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202 results on '"MORAN, C. A."'

1. First Constraints on the Epoch of Reionization Using the non-Gaussianity of the Kinematic Sunyaev-Zel{'}dovich Effect from the South Pole Telescope and {\it Herschel}-SPIRE Observations

Author: Raghunathan, S., Ade, P. A. R., Anderson, A. J., Ansarinejad, B., Archipley, M., Austermann, J. E., Balkenhol, L., Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bock, J., Bouchet, F. R., Bryant, L., Camphuis, E., Carlstrom, J. E., Cecil, T. W., Chang, C. L., Chaubal, P., Chiang, H. C., Chichura, P. M., Chou, T. -L., Citron, R., Coerver, A., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C., Dibert, K. R., Dobbs, M. A., Doussot, A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fichman, K., Foster, A., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., Ge, F., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guidi, F., Guns, S., Gupta, N., de Haan, T., Halverson, N. W., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Hrubes, J. D., Hryciuk, A., Huang, N., Hubmayr, J., Irwin, K. D., Kéruzoré, F., Knox, L., Korman, M., Kornoelje, K., Kuo, C. -L., Lee, A. T., Levy, K., Li, D., Lowitz, A. E., Lu, C., Maniyar, A., McMahon, J. J., Menanteau, F., Millea, M., Montgomery, J., Moran, C. Corbett, Nakato, Y., Natoli, T., Nibarger, J. P., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Phadke, K. A., Prabhu, K., Pryke, C., Quan, W., Rahimi, M., Rahlin, A., Reichardt, C. L., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Schiappucci, E., Sievers, C., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Trendafilova, C., Tucker, C., Umilta, C., Veach, T., Vieira, J. D., Viero, M. P., Wan, Y., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Young, M. R., Zebrowski, J. A., Zemcov, M., Raghunathan, S., Ade, P. A. R., Anderson, A. J., Ansarinejad, B., Archipley, M., Austermann, J. E., Balkenhol, L., Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bock, J., Bouchet, F. R., Bryant, L., Camphuis, E., Carlstrom, J. E., Cecil, T. W., Chang, C. L., Chaubal, P., Chiang, H. C., Chichura, P. M., Chou, T. -L., Citron, R., Coerver, A., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C., Dibert, K. R., Dobbs, M. A., Doussot, A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fichman, K., Foster, A., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., Ge, F., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guidi, F., Guns, S., Gupta, N., de Haan, T., Halverson, N. W., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Hrubes, J. D., Hryciuk, A., Huang, N., Hubmayr, J., Irwin, K. D., Kéruzoré, F., Knox, L., Korman, M., Kornoelje, K., Kuo, C. -L., Lee, A. T., Levy, K., Li, D., Lowitz, A. E., Lu, C., Maniyar, A., McMahon, J. J., Menanteau, F., Millea, M., Montgomery, J., Moran, C. Corbett, Nakato, Y., Natoli, T., Nibarger, J. P., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Phadke, K. A., Prabhu, K., Pryke, C., Quan, W., Rahimi, M., Rahlin, A., Reichardt, C. L., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Schiappucci, E., Sievers, C., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Trendafilova, C., Tucker, C., Umilta, C., Veach, T., Vieira, J. D., Viero, M. P., Wan, Y., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Young, M. R., Zebrowski, J. A., and Zemcov, M.
Abstract: We report results from an analysis aimed at detecting the trispectrum of the kinematic Sunyaev-Zel{'}dovich (kSZ) effect by combining data from the South Pole Telescope (SPT) and {\it Herschel}-SPIRE experiments over a 100 ${\rm deg}^{2}$ field. The SPT observations combine data from the previous and current surveys, namely SPTpol and SPT-3G, to achieve depths of 4.5, 3, and 16 $\mu {\rm K-arcmin}$ in bands centered at 95, 150, and 220 GHz. For SPIRE, we include data from the 600 and 857 GHz bands. We reconstruct the velocity-induced large-scale correlation of the small-scale kSZ signal with a quadratic estimator that uses two cosmic microwave background (CMB) temperature maps, constructed by optimally combining data from all the frequency bands. We reject the null hypothesis of a zero trispectrum at $10.3\sigma$ level. However, the measured trispectrum contains contributions from both the kSZ and other undesired components, such as CMB lensing and astrophysical foregrounds, with kSZ being sub-dominant. We use the \textsc{Agora} simulations to estimate the expected signal from CMB lensing and astrophysical foregrounds. After accounting for the contributions from CMB lensing and foreground signals, we do not detect an excess kSZ-only trispectrum and use this non-detection to set constraints on reionization. By applying a prior based on observations of the Gunn-Peterson trough, we obtain an upper limit on the duration of reionization of $\Delta z_{\rm re, 50} < 4.5$ (95\% C.L). We find these constraints are fairly robust to foregrounds assumptions. This trispectrum measurement is independent of, but consistent with, {\it Planck}'s optical depth measurement. This result is the first constraint on the epoch of reionization using the non-Gaussian nature of the kSZ signal., Comment: 15 pages, 5 figures (3 in main text and 2 in Appendix); To be submitted to PRL; Comments welcome; Data products and plotting scripts can be downloaded from https://github.com/sriniraghunathan/kSZ_4pt_SPT_SPIRE
Published: 2024

