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MISW (Mitigation of space weather threats to GNSS services) is an EU/FP7 project with the purpose of tacklingthe research challenges associated with Space Weather effects on GNSS (Global Navigation Satellite System).In particular, the objective of MISW is to develop suitable algorithms capable of enabling Satellite BasedAugmentation Systems (e.g. EGNOS) in the low-latitude African sector. For this purpose, MISW has created adetailed picture of extreme space weather events that occurred in the past and in the current solar cycle. Despiteits weakness, the current solar cycle exhibited two superstorms that happened during the descending phase, inMarch and in June 2015. The latter has been studied in detail through a careful analysis of GNSS data acquiredby TEC (Total Electron Content) and scintillation monitors and by IGS and regional geodetic networks located inEurope and in Africa. The investigation enabled creating the actual scenarios of TEC gradients and scintillationthat occurred over a wide latitudinal extent between 21 and 30 June 2015. The investigation is based on calibratedTEC from different receivers, aiming at the estimation of east-west and north-south TEC gradients and on theintegration of calibrated TEC and TEC gradients with the scintillation data. The impact of the storm on GNSSperformance has also been investigated in terms of losses of lock.The results of this study highlight the importance of assessing the latitudinal and the longitudinal TEC gradientsas crucial information to identify to what extent different ionospheric sectors are severely affected by scintillation.On the other hand, this study also shows evidences of how TEC gradients are not always responsible for theobserved scintillation.Finally, the outcomes of the study demonstrate the complex relation between scintillation, TEC gradients andlosses of GNSS satellites lock.

Thesis (Sc. D.)--Harvard-MIT Division of Health Sciences and Technology, 2004., Includes bibliographical references (leaves 138-160)., Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and prompted investigation into the efficacy of PPAR agonists in parenchymal rejection (PR) and transplantation-associated arteriosclerosis (TxAA). Four different PPAR agonists (fenofibrate and Wy14643 for PPARα; BRL69453 and 15-deoxy-[delta]¹⁴Ì“¹⁶ Prostaglandin-J₂ for PPAR[gamma]) in an in vitro model of the alloresponse all demonstrated a robust and substantial attenuation of IFN[gamma], a cytokine that critically affects both rejection and TxAA. This occurred in a dose-dependent manner, independent of known IFN[gamma]-inducing cytokines. At the same times, PPAR activation increased the overall expression of chemokines but substantially decreased expression of two relevant chemokine receptors. Of the four agonists tested, fenofibrate, a largely PPARα-specific agonist, had the best profile of IFN[gamma] production to chemokine and chemokine receptor expression. At early time points after cardiac transplantation, fenofibrate administration showed findings consistent with those seen in vitro, including a tendency to reduce IFN[gamma]. However, long-term fenofibrate treatment significantly increased graft IFN[gamma] expression and inflammatory cell infiltration, thereby augmenting PR without ameliorating TxAA. Congenital deficiency of PPARα confirmed that the receptor plays a regulatory role in IFN[gamma] expression but is not necessary for graft infiltration by inflammatory cells. The findings constitute the first examination of the efficacy of PPAR agonists in, (cont.) solid-organ transplantation and suggest that in order to fully realize the beneficial anti-inflammatory effects of fenofibrate, additional strategies must be employed to inhibit graft inflammatory cell infiltration. Finally, a novel immunologic research tool based on the boron neutron capture reaction is proposed., by Emanuela Binello., Sc.D.

Thesis (Sc. D.)--Harvard-MIT Division of Health Sciences and Technology, 2004., Includes bibliographical references (leaves 138-160)., Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and prompted investigation into the efficacy of PPAR agonists in parenchymal rejection (PR) and transplantation-associated arteriosclerosis (TxAA). Four different PPAR agonists (fenofibrate and Wy14643 for PPARα; BRL69453 and 15-deoxy-[delta]¹⁴Ì“¹⁶ Prostaglandin-J₂ for PPAR[gamma]) in an in vitro model of the alloresponse all demonstrated a robust and substantial attenuation of IFN[gamma], a cytokine that critically affects both rejection and TxAA. This occurred in a dose-dependent manner, independent of known IFN[gamma]-inducing cytokines. At the same times, PPAR activation increased the overall expression of chemokines but substantially decreased expression of two relevant chemokine receptors. Of the four agonists tested, fenofibrate, a largely PPARα-specific agonist, had the best profile of IFN[gamma] production to chemokine and chemokine receptor expression. At early time points after cardiac transplantation, fenofibrate administration showed findings consistent with those seen in vitro, including a tendency to reduce IFN[gamma]. However, long-term fenofibrate treatment significantly increased graft IFN[gamma] expression and inflammatory cell infiltration, thereby augmenting PR without ameliorating TxAA. Congenital deficiency of PPARα confirmed that the receptor plays a regulatory role in IFN[gamma] expression but is not necessary for graft infiltration by inflammatory cells. The findings constitute the first examination of the efficacy of PPAR agonists in, (cont.) solid-organ transplantation and suggest that in order to fully realize the beneficial anti-inflammatory effects of fenofibrate, additional strategies must be employed to inhibit graft inflammatory cell infiltration. Finally, a novel immunologic research tool based on the boron neutron capture reaction is proposed., by Emanuela Binello., Sc.D.

