Author: "Mertz, D." / Publication Type: Electronic Resources - Searchworks@Jio Institute Digital Library Search Results

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55 results on '"Mertz, D."'

1. Trends in Clostridioides difficile infection rates in Canadian hospitals during the coronavirus disease 2019 (COVID-19) pandemic

Author: Choi, KB, Du, T, Silva, A, Golding, GR, Pelude, L, Mitchell, R, Rudnick, W, Hizon, R, Al-Rawahi, GN, Chow, B, Davis, I, Evans, GA, Frenette, C, Johnstone, J, Kibsey, P, Katz, KC, Langley, JM, Lee, BE, Longtin, Y, Mertz, D, Minion, J, Science, M, Srigley, JA, Stagg, P, Suh, KN, Thampi, N, Wong, A, Comeau, JL, Hota, SS, Choi, KB, Du, T, Silva, A, Golding, GR, Pelude, L, Mitchell, R, Rudnick, W, Hizon, R, Al-Rawahi, GN, Chow, B, Davis, I, Evans, GA, Frenette, C, Johnstone, J, Kibsey, P, Katz, KC, Langley, JM, Lee, BE, Longtin, Y, Mertz, D, Minion, J, Science, M, Srigley, JA, Stagg, P, Suh, KN, Thampi, N, Wong, A, Comeau, JL, and Hota, SS
Abstract: The coronavirus disease 2019 (COVID-19) pandemic has placed significant burden on healthcare systems. We compared Clostridioides difficile infection (CDI) epidemiology before and during the pandemic across 71 hospitals participating in the Canadian Nosocomial Infection Surveillance Program. Using an interrupted time series analysis, we showed that CDI rates significantly increased during the COVID-19 pandemic.
Published: 2023

2. Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015-2019

Author: Du, T, Choi, KB, Silva, A, Golding, GR, Pelude, L, Hizon, R, Al-Rawahi, GN, Brooks, J, Chow, B, Collet, JC, Comeau, JL, Davis, I, Evans, GA, Frenette, C, Han, G, Johnstone, J, Kibsey, P, Katz, KC, Langley, JM, Lee, BE, Longtin, Y, Mertz, D, Minion, J, Science, M, Srigley, JA, Stagg, P, Suh, KN, Thampi, N, Wong, A, Hota, SS, Du, T, Choi, KB, Silva, A, Golding, GR, Pelude, L, Hizon, R, Al-Rawahi, GN, Brooks, J, Chow, B, Collet, JC, Comeau, JL, Davis, I, Evans, GA, Frenette, C, Han, G, Johnstone, J, Kibsey, P, Katz, KC, Langley, JM, Lee, BE, Longtin, Y, Mertz, D, Minion, J, Science, M, Srigley, JA, Stagg, P, Suh, KN, Thampi, N, Wong, A, and Hota, SS
Abstract: We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015-2019. The study encompassed 18,455 CDI cases, 13,735 (74.4%) HA and 4,720 (25.6%) CA. During 2015-2019, HA CDI rates decreased by 23.8%, whereas CA decreased by 18.8%. HA CDI was significantly associated with increased 30-day all-cause mortality as compared with CA CDI (p<0.01). Of 2,506 isolates analyzed, the most common ribotypes (RTs) were RT027, RT106, RT014, and RT020. RT027 was more often associated with CDI-attributable death than was non-RT027, regardless of acquisition type. Overall resistance C. difficile rates were similar for all drugs tested except moxifloxacin. Adult HA and CA CDI rates have declined, coinciding with changes in prevalence of RT027 and RT106. Infection prevention and control and continued national surveillance are integral to clarifying CDI epidemiology, investigation, and control.
Published: 2022

3. Development of a tool to assess evidence for causality in studies implicating sink drains as a reservoir for hospital-acquired gammaproteobacterial infection.

Author: Coleman B.L., Stuart R., Jamal A.J., Kandel C., Ahangari N., McGeer A., Volling C., Thomas S., Johnstone J., Maltezou H.C., Mertz D., Coleman B.L., Stuart R., Jamal A.J., Kandel C., Ahangari N., McGeer A., Volling C., Thomas S., Johnstone J., Maltezou H.C., and Mertz D.
Abstract: Background: Decades of studies document an association between Gammaproteobacteria in sink drains and hospital-acquired infections, but the evidence for causality is unclear. Aim(s): We aimed to develop a tool to assess the quality of evidence for causality in research studies that implicate sink drains as reservoirs for hospital-acquired Gammaproteobacterial infections. Method(s): We used a modified Delphi process with recruited experts in hospital epidemiology to develop this tool from a pre-existing causal assessment application. Finding(s): Through four rounds of feedback and revision we developed the 'Modified CADDIS Tool for Causality Assessment of Sink Drains as a Reservoir for Hospital-Acquired Gammaproteobacterial Infection or Colonization'. In tests of tool application to published literature during development, mean percent agreement ranged from 46.7% to 87.5%, and the Gwet's AC1 statistic (adjusting for chance agreement) ranged from 0.13 to 1.0 (median 68.1). Areas of disagreement were felt to result from lack of a priori knowledge of causal pathways from sink drains to patients and uncertain influence of co-interventions to prevent organism acquisition. Modifications were made until consensus was achieved that further iterations would not improve the tool. When the tool was applied to 44 articles by two independent reviewers in an ongoing systematic review, percent agreement ranged from 93% to 98%, and the Gwet's AC1 statistic was 0.91-0.97. Conclusion(s): The modified causality tool was useful for evaluating studies that implicate sink drains as reservoirs for hospital-acquired infections and may help guide the conduct and reporting of future research.Copyright © 2020 The Healthcare Infection Society
Published: 2021

4. Are Sink Drainage Systems a Reservoir for Hospital-Acquired Gammaproteobacteria Colonization and Infection? A Systematic Review.

Author: Volling C., Ahangari N., Bartoszko J.J., Coleman B.L., Garcia-Jeldes F., Jamal A.J., Johnstone J., Kandel C., Kohler P., Maltezou H.C., Maze Dit Mieusement L., Mckenzie N., Mertz D., Monod A., Saeed S., Shea B., Stuart R.L., Thomas S., Uleryk E., Mcgeer A., Volling C., Ahangari N., Bartoszko J.J., Coleman B.L., Garcia-Jeldes F., Jamal A.J., Johnstone J., Kandel C., Kohler P., Maltezou H.C., Maze Dit Mieusement L., Mckenzie N., Mertz D., Monod A., Saeed S., Shea B., Stuart R.L., Thomas S., Uleryk E., and Mcgeer A.
Abstract: Increasing rates of antimicrobial-resistant organisms have focused attention on sink drainage systems as reservoirs for hospital-acquired Gammaproteobacteria colonization and infection. We aimed to assess the quality of evidence for transmission from this reservoir. We searched 8 databases and identified 52 studies implicating sink drainage systems in acute care hospitals as a reservoir for Gammaproteobacterial colonization/infection. We used a causality tool to summarize the quality of evidence. Included studies provided evidence of co-occurrence of contaminated sink drainage systems and colonization/infection, temporal sequencing compatible with sink drainage reservoirs, some steps in potential causal pathways, and relatedness between bacteria from sink drainage systems and patients. Some studies provided convincing evidence of reduced risk of organism acquisition following interventions. No single study provided convincing evidence across all causality domains, and the attributable fraction of infections related to sink drainage systems remains unknown. These results may help to guide conduct and reporting in future studies.Copyright © 2020 The Author(s).
Published: 2021

5. Development of a tool to assess evidence for causality in studies implicating sink drains as a reservoir for hospital-acquired gammaproteobacterial infection.

Author: Coleman B.L., Stuart R., Jamal A.J., Kandel C., Ahangari N., McGeer A., Volling C., Thomas S., Johnstone J., Maltezou H.C., Mertz D., Coleman B.L., Stuart R., Jamal A.J., Kandel C., Ahangari N., McGeer A., Volling C., Thomas S., Johnstone J., Maltezou H.C., and Mertz D.
Abstract: Background: Decades of studies document an association between Gammaproteobacteria in sink drains and hospital-acquired infections, but the evidence for causality is unclear. Aim(s): We aimed to develop a tool to assess the quality of evidence for causality in research studies that implicate sink drains as reservoirs for hospital-acquired Gammaproteobacterial infections. Method(s): We used a modified Delphi process with recruited experts in hospital epidemiology to develop this tool from a pre-existing causal assessment application. Finding(s): Through four rounds of feedback and revision we developed the 'Modified CADDIS Tool for Causality Assessment of Sink Drains as a Reservoir for Hospital-Acquired Gammaproteobacterial Infection or Colonization'. In tests of tool application to published literature during development, mean percent agreement ranged from 46.7% to 87.5%, and the Gwet's AC1 statistic (adjusting for chance agreement) ranged from 0.13 to 1.0 (median 68.1). Areas of disagreement were felt to result from lack of a priori knowledge of causal pathways from sink drains to patients and uncertain influence of co-interventions to prevent organism acquisition. Modifications were made until consensus was achieved that further iterations would not improve the tool. When the tool was applied to 44 articles by two independent reviewers in an ongoing systematic review, percent agreement ranged from 93% to 98%, and the Gwet's AC1 statistic was 0.91-0.97. Conclusion(s): The modified causality tool was useful for evaluating studies that implicate sink drains as reservoirs for hospital-acquired infections and may help guide the conduct and reporting of future research.Copyright © 2020 The Healthcare Infection Society
Published: 2021

6. Are Sink Drainage Systems a Reservoir for Hospital-Acquired Gammaproteobacteria Colonization and Infection? A Systematic Review.

