17 results on '"MacGregor G."'
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2. P1691Impact of dose and duration of dietary salt reduction on blood pressure levels: systematic review and meta-analysis of randomised trials
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Huang, L, Trieu, K ; https://orcid.org/0000-0003-1848-2741, Yoshimura, S, Woodward, M ; https://orcid.org/0000-0001-9800-5296, Campbell, N, Lackland, D, Leung, A, Anderson, CAM, MacGregor, G, Neal, B, He, F, Huang, L, Trieu, K ; https://orcid.org/0000-0003-1848-2741, Yoshimura, S, Woodward, M ; https://orcid.org/0000-0001-9800-5296, Campbell, N, Lackland, D, Leung, A, Anderson, CAM, MacGregor, G, Neal, B, and He, F
- Abstract
Background Authoritative medical and public health agencies in most countries advise to reduce population dietary salt intake to under 5–6 g/day as a strategy for preventing high blood pressure and cardiovascular disease. However, there is still dispute about whether salt reduction should be adopted by all populations. In addition, the effect of duration of dietary salt reduction has not been sufficiently investigated. Purpose To understand the effect of dietary salt reduction on blood pressure and the impact of intervention duration. Methods A systematic review and meta-analysis was conducted. Randomized controlled trials that allocated participants to low and high salt intake, without confounding from unequal concomitant interventions, were included. We excluded studies done in individuals younger than 18 years, pregnant women, individuals with renal disease or heart failure, and studies with sodium excretion estimated from spot urine. Random effect meta-analysis was used to generate pooled estimates of the effect on 24-hour urinary sodium excretion, systolic and diastolic blood pressure. Multivariate meta-regression was used to quantify the dose response effect of dietary salt on blood pressure change and to understand the impact of the intervention duration. Results 125 studies were included with 162 data points extracted. Ninety-nine data points (61%) had interventions under 4 weeks. Overall, 24-hour urinary sodium excretion changed by −141 mmol (95% CI: −156; −126), systolic blood pressure changed by −4.4 mm Hg (95% CI: −5.2; −3.7) and diastolic blood pressure changed by −2.4 mm Hg (95% CI: −2.9; −1.9). Sodium reduction resulted in a significant decrease of systolic blood pressure in all subgroups except in participants with low baseline sodium intake (<109 mmol) (Figure 1). Each 100 mmol reduction of sodium was associated with 2.7 mm Hg (95% CI: 1.0; 4.4; p=0.002) reduction of systolic blood pressure and 1.2 mm Hg (95% CI: 0.0; 2.4; p=0.046) reduction of d
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- 2019
3. The International Consortium for Quality Research on Dietary Sodium/Salt (TRUE) position statement on the use of 24-hour, spot, and short duration (<24 hours) timed urine collections to assess dietary sodium intake
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Campbell, NRC, He, FJ, Tan, M, Cappuccio, FP, Neal, B ; https://orcid.org/0000-0002-0490-7465, Woodward, M ; https://orcid.org/0000-0001-9800-5296, Cogswell, ME, McLean, R, Arcand, J, MacGregor, G, Whelton, P, Jula, A, L'Abbe, MR, Cobb, LK, Lackland, DT, Campbell, NRC, He, FJ, Tan, M, Cappuccio, FP, Neal, B ; https://orcid.org/0000-0002-0490-7465, Woodward, M ; https://orcid.org/0000-0001-9800-5296, Cogswell, ME, McLean, R, Arcand, J, MacGregor, G, Whelton, P, Jula, A, L'Abbe, MR, Cobb, LK, and Lackland, DT
- Abstract
The International Consortium for Quality Research on Dietary Sodium/Salt (TRUE) is a coalition of intentional and national health and scientific organizations formed because of concerns low-quality research methods were creating controversy regarding dietary salt reduction. One of the main sources of controversy is believed related to errors in estimating sodium intake with urine studies. The recommendations and positions in this manuscript were generated following a series of systematic reviews and analyses by experts in hypertension, nutrition, statistics, and dietary sodium. To assess the population's current 24-hour dietary sodium ingestion, single complete 24-hour urine samples, collected over a series of days from a representative population sample, were recommended. To accurately estimate usual dietary sodium at the individual level, at least 3 non-consecutive complete 24-hour urine collections obtained over a series of days that reflect the usual short-term variations in dietary pattern were recommended. Multiple 24-hour urine collections over several years were recommended to estimate an individual's usual long-term sodium intake. The role of single spot or short duration timed urine collections in assessing population average sodium intake requires more research. Single or multiple spot or short duration timed urine collections are not recommended for assessing an individual's sodium intake especially in relationship to health outcomes. The recommendations should be applied by scientific review committees, granting agencies, editors and journal reviewers, investigators, policymakers, and those developing and creating dietary sodium recommendations. Low-quality research on dietary sodium/salt should not be funded, conducted, or published.
