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Communication through social media is a phenomenon whose relevance has involved the consideration of online discourse in the language teaching context. This article explores the functionality of Twitter (now called “X”) for science dissemination within the teaching and learning of English as a foreign language. To do this, 100 tweets from the accounts @WWF and @Greenpeace were gathered and analysed from the perspective of digital discourse analysis and communicative language teaching. I argue that using these tweets encourages the development of key competencies, provides room for the practice of integrated skills, and enhances the application of 21st-century skills. Conclusively, science dissemination tweets may be considered adequate for teaching and learning English.

Background: The GOG240 trial established bevacizumab with chemotherapy as standard first-line therapy for metastatic or recurrent cervical cancer. In the BEATcc trial (ENGOT-Cx10–GEICO 68-C–JGOG1084–GOG-3030), we aimed to evaluate the addition of an immune checkpoint inhibitor to this standard backbone. Methods: In this investigator-initiated, randomised, open-label, phase 3 trial, patients from 92 sites in Europe, Japan, and the USA with metastatic (stage IVB), persistent, or recurrent cervical cancer that was measurable, previously untreated, and not amenable to curative surgery or radiation were randomly assigned 1:1 to receive standard therapy (cisplatin 50 mg/m2 or carboplatin area under the curve of 5, paclitaxel 175 mg/m2, and bevacizumab 15 mg/kg, all on day 1 of every 3-week cycle) with or without atezolizumab 1200 mg. Treatment was continued until disease progression, unacceptable toxicity, patient withdrawal, or death. Stratification factors were previous concomitant chemoradiation (yes vs no), histology (squamous cell carcinoma vs adenocarcinoma including adenosquamous carcinoma), and platinum backbone (cisplatin vs carboplatin). Dual primary endpoints were investigator-assessed progression-free survival according to Response Evaluation Criteria in Solid Tumours version 1.1 and overall survival analysed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, NCT03556839, and is ongoing. Findings: Between Oct 8, 2018, and Aug 20, 2021, 410 of 519 patients assessed for eligibility were enrolled. Median progression-free survival was 13·7 months (95% CI 12·3–16·6) with atezolizumab and 10·4 months (9·7–11·7) with standard therapy (hazard ratio [HR]=0·62 [95% CI 0·49–0·78]; p<0·0001); at the interim overall survival analysis, median overall survival was 32·1 months (95% CI 25·3–36·8) versus 22·8 months (20·3–28·0), respectively (HR 0·68 [95% CI 0·52–0·88]; p=0·0046). Grade 3 or worse adverse events occurred in 79% of patient

Referencias bibliográficas • Alcaraz, F., P. Sánchez Gómez, A. De la Torre, S. Ríos, and J. Álvarez. 1991. Datos sobre la vegetación de Murcia. Guía Geobotánica de la Excursión de las XI Jornadas de Fitosociología. Promociones y Publicaciones Universitarias, S. A., 162 p. • Arnaiz, C. 1979. Ecología y fitosociología de los zarzales y espinales madrileños comprendidos en los sectores Guadarrámico, Manchego y Celtibérico-Alcarreño. Lazaroa 1: 129-38. • Asensi, A., and S. Rivas Martínez. 1979. Sobre la vegetación de Rhamno-Prunetea spinosae en Andalucía (España. Colloques Phytosociologia 8: 33-42. • Gómez Mercado, F., and F. Valle. 1988. Notas biogeográficas y ecológicas sobre el macizo de Cazorla-Segura: Las bojedas. Actes del Simposi Internacional de Botànica Pius Font i Quer, Vol II, 171-276. • Inocencio Pretel, C., F. Alcaraz, and S. Ríos. 1998. El paisaje vegetal de la Cuenca Albacetense del Guadalmena. Instituto de Estudios Albacetenses. Excma. Diputación. Provincial de Albacete. Serie I-Núm. 100, 327 p. • López, G. 1976. Contribución al conocimiento fitosociológico de la serranía de Cuenca I. Anales Institut Botanica Cavanilles 33: 5-87. • Martínez Parras, J. Ma, and J. Molero Mesa. 1982. Ecología y fitosociología de Quercus pyrenaica Willd. en la provincia Bética. Los melojares béticos y sus etapas de sustitución. Lazaroa 4: 91-104. • Martínez Parras, J.M.a, and J. Molero Mesa. 1983. Sobre la alianza Lonicero-Berberidion hispanicae O. de Bolòs, 1954, en la parte oriental de la provincia corológica Bética. Collectanea Botánica 14: 327-35. • Martínez Parras, J.M.a, M. Peinado, and F. Alcaraz. 1987. Comunidades vegetales de Sierra Nevada (España). Serv. Publ. Univ. Alcalá de Henares, 67 p. • Mota Poveda, J.F. 1990. Estudio Fitosociológico de las Altas Montañas Calcáreas de Andalucía (Provincia Corológica Bética). Tesis Doctoral. Univ. de Granada, 411 p. • Peinado, M., G. Moreno, and A. Velasco. 1983. Sur les boulaies lusoextremadurenses (Galio broteriani-Betuleto, This paper re-examines the Rhamno-Prunetea class in the centre and south of the Iberian Peninsula, especially in Andalusia. The paper also deals with the alliances Pruno-Rubion ulmifolii Lonicero-Berberidion hispanicae in the south of the Iberian Peninsula, and Berberidion vulgaris (Berberidenion seroi) in the area of Cuenca. Our analysis of 225 relevés arranged in 22 phytosociological tables helped us to re-organize the available information and subsequently propose three associations and two subassociations: Clematido vitalbae-Rosetum micranthae nova; Berberido hispanicae-Buxetum sempervirentis nova; Roso siculae-Berberidetum hispanicae Mota nova subas. prunetosum ramburii Mota nova; Lonicero arboreae-Rhamnetum cathartici Martínez-Parras and Molero Citation1983 subas. prunetosum ranburii nova. As a result of the study, a total of 18 syntaxa with the rank of association and four with the rank of subassociation are proposed for the south of the Iberian Peninsula., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

The article deals both with the Pinus occidentalis pine tree forests growing on high mountain limestones and siliceous substrates, and with the copses growing on serpentines in Dajabo´n (Cibao Valley), Dominican Republic. The samplings carried out in these forests reveal the occurrence of numerous endemic species and, consequently, the habitats can be considered as endemic, priority habitats of the Antilles. The article relies on some previous surveys carried out by us, Cano E, Velo´z Ramirez A, Cano-Ortiz A, Esteban FJ. (2009b). Analysis of the Pterocarpus officinalis forests in the Gran Estero (Dominican Republic). Acta Botanica Gallica 156(4):559–570, that made use of the data provided by 87 weather stations of the Dominican Republic. With the values of the Ci, Oi, Cti, etc. indexes, we make a bioclimatical proposal for Hispaniola. Our preliminary analysis of the studies published on the vegetation of the Island of Hispaniola and nearby islands, along with the samples taken by us, lead us to propose two new alliances: Ilici tuerckheimi–Pinion occidentalis and Phyllario mummularioidi–Leptogonion buchi, and three new associations: Dendropemon phycnophylli–Pinetum occidentalis, Cocotrino scopari–Pinetum occidentalis and Leptogono buchi–Pinetum occidentalis., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

Funding Este trabajo fue apoyado por las subvenciones RD16/0011/0012 y PI18/0371 a IG-A, y PI12/01578 a SC del Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) y cofinanciado por el Fondo Europeo de Desarrollo Regional. (FEDER). Actualmente, AT-M cuenta con una beca de doctorado de la Comunidad de Madrid (PEJD-2019-PRE/BMD-16851). Actualmente el NM se encuentra otorgado mediante RD16/0011/0012. El trabajo de ER-V cuenta actualmente con una subvención Rio-Hortega CM19/00149 del Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) y cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER)., Galectin 1 (Gal1) is a lectin with a wide cellular expression that functions as a negative regulator of the immune system in several animal models of autoimmune diseases. Identification of patients with rheumatoid arthritis (RA) has improved during the last decade, although there is still a need for biomarkers allowing an early diagnosis. In this regard, it has been recently proposed that Gal1 serum levels are increased in patients with RA compared to the general population. However, this topic is controversial in the literature. In this work, we provide additional information about the potential usefulness of Gal1 serum levels as a biomarker for RA diagnosis. We studied Gal1 serum and synovial fluid levels and clinical parameters in samples from 62 patients with early arthritis belonging to the PEARL study. In addition, 24 healthy donors were studied. We found that both patients fulfilling RA criteria and patients with undifferentiated arthritis showed higher Gal1 levels than healthy donors. Similar findings were observed in synovial fluid, which showed even higher levels than serum. However, we did not find correlation between Gal1 levels and disease activity or disability. Therefore, our results suggest that Gal1 could be a diagnostic but not a severity biomarker., Ministerio de Economía, Industria y Competitividad (MINECO), Instituto de Salud Carlos III (ISCIII) / FEDER, Comunidad de Madrid, Depto. de Biología Celular, Fac. de Ciencias Biológicas, TRUE, pub

Monthly, seasonal and annual trends in mean temperatures have been analysed in this study using data from 37 weather stations from the Pakistan Meteorological Department with records from 1952 to 2009. Statistical tests including Sen's slope and Mann‐Kendall were applied to each of the 37 stations in order to determine the sign and slopes of trends and their statistical significance. The study reveals that the temperature has generally increased in Pakistan at all time scales analysed over the past few decades. March and the pre‐monsoon season were the periods with the highest number of weather stations showing statistical significance, and also with the highest magnitudes of trends. Mean annual temperature increased around 0.36 °C/decade. This rise in temperature is slightly higher than other results found for Pakistan. The association between temperatures and certain teleconnection patterns, as well as the influence of the urban effect, might be among the causes of the trends found in this study. The largest number of correlations between mean temperatures and teleconnection patterns was found in March, April and May with NAO, ENSO and NCP, respectively. The North Atlantic Oscillation (NAO) may also have an influence on the temperatures of certain months in the monsoon season and particularly in August. At a seasonal resolution, NAO and NCP may control temperatures in the pre‐monsoon season. The lowest number of sites exhibiting correlations was found in winter and in the post‐monsoon seasons., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

