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1. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

Author

Ono, R., Kumagai, H., Nakajima, H., Hishiya, A., Taki, T., Horikawa, Keisuke, Takatsu, Kiyoshi, Satoh, T., Hayashi, Y., Kitamura, T., Nosaka, T., Ono, R., Kumagai, H., Nakajima, H., Hishiya, A., Taki, T., Horikawa, Keisuke, Takatsu, Kiyoshi, Satoh, T., Hayashi, Y., Kitamura, T., and Nosaka, T.

Abstract

Mixed-lineage-leukemia (MLL) fusion oncogenes are closely involved in infant acute leukemia, which is frequently accompanied by mutations or overexpression of FMS-like receptor tyrosine kinase 3 (FLT3). Earlier studies have shown that MLL fusion proteins

Published
2009

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