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Start Over Author "Nicolotti N." Publication Type Electronic Resources
48 results on '"Nicolotti N."'

1. Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

Author

Mancini, A., Silvestrini, Andrea, Marcheggiani, F., Capobianco, E., Silvestri, S., Lembo, Erminia, Orlando, P., Beccia, Flavia, Nicolotti, Nicola, Panocchia, Nicola, Tiano, L., Silvestrini A. (ORCID:0000-0002-2005-3746), Lembo E., Beccia F., Nicolotti N., Panocchia N., Mancini, A., Silvestrini, Andrea, Marcheggiani, F., Capobianco, E., Silvestri, S., Lembo, Erminia, Orlando, P., Beccia, Flavia, Nicolotti, Nicola, Panocchia, Nicola, Tiano, L., Silvestrini A. (ORCID:0000-0002-2005-3746), Lembo E., Beccia F., Nicolotti N., and Panocchia N.

Abstract

Oxidative stress (OS) is implicated in several chronic diseases. Extra-cellular superoxide dismutase (ec-SOD) catalyses the dismutation of superoxide anions with a protective role in endothelial cells. In chronic kidney disease (CKD), OS and thyroid dysfunction (low fT3 syndrome) are frequently present, but their relationship has not yet been investigated. This cohort study evaluated ec-SOD activity in CKD patients during haemodialysis, divided into "acute haemodialytic patients" (AH, 1-3 months of treatment) and "chronic haemodialytic patients" (CH, treated for a longer period). We also evaluated plasmatic total antioxidant capacity (TAC) and its relationships with thyroid hormones. Two basal samples ("basal 1", obtained 3 days after the last dialysis; and "basal 2", obtained 2 days after the last dialysis) were collected. On the same day of basal 2, a sample was collected 5 and 10 min after the standard heparin dose and at the end of the procedure. The ec-SOD values were significantly higher in CH vs. AH in all determinations. Moreover, the same patients had lower TAC values. When the CH patients were divided into two subgroups according to fT3 levels (normal or low), we found significantly lower ec-SOD values in the group with low fT3 in the basal, 5, and 10 min samples. A significant correlation was also observed between fT3 and ec-SOD in the basal 1 samples. These data, confirming OS and low fT3 syndrome in patients with CKD, suggest that low fT3 concentrations can influence ec-SOD activity and could therefore potentially contribute to endothelial oxidative damage in these patients.

Published
2024

2. Hospital reengineering against COVID-19 outbreak: 1-month experience of an Italian tertiary care center

Author

Tosoni, A., Rizzatti, G., Nicolotti, N., Di Giambenedetto, S., Addolorato, G., Franceschi, F., Dal Verme, L. Z., Tosoni A., Rizzatti G. (ORCID:0000-0003-1876-7587), Nicolotti N., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Tosoni, A., Rizzatti, G., Nicolotti, N., Di Giambenedetto, S., Addolorato, G., Franceschi, F., Dal Verme, L. Z., Tosoni A., Rizzatti G. (ORCID:0000-0003-1876-7587), Nicolotti N., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Addolorato G. (ORCID:0000-0002-1522-9946), and Franceschi F. (ORCID:0000-0001-6266-445X)

Abstract

Objective: The recent outbreak of SARS-CoV-2 infection in Italy has resulted in a sudden and massive flow of patients into emergency rooms, and a high number of hospitalizations with the need for respiratory isolation. Massive admission of patients to the Policlinico "Agostino Gemelli" Foundation of Rome, Italy, determined the need for reengineering the entire hospital. Materials and Methods: In this article, we consider some of the structural and organizational changes that have been necessary to deal with the emergency, with particular reference to non-intensive medicine wards, and the preventive measures aimed at limiting the spread of SARS-CoV-2 infection among hospital staff and patients themselves. Results: 577 staff members were subjected to molecular tests in 1-month period and 3.8% of the total were positive. 636 patients admitted to the COVID-19 pathway were included and analyzed: 45.4% were identified as SARS-CoV-2 positive. More SARS-CoV-2 negative patients were discharged in comparison to SARS-CoV-2 positive patients (59% vs. 41%, respectively). On the other hand, more SARS-CoV-2 positive patients were transferred to ICUs in comparison to SARSCoV-2 negative patients (16% vs. 1%, respectively). Occurrence of death was similar between the two groups, 11% vs. 7%, for SARS-CoV-2 negative and positive patients, respectively. 25% of .80 years old SARS-CoV-2 positive patients died during the hospitalization, while death rate was lower in other age groups (5% in 70-79 years old patients and 0% in remaining age groups). Conclusions: Rapid hospital reengineering has probably had an impact on the management of patients with and without SARS-CoV-2 infection, and on in-hospital mortality rates over the reporting period.

Published
2020

3. EASE SCORE, NOVEL ALGORITHM BASED ON KINETICS OF AST, BILIRUBIN, PLATELETS AND RECIPIENT DATA TO PREDICT EARLY ALLOGRAFT FAILURE. AN ITALIAN MULTICENTER STUDY DESIGNED IN THE PERSPECTIVE OF LIVER RE-TRANSPLANTATION WITH UK VALIDATION

Author

Franco, A, De Simone, P, Schlegel, A, Lai, Q, Burra, P, Patrono, D, Meli, S, Ravaioli, M, Bassi, D, Ferla, F, Pagano, D, Violi, P, Camagni, S, Dondossola, D, Montalti, R, Alrawashdeh, W, Vitale, A, Teofili, L, Ghinolfi, D, Spoletini, G, Maroni, L, Nicolotti, N, Magistri, P, Pastena, D, Bongini, M, Rossi, M, Mazzaferro, V, Di Benedetto, F, Hammond, J, Vivarelli, M, Agnes, S, Colledan, M, Carraro, A, De Carlis, L, Cescon, M, Caccamo, L, Gruttadauria, S, Muiesan, P, Cillo, U, Romagnoli, R, Avolio, A, Franco A, De Simone P, Schlegel A, Lai Q, Burra P, Patrono D, Meli S, Ravaioli M, Bassi D, Ferla F, Pagano D, Violi P, Camagni S, Dondossola D, Montalti R, Alrawashdeh W, Vitale A, Teofili L, Ghinolfi D, Spoletini G, Maroni L, Nicolotti N, Magistri P, Pastena D, Bongini M, Rossi M, Mazzaferro V, Di Benedetto F, Hammond J, Vivarelli M, Agnes S, Colledan M, Carraro A, De Carlis L, Cescon M, Caccamo L, Gruttadauria S, Muiesan P, Cillo U, Romagnoli R, Avolio A, Franco, A, De Simone, P, Schlegel, A, Lai, Q, Burra, P, Patrono, D, Meli, S, Ravaioli, M, Bassi, D, Ferla, F, Pagano, D, Violi, P, Camagni, S, Dondossola, D, Montalti, R, Alrawashdeh, W, Vitale, A, Teofili, L, Ghinolfi, D, Spoletini, G, Maroni, L, Nicolotti, N, Magistri, P, Pastena, D, Bongini, M, Rossi, M, Mazzaferro, V, Di Benedetto, F, Hammond, J, Vivarelli, M, Agnes, S, Colledan, M, Carraro, A, De Carlis, L, Cescon, M, Caccamo, L, Gruttadauria, S, Muiesan, P, Cillo, U, Romagnoli, R, Avolio, A, Franco A, De Simone P, Schlegel A, Lai Q, Burra P, Patrono D, Meli S, Ravaioli M, Bassi D, Ferla F, Pagano D, Violi P, Camagni S, Dondossola D, Montalti R, Alrawashdeh W, Vitale A, Teofili L, Ghinolfi D, Spoletini G, Maroni L, Nicolotti N, Magistri P, Pastena D, Bongini M, Rossi M, Mazzaferro V, Di Benedetto F, Hammond J, Vivarelli M, Agnes S, Colledan M, Carraro A, De Carlis L, Cescon M, Caccamo L, Gruttadauria S, Muiesan P, Cillo U, Romagnoli R, and Avolio A

Published
2019

4. Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis

Author

Avolio, A. W., Gaspari, R., Teofili, L., Bianco, G., Spinazzola, G., Soave, P. M., Paiano, G., Francesconi, A. G., Arcangeli, A., Nicolotti, N., Antonelli, M., Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli A. (ORCID:0000-0001-6755-5981), Nicolotti N., Antonelli M. (ORCID:0000-0003-3007-1670), Avolio, A. W., Gaspari, R., Teofili, L., Bianco, G., Spinazzola, G., Soave, P. M., Paiano, G., Francesconi, A. G., Arcangeli, A., Nicolotti, N., Antonelli, M., Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli A. (ORCID:0000-0001-6755-5981), Nicolotti N., and Antonelli M. (ORCID:0000-0003-3007-1670)

Abstract

Background :Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Methods: Two classification approaches were used: systematic classification (recipient-related preoperative factors; intraoperative factors; logistic factors; donor factors; postoperative ICU factors; postoperative surgical factors) and patient/organ classification (patient-related general factors; native-liver factors; new-liver factors; kidney factors; heart factors; brain factors; lung factors). Two hundred adult non-acute patients were included. Missing analysis was performed. The competitive role of each factor was assessed. Results: PRF occurred in 36.0% of cases. Among 28 significant PRF predictors at univariate analysis, 6 were excluded because of collinearity, 22 were investigated by ROC curves and by logistic regression analysis. Recipient age (OR = 1.05; p = 0.010), female sex (OR = 2.75; p = 0.018), Model for End-Stage Liver Disease (MELD, OR = 1.09; p<0.001), restrictive lung pattern (OR = 2.49; p = 0.027), intraoperative veno-venous bypass (VVBP, OR = 3.03; p = 0.008), pre-extubation PaCO 2 (OR = 1.11; p = 0.003) and Model for Early Allograft Function (MEAF, OR = 1.37; p<0.001) resulted independent PRF risk factors. As compared to patients without PRF, the PRF-group had longer LoS (10 days IQR 7-18 versus 5 days IQR 4-7, respectively; p<0.001) and lower day-90 survival (86.0% versus 97.6% respectively, p<0.001). Conclusion: In conclusion, MELD, restrictive lung pattern, surgical complexity as captured by VVBP, pre-extubation PaCO 2 and MEAF are the main predictors of PRF in non-acute LTx

Published
2019

5. Gemelli decision tree Algorithm to Predict the need for home monitoring or hospitalization of confirmed and unconfirmed COVID-19 patients (GAP-Covid19): preliminary results from a retrospective cohort study