2. SPT Clusters with DES and HST Weak Lensing. II. Cosmological Constraints from the Abundance of Massive Halos

Author: Bocquet, S., Grandis, S., Bleem, L. E., Klein, M., Mohr, J. J., Schrabback, T., Abbott, T. M. C., Ade, P. A. R., Aguena, M., Alarcon, A., Allam, S., Allen, S. W., Alves, O., Amon, A., Anderson, A. J., Annis, J., Ansarinejad, B., Austermann, J. E., Avila, S., Bacon, D., Bayliss, M., Beall, J. A., Bechtol, K., Becker, M. R., Bender, A. N., Benson, B. A., Bernstein, G. M., Bhargava, S., Bianchini, F., Brodwin, M., Brooks, D., Bryant, L., Campos, A., Canning, R. E. A., Carlstrom, J. E., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Cawthon, R., Chang, C. L., Chang, C., Chaubal, P., Chen, R., Chiang, H. C., Choi, A., Chou, T-L., Citron, R., Moran, C. Corbett, Cordero, J., Costanzi, M., Crawford, T. M., Crites, A. T., da Costa, L. N., Pereira, M. E. S., Davis, C., Davis, T. M., DeRose, J., Desai, S., de Haan, T., Diehl, H. T., Dobbs, M. A., Dodelson, S., Doux, C., Drlica-Wagner, A., Eckert, K., Elvin-Poole, J., Everett, S., Everett, W., Ferrero, I., Ferté, A., Flores, A. M., Frieman, J., Gallicchio, J., García-Bellido, J., Gatti, M., George, E. M., Giannini, G., Gladders, M. D., Gruen, D., Gruendl, R. A., Gupta, N., Gutierrez, G., Halverson, N. W., Harrison, I., Hartley, W. G., Herner, K., Hinton, S. R., Holder, G. P., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Huff, E. M., Huterer, D., Irwin, K. D., James, D. J., Jarvis, M., Khullar, G., Kim, K., Knox, L., Kraft, R., Krause, E., Kuehn, K., Kuropatkin, N., Kéruzoré, F., Lahav, O., Lee, A. T., Leget, P. -F., Li, D., Lin, H., Lowitz, A., MacCrann, N., Mahler, G., Mantz, A., Marshall, J. L., McCullough, J., McDonald, M., McMahon, J. J., Mena-Fernández, J., Menanteau, F., Meyer, S. S., Miquel, R., Montgomery, J., Myles, J., Natoli, T., Navarro-Alsina, A., Nibarger, J. P., Noble, G. I., Novosad, V., Ogando, R. L. C., Omori, Y., Padin, S., Pandey, S., Paschos, P., Patil, S., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Prat, J., Pryke, C., Raveri, M., Reichardt, C. L., Roberson, J., Rollins, R. P., Romero, C., Roodman, A., Ruhl, J. E., Rykoff, E. S., Saliwanchik, B. R., Salvati, L., Sánchez, C., Sanchez, E., Cid, D. Sanchez, Saro, A., Schaffer, K. K., Secco, L. F., Sevilla-Noarbe, I., Sharon, K., Sheldon, E., Shin, T., Sievers, C., Smecher, G., Smith, M., Somboonpanyakul, T., Sommer, M., Stalder, B., Stark, A. A., Stephen, J., Strazzullo, V., Suchyta, E., Tarle, G., To, C., Troxel, M. A., Tucker, C., Tutusaus, I., Varga, T. N., Veach, T., Vieira, J. D., Vikhlinin, A., von der Linden, A., Wang, G., Weaverdyck, N., Weller, J., Whitehorn, N., Wu, W. L. K., Yanny, B., Yefremenko, V., Yin, B., Young, M., Zebrowski, J. A., Zhang, Y., Zohren, H., Zuntz, J., Bocquet, S., Grandis, S., Bleem, L. E., Klein, M., Mohr, J. J., Schrabback, T., Abbott, T. M. C., Ade, P. A. R., Aguena, M., Alarcon, A., Allam, S., Allen, S. W., Alves, O., Amon, A., Anderson, A. J., Annis, J., Ansarinejad, B., Austermann, J. E., Avila, S., Bacon, D., Bayliss, M., Beall, J. A., Bechtol, K., Becker, M. R., Bender, A. N., Benson, B. A., Bernstein, G. M., Bhargava, S., Bianchini, F., Brodwin, M., Brooks, D., Bryant, L., Campos, A., Canning, R. E. A., Carlstrom, J. E., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Cawthon, R., Chang, C. L., Chang, C., Chaubal, P., Chen, R., Chiang, H. C., Choi, A., Chou, T-L., Citron, R., Moran, C. Corbett, Cordero, J., Costanzi, M., Crawford, T. M., Crites, A. T., da Costa, L. N., Pereira, M. E. S., Davis, C., Davis, T. M., DeRose, J., Desai, S., de Haan, T., Diehl, H. T., Dobbs, M. A., Dodelson, S., Doux, C., Drlica-Wagner, A., Eckert, K., Elvin-Poole, J., Everett, S., Everett, W., Ferrero, I., Ferté, A., Flores, A. M., Frieman, J., Gallicchio, J., García-Bellido, J., Gatti, M., George, E. M., Giannini, G., Gladders, M. D., Gruen, D., Gruendl, R. A., Gupta, N., Gutierrez, G., Halverson, N. W., Harrison, I., Hartley, W. G., Herner, K., Hinton, S. R., Holder, G. P., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Huff, E. M., Huterer, D., Irwin, K. D., James, D. J., Jarvis, M., Khullar, G., Kim, K., Knox, L., Kraft, R., Krause, E., Kuehn, K., Kuropatkin, N., Kéruzoré, F., Lahav, O., Lee, A. T., Leget, P. -F., Li, D., Lin, H., Lowitz, A., MacCrann, N., Mahler, G., Mantz, A., Marshall, J. L., McCullough, J., McDonald, M., McMahon, J. J., Mena-Fernández, J., Menanteau, F., Meyer, S. S., Miquel, R., Montgomery, J., Myles, J., Natoli, T., Navarro-Alsina, A., Nibarger, J. P., Noble, G. I., Novosad, V., Ogando, R. L. C., Omori, Y., Padin, S., Pandey, S., Paschos, P., Patil, S., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Prat, J., Pryke, C., Raveri, M., Reichardt, C. L., Roberson, J., Rollins, R. P., Romero, C., Roodman, A., Ruhl, J. E., Rykoff, E. S., Saliwanchik, B. R., Salvati, L., Sánchez, C., Sanchez, E., Cid, D. Sanchez, Saro, A., Schaffer, K. K., Secco, L. F., Sevilla-Noarbe, I., Sharon, K., Sheldon, E., Shin, T., Sievers, C., Smecher, G., Smith, M., Somboonpanyakul, T., Sommer, M., Stalder, B., Stark, A. A., Stephen, J., Strazzullo, V., Suchyta, E., Tarle, G., To, C., Troxel, M. A., Tucker, C., Tutusaus, I., Varga, T. N., Veach, T., Vieira, J. D., Vikhlinin, A., von der Linden, A., Wang, G., Weaverdyck, N., Weller, J., Whitehorn, N., Wu, W. L. K., Yanny, B., Yefremenko, V., Yin, B., Young, M., Zebrowski, J. A., Zhang, Y., Zohren, H., and Zuntz, J.
Abstract: We present cosmological constraints from the abundance of galaxy clusters selected via the thermal Sunyaev-Zel'dovich (SZ) effect in South Pole Telescope (SPT) data with a simultaneous mass calibration using weak gravitational lensing data from the Dark Energy Survey (DES) and the Hubble Space Telescope (HST). The cluster sample is constructed from the combined SPT-SZ, SPTpol ECS, and SPTpol 500d surveys, and comprises 1,005 confirmed clusters in the redshift range $0.25-1.78$ over a total sky area of 5,200 deg$^2$. We use DES Year 3 weak-lensing data for 688 clusters with redshifts $z<0.95$ and HST weak-lensing data for 39 clusters with $0.6
Published: 2024

3. Lower brain glucose metabolism in normal ageing is predominantly frontal and temporal: A systematic review and pooled effect size and activation likelihood estimates meta-analyses.

Author: Deery, HA, Di Paolo, R, Moran, C, Egan, GF, Jamadar, SD, Deery, HA, Di Paolo, R, Moran, C, Egan, GF, and Jamadar, SD
Abstract: This review provides a qualitative and quantitative analysis of cerebral glucose metabolism in ageing. We undertook a systematic literature review followed by pooled effect size and activation likelihood estimates (ALE) meta-analyses. Studies were retrieved from PubMed following the PRISMA guidelines. After reviewing 635 records, 21 studies with 22 independent samples (n = 911 participants) were included in the pooled effect size analyses. Eight studies with eleven separate samples (n = 713 participants) were included in the ALE analyses. Pooled effect sizes showed significantly lower cerebral metabolic rates of glucose for older versus younger adults for the whole brain, as well as for the frontal, temporal, parietal, and occipital lobes. Among the sub-cortical structures, the caudate showed a lower metabolic rate among older adults. In sub-group analyses controlling for changes in brain volume or partial volume effects, the lower glucose metabolism among older adults in the frontal lobe remained significant, whereas confidence intervals crossed zero for the other lobes and structures. The ALE identified nine clusters of lower glucose metabolism among older adults, ranging from 200 to 2640 mm3 . The two largest clusters were in the left and right inferior frontal and superior temporal gyri and the insula. Clusters were also found in the inferior temporal junction, the anterior cingulate and caudate. Taken together, the results are consistent with research showing less efficient glucose metabolism in the ageing brain. The findings are discussed in the context of theories of cognitive ageing and are compared to those found in neurodegenerative disease.
Published: 2023

4. Selenoprotein deficiency disorder predisposes to aortic aneurysm formation.

Author: Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, Wesley J., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J.C.M., Goddard, M., Nashef, S.A.M., Heijmen, R.H., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K., Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, Wesley J., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J.C.M., Goddard, M., Nashef, S.A.M., Heijmen, R.H., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., and Chatterjee, K.
Abstract: Contains fulltext : 300228.pdf (Publisher’s version ) (Open Access), Aortic aneurysms, which may dissect or rupture acutely and be lethal, can be a part of multisystem disorders that have a heritable basis. We report four patients with deficiency of selenocysteine-containing proteins due to selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2) mutations who show early-onset, progressive, aneurysmal dilatation of the ascending aorta due to cystic medial necrosis. Zebrafish and male mice with global or vascular smooth muscle cell (VSMC)-targeted disruption of Secisbp2 respectively show similar aortopathy. Aortas from patients and animal models exhibit raised cellular reactive oxygen species, oxidative DNA damage and VSMC apoptosis. Antioxidant exposure or chelation of iron prevents oxidative damage in patient's cells and aortopathy in the zebrafish model. Our observations suggest a key role for oxidative stress and cell death, including via ferroptosis, in mediating aortic degeneration.
Published: 2023

