Search

The development of nanobody research holds the potential to revolutionize targeted therapies. This study focuses on nanoparticles functionalized with recombinant Anti-HER2 nanobodies to specifically bind to cancer cells that overexpress HER2 receptors. Utilizing the high affinity and specificity of nanobodies, these nanoparticles are optimized to serve as precise tools for recognizing and adhering to cancer cells. This method not only facilitates the direct delivery of drugs to tumor sites but also minimizes damage to healthy tissues. This method involves constructing recombinant proteins with the 2Rb17c HER2 nanobody in the pRS-4420 vector and expressing the proteins in Saccharomyces cerevisiae. The recombinant nanobody proteins were successfully conjugated to nanoparticles. This study demonstrates the potential for future applications in targeting HER2-positive cells, offering promising prospects for enhanced binding efficacy in targeted therapies.

We present a novel framework to efficiently acquire near-planar anisotropic reflectance in a pixel-independent fashion, using a deep gated mixtureof-experts. While existing work employs a unified network to handle all possible input, our network automatically learns to condition on the input for enhanced reconstruction. We train a gating module to select one out of a number of specialized decoders for reflectance reconstruction, based on photometric measurements, essentially trading generality for quality. A common, pre-trained latent transform module is also appended to each decoder, to offset the burden of the increased number of decoders. In addition, the illumination conditions during acquisition can be jointly optimized. The effectiveness of our framework is validated on a wide variety of challenging samples using a near-field lightstage. Compared with the state-of-the-art technique, our results are improved at the same input bandwidth, and our bandwidth can be reduced to about 1/3 for equal-quality results.

We present a novel framework to learn to convert the per-pixel photometric information at each view into spatially distinctive and view-invariant low-level features, which can be plugged into existing multi-view stereo pipeline for enhanced 3D reconstruction. Both the illumination conditions during acquisition and the subsequent per-pixel feature transform can be jointly optimized in a differentiable fashion. Our framework automatically adapts to and makes efficient use of the geometric information available in different forms of input data. High-quality 3D reconstructions of a variety of challenging objects are demonstrated on the data captured with an illumination multiplexing device, as well as a point light. Our results compare favorably with state-of-the-art techniques. © 2021 IEEE

We present a novel framework to learn to convert the perpixel photometric information at each view into spatially distinctive and view-invariant low-level features, which can be plugged into existing multi-view stereo pipeline for enhanced 3D reconstruction. Both the illumination conditions during acquisition and the subsequent per-pixel feature transform can be jointly optimized in a differentiable fashion. Our framework automatically adapts to and makes efficient use of the geometric information available in different forms of input data. High-quality 3D reconstructions of a variety of challenging objects are demonstrated on the data captured with an illumination multiplexing device, as well as a point light. Our results compare favorably with state-of-the-art techniques.

The Directory of English/Chinese Names of Scholars in Chinese Studies was a by-product of the "Chinese Studies in North America - Research and Resources" project. It provides both the English and the Chinese names of scholars involved in Chinese Studies mainly in North America. The Chinese names for western scholars resulted from an extensive in the relevant literature and on the internet at appropriate sites to find and authenticate the Chinese names used by these scholars. Where we could not find the Chinese name adopted by a scholar, we have transliterated their name into Chinese characters using the standard reference book 英语姓名译名手册. It is hoped that this directory will be useful for people needing to search for the Chinese names used by western scholars, or for the standard transliterations of their names into Chinese characters. Corrections of inaccurate information and addition of new names of Chinese Studies scholars worldwide are welcome. For corrections, comments and updates, please send emails to Haihui Zhang (Librarian for Chinese studies at East Asian Library, University Library System at University of Pittsburgh) at haihuiz@pitt.edu.

The Directory of English/Chinese Names of Scholars in Chinese Studies was a by-product of the "Chinese Studies in North America - Research and Resources" project. It provides both the English and the Chinese names of scholars involved in Chinese Studies mainly in North America. The Chinese names for western scholars resulted from an extensive in the relevant literature and on the internet at appropriate sites to find and authenticate the Chinese names used by these scholars. Where we could not find the Chinese name adopted by a scholar, we have transliterated their name into Chinese characters using the standard reference book 英语姓名译名手册. It is hoped that this directory will be useful for people needing to search for the Chinese names used by western scholars, or for the standard transliterations of their names into Chinese characters. Corrections of inaccurate information and addition of new names of Chinese Studies scholars worldwide are welcome. For corrections, comments and updates, please send emails to Haihui Zhang (Librarian for Chinese studies at East Asian Library, University Library System at University of Pittsburgh) at haihuiz@pitt.edu.