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Background: Positron emission tomography (PET) is a valuable tool for the characterization of brain tumors in vivo. However, few studies have investigated the correlation between carbon-11-methionine (11C-METH) PET metrics and the clinical, radiological, histological, and molecular features of patients affected by lower grade gliomas (LGGs). The present observational study evaluated the relationships between 11C-METH PET metrics and structural magnetic resonance imaging (MRI) findings with the histomolecular biomarkers in patients with LGGs who were candidates for surgery. Methods: We enrolled 96 patients with pathologically proven LGG (51 men, 45 women; age 44.1 ± 13.7 years; 45 with grade II, 51 with grade III), who had been referred from March 2012 to January 2015 for tumor resection and had undergone preoperative 11C-METH PET. The semiquantitative metrics for 11C-METH PET included maximum standardized uptake value (SUVmax), SUV ratio to normal brain, and metabolic tumor burden (MTB). The PET semiquantitative metrics were analyzed and compared with the MRI features, histological diagnosis, isocitrate dehydrogenase-1/2 status, and 1p/19q codeletion. Results: Histological grade was associated with SUVmax (P = 0.002), SUV ratio (P = 0.011), and MTB (P = 0.001), with grade III lesions showing higher values. Among the nonenhancing lesions on MRI, SUVmax (P = 0.001), SUV ratio (P = 0.003) and MTB (P < 0.001) were significantly different statistically for grade II versus grade III. The MRI lesion volume correlated poorly with MTB (r2 = 0.13). The SUVmax and SUV ratio were greater (P < 0.05) in isocitrate dehydrogenase-1/2 wild-type lesions, and the SUV ratio was associated with the presence of the 1p19q codeletion. Conclusions: The 11C-METH PET metrics correlated significantly with histological grade and the molecular profile. Semiquantitative PET metrics can improve the preoperative evaluation of LGGs and thus support clinical decision-making.

HI intensity mapping is a new observational technique to survey the large-scale structure of matter using the 21 cm emission line of atomic hydrogen (HI). In this work, we simulate BINGO (BAO from Integrated Neutral Gas Observations) and SKA (Square Kilometre Array) phase-1 dish array operating in auto-correlation mode. For the optimal case of BINGO with no foregrounds, the combination of the HI angular power spectra with Planck results allows $w$ to be measured with a precision of $4\%$, while the combination of the BAO acoustic scale with Planck gives a precision of $7\%$. We consider a number of potentially complicating effects, including foregrounds and redshift dependent bias, which increase the uncertainty on $w$ but not dramatically; in all cases the final uncertainty is found to be $\Delta w < 8\%$ for BINGO. For the combination of SKA-MID in auto-correlation mode with Planck, we find that, in ideal conditions, $w$ can be measured with a precision of $4\%$ for the redshift range $0.35 < z < 3$ (i.e., for the bandwidth of $\Delta \nu = [350, 1050]$ MHz) and $2\%$ for $0 < z < 0.49$ (i.e., $\Delta \nu = [950, 1421]$ MHz). Extending the model to include the sum of neutrino masses yields a $95\%$ upper limit of $\sum m_\nu < 0.24$ eV for BINGO and $\sum m_\nu < 0.08$ eV for SKA phase 1, competitive with the current best constraints in the case of BINGO and significantly better than them in the case of SKA., Comment: 18 pages, 7 figures, 6 tables. Updated to match version accepted by MNRAS

