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7 results on '"Manuzak, A."'

1. Cannabis Use Is Associated With Decreased Antiretroviral Therapy Adherence Among Older Adults With HIV

Author

Manuzak, Jennifer A, Manuzak, Jennifer A, Granche, Janeway, Tassiopoulos, Katherine, Rower, Joseph E, Knox, Justin R, Williams, Dionna W, Ellis, Ronald J, Goodkin, Karl, Sharma, Anjali, Erlandson, Kristine M, Team, for the AIDS Clinical Trials Group A5322 Study, Manuzak, Jennifer A, Manuzak, Jennifer A, Granche, Janeway, Tassiopoulos, Katherine, Rower, Joseph E, Knox, Justin R, Williams, Dionna W, Ellis, Ronald J, Goodkin, Karl, Sharma, Anjali, Erlandson, Kristine M, and Team, for the AIDS Clinical Trials Group A5322 Study

Abstract

BackgroundConflicting evidence exists on the impact of cannabis use on antiretroviral therapy (ART) adherence among people with human immunodeficiency virus (PWH). We leveraged data collected among older PWH to characterize longitudinal associations between cannabis use and ART adherence.MethodsAIDS Clinical Trials Group (ACTG) A5322 study participants were categorized as <100% (≥1 missed dose in past 7 days) or 100% (no missed doses) ART adherent. Participants self-reported current (past month), intermittent (past year but not past month), and no cannabis (in past year) use at each study visit. Generalized linear models using generalized estimating equations were fit and inverse probability weighting was used to adjust for time-varying confounders and loss to follow-up.ResultsAmong 1011 participants (median age, 51 years), 18% reported current, 6% intermittent, and 76% no cannabis use at baseline; 88% reported 100% ART adherence. Current cannabis users were more likely to be <100% adherent than nonusers (adjusted risk ratio [aRR], 1.53 [95% CI, 1.11-2.10]). There was no association between ART adherence and current versus intermittent (aRR, 1.39 [95% CI, .85-2.28]) or intermittent versus no cannabis use (aRR, 1.04 [95% CI, .62-1.73]).ConclusionsAmong a cohort of older PWH, current cannabis users had a higher risk of <100% ART adherence compared to nonusers. These findings have important clinical implications as suboptimal ART adherence is associated with ART drug resistance, virologic failure, and elevated risk for mortality. Further research is needed to elucidate the mechanisms by which cannabis use decreases ART adherence in older PWH and to advance the development of more efficacious methods to mitigate nonadherence in this vulnerable population.

Published
2023

3. Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy–Treated Human Immunodeficiency Virus–Infected Individuals

Author

Manuzak, Jennifer A, Manuzak, Jennifer A, Gott, Toni M, Kirkwood, Jay S, Coronado, Ernesto, Hensley-McBain, Tiffany, Miller, Charlene, Cheu, Ryan K, Collier, Ann C, Funderburg, Nicholas T, Martin, Jeffery N, Wu, Michael C, Isoherranen, Nina, Hunt, Peter W, Klatt, Nichole R, Manuzak, Jennifer A, Manuzak, Jennifer A, Gott, Toni M, Kirkwood, Jay S, Coronado, Ernesto, Hensley-McBain, Tiffany, Miller, Charlene, Cheu, Ryan K, Collier, Ann C, Funderburg, Nicholas T, Martin, Jeffery N, Wu, Michael C, Isoherranen, Nina, Hunt, Peter W, and Klatt, Nichole R

Published
2018

4. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Author

Hensley-McBain, Tiffany, Hensley-McBain, Tiffany, Wu, Michael C, Manuzak, Jennifer A, Cheu, Ryan K, Gustin, Andrew, Driscoll, Connor B, Zevin, Alexander S, Miller, Charlene J, Coronado, Ernesto, Smith, Elise, Chang, Jean, Gale, Michael, Somsouk, Ma, Burgener, Adam D, Hunt, Peter W, Hope, Thomas J, Collier, Ann C, Klatt, Nichole R, Hensley-McBain, Tiffany, Hensley-McBain, Tiffany, Wu, Michael C, Manuzak, Jennifer A, Cheu, Ryan K, Gustin, Andrew, Driscoll, Connor B, Zevin, Alexander S, Miller, Charlene J, Coronado, Ernesto, Smith, Elise, Chang, Jean, Gale, Michael, Somsouk, Ma, Burgener, Adam D, Hunt, Peter W, Hope, Thomas J, Collier, Ann C, and Klatt, Nichole R