The statistical and phytosociological study of 255 relevés taken in the south-west of the Iberian Peninsula and made up of our own samples and previous publications reveals how close these relevés, previously ascribed to different syntaxa, really are. Our re-arrangement of the data leads us to propose for the territory the 15 associations already pub lished and three new ones, namely: Genisto floridae-Adenocarpetum argyrophylli ass. nova hoc loco, Cytisetum bour gaei-eriocarpi nova, Lavandulo viridis-Cytisetum striati ass. nova hoc. loco. We also suggest a name correction, Adenocarpo anisochili-Cytisetum scoparii J.C. Costa et al. 2000 corr., and a status change, namely, Ulici latebracteati Cytisetum striati (Costa et al. 2000) status novo., L’étude statistique et phytosociologique de 255 inventaires du sud-ouest de la Péninsule Ibérique, de nos pro pres échantillonnages et des publications antérieures, fait voir la proximité entre les inventaires, qui auparavant ont été inclus dans des syntaxons différents. Nous avons réorganisé les données et maintenant nous proposons pour le térritoire 15 associations de celles qui ont été déjà publiées et en plus trois associations neuves: Genisto floridae-Adenocarpetum argyrophylli nova, Cytisetum bourgaei-eriocarpi nova, Lavandulo viridis-Cytisetum striati nova. Nous rectifions le nom Adenocarpo anisochili-Cytisetum scoparii J.C. Costa et al. 2000 corr., et nous changeons le status de Ulici latebracteati Cytisetum striati (Costa et al. 2000) status novo., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

This study reveals the occurrence of Phalaris coerulescens communities both in Portugal and the south of Andalusia (Spain). These grasslands present a variable cover ratio and have an average dominant vegetation size of about 100 cm. They tend to occur in river beds and in places which are sometimes water-logged, with a certain amount of organic matter inducing the occurrence of nitrophilous companion species. The soils are always siliceous, very poor in carbonates, but with a high proportion of sand. Consequently, flooding never lasts for long. The grasslands of Portugal are located in the Marianic Monchiquensean unit, within the series of Pyro bourgaeanae-Queceto rotundifoliae s. and Poterio agrimonioidis-Querceto suberis s. The new Senecio foliosi-Phalaridetum coerulescentis is characterized by Senecio jacobaea var foliosus, meanwhile, in the the south of Andalusia, the Hedysaro coronarii Phalaridetum coerulescentis is described for the Aljibic and Gaditan Onubensean Sectors, and, in the Rondean and Bermejensean areas, the Elymo repentis-Phalaridetum coerulescentis. These associations are included in the Gaudinio fragilis-Hordeion bulbosi alliance, Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

This paper, which deals with the geological history of Hispaniola in the general framework of Central America and particularly the Caribbean Sea, aims at revealing the influence of it on other areas. The paper studies the distribution of 675 species of Melastomataceae family, a family which has been used to establish the biogeographical ranges of Superprovince and biogeographical Province. The research also carried out a floristic and distributional study of 1.582 endemic species on Hispaniola. Nineteen working areas were defined and plant samples were taken in most of them following the Central European phytosociological method. With these datas, we plotted a map with the biogeographical Subprovinces and another one with the Sectors. The Superprovinces of Western Antilles, Central-Eastern Antilles have been established. This latter includes the Provinces of Eastern Antilles and Hispaniola. We propose a comprehensive biogeographical typology of the island. Due to its high endemicity and the great diversity of its habitats is moved to a upper range called biogeographical Province encompassing two Subprovinces: Central (one Sector) and Caribbean-Atlantic (Bahoruco-Hottense, Neiba-Metheux-Noroeste, Azua - San Juan - Hoya Henriquillo - Puerto Príncipe - Artiobonite - Gonaives, CaribbeanCibense and North)., Nous analysons ici l'histoire géologique de La Hispaniola, pour étudier l'influence de l'Amérique centrale et surtout de la Caraïbe par la distribution de 675 espèces de Melastomataceae, afin d’établir les rangs biogéographiques de sous-region, superprovince, province et sous-province. L’étude florístique et de la distribution de 1.582 plantes endémiques de La Hispaniola révèle finalement deux grandes régions. Nous avons fait l’inventaire de la végétation dans ces deux régions, en suivant la méthode phytosociologique européenne ; on en déduit deux sous-provinces. La haute endémicité et la grande diversité d'habitats justifient le rang de province, en distinguant deux sous-provincias : la Centrale (un seul secteur), la Caribéo-atlantique (avec les secteurs BahorucoHottense, Neiba-Metheux-Nord-Ouest, Azua - Sán Juán - Lac Henriquillo - Port Prince - Artiobonite - Gonaives, Caribéo-Cibense et Nord)., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

The Poa bulbosa communities present in the Iberian Peninsula are studied. With the aid of tables of associations provided by other authors and unpublished data, some statistical analyses (cluster analysis, Euclidean distance and PCA-analysis) were car ried out and a synthetic table was made to characterize the distinctive groups of taxa of each association. In both cases there are some rearrangements, which, together with the floristic and ecological study, lead us to propose the following novelties: Poetum ligu latae-bulbosae ass. nova hoc loco with a variant of Hieracium baeticum in the basophi lous communities, Festuco amplae-Poetum bulbosae plantaginetosum radica tae comb. nova for the silicicolous grasslands, and Plantaginenion serrariae stat. nov. (Tri folio sub te r ranei -Pe riballion ) for neutro-basophilous, vertic and siliceous soils., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

Résumé.- Nous avons étudié les communautés de Leptochloopsis virgata en République Dominicaine. Elles sont généralement dans des sites ombragés, comme dans le sud-ouest et la vallée de Cibao. Elles sont localisées généralement dans la sous-province Caribeo-Atlantique, sur marne à Cibao, Azua, Bani, Lac Enriquillo, et sur les serpentines de Port Argent. Le haut pourcentage d’endémicité et les biotopes créent un grand nombre d'habitats endémiques, de haute valeur écologique et géobotanique. Nous proposons dans ce travail deux nouvelles alliances et quatre associations ; au moins celles-ci possèdent un caractère endémique et devraient être considérées comme des habitats priori- taires pour la conservation, d’autant qu'elles sont localisées dans des régions influencées par l’homme, avec un risque d’extinction d'espèces, This paper deals with the Leptochloopsis virgata esparto patches growing in the Dominican Republic. These communities thrive mostly in shaded areas, as happens in the southwest of the island and the Cibao valley, where xericity records are high and vegetative inactivity lasts for over 7 months. The Leptochloopsis virgata esparto patches tend to be located in the Caribbean-Atlantic Subprovince, on the Quaternary marls of the Cibao valley, Azua, Bani, Lago Enriquillo, and on the serpentines of Puerto Plata, with an ombrotype ranging from semiarid to subhumid, but with a semiarid and dry character in the areas colonized by the espartillo and a thermotype which always remains infra-tropical. The high percentage of endemic species and media give rise to a high number of endemic, ecologically and geobotanically, highly valuable habitats. This paper suggests two new alliances and four associations. These latter, a least, present an endemic character and, consequently, should be considered as priority habitats for preservation purposes, since they are located in man-altered areas and the risk of species extinction cannot be ignored., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

This study analyzes the mean maximum and minimum temperature trends on a monthly, seasonal, and annual timescale by applying various statistical tools to data from 476 Spanish weather stations during the period between 1961 and 2006. The magnitude of the trends was derived from the slopes of the regression lines using the least squares method, and the nonparametric Mann–Kendall test was used to determine the statistical significance of the trends. Temperature significantly increased in over 60% of the country in March, June, spring, and summer in the case of maximum temperatures and in March, May, June, August, spring, and summer for minimum temperatures. At the annual resolution, temperatures significantly increased in over 90% of Spain with a rise of around 0.3°C/decade. The maximum temperature increased at a higher rate than the minimum temperature from midsummer to early winter as well as in winter, spring, and summer and also on an annual basis., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

Our soil study of the chromic soils located in the strip of land between Sierra Morena and the Guadalquivir Valley reveals a pH-value close to neutral in 25 samples. The pH-values are close to 5.5 only in the samples taken from the arenosols of the granitic batholith of Los Pedroches. However, it is the percentage of clay, sand and silt that explains the occurrence of grassland dominated by Raphanus raphanistrum, in the company of species with a psammophilous character such as Linaria spartea, Linaria amethystea and Brassica barrelieri. Our soil analysis reveals the presence of acid or base-poor soils. Consequently, the community of Raphanus raphanistrum found there displays an acidophilous, neutro-basophilous and subarenicolous character. Different types of sabulicolous plant communities appear as a result of the gradation of the soil texture. Since the Raphanus communities cannot be considered as genuinely sabulicolous, we have coined the term ‘subarenicolous’ to describe any plant community whose optimum sand content lies between 50% and 70%. The community of Linaria spartea and Raphanus rapha nistrum is neutro-basophilous and is found in at least the Marianic-Monchiquensean and North Hispalensean sectors. The floristic composition of the association is made up of Raphanus raphanistrum, Linaria spartea, Linaria amethystea, Medicago polymorpha, Hordeum leporinum, Bromus diandrus, Brassica barrelieri., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

This paper deals with the study of Taeniathero-Aegilopion geniculatae subnitrophilous communities found in the centre and south of Portugal, particularly in abandoned olive groves with vegetal cover. The edaphic and phytosociological study reveals that these pasturelands thrive on neutro-basic soils. In the corresponding dendrogram and in the co-location network, their peculiar floristic composition and, in particular, the co-existence of acidophilous and basophilous species give rise to a cluster of relevés distinctly separated from the rest. Consequently we propose the new Plantagini bellardii-Aegilopetum geniculatae association. It is different from the rest not only because of a number of differential species, but also for ecological reasons. In this respect, the edaphic analysis clearly reveals that all these samples correspond to soils with a pH value equal to or higher than 7, whereas the closest association, Trifolio cherleri-Taenitheretum capitis-medusae, presents a pH record below 7. There are also differences as far as the biogeographical unit and the vegetation series are concerned., Nous avons mené une étude des communautés subnitrophiles du Taeniathero-Aegilopion geniculatae dans le centre et le sud du Portugal dans les olivettes abandonnées végétalisées. L’étude édaphique et phytosociologique montre que ces pelouses croissent sur des sols neutro-basiques. Par la composition floristique caractéristique, dans le dendrogramme et dans la grille d’emplacement, se sépare des autres un groupe de relevés, séparation liée à la coexistence d’espèces acidophiles et basophiles. Par conséquent, nous proposons ici la nouvelle association Plantagini bellardii-Aegilopetum geniculatae, différente des autres par un ensemble d’espèces différentielles et par son écologie, puisque l’analyse édaphique montre que tous les relevés se trouvent dans des sols à pH égal ou supérieur à 7, tandis que l’association la plus proche, le Trifoliocherleri-Taenitheretum capitis-medusae, présente un pH inférieur à 7. Il y a aussi des différences phytogéographiques et dynamiques., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

