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Purpose – Mental Health Champions (MHCs) and Young Health Ambassadors (YHAs) are two innovative public health interventions. MHCs are practitioners who work in schools and other youth settings and aim to be the ‘go to’ person for mental health in these settings. YHAs are a linked parallel network of young people, who champion mental health and advocate for youth involvement, which was co-produced with young people across all stages of development implementation. This paper aims to identify the potential benefits, barriers, and facilitators of these interventions. Methodology – Semi-structured qualitative interviews (n=19) were undertaken with a purposive sample of n=13 MHCs, and n=6 YHAs, between June 2021 and March 2022. Interviews were audio-recorded, transcribed, anonymised, and then analysed following a thematic approach. Ethical approval was granted by Newcastle University’s Faculty of Medical Sciences Ethics Committee. Findings – Our findings are organised under five key themes: 1) Motivating factors and rewards for MHCs and YHAs; 2) Outcomes for CYP and others; 3) Impact on youth settings and culture; 4) Facilitators of successful implementation; and 5) Implementation challenges and opportunities. Originality – The interventions reported on in the present paper are novel and innovative. Little research has previously been undertaken in order to explore similar approaches, and the individual experiences of those involved in the delivery of these types of interventions. Practical Implications – These findings are intended to be of relevance to practice and policy, particularly to those exploring the design, commissioning, or implementation of similar novel and low-cost interventions, which aim improve mental health outcomes for children and young people, within the context of youth settings.

This study explores how high-growth entrepreneurs use well-being and emotional labour as tools to respond to crises. Drawing on 173 longitudinal interviews with 57 high-growth entrepreneurs during the Covid-19 crisis, we explore internal crisis response strategies. The data show that entrepreneurs employ a variety of emotional labour practices which produce organizational resilience. However, these practices are in tension with the strategic practices required for economic resilience. We show how the emotional of entrepreneurs serves as part of their crisis leadership strategy. This adds a new perspective to the literature on entrepreneurial crisis and resilience by showing the complexity of internal reactions to sudden and prolonged shocks.

Background: Within the current context of continued austerity and post pandemic recovery, it remains important that Local Government services address the increasing needs of residents as cost-effectively as possible. Alliancing, whereby services work collaboratively focusing on the ‘whole-system’, has gained popularity as a tool with the potential to support collaborative whole systems approaches. This synthesis aims to identify how alliancing can be successfully operationalised in the commissioning of public health, wider NHS, and social care related services. Methods: A realist literature synthesis was undertaken in order to identify underlying generative mechanisms associated with alliancing, the contextual conditions surrounding the implementation and operationalisation of the alliancing approach mechanisms, and the outcomes produced as a result. An iterative approach was taken, using a recent systematic review of the effectiveness of Alliancing, online database searches, and grey literature searches. Results: Three mechanistic components were identified within the data as being core to the successful implementation of alliances in public health and social care related services within Local Government: (1) Achieving a system level approach; (2) placing local populations at the heart of the system; and (3) creating a cultural shift. Programme theories were postulated within these components. Conclusions: The alliancing approach offers an opportunity to achieve system-level change with the potential to benefit local populations. The realist synthesis approach taken within this study has provided insights into the necessary contextual and mechanistic factors of the Alliancing approach, above and beyond effectiveness outcomes typically collected through more conventional evaluation methodologies.

FRB 20210912A is a fast radio burst (FRB), detected and localised to sub-arcsecond precision by the Australian Square Kilometre Array Pathfinder. No host galaxy has been identified for this burst despite the high precision of its localisation and deep optical and infrared follow-up, to 5-$\sigma$ limits of $R=26.7$ mag and $K_\mathrm{s}=24.9$ mag with the Very Large Telescope. The combination of precise radio localisation and deep optical imaging has almost always resulted in the secure identification of a host galaxy, and this is the first case in which the line-of-sight is not obscured by the Galactic disk. The dispersion measure of this burst, $\mathrm{DM_{FRB}}=1233.696\pm0.006~\mathrm{pc}\ \mathrm{cm}^{-3}$, allows for a large source redshift of $z>1$ according to the Macquart relation. It could thus be that the host galaxy is consistent with the known population of FRB hosts, but is too distant to detect in our observations ($z>0.7$ for a host like that of the first repeating FRB source, FRB 20121102A); that it is more nearby with a significant excess in $\mathrm{DM_{host}}$, and thus dimmer than any known FRB host; or, least likely, that the FRB is truly hostless. We consider each possibility, making use of the population of known FRB hosts to frame each scenario. The fact of the missing host has ramifications for the FRB field: even with high-precision localisation and deep follow-up, some FRB hosts may be difficult to detect, with more distant hosts being the less likely to be found. This has implications for FRB cosmology, in which high-redshift detections are valuable., Comment: 14 pages, 6 figures. Revised based on referee's comments and accepted to MNRAS

