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Ragul Paramasivam,1 Dhinakar Raj Gopal,2 Ranjithkumar Dhandapani,1 Ramalakshmi Subbarayalu,1 Mahesh Prabu Elangovan,1 Bhavadharani Prabhu,1 Veeramani Veerappan,1 Arunkumar Nandheeswaran,1 Siddarth Paramasivam,1 Saravanan Muthupandian3,4 1Research and Development Division, Chimertech Private Limited, Chennai, India; 2Department of Animal Biotechnology, Madras Veterinary College, Tamilnadu Veterinary and Animal Science University (TANUVAS), Chennai, 600007, India; 3AMR and Nanotherapeutics Lab, Centre for Transdisciplinary Research (CFTR), Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India; 4Division of Biomedical Science, College of Health Sciences, School of Medicine, Mekelle University, Mekelle, EthiopiaCorrespondence: Saravanan Muthupandian, Email bioinfosaran@gmail.comBackground: Bovine mastitis is the most frequent and costly illness impacting dairy herds worldwide. The presence of subclinical mastitis in dairy cows has an impact on the decreased output of milk and milk quality, culling of affected cows, mortality rate, as well as mastitis-related treatment expenses, generating significant financial loss to the dairy industry. The pathogenic bacteria invade through the mammary gland, which then multiply in the milk-producing tissues causing infection, and the presence of pathogenic bacteria in milk is concerning, jeopardizes human health, and also has public health consequences. Intervention to promote herd health is essential to protect public health and the economy.Results: This review attempts to provide an overview of subclinical mastitis, including mastitis in different species, the effect of mastitis on human health and its pathogenic mechanism, the prevalence and incidence of subclinical mastitis, and current preventive, diagnostic, and treatment methods for subclinical mastitis. It also elaborates on the management practices that should be followed by the farms to improve her