9 results on '"Oral, Hakan"'
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2. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development
- Author
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Nielsen, Jonas B., Fritsche, Lars G., Zhou, Wei, Teslovich, Tanya M., Holmen, Oddgeir L., Gustafsson, Stefan, Gabrielsen, Maiken E., Schmidt, Ellen M., Beaumont, Robin, Wolford, Brooke N., Lin, Maoxuan, Brummett, Chad M., Preuss, Michael H., Refsgaard, Lena, Bottinger, Erwin P., Graham, Sarah E., Surakka, Ida, Chu, Yunhan, Skogholt, Anne Heidi, Dalen, Havard, Boyle, Alan P., Oral, Hakan, Herron, Todd J., Kitzman, Jacob, Jalife, Jose, Svendsen, Jesper H., Olesen, Morten S., Njolstad, Inger, Lochen, Maja-Lisa, Baras, Aris, Gottesman, Omri, Marcketta, Anthony, O'Dushlaine, Colm, Ritchie, Marylyn D., Wilsgaard, Tom, Loos, Ruth J. F., Frayling, Timothy M., Boehnke, Michael, Ingelsson, Erik, Carey, David J., Dewey, Frederick E., Kang, Hyun M., Abecasis, Goncalo R., Hveem, Kristian, Willer, Cristen J., Nielsen, Jonas B., Fritsche, Lars G., Zhou, Wei, Teslovich, Tanya M., Holmen, Oddgeir L., Gustafsson, Stefan, Gabrielsen, Maiken E., Schmidt, Ellen M., Beaumont, Robin, Wolford, Brooke N., Lin, Maoxuan, Brummett, Chad M., Preuss, Michael H., Refsgaard, Lena, Bottinger, Erwin P., Graham, Sarah E., Surakka, Ida, Chu, Yunhan, Skogholt, Anne Heidi, Dalen, Havard, Boyle, Alan P., Oral, Hakan, Herron, Todd J., Kitzman, Jacob, Jalife, Jose, Svendsen, Jesper H., Olesen, Morten S., Njolstad, Inger, Lochen, Maja-Lisa, Baras, Aris, Gottesman, Omri, Marcketta, Anthony, O'Dushlaine, Colm, Ritchie, Marylyn D., Wilsgaard, Tom, Loos, Ruth J. F., Frayling, Timothy M., Boehnke, Michael, Ingelsson, Erik, Carey, David J., Dewey, Frederick E., Kang, Hyun M., Abecasis, Goncalo R., Hveem, Kristian, and Willer, Cristen J.
- Abstract
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. The pathogenesis of AF remains poorly understood, which contributes to the current lack of highly effective treatments. To understand the genetic variation and biology underlying AF, we undertook a genome-wide association study (GWAS) of 6,337 AF individuals and 61,607 AF-free individuals from Norway, including replication in an additional 30,679 AF individuals and 278,895 AF-free individuals. Through genotyping and dense imputation mapping from whole-genome sequencing, we tested almost nine million genetic variants across the genome and identified seven risk loci, including two novel loci. One novel locus (lead single-nucleotide variant [SNV] rs12614435; p = 6.76 × 10−18) comprised intronic and several highly correlated missense variants situated in the I-, A-, and M-bands of titin, which is the largest protein in humans and responsible for the passive elasticity of heart and skeletal muscle. The other novel locus (lead SNV rs56202902; p = 1.54 × 10−11) covered a large, gene-dense chromosome 1 region that has previously been linked to cardiac conduction. Pathway and functional enrichment analyses suggested that many AF-associated genetic variants act through a mechanism of impaired muscle cell differentiation and tissue formation during fetal heart development.
