Search

Automatically detecting Alzheimer's Disease (AD) from spontaneous speech plays an important role in its early diagnosis. Recent approaches highly rely on the Transformer architectures due to its efficiency in modelling long-range context dependencies. However, the quadratic increase in computational complexity associated with self-attention and the length of audio poses a challenge when deploying such models on edge devices. In this context, we construct a novel framework, namely Hierarchical Attention-Free Transformer (HAFFormer), to better deal with long speech for AD detection. Specifically, we employ an attention-free module of Multi-Scale Depthwise Convolution to replace the self-attention and thus avoid the expensive computation, and a GELU-based Gated Linear Unit to replace the feedforward layer, aiming to automatically filter out the redundant information. Moreover, we design a hierarchical structure to force it to learn a variety of information grains, from the frame level to the dialogue level. By conducting extensive experiments on the ADReSS-M dataset, the introduced HAFFormer can achieve competitive results (82.6% accuracy) with other recent work, but with significant computational complexity and model size reduction compared to the standard Transformer. This shows the efficiency of HAFFormer in dealing with long audio for AD detection.

[Background] Two OxRisk risk assessment tools, the Oxford Mental Illness and Suicide (OxMIS) and the Oxford Mental Illness and Violence (OxMIV), were developed and validated using national linked registries in Sweden, to assess suicide and violence risk in individuals with severe mental illness (schizophrenia-spectrum disorders and bipolar disorders). In this study, we aim to examine the feasibility and acceptability of the tools in three different clinical services., [Method] We employed a two-step mixed-methods approach, by combining quantitative analyses of risk scores of 147 individual patients, and thematic analyses of qualitative data. First, 38 clinicians were asked to use OxMIS and OxMIV when conducting their routine risk assessments in patients with severe mental illness. The risk scores for each patient (which provide a probability of the outcome over 12 months) were then compared to the unstructured clinical risk assessment made by the treating clinician. Second, we carried out semi-structured interviews with the clinicians on the acceptability and utility of the tools. Thematic analysis was conducted on the qualitative data to identify common themes, in terms of the utility, accuracy, and acceptability of the tools. The investigations were undertaken in three general adult psychiatric clinics located in the cities of Barcelona and Sevilla (Spain), and Changsha (China)., [Results] Median risk probabilities over 12 months for OxMIS were 1.0% in the Spanish patient sample and 1.9% in the Chinese sample. For OxMIV, they were 0.7% (Spanish) and 0.8% (Chinese). In the thematic analysis, clinicians described the tools as easy to use, and thought that the risk score improved risk management. Potential additions to predictors were suggested, including family history and the patient's support network. Concordance rates of risk estimates between the tools and clinicians was high for violence (94.4%; 68/72) and moderate for suicide (50.0%; 36/72)., [Conclusion] Both OxMIS and OxMIV are feasible and practical in different general adult psychiatric settings. Clinicians interviewed found that both tools provide a useful structured approach to estimate the risk of suicide and violence. Risk scores from OxMIS and OxMIV can also be used to assist clinical decision-making for future management.

Chang Zhang,1,2 Lijuan Shi,3 Tong Tian,3 Ziwei Zhou,3 Xiyuan Peng,3 Yidong Shen,4 Yamin Li,1,2 Jianjun Ou4 1Xiangya Nursing School, Central South University, Changsha, China; 2Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, China; 3School of Education, Hunan University of Science and Technology, Xiangtan, China; 4National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaCorrespondence: Yamin Li; Jianjun Ou, The Second Xiangya Hospital of Central South University, No. 139 Renmin Road, Furong District, Changsha, 410011, People’s Republic of China, Tel +86-0731-85294072; +86 17775861486, Email aminny@csu.edu.cn; oujianjun@csu.edu.cnPurpose: Explore the potential mediating effects of anxiety symptoms and hopelessness on the relationship between academic stress and depressive symptoms among Chinese college students.Patients and Methods: A total of 1309 college students with informed consent were recruited from a local university in China. Academic stress, anxiety symptoms, hopelessness, and depressive symptoms were assessed by self-report scales. Haye’s PROCESS macro for SPSS was used to test the hypothesized mediation effect of anxiety symptoms and hopelessness in the relationship between academic stress and depressive symptoms.Results: Anxiety symptoms, hopelessness, and depressive symptoms were common among college students and were all significantly positively associated with academic stress levels. Academic stress could indirectly affect depressive symptoms by anxiety symptoms, hopelessness, and both anxiety symptoms and hopelessness. The total effect of academic stress on depressive symptoms was 0.063. The total effect of three indirect pathway was 0.039 which account for 62% of the total effect.Conclusion: The study detailed the specific process of depressive symptoms caused by academic stress in col

