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A new generation of high-performance, ultra-high strength (UHS) steelsSteel are required for lightweight applications at low prices. Traditionally, the outstanding properties of maraging (martensite-aging) steelsSteel emerge from semi-coherent nanoprecipitation in a martensitic matrix. However, coherency strains originating from the semi-coherent precipitates promote crackCrack initiation under load and thus inevitably reduce ductility. Multiple authors have suggested as a solution a highly-dense nanoprecipitation of Ni(AlAl,Fe) coherent precipitates with minimal latticeLattices misfit and validated the idea experimentally. In this work, we computationally designed, from processing to performance, a UHS steelSteel composed of Fe-Ni-Al-Mo with a higher specific yield strength and much lower price. Several foundational computational tools within the ICMEICME framework were adopted to design the steelSteel, including Thermo-Calc, TC-PRISMA, DICTRA, and TC-Python., Part of ISBN 9783031503481QC 20240307

We employ a chiral effective field theory-based approach to connect $DD^*$ scattering observables at the physical and variable pion masses accessible in lattice QCD simulations. We incorporate all relevant scales associated with three-body $DD\pi$ dynamics and the left-hand cut induced by the one-pion exchange for pion masses higher than the physical one, as required by analyticity and unitarity. By adjusting the contact interactions to match experimental data at the physical pion mass and lattice finite-volume energy levels at $m_{\pi} = 280$ MeV, we predict the trajectory of the $T_{cc}$ pole as a function of the pion mass, finding it consistent with the hadronic-molecule scenario. In particular, we find that the explicit treatment of the one-pion exchange has a pronounced effect on the pole trajectory for $m_\pi \gtrsim 230$ MeV by pushing it into the complex energy plane., Comment: 11 pages, 7 figures

We use the quark potential model to calculate the mass spectrum of the S-wave fully heavy tetraquark systems with different flavors, including the $ bc\bar b\bar c, bb\bar c\bar c, cc\bar c\bar b $ and $ bb\bar b\bar c $ systems. We employ the Gaussian expansion method to solve the four-body Schr\"odinger equation, and the complex scaling method to identify resonant states. The $ bc\bar b\bar c, bb\bar c\bar c, cc\bar c\bar b $ and $ bb\bar b\bar c $ resonant states are obtained in the mass regions of $ (13.2,13.5) $, $ (13.3,13.6) $, $ (10.0,10.3) $, $ (16.5,16.7) $ GeV, respectively. Among these states, the $ bc\bar b\bar c $ tetraquark states are the most promising ones to be discovered in the near future. We recommend the experimental exploration of the $ 1^{++} $ and $ 2^{++} $ $ bc\bar b\bar c $ states with masses near $ 13.3 $ GeV in the $ J/\psi\Upsilon $ channel. From the root-mean-square radii, we find that all the resonant states we have identified are compact tetraquark states., Comment: 10 pages,7 figures,8 tables

As a new generation of reactor type, lead-cooled fast reactors, have better safety behaviors, higher reliability, and better economic performance, aiming at island power supply through nuclear energy, seawater desalination, optimization of nuclear submarines, etc. Its evolution of nuclear waste and the advantages of nuclear non-proliferation provide a good prospect for development. This paper studied the safety performances of an offshore stationary lead-cooled reactor (OSLR) proposed in the National Key Research and Development Program of China. The transient analysis code SAS4A/SASSYS-1 was used to perform simulations of unprotected over-power accidents (UTOP) and unprotected loss of heat sink (ULOHS) accidents. The results indicated that offshore stationary lead-cooled reactors can withstand a maximum positive reactivity insertion of 0.5$ within 1 s during UTOP accidents without exceeding the working limits of the core. In ULOHS accidents, the inherent safety characteristics of OSLR allowed it to withstand 75 % heat removal capability of IHX. The simulation results were used to analyze the response of this stationary offshore reactor to transient accident conditions and the limits of its ability to withstand accidents in order to provide reference data for subsequent design and ideas for possible development of natural cycle lead-cooled reactors in the future., QC 20240821

The BESIII Collaboration recently observed a new charmonium-like vector state $Y(3872)$ in $e^+e^-\rightarrow D\bar{D}$, which should be the first P-wave $D\bar{D}^*/\bar{D}D^*$ molecular resonance. The experimental and theoretical identification of the P-wave dimeson state holds paramount importance in enhancing our comprehension of the non-perturbative QCD and few-body physics. Its existence is firmly established in a unified meson-exchange model which simultaneously depicts the features of the $\chi_{c1}(3872)$, $Z_c(3900)$ and $T_{cc}(3875)$. This scenario can be directly examined in the $e^+e^-\rightarrow D\bar{D}^*/\bar{D}D^*$ cross section to see whether a resonance exists at the threshold. The credibility of the investigations is also ensured by the fact that the P-wave interaction dominantly arises from the well-known long-range pion exchange. Additionally, the existence of the P-wave resonance only depends on the interaction strength and is less sensitive to the potential shapes. We extensively calculate all systems up to P-wave with various quantum numbers and predict a dense population of the $D\bar{D}^*/\bar{D}D^*$ and $DD^*$ states, where the S-wave $D\bar{D}^*/\bar{D}D^*$ state with $I^G (J^{PC})=0^- (1^{+-})$, P-wave $D\bar{D}^*/\bar{D}D^*$ state with $I^G(J^{PC})=0^+(0^{-+})$, and P-wave $DD^*$ state with $I(J^P)=0(0^-)$ are more likely to be observed in experiments., Comment: 9 pages, 7 figures

We calculate the mass spectrum of the S-wave fully heavy tetraquark systems $ QQ\bar Q\bar Q~(Q=c,b) $ with both normal $ (J^{PC}=0^{++},1^{+-},2^{++}) $ and exotic $ (J^{PC}=0^{+-},1^{++},2^{+-}) $ C-parities using three different quark potential models (AL1, AP1, BGS). The exotic C-parity systems refer to the ones that cannot be composed of two S-wave ground heavy quarkonia. We incorporate the molecular dimeson and compact diquark-antidiquark spatial correlations simultaneously, thereby discerning the actual configurations of the states. We employ the Gaussian expansion method to solve the four-body Schr\"odinger equation, and the complex scaling method to identify the resonant states. The mass spectra in three different models qualitatively agree with each other. We obtain several resonant states with $ J^{PC} = 0^{++}, 1^{+-}, 2^{++}, 1^{++} $ in the mass region $(6.92,7.30)\, \mathrm{GeV}$, some of which are good candidates of the experimentally observed $X(6900)$ and $X(7200)$. We also obtain several exotic C-parity zero-width states with $ J^{PC}=0^{+-} $ and $ 2^{+-} $. These zero-width states have no corresponding S-wave diquarkonium threshold and can only decay strongly to final states with P-wave quarkonia. With the notation $T_{4Q,J(C)}(M)$, we deduce from the root mean square radii that the $ X(7200) $ candidates $ T_{4c,0(+)}(7173), T_{4c,2(+)}(7214) $ and the state $ T_{4c,1(-)}(7191) $ look like molecular states although most of the resonant and zero-width states are compact states., Comment: 16 pages, 6 figures, 10 tables. Version accepted by PRD

The $X(3872)$, as the first and the most crucial member in the exotic charmoniumlike $XYZ$ family, has been studied for a long time. However, its dynamical origin, whether stemming from a $D\bar{D}^*$ hadronic molecule or the first excited $P$-wave charmonium $\chi_{c1}(2P)$, remains controversial. In this Letter, we demonstrate that the $X(3872)$ definitely does not result from the mass shift of the higher bare $\chi_{c1}(2P)$ resonance pole in the coupled-channel dynamics involving a short-distance $c\bar{c}$ core and the long-distance $D\bar{D}^*$ channels. Instead, it originates from either the $D\bar{D}^*$ molecular pole or the shadow pole associated with the $P$-wave charmonium, which depends on the concrete coupling mode between the $c\bar{c}$ and $D\bar{D}^*$. In order to further exploit the nature of $X(3872)$, we carefully investigate potential mechanisms that contribute to its pole width, which suggests that the coupled-channel dynamics plays a critical role in causing a noticeable discrepancy between the pole widths of $X(3872)$ and $T_{cc}^+$. Interestingly, we bridge the quantitative connection among the dynamics origin of $X(3872)$, its pole width and the properties of the predicted new resonance. The precise measurement of the pole width of $X(3872)$ and the search for the new charmoniumlike resonance become highly significant and can be anticipated in future LHCb, BESIII and Belle II experiments., Comment: 11 pages, 5 figures

