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BackgroundChordoma pathogenesis remains poorly understood. In this study, we aimed to evaluate the relationships between microRNA-155 (miR-155) expression and the clinicopathological features of chordoma patients, and to evaluate the functional role of miR-155 in chordoma.MethodsThe miRNA expression profiles were analyzed using miRNA microarray assays. Regulatory activity of miR-155 was assessed using bioinformatic tools. miR-155 expression levels were validated by reverse transcription-polymerase chain reaction. The relationships between miR-155 expression and the clinicopathological features of chordoma patients were analyzed. Proliferative, migratory and invasive activities were assessed by MTT, wound healing, and Matrigel invasion assays, respectively.ResultsThe miRNA microarray assay revealed miR-155 to be highly expressed and biologically active in chordoma. miR-155 expression in chordoma tissues was significantly elevated, and this expression correlated significantly with disease stage (p = 0.036) and the presence of metastasis (p = 0.035). miR-155 expression also correlated significantly with poor outcomes for chordoma patients (hazard ratio, 5.32; p = 0.045). Inhibition of miR-155 expression suppressed proliferation, and the migratory and invasive activities of chordoma cells.ConclusionsWe have shown miR-155 expression to independently affect prognosis in chordoma. These results collectively indicate that miR-155 expression may serve not only as a prognostic marker, but also as a potential therapeutic target in chordoma.

International Computer Music Conference Proceedings: vol. 2013, (dlps) bbp2372.2013.081, http://hdl.handle.net/2027/spo.bbp2372.2013.081, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 2012, (dlps) bbp2372.2012.020, http://hdl.handle.net/2027/spo.bbp2372.2012.020, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 2010, (dlps) bbp2372.2010.097, http://hdl.handle.net/2027/spo.bbp2372.2010.097, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 2009, (dlps) bbp2372.2009.002, http://hdl.handle.net/2027/spo.bbp2372.2009.002, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 2005, (dlps) bbp2372.2005.084, http://hdl.handle.net/2027/spo.bbp2372.2005.084, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 2004, (dlps) bbp2372.2004.089, http://hdl.handle.net/2027/spo.bbp2372.2004.089, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 2002, (dlps) bbp2372.2002.039, http://hdl.handle.net/2027/spo.bbp2372.2002.039, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 1999, (dlps) bbp2372.1999.437, http://hdl.handle.net/2027/spo.bbp2372.1999.437, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 1997, (dlps) bbp2372.1997.079, http://hdl.handle.net/2027/spo.bbp2372.1997.079, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.

International Computer Music Conference Proceedings: vol. 1995, (dlps) bbp2372.1995.119, http://hdl.handle.net/2027/spo.bbp2372.1995.119, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. Please contact mpub-help@umich.edu to use this work in a way not covered by the license.