Author

Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, F, Foti, F, D'Ambrosio, F, Cicconi, M, La Milia, Daniele Ignazio, Di Pumpo, M, Carini, E, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De-Giorgio, F, Oliva, A, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R, Murri, Rita, Sabatelli, G, Musolino, M, Gasbarrini, Antonio, Vetrugno, G (ORCID:0000-0003-0181-2855), Laurenti, P (ORCID:0000-0002-8532-0593), LA Milia, D I, Pascucci, D (ORCID:0000-0002-5804-2284), Boccia, S (ORCID:0000-0002-1864-749X), Pastorino, R (ORCID:0000-0001-5013-0733), Damiani, G (ORCID:0000-0003-3028-6188), Nicolotti, N, Cambieri, A, Murri, R (ORCID:0000-0003-4263-7854), Gasbarrini, A (ORCID:0000-0002-7278-4823), Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, F, Foti, F, D'Ambrosio, F, Cicconi, M, La Milia, Daniele Ignazio, Di Pumpo, M, Carini, E, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De-Giorgio, F, Oliva, A, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R, Murri, Rita, Sabatelli, G, Musolino, M, Gasbarrini, Antonio, Vetrugno, G (ORCID:0000-0003-0181-2855), Laurenti, P (ORCID:0000-0002-8532-0593), LA Milia, D I, Pascucci, D (ORCID:0000-0002-5804-2284), Boccia, S (ORCID:0000-0002-1864-749X), Pastorino, R (ORCID:0000-0001-5013-0733), Damiani, G (ORCID:0000-0003-3028-6188), Nicolotti, N, Cambieri, A, Murri, R (ORCID:0000-0003-4263-7854), and Gasbarrini, A (ORCID:0000-0002-7278-4823)

Abstract

OBJECTIVE: To develop a deep learning-based decision tree for the primary care setting, to stratify adult patients with confirmed and unconfirmed coronavirus disease 2019 (COVID-19), and to predict the need for hospitalization or home monitoring.PATIENTS AND METHODS: We performed a retrospective cohort study on data from patients admitted to a COVID hospital in Rome, Italy, between 5 March 2020 and 5 June 2020. A confirmed case was defined as a patient with a positive nasopharyngeal RT-PCR test result, while an unconfirmed case had negative results on repeated swabs. Patients' medical history and clinical, laboratory and radiological findings were collected, and the dataset was used to train a predictive model for COVID-19 severity.RESULTS: Data of 198 patients were included in the study. Twenty-eight (14.14%) had mild disease, 62 (31.31%) had moderate disease, 64 (32.32%) had severe disease, and 44 (22.22%) had critical disease. The G(2) value assessed the contribution of each collected value to decision tree building. On this basis, SpO2 (%) with a cut point at 92 was chosen for the optimal first split. Therefore, the decision tree was built using values maximizing G(2) and LogWorth. After the tree was built, the correspondence between inputs and outcomes was validated.CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized.

Published
2021

6. Gemelli decision tree Algorithm to Predict the need for home monitoring or hospitalization of confirmed and unconfirmed COVID-19 patients (GAP-Covid19): preliminary results from a retrospective cohort study

Author

Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, Francesco, Foti, Francesco, D'Ambrosio, Floriana, Cicconi, M, La Milia, Daniele Ignazio, Di Pumpo, Marcello, Carini, E, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De-Giorgio, F, Oliva, Antonio, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R, Murri, Rita, Sabatelli, G, Musolino, M, Gasbarrini, Antonio, Montini, Luca, Miele, Luca, Gemelli-Against-Covid, Group, Vetrugno, G (ORCID:0000-0003-0181-2855), Laurenti, P (ORCID:0000-0002-8532-0593), Franceschi, F (ORCID:0000-0001-6266-445X), Foti, F, D'Ambrosio, F, LA Milia, D I, Di Pumpo, M, Pascucci, D (ORCID:0000-0002-5804-2284), Boccia, S (ORCID:0000-0002-1864-749X), Pastorino, R (ORCID:0000-0001-5013-0733), Damiani, G (ORCID:0000-0003-3028-6188), Oliva, A (ORCID:0000-0001-7120-616X), Nicolotti, N, Cambieri, A, Murri, R (ORCID:0000-0003-4263-7854), Gasbarrini, A (ORCID:0000-0002-7278-4823), Montini, L (ORCID:0000-0003-4602-5134), Miele, L (ORCID:0000-0003-3464-0068), Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, Francesco, Foti, Francesco, D'Ambrosio, Floriana, Cicconi, M, La Milia, Daniele Ignazio, Di Pumpo, Marcello, Carini, E, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De-Giorgio, F, Oliva, Antonio, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R, Murri, Rita, Sabatelli, G, Musolino, M, Gasbarrini, Antonio, Montini, Luca, Miele, Luca, Gemelli-Against-Covid, Group, Vetrugno, G (ORCID:0000-0003-0181-2855), Laurenti, P (ORCID:0000-0002-8532-0593), Franceschi, F (ORCID:0000-0001-6266-445X), Foti, F, D'Ambrosio, F, LA Milia, D I, Di Pumpo, M, Pascucci, D (ORCID:0000-0002-5804-2284), Boccia, S (ORCID:0000-0002-1864-749X), Pastorino, R (ORCID:0000-0001-5013-0733), Damiani, G (ORCID:0000-0003-3028-6188), Oliva, A (ORCID:0000-0001-7120-616X), Nicolotti, N, Cambieri, A, Murri, R (ORCID:0000-0003-4263-7854), Gasbarrini, A (ORCID:0000-0002-7278-4823), Montini, L (ORCID:0000-0003-4602-5134), and Miele, L (ORCID:0000-0003-3464-0068)

Abstract

OBJECTIVE: To develop a deep learning-based decision tree for the primary care setting, to stratify adult patients with confirmed and unconfirmed coronavirus disease 2019 (COVID-19), and to predict the need for hospitalization or home monitoring.PATIENTS AND METHODS: We performed a retrospective cohort study on data from patients admitted to a COVID hospital in Rome, Italy, between 5 March 2020 and 5 June 2020. A confirmed case was defined as a patient with a positive nasopharyngeal RT-PCR test result, while an unconfirmed case had negative results on repeated swabs. Patients' medical history and clinical, laboratory and radiological findings were collected, and the dataset was used to train a predictive model for COVID-19 severity.RESULTS: Data of 198 patients were included in the study. Twenty-eight (14.14%) had mild disease, 62 (31.31%) had moderate disease, 64 (32.32%) had severe disease, and 44 (22.22%) had critical disease. The G(2) value assessed the contribution of each collected value to decision tree building. On this basis, SpO2 (%) with a cut point at 92 was chosen for the optimal first split. Therefore, the decision tree was built using values maximizing G(2) and LogWorth. After the tree was built, the correspondence between inputs and outcomes was validated.CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized.

Published
2021

7. Gemelli decision tree Algorithm to Predict the need for home monitoring or hospitalization of confirmed and unconfirmed COVID-19 patients (GAP-Covid19): Preliminary results from a retrospective cohort study

Author

Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, Francesco, Foti, F., D'Ambrosio, Floriana, Cicconi, M., La Milia, Daniele Ignazio, Di Pumpo, Marcello, Carini, Elettra, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De Giorgio, Fabio, Oliva, Antonio, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R., Murri, Rita, Sabatelli, G., Musolino, M., Gasbarrini, Antonio, Vetrugno G. (ORCID:0000-0003-0181-2855), Laurenti P. (ORCID:0000-0002-8532-0593), Franceschi F. (ORCID:0000-0001-6266-445X), D'Ambrosio F., la Milia D. I., Di Pumpo M., Carini E., Pascucci D. (ORCID:0000-0002-5804-2284), Boccia S. (ORCID:0000-0002-1864-749X), Pastorino R. (ORCID:0000-0001-5013-0733), Damiani G. (ORCID:0000-0003-3028-6188), De Giorgio F. (ORCID:0000-0002-9447-9707), Oliva A. (ORCID:0000-0001-7120-616X), Nicolotti N., Cambieri A., Murri R. (ORCID:0000-0003-4263-7854), Gasbarrini A. (ORCID:0000-0002-7278-4823), Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, Francesco, Foti, F., D'Ambrosio, Floriana, Cicconi, M., La Milia, Daniele Ignazio, Di Pumpo, Marcello, Carini, Elettra, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De Giorgio, Fabio, Oliva, Antonio, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R., Murri, Rita, Sabatelli, G., Musolino, M., Gasbarrini, Antonio, Vetrugno G. (ORCID:0000-0003-0181-2855), Laurenti P. (ORCID:0000-0002-8532-0593), Franceschi F. (ORCID:0000-0001-6266-445X), D'Ambrosio F., la Milia D. I., Di Pumpo M., Carini E., Pascucci D. (ORCID:0000-0002-5804-2284), Boccia S. (ORCID:0000-0002-1864-749X), Pastorino R. (ORCID:0000-0001-5013-0733), Damiani G. (ORCID:0000-0003-3028-6188), De Giorgio F. (ORCID:0000-0002-9447-9707), Oliva A. (ORCID:0000-0001-7120-616X), Nicolotti N., Cambieri A., Murri R. (ORCID:0000-0003-4263-7854), and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

OBJECTIVE: To develop a deep learning-based decision tree for the primary care setting, to stratify adult patients with confirmed and unconfirmed coronavirus disease 2019 (COVID-19), and to predict the need for hospitalization or home monitoring. PATIENTS AND METHODS: We performed a retrospective cohort study on data from patients admitted to a COVID hospital in Rome, Italy, between 5 March 2020 and 5 June 2020. A confirmed case was defined as a patient with a positive nasopharyngeal RT-PCR test result, while an unconfirmed case had negative results on repeated swabs. Patients’ medical history and clinical, laboratory and radiological findings were collected, and the dataset was used to train a predictive model for COVID-19 severity. RESULTS: Data of 198 patients were included in the study. Twenty-eight (14.14%) had mild disease, 62 (31.31%) had moderate disease, 64 (32.32%) had severe disease, and 44 (22.22%) had critical disease. The G2 value assessed the contribution of each collected value to decision tree building. On this basis, SpO2 (%) with a cut point at 92 was chosen for the optimal first split. Therefore, the decision tree was built using values maximizing G2 and LogWorth. After the tree was built, the correspondence between inputs and outcomes was validated. CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized.