The aim of this study is to know the diversity and state of conservation of the mangrove swamps of Central America. The study area is the State of Guerrero and the Dominican Republic and more precisely the sites of Tres Palos, Laguna de Coyuca, Majagua, Punta Arena (Sabana de la Mar), Barracote, Bahı´a de Samana´, Playa Las Cejas, Playa Moro´ n, Playa El Alema´n, Portillo, Laguna Redonda, Boca de Nisibo´ n, Playa del Macao, Laguna de Ba´varo, Punta Aljibe (Bahı´a Catalina), Isla Catalinita, Boca del Soco and Laguna de Oviedo. With the plant samples taken in the above mentioned sites, we created a synthetic table out of 16 phytosociological tables belonging to 6 original associations and 9 associations obtained from the bibliographical study. With the purpose of obtaining a similarity gradient (matching) between the associations under study, we carried out a statistical analysis (clustering, principal component analysis and Jaccard similarity/dissimilarity analysis). Our phytosociological approach relied on criteria such as biogreography and dynamic-catenal contact. Our sampling análisis has led us to propose the following syntaxa: Machaerio lunati-Rhizophoretum manglis; Rhabdadenio biflorae-Laguncularietum racemosae; Sthalio monospermae-Laguncularietum racemosae; Lonchocarpo pycnifolii-Conocarpetum erecatae; Lonchocarpo sericei Laguncularietum racemosae; Crataevo tapiae-Conocarpetum erectae. We also propose a new alliance and a change of status: Phyllantho elsiae-Laguncurion racemosae; Dalbergio-Rhizophorion manglis (Borhidi 1991) status novo. The mangrove swamps of Central America are arranged in three vegetation bands corresponding to different plant associations. The analysis of the three sampled area not only revealed the degradation of the vegetation but also the causative factors., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

Referencias bibliográficas: • Acevedo-Rodríguez, P., & Strong, M. T. (2008). Floristic richness and affinities in the West Indies. Botanical Review, 74, 5-36. doi: 10.1007/s12229-008-9000-1 • Addison, P. F. E., Rumpft, L., Ban, S. S., Carey, S. M., Chee, Y. E., Jarrad, F. C.,. Burgman, M. A. (2013). Practical solutions for making models indispensable in conservation decision-making. Diversity and Distributions, 19, 490-502. doi: 10.1111/ddi.12054 • Agrawal, A. (2009). Why "indigenous" knowledge? Journal of the Royal Society of New Zealand, 39, 157-158. doi: 10.1080/03014220909510569 • Aitken, S. (2012). The value of diversity. Biodiversity, 13, 1. doi: 10.1080/14888386.2012.666722 • Berkes, F. (2009). Indigenous ways of knowing and the study of environmental change. Journal of the Royal Society of New Zealand, 39, 151-156. doi: 10.1080/03014220909510568 • Borhidi, A. (1991). Phytogeography and vegetation ecology of Cuba. Nordic Journal of Botany, 12, 470. doi: 10.1111/j.1756-1051.1992.tb01330.x • Braun-Blanquet, J. (1979). Pflanzensoziologie: Grundzüge der Vegetationskunde. Madrid: Ed. Blume. • Cano, E., & Cano-Ortiz, A. (2012). Establishment of biogeographic areas by distributing endemic flora and habitats (Dominican Republic, Haiti R.). In L. Stevens (Ed.), Global Advances in Biogeography. (pp. 1-118) Croatia: Rijeka. doi: 10.5772/31591. Retrieved from http://www.intechopen.com/books/global-advances-inbiogeography/stablishmentof-biogeographicareas-by-distributing-endemic-flora-and-habitats. (accessed 16 September 2015). • Cano, E., Cano-Ortiz, A., Del Río, S., Veloz Ramirez, A., & Esteban Ruiz, F. J. (2014b). A phytosociological survey of some serpentine plant communities in the Dominican Republic. Plant Biosystems, 148, 200-212. doi: 10.1080/11263504.2012.760498 • Cano, E., Cano-Ortiz, A., Veloz Ramirez, A., Alatorre, J., & Otero, R. (2012). Comparative analysis between the mangrove swamps of the Caribbean and those of the State of Guerrero (Mexico). Plant Biosys, Nineteen areas on the island of Hispaniola (Haiti and the Dominican Republic) were studied with the aim of determining the distribution pattern of the endemic flora in these areas, and their variability with altitude. The main concentration of endemic species occurs in mountains with a medium altitude and in certain mountain sites (palaeo-islands), which coincide with hotspots; a lower number of endemics are found in low-lying areas (coldspots), due to the degradation of their habitats. A total of 1,582 endemic species were studied and were distributed in 19 areas. The whole island is of outstanding interest for its richness in endemics; it has 2,050 endemic species, representing 34.16% of its total flora. The territory in the study is home to 1,284 genera of which 31 are endemic to the island, including monotypical genera such as Tortuella abietifolia Urb. & Ekman, and endemic genera such as Hottea, containing seven endemic species. The sites with the highest rate of endemics are area A16 in the central range with a total of 440 endemic species, of which 278 are exclusive to the territory; and the Sierra de Bahoruco, la Selle, La Hotte and Tibur on in area A12, where we found 699 plants of which 482 are endemic and exclusive to the area; and A13 with 173 and 129 respectively. This work highlights the exceptional floristic diversity in endemic species and genera and analyses their distribution patterns as a tool for conservation in this area of the world, whose high endemicity rate makes it one of the most significant hotspots in the Caribbean., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

References: • García, R.; Mejía, M.; Peguero, B. Jiménez, F. Flora endémica de la sierra de Bahoruco, República Dominicana. Moscosoa 2001, 12, 9–44. • De Los Ángeles, I.; Clase, T.; Peguero, B. Flora y vegetación del Parque Nacional El Choco, Sosúa, provincia Puerto Plata, República Dominicana. Moscosoa 2005, 14, 10–55.. • Guerrero, A.; Jiménez, F.; Höner, D.; Zanoni, T. La flora y la vegetación de la loma Barbacoa, Cordillera Central, República Dominicana. Moscosoa 1997, 9, 84–116. • Höner, D.; Jiménez, F. Flora vascular y vegetación de la loma la Herradura (Cordillera Oriental), República Dominicana. Moscosoa 1994, 8, 65–85. • May, T. Regeneración de la Vegetación arbórea y arbustiva en un terreno de cultivos abandonado durante 12 años en la zona de bosques húmedos montanos (Reserva Científica Ébano Verde, Cordillera Central, República Dominicana). Moscosoa 1994, 8, 131–149. • May, T. Fases tempranas de la sucesión en un bosque nublado de Magnolia pallescens después de un incendio (Loma Casabito, Reserva Científica de Ebano Verde, Cordillera Central, República Dominicana). Moscosoa 1997, 9, 117–144. • May, T. Tres años de obervaciones fenológicas en el bosque nublado de Casabito (Reserva científica Ebano Verde, Cordillera Central, República Dominicana). Moscosoa 1998, 10, 164–178. • May, T. Respuesta de la vegeteción en un calimetal de Dicranopteris pectinata después de un fuego, en la parte oriental de la Cordillera Central, República Dominicana. Moscosoa 2000, 11, 113–132. • May, T. Composition, structure and diversity in broadleaved cloud forests in the Ebano Verde scientific reserve (Cordillera Central range, Dominican Republic). Moscosoa 2007, 15, 156–176. • May, T.; Peguero, B. Vegetación y flora de la loma el Mogote, Jarabacoa, Cordillera Central, República Dominicana. Moscosoa 2000, 11, 11–37. • Mejía, M.; García, R.; Jiménez, F. Sub-región fitogeográfica Barbacoa-Casabito: Riqueza florística y su importancia en la conservación de la flora de la isla Españ, The study of the forest in rainy environments of the Dominican Republic reveals the presence of four types of vegetation formations, clearly differentiated from each other in terms of their floristic and biogeographical composition, and also significantly different from the rainforests of Cuba. This leads us to propose two new alliances and four plant associations located in northern mountain areas exposed to moisture-laden winds from the Atlantic: All. Rondeletio ochraceae-Clusion roseae (Ass. Cyatheo furfuracei-Prestoetum motanae; Ass. Ormosio krugii-Prestoetum montanae); and All. Rondeletio ochraceae-Didymopanion tremuli (Ass. Hyeronimo montanae-Magnolietum pallescentis; Hyeronimo dominguensis-Magnolietum hamorii). We pay special attention to the description of cloud forest types, since they have a high rate of endemic species, and therefore there are endemic habitats, which need special protective actions. Therefore, we apply the Shannon diversity index to characteristic, companion, non-endemic, and endemic species. As result, the association Ormosio krugii-Prestoetum montanae has a Shannon_T = 2.4 and a value of Shannon_E = 0, whereas the other 3 associations have a better conservation status with Shannon values in all cases > 0: This is due to a worse conservation status of the Eastern Cordillera, in comparison with the Central Cordillera and Sierra de Bhaoruco. Due to human activity, some areas are very poorly conserved, as evidenced by the diversity index and the presence of endemic tree and plant elements. The worst conserved in terms of the relationship between characteristic plants vegetation (cloud forest) in areas with high rainfall are in the Dominican Republic, along with its floristic diversity and state of conservation. This study has made it possible to significantly increase the botanical knowledge of this important habitat., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

BackgroundAge-specific data on anal, and corresponding cervical, human papillomavirus (HPV) infection are needed to inform female anal cancer prevention.MethodsWe centrally reanalyzed individual-level data from 26 studies reporting HPV prevalence in paired anal and cervical samples by human immunodeficiency virus (HIV) status and age. For women with HIV (WWH) with anal high-grade squamous intraepithelial lesions or worse (HSIL+), we also investigated concurrent cervical cytopathology.ResultsIn HIV-negative women, HPV16 prevalence decreased significantly with age, both at anus (4.3% at 15-24 years to 1.0% at ≥55 years; ptrend = 0.0026) and cervix (7.4% to 1.7%; ptrend < 0.0001). In WWH, HPV16 prevalence decreased with age at cervix (18.3% to 7.2%; ptrend = 0.0035) but not anus (11.5% to 13.9%; ptrend = 0.5412). Given anal HPV16 positivity, concurrent cervical HPV16 positivity also decreased with age, both in HIV-negative women (ptrend = 0.0005) and WWH (ptrend = 0.0166). Among 48 WWH with HPV16-positive anal HSIL+, 27 (56%) were cervical high-risk HPV-positive, including 8 with cervical HPV16, and 5 were cervical HSIL+.ConclusionsAge-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections in the anus persist longer, or occur later in life, than in the cervix, particularly in WWH. This is an important consideration when assessing the utility of cervical screening results to stratify anal cancer risk.