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- 2019
4. Recommended standards for assessing blood pressure in human research where blood pressure or hypertension is a major focus
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Daniels, S. Cappuccio, F.P. Lisheng, L. Kaczorowski, J. Jula, A. Atrey, A. Touyz, R. Ramirez, A. Correa-Rotter, R. Weber, M. Webster, J. Legetic, B. Campbell, N. Hankey, G. Waqanivalu, T. Anderson, C. Appel, L. Cogswell, M. Loustalot, F. Cook, N. L'Abbe, M. MacGregor, G. McLean, R. Rabi, D. Khalsa, T. Leung, A. Woodward, M. Arcand, J. Johnson, C. Niebylski, M. Gelfer, M. Ordunez, P. Alpert, B. Padwal, R. Cloutier, L. Stergiou, G. O'Brien, E. MacKay, D. Myers, M. Flynn, J. Feber, J. Rakotz, M. Dionne, J. Mangat, B. True Consortium and Daniels, S. Cappuccio, F.P. Lisheng, L. Kaczorowski, J. Jula, A. Atrey, A. Touyz, R. Ramirez, A. Correa-Rotter, R. Weber, M. Webster, J. Legetic, B. Campbell, N. Hankey, G. Waqanivalu, T. Anderson, C. Appel, L. Cogswell, M. Loustalot, F. Cook, N. L'Abbe, M. MacGregor, G. McLean, R. Rabi, D. Khalsa, T. Leung, A. Woodward, M. Arcand, J. Johnson, C. Niebylski, M. Gelfer, M. Ordunez, P. Alpert, B. Padwal, R. Cloutier, L. Stergiou, G. O'Brien, E. MacKay, D. Myers, M. Flynn, J. Feber, J. Rakotz, M. Dionne, J. Mangat, B. True Consortium
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- 2017
5. Developing consensus measures for global programs: Lessons from the Global Alliance for Chronic Diseases Hypertension research program.
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Li X., Oldenburg B., Riddell M., Srikanth V., Heritier S., Kalyanram K., Kartik K., Suresh O., Maulik P., Salam A., Sudhir T., Thankappan K., Thirunavukkarasu S., Varma R., Thomas N., Clifford G., Prabhakaran D., Thom S., Shivashankar R., Mohan S., Reddy K.S., Krishnan A., Faletoese S., Ieremia M., Ulberg C., Viali S., Pillay A., Sukhu A., Schultz J., Siitia J., Snowdon W., Antonio Bernabe-Ortiz, Cardenas M.K., Gilman R.H., Miranda J.J., Diez-Canseco F., Ponce-Lucero V., Sacksteder K., Gyamfi J., Ogedegbe O., Apusiga K., Cooper R., Ntim M., Plange-Rhule J., Rotich J., Binanay C., Finkelstein E., Bloomfield G., DeLong A., Hogan J., Inui T., Naanyu V., Fuster V., Horowitz C., Kimaiyo S., Kofler C., Menya D., Kamano J.H., Vedanthan R., Velazquez E., Were M., Dolan J., Irazola V., Krousel-Wood M., Augustovski F., Beratarrechea A., Chen J., He J., Mills K., Poggio R., Rubinstein A., Shi L., Webber L., Akinyemi R., Arulogun O., Hurst S., Waddy S., Warth S., Gebregziabher M., Uvere E., Riddell M.A., Edwards N., Thompson S.R., Bernabe-Ortiz A., Praveen D., Johnson C., Kengne A.P., Liu P., McCready T., Ng E., Nieuwlaat R., Ovbiagele B., Owolabi M., Peiris D., Thrift A.G., Tobe S., Yusoff K., de Villiers A., He F., MacGregor G., Jan S., Neal B., Chow C., Joshi R., MacMahon S., Patel A., Rodgers A., Webster R., Keat N.K., Attaran A., Mills E., Muldoon K., Yaya S., Featherstone A., Mukasa B., Forrest J., Kalyesubula R., Kamwesiga J., Lopez P.C., Tayari J.-C., Lopez P., Casas J.L., McKee M., Zainal A.O., Yusuf S., Campbell N., Kilonzo K., Marr M., Yeates K., Feng X., Yuan J., Lin C.-P., Yan L., Zhang J., Wu Y., Ma J., Wang H., Ma Y., Nowson C., Moodie M., Goudge J., Kabudula C., Limbani F., Masilela N., Myakayaka N., Gomez-Olive F.X., Thorogood M., Arabshahi S., Evans R., Mahal A., Li X., Oldenburg B., Riddell M., Srikanth V., Heritier S., Kalyanram K., Kartik K., Suresh O., Maulik P., Salam A., Sudhir T., Thankappan K., Thirunavukkarasu S., Varma R., Thomas N., Clifford G., Prabhakaran D., Thom S., Shivashankar R., Mohan S., Reddy K.S., Krishnan A., Faletoese S., Ieremia M., Ulberg C., Viali S., Pillay A., Sukhu A., Schultz J., Siitia J., Snowdon W., Antonio Bernabe-Ortiz, Cardenas M.K., Gilman R.H., Miranda J.J., Diez-Canseco F., Ponce-Lucero V., Sacksteder K., Gyamfi J., Ogedegbe O., Apusiga K., Cooper R., Ntim M., Plange-Rhule J., Rotich J., Binanay C., Finkelstein E., Bloomfield G., DeLong A., Hogan J., Inui T., Naanyu V., Fuster V., Horowitz C., Kimaiyo S., Kofler C., Menya D., Kamano J.H., Vedanthan R., Velazquez E., Were M., Dolan J., Irazola V., Krousel-Wood M., Augustovski F., Beratarrechea A., Chen J., He J., Mills K., Poggio R., Rubinstein A., Shi L., Webber L., Akinyemi R., Arulogun O., Hurst S., Waddy S., Warth S., Gebregziabher M., Uvere E., Riddell M.A., Edwards N., Thompson S.R., Bernabe-Ortiz A., Praveen D., Johnson C., Kengne A.P., Liu P., McCready T., Ng E., Nieuwlaat R., Ovbiagele B., Owolabi M., Peiris D., Thrift A.G., Tobe S., Yusoff K., de Villiers A., He F., MacGregor G., Jan S., Neal B., Chow C., Joshi R., MacMahon S., Patel A., Rodgers A., Webster R., Keat N.K., Attaran A., Mills E., Muldoon K., Yaya S., Featherstone A., Mukasa B., Forrest J., Kalyesubula R., Kamwesiga J., Lopez P.C., Tayari J.-C., Lopez P., Casas J.L., McKee M., Zainal A.O., Yusuf S., Campbell N., Kilonzo K., Marr M., Yeates K., Feng X., Yuan J., Lin C.-P., Yan L., Zhang J., Wu Y., Ma J., Wang H., Ma Y., Nowson C., Moodie M., Goudge J., Kabudula C., Limbani F., Masilela N., Myakayaka N., Gomez-Olive F.X., Thorogood M., Arabshahi S., Evans R., and Mahal A.
