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The New Haven Initiative for Excellence in Education is a private sector endeavor to support public schools in New Haven (Connecticut). The Initiative's premiere program is the Grants for Excellence program. Grants of up to $500 are available to teachers, administrators, and parents to fund special innovative teaching projects not normally funded by the school system budget. This document presents detailed descriptions of 77 such projects funded by the Initiative during the 1987-1988 school year, and covering the following areas of education: (1) special education; (2) primary; (3) middle; and (4) secondary. The following information is provided for each project: (1) description, including name of grant recipient, educational level, subject, number of students served, school, and project duration; (2) activities; (3) budget; (4) special equipment; (5) outcomes; and (6) comments from staff and/or students. Also included are an index of names; lists of 1987 and 1988 contributors; and lists of the project's staff, steering committee, and grant reviewers. (PB)

Despite their classical role as transcriptional repressors, several histone deacetylases, including the baker's yeast Set3/Hos2 complex (Set3C), facilitate gene expression. In the dimorphic human pathogen Candida albicans, the homologue of the Set3C inhibits the yeast-to-filament transition, but the precise molecular details of this function have remained elusive. Here, we use a combination of ChIP-Seq and RNA-Seq to show that the Set3C acts as a transcriptional co-factor of metabolic and morphogenesis-related genes in C. albicans. Binding of the Set3C correlates with gene expression during fungal morphogenesis; yet, surprisingly, deletion of SET3 leaves the steady-state expression level of most genes unchanged, both during exponential yeast-phase growth and during the yeast-filament transition. Fine temporal resolution of transcription in cells undergoing this transition revealed that the Set3C modulates transient expression changes of key morphogenesis-related genes. These include a transcription factor cluster comprising of NRG1, EFG1, BRG1, and TEC1, which form a regulatory circuit controlling hyphal differentiation. Set3C appears to restrict the factors by modulating their transcription kinetics, and the hyperfilamentous phenotype of SET3-deficient cells can be reverted by mutating the circuit factors. These results indicate that the chromatin status at coding regions represents a dynamic platform influencing transcription kinetics. Moreover, we suggest that transcription at the coding sequence can be transiently decoupled from potentially conflicting promoter information in dynamic environments.

Joan Flasch Artists' Book Collection

Joan Flasch Artists' Book Collection

Joan Flasch Artists' Book Collection

Dialectic Triangulation: A Visual Philosophy (Including the Human Argument), http://name.umdl.umich.edu/IC-UMMU-X-02-04098%5D02_04098, https://quod.lib.umich.edu/cgi/i/image/api/thumb/ummu/02-04098/02_04098/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. These materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Library Information Technology.; Publisher, https://www.lib.umich.edu/about-us/policies/copyright-policy