Temporal broadening is a commonly observed property of fast radio bursts (FRBs), associated with turbulent media which cause radiowave scattering. Similarly to dispersion, scattering is an important probe of the media along the line of sight to an FRB source, such as the circum-burst or circum-galactic mediums (CGM). Measurements of characteristic scattering times alone are insufficient to constrain the position of the dominant scattering media along the line of sight. However, where more than one scattering screen exists, Galactic scintillation can be leveraged to form strong constraints. We quantify the scattering and scintillation in 10 FRBs with 1) known host galaxies and redshifts and 2) captured voltage data enabling high-time resolution analysis. We find strong evidence for two screens in three cases. For FRBs 20190608B and 20210320C, we find evidence for scattering screens less than approximately 16.7 and 3000 kpc respectively, from their sources, consistent with the scattering occurring in the circum-burst environment, the host ISM (inter-stellar medium) or the CGM. For FRB 20201124A we find a low modulation index that evolves over the burst's scattering tail, indicating the presence of a scattering screen $\approx9$ kpc from the host, and excluding the circum-burst environment from potential scattering sites. By assuming that pulse broadening is contributed by the host galaxy ISM or circum-burst environment, the lack of observed scintillation in four FRBs in our sample suggests that existing models may be poor estimators of scattering times associated with the Milky Way's ISM, similar to the anomalously low scattering observed for FRB 20201124A., Comment: 13 pages, 9 figures, 1 table. Accepted in MNRAS

From gentle beach waves to violent gamma-ray bursts all transient signals are shaped by the environments through which they propagate. By understanding these propagation effects, we can use observed transients to infer properties about environments that are impossible to observe directly. Using fast radio bursts, this thesis develops our understanding of gravitational lensing and plasma scattering, as ways to constrain the identity of dark matter, and the turbulence of extragalactic material.

A dataset to describe exposed bedrock and surficial geology of Antarctica has been constructed by the GeoMAP Action Group of the Scientific Committee on Antarctic Research (SCAR) and GNS Science. Our group captured existing geological map data into a geographic information system (GIS), refined its spatial reliability, harmonised classification, and improved representation of glacial sequences and geomorphology, thereby creating a comprehensive and coherent representation of Antarctic geology. A total of 99,080 polygons were unified for depicting geology at 1:250,000 scale, but locally there are some areas with higher spatial resolution. Geological unit definition is based on a mixed chronostratigraphic- and lithostratigraphic-based classification. Description of rock and moraine polygons employs the international Geoscience Markup Language (GeoSciML) data protocols to provide attribute-rich and queryable information, including bibliographic links to 589 source maps and scientific literature. GeoMAP is the first detailed geological map dataset covering all of Antarctica. It depicts ‘known geology’ of rock exposures rather than ‘interpreted’ sub-ice features and is suitable for continent-wide perspectives and cross-discipline interrogation.

Background: Despite growing enthusiasm for co-production in healthcare services and research, research on co-production practices is lacking. Multiple frameworks, guidelines and principles are available but little empirical research is conducted on ‘how to do’ co-production of research to improve healthcare services. This paper brings together insights from UK-based collaborative research partnerships on leading co-production. Its aim is to inform practical guidance for new partnerships planning to facilitate the co-production of applied health research in the future. Methods: Using an auto-ethnographic approach, experiential evidence was elicited through collective sense making from recorded conversations between the research team and senior leaders of five UK-based collaborative research partnerships. This approach applies a cultural analysis and interpretation of the leaders’ behaviours, thoughts and experiences of co-production taking place in 2008–2018 and involving academics, health practitioners, policy makers and representatives of third sector organisations. Results: The findings highlight a variety of practices across CLAHRCs, whereby the intersection between the senior leaders’ vision and local organisational context in which co-production occurs largely determines the nature of co-production process and outcomes. We identified four tensions in doing co-production: (1) idealistic, tokenistic vs realistic narratives, (2) power differences and (lack of) reciprocity, (3) excluding vs including language and communication, (4) individual motivation vs structural issues. Conclusions: The tensions were productive in helping collaborative research partnerships to tailor co-production practices to their local needs and opportunities. Resulting variation in co-production practices across partnerships can therefore be seen as highly advantageous creative adaptation, which makes us question the utility of seeking a unified ‘gold standard’ of co-production. Strategic