5. Simultaneous Millimeter-wave, Gamma-ray, and Optical Monitoring of the Blazar PKS 2326-502 During a Flaring State

Author: Hood II, J. C., Simpson, A., McDaniel, A., Foster, A., Ade, P. A. R., Ajello, M., Anderson, A. J., Austermann, J. E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T-L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gupta, N., Halverson, N. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Madejski, G., Malkan, M., McMahon, J. J., Meyer, S. S., Montgomery, J., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Smecher, G., Stark, A. A., Tucker, C., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Zebrowski, J. A., Zhang, L., Hood II, J. C., Simpson, A., McDaniel, A., Foster, A., Ade, P. A. R., Ajello, M., Anderson, A. J., Austermann, J. E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T-L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gupta, N., Halverson, N. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Madejski, G., Malkan, M., McMahon, J. J., Meyer, S. S., Montgomery, J., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Smecher, G., Stark, A. A., Tucker, C., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Zebrowski, J. A., and Zhang, L.
Abstract: Including millimeter-wave (mm-wave) data in multi-wavelength studies of the variability of active galactic nuclei (AGN) can provide insights into AGN physics that are not easily accessible at other wavelengths. We demonstrate in this work the potential of cosmic microwave background (CMB) telescopes to provide long-term, high-cadence mm-wave AGN monitoring over large fractions of sky. We report on a pilot study using data from the SPTpol instrument on the South Pole Telescope (SPT), which was designed to observe the CMB at arcminute and larger angular scales. Between 2013 and 2016, SPTpol was used primarily to observe a single 500 deg^2 field, covering the entire field several times per day with detectors sensitive to radiation in bands centered at 95 and 150 GHz. We use SPT 150 GHz observations to create AGN light curves, and we compare these mm-wave light curves to those at other wavelengths, in particular gamma-ray and optical. In this Letter, we focus on a single source, PKS 2326-502, which has extensive, day-timescale monitoring data in gamma-ray, optical, and now mm-wave between 2013 and 2016. We find PKS 2326-502 to be in a flaring state in the first two years of this monitoring, and we present a search for evidence of correlated variability between mm-wave, optical R band, and gamma-ray observations. This pilot study is paving the way for AGN monitoring with current and upcoming CMB experiments such as SPT-3G, Simons Observatory, and CMB-S4, including multi-wavelength studies with facilities such as VRO-LSST., Comment: 9 pages, 3 figures, accepted to Astrophysical Journal Letters
Published: 2023
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6. Galaxy Clusters Discovered via the Thermal Sunyaev-Zel'dovich Effect in the 500-square-degree SPTpol Survey

Author: Bleem, L. E., Klein, M., Abbott, T. M. C., Ade, P. A. R., Aguena, M., Alves, O., Anderson, A. J., Andrade-Oliveira, F., Ansarinejad, B., Archipley, M., Ashby, M. L. N., Austermann, J. E., Bacon, D., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bocquet, S., Brooks, D., Burke, D. L., Calzadilla, M., Carlstrom, J. E., Rosell, A. Carnero, Carretero, J., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T-L., Citron, R., Moran, C. Corbett, Costanzi, M., Crawford, T. M., Crites, A. T., da Costa, L. N., de Haan, T., De Vicente, J., Desai, S., Dobbs, M. A., Doel, P., Everett, W., Ferrero, I., Flaugher, B., Floyd, B., Friedel, D., Frieman, J., Gallicchio, J., Garc'ia-Bellido, J., Gatti, M., George, E. M., Giannini, G., Grandis, S., Gruen, D., Gruendl, R. A., Gupta, N., Gutierrez, G., Halverson, N. W., Hinton, S. R., Holder, G. P., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Mena-Fernández, J., James, D. J., Kéruzoré, F., Knox, L., Kuehn, K., Lahav, O., Lee, A. T., Lee, S., Li, D., Lowitz, A., Marshal, J. L., McDonald, M., McMahon, J. J., Menanteau, F., Meyer, S. S., Miquel, R., Mohr, J. J., Montgomery, J., Myles, J., Natoli, T., Nibarger, J. P., Noble, G. I., Novosad, V., Ogando, R. L. C., Padin, S., Patil, S., Pereira, M. E. S., Pieres, A., Malag'on, A. A. Plazas, Pryke, C., Reichardt, C. L., Rodr'iguez-Monroy, M., Romer, A. K., Ruhl, J. E., Saliwanchik, B. R., Salvati, L., Sanchez, E., Saro, A., Schaffer, K. K., Schrabback, T., Sevilla-Noarbe, I., Sievers, C., Smecher, G., Smith, M., Somboonpanyakul, T., Stalder, B., Stark, A. A., Suchyta, E., Swanson, M. E. C., Tarle, G., To, C., Tucker, C., Veach, T., Vieira, J. D., Vincenzi, M., Wang, G., Weller, J., Whitehorn, N., Wiseman, P., Wu, W. L. K., Yefremenko, V., Zebrowski, J. A., Zhang, Y., Bleem, L. E., Klein, M., Abbott, T. M. C., Ade, P. A. R., Aguena, M., Alves, O., Anderson, A. J., Andrade-Oliveira, F., Ansarinejad, B., Archipley, M., Ashby, M. L. N., Austermann, J. E., Bacon, D., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bocquet, S., Brooks, D., Burke, D. L., Calzadilla, M., Carlstrom, J. E., Rosell, A. Carnero, Carretero, J., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T-L., Citron, R., Moran, C. Corbett, Costanzi, M., Crawford, T. M., Crites, A. T., da Costa, L. N., de Haan, T., De Vicente, J., Desai, S., Dobbs, M. A., Doel, P., Everett, W., Ferrero, I., Flaugher, B., Floyd, B., Friedel, D., Frieman, J., Gallicchio, J., Garc'ia-Bellido, J., Gatti, M., George, E. M., Giannini, G., Grandis, S., Gruen, D., Gruendl, R. A., Gupta, N., Gutierrez, G., Halverson, N. W., Hinton, S. R., Holder, G. P., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Mena-Fernández, J., James, D. J., Kéruzoré, F., Knox, L., Kuehn, K., Lahav, O., Lee, A. T., Lee, S., Li, D., Lowitz, A., Marshal, J. L., McDonald, M., McMahon, J. J., Menanteau, F., Meyer, S. S., Miquel, R., Mohr, J. J., Montgomery, J., Myles, J., Natoli, T., Nibarger, J. P., Noble, G. I., Novosad, V., Ogando, R. L. C., Padin, S., Patil, S., Pereira, M. E. S., Pieres, A., Malag'on, A. A. Plazas, Pryke, C., Reichardt, C. L., Rodr'iguez-Monroy, M., Romer, A. K., Ruhl, J. E., Saliwanchik, B. R., Salvati, L., Sanchez, E., Saro, A., Schaffer, K. K., Schrabback, T., Sevilla-Noarbe, I., Sievers, C., Smecher, G., Smith, M., Somboonpanyakul, T., Stalder, B., Stark, A. A., Suchyta, E., Swanson, M. E. C., Tarle, G., To, C., Tucker, C., Veach, T., Vieira, J. D., Vincenzi, M., Wang, G., Weller, J., Whitehorn, N., Wiseman, P., Wu, W. L. K., Yefremenko, V., Zebrowski, J. A., and Zhang, Y.
Abstract: We present a catalog of 689 galaxy cluster candidates detected at significance $\xi>4$ via their thermal Sunyaev-Zel'dovich (SZ) effect signature in 95 and 150 GHz data from the 500-square-degree SPTpol survey. We use optical and infrared data from the Dark Energy Camera and the Wide-field Infrared Survey Explorer (WISE) and \spitzer \ satellites, to confirm 544 of these candidates as clusters with $\sim94\%$ purity. The sample has an approximately redshift-independent mass threshold at redshift $z>0.25$ and spans $1.5 \times 10^{14} < M_{500c} < 9.1 \times 10^{14}$ $M_\odot/h_{70}$ \ and $0.031$. We use external radio data from the Sydney University Molonglo Sky Survey (SUMSS) to estimate contamination to the SZ signal from synchrotron sources. The contamination reduces the recovered $\xi$ by a median value of 0.032, or $\sim0.8\%$ of the $\xi=4$ threshold value, and $\sim7\%$ of candidates have a predicted contamination greater than $\Delta \xi = 1$. With the exception of a small number of systems $(<1\%)$, an analysis of clusters detected in single-frequency 95 and 150 GHz data shows no significant contamination of the SZ signal by emission from dusty or synchrotron sources. This cluster sample will be a key component in upcoming astrophysical and cosmological analyses of clusters. The SPTpol millimeter-wave maps and associated data products used to produce this sample are available at https://pole.uchicago.edu/public/data/sptpol_500d_clusters/index.html, and the NASA LAMBDA website. An interactive sky server with the SPTpol maps and Dark Energy Survey data release 2 images is also available at NCSA https://skyviewer.ncsa.illinois.edu., Comment: Matches version accepted by OJA. 19 pages + references, 14 figures, cluster candidate table provided in Appendix. Data products available at https://pole.uchicago.edu/public/data/sptpol_500d_clusters/index.html and an interactive sky server at https://skyviewer.ncsa.illinois.edu
Published: 2023
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7. Asteroid Measurements at Millimeter Wavelengths with the South Pole Telescope