Author: Volling C., Ahangari N., Bartoszko J.J., Coleman B.L., Garcia-Jeldes F., Jamal A.J., Johnstone J., Kandel C., Kohler P., Maltezou H.C., Maze Dit Mieusement L., Mckenzie N., Mertz D., Monod A., Saeed S., Shea B., Stuart R.L., Thomas S., Uleryk E., Mcgeer A., Volling C., Ahangari N., Bartoszko J.J., Coleman B.L., Garcia-Jeldes F., Jamal A.J., Johnstone J., Kandel C., Kohler P., Maltezou H.C., Maze Dit Mieusement L., Mckenzie N., Mertz D., Monod A., Saeed S., Shea B., Stuart R.L., Thomas S., Uleryk E., and Mcgeer A.
Abstract: Increasing rates of antimicrobial-resistant organisms have focused attention on sink drainage systems as reservoirs for hospital-acquired Gammaproteobacteria colonization and infection. We aimed to assess the quality of evidence for transmission from this reservoir. We searched 8 databases and identified 52 studies implicating sink drainage systems in acute care hospitals as a reservoir for Gammaproteobacterial colonization/infection. We used a causality tool to summarize the quality of evidence. Included studies provided evidence of co-occurrence of contaminated sink drainage systems and colonization/infection, temporal sequencing compatible with sink drainage reservoirs, some steps in potential causal pathways, and relatedness between bacteria from sink drainage systems and patients. Some studies provided convincing evidence of reduced risk of organism acquisition following interventions. No single study provided convincing evidence across all causality domains, and the attributable fraction of infections related to sink drainage systems remains unknown. These results may help to guide conduct and reporting in future studies.Copyright © 2020 The Author(s).
Published: 2021

7. Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Author: Cotin G., Blanco-Andujar C., Perton F., Asín L., De La Fuente J.M., Reichardt W., Schaffner D., Ngyen D.-V., Mertz D., Kiefer C., Meyer F., Spassov S., Ersen O., Chatzidakis M., Botton G.A., Hénoumont C., Laurent S., Greneche J.-M., Terán, Francisco, Ortega D., Felder-Flesch D., Begin-Colin S., Cotin G., Blanco-Andujar C., Perton F., Asín L., De La Fuente J.M., Reichardt W., Schaffner D., Ngyen D.-V., Mertz D., Kiefer C., Meyer F., Spassov S., Ersen O., Chatzidakis M., Botton G.A., Hénoumont C., Laurent S., Greneche J.-M., Terán, Francisco, Ortega D., Felder-Flesch D., and Begin-Colin S.
Published: 2021

8. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author: Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Ingen, J. van, Halbe, M., Perkins, K.M., Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Ingen, J. van, Halbe, M., and Perkins, K.M.
Abstract: Contains fulltext : 216662.pdf (Publisher’s version ) (Open Access)
Published: 2020

9. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.

Author: Sander P., Chu V.H., Durack D.T., Fortes C.Q., Fowler V., Krachmer A.W., Wilson W.R., Stewart R., Herwaldt L.A., Widmer A., Brown Elliot B.A., Falk V., Halbe M., Scriven J.E., Sax H., van Ingen J., Mestres C.A., Diekema D., Brown-Elliott B.A., Wallace R.J., Baddour L.M., Miro J.M., Hoen B., Athan E., Bayer A., Barsic B., Stuart R.L., Hasse B., Hannan M.M., Keller P.M., Maurer F.P., Sommerstein R., Mertz D., Wagner D., Fernandez-Hidalgo N., Nomura J., Manfrin V., Bettex D., Hernandez Conte A., Durante-Mangoni E., Tang T.H.-C., Lundgren J., Gordon S., Jarashow M.C., Schreiber P.W., Niemann S., Kohl T.A., Daley C.L., Stewardson A.J., Whitener C.J., Perkins K., Plachouras D., Lamagni T., Chand M., Freiberger T., Zweifel S., Corey G.R., Schulthess B., Sander P., Chu V.H., Durack D.T., Fortes C.Q., Fowler V., Krachmer A.W., Wilson W.R., Stewart R., Herwaldt L.A., Widmer A., Brown Elliot B.A., Falk V., Halbe M., Scriven J.E., Sax H., van Ingen J., Mestres C.A., Diekema D., Brown-Elliott B.A., Wallace R.J., Baddour L.M., Miro J.M., Hoen B., Athan E., Bayer A., Barsic B., Stuart R.L., Hasse B., Hannan M.M., Keller P.M., Maurer F.P., Sommerstein R., Mertz D., Wagner D., Fernandez-Hidalgo N., Nomura J., Manfrin V., Bettex D., Hernandez Conte A., Durante-Mangoni E., Tang T.H.-C., Lundgren J., Gordon S., Jarashow M.C., Schreiber P.W., Niemann S., Kohl T.A., Daley C.L., Stewardson A.J., Whitener C.J., Perkins K., Plachouras D., Lamagni T., Chand M., Freiberger T., Zweifel S., Corey G.R., and Schulthess B.
Abstract: Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.Copyright © 2019 The Author(s)
Published: 2020

10. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.

Author: Sander P., Chu V.H., Durack D.T., Fortes C.Q., Fowler V., Krachmer A.W., Wilson W.R., Stewart R., Herwaldt L.A., Widmer A., Brown Elliot B.A., Falk V., Halbe M., Scriven J.E., Sax H., van Ingen J., Mestres C.A., Diekema D., Brown-Elliott B.A., Wallace R.J., Baddour L.M., Miro J.M., Hoen B., Athan E., Bayer A., Barsic B., Stuart R.L., Hasse B., Hannan M.M., Keller P.M., Maurer F.P., Sommerstein R., Mertz D., Wagner D., Fernandez-Hidalgo N., Nomura J., Manfrin V., Bettex D., Hernandez Conte A., Durante-Mangoni E., Tang T.H.-C., Lundgren J., Gordon S., Jarashow M.C., Schreiber P.W., Niemann S., Kohl T.A., Daley C.L., Stewardson A.J., Whitener C.J., Perkins K., Plachouras D., Lamagni T., Chand M., Freiberger T., Zweifel S., Corey G.R., Schulthess B., Sander P., Chu V.H., Durack D.T., Fortes C.Q., Fowler V., Krachmer A.W., Wilson W.R., Stewart R., Herwaldt L.A., Widmer A., Brown Elliot B.A., Falk V., Halbe M., Scriven J.E., Sax H., van Ingen J., Mestres C.A., Diekema D., Brown-Elliott B.A., Wallace R.J., Baddour L.M., Miro J.M., Hoen B., Athan E., Bayer A., Barsic B., Stuart R.L., Hasse B., Hannan M.M., Keller P.M., Maurer F.P., Sommerstein R., Mertz D., Wagner D., Fernandez-Hidalgo N., Nomura J., Manfrin V., Bettex D., Hernandez Conte A., Durante-Mangoni E., Tang T.H.-C., Lundgren J., Gordon S., Jarashow M.C., Schreiber P.W., Niemann S., Kohl T.A., Daley C.L., Stewardson A.J., Whitener C.J., Perkins K., Plachouras D., Lamagni T., Chand M., Freiberger T., Zweifel S., Corey G.R., and Schulthess B.
Abstract: Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.Copyright © 2019 The Author(s)
Published: 2020

11. International Society of Cardiovascular Infectious Diseases Guidelines for the diagnosis, treatment and prevention of disseminated Mycobacterium chimaera infection following cardiac surgery with cardiopulmonary bypass

Author: Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T.H.C., Stuart, R.L., Lundgren, J., Gordon, S., Jarashow, M.C., Schreiber, P.W., Athan, Eugene, Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T.H.C., Stuart, R.L., Lundgren, J., Gordon, S., Jarashow, M.C., Schreiber, P.W., and Athan, Eugene
Published: 2020

12. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author: Hasse, B, Hannan, MM, Keller, PM, Maurer, FP, Sommerstein, R, Mertz, D, Wagner, D, Fernandez-Hidalgo, N, Nomura, J, Manfrin, V, Bettex, D, Conte, AH, Durante-Mangoni, E, Tang, TH-C, Stuart, RL, Lundgren, J, Gordon, S, Jarashow, MC, Schreiber, PW, Niemann, S, Kohl, TA, Daley, CL, Stewardson, AJ, Whitener, CJ, Perkins, K, Plachouras, D, Lamagni, T, Chand, M, Freiberger, T, Zweifel, S, Sander, P, Schulthess, B, Scriven, JE, Sax, H, van Ingen, J, Mestres, CA, Diekema, D, Brown-Elliott, BA, Wallace, RJ, Baddour, LM, Miro, JM, Hoen, B, Athan, E, Bayer, A, Barsic, B, Corey, GR, Chu, VH, Durack, DT, Querido Fortes, C, Fowler, V, Krachmer, AW, Durante-Magnoni, E, Miro, M, Wilson, WR, Striven, J, Stewart, R, Herwaldt, LA, Schreiber, P, Stewardson, A, Widmer, A, Elliot, BAB, Daley, C, Keller, P, Maurer, F, Falk, V, Halbe, M, Perkins, KM, Hasse, B, Hannan, MM, Keller, PM, Maurer, FP, Sommerstein, R, Mertz, D, Wagner, D, Fernandez-Hidalgo, N, Nomura, J, Manfrin, V, Bettex, D, Conte, AH, Durante-Mangoni, E, Tang, TH-C, Stuart, RL, Lundgren, J, Gordon, S, Jarashow, MC, Schreiber, PW, Niemann, S, Kohl, TA, Daley, CL, Stewardson, AJ, Whitener, CJ, Perkins, K, Plachouras, D, Lamagni, T, Chand, M, Freiberger, T, Zweifel, S, Sander, P, Schulthess, B, Scriven, JE, Sax, H, van Ingen, J, Mestres, CA, Diekema, D, Brown-Elliott, BA, Wallace, RJ, Baddour, LM, Miro, JM, Hoen, B, Athan, E, Bayer, A, Barsic, B, Corey, GR, Chu, VH, Durack, DT, Querido Fortes, C, Fowler, V, Krachmer, AW, Durante-Magnoni, E, Miro, M, Wilson, WR, Striven, J, Stewart, R, Herwaldt, LA, Schreiber, P, Stewardson, A, Widmer, A, Elliot, BAB, Daley, C, Keller, P, Maurer, F, Falk, V, Halbe, M, and Perkins, KM
Abstract: Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.
Published: 2020

13. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author: Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Ingen, J. van, Halbe, M., Perkins, K.M., Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Ingen, J. van, Halbe, M., and Perkins, K.M.
Abstract: Contains fulltext : 216662.pdf (Publisher’s version ) (Open Access)
Published: 2020

14. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author: Hasse, B., Hannan, M. M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T. H.C., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C. L., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J. E., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., Hoen, B., Hasse, B., Hannan, M. M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T. H.C., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C. L., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J. E., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., and Hoen, B.
Abstract: Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.
Published: 2020

15. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author: Hasse, B., Hannan, M. M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T. H.C., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C. L., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J. E., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., Hoen, B., Hasse, B., Hannan, M. M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T. H.C., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C. L., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J. E., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., and Hoen, B.
Abstract: Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.
Published: 2020

16. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author: Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli M., Kluger Y., Ansaloni L., Carlet J., Brink A., Hardcastle T. C., Khanna A., Chicom-Mefire A., Rodriguez-Bano J., Nathwani D., Mendelson M., Watkins R. R., Pulcini C., Beovic B., May A. K., Itani K. M. F., Mazuski J. E., Fry D. E., Coccolini F., Rasxa K., Montravers P., Eckmann C., Abbo L. M., Abubakar S., Abu-Zidan F. M., Adesunkanmi A. K., Al-Hasan M. N., Althani A. A., Ticas J. E. A., Ansari S., Ansumana R., Da Silva A. R. A., Augustin G., Bala M., Balogh Z. J., Baraket O., Bassetti M., Bellanova G., Beltran M. A., Ben-Ishay O., Biffl W. L., Boermeester M. A., Brecher S. M., Bueno J., Cainzos M. A., Cairns K., Camacho-Ortiz A., Ceresoli M., Chandy S. J., Cherry-Bukowiec J. R., Cirocchi R., Colak E., Corcione A., Cornely O. A., Cortese F., Cui Y., Curcio D., Damaskos D., Dasx K., Delibegovic S., Demetrashvili Z., De Simone B., De Souza H. P., De Waele J., Dhingra S., Diaz J. J., Di Carlo I., Di Marzo F., Di Saverio S., Dogjani A., Dorj G., Dortet L., Duane T. M., Dupont H., Egiev V. N., Eid H. O., Elmangory M., El-Sayed Marei H., Enani M. A., Escandon-Vargas K., Faro M. P., Ferrada P., Foghetti D., Foianini E., Fraga G. P., Frattima S., Gandhi C., Gattuso G., Giamarellou E., Ghnnam W., Gkiokas G., Girardis M., Goff D. A., Gomes C. A., Gomi H., Gronerth R. I. G., Guirao X., Guzman-Blanco M., Haque M., Hecker A., Hell M., Herzog T., Hicks L., Kafka-Ritsch R., Kao L. S., Kanj S. S., Kaplan L. J., Kapoor G., Karamarkovic A., Kashuk J., Kenig J., Khamis F., Khokha V., Kiguba R., Kirkpatrick A. W., Korner H., Koike K., Kok K. Y. Y., Kon K., Kong V., Inaba K., Ioannidis O., Isik A., Iskandar K., Labbate M., Labricciosa F. M., Lagrou K., Lagunes L., Latifi R., Lasithiotakis K., Laxminarayan R., Lee J. G., Leone M., Leppaniemi A., Li Y., Liang S. Y., Liau K. -H., Litvin A., Loho T., Lowman W., Machain G. M., Maier R. V., Manzano-Nunez R., Marinis A., Marmorale C., Martin-Loeches I., Marwah S., Maseda E., McFarlane M., De Melo R. B., Melotti M. R., Memish Z., Mertz D., Mesina C., Menichetti F., Mishra S. K., Montori G., Moore E. E., Moore F. A., Naidoo N., Napolitano L., Negoi I., Nicolau D. P., Nikolopoulos I., Nord C. E., Ofori-Asenso R., Olaoye I., Omari A. H., Ordonez C. A., Ouadii M., Ouedraogo A. -S., Pagani L., Paiva J. A., Parreira J. G., Pata F., Pereira J., Pereira N. R., Petrosillo N., Picetti E., Pintar T., Ponce-De-Leon A., Popovski Z., Poulakou G., Preller J., Guerrero A. P., Pupelis G., Quiodettis M., Rawson T. M., Reichert M., Reinhart K., Rems M., Rello J., Rizoli S., Roberts J., Rubio-Perez I., Ruppe E., Sakakushev B., Sall I., Kafil H. S., Sanders J., Sato N., Sawyer R. G., Scalea T., Scibe R., Scudeller L., Lohse H. S., Sganga G., Shafiq N., Shah J. N., Spigaglia P., Suroowan S., Tsioutis C., Sifri C. D., Siribumrungwong B., Sugrue M., Talving P., Tan B. K., Tarasconi A., Tascini C., Tilsed J., Timsit J. -F., Tumbarello M., Trung N. T., Ulrych J., Uranues S., Velmahos G., Vereczkei A. G., Viale P., Estape J. V., Viscoli C., Wagenlehner F., Wright B. J., Xiao Y., Yuan K. -C., Zachariah S. K., Zahar J. R., Mergulhao P., Catena F., Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli M., Kluger Y., Ansaloni L., Carlet J., Brink A., Hardcastle T. C., Khanna A., Chicom-Mefire A., Rodriguez-Bano J., Nathwani D., Mendelson M., Watkins R. R., Pulcini C., Beovic B., May A. K., Itani K. M. F., Mazuski J. E., Fry D. E., Coccolini F., Rasxa K., Montravers P., Eckmann C., Abbo L. M., Abubakar S., Abu-Zidan F. M., Adesunkanmi A. K., Al-Hasan M. N., Althani A. A., Ticas J. E. A., Ansari S., Ansumana R., Da Silva A. R. A., Augustin G., Bala M., Balogh Z. J., Baraket O., Bassetti M., Bellanova G., Beltran M. A., Ben-Ishay O., Biffl W. L., Boermeester M. A., Brecher S. M., Bueno J., Cainzos M. A., Cairns K., Camacho-Ortiz A., Ceresoli M., Chandy S. J., Cherry-Bukowiec J. R., Cirocchi R., Colak E., Corcione A., Cornely O. A., Cortese F., Cui Y., Curcio D., Damaskos D., Dasx K., Delibegovic S., Demetrashvili Z., De Simone B., De Souza H. P., De Waele J., Dhingra S., Diaz J. J., Di Carlo I., Di Marzo F., Di Saverio S., Dogjani A., Dorj G., Dortet L., Duane T. M., Dupont H., Egiev V. N., Eid H. O., Elmangory M., El-Sayed Marei H., Enani M. A., Escandon-Vargas K., Faro M. P., Ferrada P., Foghetti D., Foianini E., Fraga G. P., Frattima S., Gandhi C., Gattuso G., Giamarellou E., Ghnnam W., Gkiokas G., Girardis M., Goff D. A., Gomes C. A., Gomi H., Gronerth R. I. G., Guirao X., Guzman-Blanco M., Haque M., Hecker A., Hell M., Herzog T., Hicks L., Kafka-Ritsch R., Kao L. S., Kanj S. S., Kaplan L. J., Kapoor G., Karamarkovic A., Kashuk J., Kenig J., Khamis F., Khokha V., Kiguba R., Kirkpatrick A. W., Korner H., Koike K., Kok K. Y. Y., Kon K., Kong V., Inaba K., Ioannidis O., Isik A., Iskandar K., Labbate M., Labricciosa F. M., Lagrou K., Lagunes L., Latifi R., Lasithiotakis K., Laxminarayan R., Lee J. G., Leone M., Leppaniemi A., Li Y., Liang S. Y., Liau K. -H., Litvin A., Loho T., Lowman W., Machain G. M., Maier R. V., Manzano-Nunez R., Marinis A., Marmorale C., Martin-Loeches I., Marwah S., Maseda E., McFarlane M., De Melo R. B., Melotti M. R., Memish Z., Mertz D., Mesina C., Menichetti F., Mishra S. K., Montori G., Moore E. E., Moore F. A., Naidoo N., Napolitano L., Negoi I., Nicolau D. P., Nikolopoulos I., Nord C. E., Ofori-Asenso R., Olaoye I., Omari A. H., Ordonez C. A., Ouadii M., Ouedraogo A. -S., Pagani L., Paiva J. A., Parreira J. G., Pata F., Pereira J., Pereira N. R., Petrosillo N., Picetti E., Pintar T., Ponce-De-Leon A., Popovski Z., Poulakou G., Preller J., Guerrero A. P., Pupelis G., Quiodettis M., Rawson T. M., Reichert M., Reinhart K., Rems M., Rello J., Rizoli S., Roberts J., Rubio-Perez I., Ruppe E., Sakakushev B., Sall I., Kafil H. S., Sanders J., Sato N., Sawyer R. G., Scalea T., Scibe R., Scudeller L., Lohse H. S., Sganga G., Shafiq N., Shah J. N., Spigaglia P., Suroowan S., Tsioutis C., Sifri C. D., Siribumrungwong B., Sugrue M., Talving P., Tan B. K., Tarasconi A., Tascini C., Tilsed J., Timsit J. -F., Tumbarello M., Trung N. T., Ulrych J., Uranues S., Velmahos G., Vereczkei A. G., Viale P., Estape J. V., Viscoli C., Wagenlehner F., Wright B. J., Xiao Y., Yuan K. -C., Zachariah S. K., Zahar J. R., Mergulhao P., and Catena F.
Abstract: This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.
Published: 2017

17. Probiotics to prevent Clostridium difficile infection in patients receiving antibiotics

Author: Goldenberg, JZ, Mertz, D, Johnston, BC, Goldenberg, JZ, Mertz, D, and Johnston, BC
Abstract: © 2018 American Medical Association. All rights reserved. CLINICAL QUESTION In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? BOTTOM LINE Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low–quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.
Published: 2018

18. Probiotics to prevent Clostridium difficile infection in patients receiving antibiotics

Author: Goldenberg, JZ, Mertz, D, Johnston, BC, Goldenberg, JZ, Mertz, D, and Johnston, BC
Abstract: © 2018 American Medical Association. All rights reserved. CLINICAL QUESTION In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? BOTTOM LINE Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low–quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.
Published: 2018

19. Eradication of an epidemic methicillin-resistant Staphylococcus aureus (MRSA) from a geriatric university hospital: evidence from a 10-year follow-up