- Published
- 2018
- Full Text
- View/download PDF
3. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development
- Author
-
Nielsen, Jonas B., Fritsche, Lars G, Zhou, Wei, Teslovich, Tanya M, Holmen, Oddgeir L, Gustafsson, Stefan, Gabrielsen, Maiken E, Schmidt, Ellen M, Beaumont, Robin, Wolford, Brooke N, Lin, Maoxuan, Brummett, Chad M, Preuss, Michael H, Refsgaard, Lena, Bottinger, Erwin P, Graham, Sarah E, Surakka, Ida, Chu, Yunhan, Skogholt, Anne Heidi, Dalen, Håvard, Boyle, Alan P, Oral, Hakan, Herron, Todd J, Kitzman, Jacob, Jalife, José, Svendsen, Jesper H., Olesen, Morten S., Njølstad, Inger, Løchen, Maja-Lisa, Baras, Aris, Gottesman, Omri, Marcketta, Anthony, O'Dushlaine, Colm, Ritchie, Marylyn D, Wilsgaard, Tom, Loos, Ruth J.F., Frayling, Timothy M, Boehnke, Michael, Ingelsson, Erik, Carey, David J, Dewey, Frederick E, Kang, Hyun M, Abecasis, Gonçalo R, Hveem, Kristian, Willer, Cristen J, Nielsen, Jonas B., Fritsche, Lars G, Zhou, Wei, Teslovich, Tanya M, Holmen, Oddgeir L, Gustafsson, Stefan, Gabrielsen, Maiken E, Schmidt, Ellen M, Beaumont, Robin, Wolford, Brooke N, Lin, Maoxuan, Brummett, Chad M, Preuss, Michael H, Refsgaard, Lena, Bottinger, Erwin P, Graham, Sarah E, Surakka, Ida, Chu, Yunhan, Skogholt, Anne Heidi, Dalen, Håvard, Boyle, Alan P, Oral, Hakan, Herron, Todd J, Kitzman, Jacob, Jalife, José, Svendsen, Jesper H., Olesen, Morten S., Njølstad, Inger, Løchen, Maja-Lisa, Baras, Aris, Gottesman, Omri, Marcketta, Anthony, O'Dushlaine, Colm, Ritchie, Marylyn D, Wilsgaard, Tom, Loos, Ruth J.F., Frayling, Timothy M, Boehnke, Michael, Ingelsson, Erik, Carey, David J, Dewey, Frederick E, Kang, Hyun M, Abecasis, Gonçalo R, Hveem, Kristian, and Willer, Cristen J
- Abstract
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. The pathogenesis of AF remains poorly understood, which contributes to the current lack of highly effective treatments. To understand the genetic variation and biology underlying AF, we undertook a genome-wide association study (GWAS) of 6,337 AF individuals and 61,607 AF-free individuals from Norway, including replication in an additional 30,679 AF individuals and 278,895 AF-free individuals. Through genotyping and dense imputation mapping from whole-genome sequencing, we tested almost nine million genetic variants across the genome and identified seven risk loci, including two novel loci. One novel locus (lead single-nucleotide variant [SNV] rs12614435; p = 6.76 × 10-18) comprised intronic and several highly correlated missense variants situated in the I-, A-, and M-bands of titin, which is the largest protein in humans and responsible for the passive elasticity of heart and skeletal muscle. The other novel locus (lead SNV rs56202902; p = 1.54 × 10-11) covered a large, gene-dense chromosome 1 region that has previously been linked to cardiac conduction. Pathway and functional enrichment analyses suggested that many AF-associated genetic variants act through a mechanism of impaired muscle cell differentiation and tissue formation during fetal heart development.