Author: Chichura, P. M., Foster, A., Patel, C., Ossa-Jaen, N., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Archipley, M., Austermann, J. E., Avva, J. S., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Chiang, H. C., Cho, H. -M., Chou, T-L., Citron, R., Cliche, J. -F., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C. M., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., de Haan, T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Lu, C., Marrone, D. P., McMahon, J. J., Meyer, S. S., Michalik, D., Millea, M., Mocanu, L. M., Montgomery, J., Moran, C. Corbett, Nadolski, A., Natoli, T., Nguyen, H., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Pearson, J., Phadke, K. A., Posada, C. M., Prabhu, K., Pryke, C., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Schiappucci, E., Shirokoff, E., Sievers, C., Smecher, G., Sobrin, J. A., Springmann, A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., Young, M. R., Chichura, P. M., Foster, A., Patel, C., Ossa-Jaen, N., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Archipley, M., Austermann, J. E., Avva, J. S., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Chiang, H. C., Cho, H. -M., Chou, T-L., Citron, R., Cliche, J. -F., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C. M., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., de Haan, T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Lu, C., Marrone, D. P., McMahon, J. J., Meyer, S. S., Michalik, D., Millea, M., Mocanu, L. M., Montgomery, J., Moran, C. Corbett, Nadolski, A., Natoli, T., Nguyen, H., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Pearson, J., Phadke, K. A., Posada, C. M., Prabhu, K., Pryke, C., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Schiappucci, E., Shirokoff, E., Sievers, C., Smecher, G., Sobrin, J. A., Springmann, A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
Abstract: We present the first measurements of asteroids in millimeter wavelength (mm) data from the South Pole Telescope (SPT), which is used primarily to study the cosmic microwave background (CMB). We analyze maps of two $\sim270$ deg$^2$ sky regions near the ecliptic plane, each observed with the SPTpol camera $\sim100$ times over one month. We subtract the mean of all maps of a given field, removing static sky signal, and then average the mean-subtracted maps at known asteroid locations. We detect three asteroids$\text{ -- }$(324) Bamberga, (13) Egeria, and (22) Kalliope$\text{ -- }$with signal-to-noise ratios (S/N) of 11.2, 10.4, and 6.1, respectively, at 2.0 mm (150 GHz); we also detect (324) Bamberga with S/N of 4.1 at 3.2 mm (95 GHz). We place constraints on these asteroids' effective emissivities, brightness temperatures, and light curve modulation amplitude. Our flux density measurements of (324) Bamberga and (13) Egeria roughly agree with predictions, while our measurements of (22) Kalliope suggest lower flux, corresponding to effective emissivities of $0.66 \pm 0.11$ at 2.0 mm and $<0.47$ at 3.2mm. We predict the asteroids detectable in other SPT datasets and find good agreement with detections of (772) Tanete and (1093) Freda in recent data from the SPT-3G camera, which has $\sim10 \times$ the mapping speed of SPTpol. This work is the first focused analysis of asteroids in data from CMB surveys, and it demonstrates we can repurpose historic and future datasets for asteroid studies. Future SPT measurements can help constrain the distribution of surface properties over a larger asteroid population., Comment: 21 pages, 9 figures, to be submitted to ApJ
Published: 2022

8. Frailty is associated with cognitive decline independent of cerebral small vessel disease and brain atrophy

Author: Siejka, TP, Srikanth, VK, Hubbard, RE, Moran, C, Beare, R, Wood, Amanda, Collyer, TA, Gujjari, S, Phan, TG, Callisaya, ML, Siejka, TP, Srikanth, VK, Hubbard, RE, Moran, C, Beare, R, Wood, Amanda, Collyer, TA, Gujjari, S, Phan, TG, and Callisaya, ML
Published: 2022

9. Frailty is associated with cognitive decline independent of cerebral small vessel disease and brain atrophy.

Author: Siejka T.P., Srikanth V.K., Hubbard R.E., Moran C., Beare R., Wood A.G., Collyer T.A., Gujjari S., Phan T.G., Callisaya M.L., Siejka T.P., Srikanth V.K., Hubbard R.E., Moran C., Beare R., Wood A.G., Collyer T.A., Gujjari S., Phan T.G., and Callisaya M.L.
Abstract: BACKGROUND: To examine the effect of frailty on cognitive decline independent of cerebral small vessel disease (cSVD) and brain atrophy, and whether associations between neuropathology and cognition differed depending on frailty status. METHOD(S): The Tasmanian Study of Cognition and Gait (TASCOG) was a population based longitudinal cohort study with data collected at three phases from 2005 to 2012. Participants aged 60-85, were randomly selected from the electoral roll. Various data were used to operationalize a 36-item Frailty Index (FI) at baseline. Brain MRI was undertaken to obtain baseline measures of neuropathology. A neuropsychological battery was used to assess cognition at each time point. Generalized linear mixed models were used to examine the effect of frailty and MRI measures on cognition over time. The associations between MRI measures and cognition were explored after stratifying the sample by baseline frailty status. All analyses were adjusted for age, sex and education. RESULT(S): A total of 385 participants were included at baseline. The mean age was 72.5 years (SD 7.0), 44% were female (n=171). In fully adjusted linear mixed models, frailty (FI x time beta -0.001, 95% CI -0.003, -0.001, p = 0.03) was associated with decline in global cognition, independent of brain atrophy and cSVD. The association between cSVD and global cognition was significant only in those with low levels of frailty (p=0.03). CONCLUSION(S): These findings suggest that frailty is an important factor in early cognitive dysfunction, and measuring frailty may prove useful to help identify future risk of cognitive decline.Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America.
Published: 2022

10. Frailty Is Associated With Cognitive Decline Independent of Cerebral Small Vessel Disease and Brain Atrophy.

Author: Siejka T.P., Srikanth V.K., Hubbard R.E., Moran C., Beare R., Wood A.G., Collyer T.A., Gujjari S., Phan T.G., Callisaya M.L., Siejka T.P., Srikanth V.K., Hubbard R.E., Moran C., Beare R., Wood A.G., Collyer T.A., Gujjari S., Phan T.G., and Callisaya M.L.
Abstract: BACKGROUND: To examine the effect of frailty on cognitive decline independent of cerebral small vessel disease (cSVD) and brain atrophy, and whether associations between neuropathology and cognition differed depending on frailty status. METHOD(S): The Tasmanian Study of Cognition and Gait was a population-based longitudinal cohort study with data collected at 3 phases from 2005 to 2012. Participants aged 60-85 were randomly selected from the electoral roll. Various data were used to operationalize a 36-item frailty index (FI) at baseline. Brain MRI was undertaken to obtain baseline measures of neuropathology. A neuropsychological battery was used to assess cognition at each time point. Generalized linear mixed models were used to examine the effect of frailty and MRI measures on cognition over time. The associations between MRI measures and cognition were explored after stratifying the sample by baseline frailty status. All analyses were adjusted for age, sex, and education. RESULT(S): A total of 385 participants were included at baseline. The mean age was 72.5 years (standard deviation [SD] 7.0), 44% were female (n = 171). In fully adjusted linear mixed models, frailty (FI x time beta -0.001, 95% confidence interval [CI] -0.003, -0.001, p = .03) was associated with decline in global cognition, independent of brain atrophy, and cSVD. The association between cSVD and global cognition was significant only in those with low levels of frailty (p = .03). CONCLUSION(S): These findings suggest that frailty is an important factor in early cognitive dysfunction, and measuring frailty may prove useful to help identify future risk of cognitive decline.Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America.
Published: 2022

11. Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study.