Published
2021

8. A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Author

Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, C., Fantoni, Massimo, Damiani, Andrea, Marchetti, A., Sergi, P. D. A., Arcuri, G., Cesario, Alfredo, Patarnello, S., Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Anna Rita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, A. M., D'Alfonso, Maria Elena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, M., Gambassi, Giovanni, Garcovich, M., Gremese, Elisa, Grieco, D. L., Iaconelli, A., Iorio, Raffaele, Landi, Francesco, Larici, Anna Rita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gian Ludovico, Rinaldi, R., Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, A., Trani, Carlo, Varone, Francesco, Verme, L. Z. D., Murri R. (ORCID:0000-0003-4263-7854), Lenkowicz J., Masciocchi C., Fantoni M. (ORCID:0000-0001-6913-8460), Damiani A., Cesario A. (ORCID:0000-0003-4687-0709), Antonelli M. (ORCID:0000-0003-3007-1670), Bellantone R. (ORCID:0000-0002-0844-3469), Bernabei R. (ORCID:0000-0002-9197-004X), Boccia S. (ORCID:0000-0002-1864-749X), Calabresi P. (ORCID:0000-0003-0326-5509), Cambieri A., Cauda R. (ORCID:0000-0002-1498-4229), Colosimo C. (ORCID:0000-0003-3800-3648), Crea F. (ORCID:0000-0001-9404-8846), De Maria R. (ORCID:0000-0003-2255-0583), De Stefano V. (ORCID:0000-0002-5178-5827), Franceschi F. (ORCID:0000-0001-6266-445X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Parolini O. (ORCID:0000-0002-5211-6430), Richeldi L. (ORCID:0000-0001-8594-1448), Sanguinetti M. (ORCID:0000-0002-9780-7059), Urbani A. (ORCID:0000-0001-9168-3174), Zega M. (ORCID:0000-0002-7821-2615), Scambia G. (ORCID:0000-0003-2758-1063), Valentini V. (ORCID:0000-0003-4637-6487), Armuzzi A. (ORCID:0000-0003-1572-0118), Barba M. (ORCID:0000-0001-6084-7666), Baroni S. (ORCID:0000-0002-3410-2617), Bellesi S., Bentivoglio A. (ORCID:0000-0002-9663-095X), Biasucci L. M. (ORCID:0000-0002-6921-6497), Biscetti F. (ORCID:0000-0001-7449-657X), Candelli M. (ORCID:0000-0001-8443-7880), Capalbo G., Cattani P. (ORCID:0000-0003-4678-4763), Chiusolo P. (ORCID:0000-0002-1355-1587), Cingolani A. (ORCID:0000-0002-3793-2755), Corbo G. (ORCID:0000-0002-8104-4659), Covino M. (ORCID:0000-0002-6709-2531), D'Alfonso M., De Angelis G. (ORCID:0000-0002-7087-7399), De Pascale G. (ORCID:0000-0002-8255-0676), Frisullo G., Gambassi G. (ORCID:0000-0002-7030-9359), Gremese E. (ORCID:0000-0002-2248-1058), Iorio R. (ORCID:0000-0002-6270-0956), Landi F. (ORCID:0000-0002-3472-1389), Larici A. (ORCID:0000-0002-1882-6244), Liuzzo G. (ORCID:0000-0002-5714-0907), Maviglia R., Miele L. (ORCID:0000-0003-3464-0068), Montalto M. (ORCID:0000-0001-8819-3684), Natale L. (ORCID:0000-0002-7949-5119), Nicolotti N., Ojetti V. (ORCID:0000-0002-8953-0707), Pompili M. (ORCID:0000-0001-6699-7980), Posteraro B. (ORCID:0000-0002-1663-7546), Rapaccini G. (ORCID:0000-0002-6467-857X), Rossi E. (ORCID:0000-0002-7572-9379), Santoliquido A. (ORCID:0000-0003-1539-4017), Sica S. (ORCID:0000-0003-2426-3465), Tamburrini E. (ORCID:0000-0003-4930-426X), Teofili L. (ORCID:0000-0002-7214-1561), Testa A. (ORCID:0000-0003-2217-8726), Trani C. (ORCID:0000-0001-9777-013X), Varone F., Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, C., Fantoni, Massimo, Damiani, Andrea, Marchetti, A., Sergi, P. D. A., Arcuri, G., Cesario, Alfredo, Patarnello, S., Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Anna Rita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, A. M., D'Alfonso, Maria Elena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, M., Gambassi, Giovanni, Garcovich, M., Gremese, Elisa, Grieco, D. L., Iaconelli, A., Iorio, Raffaele, Landi, Francesco, Larici, Anna Rita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gian Ludovico, Rinaldi, R., Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, A., Trani, Carlo, Varone, Francesco, Verme, L. Z. D., Murri R. (ORCID:0000-0003-4263-7854), Lenkowicz J., Masciocchi C., Fantoni M. (ORCID:0000-0001-6913-8460), Damiani A., Cesario A. (ORCID:0000-0003-4687-0709), Antonelli M. (ORCID:0000-0003-3007-1670), Bellantone R. (ORCID:0000-0002-0844-3469), Bernabei R. (ORCID:0000-0002-9197-004X), Boccia S. (ORCID:0000-0002-1864-749X), Calabresi P. (ORCID:0000-0003-0326-5509), Cambieri A., Cauda R. (ORCID:0000-0002-1498-4229), Colosimo C. (ORCID:0000-0003-3800-3648), Crea F. (ORCID:0000-0001-9404-8846), De Maria R. (ORCID:0000-0003-2255-0583), De Stefano V. (ORCID:0000-0002-5178-5827), Franceschi F. (ORCID:0000-0001-6266-445X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Parolini O. (ORCID:0000-0002-5211-6430), Richeldi L. (ORCID:0000-0001-8594-1448), Sanguinetti M. (ORCID:0000-0002-9780-7059), Urbani A. (ORCID:0000-0001-9168-3174), Zega M. (ORCID:0000-0002-7821-2615), Scambia G. (ORCID:0000-0003-2758-1063), Valentini V. (ORCID:0000-0003-4637-6487), Armuzzi A. (ORCID:0000-0003-1572-0118), Barba M. (ORCID:0000-0001-6084-7666), Baroni S. (ORCID:0000-0002-3410-2617), Bellesi S., Bentivoglio A. (ORCID:0000-0002-9663-095X), Biasucci L. M. (ORCID:0000-0002-6921-6497), Biscetti F. (ORCID:0000-0001-7449-657X), Candelli M. (ORCID:0000-0001-8443-7880), Capalbo G., Cattani P. (ORCID:0000-0003-4678-4763), Chiusolo P. (ORCID:0000-0002-1355-1587), Cingolani A. (ORCID:0000-0002-3793-2755), Corbo G. (ORCID:0000-0002-8104-4659), Covino M. (ORCID:0000-0002-6709-2531), D'Alfonso M., De Angelis G. (ORCID:0000-0002-7087-7399), De Pascale G. (ORCID:0000-0002-8255-0676), Frisullo G., Gambassi G. (ORCID:0000-0002-7030-9359), Gremese E. (ORCID:0000-0002-2248-1058), Iorio R. (ORCID:0000-0002-6270-0956), Landi F. (ORCID:0000-0002-3472-1389), Larici A. (ORCID:0000-0002-1882-6244), Liuzzo G. (ORCID:0000-0002-5714-0907), Maviglia R., Miele L. (ORCID:0000-0003-3464-0068), Montalto M. (ORCID:0000-0001-8819-3684), Natale L. (ORCID:0000-0002-7949-5119), Nicolotti N., Ojetti V. (ORCID:0000-0002-8953-0707), Pompili M. (ORCID:0000-0001-6699-7980), Posteraro B. (ORCID:0000-0002-1663-7546), Rapaccini G. (ORCID:0000-0002-6467-857X), Rossi E. (ORCID:0000-0002-7572-9379), Santoliquido A. (ORCID:0000-0003-1539-4017), Sica S. (ORCID:0000-0003-2426-3465), Tamburrini E. (ORCID:0000-0003-4930-426X), Teofili L. (ORCID:0000-0002-7214-1561), Testa A. (ORCID:0000-0003-2217-8726), Trani C. (ORCID:0000-0001-9777-013X), and Varone F.

Abstract

The COVID-19 pandemic is impressively challenging the healthcare system. Several prognostic models have been validated but few of them are implemented in daily practice. The objective of the study was to validate a machine-learning risk prediction model using easy-to-obtain parameters to help to identify patients with COVID-19 who are at higher risk of death. The training cohort included all patients admitted to Fondazione Policlinico Gemelli with COVID-19 from March 5, 2020, to November 5, 2020. Afterward, the model was tested on all patients admitted to the same hospital with COVID-19 from November 6, 2020, to February 5, 2021. The primary outcome was in-hospital case-fatality risk. The out-of-sample performance of the model was estimated from the training set in terms of Area under the Receiving Operator Curve (AUROC) and classification matrix statistics by averaging the results of fivefold cross validation repeated 3-times and comparing the results with those obtained on the test set. An explanation analysis of the model, based on the SHapley Additive exPlanations (SHAP), is also presented. To assess the subsequent time evolution, the change in paO2/FiO2 (P/F) at 48 h after the baseline measurement was plotted against its baseline value. Among the 921 patients included in the training cohort, 120 died (13%). Variables selected for the model were age, platelet count, SpO2, blood urea nitrogen (BUN), hemoglobin, C-reactive protein, neutrophil count, and sodium. The results of the fivefold cross-validation repeated 3-times gave AUROC of 0.87, and statistics of the classification matrix to the Youden index as follows: sensitivity 0.840, specificity 0.774, negative predictive value 0.971. Then, the model was tested on a new population (n = 1463) in which the case-fatality rate was 22.6%. The test model showed AUROC 0.818, sensitivity 0.813, specificity 0.650, negative predictive value 0.922. Considering the first quartile of the predicted risk score (low-risk sc

Published
2021

9. Protective effect of SARS-CoV-2 preventive measures against ESKAPE and Escherichia coli infections

Author

Gaspari, Rita, Spinazzola, Giorgia, Teofili, Luciana, Avolio, Alfonso Wolfango, Fiori, Barbara, Maresca, G. M., Spanu Pennestri, Teresa, Nicolotti, Nicola, De Pascale, Gennaro, Antonelli, Massimo, Gaspari R. (ORCID:0000-0003-0141-3686), Spinazzola G. (ORCID:0000-0001-8055-5142), Teofili L. (ORCID:0000-0002-7214-1561), Avolio A. W. (ORCID:0000-0003-2491-7625), Fiori B. (ORCID:0000-0003-3318-5809), Spanu T. (ORCID:0000-0003-1864-5184), Nicolotti N., De Pascale G. (ORCID:0000-0002-8255-0676), Antonelli M. (ORCID:0000-0003-3007-1670), Gaspari, Rita, Spinazzola, Giorgia, Teofili, Luciana, Avolio, Alfonso Wolfango, Fiori, Barbara, Maresca, G. M., Spanu Pennestri, Teresa, Nicolotti, Nicola, De Pascale, Gennaro, Antonelli, Massimo, Gaspari R. (ORCID:0000-0003-0141-3686), Spinazzola G. (ORCID:0000-0001-8055-5142), Teofili L. (ORCID:0000-0002-7214-1561), Avolio A. W. (ORCID:0000-0003-2491-7625), Fiori B. (ORCID:0000-0003-3318-5809), Spanu T. (ORCID:0000-0003-1864-5184), Nicolotti N., De Pascale G. (ORCID:0000-0002-8255-0676), and Antonelli M. (ORCID:0000-0003-3007-1670)

Abstract

Background/Objectives: We investigated whether behavioral precautions adopted during Coronavirus disease (COVID-19) pandemic also influenced the spreading and multidrug resistance (MDR) of ESKAPEEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii [AB], Pseudomonas aeruginosa, Enterobacter spp and Escherichia Coli, [EC]) among Intensive Care Unit (ICU) patients. Subjects/Methods: We performed a single-center retrospective study in adult patients admitted to our COVID-19-free surgical ICU. Only patients staying in ICU for more than 48 hours were included. The ESKAPEEc infections recorded during the COVID-19 period (June 1, 2020 - February 28, 2021) and in the corresponding pre-pandemic period (June 1, 2019 - February 28, 2020) were compared. An interrupted time series analysis was performed to rule out possible confounders. Results: Overall, 173 patients in the COVID-19 period and 132 in the pre-COVID-19 period were investigated. The ESKAPEEc infections were documented in 23 (13.3%) and 35 (26.5%) patients in the pandemic and the pre-pandemic periods, respectively (p = 0.005). Demographics, diagnosis, comorbidities, type of surgery, Simplified Acute Physiology Score II, length of mechanical ventilation, hospital and ICU length of stay, ICU death rate, and 28-day hospital mortality were similar in the two groups. In comparison with the pre-pandemic period, no AB was recorded during COVID-19 period, (p = 0.017), while extended-spectrum beta-lactamase-producing EC infections significantly decreased (p = 0.017). Overall, the ESKAPEEc isolates during pandemic less frequently exhibited multidrug-resistant (p = 0.014). Conclusions: These findings suggest that a robust adherence to hygiene measures together with human contact restrictions in a COVID-19 free ICU might also restrain the transmission of ESKAPEEc pathogens.