Remarkable successes were made in Medical Image Classification (MIC) recently, mainly due to wide applications of convolutional neural networks (CNNs). However, adversarial examples (AEs) exhibited imperceptible similarity with raw data, raising serious concerns on network robustness. Although adversarial training (AT), in responding to malevolent AEs, was recognized as an effective approach to improve robustness, it was challenging to overcome generalization decline of networks caused by the AT. In this paper, in order to reserve high generalization while improving robustness, we proposed a dynamic perturbation-adaptive adversarial training (DPAAT) method, which placed AT in a dynamic learning environment to generate adaptive data-level perturbations and provided a dynamically updated criterion by loss information collections to handle the disadvantage of fixed perturbation sizes in conventional AT methods and the dependence on external transference. Comprehensive testing on dermatology HAM10000 dataset showed that the DPAAT not only achieved better robustness improvement and generalization preservation but also significantly enhanced mean average precision and interpretability on various CNNs, indicating its great potential as a generic adversarial training method on the MIC., Comment: 9 pages, 4 figures, 2 tables

The BESIII Collaboration recently observed a new charmonium-like vector state $Y(3872)$ in $e^+e^-\rightarrow D\bar{D}$, which should be the first P-wave $D\bar{D}^*/\bar{D}D^*$ molecular resonance. The experimental and theoretical identification of the P-wave dimeson state holds paramount importance in enhancing our comprehension of the non-perturbative QCD and few-body physics. Its existence is firmly established in a unified meson-exchange model which simultaneously depicts the features of the $\chi_{c1}(3872)$, $Z_c(3900)$ and $T_{cc}(3875)$. This scenario can be directly examined in the $e^+e^-\rightarrow D\bar{D}^*/\bar{D}D^*$ cross section to see whether a resonance exists at the threshold. The credibility of the investigations is also ensured by the fact that the P-wave interaction dominantly arises from the well-known long-range pion exchange. Additionally, the existence of the P-wave resonance only depends on the interaction strength and is less sensitive to the potential shapes. We extensively calculate all systems up to P-wave with various quantum numbers and predict a dense population of the $D\bar{D}^*/\bar{D}D^*$ and $DD^*$ states, where the S-wave $D\bar{D}^*/\bar{D}D^*$ state with $I^G (J^{PC})=0^- (1^{+-})$, P-wave $D\bar{D}^*/\bar{D}D^*$ state with $I^G(J^{PC})=0^+(0^{-+})$, and P-wave $DD^*$ state with $I(J^P)=0(0^-)$ are more likely to be observed in experiments., Comment: 9 pages, 7 figures

Fan Hu,1,2,* Meng-Lu Lin,1,2,* Juan-Li Mou,1,2,* Jia-Hui Feng,1,2 Kai Huang,1,2 Yao-Jia Lao,1,2 Jie Cheng,1,2 Jun Lin1,2 1Department of Gastroenterology/Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2The Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Lin, Email linjun64@126.comBackground: Carbapenem resistant Klebsiella pneumoniae (CRKP) is an independent risk factor for nosocomial infection which poses a serious threat to human health. How to prevent and suppress CRKP infection and explore its drug resistance mechanisms have become a huge challenge and possesses immediate significance.Methods: A total of 45 CRKP strains isolated from hospitalized patients in Zhongnan Hospital of Wuhan University were collected from August 2018-December 2020. The strain’s identification and antimicrobial susceptibility tests were performed using the VITEK 2 automated identification instrument. Single molecule DNA sequencing of 45 CRKP isolates was performed by the third generation high-throughput sequencing technology.Results: The results were analyzed by multi locus sequence typing (MLST) and phylogenetic analysis. Antimicrobial susceptibility showed that 45 CRKP isolates were multi-drug resistant strains, and the resistance rates to common antibiotics were as high as 68%. Whole genome sequencing results showed that the CRKP strains carried multiple drug resistance genes and virulence factors. MLST analysis found two different sequence types (ST), of which 44 were ST11 and 1 was ST1049.Conclusion: Through whole genome sequencing (WGS), we found multiple drug-resistant genes and virulence factors, and there was obvious dominant microbiota. The source was mainly related to nosocomial infection. The ST11-KPC Klebsiella pneumoniae was the main type, which was consistent with

We improve the complex scaling method (CSM) to obtain the virtual states, which were previously challenging in the conventional CSM. Our approach solves the Schr\"odinger equation in the momentum space as an eigenvalue problem by choosing the flexible contours. It proves to be highly effective in identifying the poles across the different Riemann sheets in the multi-channel scatterings. It is more straightforward and efficient than searching for the zeros of the Fredholm determinant of the Lippmann-Schwinger equation using the root-finding algorithms. This advancement significantly extends the capabilities of the CSM in accurately characterizing the resonances and virtual states in quantum systems., Comment: 12 pages, 14 figures, 2 tables

We relate the interactions of the $\bar{D}^{(\ast)} K^\ast$ and $D^{(\ast)} K^\ast$ systems to those of $D^{(\ast)}D^{(\ast)}$ and $D^{(\ast)}\bar{D}^{(\ast)}$ respectively, considering the residual strong interactions at the near-threshold energy is too weak to excite the strange quarks inside the hadrons. We propose an effective model to describe the low-energy S-wave interactions that are undertaken by the light $u$, $d$ quarks between two separated heavy hadrons. We find that the existence of molecules in the heavy-(anti)heavy sectors will naturally lead to the emergence of molecular states in $\bar{D}^{(\ast)} K^\ast$ and $D^{(\ast)} K^\ast$ systems. The recently observed $T_{cs0}(2900)$ and $T_{c\bar{s}0}^a(2900)$ can be well identified as the $0(0^+)$ and $1(0^+)$ partners of $T_{cc}(3875)$ and $Z_c(3900)$ in the charmed strange sector, respectively. We also predict their members under the {\it heavy} ($c$ and $s$) quark symmetry and SU(2) flavor symmetry. Most of them are very good molecule candidates, for example, (i) the $0(1^+)$ states in $D^\ast D^\ast$, $\bar{D}K^\ast$, $\bar{D}^\ast K^\ast$; (ii) the $0^{(+)}(2^{+(+)})$ states in $D^\ast \bar{D}^\ast$, $\bar{D}^\ast K^\ast$, $D^\ast K^\ast$; (iii) the $1^-(0^{++})$ state in $D^\ast\bar{D}^\ast$ and $1(1^+)$ state in $D^\ast K^\ast$. The $0^+(0^{++})$ state in $D\bar{D}$ and the $0(1^+)$ state in $DK^\ast$ might also exist as virtual states, and the $0(1^+)$ $DK^\ast$ can serve as a key to infer the existence of $0^+(0^{++})$ $D\bar{D}$. The $D_s\pi$ invariant mass spectrum of $T_{c\bar{s}0}^a(2900)$ is also studied within the coupled-channel approach, and the molecular interpretation of $T_{c\bar{s}0}^a(2900)$ is consistent with the experimental data. Searching for the predicted states in experiments is crucial to discriminate the different pictures for interpreting these near-threshold exotica., Comment: 12 pages, 6 figs, and 4 tables

IntroductionCOVID-19 vaccines are safe, effective, and widely available, but many adults in the U.S. have not been vaccinated for COVID-19. This study examined the associations between behavioral and social drivers of vaccination with COVID-19 vaccine uptake in the U.S. adults and their prevalence by region.MethodsA nationally representative sample of U.S. adults participated in a cross-sectional telephone survey in August-November 2021; the analysis was conducted in January 2022. Survey questions assessed self-reported COVID-19 vaccine initiation, demographics, and behavioral and social drivers of vaccination.ResultsAmong the 255,763 respondents, 76% received their first dose of COVID-19 vaccine. Vaccine uptake was higher among respondents aged ≥75 years (94%), females (78%), and Asian non-Hispanic people (94%). The drivers of vaccination most strongly associated with uptake included higher anticipated regret from nonvaccination, risk perception, and confidence in vaccine safety and importance, followed by work- or school-related vaccination requirements, social norms, and provider recommendation (all p<0.05). The direction of association with uptake varied by reported level of difficulty in accessing vaccines. The prevalence of all of these behavioral and social drivers of vaccination was highest in the Northeast region and lowest in the Midwest and South.ConclusionsThis nationally representative survey found that COVID-19 vaccine uptake was most strongly associated with greater anticipated regret, risk perception, and confidence in vaccine safety and importance, followed by vaccination requirements and social norms. Interventions that leverage these social and behavioral drivers of vaccination have the potential to increase COVID-19 vaccine uptake and could be considered for other vaccine introductions.