Author: van Geest, FS, Groeneweg, S, van den Akker, ELT, Bacos, I, Barca, D, van den Berg, SAA, Bertini, E, Brunner, D, Brunetti-Pierri, N, Cappa, M, Cappuccio, G, Chatterjee, K, Chesover, AD, Christian, P, Coutant, R, Craiu, D, Crock, P, Dewey, C, Dica, A, Dimitri, P, Dubey, R, Enderli, A, Fairchild, J, Gallichan, J, Garibaldi, LR, George, B, Hackenberg, A, Heinrich, B, Huynh, T, Kłosowska, A, Lawson-Yuen, A, Linder-Lucht, M, Lyons, G, Monti Lora, F, Moran, C, Müller, KE, Paone, L, Paul, PG, Polak, M, Porta, F, Reinauer, C, de Rijke, YB, Seckold, R, Menevşe, TS, Simm, P, Simon, A, Spada, M, Stoupa, A, Szeifert, L, Tonduti, D, van Toor, H, Turan, S, Vanderniet, J, de Waart, M, van der Wal, R, van der Walt, A, van Wermeskerken, A-M, Wierzba, J, Zibordi, F, Zung, A, Peeters, RP, Visser, WE, van Geest, FS, Groeneweg, S, van den Akker, ELT, Bacos, I, Barca, D, van den Berg, SAA, Bertini, E, Brunner, D, Brunetti-Pierri, N, Cappa, M, Cappuccio, G, Chatterjee, K, Chesover, AD, Christian, P, Coutant, R, Craiu, D, Crock, P, Dewey, C, Dica, A, Dimitri, P, Dubey, R, Enderli, A, Fairchild, J, Gallichan, J, Garibaldi, LR, George, B, Hackenberg, A, Heinrich, B, Huynh, T, Kłosowska, A, Lawson-Yuen, A, Linder-Lucht, M, Lyons, G, Monti Lora, F, Moran, C, Müller, KE, Paone, L, Paul, PG, Polak, M, Porta, F, Reinauer, C, de Rijke, YB, Seckold, R, Menevşe, TS, Simm, P, Simon, A, Spada, M, Stoupa, A, Szeifert, L, Tonduti, D, van Toor, H, Turan, S, Vanderniet, J, de Waart, M, van der Wal, R, van der Walt, A, van Wermeskerken, A-M, Wierzba, J, Zibordi, F, Zung, A, Peeters, RP, and Visser, WE
Abstract: CONTEXT: Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated with being underweight and having cardiovascular dysfunction. OBJECTIVE: Our previous trial showed improvement of key clinical and biochemical features during 1-year treatment with the T3 analogue Triac, but long-term follow-up data are needed. METHODS: In this real-life retrospective cohort study, we investigated the efficacy of Triac in MCT8-deficient patients in 33 sites. The primary endpoint was change in serum T3 concentrations from baseline to last available measurement. Secondary endpoints were changes in other thyroid parameters, anthropometric parameters, heart rate, and biochemical markers of thyroid hormone action. RESULTS: From October 15, 2014 to January 1, 2021, 67 patients (median baseline age 4.6 years; range, 0.5-66) were treated up to 6 years (median 2.2 years; range, 0.2-6.2). Mean T3 concentrations decreased from 4.58 (SD 1.11) to 1.66 (0.69) nmol/L (mean decrease 2.92 nmol/L; 95% CI, 2.61-3.23; P < 0.0001; target 1.4-2.5 nmol/L). Body-weight-for-age exceeded that of untreated historical controls (mean difference 0.72 SD; 95% CI, 0.36-1.09; P = 0.0002). Heart-rate-for-age decreased (mean difference 0.64 SD; 95% CI, 0.29-0.98; P = 0.0005). SHBG concentrations decreased from 245 (99) to 209 (92) nmol/L (mean decrease 36 nmol/L; 95% CI, 16-57; P = 0.0008). Mean creatinine concentrations increased from 32 (11) to 39 (13) µmol/L (mean increase 7 µmol/L; 95% CI, 6-9; P < 0.0001). Mean creatine kinase concentrations did not significantly change. No drug-related severe adverse events were reported. CONCLUSIONS: Key features were sustainably alleviated in patients with MCT8 deficiency across all ages, highlighting the real-life potential of Triac for MCT8 deficiency.
Published: 2022

12. Processes of Social Innovation in Housing (SI-H) in Latin America: an approach for the comparative analysis of innovative bottom-up housing claim practices

Author: VICARI, SERENA, MANZANO MORAN, C, D'OVIDIO, MARIANNA, MANZANO MORAN, CARLOS ALBERTO, VICARI, SERENA, MANZANO MORAN, C, D'OVIDIO, MARIANNA, and MANZANO MORAN, CARLOS ALBERTO
Abstract: L'accesso a un alloggio adeguato è stato riconosciuto come una condizione direttamente collegata al benessere umano, diventata purtroppo un bene strategico per il mercato finanziario globale, provocando tensioni strutturali che raggiungono il loro apice nei contesti urbani alla periferia dello sviluppo neoliberista. In America Latina, l’instabilità socio-politica, il pensiero progressista (ad esempio, le teorie della Teologia della Liberazione e della Pedagogia degli Oppressi), il know-how tradizionale, la solidarietà e il mutuo soccorso e il sincretismo locale-europeo, hanno creato le condizioni per una tradizione accumulata bottom-up di auto-fornitura di alloggi, dove le persone che sono sistematicamente oppresse ed escluse hanno (ri)rivendicato il diritto all'alloggio e si sono impegnate in progetti politici più ampi. Riguardo a questo, sono stati fatti notevoli sforzi per descrivere la tradizione empirica che si è accumulata, ma ciò che è carente è il tentativo di collegare tale tradizione alle teorie urbane e sociali. Pertanto, questa dissertazione contribuisce proponendo lenti concettuali per osservare e comparare esperienze empiriche locali, in modo che i dati possano essere raccolti su scala regionale e alla fine si possano tradurre tali osservazioni in teorie. Le condizioni abitative globali richiedono nuovi modi di pensare alla fornitura, alla gestione e al possesso di alloggi; quindi, dall'analisi di esperienze contro-egemoniche innovative si possono trarre lezioni preziose. Come metodologia è stata scelta l'analisi comparativa di casi studio e sono stati presi in considerazione alcuni principi derivanti da studi comparativi urbani postcoloniali. I casi di studio selezionati sono Sociedad Cooperativa de Vivienda Unión Palo Alto (Messico) e Asociación Cooperativa de Vivienda La Libertad 13 de Enero (El Salvador), entrambe hanno adattato i principi della rete uruguaiana di Cooperativismo de Vivienda por Ayuda Mutua (CVAM), che hanno ampliato in t, Access to adequate housing has been acknowledged as a condition directly linked to human well-being that has however become a strategic commodity for the global financial market, causing structural tensions that reach their apex in urban contexts on the periphery of the neoliberal development. In Latin America, neoliberal principles have been widely adopted, and urbanization dynamics have reproduced socio-spatial exclusion and inequality. However, socio-political turmoil, progressive thinking (e.g., theories of Liberation Theology and Pedagogy of the Oppressed), traditional know-how, solidarity and mutual-aid, and local-European syncretism, have created the conditions for an accumulated tradition of bottom-up housing self-provision, where people that are systematically oppressed and excluded have (re)claimed their right to housing and engaged in broader political projects. Since the 1970s in Latin America, exemplary practices of organized bottom-up housing claims have emerged, institutionalized, informed governance structures, and been impactful in terms of housing provision. Over this, considerable efforts for describing the accumulated empirical tradition have been done, but less in trying to link it with urban and social theories. Therefore, this dissertation contributes by proposing conceptual lenses for approaching and comparing local empirical experiences, so data can be collected at a regional scale, and theorization can eventually be produced. Global housing conditions demand new ways of thinking about housing provision, management, and tenure; hence, valuable lessons can be drawn from the analysis of innovative counter-hegemonic experiences. Comparative case study analysis has been selected as the methodology and some principles coming from post-colonial urban comparative studies are considered. The case studies selected are Sociedad Cooperativa de Vivienda Unión Palo Alto (Mexico) and Asociación Cooperativa de Vivienda La Libertad 13 de Enero (El Salvado
Published: 2022

