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Your search keyword '"Pan, Yunxiang"' showing total 4 results
Start Over Author "Pan, Yunxiang" Publication Type Electronic Resources
4 results on '"Pan, Yunxiang"'

1. GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system

Author

National Natural Science Foundation of China, National Basic Research Program (China), Shanghai Municipal Natural Science Foundation, Shanghai Science and Technology Committee, Shanghai Jiao Tong University, Zhang, Amin, Zhang, Qian, Alfranca, Gabriel, Pan, Shaojun, Huang, Zhicheng, Cheng, Jin, Ma, Qiang, Song, Jie, Pan, Yunxiang, Ni, Jian, Ma, Lijun, Cui, Daxiang, National Natural Science Foundation of China, National Basic Research Program (China), Shanghai Municipal Natural Science Foundation, Shanghai Science and Technology Committee, Shanghai Jiao Tong University, Zhang, Amin, Zhang, Qian, Alfranca, Gabriel, Pan, Shaojun, Huang, Zhicheng, Cheng, Jin, Ma, Qiang, Song, Jie, Pan, Yunxiang, Ni, Jian, Ma, Lijun, and Cui, Daxiang

Abstract

Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment. In this regard, we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic. The multifunctional probes consisted of a gold/platinum star-shaped core (Au/Pt star) conjugated with a GSH-sensitive disulfide bond (S–S), a targeting ligand (rHSA-FA), a near-infrared fluorophore (IR780) and glucose oxidase (GOx). When systemically administered in a xenografted murine model, the probes specifically targeted the tumor sites. As the disulfide linker was cleaved by intracellular GSH, the IR780 molecules could be released for photo-thermal therapy & photodynamic therapy (PTT&PDT) and imaging. Subsequently, the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system: GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity, and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic ·OH for tumor oxidative damage. Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release, real-time imaging ability, and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features, which provides a potential strategy for effective tumor theragnostic.

Published
2020

2. Photo-fenton-like metal–protein self-assemblies as multifunctional tumor theranostic agent

Author

National Natural Science Foundation of China, National Basic Research Program (China), National Key Research and Development Program (China), Shanghai Municipal Natural Science Foundation, Shanghai Science and Technology Committee, Shanghai Jiao Tong University, Li, Tianliang, Zhou, Jia, Wang, Lirui, Zhang, Hanfu, Song, Cunfeng, Fuente, Jesús M. de la, Pan, Yunxiang, Song, Jie, Zhang, Chunlei, Cui, Daxiang, National Natural Science Foundation of China, National Basic Research Program (China), National Key Research and Development Program (China), Shanghai Municipal Natural Science Foundation, Shanghai Science and Technology Committee, Shanghai Jiao Tong University, Li, Tianliang, Zhou, Jia, Wang, Lirui, Zhang, Hanfu, Song, Cunfeng, Fuente, Jesús M. de la, Pan, Yunxiang, Song, Jie, Zhang, Chunlei, and Cui, Daxiang

Abstract

Emerging Fenton‐like activity of copper ions has inspired great exploration for tumor microenvironment‐activated tumor therapy due to the toxic ·OH production for chemodynamic therapy and extra oxygen generation for photodynamic therapy (PDT). Still, the ·OH produced by copper ions is not satisfied even when copper ions are placed in a low pH environment (pH ≈ 5.0). To amplify its Fenton‐like activity, in this work, one kind of Cu2+–protein self‐assemblies (C‐m‐ABs) loaded with photosensitizer indocyanine green (ICG) is constructed, which can catalyze H2O2 generating more amounts of ·OH under light irradiation once Cu2+ is reduced to Cu+ by glutathione. Such fantastic phenomena confirms that C‐m‐ABs can act as a photo‐Fenton‐like agent. Furthermore, C‐m‐ABs can dramatically accelerate O2 generation (catalase activity) to enhance the PDT of ICG. After loading with the anticancer drug doxorubicin, C‐m‐ABs are further self‐assembled into novel nanobelts, which simultaneously exhibit superior photo‐heat conversion effects, enhanced r1 relaxation (21.416 s−1 mm−1) and stimuli‐responsive drug release behaviors. High cytotoxicity in vitro, effective tumor accumulation capacity observed by fluorescence/photoacoustic/magnetic resonance imaging, and enhanced chemo‐/photodynamic/photothermal therapeutic performance are achieved. Based on these results, a photo‐Fenton‐like metal–protein self‐assemblies demonstrate great potential for tumor theranostics.