The China Initiative Accelerator Driven System (CiADS) was proposed by China Academy of Science since 2015. The subcritical reactor in CiADS is a liquid Lead Bismuth Eutectic (LBE) cooled fast reactor. When the reactor core is in operation, the LBE coolant will directly contact and corrode the inner surface of reactor vessel. Due to the high temperature, the corrosion will be more severe. If the stress on the reactor vessel exceeds the limit, the plastic deformation will occur, leading to the generation and expansion of defects and cracks, and the safety of the reactor will be affected. Therefore, evaluating the stress field of the reactor vessel under different operating conditions is a very important research project. In this paper, the finite element analysis software ADINA was applied to analyze the reactor vessel in CiADS, and the ASME Code was used as stress assessment standards. We can preliminarily prove that the stress assessments of the vessel during the postulated Unprotected Loss of Flow (ULOF) accidents satisfy the requirements of ASME Code. The limit reactivity insertion to protect the vessel from plastic deformation is 0.58$ in the postulated Unprotected Transient over Power (UTOP) accidents based on our current results. Therefore, we can preliminarily conclude that the current material selection and structural design of the reactor vessel in CiADS could survive most of the postulated transient accidents considering the stress effect., QC 20230911

We investigate the mass spectrum of the molecular pentaquarks composed of a baryon and a meson. We establish the underlying relations among the near-threshold interactions of the molecular tetraquark and pentaquark systems. We find the existence of the molecule candidates in the $\Sigma_c\bar{D}^{(\ast)}$, $DD^\ast$, and $D\bar{D}^\ast$ systems indicates a substantial presence of the hadronic molecules in the {\it heavy} baryon plus {\it heavy} meson systems ({\it heavy} refers to the hadrons with the $c$ and/or $s$ quarks). We make an exhaustive prediction of the possible bound/virtual molecular states in the systems: $\Sigma_{c}^{(\ast)}\bar{D}^{(\ast)}$, $\Sigma_{c}^{(\ast)}D^{(\ast)}$, $\Xi_{c}^{(\prime,\ast)}\bar{D}^{(\ast)}$, $\Xi_{c}^{(\prime,\ast)}D^{(\ast)}$, $\Sigma_{c}^{(\ast)}K^{\ast}$, $\Sigma_{c}^{(\ast)}\bar{K}^{\ast}$, $\Xi_{c}^{(\prime,\ast)}K^{\ast}$, $\Xi_{c}^{(\prime,\ast)}\bar{K}^{\ast}$, $\Xi_{cc}^{(\ast)}\bar{D}^{(\ast)}$, $\Xi_{cc}^{(\ast)}D^{(\ast)}$, $\Xi_{cc}^{(\ast)}K^{\ast}$, $\Xi_{cc}^{(\ast)}\bar{K}^{\ast}$, $\Sigma^{(\ast)}\bar{D}^{(\ast)}$, $\Sigma^{(\ast)}D^{(\ast)}$, $\Xi^{(\ast)}\bar{D}^{(\ast)}$, $\Xi^{(\ast)}D^{(\ast)}$, $\Sigma^{(\ast)} K^\ast$, $\Sigma^{(\ast)} \bar{K}^\ast$, $\Xi^{(\ast)} K^\ast$, $\Xi^{(\ast)} \bar{K}^\ast$. Hunting for the predicted states in experiments will significantly deepen our understanding of the formation mechanism of the hadronic molecules, and shed light on the manifestation of flavor symmetry in the low-energy residual strong interactions., Comment: 16 pages, 4 figures, and 8 tables

We investigate the tetraquark bound states that are manifestly exotic using three distinct few-body methods: Gaussian Expansion Method (GEM), Resonating Group Method (RGM), and Diffusion Monte Carlo (DMC). We refer to manifestly exotic states that do not involve a mixture with the conventional mesons through the creation and annihilation of $n\bar{n}$, where $n=u, d$. Our calculations are conducted with two types of quark models: the pure constituent quark model featuring one-gluon-exchange interactions and confinement interactions, and the chiral constituent quark model, supplemented by extra one-boson-exchange interactions. This study represents a comprehensive benchmark test of various few-body methods and quark models. Our findings reveal the superiority of GEM over RGM and DMC methods based on present implements for the tetraquark bound states. Additionally, we observe a tendency for the chiral quark model to overestimate the binding energies. We systematically explore the fully, triply, doubly, and singly heavy tetraquark states with $J^P=0^+,1^+,2^+$, encompassing over 150 states in total. We successfully identify several bound states, including $[cc\bar{n}\bar{n}]_{J^{P}=1^{+}}^{I=0}$, $[bb\bar{n}\bar{n}]_{J^{P}=1^{+}}^{I=0}$, $[bc\bar{n}\bar{n}]_{J^{P}=0^{+},1^{+},2^{+}}^{I=0}$, $[bs\bar{n}\bar{n}]_{J^{P}=0^{+},1^{+}}^{I=0}$, $[cs\bar{n}\bar{n}]_{J^{P}=0^{+}}^{I=0}$, and $[bb\bar{n}\bar{s}]_{J^{P}=1^{+}}$, all found to be bound states below the dimeson thresholds., Comment: 15 pages, 7 figures and 5 Tables. Version accepted by PRD

We use the diffusion Monte Carlo method to calculate the doubly heavy tetraquark $T_{cc}$ system in two kinds of constituent quark models, the pure constituent quark model AL1/AP1 and the chiral constituent quark model. When the discrete configurations are complete and no spatial clustering is preseted, the AL1/AP1 model gives an energy of $T_{cc}$ close to the $DD^*$ threshold, and the chiral constituent quark model yields a deeply bound state. We further calculate all doubly heavy tetraquark systems with $J^P=0^+,1^+,2^+$, and provide the binding energies of systems with bound states. The $I(J^P)=0(0^+)$ $bc\bar{n}\bar{n}$, $0(1^+)$ $bb\bar{n}\bar{n}$, $0(1^+)$ $bc\bar{n}\bar{n}$, $\frac{1}{2}(1^+)$ $bb\bar{s}\bar{n}$ systems have bound states in all three models. Since the DMC method has almost no restriction on the spatial part, the resulting bound states have greater binding energies than those obtained in previous works., Comment: 9 pages, 1 figure. Comments are welcomed

We calculate the mass spectrum of the $Qs\bar q \bar q$ $(Q=c, b)$ tetraquark states with $J^P=(0,1,2)^+$ using the AL1 quark potential model, which successfully describes the conventional hadron spectrum. We employ the Gaussian expansion method to solve the four-body Schr\"odinger equation, and use the complex scaling method to identify the resonances. With the notation $T_{Q s, I(J)}^{\text {Theo. }}(M)$, we find several near-threshold bound states and resonances, including $T_{cs,0(0)}^{\mathrm{Theo.}}(2350)$, $T_{cs,0(0)}^{\mathrm{Theo.}}(2906)$, $T_{bs,0(0)}^{\mathrm{Theo.}}(5781)$, $T_{bs,0(1)}^{\mathrm{Theo.}}(5840)$, and $T_{bs,0(0)}^{\mathrm{Theo.}}(6240)$ which are close to the $D\bar{K}$, $D^*\bar{K}^*$, $\bar{B}\bar{K}$, $\bar{B}^*\bar{K}$ and $\bar{B}^*\bar{K}^*$ thresholds, respectively. Furthermore, their spatial structures clearly support their molecular natures. The resonance $T_{cs,0(0)}^{\mathrm{Theo.}}(2906)$ has a mass of $2906$ MeV, a width of $20$ MeV, and quantum numbers $I(J^P)=0(0^+)$, which may serve as a good candidate for the experimental $T_{cs0}(2900)$ state. We strongly urge the experimental search of the predicted states., Comment: 9 pages, 4 figures, 3 tables. Version accepted by PRD

We discuss a novel effective-field-theory-based approach for extracting two-body scattering information from finite volume energies, serving as an alternative to L\"uscher's method. By explicitly incorporating one-pion exchange, we overcome the challenging left-hand cut problem in L\"uscher's method and can handle finite volume energy levels both below and above the left-hand cut. Applied to the lattice data for $DD^*$ scattering at a pion mass of 280 MeV, as an illustrative example, our results reveal the significant impact of the one-pion exchange on P-wave and S-wave phase shifts. The pole position of the $T_{cc}(3875)^+$ state, extracted from the finite-volume energy levels at this pion mass while taking into account left-hand cut effects, range corrections and partial-wave mixing, is consistent with a near-threshold resonance. This study demonstrates, for the first time, that two-body scattering information can be reliably extracted from lattice spectra including the left-hand cut., Comment: 15 pages and 12 figures