BackgroundGlobal brain health initiatives call for improving methods for the diagnosis of Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented populations. However, diagnostic procedures in upper-middle-income countries (UMICs) and lower-middle income countries (LMICs), such as Latin American countries (LAC), face multiple challenges. These include the heterogeneity in diagnostic methods, lack of clinical harmonisation, and limited access to biomarkers.MethodsThis cross-sectional observational study aimed to identify the best combination of predictors to discriminate between AD and FTD using demographic, clinical and cognitive data among 1794 participants [904 diagnosed with AD, 282 diagnosed with FTD, and 606 healthy controls (HCs)] collected in 11 clinical centres across five LAC (ReDLat cohort).FindingsA fully automated computational approach included classical statistical methods, support vector machine procedures, and machine learning techniques (random forest and sequential feature selection procedures). Results demonstrated an accurate classification of patients with AD and FTD and HCs. A machine learning model produced the best values to differentiate AD from FTD patients with an accuracy = 0.91. The top features included social cognition, neuropsychiatric symptoms, executive functioning performance, and cognitive screening; with secondary contributions from age, educational attainment, and sex.InterpretationResults demonstrate that data-driven techniques applied in archival clinical datasets could enhance diagnostic procedures in regions with limited resources. These results also suggest specific fine-grained cognitive and behavioural measures may aid in the diagnosis of AD and FTD in LAC. Moreover, our results highlight an opportunity for harmonisation of clinical tools for dementia diagnosis in the region.FundingThis work was supported by the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat), funded b

Spondyloarthritis (SpA) is a family of inflammatory diseases sharing clinical, genetic, and radiological features. While crucial for tailoring early interventions, validated prognostic biomarkers are scarce in SpA. We analyze the correlation between serum levels of vasoactive intestinal peptide (VIP) and disease activity/severity in patients with early chronic inflammatory back pain. The study population comprised 54 patients enrolled in our early chronic inflammatory back pain register. We collected demographic information, clinical data, laboratory data, and imaging findings. VIP levels were measured by enzyme immunoassay in serum samples from 162 visits. The association between independent variables and VIP levels was analyzed using longitudinal multivariate analysis nested by patient and visit. No significant differences were observed in VIP levels between these two groups. Lower levels of VIP were significantly associated with a higher Bath Ankylosing Spondylitis Disease Activity Index (BASFI) score, presence of bone edema in magnetic resonance imaging (MRI) scan, and lower hemoglobin levels. Coexistence of cutaneous psoriasis was independently associated with lower VIP levels, and similar trend was observed for enthesitis.We conclude that SpA patients with low serum VIP levels had worse 2-year disease outcome, suggesting that, Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, FEDER funds, from UCM-BSCH, and S2010/BMD-2350 from Comunidad de Madrid., Depto. de Biología Celular, Fac. de Ciencias Biológicas, TRUE, pub

[Resumen] ANTECEDENTES: La infección bronquial crónica supone la principal causa de morbimortalidad en los pacientes con fibrosis quística. El agente responsable que se objetiva mayoritariamente es la Pseudomona Aeruginosa. El deterioro clínico que supone su infección, el aumento de exacerbaciones y de mortalidad, requiere un tratamiento continuo y a largo plazo para su adecuado control clínico. El surgimiento de cada vez más resistencias antimicrobianas frente a los antibióticos que se vienen utilizando, crea la necesidad de nuevos tratamientos antibióticos, así como pautas de utilización/rotación de fármacos novedosas, que nos aporten un mayor número de herramientas para el control de la patología. OBJETIVO: Estudiar si existe diferencia, a nivel de función pulmonar, entre el uso de amikacina inhalada y la tobramicina inhalada en la infección bronquial crónica por Pseudomona Aeruginosa en pacientes con fibrosis quística. METOLOGIA: Estudio de tipo experimental, analítico, longitudinal, prospectivo, controlado, aleatorizado y doble ciego. Un grupo intervención (pacientes con infección bronquial crónica por PA que recibirán amikacina inhalada) y un grupo control (pacientes con infección bronquial crónica por PA que recibirán tobramicina inhalada) con una muestra de 151 pacientes en cada grupo. APLICABILIDAD: El uso de amikacina inhalada en la infección bronquial crónica por PA en FQ supondría una mayor disponibilidad de tratamiento y la posibilidad de plantear nuevas pautas/rotaciones y optimizar el manejo clínico para permitir reducir las exacerbaciones, mejorar la calidad de vida y disminuir la mortalidad., [Abstract] BACKGROUND: Chronic bronchial infection is the main cause of morbidity and mortality in patients with cystic fibrosis. The responsible agent that is mostly objectified is Pseudomonas Aeruginosa. The clinical deterioration caused by its infection, the increase in exacerbations and mortality, requires continuous and long-term treatment for adequate clinical control. The emergence of more and more antimicrobial resistance against the antibiotics that have been used, creates the need for new antibiotic treatments, as well as guidelines for the use/rotation of novel drugs, which provide us with a greater number of tools for the control of the pathology. OBJECTIVE: To study whether there is a difference, at the level of lung function, between the use of inhaled amikacin and inhaled tobramycin in chronic bronchial infection by Pseudomonas Aeruginosa in patients with cystic fibrosis. METHOLOGY: Experimental, analytical, longitudinal, prospective, controlled, randomized, double-blind study. An intervention group (patients with chronic bronchial infection by PA who will receive inhaled amikacin) and a control group (patients with chronic bronchial infection by PA who will receive inhaled tobramycin) with a sample of 151 patients per group. APPLICABILITY: The use of inhaled amikacin in chronic bronchial infection by PA in CF would mean greater availability of treatment and the possibility of proposing new regimens/rotations and optimizing clinical management to reduce exacerbations, improve quality of life and decrease the risk of death. mortality., [Resumo] ANTECEDENTES: A infección bronquial crónica é a principal causa de morbilidade e mortalidade en pacientes con fibrose quística. O axente responsable que se obxectiva maioritariamente a Pseudomonas Aeruginosa. O deterioro clínico provocado pola súa infección, o aumento das exacerbacións e da mortalidade, require un tratamento continuo e a longo prazo para un adecuado control clínico. A aparición de cada vez máis resistencias antimicrobianas fronte aos antibióticos que se foron empregando, xera a necesidade de novos tratamentos antibióticos, así como de pautas de uso/rotación de novos fármacos, que nos proporcionan un maior número de ferramentas para o control de a patoloxía. OBXECTIVO: Estudar se existe diferenza, a nivel de función pulmonar, entre o uso de amikacina inhalada e tobramicina inhalada na infección bronquial crónica por Pseudomonas aeruginosa en pacientes con fibrose quística. METODOLOXÍA: Estudo experimental, analítico, lonxitudinal, prospectivo, controlado, aleatorizado, dobre cego. Un grupo de intervención (pacientes con infección bronquial crónica por PA que recibirán amikacina inhalada) e un grupo control (pacientes con infección bronquial crónica por PA que recibirán tobramicina inhalada) cunha mostra de 151 pacientes en cada grupo. APLICABILIDADE: O uso da amikacina inhalada na infección bronquial crónica por AP na FQ suporía unha maior dispoñibilidade de tratamento e a posibilidade de propoñer novos réximes/rotacións e optimizar o manexo clínico para reducir as exacerbacións, mellorar a calidade de vida e diminuír o risco de morte.

Cellular Retinoic Acid Binding Protein-1 (CRABP1) facilitates retinoid metabolism; however, an abnormal expression might influence cancers developed. Biopsy samples were evaluated from patients with cervical cancer (CC), high-grade (HSIL), and low-grade squamous intraepithelial lesions (LSIL) (n= 66) Clinic/pathological information was obtained from patients. CRABP1 gene expression was examined by RT-PCR and CRABP1 protein by immunohistochemistry (IHC) techniques. The expression of the CRABP1 gene is shown to be significantly lower in the HSIL group (p= 0.008). CRABP1 protein was expressed in 90.3% of tissues, and only in CC was presented absence of protein (9.7%). Overweight/obesity might increase the gene (p= 0.019) but not the protein expression (p= 0.053). Also, a gene expression increase was shown in high serum retinol concentration (p= 0.047) and the presence of HVP-16 (p= 0.011) (gene expression but not the protein, p > 0.05). Menopause patients were associated with an absent/weak CRABP1 immunostaining (p= 0.008). Finally, CRABP1 and associated factors might be used as biomarkers to track the progression and persistence of cervical cancer on tissue., La unión celular de la proteína con el ácido retinoico-1 (CRABP1) facilita el metabolismo de los retinoides y de su expresión anormal podría resultar en diversos cánceres. Para el caso que nos ocupa se evaluaron muestras de las biopsias de pacientes con cáncer de cuello uterino (CC) y con lesiones intraepiteliales escamosas de alto (HSIL) y de bajo grado (LSIL) (n= 66), por lo que para realizar el estudio se obtuvo la información clínico-patológica de las mujeres. La expresión del gen CRABP1 se examinó mediante RT-PCR y la proteína por inmunohistoquímica (IHC). La expresión de CRABP1 resultó ser más baja en el grupo HSIL significativamente (p = 0.008). La expresión proteica de CRABP1 se observó en el 90.3% de los tejidos, y en el CC su ausencia fue de un 9.7%. El aumento de la expresión génica, así como la disminución de la cantidad de proteína en este tipo de cáncer varía en diferentes situaciones médicas de acuerdo a lo observado: en el sobrepeso/obesidad aumenta la expresión génica (p= 0.019), pero no en la proteína (p = 0.053). Además, se mostró un aumento de la expresión CRABP1 con una concentración alta de retinol (p= 0.047) y la presencia de HVP-16 (p= 0.011) (expresión génica pero no la proteína, p > 0.05). Pacientes con menopausia se asociaron con la ausencia/débil inmunotinción de la proteína CRABP1 (p= 0.008). Finalmente, concluimos que CRABP1 y los factores asociados pueden ser útiles como biomarcadores para rastrear la progresión y la persistencia del cáncer de cuello uterino en el tejido.