- Abstract
Background: The imperative to improve global health has prompted transnational research partnerships to investigate common health issues on a larger scale. The Global Alliance for Chronic Diseases (GACD) is an alliance of national research funding agencies. To enhance research funded by GACD members, this study aimed to standardise data collection methods across the 15 GACD hypertension research teams and evaluate the uptake of these standardised measurements. Furthermore we describe concerns and difficulties associated with the data harmonisation process highlighted and debated during annual meetings of the GACD funded investigators. With these concerns and issues in mind, a working group comprising representatives from the 15 studies iteratively identified and proposed a set of common measures for inclusion in each of the teams' data collection plans. One year later all teams were asked which consensus measures had been implemented. Result(s): Important issues were identified during the data harmonisation process relating to data ownership, sharing methodologies and ethical concerns. Measures were assessed across eight domains; demographic; dietary; clinical and anthropometric; medical history; hypertension knowledge; physical activity; behavioural (smoking and alcohol); and biochemical domains. Identifying validated measures relevant across a variety of settings presented some difficulties. The resulting GACD hypertension data dictionary comprises 67 consensus measures. Of the 14 responding teams, only two teams were including more than 50 consensus variables, five teams were including between 25 and 50 consensus variables and four teams were including between 6 and 24 consensus variables, one team did not provide details of the variables collected and two teams did not include any of the consensus variables as the project had already commenced or the measures were not relevant to their study. Conclusion(s): Deriving consensus measures across diverse research pro
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- 2017
6. Developing consensus measures for global programs: Lessons from the Global Alliance for Chronic Diseases Hypertension research program.
- Author
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Li X., Oldenburg B., Riddell M., Srikanth V., Heritier S., Kalyanram K., Kartik K., Suresh O., Maulik P., Salam A., Sudhir T., Thankappan K., Thirunavukkarasu S., Varma R., Thomas N., Clifford G., Prabhakaran D., Thom S., Shivashankar R., Mohan S., Reddy K.S., Krishnan A., Faletoese S., Ieremia M., Ulberg C., Viali S., Pillay A., Sukhu A., Schultz J., Siitia J., Snowdon W., Antonio Bernabe-Ortiz, Cardenas M.K., Gilman R.H., Miranda J.J., Diez-Canseco F., Ponce-Lucero V., Sacksteder K., Gyamfi J., Ogedegbe O., Apusiga K., Cooper R., Ntim M., Plange-Rhule J., Rotich J., Binanay C., Finkelstein E., Bloomfield G., DeLong A., Hogan J., Inui T., Naanyu V., Fuster V., Horowitz C., Kimaiyo S., Kofler C., Menya D., Kamano J.H., Vedanthan R., Velazquez E., Were M., Dolan J., Irazola V., Krousel-Wood M., Augustovski F., Beratarrechea A., Chen J., He J., Mills K., Poggio R., Rubinstein A., Shi L., Webber L., Akinyemi R., Arulogun O., Hurst S., Waddy S., Warth S., Gebregziabher M., Uvere E., Riddell M.A., Edwards N., Thompson S.R., Bernabe-Ortiz A., Praveen D., Johnson C., Kengne A.P., Liu P., McCready T., Ng E., Nieuwlaat R., Ovbiagele B., Owolabi M., Peiris D., Thrift A.G., Tobe S., Yusoff K., de Villiers A., He F., MacGregor G., Jan S., Neal B., Chow C., Joshi R., MacMahon S., Patel A., Rodgers A., Webster R., Keat N.K., Attaran A., Mills E., Muldoon K., Yaya S., Featherstone A., Mukasa B., Forrest J., Kalyesubula R., Kamwesiga J., Lopez P.C., Tayari J.-C., Lopez P., Casas J.L., McKee M., Zainal A.O., Yusuf S., Campbell N., Kilonzo K., Marr M., Yeates K., Feng X., Yuan J., Lin C.