We investigate the tetraquark bound states that are manifestly exotic using three distinct few-body methods: Gaussian Expansion Method (GEM), Resonating Group Method (RGM), and Diffusion Monte Carlo (DMC). We refer to manifestly exotic states that do not involve a mixture with the conventional mesons through the creation and annihilation of $n\bar{n}$, where $n=u, d$. Our calculations are conducted with two types of quark models: the pure constituent quark model featuring one-gluon-exchange interactions and confinement interactions, and the chiral constituent quark model, supplemented by extra one-boson-exchange interactions. This study represents a comprehensive benchmark test of various few-body methods and quark models. Our findings reveal the superiority of GEM over RGM and DMC methods based on present implements for the tetraquark bound states. Additionally, we observe a tendency for the chiral quark model to overestimate the binding energies. We systematically explore the fully, triply, doubly, and singly heavy tetraquark states with $J^P=0^+,1^+,2^+$, encompassing over 150 states in total. We successfully identify several bound states, including $[cc\bar{n}\bar{n}]_{J^{P}=1^{+}}^{I=0}$, $[bb\bar{n}\bar{n}]_{J^{P}=1^{+}}^{I=0}$, $[bc\bar{n}\bar{n}]_{J^{P}=0^{+},1^{+},2^{+}}^{I=0}$, $[bs\bar{n}\bar{n}]_{J^{P}=0^{+},1^{+}}^{I=0}$, $[cs\bar{n}\bar{n}]_{J^{P}=0^{+}}^{I=0}$, and $[bb\bar{n}\bar{s}]_{J^{P}=1^{+}}$, all found to be bound states below the dimeson thresholds., Comment: 15 pages, 7 figures and 5 Tables. Version accepted by PRD

We relate the interactions of the $\bar{D}^{(\ast)} K^\ast$ and $D^{(\ast)} K^\ast$ systems to those of $D^{(\ast)}D^{(\ast)}$ and $D^{(\ast)}\bar{D}^{(\ast)}$ respectively, considering the residual strong interactions at the near-threshold energy is too weak to excite the strange quarks inside the hadrons. We propose an effective model to describe the low-energy S-wave interactions that are undertaken by the light $u$, $d$ quarks between two separated heavy hadrons. We find that the existence of molecules in the heavy-(anti)heavy sectors will naturally lead to the emergence of molecular states in $\bar{D}^{(\ast)} K^\ast$ and $D^{(\ast)} K^\ast$ systems. The recently observed $T_{cs0}(2900)$ and $T_{c\bar{s}0}^a(2900)$ can be well identified as the $0(0^+)$ and $1(0^+)$ partners of $T_{cc}(3875)$ and $Z_c(3900)$ in the charmed strange sector, respectively. We also predict their members under the {\it heavy} ($c$ and $s$) quark symmetry and SU(2) flavor symmetry. Most of them are very good molecule candidates, for example, (i) the $0(1^+)$ states in $D^\ast D^\ast$, $\bar{D}K^\ast$, $\bar{D}^\ast K^\ast$; (ii) the $0^{(+)}(2^{+(+)})$ states in $D^\ast \bar{D}^\ast$, $\bar{D}^\ast K^\ast$, $D^\ast K^\ast$; (iii) the $1^-(0^{++})$ state in $D^\ast\bar{D}^\ast$ and $1(1^+)$ state in $D^\ast K^\ast$. The $0^+(0^{++})$ state in $D\bar{D}$ and the $0(1^+)$ state in $DK^\ast$ might also exist as virtual states, and the $0(1^+)$ $DK^\ast$ can serve as a key to infer the existence of $0^+(0^{++})$ $D\bar{D}$. The $D_s\pi$ invariant mass spectrum of $T_{c\bar{s}0}^a(2900)$ is also studied within the coupled-channel approach, and the molecular interpretation of $T_{c\bar{s}0}^a(2900)$ is consistent with the experimental data. Searching for the predicted states in experiments is crucial to discriminate the different pictures for interpreting these near-threshold exotica., Comment: 13 pages, 6 figs, and 4 tables

We use the diffusion Monte Carlo method to calculate the doubly heavy tetraquark $T_{cc}$ system in two kinds of constituent quark models, the pure constituent quark model AL1/AP1 and the chiral constituent quark model. When the discrete configurations are complete and no spatial clustering is preseted, the AL1/AP1 model gives an energy of $T_{cc}$ close to the $DD^*$ threshold, and the chiral constituent quark model yields a deeply bound state. We further calculate all doubly heavy tetraquark systems with $J^P=0^+,1^+,2^+$, and provide the binding energies of systems with bound states. The $I(J^P)=0(0^+)$ $bc\bar{n}\bar{n}$, $0(1^+)$ $bb\bar{n}\bar{n}$, $0(1^+)$ $bc\bar{n}\bar{n}$, $\frac{1}{2}(1^+)$ $bb\bar{s}\bar{n}$ systems have bound states in all three models. Since the DMC method has almost no restriction on the spatial part, the resulting bound states have greater binding energies than those obtained in previous works., Comment: 9 pages, 1 figure. Comments are welcomed

We improve the complex scaling method (CSM) to obtain virtual states, which were previously challenging in the conventional CSM. Our approach solves the Schr\"odinger equation in the momentum space as an eigenvalue problem by choosing the flexible contours. It proves to be highly effective in identifying the poles across the different Riemann sheets in the multichannel scatterings. It is more straightforward and efficient than searching for the zeros of the Fredholm determinant of the Lippmann-Schwinger equation using the root-finding algorithms. This advancement significantly extends the capabilities of the CSM in accurately characterizing the resonances and virtual states in quantum systems., Comment: 12 pages, 14 figures, 2 tables. Version accepted by PRD

Chen-Ye Feng &ast;, Shi-Yao Bai &ast;, Meng-Lu Li, Jie-Yu Zhao, Jia-Min Sun, Hui-Jing Bao, Yuan Ren, Xin-Ming Su Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University; Respiratory Disease Institution of China Medical University, Shenyang, Liaoning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xin-Ming SuDepartment of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University; Respiratory Disease Institution of China Medical University, 155 North Nanjing Street, Shenyang, 110001, Liaoning, People’s Republic of ChinaEmail xinming_med@126.comBackground: Asthma is a chronic inflammatory disease featured by inflammation and remodeling of airway. Adipose-derived mesenchymal stem cell (ADSCs)-derived exosomal miRNAs have been suggested as promising therapeutic manners for diseases.Methods: ADSCs and airway smooth muscle cells (ASMCs) were isolated from SD rats. Flow cytometry was conducted to detect the surface biomarkers of isolated cells. Exosomes were extracted by sequentially centrifuge method and identified by Western blotting and nanoparticle tracking analysis (NTA). Uptake of exosomes by ASMCs was detected by confocal assay. ASMCs were treated with platelet-derived growth factor-BB (PDGF-BB) to mimic cell remodeling and inflammation. Cell counting 8 (CCK-8), Transwell, and flow cytometry were performed to determine the viability, migration, and apoptosis of ASMCs. Release of inflammatory factors was detected by enzyme-linked immunosorbent assay (ELISA). Levels of RNAs and proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay. Interaction between miR-301a-3p and signal transducer and activator of transcription 3 (STAT3) was determined by luciferase reporter gene assay. The effect of Exosomal miR

Chiral symmetry and its spontaneous breaking play an important role both in the light hadron and heavy hadron systems. In this work, we shall review the investigations on the chiral corrections to the properties of the heavy mesons and baryons within the framework of the chiral perturbation theory ($\chi$PT). We will also review the scatterings of the light pseudoscalar mesons and heavy hadrons. Moreover, the modern nuclear force was built upon the chiral effective field theory ($\chi$EFT). In the past decades many new hadron states were observed experimentally. A large group of these states are near-threshold resonances, such as the charged charmoniumlike $Z_c$ and $Z_{cs}$ states, bottomoniumlike $Z_b$ states, hidden-charm pentaquark $P_c$ and $P_{cs}$ states and the doubly charmed $T_{cc}$ state etc. They are very good candidates of the loosely bound molecular states composed of a pair of charmed hadrons. The same chiral dynamics not only governs the nuclei and forms the deuteron, but also dictates the above shallow bound states or resonances. We will perform an extensive review on the progress on the heavy hadronic molecular states within the framework of $\chi$EFT., Comment: A Review on hadronic molecules in EFT frameworks with 168 pages and 67 figures