Author: Mertz, D., Frei, R., Periat, N., Scheidegger, C., Battegay, M., Seiler, W., Widmer, A., Mertz, D., Frei, R., Periat, N., Scheidegger, C., Battegay, M., Seiler, W., and Widmer, A.
Abstract: We report on a successful eradication of methicillin-resistant S. aureus (MRSA) after an epidemic in 1992 in the geriatric ward of a tertiary-care hospital. After identification of MRSA in seven patients, all patients and staff members in the geriatric ward underwent screening. A multifaceted intervention plan was implemented: contact isolation, optimization of infection control and decolonization of all MRSA carriers. Thirty-two patients and five staff members were found to be MRSA carriers. Twenty one of 32 (66%) patients and all five staff members were successfully decolonized. Seven of 32 (22%) patients died during the epidemic before decolonization. A couple was discharged with persisting MRSA colonization and two individuals were lost to follow-up. The eradication of the epidemic clone was proven by systematic screenings in 1995 and 1997. Since then, the strain has no longer been identified in our institution, based on epidemiological surveillance and molecular typing of all MRSA strains obtained from any specimen. This study provides strong evidence that long-term eradication of an MRSA epidemic in a hospital is feasible, and endemicity of MRSA after an outbreak can be avoided. The successful bundle approach for eradication of MRSA during an epidemic is expensive, but the long-term benefits likely outweigh the initial heavy use of resources
Published: 2018

20. Secular Trend and Risk Factors for Antimicrobial Resistance in Escherichia coli Isolates in Switzerland 1997-2007

Author: Blaettler, L., Mertz, D., Frei, R., Elzi, L., Widmer, A., Battegay, M., Flückiger, U., Blaettler, L., Mertz, D., Frei, R., Elzi, L., Widmer, A., Battegay, M., and Flückiger, U.
Abstract: Background: : Antibacterial resistance in Escherichia coli isolates of urinary infections, mainly to fluoroquinolones, is emerging. The aim of our study was to identify the secular trend of resistant E. coli isolates and to characterize the population at risk for colonization or infections with these organisms. Patients and Methods: : Retrospective analysis of 3,430 E.coli first isolates of urine specimens from patients admitted to the University Hospital Basel in 1997, 2000, 2003, and 2007. Results: : Resistance to ciprofloxacin, trimethoprim/sulfamethoxazole, and amoxicillin/clavulanate has increased over the 10-year study period (from 1.8% to 15.9%, 17.4% to 21.3%, and 9.5% to 14.5%, respectively). A detailed analysis of the 2007 data revealed that independent risk factors for ciprofloxacin resistance were age (5.3% < 35 years of age to 21.9% in patients > 75 years; odds ratio [OR] 1.29 per 10 years, 95% confidence interval [CI] 1.15-1.45, p < 0.001) and male gender (OR 1.59, 95% CI 1.05-2.41, p = 0.04). In contrast, nosocomial E. coli isolates were associated with lower odds of ciprofloxacin resistance (OR 0.51, 95% CI 0.28-0.67, p < 0.001). The frequency of resistant isolate rates was not influenced by the clinical significance (i.e., colonization vs urinary tract infection, UTI) or by whether the urine was taken from a urinary catheter. Importantly, the increase in ciprofloxacin resistance paralleled the increase in ciprofloxacin consumption in Switzerland (Pearson's correlation test R2= 0.998, p = 0.002). Of note, resistance was less frequent in isolates sent in by general practitioners. However, after adjustment for age and gender, only resistance against amoxicillin/clavulanate was found to be less frequent (OR 0.34, 95% CI 0.16-0.92, p = 0.03). Conclusion: : Our study reveals that resistance rates have been increasing during the last decade. Published resistance rates may lack information due to important differences regarding age, gender, and p
Published: 2018

21. How much money can be saved by applying intravenous antibiotics once instead of several times a day?

Author: Mertz, D., Plagge, H., Bassetti, S., Battegay, M., Widmer, A., Mertz, D., Plagge, H., Bassetti, S., Battegay, M., and Widmer, A.
Abstract: Background: The preparation, administration and monitoring of intravenous (IV) applications are time consuming and require human resources. We estimated the potential time and cost savings by replacing antibiotics given 3-4 times daily with antibiotics with similar spectrum and efficacy given once daily. Methods: The savings of indirect costs were estimated based on the antibiotic consumption data of a two-year period (i.e. 2007 and 2008), a nurse's mean workload per application and the average nurse's salary in Switzerland. Results: The consumption of IV antibiotics in 2007 and 2008 at the University Hospital of Basel was 29.0 and 32.2 defined daily doses (DDD) per 100 patient days, respectively. Nurses spent an estimated 13,786h on the application of the estimated 82,715 does of IV antibiotics. A total of 56,404 applications or nursing staff time costs of 338,436 Swiss Francs (CHF; 236,669 €), equal to 16% of the overall costs spent on purchasing antibiotics in the year 2008, may have been saved by switching multiple-dose antibiotics to a hypothetical once-daily antibiotic. Including disposable materials, 21% or 456,884 CHF (319,499 €) could be saved annually (purchase costs not taken into account). Conclusion: We found a potential cost saving of 21% of the purchase costs in a 750-bed institution. Hence, indirect costs should be included in the calculation of the total cost for the application of broad-spectrum IV antibiotics. Switching from a 3-4 times daily application to a once-daily antibiotic should be considered if a once-daily antibiotic is deemed equally effective and has a similar spectrum
Published: 2018

22. Oligoarthritis durch Tropheryma whipplei: 'Of bugs and joints'

Author: Koligi, K., Mertz, D., Benz, D., Vogt, T., Bloemberg, G.V., Winter, L., Tyndall, A., Battegay, M., Walker, U.A., Koligi, K., Mertz, D., Benz, D., Vogt, T., Bloemberg, G.V., Winter, L., Tyndall, A., Battegay, M., and Walker, U.A.
Abstract: Zusammenfassung: Der Morbus Whipple ist eine seltene, ohne antibiotische Therapie schwer verlaufende, chronische Infektionserkrankung durch Tropheryma whipplei, ein ubiquitär vorkommendes, grampositives Bakterium. Der Erreger kann in den betroffenen Geweben und Körperflüssigkeiten durch histologischen Nachweis PAS-positiver Makrophagen, elektronenmikroskopisch und in der Polymerasekettenreaktion (PCR) nachgewiesen werden. Arthralgien und Arthritiden sind ein häufiges Primärsymptom dieser Multisystemerkrankung. Im Verlauf treten häufig Gewichtsverlust, Diarrhö und Abdominalschmerzen auf. In 10-40% der Krankheitsfälle bestehen zusätzlich neurologische Symptome. Wir berichten über einen 67-jährigen Patienten mit jahrzehntelanger Oligoarthritis, bei dem der Erreger mittels PCR ausschließlich in der Synovialflüssigkeit nachgewiesen werden konnte. Dieser Fall illustriert, dass der charakteristische Befund PAS-positiver Makrophagen und selbst die erregerspezifische PCR im Dünndarmgewebe negativ sein kann, sodass der Erregernachweis aus dem jeweils symptomatischen Organsystem angestrebt werden sollte. Die mehrmonatige bis mehrjährige Behandlung erfolgt möglichst mit liquorgängigen Antibiotika, typischerweise mit Ceftriaxon, gefolgt von Cotrimoxazol. Vor Abschluss der Therapie ist der Nachweis der Erregerfreiheit im Darm, Liquor bzw. im betroffenen Organ anzustreben
Published: 2018

23. Stronger correlation between antibiotic use and the incidence of Clostridium difficile determined by culture results instead of faecal toxin detection only

Author: Mertz, D., Frei, R., Plagge, H., Battegay, M., Widmer, A., Mertz, D., Frei, R., Plagge, H., Battegay, M., and Widmer, A.
Abstract: The detection of Clostridium difficile in previous studies evaluating antibiotic use as a risk factor was limited to toxin assay tests. The reported associations may have been misleading due to the low sensitivity of toxin assay tests compared to culture results. Antibiotic use and the incidence of C. difficile of 19 units (wards) over 5years were analysed. Stool samples were tested for toxin A/B and cultured. The correlation of antibiotic use with the incidence of C. difficile determined by culture results was compared to the correlation determined by toxin assay results. Additionally, single antibiotics were analysed as risk factors. Of 5,772 faecal samples tested for C. difficile, 154 single-first cases were detected by the toxin assay and 251 additional single-first cases by culture. Antibiotic use was a significantly stronger risk factor in the correlation based on the culture results (R 2 = 0.63) versus toxin assay results (R 2 = 0.40). Multivariate analysis did not improve the correlation significantly and only the group of broad-spectrum beta-lactams was identified as an independent risk factor. The correlation between antibiotic use and C. difficile incidence rates significantly improves if detection is not limited to faecal toxin assays. Therefore, antibiotic pressure was previously underestimated as a risk factor
Published: 2018

24. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) (vol 11, 33, 2016)

Author: Sartelli, M., Weber, D. G., Ruppe, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrn, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Junior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., Van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Sartelli, M., Weber, D. G., Ruppe, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrn, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Junior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., Van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., and Viale, P.
Published: 2017

25. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author: Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, Kiguba, R, Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R
Abstract: © The Author(s). The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'.
Published: 2017

26. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) (vol 11, 33, 2016)

Author: Sartelli, M., Weber, D. G., Ruppe, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrn, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Junior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., Van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Sartelli, M., Weber, D. G., Ruppe, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrn, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Junior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., Van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., and Viale, P.
Published: 2017

27. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Author: Goldenberg, JZ, Yap, C, Lytvyn, L, Lo, CKF, Beardsley, J, Mertz, D, Johnston, BC, Goldenberg, JZ, Yap, C, Lytvyn, L, Lo, CKF, Beardsley, J, Mertz, D, and Johnston, BC
Abstract: © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Antibiotics can disturb gastrointestinal microbiota which may lead to reduced resistance to pathogens such as Clostridium difficile (C. difficile). Probiotics are live microbial preparations that, when administered in adequate amounts, may confer a health benefit to the host, and are a potential C. difficile prevention strategy. Recent clinical practice guidelines do not recommend probiotic prophylaxis, even though probiotics have the highest quality evidence among cited prophylactic therapies. Objectives: To assess the efficacy and safety of probiotics for preventing C.difficile-associated diarrhea (CDAD) in adults and children. Search methods: We searched PubMed, EMBASE, CENTRAL, and the Cochrane IBD Group Specialized Register from inception to 21 March 2017. Additionally, we conducted an extensive grey literature search. Selection criteria: Randomized controlled (placebo, alternative prophylaxis, or no treatment control) trials investigating probiotics (any strain, any dose) for prevention of CDAD, or C. difficile infection were considered for inclusion. Data collection and analysis: Two authors (independently and in duplicate) extracted data and assessed risk of bias. The primary outcome was the incidence of CDAD. Secondary outcomes included detection of C. difficile infection in stool, adverse events, antibiotic-associated diarrhea (AAD) and length of hospital stay. Dichotomous outcomes (e.g. incidence of CDAD) were pooled using a random-effects model to calculate the risk ratio (RR) and corresponding 95% confidence interval (95% CI). We calculated the number needed to treat for an additional beneficial outcome (NNTB) where appropriate. Continuous outcomes (e.g. length of hospital stay) were pooled using a random-effects model to calculate the mean difference and corresponding 95% CI. Sensitivity analyses were conducted to explore the impact of missing data on efficacy and safet
Published: 2017

28. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Author: Goldenberg, JZ, Yap, C, Lytvyn, L, Lo, CKF, Beardsley, J, Mertz, D, Johnston, BC, Goldenberg, JZ, Yap, C, Lytvyn, L, Lo, CKF, Beardsley, J, Mertz, D, and Johnston, BC
Abstract: © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Antibiotics can disturb gastrointestinal microbiota which may lead to reduced resistance to pathogens such as Clostridium difficile (C. difficile). Probiotics are live microbial preparations that, when administered in adequate amounts, may confer a health benefit to the host, and are a potential C. difficile prevention strategy. Recent clinical practice guidelines do not recommend probiotic prophylaxis, even though probiotics have the highest quality evidence among cited prophylactic therapies. Objectives: To assess the efficacy and safety of probiotics for preventing C.difficile-associated diarrhea (CDAD) in adults and children. Search methods: We searched PubMed, EMBASE, CENTRAL, and the Cochrane IBD Group Specialized Register from inception to 21 March 2017. Additionally, we conducted an extensive grey literature search. Selection criteria: Randomized controlled (placebo, alternative prophylaxis, or no treatment control) trials investigating probiotics (any strain, any dose) for prevention of CDAD, or C. difficile infection were considered for inclusion. Data collection and analysis: Two authors (independently and in duplicate) extracted data and assessed risk of bias. The primary outcome was the incidence of CDAD. Secondary outcomes included detection of C. difficile infection in stool, adverse events, antibiotic-associated diarrhea (AAD) and length of hospital stay. Dichotomous outcomes (e.g. incidence of CDAD) were pooled using a random-effects model to calculate the risk ratio (RR) and corresponding 95% confidence interval (95% CI). We calculated the number needed to treat for an additional beneficial outcome (NNTB) where appropriate. Continuous outcomes (e.g. length of hospital stay) were pooled using a random-effects model to calculate the mean difference and corresponding 95% CI. Sensitivity analyses were conducted to explore the impact of missing data on efficacy and safet
Published: 2017

29. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author: Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, Kiguba, R, Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R
Abstract: © The Author(s). The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'.
Published: 2017

30. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author: Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, Ferdinando, Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, Swati, Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, Gabriele, Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Sganga, G. (ORCID:0000-0001-5079-0395), Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, Ferdinando, Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, Swati, Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, Gabriele, Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., and Sganga, G. (ORCID:0000-0001-5079-0395)
Abstract: The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'.
Published: 2017

31. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, M., Weber, D.G., Ruppe, E., Bassetti, M., Wright, B.J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F.M., Coimbra, R., Moore, E.E., Moore, F.A., Maier, R.V., Waele, J.J. De, Kirkpatrick, A.W., Griffiths, E.A., Eckmann, C., Brink, A.J., Mazuski, J.E., May, A.K., Sawyer, R.G., Mertz, D., Montravers, P., Kumar, A., Roberts, J.A., Vincent, J.L., Watkins, R.R., Lowman, W., Spellberg, B., Abbott, I.J., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Agresta, F., Althani, A.A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z.J., Baraket, O., Bhangu, A., Beltran, M.A., Bernhard, M., Biffl, W.L., Boermeester, M.A., Brecher, S.M., Cherry-Bukowiec, J.R., Buyne, O.R., Cainzos, M.A., Cairns, K.A., Camacho-Ortiz, A., Chandy, S.J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., Simone, B. De, Dhingra, S., Diaz, J.J., Carlo, I. Di, Dillip, A., Saverio, S. Di, Doyle, M.P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S.R., Enani, M.A., Egiev, V.N., Elmangory, M.M., Ferrada, P., Fitchett, J.R., Fraga, G.P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S.R., Gomes, C.A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W.R., Herzog, T., Hodonou, A.M., Hong, S.K., Kafka-Ritsch, R., Kaplan, L.J., Kapoor, G., Karamarkovic, A., Kees, M.G., Kenig, J., Kiguba, R., et al., Sartelli, M., Weber, D.G., Ruppe, E., Bassetti, M., Wright, B.J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F.M., Coimbra, R., Moore, E.E., Moore, F.A., Maier, R.V., Waele, J.J. De, Kirkpatrick, A.W., Griffiths, E.A., Eckmann, C., Brink, A.J., Mazuski, J.E., May, A.K., Sawyer, R.G., Mertz, D., Montravers, P., Kumar, A., Roberts, J.A., Vincent, J.L., Watkins, R.R., Lowman, W., Spellberg, B., Abbott, I.J., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Agresta, F., Althani, A.A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z.J., Baraket, O., Bhangu, A., Beltran, M.A., Bernhard, M., Biffl, W.L., Boermeester, M.A., Brecher, S.M., Cherry-Bukowiec, J.R., Buyne, O.R., Cainzos, M.A., Cairns, K.A., Camacho-Ortiz, A., Chandy, S.J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., Simone, B. De, Dhingra, S., Diaz, J.J., Carlo, I. Di, Dillip, A., Saverio, S. Di, Doyle, M.P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S.R., Enani, M.A., Egiev, V.N., Elmangory, M.M., Ferrada, P., Fitchett, J.R., Fraga, G.P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S.R., Gomes, C.A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W.R., Herzog, T., Hodonou, A.M., Hong, S.K., Kafka-Ritsch, R., Kaplan, L.J., Kapoor, G., Karamarkovic, A., Kees, M.G., Kenig, J., Kiguba, R., and et al.
Abstract: Contains fulltext : 168575.pdf (publisher's version ) (Open Access), Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

32. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, M., Weber, D.G., Ruppe, E., Bassetti, M., Wright, B.J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F.M., Coimbra, R., Moore, E.E., Moore, F.A., Maier, R.V., Waele, J.J. De, Kirkpatrick, A.W., Griffiths, E.A., Eckmann, C., Brink, A.J., Mazuski, J.E., May, A.K., Sawyer, R.G., Mertz, D., Montravers, P., Kumar, A., Roberts, J.A., Vincent, J.L., Watkins, R.R., Lowman, W., Spellberg, B., Abbott, I.J., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Agresta, F., Althani, A.A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z.J., Baraket, O., Bhangu, A., Beltran, M.A., Bernhard, M., Biffl, W.L., Boermeester, M.A., Brecher, S.M., Cherry-Bukowiec, J.R., Buyne, O.R., Cainzos, M.A., Cairns, K.A., Camacho-Ortiz, A., Chandy, S.J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., Simone, B. De, Dhingra, S., Diaz, J.J., Carlo, I. Di, Dillip, A., Saverio, S. Di, Doyle, M.P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S.R., Enani, M.A., Egiev, V.N., Elmangory, M.M., Ferrada, P., Fitchett, J.R., Fraga, G.P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S.R., Gomes, C.A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W.R., Herzog, T., Hodonou, A.M., Hong, S.K., Kafka-Ritsch, R., Kaplan, L.J., Kapoor, G., Karamarkovic, A., Kees, M.G., Kenig, J., Kiguba, R., et al., Sartelli, M., Weber, D.G., Ruppe, E., Bassetti, M., Wright, B.J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F.M., Coimbra, R., Moore, E.E., Moore, F.A., Maier, R.V., Waele, J.J. De, Kirkpatrick, A.W., Griffiths, E.A., Eckmann, C., Brink, A.J., Mazuski, J.E., May, A.K., Sawyer, R.G., Mertz, D., Montravers, P., Kumar, A., Roberts, J.A., Vincent, J.L., Watkins, R.R., Lowman, W., Spellberg, B., Abbott, I.J., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Agresta, F., Althani, A.A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z.J., Baraket, O., Bhangu, A., Beltran, M.A., Bernhard, M., Biffl, W.L., Boermeester, M.A., Brecher, S.M., Cherry-Bukowiec, J.R., Buyne, O.R., Cainzos, M.A., Cairns, K.A., Camacho-Ortiz, A., Chandy, S.J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., Simone, B. De, Dhingra, S., Diaz, J.J., Carlo, I. Di, Dillip, A., Saverio, S. Di, Doyle, M.P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S.R., Enani, M.A., Egiev, V.N., Elmangory, M.M., Ferrada, P., Fitchett, J.R., Fraga, G.P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S.R., Gomes, C.A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W.R., Herzog, T., Hodonou, A.M., Hong, S.K., Kafka-Ritsch, R., Kaplan, L.J., Kapoor, G., Karamarkovic, A., Kees, M.G., Kenig, J., Kiguba, R., and et al.
Abstract: Contains fulltext : 168575.pdf (publisher's version ) (Open Access), Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

33. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, M., Weber, D.G., Ruppe, E., Bassetti, M., Wright, B.J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F.M., Coimbra, R., Moore, E.E., Moore, F.A., Maier, R.V., Waele, J.J. De, Kirkpatrick, A.W., Griffiths, E.A., Eckmann, C., Brink, A.J., Mazuski, J.E., May, A.K., Sawyer, R.G., Mertz, D., Montravers, P., Kumar, A., Roberts, J.A., Vincent, J.L., Watkins, R.R., Lowman, W., Spellberg, B., Abbott, I.J., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Agresta, F., Althani, A.A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z.J., Baraket, O., Bhangu, A., Beltran, M.A., Bernhard, M., Biffl, W.L., Boermeester, M.A., Brecher, S.M., Cherry-Bukowiec, J.R., Buyne, O.R., Cainzos, M.A., Cairns, K.A., Camacho-Ortiz, A., Chandy, S.J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., Simone, B. De, Dhingra, S., Diaz, J.J., Carlo, I. Di, Dillip, A., Saverio, S. Di, Doyle, M.P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S.R., Enani, M.A., Egiev, V.N., Elmangory, M.M., Ferrada, P., Fitchett, J.R., Fraga, G.P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S.R., Gomes, C.A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W.R., Herzog, T., Hodonou, A.M., Hong, S.K., Kafka-Ritsch, R., Kaplan, L.J., Kapoor, G., Karamarkovic, A., Kees, M.G., Kenig, J., Kiguba, R., et al., Sartelli, M., Weber, D.G., Ruppe, E., Bassetti, M., Wright, B.J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F.M., Coimbra, R., Moore, E.E., Moore, F.A., Maier, R.V., Waele, J.J. De, Kirkpatrick, A.W., Griffiths, E.A., Eckmann, C., Brink, A.J., Mazuski, J.E., May, A.K., Sawyer, R.G., Mertz, D., Montravers, P., Kumar, A., Roberts, J.A., Vincent, J.L., Watkins, R.R., Lowman, W., Spellberg, B., Abbott, I.J., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Agresta, F., Althani, A.A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z.J., Baraket, O., Bhangu, A., Beltran, M.A., Bernhard, M., Biffl, W.L., Boermeester, M.A., Brecher, S.M., Cherry-Bukowiec, J.R., Buyne, O.R., Cainzos, M.A., Cairns, K.A., Camacho-Ortiz, A., Chandy, S.J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., Simone, B. De, Dhingra, S., Diaz, J.J., Carlo, I. Di, Dillip, A., Saverio, S. Di, Doyle, M.P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S.R., Enani, M.A., Egiev, V.N., Elmangory, M.M., Ferrada, P., Fitchett, J.R., Fraga, G.P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S.R., Gomes, C.A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W.R., Herzog, T., Hodonou, A.M., Hong, S.K., Kafka-Ritsch, R., Kaplan, L.J., Kapoor, G., Karamarkovic, A., Kees, M.G., Kenig, J., Kiguba, R., and et al.
Abstract: Contains fulltext : 168575.pdf (publisher's version ) (Open Access), Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

34. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, Kiguba, R, Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R
Abstract: © 2016 The Author(s). Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

35. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, Kiguba, R, Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R
Abstract: © 2016 The Author(s). Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

36. Seismic reflection profiling of the Baza sedimentary basin (Betics, Southern Spain)

Author: Stiller, Manfred, Haberland, C., Gibert, L., Jurado, Juan José, Scott, G., Mertz, D., Stiller, Manfred, Haberland, C., Gibert, L., Jurado, Juan José, Scott, G., and Mertz, D.
Abstract: The Baza Basin is an intra-mountain evaporitic basin in Southern Spain. It is the largest of the Late Neogene continental basins of the Betic Cordillera. During the last 7 million years the basin alternately was flooded and fell dry. Therefore, up to 2.5 km thick lacustrine and ancillary continental deposits are found which provide an unique archive of climatic changes and paleo-climatic events.
Published: 2016

37. Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

Author: Mertz, D, Affolter-Zbaraszczuk, C, Barthes, J, Cui, J, Caruso, F, Baumert, TF, Voegel, J-C, Ogier, J, Meyer, F, Mertz, D, Affolter-Zbaraszczuk, C, Barthes, J, Cui, J, Caruso, F, Baumert, TF, Voegel, J-C, Ogier, J, and Meyer, F
Abstract: In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and grafted with gadolinium complexes having average sizes ranging from ca. 50 to 150 nm according to the siRNA/HSA composition. The non-covalent siRNA/HSA assembly is formed on isobutyramide-modified mesoporous silica and the self-supported HSA-based nanoparticles are obtained following the silica template dissolution. These original protein particles provide simultaneous magnetic resonance imaging contrast enhancement and cellular in vitro gene silencing.
Published: 2014

38. Revealing the sedimentary structure of the Baza Basin (Southern Spain) using seismic reflection profiling. 16th SEISMIX International Symposium, October 12-17, 2014, Castelldefels, Barcelona

Author: Stiller, Manfred, Baumann-Wilke, Maria, Haberland, C., Gibert, Luis, Jurado, Maria José, Scott, Gary, Mertz, D., Stiller, Manfred, Baumann-Wilke, Maria, Haberland, C., Gibert, Luis, Jurado, Maria José, Scott, Gary, and Mertz, D.
Published: 2014

39. Understanding melt generation beneath the slow-spreading Kolbeinsey Ridge using 238U, 230Th, and 231Pa excesses

Author: Elkins, L. J., Sims, K. W. W., Prytulak, J., Elliott, T., Mattielli, N., Blichert-Toft, J., Blusztajn, J., Dunbar, N., Devey, Colin, Mertz, D. F., Schilling, J.-G., Murrell, M., Elkins, L. J., Sims, K. W. W., Prytulak, J., Elliott, T., Mattielli, N., Blichert-Toft, J., Blusztajn, J., Dunbar, N., Devey, Colin, Mertz, D. F., Schilling, J.-G., and Murrell, M.
Abstract: To examine the petrogenesis and sources of basalts from the Kolbeinsey Ridge, one of the shallowest locations along the global ridge system, we present new measurements of Nd, Sr, Hf, and Pb isotopes and U-series disequilibria on 32 axial basalts. Young Kolbeinsey basalts (full-spreading rate = 1.8 cm/yr; 67°05′–70°26′N) display (230Th/238U) < 1 and (230Th/238U) > 1 with (230Th/238U) from 0.95 to 1.30 and have low U (11.3–65.6 ppb) and Th (33.0 ppb–2.40 ppm) concentrations. Except for characteristic isotopic enrichment near the Jan Mayen region, the otherwise depleted Kolbeinsey basalts (e.g. 87Sr/86Sr = 0.70272–0.70301, εNd = 8.4–10.5, εHf = 15.4–19.6 (La/Yb)N = 0.28–0.84) encompass a narrow range of (230Th/232Th) (1.20–1.32) over a large range in (238U/232Th) (0.94–1.32), producing a horizontal array on a (230Th/232Th) vs. (238U/232Th) diagram and a large variation in (230Th/238U). However, the (230Th/238U) of the Kolbeinsey Ridge basalts (0.96–1.30) are inversely correlated with (234U/238U) (1.001–1.031). Samples with low (230Th/238U) and elevated (234U/238U) reflect alteration by seawater or seawater-derived materials. The unaltered Kolbeinsey lavas with equilibrium 234U/238U have high (230Th/238U) values (>=1.2), which are consistent with melting in the presence of garnet. This is in keeping with the thick crust and anomalously shallow axial depth for the Kolbeinsey Ridge, which is thought to be the product of large degrees of melting in a long melt column. A time-dependent, dynamic melting scenario involving a long, slowly upwelling melting column that initiates well within the garnet peridotite stability zone can, in general, reproduce the (230Th/238U) and (231Pa/235U) ratios in uncontaminated Kolbeinsey lavas, but low (231Pa/235U) ratios in Eggvin Bank samples suggest eclogite involvement in the source for that ridge segment.
Published: 2011

40. Late Cenozoic volcanism in the western Woodlark Basin area, SW Pacific: the sources of marine volcanic ash layers based on their elemental and Sr-Nd isotope compositions

Author: Lackschewitz, Klas, Mertz, D. F., Devey, Colin W., Garbe-Schönberg, C.-Dieter, Lackschewitz, Klas, Mertz, D. F., Devey, Colin W., and Garbe-Schönberg, C.-Dieter
Abstract: Tephra fallout layers and volcaniclastic deposits, derived from volcanic sources around and on the Papuan Peninsula, form a substantial part of the Woodlark Basin marine sedimentary succession. Sampling by the Ocean Drilling Program Leg 180 in the western Woodlark Basin provides the opportunity to document the distribution of the volcanically-derived components as well as to evaluate their chronology, chemistry, and isotope compositions in order to gain information on the volcanic sources and original magmatic systems. Glass shards selected from 57 volcanogenic layers within the sampled Pliocene–Pleistocene sedimentary sequence show predominantly rhyolitic compositions, with subordinate basaltic andesites, basaltic trachy-andesites, andesites, trachy-andesites, dacites, and phonolites. It was possible to correlate only a few of the volcanogenic layers between sites using geochemical and age information apparently because of the formation of strongly compartmentalised sedimentary realms on this actively rifting margin. In many cases it was possible to correlate Leg 180 volcanic components with their eruption source areas based on chemical and isotope compositions. Likely sources for a considerable number of the volcanogenic deposits are Moresby and Dawson Strait volcanoes (D’Entrecasteaux Islands region) for high-K calc-alkaline glasses. The Dawson Strait volcanoes appear to represent the source for five peralkaline tephra layers. One basaltic andesitic volcaniclastic layer shows affinities to basaltic andesites from the Woodlark spreading tip and Cheshire Seamount. For other layers, a clear identification of the sources proved impossible, although their isotope and chemical signatures suggest similarities to south-west Pacific subduction volcanism, e.g. New Britain and Tonga– Kermadec island arcs. Volcanic islands in the Trobriand Arc (for example, Woodlark Island Amphlett Islands and/ or Egum Atoll) are probable sources for several volcaniclastic layers with ages b
Published: 2003
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41. Late Cenozoic volcanism in the western Woodlark Basin area, SW Pacific: the sources of marine volcanic ash layers based on their elemental and Sr-Nd isotope compositions