Published
2021

10. Let‐7a‐5p, mir‐100‐5p, mir‐101‐3p, and mir‐199a‐3p hyperexpression as potential predictive biomarkers in early breast cancer patients

Author

Fuso, Paola, Di Salvatore, Mariantonietta, Santonocito, Concetta, Guarino, Donatella, Autilio, C., Mule, A., Arciuolo, Damiano, Rinninella, A., Mignone, Flavio, Ramundo, M., Di Stefano, B., Orlandi, Armando, Capoluongo, Ettore Domenico, Nicolotti, Nicola, Franceschini, Gianluca, Sanchez, A. M., Tortora, Giampaolo, Scambia, Giovanni, Barone, C., Cassano, Alessandra, Fuso P., Di Salvatore M., Santonocito C. (ORCID:0000-0003-3624-1386), Guarino D., Arciuolo D., Mignone F., Orlandi A. (ORCID:0000-0001-5253-4678), Capoluongo E. (ORCID:0000-0001-9872-0572), Nicolotti N., Franceschini G. (ORCID:0000-0002-2950-3395), Tortora G. (ORCID:0000-0002-1378-4962), Scambia G. (ORCID:0000-0003-2758-1063), Cassano A. (ORCID:0000-0002-3311-7163), Fuso, Paola, Di Salvatore, Mariantonietta, Santonocito, Concetta, Guarino, Donatella, Autilio, C., Mule, A., Arciuolo, Damiano, Rinninella, A., Mignone, Flavio, Ramundo, M., Di Stefano, B., Orlandi, Armando, Capoluongo, Ettore Domenico, Nicolotti, Nicola, Franceschini, Gianluca, Sanchez, A. M., Tortora, Giampaolo, Scambia, Giovanni, Barone, C., Cassano, Alessandra, Fuso P., Di Salvatore M., Santonocito C. (ORCID:0000-0003-3624-1386), Guarino D., Arciuolo D., Mignone F., Orlandi A. (ORCID:0000-0001-5253-4678), Capoluongo E. (ORCID:0000-0001-9872-0572), Nicolotti N., Franceschini G. (ORCID:0000-0002-2950-3395), Tortora G. (ORCID:0000-0002-1378-4962), Scambia G. (ORCID:0000-0003-2758-1063), and Cassano A. (ORCID:0000-0002-3311-7163)

Abstract

Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospec-tively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next‐Generation‐Sequencing (NGS) system. Results: Event‐free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let‐7a‐5p (EFS p = 0.006; OS p = 0.0001), mirR‐100‐5p (EFS s p = 0.01; OS p = 0.03), miR‐ 101‐3p (EFS p = 0.05; OS p = 0.01), and miR‐199a‐3p (EFS p = 0.02; OS p = 0.01) in post‐NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let‐7a‐5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up‐regulation of the above miRNAs could represent biomarkers in breast cancer.

Published
2021

11. Evaluation of kisspeptin levels in prepubertal obese and overweight children: Sexual dimorphism and modulation of antioxidant levels

Author

Mancini, Antonio, Curro', Diego, Cipolla, C., Barini, Angelina, Bruno, Carmine, Vergani, Edoardo, Segni, C. D. I., Guidi, Francesco, Nicolotti, Nicola, Silvestrini, Andrea, Meucci Calabrese, Elisabetta, Valentini, Piero, Rossodivita, Aurora Natalia, Mancini A. (ORCID:0000-0002-7707-4564), Curro D. (ORCID:0000-0001-6726-6872), Barini A. (ORCID:0000-0002-1440-5581), Bruno C., Vergani E., Guidi F., Nicolotti N., Silvestrini A. (ORCID:0000-0002-2005-3746), Meucci E. (ORCID:0000-0002-8821-8041), Valentini P. (ORCID:0000-0001-6095-9510), Rossodivita A. N., Mancini, Antonio, Curro', Diego, Cipolla, C., Barini, Angelina, Bruno, Carmine, Vergani, Edoardo, Segni, C. D. I., Guidi, Francesco, Nicolotti, Nicola, Silvestrini, Andrea, Meucci Calabrese, Elisabetta, Valentini, Piero, Rossodivita, Aurora Natalia, Mancini A. (ORCID:0000-0002-7707-4564), Curro D. (ORCID:0000-0001-6726-6872), Barini A. (ORCID:0000-0002-1440-5581), Bruno C., Vergani E., Guidi F., Nicolotti N., Silvestrini A. (ORCID:0000-0002-2005-3746), Meucci E. (ORCID:0000-0002-8821-8041), Valentini P. (ORCID:0000-0001-6095-9510), and Rossodivita A. N.

Abstract

OBJECTIVE: Kisspeptin, neuropeptide involved in puberty beginning and regulation of pituitary-gonadal axis, has been shown to stimulate antioxidant defenses in murine models. Its levels are greater in females than males and also in obese prepubertal girls. Therefore, our aim was to evaluate sex-related differences in prepubertal obese patients and the relationships of Kisspeptin with metabolic/ hormonal parameters. PATIENTS AND METHODS: We studied Kisspeptin concentrations in 54 children (22 males and 32 females, Tanner stage 1), 5-12 ys, classified according to Cole’s criteria into 17 overweight and 37 obese; 25 normal-weight children, aged 6-12 years, were studied as controls. We evaluated metabolic (glucose and insulin levels after oral glucose load, total- LDL- HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters. Moreover, total antioxidant capacity (TAC) was evaluated by spectrophotometric method, using the system H202-metmyoglobin-ABTS. Kisspeptin levels were measured by RIA. RESULTS: We did not find significant differences between obese and normal-weight children, but obese males presented significantly lower levels than females. Kisspeptin did not correlate with BMI, HOMA-IR, Insulin peak levels and TAC; a significant correlation was found between Kisspeptin and fT3 (r2=0.25; p=0.003) in the obese group; leptin levels, significantly greater in obese vs. overweight and control children, significantly correlated with TAC (r2=0.39; p=0.03). CONCLUSIONS: These data suggest that both hormones could modulate antioxidants, Kisspeptin indirectly via influence on thyroid hormones, and Leptin by a direct effect. This mechanism seems to be sex-related, not attributable to peripheral steroid levels. Further studies can clarify the complex interrelationship between central and peripheral Kisspeptin secretion and oxidative stress in children obesity.

Published
2021

12. Surgery-related complications and long-term functional morbidity after segmental colo-rectal resection for deep infiltrating endometriosis (ENDO-RESECT morb)

Author

Turco, L. C., Tortorella, L., Tuscano, A., Palumbo, M. A., Fagotti, Anna, Uccella, S., Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, Nicola, Vargiu, V., Lodoli, C., Scaldaferri, Franco, Scambia, Giovanni, Cosentino, F., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Nicolotti N., Scaldaferri F. (ORCID:0000-0001-8334-7541), Scambia G. (ORCID:0000-0003-2758-1063), Turco, L. C., Tortorella, L., Tuscano, A., Palumbo, M. A., Fagotti, Anna, Uccella, S., Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, Nicola, Vargiu, V., Lodoli, C., Scaldaferri, Franco, Scambia, Giovanni, Cosentino, F., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Nicolotti N., Scaldaferri F. (ORCID:0000-0001-8334-7541), and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

Purpose: Segmental resection has been generally associated with increased peri-operative risk of major complications. While major complications are widely acknowledged, minor complications, such as slight, to moderate infections, peripheral sensory disturbances, bladder voiding dysfunction, postoperative urinary obstruction, and sexual disorders are less reported. The aim of this study is to investigate the surgery-related complications and functional disorders, as well as to evaluate their persistence after long-term follow-up in women undergone segmental resection for deep infiltrating endometriosis. Special attention is given to evaluating impairments of bowel, bladder, and sexual function. Methods: All clinical data obtained from medical records of women who underwent segmental resection for intestinal endometriosis between October 2005, and November 2017, in Catholic University Institutions. Perioperative morbidity was classified by Extended Clavien–Dindo classification. Postoperative intestinal, voiding, and sexual morbidity was estimated by the compilation of specific questionnaires. Results: Fifty women were included in the study. Forty-three high colorectal resections (86%), 6 low resections (12%), and 1 ultra-low resection (2%) were performed, while in 3 cases (6%) multiple resections were needed. The overall complication rate was 44%. Nineteen women (38%) experienced early complications and 3 women (6%) late complications. Long-term functional postoperative complications were composed of intestinal in 30%, urinary in 50%, and sexual in 64% of the study population. Median follow-up was 55.5 months. Conclusions: Segmental resection, when indicated, offers a radical and feasible approach for bowel deep infiltrating endometriosis, resulting in an improved general quality of life. The bowel and bladder complications appear to be acceptable and often reversible. Postoperative sexual dysfunctions, such as anorgasmia and insufficient vaginal lubrication, app

Published
2020

13. Comparison of short- and long-term effectiveness of ixekizumab and secukinumab in real-world practice

Author

Caldarola, Giacomo, Mariani, M., Pirro, Federico, Nicolotti, Nicola, Burlando, M., Calabrese, L., Parodi, A., Peris, Ketty, De Simone, Clara, Caldarola G. (ORCID:0000-0002-8837-9232), Pirro F., Nicolotti N., Peris K. (ORCID:0000-0002-5237-0463), De Simone C. (ORCID:0000-0002-0898-0045), Caldarola, Giacomo, Mariani, M., Pirro, Federico, Nicolotti, Nicola, Burlando, M., Calabrese, L., Parodi, A., Peris, Ketty, De Simone, Clara, Caldarola G. (ORCID:0000-0002-8837-9232), Pirro F., Nicolotti N., Peris K. (ORCID:0000-0002-5237-0463), and De Simone C. (ORCID:0000-0002-0898-0045)

Abstract

Background: Although secukinumab and ixekizumab both act by inhibiting IL-17A, some scientific evidence suggests that there are differences in efficacy between the two agents. Objective: The aim of this study was to compare the short- and long-term effectiveness of ixekizumab and secukinumab in clinical practice. Methods: A retrospective study was conducted on a cohort of 245 psoriatic patients receiving secukinumab or ixekizumab during the period from September 2016 to December 2019. The proportion of patients achieving PASI75, PASI90, and PASI100 at weeks 12 and 24 was calculated. We recorded the 12- and 24-month drug survival as a measure to assess long-term effectiveness. Results: A higher proportion of patients in the secukinumab group achieved PASI75, 90, and 100 at 12 weeks. The Kaplan-Meier survival curve for any reason of discontinuation showed no differences between the two groups. Instead, the multivariate analysis for ineffectiveness, adjusted for potential confounders, showed a lower drug survival rate in the secukinumab group, with an adjusted HR of 2.57 (95% CI 1.05–6.28, p 0.038). Conclusion: This real-life study demonstrated that ixekizumab and secukinumab are both highly effective in short- and long-term treatment of psoriasis, even though few differences exist concerning speed of action and long-term effectiveness.

