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29 results on '"Mendichovszky, Iosif A."'

1. Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Author

Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., Prasad, Pottumarthi V., Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., and Prasad, Pottumarthi V.

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as >= 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020
Full Text
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2. Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Author

Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., Prasad, Pottumarthi V., Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., and Prasad, Pottumarthi V.

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as >= 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020
Full Text
View/download PDF

3. Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Author

Bane, Octavia, Bane, Octavia, Mendichovszky, Iosif A, Milani, Bastien, Dekkers, Ilona A, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O, Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J, Serafin, Zbigniew, Zhang, Jeff L, Francis, Susan T, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B, Prasad, Pottumarthi V, Bane, Octavia, Bane, Octavia, Mendichovszky, Iosif A, Milani, Bastien, Dekkers, Ilona A, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O, Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J, Serafin, Zbigniew, Zhang, Jeff L, Francis, Susan T, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B, and Prasad, Pottumarthi V

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020

4. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Author

Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Abstract

ObjectivesStandardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.Materials and methodsReported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.ResultsCorrelations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.DiscussionThe consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Published
2020

5. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Author

Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Abstract

The article Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Published
2020

6. Correction to : Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

7. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

8. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

9. Correction to : Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

10. Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Author

Bane, Octavia, Bane, Octavia, Mendichovszky, Iosif A, Milani, Bastien, Dekkers, Ilona A, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O, Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J, Serafin, Zbigniew, Zhang, Jeff L, Francis, Susan T, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B, Prasad, Pottumarthi V, Bane, Octavia, Bane, Octavia, Mendichovszky, Iosif A, Milani, Bastien, Dekkers, Ilona A, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O, Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J, Serafin, Zbigniew, Zhang, Jeff L, Francis, Susan T, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B, and Prasad, Pottumarthi V

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020

11. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Author

Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Abstract

ObjectivesStandardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.Materials and methodsReported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.ResultsCorrelations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.DiscussionThe consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Published
2020

12. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Author

Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Abstract

The article Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Published
2020

13. Correction to : Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

14. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

15. Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Author

Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., Prasad, Pottumarthi V., Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., and Prasad, Pottumarthi V.

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as >= 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020
Full Text
View/download PDF

16. Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Author

Bane, Octavia, Bane, Octavia, Mendichovszky, Iosif, Milani, Bastien, Dekkers, Ilona, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Serafin, Zbigniew, Zhang, Jeff, Francis, Susan, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean, Prasad, Pottumarthi, Wang, Zhen, Liu, Chunlei, Bane, Octavia, Bane, Octavia, Mendichovszky, Iosif, Milani, Bastien, Dekkers, Ilona, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Serafin, Zbigniew, Zhang, Jeff, Francis, Susan, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean, Prasad, Pottumarthi, Wang, Zhen, and Liu, Chunlei

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020

17. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

18. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

19. Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Author

Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., Prasad, Pottumarthi V., Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., and Prasad, Pottumarthi V.

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as >= 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020
Full Text
View/download PDF

20. Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Author

Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., Prasad, Pottumarthi V., Bane, Octavia, Mendichovszky, Iosif A., Milani, Bastien, Dekkers, Ilona A., Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E., Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O., Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A., Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J., Serafin, Zbigniew, Zhang, Jeff L., Francis, Susan T., Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B., and Prasad, Pottumarthi V.

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as >= 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020
Full Text
View/download PDF

21. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation : a statement paper and systematic review

Author

Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, Prasad, Pottumarthi Vara, Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, and Prasad, Pottumarthi Vara

Abstract

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Published
2018
Full Text
View/download PDF

22. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation : a statement paper and systematic review

Author

Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, Prasad, Pottumarthi Vara, Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, and Prasad, Pottumarthi Vara

Abstract

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Published
2018
Full Text
View/download PDF

23. Magnetic resonance imaging biomarkers for chronic kidney disease : a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

Author

Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, Sourbron, Steven, Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, and Sourbron, Steven

Published
2018

24. Magnetic resonance imaging biomarkers for chronic kidney disease : a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

Author

Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, Sourbron, Steven, Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, and Sourbron, Steven

Published
2018

25. Magnetic resonance imaging biomarkers for chronic kidney disease : a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

Author

Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, Sourbron, Steven, Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, and Sourbron, Steven

Published
2018

26. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation : a statement paper and systematic review

Author

Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, Prasad, Pottumarthi Vara, Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, and Prasad, Pottumarthi Vara

Abstract

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Published
2018
Full Text
View/download PDF

27. Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

Author

MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, Sourbron, Steven, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Selby, Nicholas M., Blankestijn, Peter J., Boor, Peter, Combe, Christian, Eckardt, Kai Uwe, Eikefjord, Eli, Garcia-Fernandez, Nuria, Golay, Xavier, Gordon, Isky, Grenier, Nicolas, Hockings, Paul D., Jensen, Jens D., Joles, Jaap A., Kalra, Philip A., Krämer, Bernhard K., Mark, Patrick B., Mendichovszky, Iosif A., Nikolic, Olivera, Odudu, Aghogho, Ong, Albert C.M., Ortiz, Alberto, Pruijm, Menno, Remuzzi, Giuseppe, Rørvik, Jarle, de Seigneux, Sophie, Simms, Roslyn J., Slatinska, Janka, Summers, Paul, Taal, Maarten W., Thoeny, Harriet C., Vallée, Jean Paul, Wolf, Marcos, Caroli, Anna, and Sourbron, Steven

Published
2018

28. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation : a statement paper and systematic review

Author

Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, Prasad, Pottumarthi Vara, Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, and Prasad, Pottumarthi Vara

Abstract

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Published
2018
Full Text
View/download PDF

29. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation : a statement paper and systematic review

Author

Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, Prasad, Pottumarthi Vara, Pruijm, Menno, Mendichovszky, Iosif A., Liss, Per, Van der Niepen, Patricia, Textor, Stephen C., Lerman, Lilach O., Krediet, C. T. Paul, Caroli, Anna, Burnier, Michel, and Prasad, Pottumarthi Vara

Abstract

Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.

Published
2018
Full Text
View/download PDF

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