After more than five years of development, we present a new version of Dark Sage, a semi-analytic model (SAM) of galaxy formation that breaks the mould for models of its kind. Included among the major changes is an overhauled treatment of stellar feedback that is derived from energy conservation, operates on local scales, affects gas gradually over time rather than instantaneously, and predicts a mass-loading factor for every galaxy. Building on the model's resolved angular-momentum structure of galaxies, we now consider the heating of stellar discs, delivering predictions for disc structure both radially and vertically. We add a further dimension to stellar discs by tracking the distribution of stellar ages in each annulus. Each annulus--age bin has its own velocity dispersion and metallicity evolved in the model. This allows Dark Sage to make structural predictions for galaxies that previously only hydrodynamic simulations could. We present the model as run on the merger trees of the highest-resolution gravity-only simulation of the MillenniumTNG suite. Despite its additional complexity relative to other SAMs, Dark Sage only has three free parameters, the least of any SAM, which we calibrate exclusively against the cosmic star formation history and the $z=0$ stellar and HI mass functions using a particle-swarm optimisation method. The Dark Sage codebase, written in C and Python, is publicly available at https://github.com/arhstevens/DarkSage, Comment: Updates post referee's report. Get in touch for data access. 34 pages before references; 14 figures, 2 tables, 130 equations

Type IIn supernovae (SNe\,IIn) are an uncommon and highly heterogeneous class of SN where the SN ejecta interact with pre-existing circumstellar media (CSM). Previous studies have found a mass ladder in terms of the association of the SN location with H$\alpha$ emission and the progenitor masses of SN classes. In this paper, we present the largest environmental study of SNe\,IIn. We analyse the H$\alpha$ environments of 77 type IIn supernovae using continuum subtracted H$\alpha$ images. We use the pixel statistics technique, normalised cumulative ranking (NCR), to associate SN pixels with H$\alpha$ emission. We find that our 77 SNe\,IIn do not follow the H$\alpha$ emission. This is not consistent with the proposed progenitors of SNe\,IIn, luminous blue variables (LBVs) as LBVs are high mass stars that undergo dramatic episodic mass loss. However, a subset of the NCR values follow the H$\alpha$ emission, suggesting a population of high mass progenitors. This suggests there may be multiple progenitor paths with $\sim$60\% having non-zero NCR values with a distribution consistent with high mass progenitors such as LBVs and $\sim$40\% of these SNe not being associated with H$\alpha$ emission. We discuss the possible progenitor routes of SNe\,IIn, especially for the zero NCR value population. We also investigate the radial distribution of the SNe in their hosts in terms of H$\alpha$ and $r'$-band flux., Comment: 13 pages, 6 figures. Accepted to MNRAS

This work presents measurements of the local HII environment metallicities of core-collapse supernovae (SNe) within a luminosity distance of 30 Mpc. 76 targets were observed at the Isaac Newton Telescope and environment metallicities could be measured for 65 targets using the N2 and O3N2 strong emission line method. The cumulative distribution functions (CDFs) of the environment metallicities of Type Ib and Ic SNe tend to higher metallicity than Type IIP, however Type Ic are also present at lower metallicities whereas Type Ib are not. The Type Ib frequency distribution is narrower (standard deviation $\sim$0.06 dex) than the Ic and IIP distributions ($\sim$0.15 dex) giving some evidence for a significant fraction of single massive progenitor stars; the low metallicity of Type Ic suggests a significant fraction of compact binary progenitors. However, both the Kolmogorov-Smirnov test and the Anderson-Darling test indicate no statistical significance for a difference in the local metallicities of the three SN types. Monte-Carlo simulations reveal a strong sensitivity of these tests to the uncertainties of the derived metallicities. Given the uncertainties of the strong emission methods, the applicability of the tests seems limited. We extended our analysis with the data of the Type Ib/Ic/IIP SN sample from Galbany et al. (2018). The CDFs created with their sample confirm our CDFs very well. The statistical tests, combining our sample and the Galbany et al. (2018) sample, indicate a significant difference between Type Ib and Type IIP with <5% probability that they are drawn from the same parent population., Comment: 19 pages, 10 figures, 10 tables, accepted for publication in MNRAS, minor changes at editor's request