OBJECTIVE: Cognitive-behavioral therapy (CBT) is considered a first-line treatment for obsessive-compulsive disorder (OCD) in pediatric and adult populations. Nevertheless, some patients show partial or null response. The identification of predictors of CBT response may improve clinical management of patients with OCD. Here, we aimed to identify structural magnetic resonance imaging (MRI) predictors of CBT response in 2 large series of children and adults with OCD from the worldwide ENIGMA-OCD consortium. METHOD: Data from 16 datasets from 13 international sites were included in the study. We assessed which variations in baseline cortical thickness, cortical surface area, and subcortical volume predicted response to CBT (percentage of baseline to post-treatment symptom reduction) in 2 samples totaling 168 children and adolescents (age range 5-17.5 years) and 318 adult patients (age range 18-63 years) with OCD. Mixed linear models with random intercept were used to account for potential cross-site differences in imaging values. RESULTS: Significant results were observed exclusively in the pediatric sample. Right prefrontal cortex thickness was positively associated with the percentage of CBT response. In a post hoc analysis, we observed that the specific changes accounting for this relationship were a higher thickness of the frontal pole and the rostral middle frontal gyrus. We observed no significant effects of age, sex, or medication on our findings. CONCLUSION: Higher cortical thickness in specific right prefrontal cortex regions may be important for CBT response in children with OCD. Our findings suggest that the right prefrontal cortex plays a relevant role in the mechanisms of action of CBT in children.

This study identifies and analyzes the plant communities that allow the definition of the geographic limits between Temperate and Mediterranean macrobioclimates, for the center of Portuguese mainland. The altitude of Serra da Estrela, Açor and Lousã, combined with the increase in atmospheric humidity, allows the presence of vegetation typical of a Temperate macrobioclimate. Thus, based on the phytosociological methodology, floristic relevés were carried out in order to identify the series of vegetation existing in these territories. Through these relevés carried out, four new plant associations were identified: Cytisetum grandifloro-striati ass. nova, Scrophulario grandiflorae-Sambucetum nigrae ass. nova, Pruno lusitanicae-Coryletum avellanae ass. nova that lives in the submediterranean bioclimatic variant, mesotemperate humid to hyper-humid. A new association namely Genisto falcatae-Quercetum broteroanae ass. nova with two subassociations were also identified. Based on the vegetation distribution, new biogeographic limits are proposed. Thus, it was intended to identify the southern limits of the European Atlantic Province (Atlantic Orolusitania Subrovince) based on the vegetation cover, namely the distinction between the Estrela Sierran District and a new Biogeographical District, the Alvo-Gardunhense.

Treball Final MBArch - Màster Universitari en Estudis Avançats en Arquitectura-Barcelona: Arquitectura, Energia i Medi Ambient, Este trabajo de investigación cuantifica el calor antropogénico generado por el transporte y el aporte que tiene a la isla urbana de calor en diferentes morfologías urbanas en la ciudad de Barcelona. El trabajo se ha realizado teniendo en cuenta el calor desprendido por distintos tipos de vehículos (coches, motos, autobuses) y el flujo de tráfico diario en calles representativas de diferentes barrios, con la finalidad de cuantificar el calor antropogénico del transporte generado en cuatro barrios de Barcelona. El calor antropogénico del transporte generado en cada barrio se ha analizado en relación a diferentes parámetros de morfología urbana. La comparación ha revelado que existe una fuerte relación entre la densidad de la malla de calles (N) de un barrio y el calor antropogénico del transporte. Por lo tanto, esta relación se podría aplicar a estudios de isla urbana de calor para estimar el calor antropogénico del transporte en cualquier barrio a partir de simples parámetros morfológicos., This research work quantifies the anthropogenic heat generated by transportation and the contribution it has to the urban heat island in different urban morphologies in the city of Barcelona. The work has been carried out taking into account the heat given off by different types of vehicles (cars, motorcycles, buses) and the daily traffic flow in representative streets of different neighborhoods, with the aim of quantifying the anthropogenic heat generated by transportation in four neighborhoods of Barcelona. The anthropogenic heat from transportation generated in each neighborhood has been analyzed in relation to different parameters of urban morphology. The comparison has revealed that there is a strong relationship between the network density (N) in a neighborhood and the anthropogenic heat from transportation. Therefore, this relationship could be applied to urban heat island studies to estimate the anthropogenic heat from transportation in any neighborhood from simple morphological parameters., Award-winning

Hay dos conceptos que en sus respectivos campos de estudio adquieren cada día mayor fuerza, por su relevancia, por las respuestas que ofrecen en sus campos y los desafíos a los que como sociedad nos enfrentamos, estos son, la restauración ecológica y la empresa social, el primero más cercano a las ciencias naturales, especialmente a la ecología, y el segundo a las ciencias de la administración y las teorías del desarrollo, especialmente del desarrollo endógeno, con esta investigación nos acercamos a una intercepción que nos muestra las oportunidades que brinda el hacer un estudio conjunto de los mismos. La crisis climática que afrontamos es el desafío de nuestra generación, como afirma Bill Ney (2017), el divulgador científico Estadounidense, que entre comedia y seriedad, establece que si la generación de nuestros padres fue capaz de resolver la segunda guerra mundial, es nuestra responsabilidad encontrar solución a la crisis climática que nos enfrentamos, la cual no solo trae el cambio climático y el aumento de la temperatura, sino la pérdida de la biodiversidad, y con esta en riesgo de la cultura, de la diversidad biocultural, y de aquí nace la idea de analizar esas relaciones actuales entre los agricutlores y los ecosistemas que habitan, así como las apuestas de un tipo de empresas, sociales, que nacen con la finalidad de aportar su grano de arena contra la crisis climática en la región del Piedemonte Llanero, el cual por sus características únicas, lo hace una subregión propicia para la creación de empresas sociales que tengan como su eje central la restauración ecológica, la regeneración de los suelos y la conservación de la Biocultura. De este análisis y reflexión sobre la bioculturalidad, la relación con los ecosistemas, y la existencia de empresas sociales, se busca plantear un modelo de construcción de empresas sociales que permita a las comunidades de esta región generar oportunidades de crecimiento, desarrollo social y económico, pero especialmente de res

In this study the enrichment dietary effect with different crude protein levels (CP) and feed additives on growth, survival, feed conversion ratio (FCR), feed consumption (FC) and total hemocyte count (THC) in juvenile white shrimp Litopenaeus vannamei were evaluated. The study covered two bioassays: in the first one, juveniles were daily fed for 45 days with four experimental diets containing: (1) Control, commercial feed (35% CP); (2) 29% CP; (3) 32% CP; (4) 35% CP. After the 29% CP diet was selected, juveniles in bioassay II were daily fed for 45 days with a single CP diet complemented with probiotics: (1) Control, commercial feed (35% CP); (2) 29% CP; (3) 29% CP + Bacillus mix at 1×106 CFUg-1 feed; and (4) 29% CP + yeast mix at 1×106 CFUg-1 feed. Juvenile shrimp fed with experimental diets gained significantly more weight and increased survival, FCR, FC and THC compared with control diet. However, differences among experimental diets were not significant. In bioassay II, juvenile shrimp fed with experimental diet + feed additives significantly increased survival, FCR, FC and THC compared with control diet. Growth of juveniles significantly increased with 29% CP and 29% CP + yeast mix diets, compared with control group. Complementing the diet with yeast mix showed higher survival and THC of juveniles compared with the other experimental treatments. Different CP levels in shrimp diet improved growth, survival and circulating hemocytes, and addition of mixed yeast as feed additive induced better survival and immune response in juvenile shrimp., Resumen: En este estudio se evaluó el efecto del enriquecimiento de dietas con diferentes niveles de proteína cruda (CP) y aditivos en el crecimiento, supervivencia, tasa de conversión alimenticia (FCR), consumo de alimento (FC) y conteo total de hemocitos (THC) en juveniles de camarón blanco Litopenaeus vannamei. El estudio consta de dos bioensayos: en el primero, los juveniles fueron alimentados diariamente por 45 días con cuatro dietas experimentales con diferente contenido de proteína: (1) Alimento comercial o control, CP 35%; (2) CP 29%; (3) CP 32%; (4) CP 35%. Después de seleccionar CP 29%, en el bioensayo II los juveniles fueron alimentados diariamente por 45 días con una dieta proteica complementada con probióticos: (1) Alimento comercial o control, CP 35%; (2) CP 29%; (3) CP 29% + mezcla de Bacillus a 1×106 UFCg-1 alimento; y (4) CP 29% + mezcla de levaduras a 1×106 UFCg-1 alimento. Los camarones juveniles alimentados con las dietas experimentales mostraron ganancia en peso significativamente mayor e incremento en supervivencia, FCR, FC y THC comparado con la dieta control. Sin embargo, no hubo diferencias significativas entre las dietas experimentales. En el segundo bioensayo, los juveniles alimentados con la dieta experimental + aditivos alimentarios incrementaron significativamente supervivencia, FCR, FC y THC comparado con la dieta control. El crecimiento de juveniles se incrementó significativamente con las dietas CP29% y CP29%+mezcla de levaduras, comparado con el crecimiento de la dieta control. La dieta complementada con la mezcla de levaduras mostró el valor más alto de supervivencia y THC de juveniles comparado con los demás tratamientos experimentales. Los diferentes niveles experimentales de CP incluidos en la dieta de camarón incrementaron crecimiento, supervivencia y hemocitos circulantes; la adición de una mezcla de levaduras como aditivo alimentario, indujo mejor supervivencia y respuesta inmune en juveniles de camarón.

[Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is associated with the response to tumor necrosis factor inhibitor (TNFi) therapy. Methods: Peripheral blood genome-wide DNA methylation profiles were analyzed in a discovery cohort of 62 RA patients at baseline and at week 12 of TNFi therapy. DNA methylation of individual CpG sites and enrichment of biological pathways were evaluated for their association with drug response. Using a novel cell deconvolution approach, altered DNA methylation associated with TNFi response was also tested in the six main immune cell types in blood. Validation of the results was performed in an independent longitudinal cohort of 60 RA patients. Findings: Treatment with TNFi was associated with significant longitudinal peripheral blood methylation changes in biological pathways related to RA (FDR<0.05). 139 biological functions were modified by therapy, with methylation levels changing systematically towards a signature similar to that of healthy controls. Differences in the methylation profile of T cell activation and differentiation, GTPase-mediated signaling, and actin filament organization pathways were associated with the clinical response to therapy. Cell type deconvolution analysis identified CpG sites in CD4+T, NK, neutrophils and monocytes that were significantly associated with the response to TNFi. Interpretation: Our results show that treatment with TNFi restores homeostatic blood methylation in RA. The clinical response to TNFi is associated to methylation variation in specific biological pathways, and it involves cells from both the innate and adaptive immune systems.