Abstract

Gastrointestinal (GI) mucosal dysfunction predicts and likely contributes to non-infectious comorbidities and mortality in HIV infection and persists despite antiretroviral therapy. However, the mechanisms underlying this dysfunction remain incompletely understood. Neutrophils are important for containment of pathogens but can also contribute to tissue damage due to their release of reactive oxygen species and other potentially harmful effector molecules. Here we used a flow cytometry approach to investigate increased neutrophil lifespan as a mechanism for GI neutrophil accumulation in chronic, treated HIV infection and a potential role for gastrointestinal dysbiosis. We report that increased neutrophil survival contributes to neutrophil accumulation in colorectal biopsy tissue, thus implicating neutrophil lifespan as a new therapeutic target for mucosal inflammation in HIV infection. Additionally, we characterized the intestinal microbiome of colorectal biopsies using 16S rRNA sequencing. We found that a reduced Lactobacillus: Prevotella ratio associated with neutrophil survival, suggesting that intestinal bacteria may contribute to GI neutrophil accumulation in treated HIV infection. Finally, we provide evidence that Lactobacillus species uniquely decrease neutrophil survival and neutrophil frequency in vitro, which could have important therapeutic implications for reducing neutrophil-driven inflammation in HIV and other chronic inflammatory conditions.

Published
2019

5. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Author

Hensley-McBain, Tiffany, Douek, Daniel C1, Hensley-McBain, Tiffany, Wu, Michael C, Manuzak, Jennifer A, Cheu, Ryan K, Gustin, Andrew, Driscoll, Connor B, Zevin, Alexander S, Miller, Charlene J, Coronado, Ernesto, Smith, Elise, Chang, Jean, Gale, Michael, Somsouk, Ma, Burgener, Adam D, Hunt, Peter W, Hope, Thomas J, Collier, Ann C, Klatt, Nichole R, Hensley-McBain, Tiffany, Douek, Daniel C1, Hensley-McBain, Tiffany, Wu, Michael C, Manuzak, Jennifer A, Cheu, Ryan K, Gustin, Andrew, Driscoll, Connor B, Zevin, Alexander S, Miller, Charlene J, Coronado, Ernesto, Smith, Elise, Chang, Jean, Gale, Michael, Somsouk, Ma, Burgener, Adam D, Hunt, Peter W, Hope, Thomas J, Collier, Ann C, and Klatt, Nichole R

Abstract

Gastrointestinal (GI) mucosal dysfunction predicts and likely contributes to non-infectious comorbidities and mortality in HIV infection and persists despite antiretroviral therapy. However, the mechanisms underlying this dysfunction remain incompletely understood. Neutrophils are important for containment of pathogens but can also contribute to tissue damage due to their release of reactive oxygen species and other potentially harmful effector molecules. Here we used a flow cytometry approach to investigate increased neutrophil lifespan as a mechanism for GI neutrophil accumulation in chronic, treated HIV infection and a potential role for gastrointestinal dysbiosis. We report that increased neutrophil survival contributes to neutrophil accumulation in colorectal biopsy tissue, thus implicating neutrophil lifespan as a new therapeutic target for mucosal inflammation in HIV infection. Additionally, we characterized the intestinal microbiome of colorectal biopsies using 16S rRNA sequencing. We found that a reduced Lactobacillus: Prevotella ratio associated with neutrophil survival, suggesting that intestinal bacteria may contribute to GI neutrophil accumulation in treated HIV infection. Finally, we provide evidence that Lactobacillus species uniquely decrease neutrophil survival and neutrophil frequency in vitro, which could have important therapeutic implications for reducing neutrophil-driven inflammation in HIV and other chronic inflammatory conditions.