Author: Lackschewitz, Klas, Mertz, D. F., Devey, Colin W., Garbe-Schönberg, C.-Dieter, Lackschewitz, Klas, Mertz, D. F., Devey, Colin W., and Garbe-Schönberg, C.-Dieter
Abstract: Tephra fallout layers and volcaniclastic deposits, derived from volcanic sources around and on the Papuan Peninsula, form a substantial part of the Woodlark Basin marine sedimentary succession. Sampling by the Ocean Drilling Program Leg 180 in the western Woodlark Basin provides the opportunity to document the distribution of the volcanically-derived components as well as to evaluate their chronology, chemistry, and isotope compositions in order to gain information on the volcanic sources and original magmatic systems. Glass shards selected from 57 volcanogenic layers within the sampled Pliocene–Pleistocene sedimentary sequence show predominantly rhyolitic compositions, with subordinate basaltic andesites, basaltic trachy-andesites, andesites, trachy-andesites, dacites, and phonolites. It was possible to correlate only a few of the volcanogenic layers between sites using geochemical and age information apparently because of the formation of strongly compartmentalised sedimentary realms on this actively rifting margin. In many cases it was possible to correlate Leg 180 volcanic components with their eruption source areas based on chemical and isotope compositions. Likely sources for a considerable number of the volcanogenic deposits are Moresby and Dawson Strait volcanoes (D’Entrecasteaux Islands region) for high-K calc-alkaline glasses. The Dawson Strait volcanoes appear to represent the source for five peralkaline tephra layers. One basaltic andesitic volcaniclastic layer shows affinities to basaltic andesites from the Woodlark spreading tip and Cheshire Seamount. For other layers, a clear identification of the sources proved impossible, although their isotope and chemical signatures suggest similarities to south-west Pacific subduction volcanism, e.g. New Britain and Tonga– Kermadec island arcs. Volcanic islands in the Trobriand Arc (for example, Woodlark Island Amphlett Islands and/ or Egum Atoll) are probable sources for several volcaniclastic layers with ages b
Published: 2003
Full Text: View/download PDF

42. Late Cenozoic volcanism in the western Woodlark Basin area, SW Pacific: the sources of marine volcanic ash layers based on their elemental and Sr-Nd isotope compositions

Author: Lackschewitz, Klas, Mertz, D. F., Devey, Colin W., Garbe-Schönberg, C.-Dieter, Lackschewitz, Klas, Mertz, D. F., Devey, Colin W., and Garbe-Schönberg, C.-Dieter
Abstract: Tephra fallout layers and volcaniclastic deposits, derived from volcanic sources around and on the Papuan Peninsula, form a substantial part of the Woodlark Basin marine sedimentary succession. Sampling by the Ocean Drilling Program Leg 180 in the western Woodlark Basin provides the opportunity to document the distribution of the volcanically-derived components as well as to evaluate their chronology, chemistry, and isotope compositions in order to gain information on the volcanic sources and original magmatic systems. Glass shards selected from 57 volcanogenic layers within the sampled Pliocene–Pleistocene sedimentary sequence show predominantly rhyolitic compositions, with subordinate basaltic andesites, basaltic trachy-andesites, andesites, trachy-andesites, dacites, and phonolites. It was possible to correlate only a few of the volcanogenic layers between sites using geochemical and age information apparently because of the formation of strongly compartmentalised sedimentary realms on this actively rifting margin. In many cases it was possible to correlate Leg 180 volcanic components with their eruption source areas based on chemical and isotope compositions. Likely sources for a considerable number of the volcanogenic deposits are Moresby and Dawson Strait volcanoes (D’Entrecasteaux Islands region) for high-K calc-alkaline glasses. The Dawson Strait volcanoes appear to represent the source for five peralkaline tephra layers. One basaltic andesitic volcaniclastic layer shows affinities to basaltic andesites from the Woodlark spreading tip and Cheshire Seamount. For other layers, a clear identification of the sources proved impossible, although their isotope and chemical signatures suggest similarities to south-west Pacific subduction volcanism, e.g. New Britain and Tonga– Kermadec island arcs. Volcanic islands in the Trobriand Arc (for example, Woodlark Island Amphlett Islands and/ or Egum Atoll) are probable sources for several volcaniclastic layers with ages b
Published: 2003
Full Text: View/download PDF

43. Giving birth to hotspot volcanoes: Distribution and composition of young seamounts from the seafloor near Tahiti and Pitcairn

Author: Devey, Colin W., Lackschewitz, Klas, Mertz, D. F., Bourdon, B., Cheminee, J.-L., Dubois, J., Guivel, C., Hekinian, R., Stoffers, Peter, Devey, Colin W., Lackschewitz, Klas, Mertz, D. F., Bourdon, B., Cheminee, J.-L., Dubois, J., Guivel, C., Hekinian, R., and Stoffers, Peter
Abstract: Apart from being popular holiday destinations, oceanic-island volcanoes such as Hawaii, Tahiti, or the Canaries provide magmas that yield valuable information about the interior of our planet. Until recently, studies have concentrated on the easily accessible, subaerial parts of the volcanoes, largely ignoring their earlier-formed, submarine parts. These submarine parts, however, provide critical information about how the mantle begins to melt and about the lowest-melting-point mantle components—information not available from the subaerial volcanoes but highly relevant for the chemical evolution of the whole mantle. We present here compositional information from small (<500 m) volcanoes on the seafloor near Tahiti and Pitcairn Islands and show that these small volcanoes erupt only highly differentiated magmas. These early melts are derived exclusively from the most trace element–enriched, isotopically extreme mantle component, evidence that this component has the lowest melting temperature and is the first product of melting of a new batch of mantle. The geochemical mantle components (enriched mantle EM-I, EM-II) proposed in the 1980s to explain the compositional variations among oceanic volcanoes worldwide appear in reality to represent distinct rock masses in the mantle.
Published: 2003
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44. Giving birth to hotspot volcanoes: Distribution and composition of young seamounts from the seafloor near Tahiti and Pitcairn

Author: Devey, Colin W., Lackschewitz, Klas, Mertz, D. F., Bourdon, B., Cheminee, J.-L., Dubois, J., Guivel, C., Hekinian, R., Stoffers, Peter, Devey, Colin W., Lackschewitz, Klas, Mertz, D. F., Bourdon, B., Cheminee, J.-L., Dubois, J., Guivel, C., Hekinian, R., and Stoffers, Peter
Abstract: Apart from being popular holiday destinations, oceanic-island volcanoes such as Hawaii, Tahiti, or the Canaries provide magmas that yield valuable information about the interior of our planet. Until recently, studies have concentrated on the easily accessible, subaerial parts of the volcanoes, largely ignoring their earlier-formed, submarine parts. These submarine parts, however, provide critical information about how the mantle begins to melt and about the lowest-melting-point mantle components—information not available from the subaerial volcanoes but highly relevant for the chemical evolution of the whole mantle. We present here compositional information from small (<500 m) volcanoes on the seafloor near Tahiti and Pitcairn Islands and show that these small volcanoes erupt only highly differentiated magmas. These early melts are derived exclusively from the most trace element–enriched, isotopically extreme mantle component, evidence that this component has the lowest melting temperature and is the first product of melting of a new batch of mantle. The geochemical mantle components (enriched mantle EM-I, EM-II) proposed in the 1980s to explain the compositional variations among oceanic volcanoes worldwide appear in reality to represent distinct rock masses in the mantle.
Published: 2003
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45. Geochemistry of lavas from Mohns Ridge, Norwegian-Greenland Sea: implications for melting conditions and magma sources near Jan Mayen

Author: Haase, K. M., Devey, Colin W., Mertz, D. F., Stoffers, Peter, Garbe-Schönberg, C.-Dieter, Haase, K. M., Devey, Colin W., Mertz, D. F., Stoffers, Peter, and Garbe-Schönberg, C.-Dieter
Abstract: Mohns Ridge lavas between 71 and 72°30′N (∼360 km) have heterogeneous compositions varying between alkali basalts and incompatible-element-depleted tholeiites. On a large scale there is a continuity of incompatible element and isotopic compositions between the alkali basalts from the island Jan Mayen and Mohns Ridge tholeiites. The variation in isotopes suggests a heterogeneous mantle which appears to be tapped preferentially by low degree melts (∼5%) close to Jan Mayen but also shows its signature much further north on Mohns Ridge. Three lava types with different incompatible element compositions [e.g. chondrite-normalized (La/Sm)N<1 to >2] occur in the area at 72°N and were generated from this heterogeneous mantle. The relatively depleted tholeiitic melts were mixed with a small degree melt from an enriched source. The elements Ba, Rb and K of the enriched melt were probably buffered in the mantle by residual amphibole or phlogopite. That such a residual phase is stable in this region of oceanic mantle suggests both high water contents and low mantle temperatures, at odds with a hotspot origin for Jan Mayen. Instead we suggest that the melting may be induced by the lowered solidus temperature of a “wet” mantle. Mohns MORB (mid ocean ridge basalt) and Jan Mayen area alkali basalts have high contents of Ba and Rb compared to other incompatible elements (e.g. Ba/La >10). These ratios reflect the signature of the mantle source. Ratios of Ce/Pb and Rb/Cs are normal MORB mantle ratios of 25 and 80, respectively, thus the enrichments of Ba and Rb are not indicative of a sedimentary component added to the mantle source but were probably generated by the influence of a metasomatizing fluid, as supported by the presence of hydrous phases during the petrogenesis of the alkali basalts. Geophysical and petrological models suggest that Jan Mayen is not the product of hotspot activity above a mantle plume, and suggest instead that it owes its existence to the unique juxtapositio
Published: 1996
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46. Geochemistry of lavas from Mohns Ridge, Norwegian-Greenland Sea: implications for melting conditions and magma sources near Jan Mayen