-P., Yan L., Zhang J., Wu Y., Ma J., Wang H., Ma Y., Nowson C., Moodie M., Goudge J., Kabudula C., Limbani F., Masilela N., Myakayaka N., Gomez-Olive F.X., Thorogood M., Arabshahi S., Evans R., Mahal A., Li X., Oldenburg B., Riddell M., Srikanth V., Heritier S., Kalyanram K., Kartik K., Suresh O., Maulik P., Salam A., Sudhir T., Thankappan K., Thirunavukkarasu S., Varma R., Thomas N., Clifford G., Prabhakaran D., Thom S., Shivashankar R., Mohan S., Reddy K.S., Krishnan A., Faletoese S., Ieremia M., Ulberg C., Viali S., Pillay A., Sukhu A., Schultz J., Siitia J., Snowdon W., Antonio Bernabe-Ortiz, Cardenas M.K., Gilman R.H., Miranda J.J., Diez-Canseco F., Ponce-Lucero V., Sacksteder K., Gyamfi J., Ogedegbe O., Apusiga K., Cooper R., Ntim M., Plange-Rhule J., Rotich J., Binanay C., Finkelstein E., Bloomfield G., DeLong A., Hogan J., Inui T., Naanyu V., Fuster V., Horowitz C., Kimaiyo S., Kofler C., Menya D., Kamano J.H., Vedanthan R., Velazquez E., Were M., Dolan J., Irazola V., Krousel-Wood M., Augustovski F., Beratarrechea A., Chen J., He J., Mills K., Poggio R., Rubinstein A., Shi L., Webber L., Akinyemi R., Arulogun O., Hurst S., Waddy S., Warth S., Gebregziabher M., Uvere E., Riddell M.A., Edwards N., Thompson S.R., Bernabe-Ortiz A., Praveen D., Johnson C., Kengne A.P., Liu P., McCready T., Ng E., Nieuwlaat R., Ovbiagele B., Owolabi M., Peiris D., Thrift A.G., Tobe S., Yusoff K., de Villiers A., He F., MacGregor G., Jan S., Neal B., Chow C., Joshi R., MacMahon S., Patel A., Rodgers A., Webster R., Keat N.K., Attaran A., Mills E., Muldoon K., Yaya S., Featherstone A., Mukasa B., Forrest J., Kalyesubula R., Kamwesiga J., Lopez P.C., Tayari J.-C., Lopez P., Casas J.L., McKee M., Zainal A.O., Yusuf S., Campbell N., Kilonzo K., Marr M., Yeates K., Feng X., Yuan J., Lin C.-P., Yan L., Zhang J., Wu Y., Ma J., Wang H., Ma Y., Nowson C., Moodie M., Goudge J., Kabudula C., Limbani F., Masilela N., Myakayaka N., Gomez-Olive F.X., Thorogood M., Arabshahi S., Evans R., and Mahal A.
- Abstract
Background: The imperative to improve global health has prompted transnational research partnerships to investigate common health issues on a larger scale. The Global Alliance for Chronic Diseases (GACD) is an alliance of national research funding agencies. To enhance research funded by GACD members, this study aimed to standardise data collection methods across the 15 GACD hypertension research teams and evaluate the uptake of these standardised measurements. Furthermore we describe concerns and difficulties associated with the data harmonisation process highlighted and debated during annual meetings of the GACD funded investigators. With these concerns and issues in mind, a working group comprising representatives from the 15 studies iteratively identified and proposed a set of common measures for inclusion in each of the teams' data collection plans. One year later all teams were asked which consensus measures had been implemented. Result(s): Important issues were identified during the data harmonisation process relating to data ownership, sharing methodologies and ethical concerns. Measures were assessed across eight domains; demographic; dietary; clinical and anthropometric; medical history; hypertension knowledge; physical activity; behavioural (smoking and alcohol); and biochemical domains. Identifying validated measures relevant across a variety of settings presented some difficulties. The resulting GACD hypertension data dictionary comprises 67 consensus measures. Of the 14 responding teams, only two teams were including more than 50 consensus variables, five teams were including between 25 and 50 consensus variables and four teams were including between 6 and 24 consensus variables, one team did not provide details of the variables collected and two teams did not include any of the consensus variables as the project had already commenced or the measures were not relevant to their study. Conclusion(s): Deriving consensus measures across diverse research pro
- Published
- 2017
7. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
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Bryant, J.M., Grogono, D.M., Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jönsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., Ingen, J. van, Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., Floto, R.A., Bryant, J.M., Grogono, D.M., Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jönsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., Ingen, J. van, Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., and Floto, R.A.
- Abstract
Item does not contain fulltext
- Published
- 2016
8. The Global Alliance for Chronic Diseases Supports 15 Major Studies in Hypertension Prevention and Control in Low- and Middle-Income Countries