- Published
- 2018
4. European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE)
- Author
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Katritsis, Demosthenes G, Boriani, Giuseppe, Cosio, Francisco G, Hindricks, Gerhard, Jaïs, Pierre, Josephson, Mark E, Keegan, Roberto, Kim, Young-Hoon, Knight, Bradley P, Kuck, Karl-Heinz, Lane, Deirdre A, Lip, Gregory Y H, Malmborg, Helena, Oral, Hakan, Pappone, Carlo, Themistoclakis, Sakis, Wood, Kathryn A, Blomström-Lundqvist, Carina, Gorenek, Bulent, Dagres, Nikolaos, Dan, Gheorge-Andrei, Vos, Marc A, Kudaiberdieva, Gulmira, Crijns, Harry, Roberts-Thomson, Kurt, Lin, Yenn-Jiang, Vanegas, Diego, Caorsi, Walter Reyes, Cronin, Edmond, Rickard, Jack, Katritsis, Demosthenes G, Boriani, Giuseppe, Cosio, Francisco G, Hindricks, Gerhard, Jaïs, Pierre, Josephson, Mark E, Keegan, Roberto, Kim, Young-Hoon, Knight, Bradley P, Kuck, Karl-Heinz, Lane, Deirdre A, Lip, Gregory Y H, Malmborg, Helena, Oral, Hakan, Pappone, Carlo, Themistoclakis, Sakis, Wood, Kathryn A, Blomström-Lundqvist, Carina, Gorenek, Bulent, Dagres, Nikolaos, Dan, Gheorge-Andrei, Vos, Marc A, Kudaiberdieva, Gulmira, Crijns, Harry, Roberts-Thomson, Kurt, Lin, Yenn-Jiang, Vanegas, Diego, Caorsi, Walter Reyes, Cronin, Edmond, and Rickard, Jack
- Published
- 2017
- Full Text
- View/download PDF
5. Occult atrial fibrillation in endurance athletes
- Author
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Aggarwal,Ashim, Heslop,Jeffrey, Wigant,Rebecca, Venkatapuram,Suneetha, Hillis,Stephanie, Parr,Alan, Oral,Hakan, Baman,Timir, Aggarwal,Ashim, Heslop,Jeffrey, Wigant,Rebecca, Venkatapuram,Suneetha, Hillis,Stephanie, Parr,Alan, Oral,Hakan, and Baman,Timir
- Abstract
Ashim Aggarwal,1 Jeffrey J Heslop,1 Rebecca R Wigant,1 Suneetha Venkatapuram,1 Stephanie J Hillis,1 Alan R Parr,1 Hakan Oral,2 Timir S Baman11Cardiology Department, University of Illinois College of Medicine at Peoria and OSF Saint Francis Medical Center, Peoria, IL, USA; 2Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, MI, USAAlthough low-to-moderate intensity exercise has been shown to result in decreased cardiovascular morbidity and mortality, limited data suggest that there may be an association between atrial fibrillation (AF) and trained endurance athletes.1 The aim of our study was to prospectively evaluate moderately trained athletes for the occurrence of occult AF.
- Published
- 2017
6. Executive Summary : European Heart Rhythm Association Consensus Document on the Management of Supraventricular Arrhythmias
- Author
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Katritsis, Demosthenes G, Boriani, Giuseppe, Cosio, Francisco G, Jais, Pierre, Hindricks, Gerhard, Josephson, Mark E, Keegan, Roberto, Knight, Bradley P, Kuck, Karl-Heinz, Lane, Deirdre A, Lip, Gregory Yh, Malmborg, Helena, Oral, Hakan, Pappone, Carlo, Themistoclakis, Sakis, Wood, Kathryn A, Young-Hoon, Kim, Blomström-Lundqvist, Carina, Katritsis, Demosthenes G, Boriani, Giuseppe, Cosio, Francisco G, Jais, Pierre, Hindricks, Gerhard, Josephson, Mark E, Keegan, Roberto, Knight, Bradley P, Kuck, Karl-Heinz, Lane, Deirdre A, Lip, Gregory Yh, Malmborg, Helena, Oral, Hakan, Pappone, Carlo, Themistoclakis, Sakis, Wood, Kathryn A, Young-Hoon, Kim, and Blomström-Lundqvist, Carina
- Abstract
This paper is an executive summary of the full European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, published in Europace. It summarises developments in the field and provides recommendations for patient management, with particular emphasis on new advances since the previous European Society of Cardiology guidelines. The EHRA consensus document is available to read in full at http://europace.oxfordjournals.org.