Chiral symmetry and its spontaneous breaking play an important role both in the light hadron and heavy hadron systems. The chiral perturbation theory ($\chi$PT) is the low energy effective field theory of the QCD. In this work, we shall review the investigations on the chiral corrections to the properties of the heavy mesons and baryons within the framework of $\chi$PT. We will also review the scatterings of the light pseudoscalar mesons and heavy hadrons, through which many new resonances such as the $D_{s0}^\ast(2317)$ could be understood. Moreover, many new hadron states were observed experimentally in the past decades. A large group of these states is near-threshold resonances, such as the charged charmoniumlike $Z_c$ and $Z_{cs}$ states, bottomoniumlike $Z_b$ states, hidden-charm pentaquark $P_c$ and $P_{cs}$ states and the doubly charmed $T_{cc}$ state, etc. They are very good candidates of the loosely bound molecular states composed of a pair of charmed (bottom) hadrons, which are very similar to the loosely bound deuteron. The modern nuclear force was built upon the chiral effective field theory ($\chi$EFT), which is the extension of the $\chi$PT to the systems with two matter fields. The long-range and medium-long-range interactions between two nucleons arise from the single- and double-pion exchange respectively, which are well constrained by the chiral symmetry and its spontaneous breaking. The short-distance interactions can be described by the low energy constants. Such a framework works very well for the nucleon-nucleon scattering and nuclei. In this work, we will perform an extensive review of the progress on the heavy hadronic molecular states within the framework of $\chi$EFT. We shall emphasize that the same chiral dynamics not only govern the nuclei and forms the deuteron, but also dictates the shallow bound states or resonances composed of two heavy hadrons., Comment: A Review on hadronic molecules in EFT frameworks with 178 pages and 69 figures; Accepted version by Physics Reports

We make a systematical diffusion Monte Carlo (DMC) calculation for all ground state baryons in two confinement scenarios, the pairwise confinement and the three-body flux-tube confinement. With the baryons as an example, we illustrate a feasible procedure to investigate the few-quark states with possible few-body confinement mechanisms, which can be extended to the multiquark states easily. For each baryon, we extract the mass, mean-square radius, charge radius, and the quark distributions. We use the Jackknife resampling method to estimate the statistical uncertainties of masses to be less than 1 MeV. To determine the baryon charge radii, we include the constituent quark size effect, which is fixed by the experimental and lattice QCD results. Our results show that both two-body and three-body confinement mechanisms can give a good description of the experimental data if the parameters are chosen properly. In the flux-tube confinement, introducing different tension parameters for the baryons and mesons are necessary, specifically, $\sigma_Y= 0.9204 \sigma_{Q\bar{Q}}$. The lesson from the calculation of the nucleon mass with the DMC method is that the improper pre-assignment of the channels may prevent us from obtaining the real ground state. With this experience, we obtain the real ground state (the $\eta_c \eta_c$ threshold with the di-meson configuration) of the $cc\bar{c}\bar{c}$ system with $J^{PC}=0^{++}$ starting from the diquark-antidiquark spin-color channels alone, which is hard to achieve in the variational method and was not obtained in the previous DMC calculations., Comment: 24 pages, 18 figures. The Supplement material is attached in the source code of LaTeX. Comments are welcomed

We make a systematical diffusion Monte Carlo (DMC) calculation for all ground state baryons in two confinement scenarios, the pairwise confinement and the three-body flux-tube confinement. With the baryons as an example, we illustrate a feasible procedure to investigate the few-quark states with possible few-body confinement mechanisms, which can be extended to the multiquark states easily. For each baryon, we extract the mass, mean-square radius, charge radius, and the quark distributions. We use the Jackknife resampling method to estimate the statistical uncertainties of masses to be less than 1 MeV. To determine the baryon charge radii, we include the constituent quark size effect, which is fixed by the experimental and lattice QCD results. Our results show that both two-body and three-body confinement mechanisms can give a good description of the experimental data if the parameters are chosen properly. In the flux-tube confinement, introducing different tension parameters for the baryons and mesons are necessary, specifically, $\sigma_Y= 0.9204 \sigma_{Q\bar{Q}}$. The lesson from the calculation of the nucleon mass with the DMC method is that the improper pre-assignment of the channels may prevent us from obtaining the real ground state. With this experience, we obtain the real ground state (the $\eta_c \eta_c$ threshold with the di-meson configuration) of the $cc\bar{c}\bar{c}$ system with $J^{PC}=0^{++}$ starting from the diquark-antidiquark spin-color channels alone, which is hard to achieve in the variational method and was not obtained in the previous DMC calculations., Comment: 24 pages, 18 figures. The Supplement material is attached in the source code of LaTeX. Comments are welcomed

We studied the $D\bar{D}^\ast/\bar{D}D^\ast$, $D^\ast\bar{D}^\ast$, $\bar{D}_s D^\ast/\bar{D}_s^\ast D$, $B\bar{B}^\ast/\bar{B}B^\ast$ and $B^\ast\bar{B}^\ast$ di-hadron interactions in chiral effective field theory ($\chi$EFT) up to the next-to-leading (NLO) order. The above-threshold tetraquark states $Z_c(3900)$, $Z_c(4020)$, $Z_{cs}(3985)$, $Z_b(10610)$, $Z_b(10650)$ can be explained as the corresponding di-hadron resonances, respectively. We also studied the $\Sigma_c^{(\ast)}\bar{D}^{(\ast)}$ interactions to investigate the three hidden-charm pentaquarks $P_c(4312)$, $P_c(4440)$ and $P_c(4457)$. We further used the parameters fixed from the $P_c$ states to predict the possible molecular states in $\Xi_c\bar{D}^{(\ast)}$, $\Xi_c^\prime\bar{D}^{(\ast)}$ and $\Xi_c^\ast\bar{D}^{(\ast)}$ systems. Our predictions of the $\Xi_c\bar{D}^{(\ast)}$ bound states are very consistent with two new near-threshold structures recently observed by the LHCb Collaboration., Comment: Talk presented at QCD22, 25th International Conference in QCD (4-7, July, 2022, Montpellier - FR). 4 pages, 5 figs, 1 table

We revisit the $DD^\ast$ interactions in chiral effective field theory up to the third order for the first time. We deal with the pion-exchanged interactions via local momentum-space regularization, in which we focus on their long-range behaviors through demanding their contributions vanish at the origin in the coordinate space. The short-range contact interactions and subleading pion-charmed meson couplings are estimated with the phenomenological resonance saturation model. The subleading pion-charmed meson couplings are much weaker than those in the pion-nucleon system, thus the $DD^\ast$ binding mechanism is very different with that of the $NN$ system. We also obtain the analytic structure of the two-pion exchange interactions in the coordinate space, and we find that its asymptotic behavior at long distance is similar to but slightly different with the $NN$ interactions. We get the same asymptotic behavior of the two-pion exchange interaction with that from HAL QCD method but appearing in the longer distance rather than $1

Very recently, the LHCb Collaboration reported the first observation of the hidden charm pentaquark with strangeness, $P_{\psi s}^\Lambda(4338)^0$. Considering this state is very close to the $\Xi_c^0\bar{D}^0$ and $\Xi_c^+D^-$ thresholds, we explore the possible bias of the Breit-Wigner parameterization, with emphasis on the effect of its coupling to the double thresholds $\Xi_c^0\bar{D}^0$ and $\Xi_c^+D^-$. We first use a qualitative picture based on the ``uniformization" of the Riemann surface of the two-channel system to understand the positions of the enhancement. Then we use the Lippmann-Schwinger equation (LSE) formalism (equivalent to the $K$-matrix parameterization) with two models, the zero-range model and Flatt\'e model to investigate the $J/\psi \Lambda$ lineshapes. Our results show that the nominal peak of the $P_{\psi s}^\Lambda(4338)^0$ could arise either from the pole well above the $\Xi_c^+ D^-$ threshold on the $(-,+)$ sheet or from the pole well below the $\Xi_c^0 \bar{D}^0$ threshold on the $(-,-)$ sheet in the two-channel system. Using the Breit-Wigner distribution to depict the above two lineshapes could be misleading. We also find a novel type of lineshapes with the enhancement constrained by the threshold difference. We urge the LHCb collaboration to perform the refined experimental analysis considering the unitarity and analyticity, e.g. using the K-matrix parameterization. As a by-product, we obtain that the ratio of the isospin violating decay ${\Gamma_{P_{\psi s}^{\Lambda}\to J/\psi\Sigma}}/{\Gamma_{P_{\psi s}^{\Lambda}\to J/\psi\Lambda}}$ could be up to $10\%$., Comment: 15 pages,16 figures. Accepted version by Physical Review D. Adopting the uniformization of the two-channel Riemann surface

We make a systematical diffusion Monte Carlo (DMC) calculation for all ground state baryons in two confinement scenarios, the pairwise confinement and the three-body flux-tube confinement. With the baryons as an example, we illustrate a feasible procedure to investigate the few-quark states with possible few-body confinement mechanisms, which can be extended to the multiquark states easily. For each baryon, we extract the mass, mean-square radius, charge radius, and the quark distributions. We use the Jackknife resampling method to estimate the statistical uncertainties of masses to be less than 1 MeV. To determine the baryon charge radii, we include the constituent quark size effect, which is fixed by the experimental and lattice QCD results. Our results show that both two-body and three-body confinement mechanisms can give a good description of the experimental data if the parameters are chosen properly. In the flux-tube confinement, introducing different tension parameters for the baryons and mesons are necessary, specifically, $\sigma_Y= 0.9204 \sigma_{Q\bar{Q}}$. The lesson from the calculation of the nucleon mass with the DMC method is that the improper pre-assignment of the channels may prevent us from obtaining the real ground state. With this experience, we obtain the real ground state (the $\eta_c \eta_c$ threshold with the di-meson configuration) of the $cc\bar{c}\bar{c}$ system with $J^{PC}=0^{++}$ starting from the diquark-antidiquark spin-color channels alone, which is hard to achieve in the variational method and was not obtained in the previous DMC calculations., Comment: 24 pages, 18 figures. The Supplement material is attached in the source code of LaTeX. Comments are welcomed