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W.Tobe, S, Attaran, A, de Villiers, A, Featherstone, A, Forrest, J, Kalyesubula, R, Kamwesiga, J, Kengne, AP, Lopez, PC, Mills, E, Mukasa, B, Muldoon, K, Tayari, JC, Yaya, S, Kien Keat, N, Casas, JL, McCready, T, McKee, M, Ng, E, Nieuwlaat, R, Zainal, AO, Yusoff, K, Yusuf, S, Campbell, N, Kilonzo, K, Liu, P, Marr, M, Yeates, K, Feng, X, He, F, Jan, S ; https://orcid.org/0000-0003-2839-1405, Li, X ; https://orcid.org/0000-0001-5445-4022, Lin, CP, Ma, J, Ma, Y, MacGregor, G, Nowson, C, Wang, H, Wu, Y, Yan, L, Yuan, J, Zhang, J, Goudge, J, Kabudula, C, Limbani, F, Masilela, N, Myakayaka, N, Thorogood, M, Gómez-Olivé, FX, Arabshahi, S, Chow, C, Evans, R, Joshi, R ; https://orcid.org/0000-0002-3374-401X, Kalyanram, K, Kartik, K, Mahal, A, Maulik, P ; https://orcid.org/0000-0001-6835-6175, Oldenburg, B, Riddell, M ; https://orcid.org/0000-0001-8852-0569, Srikanth, V, Suresh, O, Thankappan, K, Thirunavukkarasu, S, Thomas, N, Thrift, AG, Varma, R, Clifford, G, Heritier, S, MacMahon, S ; https://orcid.org/0000-0003-2064-7699, Patel, A ; https://orcid.org/0000-0003-3825-4092, Peiris, D ; https://orcid.org/0000-0002-6898-3870, Prabhakaran, D, Praveen, D ; https://orcid.org/0000-0002-0973-943X, Rodgers, A ; https://orcid.org/0000-0003-1282-1896, Salam, A, Thom, S, Webster, R ; https://orcid.org/0000-0002-5136-1098, Johnson, C ; https://orcid.org/0000-0002-1497-7651, Krishnan, A, Mohan, S, Neal, B ; https://orcid.org/0000-0002-0490-7465, Reddy, KS, Shivashankar, R, Sudhir, T, Faletoese, S, Ieremia, M, Moodie, M, Pillay, A, Schultz, J, Siitia, J, Snowdon, W, Sukhu, A, Ulberg, C, Viali, S, Webster, J ; https://orcid.org/0000-0003-3513-3340, Bernabe-Ortiz, A, Cárdenas, MK, Diez-Canseco, F, Gilman, RH, Mohammad, Mohammad ; https://orcid.org/0000-0002-5870-7936, W.Tobe, S, Attaran, A, de Villiers, A, Featherstone, A, Forrest, J, Kalyesubula, R, Kamwesiga, J, Kengne, AP, Lopez, PC, Mills, E, Mukasa, B, Muldoon, K, Tayari, JC, Yaya, S, Kien Keat, N, Casas, JL, McCready, T, McKee, M, Ng, E, Nieuwlaat, R, Zainal, AO, Yusoff, K, Yusuf, S, Campbell, N, Kilonzo, K, Liu, P, Marr, M, Yeates, K, Feng, X, He, F, Jan, S ; https://orcid.org/0000-0003-2839-1405, Li, X ; https://orcid.org/0000-0001-5445-4022, Lin, CP, Ma, J, Ma, Y, MacGregor, G, Nowson, C, Wang, H, Wu, Y, Yan, L, Yuan, J, Zhang, J, Goudge, J, Kabudula, C, Limbani, F, Masilela, N, Myakayaka, N, Thorogood, M, Gómez-Olivé, FX, Arabshahi, S, Chow, C, Evans, R, Joshi, R ; https://orcid.org/0000-0002-3374-401X, Kalyanram, K, Kartik, K, Mahal, A, Maulik, P ; https://orcid.org/0000-0001-6835-6175, Oldenburg, B, Riddell, M ; https://orcid.org/0000-0001-8852-0569, Srikanth, V, Suresh, O, Thankappan, K, Thirunavukkarasu, S, Thomas, N, Thrift, AG, Varma, R, Clifford, G, Heritier, S, MacMahon, S ; https://orcid.org/0000-0003-2064-7699, Patel, A ; https://orcid.org/0000-0003-3825-4092, Peiris, D ; https://orcid.org/0000-0002-6898-3870, Prabhakaran, D, Praveen, D ; https://orcid.org/0000-0002-0973-943X, Rodgers, A ; https://orcid.org/0000-0003-1282-1896, Salam, A, Thom, S, Webster, R ; https://orcid.org/0000-0002-5136-1098, Johnson, C ; https://orcid.org/0000-0002-1497-7651, Krishnan, A, Mohan, S, Neal, B ; https://orcid.org/0000-0002-0490-7465, Reddy, KS, Shivashankar, R, Sudhir, T, Faletoese, S, Ieremia, M, Moodie, M, Pillay, A, Schultz, J, Siitia, J, Snowdon, W, Sukhu, A, Ulberg, C, Viali, S, Webster, J ; https://orcid.org/0000-0003-3513-3340, Bernabe-Ortiz, A, Cárdenas, MK, Diez-Canseco, F, Gilman, RH, and Mohammad, Mohammad ; https://orcid.org/0000-0002-5870-7936
- Published
- 2016
9. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
- Author
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Bryant, J.M., Grogono, D.M., Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jönsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., Ingen, J. van, Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., Floto, R.A., Bryant, J.M., Grogono, D.M., Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jönsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., Ingen, J. van, Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., and Floto, R.A.
- Abstract
Item does not contain fulltext
- Published
- 2016
10. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
- Author
-
Bryant, J.M., Grogono, D.M., Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jönsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., Ingen, J. van, Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., Floto, R.A., Bryant, J.M., Grogono, D.M., Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jönsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., Ingen, J. van, Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., and Floto, R.A.