Author: Haase, K. M., Devey, Colin W., Mertz, D. F., Stoffers, Peter, Garbe-Schönberg, C.-Dieter, Haase, K. M., Devey, Colin W., Mertz, D. F., Stoffers, Peter, and Garbe-Schönberg, C.-Dieter
Abstract: Mohns Ridge lavas between 71 and 72°30′N (∼360 km) have heterogeneous compositions varying between alkali basalts and incompatible-element-depleted tholeiites. On a large scale there is a continuity of incompatible element and isotopic compositions between the alkali basalts from the island Jan Mayen and Mohns Ridge tholeiites. The variation in isotopes suggests a heterogeneous mantle which appears to be tapped preferentially by low degree melts (∼5%) close to Jan Mayen but also shows its signature much further north on Mohns Ridge. Three lava types with different incompatible element compositions [e.g. chondrite-normalized (La/Sm)N<1 to >2] occur in the area at 72°N and were generated from this heterogeneous mantle. The relatively depleted tholeiitic melts were mixed with a small degree melt from an enriched source. The elements Ba, Rb and K of the enriched melt were probably buffered in the mantle by residual amphibole or phlogopite. That such a residual phase is stable in this region of oceanic mantle suggests both high water contents and low mantle temperatures, at odds with a hotspot origin for Jan Mayen. Instead we suggest that the melting may be induced by the lowered solidus temperature of a “wet” mantle. Mohns MORB (mid ocean ridge basalt) and Jan Mayen area alkali basalts have high contents of Ba and Rb compared to other incompatible elements (e.g. Ba/La >10). These ratios reflect the signature of the mantle source. Ratios of Ce/Pb and Rb/Cs are normal MORB mantle ratios of 25 and 80, respectively, thus the enrichments of Ba and Rb are not indicative of a sedimentary component added to the mantle source but were probably generated by the influence of a metasomatizing fluid, as supported by the presence of hydrous phases during the petrogenesis of the alkali basalts. Geophysical and petrological models suggest that Jan Mayen is not the product of hotspot activity above a mantle plume, and suggest instead that it owes its existence to the unique juxtapositio
Published: 1996
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47. Geochemistry of lavas from Mohns Ridge, Norwegian-Greenland Sea: implications for melting conditions and magma sources near Jan Mayen

Author: Haase, K. M., Devey, Colin W., Mertz, D. F., Stoffers, Peter, Garbe-Schönberg, C.-Dieter, Haase, K. M., Devey, Colin W., Mertz, D. F., Stoffers, Peter, and Garbe-Schönberg, C.-Dieter
Abstract: Mohns Ridge lavas between 71 and 72°30′N (∼360 km) have heterogeneous compositions varying between alkali basalts and incompatible-element-depleted tholeiites. On a large scale there is a continuity of incompatible element and isotopic compositions between the alkali basalts from the island Jan Mayen and Mohns Ridge tholeiites. The variation in isotopes suggests a heterogeneous mantle which appears to be tapped preferentially by low degree melts (∼5%) close to Jan Mayen but also shows its signature much further north on Mohns Ridge. Three lava types with different incompatible element compositions [e.g. chondrite-normalized (La/Sm)N<1 to >2] occur in the area at 72°N and were generated from this heterogeneous mantle. The relatively depleted tholeiitic melts were mixed with a small degree melt from an enriched source. The elements Ba, Rb and K of the enriched melt were probably buffered in the mantle by residual amphibole or phlogopite. That such a residual phase is stable in this region of oceanic mantle suggests both high water contents and low mantle temperatures, at odds with a hotspot origin for Jan Mayen. Instead we suggest that the melting may be induced by the lowered solidus temperature of a “wet” mantle. Mohns MORB (mid ocean ridge basalt) and Jan Mayen area alkali basalts have high contents of Ba and Rb compared to other incompatible elements (e.g. Ba/La >10). These ratios reflect the signature of the mantle source. Ratios of Ce/Pb and Rb/Cs are normal MORB mantle ratios of 25 and 80, respectively, thus the enrichments of Ba and Rb are not indicative of a sedimentary component added to the mantle source but were probably generated by the influence of a metasomatizing fluid, as supported by the presence of hydrous phases during the petrogenesis of the alkali basalts. Geophysical and petrological models suggest that Jan Mayen is not the product of hotspot activity above a mantle plume, and suggest instead that it owes its existence to the unique juxtapositio
Published: 1996
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48. Geochemical effects of dynamic melting beneath ridges: Reconciling major and trace element variations in Kolbeinsey (and global) mid-ocean ridge basalt

Author: Devey, Colin W., Garbe-Schönberg, C.-Dieter, Stoffers, Peter, Chauvel, C., Mertz, D. F., Devey, Colin W., Garbe-Schönberg, C.-Dieter, Stoffers, Peter, Chauvel, C., and Mertz, D. F.
Abstract: Zero-age basalts dredged from the Kolbeinsey Ridge directly north of Iceland are mafic quartz tholeiites (MgO 6-10 wt. %), strongly depleted in incompatible elements. Fractionation-corrected Na2O contents ('Na(sub 8)') are amongst the lowest found on the global ridge system, implying that the degree of partial melting at Kolbeinsey is amongst the highest for all mid-ocean ridge basalt (MORB). In contrast, the basalts show large ranges of incompatible-element ratios (e.g., K2O/TiO2 of 0.01 to 0.12 and Nd/Sm of 2.1 to 2.9) not related to variations in radiogenic isotope ratios; this suggests recent enrichment/depletion events associated with small-degree partial melting as their cause, rather than long-lived source heterogeneity. Tholeiitic MORB from many regions globally show similar or more extreme variations in K2O/TiO2. Dynamic melting of an adiabatically upwelling source can reconcile these conflicting indications of the degree of melting. Through dynamic melting, the incompatible elements are partially separated into different melt fractions based on their bulk partition coefficients, more incompatible elements being concentrated in deeper, smaller-degree partial melts. The final erupted magma is a mix of melts from all depths in the melting column. The concentration of highly incompatible elements in the mix will be very sensitive to the physical processes allowing the deep melts to separate and migrate to the site of mixing, and small fluctuations in the efficiency of the separation process can account for the large range of trace element ratios seen at Kolbeinsey. The major element chemistry of the erupted mix (and Na(sub 8) is much more robust, depending mainly on the integrated total amount of melting. The large variations of incompatible element ratios seen at Kolbeinsey, and in MORB in general, therefore give no information about the total degree of melting occuring beneath the ridge, nor do they require a heterogeneous source.
Published: 1994
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49. Geochemical effects of dynamic melting beneath ridges: Reconciling major and trace element variations in Kolbeinsey (and global) mid-ocean ridge basalt

Author: Devey, Colin W., Garbe-Schönberg, C.-Dieter, Stoffers, Peter, Chauvel, C., Mertz, D. F., Devey, Colin W., Garbe-Schönberg, C.-Dieter, Stoffers, Peter, Chauvel, C., and Mertz, D. F.
Abstract: Zero-age basalts dredged from the Kolbeinsey Ridge directly north of Iceland are mafic quartz tholeiites (MgO 6-10 wt. %), strongly depleted in incompatible elements. Fractionation-corrected Na2O contents ('Na(sub 8)') are amongst the lowest found on the global ridge system, implying that the degree of partial melting at Kolbeinsey is amongst the highest for all mid-ocean ridge basalt (MORB). In contrast, the basalts show large ranges of incompatible-element ratios (e.g., K2O/TiO2 of 0.01 to 0.12 and Nd/Sm of 2.1 to 2.9) not related to variations in radiogenic isotope ratios; this suggests recent enrichment/depletion events associated with small-degree partial melting as their cause, rather than long-lived source heterogeneity. Tholeiitic MORB from many regions globally show similar or more extreme variations in K2O/TiO2. Dynamic melting of an adiabatically upwelling source can reconcile these conflicting indications of the degree of melting. Through dynamic melting, the incompatible elements are partially separated into different melt fractions based on their bulk partition coefficients, more incompatible elements being concentrated in deeper, smaller-degree partial melts. The final erupted magma is a mix of melts from all depths in the melting column. The concentration of highly incompatible elements in the mix will be very sensitive to the physical processes allowing the deep melts to separate and migrate to the site of mixing, and small fluctuations in the efficiency of the separation process can account for the large range of trace element ratios seen at Kolbeinsey. The major element chemistry of the erupted mix (and Na(sub 8) is much more robust, depending mainly on the integrated total amount of melting. The large variations of incompatible element ratios seen at Kolbeinsey, and in MORB in general, therefore give no information about the total degree of melting occuring beneath the ridge, nor do they require a heterogeneous source.
Published: 1994
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50. Geochemical effects of dynamic melting beneath ridges: Reconciling major and trace element variations in Kolbeinsey (and global) mid-ocean ridge basalt

Author: Devey, Colin W., Garbe-Schönberg, C.-Dieter, Stoffers, Peter, Chauvel, C., Mertz, D. F., Devey, Colin W., Garbe-Schönberg, C.-Dieter, Stoffers, Peter, Chauvel, C., and Mertz, D. F.
Abstract: Zero-age basalts dredged from the Kolbeinsey Ridge directly north of Iceland are mafic quartz tholeiites (MgO 6-10 wt. %), strongly depleted in incompatible elements. Fractionation-corrected Na2O contents ('Na(sub 8)') are amongst the lowest found on the global ridge system, implying that the degree of partial melting at Kolbeinsey is amongst the highest for all mid-ocean ridge basalt (MORB). In contrast, the basalts show large ranges of incompatible-element ratios (e.g., K2O/TiO2 of 0.01 to 0.12 and Nd/Sm of 2.1 to 2.9) not related to variations in radiogenic isotope ratios; this suggests recent enrichment/depletion events associated with small-degree partial melting as their cause, rather than long-lived source heterogeneity. Tholeiitic MORB from many regions globally show similar or more extreme variations in K2O/TiO2. Dynamic melting of an adiabatically upwelling source can reconcile these conflicting indications of the degree of melting. Through dynamic melting, the incompatible elements are partially separated into different melt fractions based on their bulk partition coefficients, more incompatible elements being concentrated in deeper, smaller-degree partial melts. The final erupted magma is a mix of melts from all depths in the melting column. The concentration of highly incompatible elements in the mix will be very sensitive to the physical processes allowing the deep melts to separate and migrate to the site of mixing, and small fluctuations in the efficiency of the separation process can account for the large range of trace element ratios seen at Kolbeinsey. The major element chemistry of the erupted mix (and Na(sub 8) is much more robust, depending mainly on the integrated total amount of melting. The large variations of incompatible element ratios seen at Kolbeinsey, and in MORB in general, therefore give no information about the total degree of melting occuring beneath the ridge, nor do they require a heterogeneous source.
Published: 1994
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