HI intensity mapping is a new observational technique to survey the large-scale structure of matter using the 21 cm emission line of atomic hydrogen (HI). In this work, we simulate BINGO (BAO from Integrated Neutral Gas Observations) and SKA (Square Kilometre Array) phase-1 dish array operating in auto-correlation mode. For the optimal case of BINGO with no foregrounds, the combination of the HI angular power spectra with Planck results allows $w$ to be measured with a precision of $4\%$, while the combination of the BAO acoustic scale with Planck gives a precision of $7\%$. We consider a number of potentially complicating effects, including foregrounds and redshift dependent bias, which increase the uncertainty on $w$ but not dramatically; in all cases the final uncertainty is found to be $\Delta w < 8\%$ for BINGO. For the combination of SKA-MID in auto-correlation mode with Planck, we find that, in ideal conditions, $w$ can be measured with a precision of $4\%$ for the redshift range $0.35 < z < 3$ (i.e., for the bandwidth of $\Delta \nu = [350, 1050]$ MHz) and $2\%$ for $0 < z < 0.49$ (i.e., $\Delta \nu = [950, 1421]$ MHz). Extending the model to include the sum of neutrino masses yields a $95\%$ upper limit of $\sum m_\nu < 0.24$ eV for BINGO and $\sum m_\nu < 0.08$ eV for SKA phase 1, competitive with the current best constraints in the case of BINGO and significantly better than them in the case of SKA., Comment: 18 pages, 7 figures, 6 tables. Updated to match version accepted by MNRAS

HI intensity mapping is a new observational technique to map fluctuations in the large-scale structure of matter using the 21 cm emission line of atomic hydrogen (HI). Sensitive radio surveys have the potential to detect Baryon Acoustic Oscillations (BAO) at low redshifts (z < 1) in order to constrain the properties of dark energy. Observations of the HI signal will be contaminated by instrumental noise and, more significantly, by astrophysical foregrounds, such as Galactic synchrotron emission, which is at least four orders of magnitude brighter than the HI signal. Foreground cleaning is recognised as one of the key challenges for future radio astronomy surveys. We study the ability of the Generalized Needlet Internal Linear Combination (GNILC) method to subtract radio foregrounds and to recover the cosmological HI signal for a general HI intensity mapping experiment. The GNILC method is a new technique that uses both frequency and spatial information to separate the components of the observed data. Our results show that the method is robust to the complexity of the foregrounds. For simulated radio observations including HI emission, Galactic synchrotron, Galactic free-free, radio sources and 0.05 mK thermal noise, we find that we can reconstruct the HI power spectrum for multipoles 30 < l < 150 with 6% accuracy on 50% of the sky for a redshift z ~ 0.25., Comment: 20 pages, 13 figures. Updated to match version accepted by MNRAS

HI intensity mapping is a new observational technique to map fluctuations in the large-scale structure of matter using the 21 cm emission line of atomic hydrogen (HI). Sensitive radio surveys have the potential to detect Baryon Acoustic Oscillations (BAO) at low redshifts (z < 1) in order to constrain the properties of dark energy. Observations of the HI signal will be contaminated by instrumental noise and, more significantly, by astrophysical foregrounds, such as Galactic synchrotron emission, which is at least four orders of magnitude brighter than the HI signal. Foreground cleaning is recognised as one of the key challenges for future radio astronomy surveys. We study the ability of the Generalized Needlet Internal Linear Combination (GNILC) method to subtract radio foregrounds and to recover the cosmological HI signal for a general HI intensity mapping experiment. The GNILC method is a new technique that uses both frequency and spatial information to separate the components of the observed data. Our results show that the method is robust to the complexity of the foregrounds. For simulated radio observations including HI emission, Galactic synchrotron, Galactic free-free, radio sources and 0.05 mK thermal noise, we find that we can reconstruct the HI power spectrum for multipoles 30 < l < 150 with 6% accuracy on 50% of the sky for a redshift z ~ 0.25., Comment: 20 pages, 13 figures. Updated to match version accepted by MNRAS

Quando comunemente si parla di economia sociale di mercato ci si riferisce alla elaborazione che gli intellettuali della scuola di Friburgo, gli ordoliberali tedeschi, hanno posto in essere soprattutto tra gli anni ‘30 e ‘60 del XX secolo. Nell'opera di questi numerosi studiosi sono individuabili alcuni punti di riferimento che restano fermi e altri che si possono declinare in modo differente nei contesti storici istituzionali specifici.