- Abstract
Item does not contain fulltext
- Published
- 2016
11. Behaviour change strategies for reducing blood pressure-related disease burden: Findings from a global implementation research programme
- Author
-
Peiris, D ; https://orcid.org/0000-0002-6898-3870, Thompson, SR, Beratarrechea, A, Cárdenas, MK, Diez-Canseco, F, Goudge, J, Gyamfi, J, Kamano, JH, Irazola, V, Johnson, C ; https://orcid.org/0000-0002-1497-7651, Kengne, AP, Keat, NK, Miranda, JJ, Mohan, S, Mukasa, B, Ng, E, Nieuwlaat, R, Ogedegbe, O, Ovbiagele, B, Plange-Rhule, J, Praveen, D ; https://orcid.org/0000-0002-0973-943X, Salam, A, Thorogood, M, Thrift, AG, Vedanthan, R, Waddy, SP, Webster, J ; https://orcid.org/0000-0003-3513-3340, Webster, R ; https://orcid.org/0000-0002-5136-1098, Yeates, K, Yusoff, K, Featherstone, A, McCready, T, Jan, S ; https://orcid.org/0000-0003-2839-1405, Chow, C, Neal, B ; https://orcid.org/0000-0002-0490-7465, Gómez-Olivé, FX, Myakayaka, N, Kabudula, C, Limbani, F, Masilela, N, Thorogoo, M, Rodgers, A ; https://orcid.org/0000-0003-1282-1896, Stephen Jan, A, Joshi, R ; https://orcid.org/0000-0002-3374-401X, MacMahon, S ; https://orcid.org/0000-0003-2064-7699, Maulik, P ; https://orcid.org/0000-0001-6835-6175, Bernabe-Ortiz, A, Ponce-Lucero, V, Kimaiyo, S, Kofler, C, Gebregziabher, M, Warth, S, Attaran, A, Yaya, S, Mills, E, Muldoon, K, de Villiers, A, Forrest, J, Kalyesubula, R, Kamwesiga, J, Lopez, PC, Tayari, JC, Lopez, P, Casas, JL, McKee, M, Zainal, AO, Yusuf, S, Campbell, N, Kilonzo, K, Liu, P, Marr, M, Tobe, S, Feng, X, Yuan, J, He, F, MacGregor, G, Li, X ; https://orcid.org/0000-0001-5445-4022, Wu, Y, Yan, L, Lin, CP, Zhang, J, Ma, J, Ma, Y, Wang, H, Nowson, C, Moodie, M, Kalyanram, K, Kartik, K, Sudhir, T, Evans, R, Arabshahi, S, Mahal, A, Heritier, S, Oldenburg, B, Riddell, M ; https://orcid.org/0000-0001-8852-0569, Srikanth, V, Suresh, O, Thankappan, K, Mohammad, Mohammad ; https://orcid.org/0000-0002-5870-7936, Peiris, D ; https://orcid.org/0000-0002-6898-3870, Thompson, SR, Beratarrechea, A, Cárdenas, MK, Diez-Canseco, F, Goudge, J, Gyamfi, J, Kamano, JH, Irazola, V, Johnson, C ; https://orcid.org/0000-0002-1497-7651, Kengne, AP, Keat, NK, Miranda, JJ, Mohan, S, Mukasa, B, Ng, E, Nieuwlaat, R, Ogedegbe, O, Ovbiagele, B, Plange-Rhule, J, Praveen, D ; https://orcid.org/0000-0002-0973-943X, Salam, A, Thorogood, M, Thrift, AG, Vedanthan, R, Waddy, SP, Webster, J ; https://orcid.org/0000-0003-3513-3340, Webster, R ; https://orcid.org/0000-0002-5136-1098, Yeates, K, Yusoff, K, Featherstone, A, McCready, T, Jan, S ; https://orcid.org/0000-0003-2839-1405, Chow, C, Neal, B ; https://orcid.org/0000-0002-0490-7465, Gómez-Olivé, FX, Myakayaka, N, Kabudula, C, Limbani, F, Masilela, N, Thorogoo, M, Rodgers, A ; https://orcid.org/0000-0003-1282-1896, Stephen Jan, A, Joshi, R ; https://orcid.org/0000-0002-3374-401X, MacMahon, S ; https://orcid.org/0000-0003-2064-7699, Maulik, P ; https://orcid.org/0000-0001-6835-6175, Bernabe-Ortiz, A, Ponce-Lucero, V, Kimaiyo, S, Kofler, C, Gebregziabher, M, Warth, S, Attaran, A, Yaya, S, Mills, E, Muldoon, K, de Villiers, A, Forrest, J, Kalyesubula, R, Kamwesiga, J, Lopez, PC, Tayari, JC, Lopez, P, Casas, JL, McKee, M, Zainal, AO, Yusuf, S, Campbell, N, Kilonzo, K, Liu, P, Marr, M, Tobe, S, Feng, X, Yuan, J, He, F, MacGregor, G, Li, X ; https://orcid.org/0000-0001-5445-4022, Wu, Y, Yan, L, Lin, CP, Zhang, J, Ma, J, Ma, Y, Wang, H, Nowson, C, Moodie, M, Kalyanram, K, Kartik, K, Sudhir, T, Evans, R, Arabshahi, S, Mahal, A, Heritier, S, Oldenburg, B, Riddell, M ; https://orcid.org/0000-0001-8852-0569, Srikanth, V, Suresh, O, Thankappan, K, and Mohammad, Mohammad ; https://orcid.org/0000-0002-5870-7936
- Abstract
Background: The Global Alliance for Chronic Diseases comprises the majority of the world's public research funding agencies. It is focussed on implementation research to tackle the burden of chronic diseases in low- and middle-income countries and amongst vulnerable populations in high-income countries. In its inaugural research call, 15 projects were funded, focussing on lowering blood pressure-related disease burden. In this study, we describe a reflexive mapping exercise to identify the behaviour change strategies undertaken in each of these projects. Methods: Using the Behaviour Change Wheel framework, each team rated the capability, opportunity and motivation of the various actors who were integral to each project (e.g. community members, non-physician health workers and doctors in projects focussed on service delivery). Teams then mapped the interventions they were implementing and determined the principal policy categories in which those interventions were operating. Guidance was provided on the use of Behaviour Change Wheel to support consistency in responses across teams. Ratings were iteratively discussed and refined at several group meetings. Results: There was marked variation in the perceived capabilities, opportunities and motivation of the various actors who were being targeted for behaviour change strategies. Despite this variation, there was a high degree of synergy in interventions functions with most teams utilising complex interventions involving education, training, enablement, environmental restructuring and persuasion oriented strategies. Similar policy categories were also targeted across teams particularly in the areas of guidelines, communication/marketing and service provision with few teams focussing on fiscal measures, regulation and legislation. Conclusions: The large variation in preparedness to change behaviour amongst the principal actors across these projects suggests that the interventions themselves will be variably taken up, desp
- Published
- 2015
12. Protocol for developing the evidence base for a national salt reduction programme for India
- Author
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Johnson, C ; https://orcid.org/0000-0002-1497-7651, Mohan, S, Praveen, D ; https://orcid.org/0000-0002-0973-943X, Woodward, M ; https://orcid.org/0000-0001-9800-5296, Maulik, PK ; https://orcid.org/0000-0001-6835-6175, Shivashankar, R, Amarchand, R, Webster, J ; https://orcid.org/0000-0003-3513-3340, Dunford, E ; https://orcid.org/0000-0003-4505-3256, Thout, SR, MacGregor, G, He, F, Srinath Reddy, K, Krishnan, A, Prabhakaran, D, Neal, B ; https://orcid.org/0000-0002-0490-7465, Johnson, C ; https://orcid.org/0000-0002-1497-7651, Mohan, S, Praveen, D ; https://orcid.org/0000-0002-0973-943X, Woodward, M ; https://orcid.org/0000-0001-9800-5296, Maulik, PK ; https://orcid.org/0000-0001-6835-6175, Shivashankar, R, Amarchand, R, Webster, J ; https://orcid.org/0000-0003-3513-3340, Dunford, E ; https://orcid.org/0000-0003-4505-3256, Thout, SR, MacGregor, G, He, F, Srinath Reddy, K, Krishnan, A, Prabhakaran, D, and Neal, B ; https://orcid.org/0000-0002-0490-7465
- Abstract
Introduction: The scientific evidence base in support of salt reduction is strong but the data required to translate these insights into reduced population salt intake are mostly absent. The aim of this research project is to develop the evidence base required to formulate and implement a national salt reduction programme for India.