- Published
- 2016
- Full Text
- View/download PDF
7. Mechanism of Ventricular Tachycardia Termination by Pacing at Left Ventricular Sites in Patients with Coronary Artery Disease
- Author
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Division of Cardiology, University of Michigan Medical Center, Ann Arbor, MI, Division of Cardiology, J.W. Goethe University, Frankfurt, Germany, Ann Arbor, Bogun, Frank, Hohnloser, Stefan H., Bender, Birgit, Li, Yi-Gang, Groenefeld, Gerian, Pelosi, Frank, Oral, Hakan, Knight, Bradley P., Strickberger, S. Adam, Morady, Fred, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, MI, Division of Cardiology, J.W. Goethe University, Frankfurt, Germany, Ann Arbor, Bogun, Frank, Hohnloser, Stefan H., Bender, Birgit, Li, Yi-Gang, Groenefeld, Gerian, Pelosi, Frank, Oral, Hakan, Knight, Bradley P., Strickberger, S. Adam, and Morady, Fred
- Abstract
Objective: The mechanism by which pacing terminates ventricular tachycardia (VT) may depend on the location of the pacing site relative to the reentry circuit. The purpose of this study was to compare the mechanisms by which pacing terminates VT at left ventricular (LV) sites with and without concealed entrainment (CE) in patients with prior myocardial infarction.
- Published
- 2006
8. Relative Timing of Isolated Potentials During Postinfarction Ventricular Tachycardia and Sinus Rhythm
- Author
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University of Michigan Medical Center, Ann Arbor, MI, USA, Henry Ford Hospital, Detroit, Michigan, USA, Division of Cardiology, J.W. Goethe University, Frankfurt, Germany, Ann Arbor, Bogun, Frank, Marine, Joseph E., Hohnloser, Stefan H., Oral, Hakan, Pelosi, Frank, Morady, Fred, University of Michigan Medical Center, Ann Arbor, MI, USA, Henry Ford Hospital, Detroit, Michigan, USA, Division of Cardiology, J.W. Goethe University, Frankfurt, Germany, Ann Arbor, Bogun, Frank, Marine, Joseph E., Hohnloser, Stefan H., Oral, Hakan, Pelosi, Frank, and Morady, Fred
- Abstract
Background: In postinfarction patients, isolated potentials separated by an isoelectric segment from the ventricular electrogram indicate areas of block. Isolated potentials can be recorded during both sinus rhythm and ventricular tachycardia (VT). In an attempt to differentiate bystander pathways from critical sites within a reentry circuit, we compared the relative timing of isolated potentials during VT and sinus rhythm.
- Published
- 2006
9. Conducting Randomized Trials in the Electrophysiology Laboratory: Lessons from a Randomized Comparison of Recording Methods During Pulmonary Vein Isolation by Segmental Ostial Ablation
- Author
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Division of Cardiology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, Oral, Hakan, Morady, Fred, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, Oral, Hakan, and Morady, Fred
- Abstract
Accurate identification of pulmonary vein (PV) potentials during segmental ostial ablation for PV isolation is very important to completely isolate the PVs and also to avoid unnecessary applications of radiofrequency energy. A prior post hoc analysis of unipolar and bipolar electrograms recorded from successful and unsuccessful ablation sites demonstrated that unipolar electrograms recorded at successful sites were more likely to have a rapid intrinsic deflection, larger amplitude, and earlier activation than electrograms recorded at unsuccessful sites. Moreover, unipolar electrograms recorded from the ablation and circular ostial mapping catheters were almost identical at successful sites. Based on these observations, a prospective, randomized study was conducted to test whether unipolar and bipolar electrograms would facilitate the ablation procedure when compared to bipolar electrograms alone during PV isolation in patients with atrial fibrillation (AF). In 44 consecutive patients with paroxysmal AF, 114 PVs were randomized to segmental ostial ablation guided by unipolar and bipolar electrograms (61) or by bipolar electrograms only (53). Segmental ostial ablation guided by unipolar and bipolar electrograms was associated with a??? 20???30% decrease in the procedure and fluoroscopy times necessary for isolation of a PV and also in the duration of radiofrequency energy application required for complete isolation of a PV. Although the sample size was not sufficient to detect a 5% change, the success rate for complete electrical isolation and the risk of symptomatic PV stenosis were similar between the 2 groups. Online analysis of unipolar electrograms facilitated the PV isolation procedure and was incremental to the analysis of bipolar electrograms alone. However, because segmental ostial ablation has only modest efficacy in achieving long-term freedom from recurrent AF, alternative ablation strategies that may or may not target PVs will eventually evolve. The role
- Published
- 2006
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