Published
2020

14. Long-term evaluation of quality of life and gastrointestinal well-being after segmental colo-rectal resection for deep infiltrating endometriosis (ENDO-RESECT QoL)

Author

Turco, L. C., Scaldaferri, Franco, Chiantera, V., Cianci, Stefano, Ercoli, A., Fagotti, Anna, Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, N., Tamburrano, A., Vargiu, V., Scambia, Giovanni, Cosentino, Francesco, Scaldaferri F. (ORCID:0000-0001-8334-7541), Cianci S., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Scambia G. (ORCID:0000-0003-2758-1063), Cosentino F., Turco, L. C., Scaldaferri, Franco, Chiantera, V., Cianci, Stefano, Ercoli, A., Fagotti, Anna, Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, N., Tamburrano, A., Vargiu, V., Scambia, Giovanni, Cosentino, Francesco, Scaldaferri F. (ORCID:0000-0001-8334-7541), Cianci S., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Scambia G. (ORCID:0000-0003-2758-1063), and Cosentino F.

Abstract

Purposes: The primary objective is to assess the long-term quality of life (QoL) and gastrointestinal well-being in patients with endometriosis (DIE) who underwent segmental resection (SR), through specific questionnaires focused on endometriosis and specific gastrointestinal evaluation. The secondary objectives are represented by the evaluation of peri-operative and post-operative outcomes of the procedure. Methods: This observational cohort study ENDO-RESECT (ClinicalTrials.gov ID: NCT03824054) reports all clinical data about women who underwent SR for DIE between October 2005 and November 2017. In the part of the study dedicated to the QoL assessment, the questionnaires adopted were the Endometriosis Health Profile (EHP30), the Psychological General Well-Being Index and the Hospital Anxiety and Depression Scale, the Gastrointestinal Well-being questionnaire and the Bristol Stool chart. Major post-surgical morbidity and obstetric outcomes were also collected. Results: 50 women (18% stage III and 82% stage IV rAFS) were considered for enrollment. EHP-30 interpretation demonstrated a significant improvement in all continuous variables, except for fertility concerns. The overall gastrointestinal QoL and most of the specific symptoms improved after surgery. Frequent bowel movements appeared in the 13% of the series not resulting in an impairment of general and gastrointestinal QoL. Constipation remained unchanged. Patients with depressive mood managed with laparoscopy, benefited the most from SR; moreover, patients with multinodular bowel localizations experienced a greater reduction in abdominal pain. Median FU after SR was 42.5 months (range 12–157 months). Only three (6%) cases of late major grade III complications were documented. The pregnancy rate was 50%. Conclusions: Improvement of general QoL and most of gastrointestinal symptoms was documented after SR.

Published
2020

15. Allogeneic cord blood transfusions prevent fetal haemoglobin depletion in preterm neonates. Results of the CB-TrIP study

Author

Teofili, Luciana, Papacci, Patrizia, Orlando, Nicoletta, Bianchi, Maria, Molisso, Anna, Purcaro, Velia, Valentini, C. G., Giannantonio, Carmen, Serrao, Francesca, Chiusolo, Patrizia, Nicolotti, Nicola, Pellegrino, C., Carducci, Brigida, Vento, Giovanni, De Stefano, Valerio, Teofili L. (ORCID:0000-0002-7214-1561), Papacci P. (ORCID:0000-0001-8236-7460), Orlando N., Bianchi M., Molisso A., Purcaro V., Giannantonio C., Serrao F., Chiusolo P. (ORCID:0000-0002-1355-1587), Nicolotti N., Carducci B., Vento G. (ORCID:0000-0002-8132-5127), De Stefano V. (ORCID:0000-0002-5178-5827), Teofili, Luciana, Papacci, Patrizia, Orlando, Nicoletta, Bianchi, Maria, Molisso, Anna, Purcaro, Velia, Valentini, C. G., Giannantonio, Carmen, Serrao, Francesca, Chiusolo, Patrizia, Nicolotti, Nicola, Pellegrino, C., Carducci, Brigida, Vento, Giovanni, De Stefano, Valerio, Teofili L. (ORCID:0000-0002-7214-1561), Papacci P. (ORCID:0000-0001-8236-7460), Orlando N., Bianchi M., Molisso A., Purcaro V., Giannantonio C., Serrao F., Chiusolo P. (ORCID:0000-0002-1355-1587), Nicolotti N., Carducci B., Vento G. (ORCID:0000-0002-8132-5127), and De Stefano V. (ORCID:0000-0002-5178-5827)

Abstract

Repeated red blood cell (RBC) transfusions in preterm neonates are associated with poor outcome and increased risk for prematurity-associated diseases. RBC transfusions cause the progressive replacement of fetal haemoglobin (HbF) by adult haemoglobin (HbA). We monitored HbF levels in 25 preterm neonates until 36 weeks of post-menstrual age (PMA); patients received RBC units from allogeneic cord blood (cord-RBCs) or from adult donors (adult-RBCs), depending on whether cord-RBCs were available. Primary outcome was HbF level at PMA of 32 weeks. Twenty-three neonates survived until this age: 14 received no transfusions, two only cord-RBCs, three only adult-RBCs and four both RBC types. HbF levels in neonates transfused with cord-RBCs were significantly higher than in neonates receiving adult-RBCs (P < 0·0001) or both RBC types (P < 0·0001). Superimposable results were obtained at PMA of 36 weeks. Every adult-RBCs transfusion increased the risk for an HbF in the lowest quartile by about 10-fold, whereas this effect was not evident if combined adult- and cord-RBCs were evaluated. Overall, these data show that transfusing cord-RBCs can limit the HbF depletion caused by conventional RBC transfusions. Transfusing cord blood warrants investigation in randomised trials as a strategy to mitigate the severity of retinopathy of prematurity (NCT03764813).

Published
2020

16. Assessment of neurological manifestations in hospitalized patients with COVID-19

Author

Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), Scaldaferri F. (ORCID:0000-0001-8334-7541), Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), and Scaldaferri F. (ORCID:0000-0001-8334-7541)

Abstract

Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.

Published
2020

17. Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis

Author

Avolio, Alfonso Wolfango, Gaspari, Rita, Teofili, Luciana, Bianco, G., Spinazzola, G., Soave, Paolo Maurizio, Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli, A., Nicolotti, Nicola, Antonelli, Massimo, Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano G., Francesconi A. G., Nicolotti N., Antonelli M. (ORCID:0000-0003-3007-1670), Avolio, Alfonso Wolfango, Gaspari, Rita, Teofili, Luciana, Bianco, G., Spinazzola, G., Soave, Paolo Maurizio, Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli, A., Nicolotti, Nicola, Antonelli, Massimo, Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano G., Francesconi A. G., Nicolotti N., and Antonelli M. (ORCID:0000-0003-3007-1670)

Abstract

Background :Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Methods: Two classification approaches were used: systematic classification (recipient-related preoperative factors; intraoperative factors; logistic factors; donor factors; postoperative ICU factors; postoperative surgical factors) and patient/organ classification (patient-related general factors; native-liver factors; new-liver factors; kidney factors; heart factors; brain factors; lung factors). Two hundred adult non-acute patients were included. Missing analysis was performed. The competitive role of each factor was assessed. Results: PRF occurred in 36.0% of cases. Among 28 significant PRF predictors at univariate analysis, 6 were excluded because of collinearity, 22 were investigated by ROC curves and by logistic regression analysis. Recipient age (OR = 1.05; p = 0.010), female sex (OR = 2.75; p = 0.018), Model for End-Stage Liver Disease (MELD, OR = 1.09; p<0.001), restrictive lung pattern (OR = 2.49; p = 0.027), intraoperative veno-venous bypass (VVBP, OR = 3.03; p = 0.008), pre-extubation PaCO 2 (OR = 1.11; p = 0.003) and Model for Early Allograft Function (MEAF, OR = 1.37; p<0.001) resulted independent PRF risk factors. As compared to patients without PRF, the PRF-group had longer LoS (10 days IQR 7-18 versus 5 days IQR 4-7, respectively; p<0.001) and lower day-90 survival (86.0% versus 97.6% respectively, p<0.001). Conclusion: In conclusion, MELD, restrictive lung pattern, surgical complexity as captured by VVBP, pre-extubation PaCO 2 and MEAF are the main predictors of PRF in non-acute LTx

Published
2019

18. Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Author

Silvestrini, Andrea, Bruno, Carmine, Vergani, E, Venuti, A, Favuzzi, Angela Maria Rita, Guidi, F, Nicolotti, Nicola, Meucci Calabrese, Elisabetta, Mordente, Alvaro, Mancini, Antonio, Silvestrini A (ORCID:0000-0002-2005-3746), Bruno C, Favuzzi AMR, Nicolotti N, Meucci E (ORCID:0000-0002-8821-8041), Mordente A (ORCID:0000-0003-3260-9796), Mancini A (ORCID:0000-0002-7707-4564), Silvestrini, Andrea, Bruno, Carmine, Vergani, E, Venuti, A, Favuzzi, Angela Maria Rita, Guidi, F, Nicolotti, Nicola, Meucci Calabrese, Elisabetta, Mordente, Alvaro, Mancini, Antonio, Silvestrini A (ORCID:0000-0002-2005-3746), Bruno C, Favuzzi AMR, Nicolotti N, Meucci E (ORCID:0000-0002-8821-8041), Mordente A (ORCID:0000-0003-3260-9796), and Mancini A (ORCID:0000-0002-7707-4564)

Abstract

Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.