This work presents measurements of the local HII environment metallicities of corecollapse supernovae (SNe) within a luminosity distance of 30 Mpc. 76 targets were observed at the Isaac Newton Telescope and environment metallicities could be measured for 65 targets using the N2 and O3N2 strong emission line method. The cumulative distribution functions (CDFs) of the environment metallicities of Type Ib and Ic SNe tend to higher metallicity than Type IIP, however Type Ic are also present at lower metallicities whereas Type Ib are not. The Type Ib frequency distribution is narrower (standard deviation ∼0.06 dex) than the Ic and IIP distributions (∼0.15 dex) giving some evidence for a significant fraction of single massive progenitor stars; the low metallicity of Type Ic suggests a significant fraction of compact binary progenitors. However, both the Kolmogorov-Smirnov test and the Anderson-Darling test indicate no statistical significance for a difference in the local metallicities of the three SN types. Monte-Carlo simulations reveal a strong sensitivity of these tests to the uncertainties of the derived metallicities. Given the uncertainties of the strong emission methods, the applicability of the tests seems limited. We extended our analysis with the data of the Type Ib/Ic/IIP SN sample from Galbany et al. (2018). The CDFs created with their sample confirm our CDFs very well. The statistical tests, combining our sample and the Galbany et al. (2018) sample, indicate a significant difference between Type Ib and Type IIP with <5% probability that they are drawn from the same parent population.

BACKGROUND: The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis, we found a mouse with an activating mutation in oligoadenylate synthetase 2 (Oas2), a sensor of viral double stranded RNA, that resulted in an interferon response and prevented lactation in otherwise healthy mice. METHODS: To determine if sole activation of Oas2 could alter the course of mammary cancer, we combined the Oas2 mutation with the MMTV-PyMT oncogene model of breast cancer and examined disease progression and the effects of checkpoint immunotherapy using Kaplan-Meier survival analysis with immunohistochemistry and flow cytometry. RESULTS: Oas2 mutation prevented pregnancy from increasing metastases to lung. Checkpoint immunotherapy with antibodies against programmed death-ligand 1 was more effective when the Oas2 mutation was present. CONCLUSIONS: These data establish OAS2 as a therapeutic target for agents designed to reduce metastases and increase the effectiveness of checkpoint immunotherapy.

Anthropogenic landscape modification which leads to the displacement of species, is arguably one of the most profound impacts on animal movement globally. In urban landscapes, animal movement is generally impacted by varying levels of increased urbanization. However, this is species dependent and is mostly guided by the surrounding habitat. Fragmentation and habitat patch isolation must be considered at scales appropriate to the study species. Using telemetry, we test these assumptions investigating movement patterns of flocks of Forest Red-tailed Black Cockatoos (Calyptorhynchus banksii naso; RTBC) between three regions: urban, peri-urban, and forest using GPS and satellite PTT. This species occurs at varying levels of urbanization, however, how this might affect its movements is largely unknown. We did not find evidence that RTBC movement was impaired in the urban region compared with peri-urban or forest regions. It found, however, a significant within-region variation in movement extent among flocks and across regions depending on foraging resource availability and location. Differences in daily movement distance (Av. 4.96 - 16.41 km) and home range size (6.02 - 52.57 km2) between urban flocks appeared to be associated with the proximity of green spaces as roosts and foraging sites, with roadside vegetation providing important foraging resources and movement corridors. Key urban habitats were predominantly located in public nature reserves and private properties, with roadside vegetation connecting these sites for RTBC. The findings of this study highlight that conservation management for this and many other threatened species should regard the urban landscape as a critical habitat for urban adapted species. This would include management of its green spaces with connectivity and offsets from roads in mind. Furthermore, future research should focus on identifying additional key habitat sites (resource selection) and species distribution modeling, which will facil