Published
2019

6. Oral abstracts of the 21st International AIDS Conference 18-22 July 2016, Durban, South Africa.

Author

Ericsen, A, Ericsen, A, Lauck, M, Mohns, M, Dinapoli, S, Mutschler, J, Greene, J, Weinfurter, J, Lehrer-Brey, G, Crosno, K, Peterson, E, Reynolds, M, Wiseman, R, Burwitz, B, Sacha, J, Friedrich, T, Brenchley, J, O'Connor, D, Xu, C, He, T, Haret-Richter, G, Franck, D, Policicchio, B, Brocca-Cofano, E, Ma, D, Stock, J, Tracy, R, Landay, A, Wilson, C, Apetrei, C, Pandrea, I, Wong, EB, Xulu, B, Prakadan, S, Shalek, AK, Lalloo, U, Baijnath, P, Suleman, M, Moodley, V, Mitha, M, Maharaj, P, Costiniuk, C, Nielsen, M, Mhlane, Z, Karim, F, Lewinsohn, D, Ndung'u, T, Pasternak, A, Prins, J, Berkhout, B, Leon-Fuentes, L, Viveros-Rogel, M, Vergara-Mendoza, M, Rodriguez-Castañón, M, Cardenas-Ochoa, A, Tello-Mercado, A, Vega, C, Sierra-Madero, J, Soto-Ramirez, L, Perez-Patrigeon, S, Hensley-Mcbain, T, Cheu, R, Manuzak, J, Zevin, A, Miller, C, Lee, E, Burgener, A, Klatt, N, Mellins, CA, Abrams, EJ, Dolezal, C, Warne, P, Elkington, K, Bucek, A, Leu, CS, Maskew, M, Bor, J, MacLeod, W, Carmona, S, Sherman, G, Fox, MP, Judd, A, Chappell, E, Doerholt, K, Galli, L, Giaquinto, C, Gibb, D, Goetghebuer, T, Le Coeur, S, Julian, A Noguera, Turkova, A, Goodall, R, Davies, M-A, Sawry, S, Phiri, S, Rabie, H, Eley, B, Fatti, G, Technau, K-G, Tanser, F, Ericsen, A, Ericsen, A, Lauck, M, Mohns, M, Dinapoli, S, Mutschler, J, Greene, J, Weinfurter, J, Lehrer-Brey, G, Crosno, K, Peterson, E, Reynolds, M, Wiseman, R, Burwitz, B, Sacha, J, Friedrich, T, Brenchley, J, O'Connor, D, Xu, C, He, T, Haret-Richter, G, Franck, D, Policicchio, B, Brocca-Cofano, E, Ma, D, Stock, J, Tracy, R, Landay, A, Wilson, C, Apetrei, C, Pandrea, I, Wong, EB, Xulu, B, Prakadan, S, Shalek, AK, Lalloo, U, Baijnath, P, Suleman, M, Moodley, V, Mitha, M, Maharaj, P, Costiniuk, C, Nielsen, M, Mhlane, Z, Karim, F, Lewinsohn, D, Ndung'u, T, Pasternak, A, Prins, J, Berkhout, B, Leon-Fuentes, L, Viveros-Rogel, M, Vergara-Mendoza, M, Rodriguez-Castañón, M, Cardenas-Ochoa, A, Tello-Mercado, A, Vega, C, Sierra-Madero, J, Soto-Ramirez, L, Perez-Patrigeon, S, Hensley-Mcbain, T, Cheu, R, Manuzak, J, Zevin, A, Miller, C, Lee, E, Burgener, A, Klatt, N, Mellins, CA, Abrams, EJ, Dolezal, C, Warne, P, Elkington, K, Bucek, A, Leu, CS, Maskew, M, Bor, J, MacLeod, W, Carmona, S, Sherman, G, Fox, MP, Judd, A, Chappell, E, Doerholt, K, Galli, L, Giaquinto, C, Gibb, D, Goetghebuer, T, Le Coeur, S, Julian, A Noguera, Turkova, A, Goodall, R, Davies, M-A, Sawry, S, Phiri, S, Rabie, H, Eley, B, Fatti, G, Technau, K-G, and Tanser, F