Published
2019

19. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author

Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, Cillo, U, Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, Cillo U, Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, Cillo, U, Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, and Cillo U

Published
2013

20. THE UN-SUSTAINABLE MATCH IN HCV LIVER TRANSPLANT PATIENTS

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, Angelico M, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, Angelico M, Burra P, Gasbarrini A, and Cillo U

Published
2012

21. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, Cillo, U, Avolio AW, Agnes S, Lirosi M, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Romagnoli R, Vitale A, Cucchetti A, Gruttadauria S, Baccarani U, Caccamo L, Mangoni I, Pinelli D, Montalti R, Morelli N, Vennarecci G, Nicolini D, Regalia E, Lai Q, Anselmo A, Tondolo E, Perrella A, Burra P, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, Cillo, U, Avolio AW, Agnes S, Lirosi M, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Romagnoli R, Vitale A, Cucchetti A, Gruttadauria S, Baccarani U, Caccamo L, Mangoni I, Pinelli D, Montalti R, Morelli N, Vennarecci G, Nicolini D, Regalia E, Lai Q, Anselmo A, Tondolo E, Perrella A, Burra P, and Cillo U

Published
2012

22. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, and Cillo U

Published
2012

23. Use of HBcAb Positive Liver Grafts. Medium Term Results According to Donor-Recipient Risk Factors

Author

Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio A, Agnes S, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Lirosi M, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scudieri E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio A, Agnes S, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Lirosi M, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scudieri E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, and Cillo U

Published
2011

24. www.D-MELD.com. The online prognostic calculator to optimize donor-recipient match

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, and Cillo U

Published
2011

25. OPTIMIZATION OF DONOR-RECIPIENT MATCH AND IDENTIFICATION OF THE FUTILE MATCH CUTOFF. A NATIONAL ITALIAN STUDY ON LIVER TRANSPLANTATION

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Barone M, Perrella A, Romano M, de Waure C, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Barone M, Perrella A, Romano M, de Waure C, Burra P, Gasbarrini A, and Cillo U

Published
2011

26. WWW.D-MELD.COM THE PROGNOSTIC CALCULATOR TO BALANCE DONOR AND RECIPIENT LIVER TRANSPLANT FACTORS USING D-MELD AND COVARIATES

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, T, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Baccarani U, Lai Q, Manzia TM, Tondolo V, Rendina M, Scuderi V, Perrella A, Angelico M, Burra P, Fagiuoli S, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, T, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Baccarani U, Lai Q, Manzia TM, Tondolo V, Rendina M, Scuderi V, Perrella A, Angelico M, Burra P, Fagiuoli S, Gasbarrini A, and Cillo U

Published
2011

27. Erratum: Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium (European Journal of Epidemiology DOI: 10.1007/s10654-011- 9612-3)

Author

Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., and Boccia S. (ORCID:0000-0002-1864-749X)

Published
2011

28. Prediction of Outcome after Liver Transplantation by D-MELD. Stratification of Graft Survival According to Donor Recipient Match in the Italian Multicenter Study

Author

Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Risaliti, A, Bresadola, V, Gridelli, B, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Boscarino, G, Nicolotti, N, Nicolini, D, Baccarani, U, Gruttadauria, S, Regalia, E, Angelico, M, Gasbarrini, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Risaliti A, Bresadola V, Gridelli B, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Boscarino G, Nicolotti N, Nicolini D, Baccarani U, Gruttadauria S, Regalia E, Angelico M, Gasbarrini A, Agnes S, Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Risaliti, A, Bresadola, V, Gridelli, B, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Boscarino, G, Nicolotti, N, Nicolini, D, Baccarani, U, Gruttadauria, S, Regalia, E, Angelico, M, Gasbarrini, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Risaliti A, Bresadola V, Gridelli B, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Boscarino G, Nicolotti N, Nicolini D, Baccarani U, Gruttadauria S, Regalia E, Angelico M, Gasbarrini A, and Agnes S

Published
2010

29. D-MELD, a Powerful Predictor of Graft Survival after Liver Transplantation. Long-Term Results of a Multicenter Italian Study

Author

Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Grieco, A, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Angeli, P, Corno, V, Antonelli, B, Gaspari, R, Gelli, M, Boscarino, G, Nicolotti, N, Costa, R, Angelico, M, Corradini, S, Gasbarrini, A, Di Leo, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Grieco A, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Angeli P, Corno V, Antonelli B, Gaspari R, Gelli M, Boscarino G, Nicolotti N, Costa R, Angelico M, Corradini SG, Gasbarrini A, Di Leo A, Agnes S, Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Grieco, A, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Angeli, P, Corno, V, Antonelli, B, Gaspari, R, Gelli, M, Boscarino, G, Nicolotti, N, Costa, R, Angelico, M, Corradini, S, Gasbarrini, A, Di Leo, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Grieco A, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Angeli P, Corno V, Antonelli B, Gaspari R, Gelli M, Boscarino G, Nicolotti N, Costa R, Angelico M, Corradini SG, Gasbarrini A, Di Leo A, and Agnes S

Published
2010

30. Health Technology Assessment evaluation of the 13-valent pneumococcal conjugate vaccine in the adult and elderly population

Author

Specchia, Maria Lucia, De Waure, Chiara, Kheiraoui, F, Mantovani, L, Di Pietro, Maria Luisa, Cadeddu, Chiara, Di Nardo, Francesco, Ferriero, Anna Maria, Capizzi, Silvio, Gualano, Mr, Nicolotti, N, Sferrazza, A, Veneziano, Maria Assunta, Saulle, R, Gliubizzi, Maria Daniela, La Torre, G, Ricciardi, Walter, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Specchia, Maria Lucia, De Waure, Chiara, Kheiraoui, F, Mantovani, L, Di Pietro, Maria Luisa, Cadeddu, Chiara, Di Nardo, Francesco, Ferriero, Anna Maria, Capizzi, Silvio, Gualano, Mr, Nicolotti, N, Sferrazza, A, Veneziano, Maria Assunta, Saulle, R, Gliubizzi, Maria Daniela, La Torre, G, Ricciardi, Walter, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

31. Assessing medical devices: threats and opportunities in the evaluation of the value of new technologies in different fields

Author

Kheiraoui, F, De Waure, Chiara, Specchia, Maria Lucia, Capri, S, Capizzi, Silvio, Cadeddu, Chiara, Veneziano, Maria Assunta, Di Nardo, Francesco, Nicolotti, N, Gualano, Mr, Gliubizzi, Maria Daniela, Mancuso, Agostino, Avallone, G, Di Pietro, Maria Luisa, La Torre, G, Ricciardi, Gualtiero, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Kheiraoui, F, De Waure, Chiara, Specchia, Maria Lucia, Capri, S, Capizzi, Silvio, Cadeddu, Chiara, Veneziano, Maria Assunta, Di Nardo, Francesco, Nicolotti, N, Gualano, Mr, Gliubizzi, Maria Daniela, Mancuso, Agostino, Avallone, G, Di Pietro, Maria Luisa, La Torre, G, Ricciardi, Gualtiero, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

32. A new drug responding an unmet need: belimumab in the treatment of systemic lupus erythematosus

Author

De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Doria, A, Turchetti, G, Capizzi, Silvio, Iaccarino, L, Pierotti, F, Kheiraoui, F, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Palla, I, Di Nardo, Francesco, Gliubizzi, Maria Daniela, Sferrazza, Antonella, Nicolotti, N, Gualano, Mr, La Torre, G, Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Doria, A, Turchetti, G, Capizzi, Silvio, Iaccarino, L, Pierotti, F, Kheiraoui, F, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Palla, I, Di Nardo, Francesco, Gliubizzi, Maria Daniela, Sferrazza, Antonella, Nicolotti, N, Gualano, Mr, La Torre, G, Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

33. Health Technology Assessment evaluation of the 13-valent pneumococcal conjugate vaccine in the adult and elderly population

Author

Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Kheiraoui, F, Mantovani, L, Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Nardo, Francesco, Ferriero, Anna Maria, Capizzi, Silvio, Gualano, Mr, Nicolotti, N, Sferrazza, A, Veneziano, Maria Assunta, Saulle, R, Gliubizzi, Maria Daniela, La Torre, G, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Kheiraoui, F, Mantovani, L, Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Nardo, Francesco, Ferriero, Anna Maria, Capizzi, Silvio, Gualano, Mr, Nicolotti, N, Sferrazza, A, Veneziano, Maria Assunta, Saulle, R, Gliubizzi, Maria Daniela, La Torre, G, and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

34. The 13-valent pneumococcal conjugated vaccine introduction in subjects aged >50 years: the result of a Health Technology Assessment

Author

Kheiraoui, F, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Mantovani, L, Capizzi, Silvio, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Nardo, Francesco, Ferriero, Anna Maria, Veneziano, Maria Assunta, Furneri, G, Gualano, Mr, Nicolotti, N, Sferrazza, A, Refolo, Pietro (ORCID:0000-0003-1055-160X), Gliubizzi, Maria Daniela, Saulle, R, La Torre, G, Ricciardi, Arturo, Kheiraoui, F, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Mantovani, L, Capizzi, Silvio, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Nardo, Francesco, Ferriero, Anna Maria, Veneziano, Maria Assunta, Furneri, G, Gualano, Mr, Nicolotti, N, Sferrazza, A, Refolo, Pietro (ORCID:0000-0003-1055-160X), Gliubizzi, Maria Daniela, Saulle, R, La Torre, G, and Ricciardi, Arturo

Abstract

Nessuno

Published
2013

35. Health Technology Assessment evaluation of the 13-valent pneumococcal conjugate vaccine in the adult and elderly population

Author

Specchia, Maria Lucia, De Waure, Chiara, Kheiraoui, F, Mantovani, L, Di Pietro, Maria Luisa, Cadeddu, Chiara, Di Nardo, Francesco, Ferriero, Anna Maria, Capizzi, Silvio, Gualano, Mr, Nicolotti, N, Sferrazza, A, Veneziano, Maria Assunta, Saulle, R, Gliubizzi, Maria Daniela, La Torre, G, Ricciardi, Walter, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Specchia, Maria Lucia, De Waure, Chiara, Kheiraoui, F, Mantovani, L, Di Pietro, Maria Luisa, Cadeddu, Chiara, Di Nardo, Francesco, Ferriero, Anna Maria, Capizzi, Silvio, Gualano, Mr, Nicolotti, N, Sferrazza, A, Veneziano, Maria Assunta, Saulle, R, Gliubizzi, Maria Daniela, La Torre, G, Ricciardi, Walter, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

36. Health Technology Assessment di AdvateTM (octocog alfa) per la profilassi del sanguinamento nei pazienti con Emofilia A. Ann Ig 2013; 25 (Suppl. 1): 1-7

Author

Capizzi, Silvio, Capri, S, Specchia, Maria Lucia, De Waure, Chiara, Veneziano, Maria Assunta, Kheiraoui, F, Gualano, Mr, Nicolotti, N, Sferrazza, A, Cadeddu, Chiara, Di Nardo, Francesco, Di Pietro, Maria Luisa, La Torre, G, Ricciardi, Gualtiero, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Capizzi, Silvio, Capri, S, Specchia, Maria Lucia, De Waure, Chiara, Veneziano, Maria Assunta, Kheiraoui, F, Gualano, Mr, Nicolotti, N, Sferrazza, A, Cadeddu, Chiara, Di Nardo, Francesco, Di Pietro, Maria Luisa, La Torre, G, Ricciardi, Gualtiero, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

This study aimed at assessing the global value of AdvateTM, antihaemophilic recombinant factor for bleeding prevention and control in Haemophilia A. Epidemiological, clinical, organizational and social and ethical data related to available Haemophilia treatments were considered. Scientific literature reviews were conducted through all main electronic databases. A cost-effectiveness analysis (CEA) from the perspective of the National Health Service (NHS) was performed in order to calculate the incremental cost-effectiveness ratio (ICER) comparing the use of octocog alfa in primary prophylaxis vs on-demand treatment. In the world, patients with Haemophilia A are approximately 110,000 (about 3700 in Italy). Prophylaxis,compared to on-demand treatment, is proven to be more effective for prevention of bleedings and related complications, but also moderately more expensive (ICER= €35,036/QALY). The introduction of totally protein-free full length recombinant FVIII concentrates (AdvateTM), eliminated risks of blood-borne pathogens transmission. This induced a broader adoption of prophylaxis improving efficacy of treatment and patients’ Quality of Life (QoL). Also, since Baxter, AdvatÈs manufacturer and distributor, offers collateral free of charge services to patients (home delivery, home rehabilitation assistance, home nursing, telemedicine), the HTA looks at how all these services generate savings for the healthcare authorities while increasing the level of assistance. The evidence provided by HTA should be taken into account by decision-makers to improve the allocation of resources and rationalize health choices.