Fast radio bursts (FRBs) are millisecond-duration pulses of radio emission originating from extragalactic distances. Radio dispersion on each burst is imparted by intervening plasma mostly located in the intergalactic medium. We observe a burst, FRB 20220610A, in a morphologically complex host galaxy system at redshift $z=1.016 \pm 0.002$. The burst redshift and dispersion are consistent with passage through a substantial column of material from the intergalactic medium. The burst shows evidence for passage through additional turbulent magnetized plasma, potentially associated with the host galaxy. We use the burst energy of $2 \times 10^{42}$ erg, to revise the maximum energy of an FRB., Comment: 52 pages

Fast cosmological transients such as fast radio bursts (FRBs) and gamma-ray bursts (GRBs) represent a class of sources more compact than any other cosmological object. As such they are sensitive to significant magnification via gravitational lensing from a class of lenses which are not well-constrained by observations today. Low-mass primordial black holes are one such candidate which may constitute a significant fraction of the Universe's dark matter. Current observations only constrain their density in the nearby Universe, giving fast transients from cosmological distances the potential to form complementary constraints. Motivated by this, we calculate the effect that gravitational lensing from a cosmological distribution of compact objects would have on the observed rates of FRBs and GRBs. For static lensing geometries, we rule out the prospect that all FRBs are gravitationally lensed for a range of lens masses and show that lens masses greater than $10^{-5}M_\odot$ can be constrained with 8000 un-localised high fluence FRBs at 1.4GHz, as might be detected by the next generation of FRB-finding telescopes., Comment: 10 pages (+7 Supplementary). Accepted to MNRAS

Type IIn supernovae (SNe\,IIn) are an uncommon and highly heterogeneous class of SN where the SN ejecta interact with pre-existing circumstellar media (CSM). Previous studies have found a mass ladder in terms of the association of the SN location with H$\alpha$ emission and the progenitor masses of SN classes. In this paper, we present the largest environmental study of SNe\,IIn. We analyse the H$\alpha$ environments of 77 type IIn supernovae using continuum subtracted H$\alpha$ images. We use the pixel statistics technique, normalised cumulative ranking (NCR), to associate SN pixels with H$\alpha$ emission. We find that our 77 SNe\,IIn do not follow the H$\alpha$ emission. This is not consistent with the proposed progenitors of SNe\,IIn, luminous blue variables (LBVs) as LBVs are high mass stars that undergo dramatic episodic mass loss. However, a subset of the NCR values follow the H$\alpha$ emission, suggesting a population of high mass progenitors. This suggests there may be multiple progenitor paths with $\sim$60\% having non-zero NCR values with a distribution consistent with high mass progenitors such as LBVs and $\sim$40\% of these SNe not being associated with H$\alpha$ emission. We discuss the possible progenitor routes of SNe\,IIn, especially for the zero NCR value population. We also investigate the radial distribution of the SNe in their hosts in terms of H$\alpha$ and $r'$-band flux., Comment: 13 pages, 6 figures. Accepted to MNRAS

Background & Aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and replication stress in PC. Methods: We interrogated the transcriptome, genome, proteome, and functional characteristics of 61 novel PC patient–derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient-derived xenografts and human PC organoids. Results: Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors, including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, cosegregates with response to platinum (P <.001) and PARP inhibitor therapy (P <.001) in vitro and in vivo. We generated a novel signature of replication stress that predicts response to ATR (P <.018) and WEE1 inhibitor (P <.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P <.001) but was not associated with DDR deficiency. Conclusions: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR-proficient PC and after platinum therapy.