13. Asteroid Measurements at Millimeter Wavelengths with the South Pole Telescope

Author: Chichura, P. M., Foster, A., Patel, C., Ossa-Jaen, N., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Archipley, M., Austermann, J. E., Avva, J. S., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Chiang, H. C., Cho, H. -M., Chou, T-L., Citron, R., Cliche, J. -F., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C. M., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., de Haan, T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Lu, C., Marrone, D. P., McMahon, J. J., Meyer, S. S., Michalik, D., Millea, M., Mocanu, L. M., Montgomery, J., Moran, C. Corbett, Nadolski, A., Natoli, T., Nguyen, H., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Pearson, J., Phadke, K. A., Posada, C. M., Prabhu, K., Pryke, C., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Schiappucci, E., Shirokoff, E., Sievers, C., Smecher, G., Sobrin, J. A., Springmann, A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., Young, M. R., Chichura, P. M., Foster, A., Patel, C., Ossa-Jaen, N., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Archipley, M., Austermann, J. E., Avva, J. S., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Chiang, H. C., Cho, H. -M., Chou, T-L., Citron, R., Cliche, J. -F., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C. M., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., de Haan, T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Lu, C., Marrone, D. P., McMahon, J. J., Meyer, S. S., Michalik, D., Millea, M., Mocanu, L. M., Montgomery, J., Moran, C. Corbett, Nadolski, A., Natoli, T., Nguyen, H., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Pearson, J., Phadke, K. A., Posada, C. M., Prabhu, K., Pryke, C., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Schiappucci, E., Shirokoff, E., Sievers, C., Smecher, G., Sobrin, J. A., Springmann, A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
Abstract: We present the first measurements of asteroids in millimeter wavelength (mm) data from the South Pole Telescope (SPT), which is used primarily to study the cosmic microwave background (CMB). We analyze maps of two $\sim270$ deg$^2$ sky regions near the ecliptic plane, each observed with the SPTpol camera $\sim100$ times over one month. We subtract the mean of all maps of a given field, removing static sky signal, and then average the mean-subtracted maps at known asteroid locations. We detect three asteroids$\text{ -- }$(324) Bamberga, (13) Egeria, and (22) Kalliope$\text{ -- }$with signal-to-noise ratios (S/N) of 11.2, 10.4, and 6.1, respectively, at 2.0 mm (150 GHz); we also detect (324) Bamberga with S/N of 4.1 at 3.2 mm (95 GHz). We place constraints on these asteroids' effective emissivities, brightness temperatures, and light curve modulation amplitude. Our flux density measurements of (324) Bamberga and (13) Egeria roughly agree with predictions, while our measurements of (22) Kalliope suggest lower flux, corresponding to effective emissivities of $0.66 \pm 0.11$ at 2.0 mm and $<0.47$ at 3.2mm. We predict the asteroids detectable in other SPT datasets and find good agreement with detections of (772) Tanete and (1093) Freda in recent data from the SPT-3G camera, which has $\sim10 \times$ the mapping speed of SPTpol. This work is the first focused analysis of asteroids in data from CMB surveys, and it demonstrates we can repurpose historic and future datasets for asteroid studies. Future SPT measurements can help constrain the distribution of surface properties over a larger asteroid population., Comment: 21 pages, 9 figures
Published: 2022
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14. Supplementary material to: Long-term efficacy of T3 analogue Triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study

Author: Geest, F.S. (Ferdy) van, Groeneweg, S. (Stefan), Akker, E.L.T. (Erica) van den, Bacos, I. (Iuliu), Barca, D. (Diana), Berg, S.A.A. (Sjoerd) van den, Bertini, E. (Enrico), Brunner, D. (Doris), Brunetti-Pierri, N. (Nicola), Cappa, M. (Marco), Cappuccio, G. (Gerarda), Chatterjee, K. (Krishna), Chesover, A.D. (Alexander), Christian, P. (Peter), Coutant, R. (Régis), Craiu, D. (Dana), Crock, P. (Patricia), Dewey, C. (Cheyenne), Dica, A. (Alice), Dimitri, P. (Paul), Dubey, R. (Rachana), Enderli, A. (Anina), Fairchild, J. (Jan), Gallichan, J. (Jonathan), Garibaldi, L.R. (Luigi), George, B. (Belinda), Hackenberg, A. (Annette), Heinrich, B. (Bianka), Huynh, Tony (T.), Klosowska, A. (Anna), Lawson-Yuen, A. (Amy), Linder-Lucht, M. (Michaela), Lyons, G. (Greta), Monti Lora, F. (Felipe), Moran, C. (Carla), Müller, K. (Katalin), Paone, L. (Laura), Paul, P.G. (Praveen), Polak, M. (Michel), Porta, F. (Francesco), Reinauer, C. (Christina), Rijke, Y.B. (Yolanda) de, Seckold, R. (Rowen), Seven Menevse, T. (Tuba), Simm, P. (Peter), Simon, A. (Anna), Spada, M. (Marco), Stoupa, A. (Athanasia), Szeifert, L. (Lilla), Tonduti, D. (Davide), Toor, H. (Hans) van, Turan, S. (Serap), Vanderniet, J. (Joel), Waart, M. (Monique) de, Wal, R. (Ronald) van der, Walt, A. (Adri) van der, Wermeskerken, A-M. (Anne-Marie) van, Wierzba, J. (Jolanta), Zibordi, F. (Federica), Zung, A. (Amnon), Peeters, R.P. (Robin), Visser, W.E. (Edward), Geest, F.S. (Ferdy) van, Groeneweg, S. (Stefan), Akker, E.L.T. (Erica) van den, Bacos, I. (Iuliu), Barca, D. (Diana), Berg, S.A.A. (Sjoerd) van den, Bertini, E. (Enrico), Brunner, D. (Doris), Brunetti-Pierri, N. (Nicola), Cappa, M. (Marco), Cappuccio, G. (Gerarda), Chatterjee, K. (Krishna), Chesover, A.D. (Alexander), Christian, P. (Peter), Coutant, R. (Régis), Craiu, D. (Dana), Crock, P. (Patricia), Dewey, C. (Cheyenne), Dica, A. (Alice), Dimitri, P. (Paul), Dubey, R. (Rachana), Enderli, A. (Anina), Fairchild, J. (Jan), Gallichan, J. (Jonathan), Garibaldi, L.R. (Luigi), George, B. (Belinda), Hackenberg, A. (Annette), Heinrich, B. (Bianka), Huynh, Tony (T.), Klosowska, A. (Anna), Lawson-Yuen, A. (Amy), Linder-Lucht, M. (Michaela), Lyons, G. (Greta), Monti Lora, F. (Felipe), Moran, C. (Carla), Müller, K. (Katalin), Paone, L. (Laura), Paul, P.G. (Praveen), Polak, M. (Michel), Porta, F. (Francesco), Reinauer, C. (Christina), Rijke, Y.B. (Yolanda) de, Seckold, R. (Rowen), Seven Menevse, T. (Tuba), Simm, P. (Peter), Simon, A. (Anna), Spada, M. (Marco), Stoupa, A. (Athanasia), Szeifert, L. (Lilla), Tonduti, D. (Davide), Toor, H. (Hans) van, Turan, S. (Serap), Vanderniet, J. (Joel), Waart, M. (Monique) de, Wal, R. (Ronald) van der, Walt, A. (Adri) van der, Wermeskerken, A-M. (Anne-Marie) van, Wierzba, J. (Jolanta), Zibordi, F. (Federica), Zung, A. (Amnon), Peeters, R.P. (Robin), and Visser, W.E. (Edward)
Published: 2021

15. Validation of the 'knowledge about melanoma early detection scale' in a sample of melanoma survivors

Author: Coroiu, A., Moran, C., Kwakkenbos, L., Thombs, B.D., Körner, A., Coroiu, A., Moran, C., Kwakkenbos, L., Thombs, B.D., and Körner, A.
Abstract: 29 januari 2021, Item does not contain fulltext, The purpose of this study was to describe the development and preliminary testing of a new scale assessing knowledge about melanoma risk factors and early detection/secondary prevention. Data was drawn from a longitudinal study assessing barriers and facilitators of skin self- examination among patients diagnosed with melanoma. For the current analysis, 191 patients who completed the new 9-item Knowledge About Melanoma Early Detection Scale and other study measures were included. Exploratory factor analysis with were conducted, which identified a robust scale comprised of 6 items with factor loadings ranging from .56 to .81. Higher scores on the Knowledge About Melanoma Early Detection Scale were associated with younger age and more positive attitudes about melanoma prevention, but not with biological sex, education, melanoma stage, or past self-administered and physician-provided skin checks. Further studies are needed to replicate these findings and to further establish the predictive validity of this scale and its usefulness for health research.
Published: 2021