- Published
- 2014
13. Performance of the LHCb Vertex Locator
- Author
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LHCb VELO Group, Aaij, R., Affolder, A., Akiba, K., Alexander, M., Ali, S., Appleby, R. B., Artuso, M., Bates, A., Bay, A., Behrendt, O., Benton, J., van Beuzekom, M., Bjørnstad, P. M., Bogdanova, G., Borghi, S., Borgia, A., Bowcock, T. J. V., Brand, J. van den, Brown, H., Buytaert, J., Callot, O., Carroll, J., Casse, G., Collins, P., De Capua, S., Doets, M., Donleavy, S., Dossett, D., Dumps, R., Eckstein, D., Eklund, L., Farinelli, C., Farry, S., Ferro-Luzzi, M., Frei, R., Garofoli, J., Gersabeck, M., Gershon, T., Gong, A., Gong, H., Gordon, H., Haefeli, G., Harrison, J., Heijne, V., Hennessy, K., Hulsbergen, W., Huse, T., Hutchcroft, D., Jaeger, A., Jalocha, P., Jans, E., John, M., Keaveney, J., Ketel, T., Korolev, M., Kraan, M., Laštovička, T., Lafferty, G., Latham, T., Lefeuvre, G., Leflat, A., Liles, M., van Lysebetten, A., MacGregor, G., Marinho, F., McNulty, R., Merkin, M., Moran, D., Mountain, R., Mous, I., Mylroie-Smith, J., Needham, M., Nikitin, N., Noor, A., Oblakowska-Mucha, A., Papadelis, A., Pappagallo, M., Parkes, C., Patel, G. D., Rakotomiaramanana, B., Redford, S., Reid, M., Rinnert, K., Rodrigues, E., Saavedra, A. F., Schiller, M., Schneider, O., Shears, T., Coutinho, R. Silva, Smith, N. A., Szumlak, T., Thomas, C., van Tilburg, J., Tobin, M., Velthuis, J., Verlaat, B., Viret, S., Volkov, V., Wallace, C., Wang, J., Webber, A., Whitehead, M., Zverev, E., LHCb VELO Group, Aaij, R., Affolder, A., Akiba, K., Alexander, M., Ali, S., Appleby, R. B., Artuso, M., Bates, A., Bay, A., Behrendt, O., Benton, J., van Beuzekom, M., Bjørnstad, P. M., Bogdanova, G., Borghi, S., Borgia, A., Bowcock, T. J. V., Brand, J. van den, Brown, H., Buytaert, J., Callot, O., Carroll, J., Casse, G., Collins, P., De Capua, S., Doets, M., Donleavy, S., Dossett, D., Dumps, R., Eckstein, D., Eklund, L., Farinelli, C., Farry, S., Ferro-Luzzi, M., Frei, R., Garofoli, J., Gersabeck, M., Gershon, T., Gong, A., Gong, H., Gordon, H., Haefeli, G., Harrison, J., Heijne, V., Hennessy, K., Hulsbergen, W., Huse, T., Hutchcroft, D., Jaeger, A., Jalocha, P., Jans, E., John, M., Keaveney, J., Ketel, T., Korolev, M., Kraan, M., Laštovička, T., Lafferty, G., Latham, T., Lefeuvre, G., Leflat, A., Liles, M., van Lysebetten, A., MacGregor, G., Marinho, F., McNulty, R., Merkin, M., Moran, D., Mountain, R., Mous, I., Mylroie-Smith, J., Needham, M., Nikitin, N., Noor, A., Oblakowska-Mucha, A., Papadelis, A., Pappagallo, M., Parkes, C., Patel, G. D., Rakotomiaramanana, B., Redford, S., Reid, M., Rinnert, K., Rodrigues, E., Saavedra, A. F., Schiller, M., Schneider, O., Shears, T., Coutinho, R. Silva, Smith, N. A., Szumlak, T., Thomas, C., van Tilburg, J., Tobin, M., Velthuis, J., Verlaat, B., Viret, S., Volkov, V., Wallace, C., Wang, J., Webber, A., Whitehead, M., and Zverev, E.