Type IIn supernovae (SNe IIn) are a relatively infrequently observed subclass of SNe whose photometric and spectroscopic properties are varied. A common thread among SNe IIn are the complex multiple-component hydrogen Balmer lines. Owing to the heterogeneity of SNe IIn, online databases contain some outdated, erroneous, or even contradictory classifications. SN IIn classification is further complicated by SN impostors and contamination from underlying HII regions. We have compiled a catalogue of systematically classified nearby (redshift z < 0.02) SNe IIn using the Open Supernova Catalogue (OSC). We present spectral classifications for 115 objects previously classified as SNe IIn. Our classification is based upon results obtained by fitting multiple Gaussians to the H-alpha profiles. We compare classifications reported by the OSC and Transient Name Server (TNS) along with the best matched templates from SNID. We find that 28 objects have been misclassified as SNe IIn. TNS and OSC can be unreliable; they disagree on the classifications of 51 of the objects and contain a number of erroneous classifications. Furthermore, OSC and TNS hold misclassifications for 34 and twelve (respectively) of the transients we classify as SNe IIn. In total, we classify 87 SNe IIn. We highlight the importance of ensuring that online databases remain up to date when new or even contemporaneous data become available. Our work shows the great range of spectral properties and features that SNe IIn exhibit, which may be linked to multiple progenitor channels and environment diversity. We set out a classification sche me for SNe IIn based on the H-alpha profile which is not greatly affected by the inhomogeneity of SNe IIn., Comment: 22 pages, 15 figures, accepted by MNRAS

Captive breeding is an important tool for amphibian conservation despite high economic costs and deleterious genetic effects of sustained captivity and unavoidably small colony sizes. Integration of biobanking and assisted reproductive technologies (ARTs) could provide solutions to these challenges, but is rarely used due to lack of recognition of the potential benefits and clear policy direction. Here we present compelling genetic and economic arguments to integrate biobanking and ARTs into captive breeding programs using modelled captive populations of two Australian threatened frogs, namely the orange-bellied frog Geocrinia vitellina and the white bellied frog Geocrinia alba. Back-crossing with frozen founder spermatozoa using ARTs every generation minimises rates of inbreeding and provides considerable reductions in colony size and program costs compared with conventional captive management. Biobanking could allow captive institutions to meet or exceed longstanding genetic retention targets (90% of source population heterozygosity over 100 years). We provide a broad policy direction that could make biobanking technology a practical reality across Australia’s ex situ management of amphibians in current and future holdings. Incorporating biobanking technology widely across this network could deliver outcomes by maintaining high levels of source population genetic diversity and freeing economic resources to develop ex situ programs for a greater number of threatened amphibian species.

The COVID-19 pandemic has prompted renewed attention among health professionals, Aboriginal community leaders, and social scientists to the need for culturally responsive preventative health measures and strategies. This article, a collaborative effort, involving Yanyuwa families from the remote community of Borroloola and two anthropologists with whom Yanyuwa have long associations, tracks the story of pandemics from the perspective of Aboriginal people in the Gulf region of northern Australia. It specifically orients the discussion of the current predicament of 'viral vulnerability' in the wake of COVID-19, relative to other pandemics, including the Hong Kong flu in 1969 and the Spanish flu decades earlier in 1919. This discussion highlights that culturally nuanced and prescribed responses to illness and threat of illness have a long history for Yanyuwa. Yanyuwa cultural repertoires have assisted in the process of making sense of massive change, in the form of past pandemics and the onset of sickness, the threat of illness with COVID-19 and the attribution of 'viral vulnerability' to this remote Aboriginal community. The aim is to centralise Yanyuwa voices in this story, as an important step in growing understandings of Aboriginal knowledge of pandemics and culturally relevant and controlled health responses and strategies for communal well-being.

Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby stabilizing, and, in some cases, reversing disability in carefully selected MS patients. However, AHSCT is an intensive chemotherapy-based procedure associated with intrinsic risks, including profound cytopenia, infection, and organ toxicity, accompanied by an on-going degree of immuno-compromise and general deconditioning, which can be associated with a transient increase in functional impairment in the early stages after transplantation. Although international guidelines and recommendations have been published for clinical and technical aspects of AHSCT in MS, there has been no detailed appraisal of the rehabilitation needed following treatment nor any specific guidelines as to how this is best delivered by hospital and community-based therapists and wider multidisciplinary teams in order to maximize functional recovery and quality of life. These expert consensus guidelines aim to address this unmet need by summarizing the evidence-base for AHSCT in MS and providing recommendations for current rehabilitation practice along with identifying areas for future research and development.