16. Interactions between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study.

Author: Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., Callisaya M.L., Thomson R., Phan T.G., Fornito A., Srikanth V.K., Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., Callisaya M.L., Thomson R., Phan T.G., Fornito A., and Srikanth V.K.
Abstract: Objectives: Age and female sex are risk factors for dementia, and menopause is associated with cognitive dysfunction. Previous work largely considered the effects of sex and menopause as being independent of age. We studied whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife. Method(s): In this cross-sectional study of UK Biobank participants with brain magnetic resonance imaging (MRI), we explored the interaction of age with sex or menopausal status in explaining total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), white matter hyperintensity volume (WMHV), regional cortical volume, and subcortical volume. Result(s): Data were available for 1827 postmenopausal women, 230 pre/perimenopausal women and 2165 men (median age 63.3 years). There was a significant interaction between age and sex (P=.024) for TBV, where the inverse association age with TBV was steeper in women (beta=-5.35 mL/year) than in men (beta=-4.77 mL/year). Similar age-sex interactions were also observed for GMV and WMV. In women, there was a significant interaction between age and menopausal status (P=.007) where the inverse association of age with TBV was steeper in postmenopausal (beta=-5.89 mL/year) than in pre/perimenopausal women (beta=-1.61 mL/year). Similar age-menopause interactions were found in predicting lower GMV and higher WMHV. Differences in the direction of these age-sex and age-menopause interactions were found for regional cortical and subcortical brain volumes. Conclusion(s): Sex and menopause both interact with age during midlife in explaining MRI biomarkers of dementia. Further work is required to understand the mechanisms driving these interactions to develop strategies for delaying dementia.Copyright © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Published: 2021

17. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Author: Best J.G., Ambler G., Wilson D., Lee K.-J., Lim J.-S., Shiozawa M., Koga M., Li L., Lovelock C., Chabriat H., Hennerici M., Wong Y.K., Mak H.K.F., Prats-Sanchez L., Martinez-Domeno A., Inamura S., Yoshifuji K., Arsava E.M., Horstmann S., Purrucker J., Lam B.Y.K., Wong A., Kim Y.D., Song T.-J., Lemmens R., Eppinger S., Gattringer T., Uysal E., Tanriverdi Z., Bornstein N.M., Ben Assayag E., Hallevi H., Molad J., Nishihara M., Tanaka J., Coutts S.B., Polymeris A., Wagner B., Seiffge D.J., Lyrer P., Algra A., Kappelle L.J., Al-Shahi Salman R., Jager H.R., Lip G.Y.H., Fischer U., El-Koussy M., Mas J.-L., Legrand L., Karayiannis C., Phan T., Gunkel S., Christ N., Abrigo J., Leung T., Chu W., Chappell F., Makin S., Hayden D., Williams D.J., Mess W.H., Nederkoorn P.J., Barbato C., Browning S., Wiegertjes K., Tuladhar A.M., Maaijwee N., Guevarra A.C., Yatawara C., Mendyk A.-M., Delmaire C., Kohler S., van Oostenbrugge R., Zhou Y., Xu C., Hilal S., Gyanwali B., Chen C., Lou M., Staals J., Bordet R., Kandiah N., de Leeuw F.-E., Simister R., Hendrikse J., Kelly P.J., Wardlaw J., Soo Y., Fluri F., Srikanth V., Calvet D., Jung S., Kwa V.I.H., Engelter S.T., Peters N., Smith E.E., Hara H., Yakushiji Y., Orken D.N., Fazekas F., Thijs V., Heo J.H., Mok V., Veltkamp R., Ay H., Imaizumi T., Gomez-Anson B., Lau K.K., Jouvent E., Rothwell P.M., Toyoda K., Bae H.-J., Marti-Fabregas J., Werring D.J., Harkness K., Shaw L., Sword J., Mohd Nor A., Sharma P., Kelly D., Harrington F., Randall M., Smith M., Mahawish K., Elmarim A., Esisi B., Cullen C., Nallasivam A., Price C., Barry A., Roffe C., Coyle J., Hassan A., Birns J., Cohen D., Sekaran L., Parry-Jones A., Parry A., Hargroves D., Proschel H., Datta P., Darawil K., Manoj A., Burn M., Patterson C., Giallombardo E., Smyth N., Mansoor S., Anwar I., Marsh R., Ispoglou S., Chadha D., Prabhakaran M., Meenakishundaram S., O'Connell J., Scott J., Krishnamurthy V., Aghoram P., McCormick M., Sprigg N., O'Mahony P., Cooper M., Choy L., Wilkinson P., Leach S., Caine S., Burger I., Gunathilagan G., Guyler P., Emsley H., Davis M., Manawadu D., Pasco K., Mamun M., Luder R., Sajid M., Okwera J., Warburton E., Saastamoinen K., England T., Putterill J., Flossman E., Power M., Dani K., Mangion D., Suman A., Corrigan J., Lawrence E., Vahidassr D., Shakeshaft C., Brown M., Charidimou A., Cohen H., Banerjee G., Houlden H., White M., Yousry T., Flossmann E., Muir K., Gratz P., Mattle H., Panos L., Korczyn A., Kliper E., Maeder P., Gass A., Pachai C., Bracoub L., Douste-Blazy M.-Y., Fratacci M.D., Vicaut E., Sato S., Miwa K., Fujita K., Ide T., Ma H., Ly J., Singhal S., Chandra R., Slater L.-A., Soufan C., Moran C., Traenka C., Thilemann S., Fladt J., Gensicke H., Bonati L., Kim B.J., Han M.-K., Kang J., Ko E., Yang M.H., Jang M.S., Murphy S., Carty F., Akijian L., Thornton J., Schembri M., Douven E., Delgado-Mederos R., Marin R., Camps-Renom P., Guisado-Alonso D., Nunez F., Medrano-Martorell S., Merino E., Iida K., Ikeda S., Irie H., Demirelli D.S., Medanta J.M., Zerna C., Hernandez M.V., Armitage P., Heye A., Munoz-Maniega S., Sakka E., Thrippleton M., Dennis M., Beigneux Y., Silva M., Venketasubramanian N., Ho S.L., Cheung R.T.F., Chan K.H., Teo K.C., Hui E., Kwan J.S.K., Chang R., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Leung K.T., Tsang S.F., Ip H.L., Ma S.H., Ma K., Fong W.C., Li S.H., Li R., Ng P.W., Wong K.K., Liu W., Wong L., Ramos L., De Schryver E., Jobsis J., van der Sande J., Brouwers P., Roos Y., Stam J., Bakker S., Verbiest H., Schoonewille W., Linn C., Hertzberger L., van Gemert M., Berntsen P., Van Dam-Nolen D., Kooi M.E., Van der Lugt A., Koudstaal P., Leff A., Ward N., Nachev P., Perry R., Ozkan H., Mitchell J., Best J.G., Ambler G., Wilson D., Lee K.-J., Lim J.-S., Shiozawa M., Koga M., Li L., Lovelock C., Chabriat H., Hennerici M., Wong Y.K., Mak H.K.F., Prats-Sanchez L., Martinez-Domeno A., Inamura S., Yoshifuji K., Arsava E.M., Horstmann S., Purrucker J., Lam B.Y.K., Wong A., Kim Y.D., Song T.-J., Lemmens R., Eppinger S., Gattringer T., Uysal E., Tanriverdi Z., Bornstein N.M., Ben Assayag E., Hallevi H., Molad J., Nishihara M., Tanaka J., Coutts S.B., Polymeris A., Wagner B., Seiffge D.J., Lyrer P., Algra A., Kappelle L.J., Al-Shahi Salman R., Jager H.R., Lip G.Y.H., Fischer U., El-Koussy M., Mas J.-L., Legrand L., Karayiannis C., Phan T., Gunkel S., Christ N., Abrigo J., Leung T., Chu W., Chappell F., Makin S., Hayden D., Williams D.J., Mess W.H., Nederkoorn P.J., Barbato C., Browning S., Wiegertjes K., Tuladhar A.M., Maaijwee N., Guevarra A.C., Yatawara C., Mendyk A.-M., Delmaire C., Kohler S., van Oostenbrugge R., Zhou Y., Xu C., Hilal S., Gyanwali B., Chen C., Lou M., Staals J., Bordet R., Kandiah N., de Leeuw F.-E., Simister R., Hendrikse J., Kelly P.J., Wardlaw J., Soo Y., Fluri F., Srikanth V., Calvet D., Jung S., Kwa V.I.H., Engelter S.T., Peters N., Smith E.E., Hara H., Yakushiji Y., Orken D.N., Fazekas F., Thijs V., Heo J.H., Mok V., Veltkamp R., Ay H., Imaizumi T., Gomez-Anson B., Lau K.K., Jouvent E., Rothwell P.M., Toyoda K., Bae H.-J., Marti-Fabregas J., Werring D.J., Harkness K., Shaw L., Sword J., Mohd Nor A., Sharma P., Kelly D., Harrington F., Randall M., Smith M., Mahawish K., Elmarim A., Esisi B., Cullen C., Nallasivam A., Price C., Barry A., Roffe C., Coyle J., Hassan A., Birns J., Cohen D., Sekaran L., Parry-Jones A., Parry A., Hargroves D., Proschel H., Datta P., Darawil K., Manoj A., Burn M., Patterson C., Giallombardo E., Smyth N., Mansoor S., Anwar I., Marsh R., Ispoglou S., Chadha D., Prabhakaran M., Meenakishundaram S., O'Connell J., Scott J., Krishnamurthy V., Aghoram P., McCormick M., Sprigg N., O'Mahony P., Cooper M., Choy L., Wilkinson P., Leach S., Caine S., Burger I., Gunathilagan G., Guyler P., Emsley H., Davis M., Manawadu D., Pasco K., Mamun M., Luder R., Sajid M., Okwera J., Warburton E., Saastamoinen K., England T., Putterill J., Flossman E., Power M., Dani K., Mangion D., Suman A., Corrigan J., Lawrence E., Vahidassr D., Shakeshaft C., Brown M., Charidimou A., Cohen H., Banerjee G., Houlden H., White M., Yousry T., Flossmann E., Muir K., Gratz P., Mattle H., Panos L., Korczyn A., Kliper E., Maeder P., Gass A., Pachai C., Bracoub L., Douste-Blazy M.-Y., Fratacci M.D., Vicaut E., Sato S., Miwa K., Fujita K., Ide T., Ma H., Ly J., Singhal S., Chandra R., Slater L.-A., Soufan C., Moran C., Traenka C., Thilemann S., Fladt J., Gensicke H., Bonati L., Kim B.J., Han M.-K., Kang J., Ko E., Yang M.H., Jang M.S., Murphy S., Carty F., Akijian L., Thornton J., Schembri M., Douven E., Delgado-Mederos R., Marin R., Camps-Renom P., Guisado-Alonso D., Nunez F., Medrano-Martorell S., Merino E., Iida K., Ikeda S., Irie H., Demirelli D.S., Medanta J.M., Zerna C., Hernandez M.V., Armitage P., Heye A., Munoz-Maniega S., Sakka E., Thrippleton M., Dennis M., Beigneux Y., Silva M., Venketasubramanian N., Ho S.L., Cheung R.T.F., Chan K.H., Teo K.C., Hui E., Kwan J.S.K., Chang R., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Leung K.T., Tsang S.F., Ip H.L., Ma S.H., Ma K., Fong W.C., Li S.H., Li R., Ng P.W., Wong K.K., Liu W., Wong L., Ramos L., De Schryver E., Jobsis J., van der Sande J., Brouwers P., Roos Y., Stam J., Bakker S., Verbiest H., Schoonewille W., Linn C., Hertzberger L., van Gemert M., Berntsen P., Van Dam-Nolen D., Kooi M.E., Van der Lugt A., Koudstaal P., Leff A., Ward N., Nachev P., Perry R., Ozkan H., and Mitchell J.
Abstract: Background: Balancing the risks of recurrent ischaemic stroke and intracranial haemorrhage is important for patients treated with antithrombotic therapy after ischaemic stroke or transient ischaemic attack. However, existing predictive models offer insufficient performance, particularly for assessing the risk of intracranial haemorrhage. We aimed to develop new risk scores incorporating clinical variables and cerebral microbleeds, an MRI biomarker of intracranial haemorrhage and ischaemic stroke risk. Method(s): We did a pooled analysis of individual-patient data from the Microbleeds International Collaborative Network (MICON), which includes 38 hospital-based prospective cohort studies from 18 countries. All studies recruited participants with previous ischaemic stroke or transient ischaemic attack, acquired baseline MRI allowing quantification of cerebral microbleeds, and followed-up participants for ischaemic stroke and intracranial haemorrhage. Participants not taking antithrombotic drugs were excluded. We developed Cox regression models to predict the 5-year risks of intracranial haemorrhage and ischaemic stroke, selecting candidate predictors on biological relevance and simplifying models using backward elimination. We derived integer risk scores for clinical use. We assessed model performance in internal validation, adjusted for optimism using bootstrapping. The study is registered on PROSPERO, CRD42016036602. Finding(s): The included studies recruited participants between Aug 28, 2001, and Feb 4, 2018. 15 766 participants had follow-up for intracranial haemorrhage, and 15 784 for ischaemic stroke. Over a median follow-up of 2 years, 184 intracranial haemorrhages and 1048 ischaemic strokes were reported. The risk models we developed included cerebral microbleed burden and simple clinical variables. Optimism-adjusted c indices were 0.73 (95% CI 0.69-0.77) with a calibration slope of 0.94 (0.81-1.06) for the intracranial haemorrhage model and 0.63 (0.62-0.65) w
Published: 2021