We make a systematical diffusion Monte Carlo (DMC) calculation for all ground state baryons in two confinement scenarios, the pairwise confinement and the three-body flux-tube confinement. With the baryons as an example, we illustrate a feasible procedure to investigate the few-quark states with possible few-body confinement mechanisms, which can be extended to the multiquark states easily. For each baryon, we extract the mass, mean-square radius, charge radius, and the quark distributions. We use the Jackknife resampling method to estimate the statistical uncertainties of masses to be less than 1 MeV. To determine the baryon charge radii, we include the constituent quark size effect, which is fixed by the experimental and lattice QCD results. Our results show that both two-body and three-body confinement mechanisms can give a good description of the experimental data if the parameters are chosen properly. In the flux-tube confinement, introducing different tension parameters for the baryons and mesons are necessary, specifically, $\sigma_Y= 0.9204 \sigma_{Q\bar{Q}}$. The lesson from the calculation of the nucleon mass with the DMC method is that the improper pre-assignment of the channels may prevent us from obtaining the real ground state. With this experience, we obtain the real ground state (the $\eta_c \eta_c$ threshold with the di-meson configuration) of the $cc\bar{c}\bar{c}$ system with $J^{PC}=0^{++}$ starting from the diquark-antidiquark spin-color channels alone, which is hard to achieve in the variational method and was not obtained in the previous DMC calculations., Comment: 24 pages, 18 figures. The Supplement material is attached in the source code of LaTeX. Comments are welcomed

Very recently, the LHCb Collaboration reported the first observation of the hidden charm pentaquark with strangeness, $P_{\psi s}^\Lambda(4338)^0$. Considering this state is very close to the $\Xi_c^0\bar{D}^0$ and $\Xi_c^+D^-$ thresholds, we explore the possible bias of the Breit-Wigner parameterization, with emphasis on the effect of its coupling to the double thresholds $\Xi_c^0\bar{D}^0$ and $\Xi_c^+D^-$. We first use a qualitative picture based on the ``uniformization" of the Riemann surface of the two-channel system to understand the positions of the enhancement. Then we use the Lippmann-Schwinger equation (LSE) formalism (equivalent to the $K$-matrix parameterization) with two models, the zero-range model and Flatt\'e model to investigate the $J/\psi \Lambda$ lineshapes. Our results show that the nominal peak of the $P_{\psi s}^\Lambda(4338)^0$ could arise either from the pole well above the $\Xi_c^+ D^-$ threshold on the $(-,+)$ sheet or from the pole well below the $\Xi_c^0 \bar{D}^0$ threshold on the $(-,-)$ sheet in the two-channel system. Using the Breit-Wigner distribution to depict the above two lineshapes could be misleading. We also find a novel type of lineshapes with the enhancement constrained by the threshold difference. We urge the LHCb collaboration to perform the refined experimental analysis considering the unitarity and analyticity, e.g. using the K-matrix parameterization. As a by-product, we obtain that the ratio of the isospin violating decay ${\Gamma_{P_{\psi s}^{\Lambda}\to J/\psi\Sigma}}/{\Gamma_{P_{\psi s}^{\Lambda}\to J/\psi\Lambda}}$ could be up to $10\%$., Comment: 15 pages,16 figures. Accepted version by Physical Review D. Adopting the uniformization of the two-channel Riemann surface

Qian Huang,1,2,&ast; Lu Meng,1,2,&ast; Huilin Li,2 Ni Xiong,1,2 Lin Zeng,1,2 Gaoxiang Wang,2,3 Pengxiang Zhang,1,2 Hengxia Zhao,2 Deliang Liu2 1The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, People’s Republic of China; 2Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People’s Republic of China; 3Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Deliang Liu, Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 1&num; Fuhua Road, Futian District, Shenzhen, 518033, People’s Republic of China, Tel +86 13924610289, Fax +86 755-88358328-3319, Email vinson212@163.comPurpose: As a formula of traditional Chinese medicine (TCM), Huoxue Jiangtang Decoction (HJD) has positive effects on diabetes mellitus (DM) through improving of the metabolism of glycolipid and the function of β-cell. Hence, this research aims to explore the potential therapeutic effects of HJD on diabetes and reveal its underlying mechanisms.Methods: Diabetic rat models induced by high-fat diet (HFD) and streptozotocin (STZ) were included in this study. Following successful modeling, diabetic rats were treated with HJD, and then its therapeutic effects in eight weeks were evaluated. In addition to biochemical indicators, two-bottle preference tests were carried out to examine the rats’ preferences for fat and sugar, and 16S rRNA gene sequencing was performed to disclose the differences of oral microbiota among groups. Finally, Pearson correlation coefficient was used to explore the correlation between oral microbiota and the preferences for fat and sugar.Results: It was found that HJD significantly improved the levels of fasting blood glucose (FBG), glucose tolerance, and dyslipidemia. Additionally, HJD contributed to decreasi

Chen-Ye Feng &ast;, Shi-Yao Bai &ast;, Meng-Lu Li, Jie-Yu Zhao, Jia-Min Sun, Hui-Jing Bao, Yuan Ren, Xin-Ming Su Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University; Respiratory Disease Institution of China Medical University, Shenyang, Liaoning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xin-Ming SuDepartment of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University; Respiratory Disease Institution of China Medical University, 155 North Nanjing Street, Shenyang, 110001, Liaoning, People’s Republic of ChinaEmail xinming_med@126.comBackground: Asthma is a chronic inflammatory disease featured by inflammation and remodeling of airway. Adipose-derived mesenchymal stem cell (ADSCs)-derived exosomal miRNAs have been suggested as promising therapeutic manners for diseases.Methods: ADSCs and airway smooth muscle cells (ASMCs) were isolated from SD rats. Flow cytometry was conducted to detect the surface biomarkers of isolated cells. Exosomes were extracted by sequentially centrifuge method and identified by Western blotting and nanoparticle tracking analysis (NTA). Uptake of exosomes by ASMCs was detected by confocal assay. ASMCs were treated with platelet-derived growth factor-BB (PDGF-BB) to mimic cell remodeling and inflammation. Cell counting 8 (CCK-8), Transwell, and flow cytometry were performed to determine the viability, migration, and apoptosis of ASMCs. Release of inflammatory factors was detected by enzyme-linked immunosorbent assay (ELISA). Levels of RNAs and proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay. Interaction between miR-301a-3p and signal transducer and activator of transcription 3 (STAT3) was determined by luciferase reporter gene assay. The effect of Exosomal miR

Sign language is a beautiful visual language and is also the primary language used by speaking and hearing-impaired people. However, sign language has many complex expressions, which are difficult for the public to understand and master. Sign language recognition algorithms will significantly facilitate communication between hearing-impaired people and normal people. Traditional continuous sign language recognition often uses a sequence learning method based on Convolutional Neural Network (CNN) and Long Short-Term Memory Network (LSTM). These methods can only learn spatial and temporal features separately, which cannot learn the complex spatial-temporal features of sign language. LSTM is also difficult to learn long-term dependencies. To alleviate these problems, this paper proposes a multi-view spatial-temporal continuous sign language recognition network. The network consists of three parts. The first part is a Multi-View Spatial-Temporal Feature Extractor Network (MSTN), which can directly extract the spatial-temporal features of RGB and skeleton data; the second is a sign language encoder network based on Transformer, which can learn long-term dependencies; the third is a Connectionist Temporal Classification (CTC) decoder network, which is used to predict the whole meaning of the continuous sign language. Our algorithm is tested on two public sign language datasets SLR-100 and PHOENIX-Weather 2014T (RWTH). As a result, our method achieves excellent performance on both datasets. The word error rate on the SLR-100 dataset is 1.9%, and the word error rate on the RWTHPHOENIX-Weather dataset is 22.8%., Comment: 12 pages, 4 figures