Published
2019

3. A statistical analysis of circumstellar material in Type Ia supernovae

Author

Maguire, K., Sullivan, M., Patat, F., Gal-Yam, A., Hook, I. M., Dhawan, S., Howell, D. A., Mazzali, P., Nugent, P. E., Pan, Yunxiang, Podsiadlowski, P., Simon, J. D., Sternberg, A., Valenti, S., Baltay, C., Bersier, D., Blagorodnova, N., Chen, T. -W., Ellman, N., Feindt, U., Foerster, F., Fraser, M., Gonzalez-Gaitan, S., Graham, M. L., Gutierrez, C., Hachinger, S., Hadjiyska, E., Inserra, C., Knapic, C., Laher, R. R., Leloudas, G., Margheim, S., McKinnon, R., Molinaro, M., Morrell, N., Ofek, E. O., Rabinowitz, D., Rest, A., Sand, D., Smareglia, R., Smartt, S. J., Taddia, F., Walker, E. S., Walton, N. A., Maguire, K., Sullivan, M., Patat, F., Gal-Yam, A., Hook, I. M., Dhawan, S., Howell, D. A., Mazzali, P., Nugent, P. E., Pan, Yunxiang, Podsiadlowski, P., Simon, J. D., Sternberg, A., Valenti, S., Baltay, C., Bersier, D., Blagorodnova, N., Chen, T. -W., Ellman, N., Feindt, U., Foerster, F., Fraser, M., Gonzalez-Gaitan, S., Graham, M. L., Gutierrez, C., Hachinger, S., Hadjiyska, E., Inserra, C., Knapic, C., Laher, R. R., Leloudas, G., Margheim, S., McKinnon, R., Molinaro, M., Morrell, N., Ofek, E. O., Rabinowitz, D., Rest, A., Sand, D., Smareglia, R., Smartt, S. J., Taddia, F., Walker, E. S., and Walton, N. A.

Published
2013

4. A statistical analysis of circumstellar material in Type Ia supernovae

Author

Maguire, K., Sullivan, M., Patat, F., Gal-Yam, A., Hook, I. M., Dhawan, S., Howell, D. A., Mazzali, P., Nugent, P. E., Pan, Yunxiang, Podsiadlowski, P., Simon, J. D., Sternberg, A., Valenti, S., Baltay, C., Bersier, D., Blagorodnova, N., Chen, T. -W., Ellman, N., Feindt, U., Foerster, F., Fraser, M., Gonzalez-Gaitan, S., Graham, M. L., Gutierrez, C., Hachinger, S., Hadjiyska, E., Inserra, C., Knapic, C., Laher, R. R., Leloudas, G., Margheim, S., McKinnon, R., Molinaro, M., Morrell, N., Ofek, E. O., Rabinowitz, D., Rest, A., Sand, D., Smareglia, R., Smartt, S. J., Taddia, F., Walker, E. S., Walton, N. A., Maguire, K., Sullivan, M., Patat, F., Gal-Yam, A., Hook, I. M., Dhawan, S., Howell, D. A., Mazzali, P., Nugent, P. E., Pan, Yunxiang, Podsiadlowski, P., Simon, J. D., Sternberg, A., Valenti, S., Baltay, C., Bersier, D., Blagorodnova, N., Chen, T. -W., Ellman, N., Feindt, U., Foerster, F., Fraser, M., Gonzalez-Gaitan, S., Graham, M. L., Gutierrez, C., Hachinger, S., Hadjiyska, E., Inserra, C., Knapic, C., Laher, R. R., Leloudas, G., Margheim, S., McKinnon, R., Molinaro, M., Morrell, N., Ofek, E. O., Rabinowitz, D., Rest, A., Sand, D., Smareglia, R., Smartt, S. J., Taddia, F., Walker, E. S., and Walton, N. A.

Published
2013

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