Context: The Baudin’s cockatoo is one of three black cockatoo species endemic to Western Australia and is listed as Endangered by state and federal governments. Although there is a Recovery Plan in place for this species, conservation efforts are hindered by gaps in knowledge regarding the species movement ecology. Aims: To identify key foraging and roosting habitat for Baudin’s cockatoos and to determine differences in flock movements, including the spatial extent of movement, in Urban, Peri-urban and Forest regions using telemetry data. Methods: Wild Baudin’s cockatoos that had been injured and undergone rehabilitation were equipped with satellite PTT (platform transmitter terminal) and GPS tags and released back into wild flocks. The study birds, and the flocks into which they integrated, were tracked in the field to collect telemetry and observational data. Satellite data were used to define the types of movement behaviour (resident, ranging, migratory), and GPS data were analysed to determine key foraging and roosting habitat, and to calculate home range area estimates. Key results: There was a significant difference in flock movement between the Urban/Peri-urban regions and the Forest region in terms of daily distances moved and distances between roosts, with these parameters being far greater for the Forest region. Additionally, flock sizes were larger in the Forest region compared with the Urban and Peri-urban regions. In Urban and Peri-urban regions, key habitat comprised remnant vegetation in urban green space (nature reserves, parks and private property), and roadside and riparian vegetation, which served as movement corridors in the landscape. Conclusions: The research shows that it is important to maintain vegetation connectivity in the landscape. This enables Baudin’s cockatoos to utilise key patches of remnant vegetation in their non-breeding wintering grounds in Urban and Peri-urban regions of the Perth Peel Coastal Plain. Further research on the mov

Despite existing constraints, it remains possible that up to $35\%$ of all dark matter is comprised of compact objects, such as the black holes in the 10-100\,M$_\odot$ range whose existence has been confirmed by LIGO. The strong gravitational lensing of transients such as FRBs and GRBs has been suggested as a more sensitive probe for compact dark matter than intensity fluctuations observed in microlensing experiments. Recently ASKAP has reported burst substructure down to $15\mu$s timescales in FRBs in the redshift range $0.3-0.5$. We investigate here the implications of this for the detectability of compact dark matter by FRBs. We find that a sample size of $\sim130$ FRBs would be required to constrain compact dark matter to less than the existing 35$\%$ limit with 95$\%$ confidence, if it were distributed along $\gtrsim 1\,$Gpc-long FRB sightlines through the cosmic web. Conversely, existing constraints on the fraction of compact dark matter permit as many as 1 in $\approx 40$ of all $z \lesssim 0.4$ FRBs to exhibit micro-lensed burst structure. Approximately $170$ FRBs intercepting halos within $\sim 50\,$kpc would be required to exclude the fraction of compact dark matter in each intercepted halo to a similar level. Furthermore, we consider the cumulative effects of lensing of the FRB signal by a macroscopic dark matter distribution. We conclude that lensing from a uniform distribution of compact objects is likely not observable, but suggest that FRBs may set meaningful limits on power-law distributions of dark matter., Comment: 3 Figures, 1 table

We have developed a new coherent dedispersion mode to study the emission of Fast Radio Bursts that trigger the voltage capture capability of the Australian SKA Pathfinder (ASKAP) interferometer. In principle the mode can probe emission timescales down to 3 ns with full polarimetric information preserved. Enabled by the new capability, here we present a spectropolarimetric analysis of FRB 181112 detected by ASKAP, localized to a galaxy at redshift 0.47. At microsecond time resolution the burst is resolved into four narrow pulses with a rise time of just $15 \mu$s for the brightest. The pulses have a diversity of morphology, but do not show evidence for temporal broadening by turbulent plasma along the line of sight, nor is there any evidence for periodicity in their arrival times. The pulses are highly polarized (up to 95%), with the polarization position angle varying both between and within pulses. The pulses have apparent rotation measures that vary by $15\pm 2\, {\rm rad \,m^{-2}}$ and apparent dispersion measures that vary by $0.041\pm 0.004\,{\rm pc\,cm^{-3}}$. Conversion between linear and circular polarization is observed across the brightest pulse. We conclude that the FRB 181112 pulses are most consistent with being a direct manifestation of the emission process or the result of propagation through a relativistic plasma close to the source. This demonstrates that our method, which facilitates high-time-resolution polarimetric observations of FRBs, can be used to study not only burst emission processes, but also a diversity of propagation effects present on the gigaparsec paths they traverse., Comment: Accepted to ApJ Letters; 13 pages, 5 figures