Anal cancer incidence is higher in persons living with HIV/AIDS (PLWHA) than in the general population. Participation of PLWHA in anal cancer clinical trials (CTs) is essential; Hispanic PLWHA are underrepresented in CTs. We conducted a behavioral CT among 305 PLWHA in Puerto Rico to measure the efficacy of an educational video in increasing calls and screening into an anal cancer CT. Participants received printed educational materials on anal cancer and CTs; the intervention group also received an educational video. Outcome assessment based on follow-up interviews showed that printed materials increased awareness about CTs and high-resolution anoscopy (HRA), and willingness to participate in an anal cancer CT in both groups. However, the addition of the video increased the likelihood of participants to call the CT for orientation (RRadjusted = 1.66, 95% CI 1.00-2.76; p = 0.05) and pre-screening evaluation (RRadjusted = 1.70, 95% CI 0.95-3.03; p = 0.07). This intervention could help increase participation of Hispanics into anal cancer-related CTs.

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.

Background Robust age-specific estimates of anal human papillomavirus (HPV) and high-grade squamous intraepithelial lesions (HSIL) in men can inform anal cancer prevention efforts. We aimed to evaluate the age-specific prevalence of anal HPV, HSIL, and their combination , in men, stratified by HIV status and sexuality. Methods We did a systematic review for studies on anal HPV infection in men and a pooled analysis of individual-level data from eligible studies across four groups: HIV-positive men who have sex with men (MSM), HIV-negative MSM, HIV-positive men who have sex with women (MSW), and HIV-negative MSW. Studies were required to inform on type-specific HPV infection (at least HPV16), detected by use of a PCR-based test from anal swabs, HIV status, sexuality (MSM, including those who have sex with men only or also with women, or MSW), and age. Authors of eligible studies with a sample size of 200 participants or more were invited to share deidentified individual-level data on the above four variables. Authors of studies including 40 or more HIV-positive MSW or 40 or more men from Africa (irrespective of HIV status and sexuality) were also invited to share these data. Pooled estimates of anal high-risk HPV (HR-HPV, including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68), and HSIL or worse (HSIL+), were compared by use of adjusted prevalence ratios (aPRs) from generalised linear models. Findings The systematic review identified 93 eligible studies, of which 6 4 contributed data on 29 900 men to the pooled analysis. Among HIV-negative MSW anal HPV16 prevalence was 1.8% (91 of 5190) and HR-HPV prevalence was 6.9% (345 of 5003); among HIV-positive MSW the prevalences were 8.7% (59 of 682) and 26.9% (179 of 666); among HIV-negative MSM they were 13.7% (1455 of 10 617) and 41.2% (3798 of 9215), and among HIV-positive MSM 28.5% (3819 of 13 411) and 74.3% (8765 of 11 803). In HIV-positive MSM, HPV16 prevalence was 5.6% (two of 36) among those age 15-18 ye

Because of the scarce tourism promotion of Zaruma Canton in relation to its natural and cultural charm, many people are unaware of what hides the "Sultan of El Oro". Zaruma is a magical town that has many attributes that have given it over the years to be a City of National Tourist Interest, Cultural Heritage of Ecuador and Magical Town. That is why this research aims to promote the tourist areas of the Zaruma canton through tools that allow it to improve its competitiveness in the tourism market of the province of El Oro. A non-experimental methodology of a descriptive exploratory nature with a qualitative and quantitative approach was used. The people involved in the study were the community, tourists and tourism professionals. The results show that the lack of management by governmental institutions in relation to promotion and diffusion has caused the resources of the canton to be abandoned. In addition, the community is willing to help these attractions to have a greater scope in relation to promotion, also service providers in the community want to join to be part of the changes made by the municipal government to generate more income in relation to tourism., A causa de la escasa promoción turística del Cantón Zaruma en relación a su encanto natural como cultural, muchas personas desconocen lo que esconde la “Sultana de El Oro”. Zaruma es un pueblo mágico que cuenta con muchos atributos que le han otorgado al pasar de los años por ser una Ciudad de interés Turístico Nacional, Patrimonio cultural de Ecuador y Pueblo Mágico. Es por ello que la presente investigación tiene como objetivo promocionar los espacios turísticos del cantón Zaruma a través de herramientas que le permita mejorar su competitividad en el mercado turístico de la provincia de El Oro. Se ha utilizado una metodología no experimental de carácter exploratoria descriptiva con enfoque cualitativo y cuantitativo. Las personas involucradas para el estudio fueron la comunidad, los turistas y profesionales en la rama del turismo. Los resultados muestran que la falta de gestión por parte de las institucionales gubernamentales en relacion a promoción y difusión ha provocado que los recursos que posee el cantón queden en el abandono. Además, la comunidad esta predispuesta a ayudar para que estos atractivos lleguen a tener un mayor alcance en relacion a promoción, también los prestadores de servicios de la comunidad desean sumarse para formar parte de los cambios que realice el GAD municipal para que se genere mayores ingresos en relacion a la actividad turística.

The article related conflict management and the response capacity of school groups, including teachers and managers. Therefore, its objective is to analyze the teachers’ perception of conflict management within the school group, made up of students, teachers, managers, administrative staff, mothers and fathers. Based on a quantitative methodological approach, a questionnaire on participatory climate was applied, with a sample of 814 teachers of basic primary education, in Mexico, within the state of Chihuahua, selected at random. The responses were processed through a descriptive frequency analysis. There was evidence of recognition of the work of managers and the ability to face problems; In contrast, the initiative and personal disposition of the teaching staff have low scores. On the other hand, collective work, although it presents intermediate scores, is an indicator of cultural change. In conclusion, there is a disparity between the manager’s attributes with respect to those of the teaching staff; participation is considered an important element in decision-making, specifically in the School Technical Group., El artículo aborda el manejo de conflictos y la capacidad de respuesta de los colectivos escolares, incluyendo docentes y directivos. Por tanto, su objetivo es analizar la percepción de los docentes sobre el manejo de conflictos dentro del colectivo escolar, integrado por estudiantes, docentes, directivos, personal administrativo, madres y padres de familia. Fundamentado en un enfoque metodológico cuantitativo se aplicó un cuestionario sobre clima participativo, con una muestra de 814 docentes de educación básica primaria, en México, dentro del estado de Chihuahua, seleccionados de manera aleatoria. Las respuestas se procesaron mediante un análisis descriptivo de frecuencias. Se evidenció la existencia de un reconocimiento al trabajo de los directivos y la capacidad para enfrentar los problemas; en contraste, la iniciativa y disposición personal del profesorado tienen puntajes bajos. Por otra parte, el trabajo colectivo, aunque presenta puntajes intermedios, es un indicador de cambio cultural. En conclusión, existe una disparidad entre los atributos del directivo con respecto a los del personal docente; la participación se considera un elemento importante en la toma de decisiones, específicamente en el Consejo Técnico Escolar.

La contaminación acústica es un problema que interfiere en el desarrollo urbano sostenible y posiblemente en el riesgo de desastres a largo plazo, por lo que, este trabajo abordó las afectaciones socioambientales ocasionadas por fuentes fijas generadoras de ruido y la incidencia en el desarrollo urbano sostenible del barrio La Granja, Municipio de Montería, Colombia. Se consideraron aspectos relacionados con el buen vivir, el cuidado y las ciudades sostenibles. La metodología fue tipo mixto mediante etapas, a través de las cuales se identificaron y analizaron las características de la problemática, considerando comportamientos sociales, vulnerabilidad y aptitudes de la población. Los resultados obtenidos permiten establecer que la población reconoce una relación directa entre las fuentes fijas emisoras de ruido y las afectaciones negativas sobre su buen vivir. Las principales conclusiones indican que los niveles de ruido obtenidos en la caracterización para puntos y horarios determinados no cumplen la Resolución Colombiana 0627 de 2006 para un sector B (Residencial), así los habitantes de la zona reconocen que existe contaminación ambiental, y falencias en los procedimientos de seguimiento y control realizados por las autoridades competentes., Noise pollution is a problem that interferes with sustainable urban development and possibly the risk of disasters in the long term. Therefore, this work addressed the socio-environmental effects caused by fixed sources of noise and the impact on sustainable urban development in the La Granja neighborhood, Municipality of Montería, Colombia. Aspects related to good living, care and sustainable cities were considered. The methodology used a mixed type, varying through stages. In which the characteristics of the problem were identified and analyzed, considering social behaviors, vulnerability and skills of the population. The results obtained allow us to establish that the population recognizes a direct relationship between the fixed sources that emit noise and the negative effects on their good living. The main conclusion indicates that the noise levels obtained in the characterization for certain points and times do not comply with Colombian Resolution 0627 of 2006 for a sector B (Residential). Thus, residents recognize that there is environmental contamination, and shortcomings in the monitoring and control procedures carried out by the authorities.