18. Interactions between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study.

Author: Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., Callisaya M.L., Thomson R., Phan T.G., Fornito A., Srikanth V.K., Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., Callisaya M.L., Thomson R., Phan T.G., Fornito A., and Srikanth V.K.
Abstract: Objectives: Age and female sex are risk factors for dementia, and menopause is associated with cognitive dysfunction. Previous work largely considered the effects of sex and menopause as being independent of age. We studied whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife. Method(s): In this cross-sectional study of UK Biobank participants with brain magnetic resonance imaging (MRI), we explored the interaction of age with sex or menopausal status in explaining total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), white matter hyperintensity volume (WMHV), regional cortical volume, and subcortical volume. Result(s): Data were available for 1827 postmenopausal women, 230 pre/perimenopausal women and 2165 men (median age 63.3 years). There was a significant interaction between age and sex (P=.024) for TBV, where the inverse association age with TBV was steeper in women (beta=-5.35 mL/year) than in men (beta=-4.77 mL/year). Similar age-sex interactions were also observed for GMV and WMV. In women, there was a significant interaction between age and menopausal status (P=.007) where the inverse association of age with TBV was steeper in postmenopausal (beta=-5.89 mL/year) than in pre/perimenopausal women (beta=-1.61 mL/year). Similar age-menopause interactions were found in predicting lower GMV and higher WMHV. Differences in the direction of these age-sex and age-menopause interactions were found for regional cortical and subcortical brain volumes. Conclusion(s): Sex and menopause both interact with age during midlife in explaining MRI biomarkers of dementia. Further work is required to understand the mechanisms driving these interactions to develop strategies for delaying dementia.Copyright © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Published: 2021

19. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Author: Best J.G., Ambler G., Wilson D., Lee K.-J., Lim J.-S., Shiozawa M., Koga M., Li L., Lovelock C., Chabriat H., Hennerici M., Wong Y.K., Mak H.K.F., Prats-Sanchez L., Martinez-Domeno A., Inamura S., Yoshifuji K., Arsava E.M., Horstmann S., Purrucker J., Lam B.Y.K., Wong A., Kim Y.D., Song T.-J., Lemmens R., Eppinger S., Gattringer T., Uysal E., Tanriverdi Z., Bornstein N.M., Ben Assayag E., Hallevi H., Molad J., Nishihara M., Tanaka J., Coutts S.B., Polymeris A., Wagner B., Seiffge D.J., Lyrer P., Algra A., Kappelle L.J., Al-Shahi Salman R., Jager H.R., Lip G.Y.H., Fischer U., El-Koussy M., Mas J.-L., Legrand L., Karayiannis C., Phan T., