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5 results on '"Naggara, O."'

1. Risk factors of unexplained early neurological deterioration after treatment for ischemic stroke due to large vessel occlusion: a post hoc analysis of the HERMES study

Author

Bourcier, R., Goyal, M., Muir, K.W., Desal, H., Dippel, D.W.J., Majoie, C.B.L.M., van Zwam, W.H., Jovin, T.G., Mitchell, P.J., Demchuk, A.M., van Oostenbrugge, R.J., Brown, S.B., Campbell, B., White, P., Hill, M.D., Saver, J.L., Weimar, C., Jahan, R., Guillemin, F., Bracard, S., Naggara, O., HERMES Trialists Collaboration, Bourcier, R., Goyal, M., Muir, K.W., Desal, H., Dippel, D.W.J., Majoie, C.B.L.M., van Zwam, W.H., Jovin, T.G., Mitchell, P.J., Demchuk, A.M., van Oostenbrugge, R.J., Brown, S.B., Campbell, B., White, P., Hill, M.D., Saver, J.L., Weimar, C., Jahan, R., Guillemin, F., Bracard, S., Naggara, O., and HERMES Trialists Collaboration

Abstract

Background: Early neurological deterioration (END) after endovascular treatment (EVT) in patients with anterior circulation acute ischemic stroke (AIS) is associated with poor outcome. END may remain unexplained by parenchymal hemorrhage (UnEND). We aim to analyze the risk factors of UnEND in the medical management (MM) and EVT arms of the HERMES study. Methods: We conducted a post-hoc analysis of anterior AIS patients who underwent EVT for proximal anterior occlusions. Risk factors of UnEND, defined as a worsening of ≥4 points between baseline National Institutes of Health Stroke Scale (NIHSS) and NIHSS at 24 hours without hemorrhage, were compared between both arms using mixed logistic regression models adjusted for baseline characteristics. An interaction analysis between the EVT and MM arms for risk factors of UnEND was conducted. Results: Among 1723 patients assessable for UnEND, 160 patients experienced an UnEND (9.3%), including 9.1% (78/854) in the EVT arm and 9.4% (82/869) in the MM arm. There was no significant difference in the incidence of UnEND between the two study arms. In the EVT population, independent risk factors of UnEND were lower baseline NIHSS, higher baseline glucose, and lower collateral grade. In the MM population, the only independent predictor of UnEND was higher baseline glucose. However, we did not demonstrate an interaction between EVT and MM for baseline factors as risk factors of UnEND. UnEND was, similarly in both treatment groups, a significant predictor of unfavorable outcome in both the EVT (p<0.001) and MM (p<0.001) arms. Conclusions: UnEND is not an uncommon event, with a similar rate which ever treatment arm is considered. In the clinical scenario of AIS due to large vessel occlusion, no patient-related factor seems to increase the risk for UnEND when treated by EVT compared with MM.

Published
2023

2. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Author

Bakker, M.K., Spek, R.A.A. van der, Rheenen, W. van, Morel, S., Bourcier, R., Hostettler, I.C., Alg, V.S., Eijk, Kristel R. van, Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R.G., Lin, K., Li, L, Millwood, I.Y., Chen, Z., Rouleau, G.A., et al., Zhou, S., Rannikmäe, K., Sudlow, C.L., Houlden, H., Berg, L.H. van den, Dina, C., Naggara, O., Gentric, J.C., Shotar, E., Eugène, F., Desal, H., Winsvold, B.S., Børte, S., Johnsen, M.B., Brumpton, B.M., Sandvei, M.S., Willer, C.J., Hveem, K., Zwart, Jacob A., Verschuren, W.M., Friedrich, C.M., Hirsch, S., Schilling, S., Dauvillier, J., Martin, O., Jones, G.T., Bown, M.J., Ko, N.U., Kim, H., Coleman, J.R.I., Breen, G., Zaroff, J.G., Klijn, C.J.M., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Amouyel, P., Debette, S., Rinkel, G.J., Worrall, B.B., Pera, J., Slowik, A., Gaál-Paavola, E.I., Niemelä, M., Jääskeläinen, J.E., Fraunberg, M. von Und Zu, Lindgren, A., Broderick, J.P., Werring, D.J., Woo, D., Redon, R., Bijlenga, P., Kamatani, Y., Veldink, J.H., Ruigrok, Y.M., Bakker, M.K., Spek, R.A.A. van der, Rheenen, W. van, Morel, S., Bourcier, R., Hostettler, I.C., Alg, V.S., Eijk, Kristel R. van, Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R.G., Lin, K., Li, L, Millwood, I.Y., Chen, Z., Rouleau, G.A., et al., Zhou, S., Rannikmäe, K., Sudlow, C.L., Houlden, H., Berg, L.H. van den, Dina, C., Naggara, O., Gentric, J.C., Shotar, E., Eugène, F., Desal, H., Winsvold, B.S., Børte, S., Johnsen, M.B., Brumpton, B.M., Sandvei, M.S., Willer, C.J., Hveem, K., Zwart, Jacob A., Verschuren, W.M., Friedrich, C.M., Hirsch, S., Schilling, S., Dauvillier, J., Martin, O., Jones, G.T., Bown, M.J., Ko, N.U., Kim, H., Coleman, J.R.I., Breen, G., Zaroff, J.G., Klijn, C.J.M., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Amouyel, P., Debette, S., Rinkel, G.J., Worrall, B.B., Pera, J., Slowik, A., Gaál-Paavola, E.I., Niemelä, M., Jääskeläinen, J.E., Fraunberg, M. von Und Zu, Lindgren, A., Broderick, J.P., Werring, D.J., Woo, D., Redon, R., Bijlenga, P., Kamatani, Y., Veldink, J.H., and Ruigrok, Y.M.

Abstract

Contains fulltext : 229738.pdf (Publisher’s version ) (Closed access), Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

Published
2020

3. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Author

Bakker, M.K., Spek, R.A.A. van der, Rheenen, W. van, Morel, S., Bourcier, R., Hostettler, I.C., Alg, V.S., Eijk, Kristel R. van, Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R.G., Lin, K., Li, L, Millwood, I.Y., Chen, Z., Rouleau, G.A., et al., Zhou, S., Rannikmäe, K., Sudlow, C.L., Houlden, H., Berg, L.H. van den, Dina, C., Naggara, O., Gentric, J.C., Shotar, E., Eugène, F., Desal, H., Winsvold, B.S., Børte, S., Johnsen, M.B., Brumpton, B.M., Sandvei, M.S., Willer, C.J., Hveem, K., Zwart, Jacob A., Verschuren, W.M., Friedrich, C.M., Hirsch, S., Schilling, S., Dauvillier, J., Martin, O., Jones, G.T., Bown, M.J., Ko, N.U., Kim, H., Coleman, J.R.I., Breen, G., Zaroff, J.G., Klijn, C.J.M., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Amouyel, P., Debette, S., Rinkel, G.J., Worrall, B.B., Pera, J., Slowik, A., Gaál-Paavola, E.I., Niemelä, M., Jääskeläinen, J.E., Fraunberg, M. von Und Zu, Lindgren, A., Broderick, J.P., Werring, D.J., Woo, D., Redon, R., Bijlenga, P., Kamatani, Y., Veldink, J.H., Ruigrok, Y.M., Bakker, M.K., Spek, R.A.A. van der, Rheenen, W. van, Morel, S., Bourcier, R., Hostettler, I.C., Alg, V.S., Eijk, Kristel R. van, Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R.G., Lin, K., Li, L, Millwood, I.Y., Chen, Z., Rouleau, G.A., et al., Zhou, S., Rannikmäe, K., Sudlow, C.L., Houlden, H., Berg, L.H. van den, Dina, C., Naggara, O., Gentric, J.C., Shotar, E., Eugène, F., Desal, H., Winsvold, B.S., Børte, S., Johnsen, M.B., Brumpton, B.M., Sandvei, M.S., Willer, C.J., Hveem, K., Zwart, Jacob A., Verschuren, W.M., Friedrich, C.M., Hirsch, S., Schilling, S., Dauvillier, J., Martin, O., Jones, G.T., Bown, M.J., Ko, N.U., Kim, H., Coleman, J.R.I., Breen, G., Zaroff, J.G., Klijn, C.J.M., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Amouyel, P., Debette, S., Rinkel, G.J., Worrall, B.B., Pera, J., Slowik, A., Gaál-Paavola, E.I., Niemelä, M., Jääskeläinen, J.E., Fraunberg, M. von Und Zu, Lindgren, A., Broderick, J.P., Werring, D.J., Woo, D., Redon, R., Bijlenga, P., Kamatani, Y., Veldink, J.H., and Ruigrok, Y.M.