- Abstract
The Vertex Locator (VELO) is a silicon microstrip detector that surrounds the proton-proton interaction region in the LHCb experiment. The performance of the detector during the first years of its physics operation is reviewed. The system is operated in vacuum, uses a bi-phase CO2 cooling system, and the sensors are moved to 7 mm from the LHC beam for physics data taking. The performance and stability of these characteristic features of the detector are described, and details of the material budget are given. The calibration of the timing and the data processing algorithms that are implemented in FPGAs are described. The system performance is fully characterised. The sensors have a signal to noise ratio of approximately 20 and a best hit resolution of 4 microns is achieved at the optimal track angle. The typical detector occupancy for minimum bias events in standard operating conditions in 2011 is around 0.5%, and the detector has less than 1% of faulty strips. The proximity of the detector to the beam means that the inner regions of the n+-on-n sensors have undergone space-charge sign inversion due to radiation damage. The VELO performance parameters that drive the experiment's physics sensitivity are also given. The track finding efficiency of the VELO is typically above 98% and the modules have been aligned to a precision of 1 micron for translations in the plane transverse to the beam. A primary vertex resolution of 13 microns in the transverse plane and 71 microns along the beam axis is achieved for vertices with 25 tracks. An impact parameter resolution of less than 35 microns is achieved for particles with transverse momentum greater than 1 GeV/c., Comment: 61 pages, 33 figures Minor typographical changes made during journal review are implemented in this version
- Published
- 2014
- Full Text
- View/download PDF
14. The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2
- Author
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Navarro, S. J, Navarro, S. J, Trinh, T., Lucas, C. A, Ross, A. J, Waymire, K. G, MacGregor, G. R, Threadgill, D. W, Navarro, S. J, Navarro, S. J, Trinh, T., Lucas, C. A, Ross, A. J, Waymire, K. G, MacGregor, G. R, and Threadgill, D. W
- Published
- 2012
15. The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2
- Author
-
Navarro, S. J, Navarro, S. J, Trinh, T., Lucas, C. A, Ross, A. J, Waymire, K. G, MacGregor, G. R, Threadgill, D. W, Navarro, S. J, Navarro, S. J, Trinh, T., Lucas, C. A, Ross, A. J, Waymire, K. G, MacGregor, G. R, and Threadgill, D. W
- Published
- 2012
16. Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies
- Author
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He, F.J., Nowson, Caryl, Lucas, M., MacGregor, G., He, F.J., Nowson, Caryl, Lucas, M., and MacGregor, G.
- Abstract
Increased consumption of fruit and vegetables has been shown to be associated with a reduced risk of coronary heart disease (CHD) in many epidemiological studies, however, the extent of the association is uncertain. We quantitatively assessed the relation between fruit and vegetable intake and incidence of CHD by carrying out a meta-analysis of cohort studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence interval (CI) of CHD with respect to frequency of fruit and vegetable intake. Twelve studies, consisting of 13 independent cohorts, met the inclusion criteria. There were 278 459 individuals (9143 CHD events) with a median follow-up of 11 years. Compared with individuals who had less than 3 servings/day of fruit and vegetables, the pooled RR of CHD was 0.93 (95% CI: 0.86–1.00, P=0.06) for those with 3–5 servings/day and 0.83 (0.77–0.89, P<0.0001) for those with more than 5 servings/day. Subgroup analyses showed that both fruits and vegetables had a significant protective effect on CHD. Our meta-analysis of prospective cohort studies demonstrates that increased consumption of fruit and vegetables from less than 3 to more than 5 servings/day is related to a 17% reduction in CHD risk, whereas increased intake to 3–5 servings/day is associated with a smaller and borderline significant reduction in CHD risk. These results provide strong support for the recommendations to consume more than 5 servings/day of fruit and vegetables.
- Published
- 2007
17. Regulatory toxicology and pharmacology.
- Author
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Axelson, Olav, Balbus, JM, Cohen, G, Davis, D, Donnay, A, Doolittle, R, Duran, BM, Egilman, D, Epstein, SS, Goldman, L, Grandjean, P, Hansen, ES, Heltne, P, Huff, J, Infante, P, Jacobson, MF, Joshi, TK, LaDou, J, Landrigan, PJ, Lee, PR, Lockwood, AH, MacGregor, G, Melnick, R, Messing, K, Needleman, H, Ozonoff, D, Ravanesi, B, Richter, ED, Sass, J, Schubert, D, Suzuki, D, Teitelbaum, D, Temple, NJ, Terracini, B, Thompson, A, Tickner, J, Tomatis, L, Upton, AC, Whyatt, RM, Wigmore, D, Wilson, T, Wing, SB, Sharpe, VA, Axelson, Olav, Balbus, JM, Cohen, G, Davis, D, Donnay, A, Doolittle, R, Duran, BM, Egilman, D, Epstein, SS, Goldman, L, Grandjean, P, Hansen, ES, Heltne, P, Huff, J, Infante, P, Jacobson, MF, Joshi, TK, LaDou, J, Landrigan, PJ, Lee, PR, Lockwood, AH, MacGregor, G, Melnick, R, Messing, K, Needleman, H, Ozonoff, D, Ravanesi, B, Richter, ED, Sass, J, Schubert, D, Suzuki, D, Teitelbaum, D, Temple, NJ, Terracini, B, Thompson, A, Tickner, J, Tomatis, L, Upton, AC, Whyatt, RM, Wigmore, D, Wilson, T, Wing, SB, and Sharpe, VA
- Published
- 2003
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