[Background] Robust age-specific estimates of anal human papillomavirus (HPV) and high-grade squamous intraepithelial lesions (HSIL) in men can inform anal cancer prevention efforts. We aimed to evaluate the age-specific prevalence of anal HPV, HSIL, and their combination, in men, stratified by HIV status and sexuality., [Methods] We did a systematic review for studies on anal HPV infection in men and a pooled analysis of individual-level data from eligible studies across four groups: HIV-positive men who have sex with men (MSM), HIV-negative MSM, HIV-positive men who have sex with women (MSW), and HIV-negative MSW. Studies were required to inform on type-specific HPV infection (at least HPV16), detected by use of a PCR-based test from anal swabs, HIV status, sexuality (MSM, including those who have sex with men only or also with women, or MSW), and age. Authors of eligible studies with a sample size of 200 participants or more were invited to share deidentified individual-level data on the above four variables. Authors of studies including 40 or more HIV-positive MSW or 40 or more men from Africa (irrespective of HIV status and sexuality) were also invited to share these data. Pooled estimates of anal high-risk HPV (HR-HPV, including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68), and HSIL or worse (HSIL+), were compared by use of adjusted prevalence ratios (aPRs) from generalised linear models., [Findings] The systematic review identified 93 eligible studies, of which 64 contributed data on 29 900 men to the pooled analysis. Among HIV-negative MSW anal HPV16 prevalence was 1·8% (91 of 5190) and HR-HPV prevalence was 6·9% (345 of 5003); among HIV-positive MSW the prevalences were 8·7% (59 of 682) and 26·9% (179 of 666); among HIV-negative MSM they were 13·7% (1455 of 10 617) and 41·2% (3798 of 9215), and among HIV-positive MSM 28·5% (3819 of 13 411) and 74·3% (8765 of 11 803). In HIV-positive MSM, HPV16 prevalence was 5·6% (two of 36) among those age 15–18 years and 28·8% (141 of 490) among those age 23–24 years (ptrend=0·0091); prevalence was 31·7% (1057 of 3337) among those age 25–34 years and 22·8% (451 of 1979) among those age 55 and older (ptrend<0·0001). HPV16 prevalence in HIV-negative MSM was 6·7% (15 of 223) among those age 15–18 and 13·9% (166 of 1192) among those age 23–24 years (ptrend=0·0076); the prevalence plateaued thereafter (ptrend=0·72). Similar age-specific patterns were observed for HR-HPV. No significant differences for HPV16 or HR-HPV were found by age for either HIV-positive or HIV-negative MSW. HSIL+ detection ranged from 7·5% (12 of 160) to 54·5% (61 of 112) in HIV-positive MSM; after adjustment for heterogeneity, HIV was a significant predictor of HSIL+ (aPR 1·54, 95% CI 1·36–1·73), HPV16-positive HSIL+ (1·66, 1·36–2·03), and HSIL+ in HPV16-positive MSM (1·19, 1·04–1·37). Among HPV16-positive MSM, HSIL+ prevalence increased with age., [Interpretation] High anal HPV prevalence among young HIV-positive and HIV-negative MSM highlights the benefits of gender-neutral HPV vaccination before sexual activity over catch-up vaccination. HIV-positive MSM are a priority for anal cancer screening research and initiatives targeting HPV16-positive HSIL+.

Natalia Rodriguez,1,&ast; Albert Martinez-Pinteño,1,&ast; Ana Blázquez,2,3 Ana Encarnación Ortiz,2,3 Elena Moreno,2 Patricia Gassó,1,3 Amalia Lafuente,1,3,4 Luisa Lazaro,2– 5 Sergi Mas1,3,4 1Department of Basic Clinical Practice, Pharmacology Unit, University of Barcelona, Barcelona, Spain; 2Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain; 3Clinical and Experimental Neuroscience Area, The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; 4G04 Group, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Madrid, Spain; 5Department of Medicine, University of Barcelona, Barcelona, Spain&ast;These authors contributed equally to this workCorrespondence: Sergi MasDepartment of Basic Clinical Practice, Pharmacology Unit, University of Barcelona, Casanova 143, Barcelona, E-08036, SpainTel +34934024526Fax +34934035881Email sergimash@ub.eduPurpose: Here, we propose an integrative analysis of genome-wide methylation and gene expression to provide new insight into the biological mechanisms of Cognitive behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD).Patients and Methods: Twelve children and adolescents with OCD receiving CBT for the first time were classified as responders or non-responders after eight weeks of CBT. Differentially methylated positions (DMPs) and gene co-expression modules were identified using specific R software packages. Correlations between the DMPs and gene co-expression modules were investigated.Results: Two genes were enriched with significant DMPs (Δβ > ± 0.2, FDR-adjusted p-value < 0.05): PIWIL1 and MIR886. The yellowgreen module of co-expressed genes was associated with CBT response (FDR-adjusted p-value = 0.0003). Significant correlations were observed between the yellowgreen module and the CpGs in PIWIL1 and MIR886 (p < 0.008). Patients

INTRODUCTION:Research on the association between periodontitis and oral human papilloma virus (HPV) infection is inconsistent. The cross-sectional association of severe periodontitis with oral HPV infection was investigated in a sample of Hispanic adults. METHODS:Data from the 2014-2016 San Juan Overweight Adults Longitudinal Study (n = 740) was analyzed. Periodontitis assessment and self-collection of oral HPV samples followed the National Health and Nutrition Examination Survey methodology. Periodontitis was defined using the Centers of Disease Control and Prevention/American Academy of Periodontology definition. HPV typing was performed using polymerase chain reaction. Multivariate logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS:5.7% of participants had oral HPV infection and 20.3% had severe periodontitis. Adults with severe periodontitis had higher odds of oral HPV infection than those with none/mild disease (OR=2.9, 95% CI: 1.0-8.4, p < 0.05) in multivariable analysis. Adults with clinical attachment loss≥ 7 mm and pocket depth PD≥ 6 mm had 2- to 3-fold higher odds of HPV infection. CONCLUSIONS:Severe periodontitis was positively associated to oral HPV infection. Longitudinal evaluation of periodontal inflammation's role in acquisition and persistence of oral HPV infection is needed, as periodontitis screening could identify individuals at increased risk of HPV-related oral malignancies.

In the city of Calceta (Manabí, Ecuador) three poultry farms have been identified for the production of eggs, which do not perform any treatment of the excreta of the laying birds, which leads to the generation of gases and bad odors that affect the population. The present work analyzes the efficiency in the reduction of air pollution when treating poultry excreta with different doses of efficient microorganisms (EMs). The experiment was designed in a unifactorial way with four treatments, based on 5 Kg of poultry excreta. Volumetric doses were added in the following order: 0,5; 1,0; and 1,5 liters of EMs; while, 1 liter of water was added as control. The variation of parameters such as pH, humidity, ammonium and the development of colonies of Bacillus spp., Lactobacillus spp. and yeasts. The biostabilization process was evaluated with two measurements, the first at 10 days and the second at 20 days of application of the EMs. The results show that at 20 days the pH values reached ranges between 8,3 and 7,6; a decrease in ammonium concentrations from 3,14 mg/L to 0,60 mg/L was achieved; in the case of humidity, there was a decrease of approximately 50%, which affected the decrease of the microbial population of yeasts, Bacillus spp., and Lactobacillus spp. in more than 90%. In conclusion, the efficient microorganisms allow the reduction of more than 70% of bad odors represented by ammonia, generated by the accumulation of poultry excreta. Keywords: efficient microorganisms; poultry; wastes; air contamination; aerobiology; pathogens., En la ciudad de Calceta (Manabí, Ecuador) se han identificado tres granjas avícolas destinadas a la producción de huevos, las cuales no realizan tratamiento alguno de las excretas de las aves ponedoras, lo que conlleva la generación de gases y malos olores que afectan a la población. El presente trabajo analiza la eficiencia en la reducción de la contaminación del aire al tratar las excretas avícolas con diferentes dosis de microorganismos eficientes (EMs). Se diseñó el experimento de manera unifactorial con cuatro tratamientos, tomando como base 5 Kg de excretas de avícolas. Se agregaron dosis volumétricas de 0,5; 1,0; y 1,5 litros de EMs; mientras que, se agregó 1 litro de agua como control. Se evaluó la variación de parámetros como el pH, humedad, amonio y el desarrollo de colonias de Bacillus spp., Lactobacillus spp. y levaduras. El proceso de bioestabilización fue evaluado con dos mediciones, la primera a los 10 días y la segunda a los 20 días de aplicación de los EMs. Los resultados demuestran que a los 20 días los valores del pH alcanzaron rangos entre 8,3 y 7,6; disminución de concentraciones de amonio desde 3,14 mg/L hasta 0,60 mg/ L; en el caso de la humedad, existió una disminución de aproximadamente 50%, lo cual afectó en la disminución de la población microbiana de levaduras, Bacillus spp., y Lactobacillus spp. en más de un 90%. Se concluye que los microorganismos eficientes empleados permiten la reducción de más del 70% de malos olores representados por el amoniaco, generados por la acumulación de excretas avícolas. Palabras clave: microorganismos eficientes; aves; desechos; contaminación del aire; aerobiología; patógenos.

A review of the literature about identity is presented, particularly the one about basic education teachers had built in Mexico. The purpose of this article is to take in account related conceptual elements besides locating the perspectives assumed for their study, and to identify the categorical emphases that have been made in the production of scientific articles. In addition, an indispensable element is addressed in any study on identity that has to do with the tensions that are experienced in its construction and dynamic variation in a context of change: we refer to teaching identities crisis. The product of this effort, typified as a bibliographic study, is used as one of the reference instruments to facilitate the structure of a theoretical framework for the realization of empirical research with a qualitative approach that uses the narrative method, which are used to structure warps with collective meaning based on the different accounts of teachers who participated, which will lead to the construction of a doctoral thesis., Se presenta una revisión de la literatura sobre el tema de la identidad, particularmente la que han construido los docentes de educación básica en México. La finalidad del presente artículo es dar cuenta de los elementos conceptuales relacionados además de ubicar las perspectivas asumidas para su estudio, así como identificar los énfasis categoriales que se han utilizado en la producción de artículos de divulgación científica. Además, se aborda un elemento indispensable en todo estudio sobre la identidad que tiene que ver con las tensiones que se viven en su construcción y variación dinámica en un contexto de cambios: nos referimos a la crisis de las identidades docentes. El producto de este esfuerzo tipificado como estudio bibliográfico, se utiliza como uno de los instrumentos referentes para facilitar la estructuración de un marco teórico base para la realización de una investigación empírica con enfoque cualitativo que utiliza el método de las narrativas, con las que se estructuran urdimbres con significado colectivo a partir de lo que cuentan diversos profesores participantes, misma que derivará en la construcción de una tesis doctoral.