Published
2016

7. Oral abstracts of the 21st International AIDS Conference 18-22 July 2016, Durban, South Africa.

Author

Ericsen, A, Ericsen, A, Lauck, M, Mohns, M, Dinapoli, S, Mutschler, J, Greene, J, Weinfurter, J, Lehrer‐Brey, G, Crosno, K, Peterson, E, Reynolds, M, Wiseman, R, Burwitz, B, Sacha, J, Friedrich, T, Brenchley, J, O'Connor, D, Xu, C, He, T, Haret‐Richter, G, Franck, D, Policicchio, B, Brocca‐Cofano, E, Ma, D, Stock, J, Tracy, R, Landay, A, Wilson, C, Apetrei, C, Pandrea, I, Wong, EB, Xulu, B, Prakadan, S, Shalek, AK, Lalloo, U, Baijnath, P, Suleman, M, Moodley, V, Mitha, M, Maharaj, P, Costiniuk, C, Nielsen, M, Mhlane, Z, Karim, F, Lewinsohn, D, Ndung'u, T, Pasternak, A, Prins, J, Berkhout, B, Leon‐Fuentes, L, Viveros‐Rogel, M, Vergara‐Mendoza, M, Rodriguez‐Castañón, M, Cardenas‐Ochoa, A, Tello‐Mercado, A, Vega, C, Sierra‐Madero, J, Soto‐Ramirez, L, Perez‐Patrigeon, S, Hensley‐Mcbain, T, Cheu, R, Manuzak, J, Zevin, A, Miller, C, Lee, E, Burgener, A, Klatt, N, Mellins, CA, Abrams, EJ, Dolezal, C, Warne, P, Elkington, K, Bucek, A, Leu, CS, Maskew, M, Bor, J, MacLeod, W, Carmona, S, Sherman, G, Fox, MP, Judd, A, Chappell, E, Doerholt, K, Galli, L, Giaquinto, C, Gibb, D, Goetghebuer, T, Le Coeur, S, Julian, A Noguera, Turkova, A, Goodall, R, Collaboration, European Pregnancy and Paediatric Hiv Cohort, Davies, M‐A, Sawry, S, Phiri, S, Rabie, H, Eley, B, Fatti, G, Technau, K‐G, Ericsen, A, Ericsen, A, Lauck, M, Mohns, M, Dinapoli, S, Mutschler, J, Greene, J, Weinfurter, J, Lehrer‐Brey, G, Crosno, K, Peterson, E, Reynolds, M, Wiseman, R, Burwitz, B, Sacha, J, Friedrich, T, Brenchley, J, O'Connor, D, Xu, C, He, T, Haret‐Richter, G, Franck, D, Policicchio, B, Brocca‐Cofano, E, Ma, D, Stock, J, Tracy, R, Landay, A, Wilson, C, Apetrei, C, Pandrea, I, Wong, EB, Xulu, B, Prakadan, S, Shalek, AK, Lalloo, U, Baijnath, P, Suleman, M, Moodley, V, Mitha, M, Maharaj, P, Costiniuk, C, Nielsen, M, Mhlane, Z, Karim, F, Lewinsohn, D, Ndung'u, T, Pasternak, A, Prins, J, Berkhout, B, Leon‐Fuentes, L, Viveros‐Rogel, M, Vergara‐Mendoza, M, Rodriguez‐Castañón, M, Cardenas‐Ochoa, A, Tello‐Mercado, A, Vega, C, Sierra‐Madero, J, Soto‐Ramirez, L, Perez‐Patrigeon, S, Hensley‐Mcbain, T, Cheu, R, Manuzak, J, Zevin, A, Miller, C, Lee, E, Burgener, A, Klatt, N, Mellins, CA, Abrams, EJ, Dolezal, C, Warne, P, Elkington, K, Bucek, A, Leu, CS, Maskew, M, Bor, J, MacLeod, W, Carmona, S, Sherman, G, Fox, MP, Judd, A, Chappell, E, Doerholt, K, Galli, L, Giaquinto, C, Gibb, D, Goetghebuer, T, Le Coeur, S, Julian, A Noguera, Turkova, A, Goodall, R, Collaboration, European Pregnancy and Paediatric Hiv Cohort, Davies, M‐A, Sawry, S, Phiri, S, Rabie, H, Eley, B, Fatti, G, and Technau, K‐G

Published
2016

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