A history of the world’s first democracy from its beginnings in Athens circa fifth century B.C. to its downfall 200 years later. The first democracy, established in ancient Greece more than 2,500 years ago, has served as the foundation for every democratic system of government instituted down the centuries. In this lively history, author Thomas N. Mitchell tells the full and remarkable story of how a radical new political order was born out of the revolutionary movements that swept through the Greek world in the seventh and sixth centuries B.C., how it took firm hold and evolved over the next two hundred years, and how it was eventually undone by the invading Macedonian conquerors, a superior military power. Mitchell’s history addresses the most crucial issues surrounding this first paradigm of democratic governance, including what initially inspired the political beliefs underpinning it, the ways the system succeeded and failed, how it enabled both an empire and a cultural revolution that transformed the world of arts and philosophy, and the nature of the Achilles heel that hastened the demise of Athenian democracy. “A clear, lively, and instructive account…. [Mitchell] has mastered the latest scholarship in the field and put it to good use in interpreting the ancient sources and demonstrating its character and importance in shaping democratic thought and institutions throughout the millennia.”—Donald Kagan, author of The Peloponnesian War “[Mitchell’s] close scholarship shines in documenting the transition of Athens from financially and morally bankrupt oligarchy to emancipated democracy 2,500 years ago…with a commendable attention to detail that beautifully captures the essence of ancient Greek culture and politics.”—Roslyn Fuller, Irish Times

A history of the world’s first democracy from its beginnings in Athens circa fifth century B.C. to its downfall 200 years later. The first democracy, established in ancient Greece more than 2,500 years ago, has served as the foundation for every democratic system of government instituted down the centuries. In this lively history, author Thomas N. Mitchell tells the full and remarkable story of how a radical new political order was born out of the revolutionary movements that swept through the Greek world in the seventh and sixth centuries B.C., how it took firm hold and evolved over the next two hundred years, and how it was eventually undone by the invading Macedonian conquerors, a superior military power. Mitchell’s history addresses the most crucial issues surrounding this first paradigm of democratic governance, including what initially inspired the political beliefs underpinning it, the ways the system succeeded and failed, how it enabled both an empire and a cultural revolution that transformed the world of arts and philosophy, and the nature of the Achilles heel that hastened the demise of Athenian democracy. “A clear, lively, and instructive account…. [Mitchell] has mastered the latest scholarship in the field and put it to good use in interpreting the ancient sources and demonstrating its character and importance in shaping democratic thought and institutions throughout the millennia.”—Donald Kagan, author of The Peloponnesian War “[Mitchell’s] close scholarship shines in documenting the transition of Athens from financially and morally bankrupt oligarchy to emancipated democracy 2,500 years ago…with a commendable attention to detail that beautifully captures the essence of ancient Greek culture and politics.”—Roslyn Fuller, Irish Times

A history of the world’s first democracy from its beginnings in Athens circa fifth century B.C. to its downfall 200 years later. The first democracy, established in ancient Greece more than 2,500 years ago, has served as the foundation for every democratic system of government instituted down the centuries. In this lively history, author Thomas N. Mitchell tells the full and remarkable story of how a radical new political order was born out of the revolutionary movements that swept through the Greek world in the seventh and sixth centuries B.C., how it took firm hold and evolved over the next two hundred years, and how it was eventually undone by the invading Macedonian conquerors, a superior military power. Mitchell’s history addresses the most crucial issues surrounding this first paradigm of democratic governance, including what initially inspired the political beliefs underpinning it, the ways the system succeeded and failed, how it enabled both an empire and a cultural revolution that transformed the world of arts and philosophy, and the nature of the Achilles heel that hastened the demise of Athenian democracy. “A clear, lively, and instructive account…. [Mitchell] has mastered the latest scholarship in the field and put it to good use in interpreting the ancient sources and demonstrating its character and importance in shaping democratic thought and institutions throughout the millennia.”—Donald Kagan, author of The Peloponnesian War “[Mitchell’s] close scholarship shines in documenting the transition of Athens from financially and morally bankrupt oligarchy to emancipated democracy 2,500 years ago…with a commendable attention to detail that beautifully captures the essence of ancient Greek culture and politics.”—Roslyn Fuller, Irish Times

