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2 results on '"Ndounga, Mathieu"'

1. Evidence for the transmission of Plasmodium vivax in the Republic of the Congo, West Central Africa.

Author

Culleton, Richard, Ndounga, Mathieu, Zeyrek, Fadile Yildiz, Coban, Cevayir, Casimiro, Prisca Nadine, Takeo, Satoru, Tsuboi, Takafumi, Yadava, Anjali, Carter, Richard, Tanabe, Kazuyuki, Culleton, Richard, Ndounga, Mathieu, Zeyrek, Fadile Yildiz, Coban, Cevayir, Casimiro, Prisca Nadine, Takeo, Satoru, Tsuboi, Takafumi, Yadava, Anjali, Carter, Richard, and Tanabe, Kazuyuki

Abstract

Plasmodium vivax is not thought to be transmitted in western and central Africa, because of the very high prevalence of the red blood cell Duffy-negative phenotype in local populations, a condition which is thought to confer complete resistance against blood infection with P. vivax. There are, however, persistent reports of travelers returning from this region with P. vivax infections. To investigate whether transmission occurs in this region, the presence of antibodies specific to P. vivax preerythrocytic-stage antigens was assessed in individuals from the Republic of the Congo. A total of 55 (13%) of 409 samples tested by enzyme-linked immunosorbent assay had antibodies to P. vivax-specific antigens., The Journal of infectious diseases, 200(9), pp.1465-1469; 2009

Published
2009

2. Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing

Author

Culleton, Richard L, Mita, Toshihiro, Ndounga, Mathieu, Unger, Holger, Cravo, Pedro VL, Paganotti, Giacomo M, Takahashi, Nobuyuki, Kaneko, Akira, Eto, Hideaki, Tinto, Halidou, Karema, Corine, D'Alessandro, Umberto, Rosario, Virgilio do, Kobayakawa, Takatoshi, Ntoumi, Francine, Carter, Richard, Tanabe, Kazuyuki, Culleton, Richard L, Mita, Toshihiro, Ndounga, Mathieu, Unger, Holger, Cravo, Pedro VL, Paganotti, Giacomo M, Takahashi, Nobuyuki, Kaneko, Akira, Eto, Hideaki, Tinto, Halidou, Karema, Corine, D'Alessandro, Umberto, Rosario, Virgilio do, Kobayakawa, Takatoshi, Ntoumi, Francine, Carter, Richard, and Tanabe, Kazuyuki

Abstract

BACKGROUND: Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. METHODS: Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. RESULTS: Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. CONCLUSION: The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers., Malaria Journal, 7, 174; 2008

Published
2008

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