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The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

In Non-Local Means (NLM), each pixel is denoised by performing a weighted averaging of its neighboring pixels, where the weights are computed using image patches. We demonstrate that the denoising performance of NLM can be improved by pruning the neighboring pixels, namely, by rejecting neighboring pixels whose weights are below a certain threshold $\lambda$. While pruning can potentially reduce pixel averaging in uniform-intensity regions, we demonstrate that there is generally an overall improvement in the denoising performance. In particular, the improvement comes from pixels situated close to edges and corners. The success of the proposed method strongly depends on the choice of the global threshold $\lambda$, which in turn depends on the noise level and the image characteristics. We show how Stein's unbiased estimator of the mean-squared error can be used to optimally tune $\lambda$, at a marginal computational overhead. We present some representative denoising results to demonstrate the superior performance of the proposed method over NLM and its variants., Comment: Published in IET Image Processing