Chen Chen,1,2 Si Dai,2 Lijuan Shi,3 Yidong Shen,2 Jianjun Ou2 1Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai, Shanghai, People’s Republic of China; 2Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 3School of Education, Hunan University of Science and Technology, Xiangtan, Hunan, People’s Republic of ChinaCorrespondence: Jianjun OuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Furong District, Changsha, 410011, Hunan, People’s Republic of ChinaTel +86 17775861486Email oujianjun@csu.edu.cnPurpose: The mediating role of depressive symptoms and hopelessness on the relationship between attention deficit/hyperactivity disorder (ADHD) and internet gaming disorder (IGD) symptoms has not yet been elucidated. This study assessed this mediating effect in college students.Participants and Methods: Participants consisted of 1236 freshmen recruited at a local university. Symptoms of ADHD, IGD, depression and hopelessness were measured using self-report scales. The effect of ADHD on IGD mediated by depression and hopelessness was analyzed by Haye’s PROCESS macro for SPSS (Model 6) using the bias-corrected percentile bootstrap method with 5000 bootstrapped samples.Results: Symptoms of ADHD, depression and hopelessness were common in college students and were strongly associated with the appearance of IGD symptoms. ADHD symptoms of college students impacted their IGD symptoms directly and indirectly via depressive symptoms and hopelessness. The total effect

Most genes associated with neurodevelopmental disorders (NDDs) were identified with an excess of de novo mutations (DNMs) but the significance in case-control mutation burden analysis is unestablished. Here, we sequence 63 genes in 16,294 NDD cases and an additional 62 genes in 6,211 NDD cases. By combining these with published data, we assess a total of 125 genes in over 16,000 NDD cases and compare the mutation burden to nonpsychiatric controls from ExAC. We identify 48 genes (25 newly reported) showing significant burden of ultra-rare (MAF < 0.01%) gene-disruptive mutations (FDR 5%), six of which reach family-wise error rate (FWER) significance (p < 1.25E-06). Among these 125 targeted genes, we also reevaluate DNM excess in 17,426 NDD trios with 6,499 new autism trios. We identify 90 genes enriched for DNMs (FDR 5%; e.g., GABRG2 and UIMC1); of which, 61 reach FWER significance (p < 3.64E-07; e.g., CASZ1). In addition to doubling the number of patients for many NDD risk genes, we present phenotype-genotype correlations for seven risk genes (CTCF, HNRNPU, KCNQ3, ZBTB18, TCF12, SPEN, and LEO1) based on this large-scale targeted sequencing effort.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Jingping Zhao,1 Jianjun Ou,1 Haibo Xue,2 Li Liu,2 William Montgomery,3 Tamas Treuer4 1Mental Health Institute of The Second Xiangya Hospital, Hunan Province Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 2Lilly Suzhou Pharmaceutical Co, Ltd, Jiangsu, People's Republic of China; 3Global Health Outcomes, Eli Lilly and Company, Sydney, Australia; 4Emerging Markets Business Unit (Neuroscience), Eli Lilly and Company, Budapest, Hungary Abstract: The primary objective of this systematic review was to examine the evidence for the efficacy, effectiveness, and safety of orally disintegrating olanzapine in Chinese populations. A systematic literature search was conducted using databases covering international and Chinese journals, ClinicalTrials.gov, and internal and external trial registries at Eli Lilly and Company using search terms related to target countries (People's Republic of China, Hong Kong, and Taiwan) and orally disintegrating olanzapine treatment. A publication and one clinical study report were retrieved. The clinical study showed orally disintegrating olanzapine and the standard oral tablet to have similar efficacy and tolerability profiles. A bioequivalence study has shown that orally disintegrating olanzapine and the standard oral tablet have similar pharmacokinetic profiles. Orally disintegrating olanzapine and the standard oral tablet have similar efficacy and tolerability profiles. Keywords: orally disintegrating, olanzapine, Chinese, schizophrenia, patients