[Abstract] Objectives: To explore the remission concept in rheumatoid arthritis (RA) and the implications of the existing definitions when applied to clinical practice among rheumatologists with different profiles. Methods: A qualitative study through focus groups was conducted. Three focus groups were organised from February to March 2016. Each group was composed of rheumatologists with extensive clinical experience with different profiles; experts in basic research (RBR), experts in imaging techniques research (RIR), and experts in clinical research (RCR). The data was collected with audio recording. Verbatim transcriptions of the audio files were made, and a subsequent reflexive thematic analysis assisted by ATLAS.ti (GmbH, Berlin, v. 7) software was performed. Results: From the reflexive thematic analysis, three main themes were generated: (1) remission limitations, (2) instruments or measures to assess remission, and (3) a new definition of remission. Rheumatologists mentioned frequently that the following variables should be considered when developing a new remission definition: inflammatory activity, calprotectin, psychological variables, sex, disease stage, and sociocultural factors. Contrary to what could be expected, all groups acknowledged that their research field could contribute with domains for a gold standard remission instrument, but not in a hierarchical arrangement of importance. The dissonance existing in the entire remission evaluation process was outlined: remission in clinical practice versus remission in clinical trials, remission following the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) Boolean versus Musculoskeletal Ultrasound (US) remission, and remission from the rheumatologist's point of view versus the patient's point of view. Conclusions: Currently, rheumatologists would not accept a domain as more important than others in remission. Our suggestion is, not to generate a universal definition of remi

Heavy metals pollution represents a worldwide concern. This work had the objective to evaluate bioaccumulation of mercury and zinc in gill, hepatic and muscular tissue on fish species in the Carrizal river basin. Fourteen monitoring stations were established. APHA AWWA WEF 3112-B and APHA AWWA WEF 3111-B-C methods were used to determine mercury and zinc. In Oreochromis niloticus, the highest concentration of mercury (0.300?mg/kg in august and 0.276?mg/kg in october) and zinc (0.371?mg/kg in august and 0.347?mg/kg in october) was in branches. For Hoplias microlepis there were more mercury in muscle (1.615?mg/kg in august and 1.456 mg/kg in october) and zinc (1.243?mg/kg in august and 1.069 mg/kg in october). Aequidens rivulatus had the highest levels of mercury in muscle (2.034?mg/kg in august and 1.926?mg/kg in october). With reference to zinc, in August 0.373?mg/kg was found in the gills. In august 2017, there was a greater presence of mercury and zinc in the analyzed species. It can be deduced that the biomagnifications of heavy metals has a direct relationship with the use of agricultural inputs., Contaminação por metais pesados representa uma preocupação mundial. Está investigação tuvo como finalidad avaliando a bioacumulação de mercúrio e zinco em tejido branquial, hepático e muscular em espécies ictícolas de la subcuenca del río Carrizal. Se estabeleceu 14 estaciones de monitoreo. Aplique os métodos APHA AWWA WEF 3112-B e APHA AWWA WEF 3111-B-C, para determinar o mercúrio e o zinco. Em Oreochromis niloticus, a concentração de mercúrio (0.300?mg/kg em agosto e 0.276?mg/kg em octubre) e zinco (0.371?mg/kg em agosto e 0.347?mg/kg em octubre) foi mayor en branquias. Para Hoplias microlepis o músculo fue depósito de mercúrio (1.615?mg/kg em agosto e 1.456 mg/kg em octubre) e de zinco (1.243 mg/kg em agosto e 1.069?mg/kg em octubre). Aequidens rivulatus apresenta os valores mais altos de mercúrio em músculo (2.034?mg/kg em agosto e 1.926 mg/kg em outubro). En agosto se encontraron 0.373?mg/kg de zinco en branquias. Em agosto de 2017, existió mayor presencia de mercurio y zinco en las especies analizadas. Biomagnificação de metais pesados tem relação direta con la utilización de insumos agrícolas., La contaminación por metales pesados representa una preocupación mundial. La presente investigación persiguió evaluar la bioacumulación de mercurio y zinc en los tejidos branquial, hepático y muscular en especies ictícolas de la subcuenca del río Carrizal. Se establecieron 14 estaciones de monitoreo. Para la determinación de mercurio y zinc se aplicaron los métodos APHA AWWA WEF 3112-B y APHA AWWA WEF 3111-B-C, respectivamente. En Oreochromis niloticus, la mayor concentración de mercurio (0.300 mg/kg en agosto y 0.276 mg/kg en octubre) y zinc (0.371 mg/kg en agosto y 0.347 mg/kg en octubre) fue mayor en branquias. Para Hoplias microlepis el músculo fue el depósito de mercurio (1.615 mg/kg en agosto y 1.456 mg/kg en octubre) y de zinc (1.243 mg/kg en agosto y 1.069 mg/kg en octubre). El Aequidens rivulatus presentó los valores más altos de mercurio en músculo (2.034 mg/kg en agosto y 1.926 mg/kg en octubre). En cuanto al zinc, en agosto se encontraron 0.373 mg/kg en branquias. Durante el monitoreo realizado en agosto de 2017 existió mayor presencia de mercurio y zinc en las especies analizadas. Se deduce que la biomagnificación de metales pesados en la zona de estudio tiene relación directa con la utilización de insumos agrícolas.

The health contingency due to COVID-19 has an impact in different social problems that have been intensifi ed, since people are under the same roof for long periods of time and sometimes, they have been unemployed due to the closure of some sources of employment. This document will delve into the consequences of the current pandemic situation caused by COVID-19. Unemployment and violence at home has had a significant increase since the beginning of the quarantine, in addition, traditional gender roles have been reaffirmed, that were apparently overcome until now, among other interesting considerations., La contingencia sanitaria a casusa del COVID-19 impacta en diferentes problemáticas sociales que se han intensificado, pues las familias están por largos periodos de tiempo bajo el mismo techo y en algunas ocasiones, han quedado desempleados a causa del cierre de algunas fuentes de empleo. En el presente documento se profundizará en las consecuencias que ha tenido la situación que se vive con la pandemia provocada por el COVID-19. El desempleo y la violencia en el hogar han tenido un incremento considerable desde el inicio de la cuarentena, además, se han reafirmado los roles tradicionales de género, que se creían hasta hace poco superados, entre otras interesantes consideraciones.

Este documento presenta una caracterización del trabajo colaborativo internacional sobre la aplicación del juego serio en contenidos curriculares de programas en ciencias económicas relacionadas con las finanzas, la contabilidad y la administración. Se tomó como referencia información compilada de la base de datos académica Scopus durante la ventana de observación 2007-2018, teniendo en cuenta indicadores bibliométricos, metodologías destacadas, tendencias de uso o aplicación y desafíos o retos de la implementación. Como resultado, se logra identificar ocho principales categorías de estrategias de enseñanza-aprendizaje en las cuales Aprendizaje adaptativo, Aprendizaje colaborativo y Gamificación se ubican como las tendencias en las que el uso del juego serio se ha consolidado. Storytelling (narrativa de historias), y el Aprendizaje basado en competencias están en proceso de consolidación. Finalmente, Aprendizaje invertido, Massive Open Online Course (MOOC), y Aprendizaje basado en retos son líneas incipientes en las que el uso del juego serio no se ha desarrollado lo suficiente. De igual manera, se logra destacar, a partir del seguimiento de publicaciones científicas, los principales logros, orientaciones y desafíos de la aplicación de estas estrategias en el aula de clase; particularmente, las relacionadas con las finanzas, la administración y la contaduría.

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show moderate/high disease activity, with aggressive joint damage and multiple systemic manifestations. There is thus is a great need to identify prognostic biomarkers for disease risk to improve diagnosis and prognosis, and to inform on the most appropriate therapy. Here we focused on suppressor of cytokine signaling 1 (SOCS1), a physiological negative regulator of cytokines that modulates cell activation. Using four independent cohorts of patients with arthritis, we characterized the correlation between SOCS1 mRNA levels and clinical outcome. We found a significant inverse correlation between SOCS1 mRNA expression and disease activity throughout the follow-up of patients with RA. Lower baseline SOCS1 levels were associated with poorer disease control in response to methotrexate and other conventional synthetic disease-modifying anti-rheumatic drugs in early arthritis, and to rituximab in established (active) RA. Moreover, we identified several single nucleotide polymorphisms in the SOCS1 gene that correlated with SOCS1 mRNA expression, and that might identify those patients with early arthritis that fulfill RA classification criteria. One of them, rs4780355, is in linkage disequilibrium with a microsatellite (TTTTC), mapped 0.9 kb downstream of the SNP, and correlated with reduced SOCS1 expression in vitro. Overall, our data support the association between SOCS1 expression and disease progression, disease severity and response to treatment in RA. These observations underlie the relevance of SOCS1 mRNA levels for stratifying patients prognostically and guiding therapeutic decisions.

Este estudio analiza los efectos de dos soluciones fisiológicas, Ringer lactato e hydroxietil almidón (HES) 130/0.4 en la mucosa del intestino delgado en cerdos bajo anestesia general sometidos a sangrado agudo. Los resultados de este estudio sugieren, que en una situación de hemorragia controlada, HES 130/0.4 puede minimizar el porcentaje de perdida de mucosa en el intestino delgado, en comparación con una solución Ringer Lactato, cuando estas son usadas para reemplazo de volumen. Los datos en este estudio también sugieren que el duodeno puede ser el segmento de intestino delgado más sensible a hipovolemia causada por sangrado severo. La hiperemia en el intestino delgado fue significativamente mayor con HES 130/0.4 comparada con solución Ringer Lactato; esto sugiere que la administración de HES 130/0.4 podría restaurar la perfusión XXIII intestinal con mayor eficiencia y estar asociada con una menor porcentaje de perdida de mucosa. A pesar de las diferencias muy significativas en histopatología para el porcentaje de perdida de mucosa, los métodos inmunohistoquímicos usados para evaluar los eventos apoptóticos en el epitelio del intestino delgado (anticuerpo citocromo C, método TUNEL y ensayos de inmunofluorescencia M30 Cytodeath), no revelaron diferencias significativas en el porcentaje de apoptosis entre grupos.

[ES] El proyecto consiste en la creación de una serie de tazas de café con sus respectivos platos y cucharitas que hacen referencia a una antigua tradición que nace en Nápoles, en concreto en la cafetería Gambrinus, en el año 1860, época de guerras y pobreza y que se convirtió en símbolo de solidaridad y generosidad y que se conserva hasta día de hoy en algunas cafeterías de Italia. Se basa en una recreación de piezas de una vajilla, con las técnicas de cerámica y fundición, con un acabado que refleja la antigüedad y la historia de esta tradición convertida en arte., [EN] The proyect consists on the creation of cups of coffee with its own plates and spoons, referencing an old tradition born in Naples, specifically in the coffee shop Gambrinus, in 1860, during war and poberty, which became a symbol of solidarity and generosity, preserved nowadays in some italian coffe shops. It is based in a recreation of pottery pieces, using foundry and ceramic techniques showing antiquity and this tradition history turned into art.