Published
2013

37. Assessing medical devices: threats and opportunities in the evaluation of the value of new technologies in different fields

Author

Kheiraoui, F, De Waure, Chiara, Specchia, Maria Lucia, Capri, S, Capizzi, Silvio, Cadeddu, Chiara, Veneziano, Maria Assunta, Di Nardo, Francesco, Nicolotti, N, Gualano, Mr, Gliubizzi, Maria Daniela, Mancuso, Agostino, Avallone, G, Di Pietro, Maria Luisa, La Torre, G, Ricciardi, Gualtiero, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Kheiraoui, F, De Waure, Chiara, Specchia, Maria Lucia, Capri, S, Capizzi, Silvio, Cadeddu, Chiara, Veneziano, Maria Assunta, Di Nardo, Francesco, Nicolotti, N, Gualano, Mr, Gliubizzi, Maria Daniela, Mancuso, Agostino, Avallone, G, Di Pietro, Maria Luisa, La Torre, G, Ricciardi, Gualtiero, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

38. A retrospective analysis of 3156 admissions with fever of unknown origin in a large Italian hospital.

Author

Nicolotti, N, Cattel, Caterina, Gualano, Mr, Soriano, Alessandra, Manna, Raffaele, Boccia, Stefania, Manna, Raffaele (ORCID:0000-0003-1560-3907), Boccia, Stefania (ORCID:0000-0002-1864-749X), Nicolotti, N, Cattel, Caterina, Gualano, Mr, Soriano, Alessandra, Manna, Raffaele, Boccia, Stefania, Manna, Raffaele (ORCID:0000-0003-1560-3907), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

Background: fever of unknown origin (FUO) is defined as a fever with no etiologic diagnosis after standardized investigations performed during 3 days in hospital or after at least 3 ambulatory visits. Our study aims to describe the epidemiology of classic FUO through the retrospective analysis of 902 861 admissions to a large University Hospital in Italy, to investigate its temporal trend, and to evaluate differences between young and old patients. Methods: we retrieved data records of all the admissions between the 1st January 1988 and 31st December 2007. Proportional admission rate (PAR) of FUO was calculated. Time trends of FUO admissions were analysed by joinpoint regression, with time changes expressed as Expected Annual Percent Change (EA PC). The ICD 9-CM code was used to identify the diagnosis on discharge of FUO cases. Results: in the study period 3 156 patients were admitted with a diagnosis of FUO (PAR=3.50 per 1 000). The time-trend analysis showed two joinpoints, the first in 1995 (EAPC of 307.80, 95% CI: 89.66-776.84, p=0.002), and the second in 1998 (EAPC=-8.57, 95% CI: -10.37-6.73; p<0.001). Around 22% of admissions remained without a definitive diagnosis of FUO, with this percentage being lower in patients ≥65 years compared with subjects aged 21-64. ConclusionS: FUO is a leading cause of admission to hospitals, as well as of morbidity and mortality, thus representing a challenge for diagnostic medicine and hospital care. It is necessary to develop a diagnostic methodology for FUO, so as to reduce costs of preventable hospitalizations.

Published
2013

39. Aspetti organizzativi relativi all’impiego nell’adulto di Prevenar 13 nel contesto di cura italiano, in Il vaccino pneumococcico 13-valente per la prevenzione delle infezioni da S. pneumoniae in età adulta: una valutazione di HTA

Author

Capizzi, Silvio, Ferriero, Anna Maria, Kheiraoui, F, Nicolotti, N, Veneziano, Maria Assunta, Gualano, Mr, Gliubizzi, Maria Daniela, De Waure, Chiara, Saulle, R, La Torre, G, Specchia, Maria Lucia, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Capizzi, Silvio, Ferriero, Anna Maria, Kheiraoui, F, Nicolotti, N, Veneziano, Maria Assunta, Gualano, Mr, Gliubizzi, Maria Daniela, De Waure, Chiara, Saulle, R, La Torre, G, Specchia, Maria Lucia, De Waure, Chiara (ORCID:0000-0002-4346-1494), and Specchia, Maria Lucia (ORCID:0000-0002-3859-4591)

Abstract

In linea con la crescente importanza data alla prevenzione, nei Paesi sviluppati è oggi sempre più avvertita la necessità di mettere a punto strategie efficaci per un’adeguata profilassi vaccinale della popolazione adulta al pari di quella pediatrica, in considerazione anche delle attuali variazioni dei trend demografici. Tra le vaccinazioni di particolare interesse per la popolazione adulta/anziana, quella antipneumococcica riveste, sicuramente, un ruolo di rilevanza primaria. In relazione al carico di malattia legato alle infezioni da S.Pneumoniae, appare pertanto opportuna una riflessione in merito alla necessità di estendere il target della vaccinazione a tutta la popolazione over 50

Published
2013

40. A new drug responding an unmet need: belimumab in the treatment of systemic lupus erythematosus

Author

De Waure, Chiara, Specchia, Maria Lucia, Doria, A, Turchetti, G, Capizzi, Silvio, Iaccarino, L, Pierotti, F, Kheiraoui, F, Cadeddu, Chiara, Palla, I, Di Nardo, Francesco, Gliubizzi, Maria Daniela, Sferrazza, Antonella, Nicolotti, N, Gualano, Mr, La Torre, G, Di Pietro, Maria Luisa, Ricciardi, Walter, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), De Waure, Chiara, Specchia, Maria Lucia, Doria, A, Turchetti, G, Capizzi, Silvio, Iaccarino, L, Pierotti, F, Kheiraoui, F, Cadeddu, Chiara, Palla, I, Di Nardo, Francesco, Gliubizzi, Maria Daniela, Sferrazza, Antonella, Nicolotti, N, Gualano, Mr, La Torre, G, Di Pietro, Maria Luisa, Ricciardi, Walter, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

41. The 13-valent pneumococcal conjugated vaccine introduction in subjects aged >50 years: the result of a Health Technology Assessment

Author

Kheiraoui, F, De Waure, Chiara, Specchia, Maria Lucia, Di Pietro, Maria Luisa, Mantovani, L, Capizzi, Silvio, Cadeddu, Chiara, Di Nardo, Francesco, Ferriero, Anna Maria, Veneziano, Maria Assunta, Furneri, G, Gualano, Mr, Nicolotti, N, Sferrazza, A, Refolo, Pietro, Gliubizzi, Maria Daniela, Saulle, R, La Torre, G, Ricciardi, Arturo, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Refolo, Pietro (ORCID:0000-0003-1055-160X), Kheiraoui, F, De Waure, Chiara, Specchia, Maria Lucia, Di Pietro, Maria Luisa, Mantovani, L, Capizzi, Silvio, Cadeddu, Chiara, Di Nardo, Francesco, Ferriero, Anna Maria, Veneziano, Maria Assunta, Furneri, G, Gualano, Mr, Nicolotti, N, Sferrazza, A, Refolo, Pietro, Gliubizzi, Maria Daniela, Saulle, R, La Torre, G, Ricciardi, Arturo, De Waure, Chiara (ORCID:0000-0002-4346-1494), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Di Pietro, Maria Luisa (ORCID:0000-0002-3893-8788), Cadeddu, Chiara (ORCID:0000-0003-0149-1078), and Refolo, Pietro (ORCID:0000-0003-1055-160X)

Abstract

Nessuno

Published
2013

42. Health technology assessment of fostimon, a highly purified human-derived urofollitropin for the treatment of infertility

Author

Cadeddu, Chiara, Specchia, Maria Lucia, De Waure, Chiara, Di Nardo, Francesco, Capizzi, Silvio, Capri, S, Gualano, Mr, Nicolotti, N, Kheiraoui, F, Sferrazza, A, Mancuso, Agostino, Avallone, G, La Torre, G, Ricciardi, Walter, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadeddu, Chiara, Specchia, Maria Lucia, De Waure, Chiara, Di Nardo, Francesco, Capizzi, Silvio, Capri, S, Gualano, Mr, Nicolotti, N, Kheiraoui, F, Sferrazza, A, Mancuso, Agostino, Avallone, G, La Torre, G, Ricciardi, Walter, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), De Waure, Chiara (ORCID:0000-0002-4346-1494), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

Nessuno

Published
2013

43. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls

Author

Simone, B, De Stefano, Valerio, Leoncini, E, Zacho, J, Martinelli, I, Emmerich, J, Rossi, Elena, Folsom, Ar, Almawi, Wy, Scarabin, Py, Den Heijer, M, Cushman, M, Penco, S, Vaya, A, Angchaisuksiri, P, Okumus, G, Gemmati, D, Cima, S, Akar, N, Oguzulgen, Ki, Ducros, V, Lichy, C, Fernandez Miranda, C, Szczeklik, A, Nieto, Ja, Torres, Jd, Le Cam Duchez, V, Ivanov, P, Cantu Brito, C, Shmeleva, Vm, Stegnar, M, Ogunyemi, D, Eid, S, Nicolotti, N, De Feo, E, Ricciardi, W, Boccia, Stefania, De Stefano, Valerio (ORCID:0000-0002-5178-5827), Rossi, Elena (ORCID:0000-0002-7572-9379), Simone, B, De Stefano, Valerio, Leoncini, E, Zacho, J, Martinelli, I, Emmerich, J, Rossi, Elena, Folsom, Ar, Almawi, Wy, Scarabin, Py, Den Heijer, M, Cushman, M, Penco, S, Vaya, A, Angchaisuksiri, P, Okumus, G, Gemmati, D, Cima, S, Akar, N, Oguzulgen, Ki, Ducros, V, Lichy, C, Fernandez Miranda, C, Szczeklik, A, Nieto, Ja, Torres, Jd, Le Cam Duchez, V, Ivanov, P, Cantu Brito, C, Shmeleva, Vm, Stegnar, M, Ogunyemi, D, Eid, S, Nicolotti, N, De Feo, E, Ricciardi, W, Boccia, Stefania, De Stefano, Valerio (ORCID:0000-0002-5178-5827), and Rossi, Elena (ORCID:0000-0002-7572-9379)