Chiral symmetry and its spontaneous breaking play an important role both in the light hadron and heavy hadron systems. The chiral perturbation theory ($\chi$PT) is the low energy effective field theory of the QCD. In this work, we shall review the investigations on the chiral corrections to the properties of the heavy mesons and baryons within the framework of $\chi$PT. We will also review the scatterings of the light pseudoscalar mesons and heavy hadrons, through which many new resonances such as the $D_{s0}^\ast(2317)$ could be understood. Moreover, many new hadron states were observed experimentally in the past decades. A large group of these states is near-threshold resonances, such as the charged charmoniumlike $Z_c$ and $Z_{cs}$ states, bottomoniumlike $Z_b$ states, hidden-charm pentaquark $P_c$ and $P_{cs}$ states and the doubly charmed $T_{cc}$ state, etc. They are very good candidates of the loosely bound molecular states composed of a pair of charmed (bottom) hadrons, which are very similar to the loosely bound deuteron. The modern nuclear force was built upon the chiral effective field theory ($\chi$EFT), which is the extension of the $\chi$PT to the systems with two matter fields. The long-range and medium-long-range interactions between two nucleons arise from the single- and double-pion exchange respectively, which are well constrained by the chiral symmetry and its spontaneous breaking. The short-distance interactions can be described by the low energy constants. Such a framework works very well for the nucleon-nucleon scattering and nuclei. In this work, we will perform an extensive review of the progress on the heavy hadronic molecular states within the framework of $\chi$EFT. We shall emphasize that the same chiral dynamics not only govern the nuclei and forms the deuteron, but also dictates the shallow bound states or resonances composed of two heavy hadrons., Comment: A Review on hadronic molecules in EFT frameworks with 178 pages and 69 figures; Accepted version by Physics Reports

In autumn 2021, the largest volcanic eruption on the island of La Palma in historic records took place. The Canary Islands are of volcanic origin and eruptions have always constituted part of their natural disturbance regime. Until recently, their impacts could not be directly observed and studied. Influence of the emission of phytotoxic gases on biodiversity and ecosystem dynamics was hitherto unknown. The recent eruption is still being intensely monitored. We used Sentinel-2 remote sensing data to analyze the spatial extent and intensity of the impact related to sulfuric emissions, aiming to understand the damage patterns in Canary pine forest. The emissions damaged 10% of that forest and affected 5.3% of the Natura 2000 protected areas. We concluded that this is largely due to the toxic effects of the enormous emissions of SO2. We found a clear correlation between the change in the normalized difference vegetation index (NDVI) and distance from the eruption. This pattern was weakly anisotropic, with stronger damage in southern directions. Counteracting effects, such as ash deposition, were largely excluded by combining NDVI change detection with tree cover density. We expect that vegetation damage will be transient. P. canariensis can resprout after forest fires, where most leaves are lost. Consequently, our assessment can serve as a reference for future ecosystem regeneration.

Restricting the aggregation and rationally adjusting the electronic structure of binary metal centers in metal-organic framework (MOF) precursors are important for optimizing their performance as electrocatalysts for the oxygen evolution reaction (OER) and achieving low overpotential and high stability in such applications. Herein, we demonstrate the possibility of enhancing the electrochemical activity of MOF-derived binary metal center catalysts by controlling the form of the Fe species. The introduction of Fe-SBU (iron 2,5-dihydroxyterephthalic acid) into ZIF-67 is found to induce a distinct confinement effect and this can be exploited to improve the electroconductivity of binary metal center catalysts, and therefore, to reduce the OER reaction barrier (OOH∗ → O∗). When applied as an OER catalyst in 1 M KOH solution, the Fe-SBU@Co-Matrix catalyst exhibits a low overpotential of 249 mV to reach a current density of 10 mA cm-2 and high stability for over 40 h. This work describes the secondary growth treatment of MOF-derived porous carbons to promote their application as catalysts in energy conversion reactions. This journal is

In this work, we revisit the isospin violating decays of $X(3872)$ in a coupled-channel effective field theory. In the molecular scheme, the $X(3872)$ is interpreted as the bound state of $\bar{D}^{*0}D^0/\bar{D}^0D^{*0}$ and $D^{*-}D^+/D^-D^{*+}$ channels. In a cutoff-independent formalism, we relate the coupling constants of $X(3872)$ with the two channels to the molecular wave function. The isospin violating decays of $X(3872)$ are obtained by two equivalent approaches, which amend some deficiencies about this issue in literature. In the quantum field theory approach, the isospin violating decays arise from the coupling constants of $X(3872)$ to two di-meson channels. In the quantum mechanics approach, the isospin violating is attributed to wave functions at the origin. We illustrate that how to cure the insufficient results in literature. Within the comprehensive analysis, we bridge the isospin violating decays of $X(3872)$ to its inner structure. Our results show that the proportion of the neutral channel in $X(3872)$ is over $80\%$. As a by-product, we calculate the strong decay width of $X(3872)\to \bar{D}^0 D^0\pi^0$ and radiative one $X(3872)\to \bar{D}^0 D^0\gamma$. The strong decay width and radiative decay width are about 30 keV and 10 keV, respectively, for the binding energy from $-300$ keV to $-50$ keV., Comment: 8 pages, 4 figures. Accepted version by Physical Review D

We propose an alternative approach to L\"uscher's formula for extracting two-body scattering phase shifts from finite volume spectra with no reliance on the partial wave expansion. We use an effective-field-theory-based Hamiltonian method in the plane wave basis and decompose the corresponding matrix elements of operators into irreducible representations of the relevant point groups. The proposed approach allows one to benefit from the knowledge of the long-range interaction and avoids complications from partial wave mixing in a finite volume. We consider spin-singlet channels in the two-nucleon system and pion-pion scattering in the $\rho$-meson channel in the rest and moving frames to illustrate the method for non-relativistic and relativistic systems, respectively. For the two-nucleon system, the long-range interaction due to the one-pion exchange is found to make the single-channel L\"uscher formula unreliable at the physical pion mass. For S-wave dominated states, the single-channel L\"uscher method suffers from significant finite-volume artifacts for a $L=3$~fm box, but it works well for boxes with $L>5$~fm. However, for P-wave dominated states, significant partial wave mixing effects prevent the application of the single-channel L\"uscher formula regardless of the box size (except for the near-threshold region). Using a toy model to generate synthetic data for finite-volume energies, we show that our effective-field-theory-based approach in the plane wave basis is capable of a reliable extraction of the phase shifts. For pion-pion scattering, we employ a phenomenological model to fit lattice QCD results at the physical pion mass. The extracted P-wave phase shifts are found to be in a good agreement with the experimental results., Comment: 40 pages, 14 figures,12 tables. Accepted version by JHEP

Recently, the hidden charm tetraquark states $Z_{cs}(3985)$ and $Z_{cs}(4000)$ with strangeness were observed by the BESIII and LHCb collaborations, respectively, which are great breakthroughs for exploring exotic QCD structures. The first and foremost question is whether they are the same state. In this work, we explore the implications of the narrower state $Z_{cs}(3985)$ in BESIII and the wider one $Z_{cs}(4000)$ in LHCb as two different states. Within a solvable nonrelativistic effective field theory, we include the possible violations of heavy quark spin symmetry and SU(3) flavor symmetry in a comprehensive approach. If $Z_{cs}(3985)$ and $Z_{cs}(4000)$ are two different states, our results show that $Z_{cs}(4000)/Z_{cs}(3985)$ is the pure $(|\bar{D}_s^*D\rangle+/- |\bar{D}_sD^*\rangle)/\sqrt{2}$ state, and the SU(3) flavor partner of $Z_{c}(3900)$ is $Z_{cs}(4000)$ rather than the $Z_{cs}(3985)$. Another two important consequences are the existence of a tensor $\bar{D}_s^*D^*$ resonance with mass about 4126 MeV and width 13 MeV, and the suppression of the decay mode $Z_{cs}(3985) \to J/\psi K$. The two consequences can be tested in experiments and distinguish the two-state interpretation from the one-state scheme., Comment: 8 pages,3 figures and 1 table; Accepted version by Science Bulletin

In this work, we revisit the isospin violating decays of $X(3872)$ in a coupled-channel effective field theory. In the molecular scheme, the $X(3872)$ is interpreted as the bound state of $\bar{D}^{*0}D^0/\bar{D}^0D^{*0}$ and $D^{*-}D^+/D^-D^{*+}$ channels. In a cutoff-independent formalism, we relate the coupling constants of $X(3872)$ with the two channels to the molecular wave function. The isospin violating decays of $X(3872)$ are obtained by two equivalent approaches, which amend some deficiencies about this issue in literature. In the quantum field theory approach, the isospin violating decays arise from the coupling constants of $X(3872)$ to two di-meson channels. In the quantum mechanics approach, the isospin violating is attributed to wave functions at the origin. We illustrate that how to cure the insufficient results in literature. Within the comprehensive analysis, we bridge the isospin violating decays of $X(3872)$ to its inner structure. Our results show that the proportion of the neutral channel in $X(3872)$ is over $80\%$. As a by-product, we calculate the strong decay width of $X(3872)\to \bar{D}^0 D^0\pi^0$ and radiative one $X(3872)\to \bar{D}^0 D^0\gamma$. The strong decay width and radiative decay width are about 30 keV and 10 keV, respectively, for the binding energy from $-300$ keV to $-50$ keV., Comment: 8 pages, 4 figures. Accepted version by Physical Review D

We propose an alternative approach to L\"uscher's formula for extracting two-body scattering phase shifts from finite volume spectra with no reliance on the partial wave expansion. We use an effective-field-theory-based Hamiltonian method in the plane wave basis and decompose the corresponding matrix elements of operators into irreducible representations of the relevant point groups. The proposed approach allows one to benefit from the knowledge of the long-range interaction and avoids complications from partial wave mixing in a finite volume. We consider spin-singlet channels in the two-nucleon system and pion-pion scattering in the $\rho$-meson channel in the rest and moving frames to illustrate the method for non-relativistic and relativistic systems, respectively. For the two-nucleon system, the long-range interaction due to the one-pion exchange is found to make the single-channel L\"uscher formula unreliable at the physical pion mass. For S-wave dominated states, the single-channel L\"uscher method suffers from significant finite-volume artifacts for a $L=3$~fm box, but it works well for boxes with $L>5$~fm. However, for P-wave dominated states, significant partial wave mixing effects prevent the application of the single-channel L\"uscher formula regardless of the box size (except for the near-threshold region). Using a toy model to generate synthetic data for finite-volume energies, we show that our effective-field-theory-based approach in the plane wave basis is capable of a reliable extraction of the phase shifts. For pion-pion scattering, we employ a phenomenological model to fit lattice QCD results at the physical pion mass. The extracted P-wave phase shifts are found to be in a good agreement with the experimental results., Comment: 40 pages, 14 figures,12 tables. Accepted version by JHEP

With a quark level interaction, we give a unified description of the loosely bound molecular systems composed of the heavy flavor hadrons $(\bar{D},\bar{D}^*)$, $(\Lambda_c, \Sigma_c, \Sigma_c^*)$, and $(\Xi_c, \Xi_c^\prime,\Xi_c^*)$. Using the $P_c$ states as inputs to fix the interaction strength of light quark-quark pairs, we reproduce the observed $P_{cs}$ and $T_{cc}^+$ states and predict another narrow $T_{cc}^{\prime+}$ state with quantum numbers $[D^*D^*]_{J=1}^{I=0}$. If we require a satisfactory description of the $T_{cc}^+$ and $P_c$ states simultaneously, our framework prefers the assignments of the $P_{c}(4440)$ and $P_{c}(4457)$ as the $[\Sigma_c\bar{D}^*]_{J=1/2}^{I=1/2}$ and $[\Sigma_c\bar{D}^*]_{J=3/2}^{I=1/2}$ states, respectively. We propose the isospin criterion to explain naturally why the experimentally observed $T_{cc}$, $P_c$, and $P_{cs}$ molecular candidates prefer the lowest isospin numbers. We also predict the loosely bound states for the bottom di-hadrons., Comment: 7 pages, 5 tables, 1 figure

In this work, we revisit the isospin violating decays of $X(3872)$ in a coupled-channel effective field theory. In the molecular scheme, the $X(3872)$ is interpreted as the bound state of $\bar{D}^{*0}D^0/\bar{D}^0D^{*0}$ and $D^{*-}D^+/D^-D^{*+}$ channels. In a cutoff-independent formalism, we relate the coupling constants of $X(3872)$ with the two channels to the molecular wave function. The isospin violating decays of $X(3872)$ are obtained by two equivalent approaches, which amend some deficiencies about this issue in literature. In the quantum field theory approach, the isospin violating decays arise from the coupling constants of $X(3872)$ to two di-meson channels. In the quantum mechanics approach, the isospin violating is attributed to wave functions at the origin. We illustrate that how to cure the insufficient results in literature. Within the comprehensive analysis, we bridge the isospin violating decays of $X(3872)$ to its inner structure. Our results show that the proportion of the neutral channel in $X(3872)$ is over $80\%$. As a by-product, we calculate the strong decay width of $X(3872)\to \bar{D}^0 D^0\pi^0$ and radiative one $X(3872)\to \bar{D}^0 D^0\gamma$. The strong decay width and radiative decay width are about 30 keV and 10 keV, respectively, for the binding energy from $-300$ keV to $-50$ keV., Comment: 8 pages, 4 figures. Accepted version by Physical Review D

Very recently, the LHCb Collaboration reported the doubly charmed tetraquark state $T_{cc}^+$ below the $D^{*+}D^0$ threshold about $273$ keV. As a very near-threshold state, its long-distance structure is very important. In the molecular scheme, we relate the coupling constants of $T_{cc}^+$ with $D^{*0}D^+$ and $D^{*+}D^0$ to its binding energy and mixing angle of two components with a coupled-channel effective field theory. With the coupling constants, we investigate the kinetically allowed strong decays $T_{cc}^+\to D^0D^0\pi^+$, $T_{cc}^+\to D^+D^0\pi^0$ and radiative decays $D^+D^0 \gamma$. Our results show that the decay width of $T_{cc}^+\to D^0D^0\pi^+$ is the largest one, which is just the experimental observation channel. Our theoretical total strong and radiative widths are in favor of the $T_{cc}^+$ as a $|D^{*+}D^0\rangle$ dominated bound state. The total strong and radiative width in the single channel limit and isospin singlet limit are given as $59.7^{+4.6}_{-4.4} \text{ keV}$ and $46.7^{+2.7}_{-2.9} \text{ keV}$, respectively. Our calculation is cutoff-independent and without prior isospin assignment. The absolute partial widths and ratios of the different decay channels can be used to test the structure of $T_{cc}^+$ state when the updated experimental results are available., Comment: 7 pages, 4 figures; Accepted version by Letter in Physical Review D

We systematically calculate the mass spectrum of the higher excited fully-charmed tetraquark $cc\bar c\bar c$ states including the S-wave radial excitations and the P-wave states with a nonrelativistic quark model. The quark model is composed of a vector one-gluon-exchange (OGE) and a scalar linear confinement interaction with the parameters determined by the charmonium spectrum. In the calculation, we consider both the $3_c-\bar 3_c$ and the $6_c-\bar{6}_c$ color representations. For the $cc\bar c\bar c $ state, the $6_c-\bar 6_c$ component is located lower than the $\bar 3_c-3_c$ one because of the stronger attractive interactions between the diquark and antidiquark. We focus on two excited modes and their properties for the P-wave tetraquarks. The mass splitting for the $\rho$-mode excitations with different color configurations is large. The low-lying $6_c-\bar 6_c$ $\rho$-mode component helps to explain the small mass gap between the ground S-wave and the P-wave tetraquark states. The recently observed $X(6900)$ state may be the candidate of the first radially excited tetraquarks with $J^{PC}=0^{++}$ or $2^{++}$, or the $1^{+-}$ or $2^{-+}$ P-wave states based on the mass spectrum. Moreover, the lowest $T_c$ states with the exotic $J^{PC}$ quantum numbers $0^{--}$ and $1^{-+}$ may decay into the P-wave $\eta_c J/\psi$ and di-$J/\psi$ modes, respectively. The future experimental search of these $T_c$ states will enrich the hadronic spectrum., Comment: 15 pages, 3 figures. Version published in PRD

Recently, the hidden charm tetraquark states $Z_{cs}(3985)$ and $Z_{cs}(4000)$ with strangeness were observed by the BESIII and LHCb collaborations, respectively, which are great breakthroughs for exploring exotic QCD structures. The first and foremost question is whether they are the same state. In this work, we explore the implications of the narrower state $Z_{cs}(3985)$ in BESIII and the wider one $Z_{cs}(4000)$ in LHCb as two different states. Within a solvable nonrelativistic effective field theory, we include the possible violations of heavy quark spin symmetry and SU(3) flavor symmetry in a comprehensive approach. If $Z_{cs}(3985)$ and $Z_{cs}(4000)$ are two different states, our results show that $Z_{cs}(4000)/Z_{cs}(3985)$ is the pure $(|\bar{D}_s^*D\rangle+/- |\bar{D}_sD^*\rangle)/\sqrt{2}$ state, and the SU(3) flavor partner of $Z_{c}(3900)$ is $Z_{cs}(4000)$ rather than the $Z_{cs}(3985)$. Another two important consequences are the existence of a tensor $\bar{D}_s^*D^*$ resonance with mass about 4126 MeV and width 13 MeV, and the suppression of the decay mode $Z_{cs}(3985) \to J/\psi K$. The two consequences can be tested in experiments and distinguish the two-state interpretation from the one-state scheme., Comment: 8 pages,3 figures and 1 table; Accepted version by Science Bulletin