported. The dynamics of the echographic pattern during pregnancy is presented, and the differential-diagnostic series and prognosis of pregnancy are discussed. When making a differential diagnosis of cystic changes in the placenta detected with ultrasound, the physisian should remember about a rare pathology as placental mesenchymal dysplasia, which featured the absence of high_speed signals of blood flow inside the affected area and a normally appearing fetus.

Aim: Women with pre-eclampsia (PE), placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) have been described as having placental permeability dysfunction. This study was performed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications and in women with non-reassuring fetal status. Methods: Forty-one antenatal and 39 postnatal blood samples were obtained from 46 women, including 11 with placental permeability dysfunction (5, 3, 2, and 1 with PE, PP, PA, and PMD, respectively) and 35 controls without such complications. To estimate the amount of fetal red blood cells, flow cytometry was performed using the fetal cell count system with two antibodies against fetal hemoglobin and carbonic anhydrase and the β-γ system with two monoclonal antibodies against hemoglobin β-chain and hemoglobin γ-chain. A diagnosis of FMH was made when the fraction size of the isolated cell population on scatter plots expressing fetal hemoglobin alone or hemoglobin γ-chain alone accounted for ≥ 0.02% of the total cell population on scatter plots. Results: FMH was identified in five women, including one each with PE, PA, PP, PMD, and no complications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4/11] vs 2.9% [1/35], respectively, P = 0.009). The FMH occurrence rate did not differ between women with and without non-reassuring fetal status (7.7% [1/13] vs 12% [4/33], respectively, P = 1.000). Conclusion :The risk of fetal red blood cells trafficking into the maternal circulation may be increased in women complicated with PE, PA, PP, and PMD.

Placental mesenchymal dysplasia is a rare benign condition complicating pregnancy. Fetus usually appears normal, with no significant abnormality. However association with Beckwith Wideman syndrome has been reported. Placenta often shows cystic areas in ultrasound and has to be differentiated from molar pregnancy. Placental villous chorangiosis is the hallmark of placental mesenchymal dysplasia.