A history of the world’s first democracy from its beginnings in Athens circa fifth century B.C. to its downfall 200 years later. The first democracy, established in ancient Greece more than 2,500 years ago, has served as the foundation for every democratic system of government instituted down the centuries. In this lively history, author Thomas N. Mitchell tells the full and remarkable story of how a radical new political order was born out of the revolutionary movements that swept through the Greek world in the seventh and sixth centuries B.C., how it took firm hold and evolved over the next two hundred years, and how it was eventually undone by the invading Macedonian conquerors, a superior military power. Mitchell’s history addresses the most crucial issues surrounding this first paradigm of democratic governance, including what initially inspired the political beliefs underpinning it, the ways the system succeeded and failed, how it enabled both an empire and a cultural revolution that transformed the world of arts and philosophy, and the nature of the Achilles heel that hastened the demise of Athenian democracy. “A clear, lively, and instructive account…. [Mitchell] has mastered the latest scholarship in the field and put it to good use in interpreting the ancient sources and demonstrating its character and importance in shaping democratic thought and institutions throughout the millennia.”—Donald Kagan, author of The Peloponnesian War “[Mitchell’s] close scholarship shines in documenting the transition of Athens from financially and morally bankrupt oligarchy to emancipated democracy 2,500 years ago…with a commendable attention to detail that beautifully captures the essence of ancient Greek culture and politics.”—Roslyn Fuller, Irish Times

strophic with chorus, piano and voice (solo and satb chorus), To My Friend, Frank T. Martin, ads on inside front cover for J.L. Peters stock, 10183-3, Johns Hopkins University, Levy Sheet Music Collection, Box 105, Item 061, Words by S.N. Mitchell. Music by J.C. Chamberlain., Snyder & Black, 92 William St. N.Y.

Papers, Addresses, Reports: Let the Chips Fall Where They May; The Fish Population of a Spring-fed Stream System in Southern Illinois; Fishing Pressure and Fishing Success at Argyle Lake, McDonough County, Illinois, as Indicated by Creel Census; Flotation of Fishes Following Stunning by Electrical Shock; Fishery Values of a Restored Illinois River Bottomland Lake; Literature Pertaining to Formation of Acid-mine Wastes and Their Effects on the Chemistry and Fauna of Streams; The Effects of Drought Conditions on the Fish and Bottom Organisms of Two Small Oxbow Ponds; University of Illinois Herbarium, Its History and Development Since 1868; Plant Fossils from Mankato Terrace Along Hutchins Creek, Union County, Illinois; Notes on the Ecology of American Lotus in Southern Illinois; Growth and Yield of Sinnissippi Forest Stands; The Ravine Flora of Winnebago County, Illinois; Modification of Zein by Deamidation; Absorption of Oxygen by Blood Plasma Fractions in Alkaline Media; The Effect of Isoniazid on the Immunity Produced by Vaccination of Guinea Pigs with BCG; Study of a Blood Polarographic Change Associated with Walker Tumor Growth; Stearic Hindrance Effects of the Tertiary Butyl Radical in Some Mannich Condensations; Effects of Feeding Baby Pigs a Diet Deficient in Sodium; Saving Water in Reservoirs; Teaching of Conservation of Natural Resources in Illinois Colleges and Universities: A Re-Appraisal; Forecasting Explosion conditions in Coal Mines; The Changing Petroleum Industry of Western Europe; Kenya, East Africa: An Aspect of Population Geography ; A Land-Use Map from Census Data-Parana, Brazil, as an Example; Large Scale Commercial Beef Cattle Feeding in Northern Illinois; Uses and Limitations of Electrical Prospecting for Water Supplies; Electric-Log Cross-Sections of the Silurian-Devonian Formations of a Part of Central Illinois; Source and Occurrence of Brines for Waterflooding in Illinois; Age and Stratigraphic Relationship of the Caloosahatchee Ma