Abstract

Contains fulltext : 229738.pdf (Publisher’s version ) (Closed access), Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

Published
2020

4. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Author

Bakker, M.K., Spek, R.A.A. van der, Rheenen, W. van, Morel, S., Bourcier, R., Hostettler, I.C., Alg, V.S., Eijk, Kristel R. van, Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R.G., Lin, K., Li, L, Millwood, I.Y., Chen, Z., Rouleau, G.A., et al., Zhou, S., Rannikmäe, K., Sudlow, C.L., Houlden, H., Berg, L.H. van den, Dina, C., Naggara, O., Gentric, J.C., Shotar, E., Eugène, F., Desal, H., Winsvold, B.S., Børte, S., Johnsen, M.B., Brumpton, B.M., Sandvei, M.S., Willer, C.J., Hveem, K., Zwart, Jacob A., Verschuren, W.M., Friedrich, C.M., Hirsch, S., Schilling, S., Dauvillier, J., Martin, O., Jones, G.T., Bown, M.J., Ko, N.U., Kim, H., Coleman, J.R.I., Breen, G., Zaroff, J.G., Klijn, C.J.M., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Amouyel, P., Debette, S., Rinkel, G.J., Worrall, B.B., Pera, J., Slowik, A., Gaál-Paavola, E.I., Niemelä, M., Jääskeläinen, J.E., Fraunberg, M. von Und Zu, Lindgren, A., Broderick, J.P., Werring, D.J., Woo, D., Redon, R., Bijlenga, P., Kamatani, Y., Veldink, J.H., Ruigrok, Y.M., Bakker, M.K., Spek, R.A.A. van der, Rheenen, W. van, Morel, S., Bourcier, R., Hostettler, I.C., Alg, V.S., Eijk, Kristel R. van, Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R.G., Lin, K., Li, L, Millwood, I.Y., Chen, Z., Rouleau, G.A., et al., Zhou, S., Rannikmäe, K., Sudlow, C.L., Houlden, H., Berg, L.H. van den, Dina, C., Naggara, O., Gentric, J.C., Shotar, E., Eugène, F., Desal, H., Winsvold, B.S., Børte, S., Johnsen, M.B., Brumpton, B.M., Sandvei, M.S., Willer, C.J., Hveem, K., Zwart, Jacob A., Verschuren, W.M., Friedrich, C.M., Hirsch, S., Schilling, S., Dauvillier, J., Martin, O., Jones, G.T., Bown, M.J., Ko, N.U., Kim, H., Coleman, J.R.I., Breen, G., Zaroff, J.G., Klijn, C.J.M., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Amouyel, P., Debette, S., Rinkel, G.J., Worrall, B.B., Pera, J., Slowik, A., Gaál-Paavola, E.I., Niemelä, M., Jääskeläinen, J.E., Fraunberg, M. von Und Zu, Lindgren, A., Broderick, J.P., Werring, D.J., Woo, D., Redon, R., Bijlenga, P., Kamatani, Y., Veldink, J.H., and Ruigrok, Y.M.

Abstract

Contains fulltext : 229738.pdf (Publisher’s version ) (Closed access), Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

Published
2020

5. Imagerie par résonance magnétique de diffusion de l'encéphale chez l'adulte: Technique, résultats normaux et pathologiques

Author

UCL - (SLuc) Service de radiologie, Oppenheim, C., Naggara, O., Hamon, M., Gauvrit, J.-Y., Rodrigo, S., Bienvenu, M., Ménégon, P., Cosnard, Guy, Meder, J.-F., UCL - (SLuc) Service de radiologie, Oppenheim, C., Naggara, O., Hamon, M., Gauvrit, J.-Y., Rodrigo, S., Bienvenu, M., Ménégon, P., Cosnard, Guy, and Meder, J.-F.

Abstract

By probing microscopic molecular motions, diffusion-weighted imaging (DWI) is the only method available today that provides noninvasively information on molecular displacements over distances comparable to cell dimensions. Since it measures a parameter different from those assessed by conventional MRI, DWI represents a new imaging technique that goes beyond depiction of neuroanatomy and evaluates function and physiopathology. Image contrast is related to differences in the diffusion rate of water molecules rather than to changes in total tissue water. DWI has proven its high sensitivity in early detection of acute infarction; it is reliable in differentiating acute stroke from other diseases that mimic acute stroke in clinical terms and on conventional MR images. By differentiating lesions with decreased diffusion from those with increased diffusion, DWI is useful in the evaluation of a wide variety of other disease processes including neoplasms, demyelization, traumatic brain injury, intracranial infections. In particular, DWI can distinguish between epidermoid and arachnoid cysts and provides key information for the diagnosis of cerebral abscess. In some clinical situations, DWI data have a prognostic value. © 2005 Elsevier SAS. Tous droits réservés.

Published
2005

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