Abstract

Genetic and environmental factors interact in determining the risk of venous thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor V (Factor V Leiden, FVL), G20210A of prothrombin (PT20210A) and C677T of methylentetrahydrofolate reductase (C677T MTHFR) genes has been investigated in many studies. We performed a pooled analysis of case-control and cohort studies investigating in adults the association between each variant and VTE, published on Pubmed, Embase or Google through January 2010. Authors of eligible papers, were invited to provide all available individual data for the pooling. The Odds Ratio (OR) for first VTE associated with each variant, individually and combined with the others, were calculated with a random effect model, in heterozygotes and homozygotes (dominant model for FVL and PT20210A; recessive for C677T MTHFR). We analysed 31 databases, including 11,239 cases and 21,521 controls. No significant association with VTE was found for homozygous C677T MTHFR (OR: 1.38; 95 % confidence intervals [CI]: 0.98-1.93), whereas the risk was increased in carriers of either heterozygous FVL or PT20210 (OR = 4.22; 95 % CI: 3.35-5.32; and OR = 2.79;95 % CI: 2.25-3.46, respectively), in double heterozygotes (OR = 3.42; 95 %CI 1.64-7.13), and in homozygous FVL or PT20210A (OR = 11.45; 95 %CI: 6.79-19.29; and OR: 6.74 (CI 95 % 2.19-20.72), respectively). The stratified analyses showed a stronger effect of FVL on individuals ≤ 45 years (p value for interaction = 0.036) and of PT20210A in women using oral contraceptives (p-value for interaction = 0.045). In this large pooled analysis, inclusive of large studies like MEGA, no effect was found for C677T MTHFR on VTE; FVL and PT20210A were confirmed to be moderate risk factors. Notably, double carriers of the two genetic variants produced an impact on VTE risk significantly increased

Published
2013

44. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls

Author

Simone, Benedetto, De Stefano, E, Leoncini, Emanuele, Zacho, J, Martinelli, I, Emmerich, J, Rossi, E, Folsom, Ar, Almawi, Wy, Scarabin, Py, Den Heijer, M, Cushman, M, Penco, S, Vaya, A, Angchaisuksiri, P, Okumus, G, Gemmati, D, Cima, S, Akar, N, Oguzulgen, Ki, Ducros, V, Lichy, C, Fernandez Miranda, C, Szczeklik, A, Nieto, Ja, Torres, Jd, Cam Duchez, V, Ivanov, P, Cantu Brito, C, Shmeleva, Vm, Stegnar, M, Ogunyemi, D, Eid, S, Nicolotti, N, De Feo, Emma, Ricciardi, Walter, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Simone, Benedetto, De Stefano, E, Leoncini, Emanuele, Zacho, J, Martinelli, I, Emmerich, J, Rossi, E, Folsom, Ar, Almawi, Wy, Scarabin, Py, Den Heijer, M, Cushman, M, Penco, S, Vaya, A, Angchaisuksiri, P, Okumus, G, Gemmati, D, Cima, S, Akar, N, Oguzulgen, Ki, Ducros, V, Lichy, C, Fernandez Miranda, C, Szczeklik, A, Nieto, Ja, Torres, Jd, Cam Duchez, V, Ivanov, P, Cantu Brito, C, Shmeleva, Vm, Stegnar, M, Ogunyemi, D, Eid, S, Nicolotti, N, De Feo, Emma, Ricciardi, Walter, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

Genetic and environmental factors interact in determining the risk of venous thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor V (Factor V Leiden, FVL), G20210A of prothrombin (PT20210A) and C677T of methylentetrahydrofolate reductase (C677T MTHFR) genes has been investigated in many studies. We performed a pooled analysis of case-control and cohort studies investigating in adults the association between each variant and VTE, published on Pubmed, Embase or Google through January 2010. Authors of eligible papers, were invited to provide all available individual data for the pooling. The Odds Ratio (OR) for first VTE associated with each variant, individually and combined with the others, were calculated with a random effect model, in heterozygotes and homozygotes (dominant model for FVL and PT20210A; recessive for C677T MTHFR). We analysed 31 databases, including 11,239 cases and 21,521 controls. No significant association with VTE was found for homozygous C677T MTHFR (OR: 1.38; 95 % confidence intervals [CI]: 0.98-1.93), whereas the risk was increased in carriers of either heterozygous FVL or PT20210 (OR = 4.22; 95 % CI: 3.35-5.32; and OR = 2.79;95 % CI: 2.25-3.46, respectively), in double heterozygotes (OR = 3.42; 95 %CI 1.64-7.13), and in homozygous FVL or PT20210A (OR = 11.45; 95 %CI: 6.79-19.29; and OR: 6.74 (CI 95 % 2.19-20.72), respectively). The stratified analyses showed a stronger effect of FVL on individuals ≤ 45 years (p value for interaction = 0.036) and of PT20210A in women using oral contraceptives (p-value for interaction = 0.045). In this large pooled analysis, inclusive of large studies like MEGA, no effect was found for C677T MTHFR on VTE; FVL and PT20210A were confirmed to be moderate risk factors. Notably, double carriers of the two genetic variants produced an impact on VTE risk significantly increased but weaker than previously thought.

Published
2013

45. From Nicotine Dependence to Genetic Determinants of Smoking

Author

Torre, G, Saulle, R, Nicolotti, N, De Waure, Chiara, Gualano, Mr, Boccia, Stefania, De Waure, Chiara (ORCID:0000-0002-4346-1494), Boccia, Stefania (ORCID:0000-0002-1864-749X), Torre, G, Saulle, R, Nicolotti, N, De Waure, Chiara, Gualano, Mr, Boccia, Stefania, De Waure, Chiara (ORCID:0000-0002-4346-1494), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

The goal of this chapter is to introduce the reader to the world of tobacco smoking, the role of nicotine in inducing a nicotine addiction, as well as to be confident with some tools in measuring nicotine dependence and motivation to quit. Moreover, it will serve to give an update overview about genetic risk factors for smoking behavior going in depth with molecular and biological aspects and to describe the role of genetic determinants in initiation and cessation of cigarette smoking.

Published
2013

46. Balancing Donor and Recipient Risk Factors in Liver Transplantation: The Value of D-MELD With Particular Reference to HCV Recipients

Author

Avolio, Alfonso Wolfango, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, Ge, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, Nicola, Burra, P, Gasbarrini, Antonio, Agnes, Salvatore, Lirosi, Mc, Miele, Luca, Pompili, Maurizio, Siciliano, M, Perilli, Valter, Gaspari, Rita, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, Ad, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, Stefano, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, Vincenzo, Ettorre, Gm, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, Pl, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, de Ville de Goyet, J, Monti, L, De Waure, Chiara, Avolio, AW (ORCID:0000-0003-2491-7625), Nicolotti, N, Gasbarrini, A (ORCID:0000-0002-7278-4823), Agnes, S (ORCID:0000-0002-3341-4221), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Perilli, V (ORCID:0000-0001-9655-4267), Gaspari, R (ORCID:0000-0003-0141-3686), Fagiuoli, S, Tondolo, V (ORCID:0000-0003-0256-3766), de Waure, C (ORCID:0000-0002-4346-1494), Avolio, Alfonso Wolfango, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, Ge, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, Nicola, Burra, P, Gasbarrini, Antonio, Agnes, Salvatore, Lirosi, Mc, Miele, Luca, Pompili, Maurizio, Siciliano, M, Perilli, Valter, Gaspari, Rita, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, Ad, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, Stefano, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, Vincenzo, Ettorre, Gm, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, Pl, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, de Ville de Goyet, J, Monti, L, De Waure, Chiara, Avolio, AW (ORCID:0000-0003-2491-7625), Nicolotti, N, Gasbarrini, A (ORCID:0000-0002-7278-4823), Agnes, S (ORCID:0000-0002-3341-4221), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Perilli, V (ORCID:0000-0001-9655-4267), Gaspari, R (ORCID:0000-0003-0141-3686), Fagiuoli, S, Tondolo, V (ORCID:0000-0003-0256-3766), and de Waure, C (ORCID:0000-0002-4346-1494)

Abstract

Donorrecipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5yrsPS<50%) was investigated. A prognosis calculator was implemented (). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.442.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.1-11.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.592.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.290.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5yrsPS<50% cutoff was identified only in HCV patients (D-MELD = 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients.

Published
2011

47. Balancing donor and recipient risk factors in liver transplantation: The value of D-MELD with particular reference to HCV recipients

Author

Avolio, A, Cillo, U, Salizzoni, M, DE CARLIS, L, Colledan, M, Gerunda, G, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, M, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Lupo, F, Tandoi, F, De Carlis, L, Mangoni, I, Belli, L, Pinna, A, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, S, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, G, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, P, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, De Waure, C, DE CARLIS, LUCIANO GREGORIO, De Waure, C., Avolio, A, Cillo, U, Salizzoni, M, DE CARLIS, L, Colledan, M, Gerunda, G, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, M, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Lupo, F, Tandoi, F, De Carlis, L, Mangoni, I, Belli, L, Pinna, A, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, S, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, G, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, P, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, De Waure, C, DE CARLIS, LUCIANO GREGORIO, and De Waure, C.

Abstract

Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5 yrs PS<50%) was investigated. A prognosis calculator was implemented (www.D-MELD.com). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS<50% cutoff was identified only in HCV patients (D-MELD ≥ 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients

Published
2011

48. Quality evaluation of guidelines on genetic screening, surveillance and management of hereditary colorectal cancer

Author

Simone, Benedetto, De Feo, E, Nicolotti, N, Ricciardi, Walter, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Simone, Benedetto, De Feo, E, Nicolotti, N, Ricciardi, Walter, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

BACKGROUND: We examined the methodological quality of guidelines on colorectal cancer genetic susceptibility syndromes. METHODS: PubMed, EMBASE, and Google were searched up to July 2010. Adjourned guidelines in English were included. The Appraisal of Guidelines, Research and Evaluation (AGREE) instrument was used to assess their quality, and the reported evidence base of the guidelines was evaluated. RESULTS: The search yielded 17 eligible guidelines: 11 were developed by independent associations, while 6 had national\state endorsement. Only three guidelines performed satisfactorily, achieving a score >50% in all 6 AGREE domains. Mean standardized scores for the 6 AGREE domains were: 'scope and purpose', 83.9 ± 22.5%; 'stakeholder involvement', 35.6 ± 24.9%; 'rigour of development', 48.6 ± 25.3%; 'clarity and presentation', 71.6 ± 19.3%; 'applicability', 33.8 ± 30.1%; 'editorial independence', 42.2 ± 39.7%. Guidelines with national endorsement performed better in all the domains, with a statistically significant difference in three domains. Fifteen guidelines out of 17 were found to be based on research evidence. CONCLUSIONS: There is scope, in many areas, for improving the guidelines analysed, among which are the involvement of various professional figures and patients' representatives, and policies for their application. The AGREE instrument is a useful tool and could also be used profitably by guideline developers to improve the quality of recommendations.

Published
2011

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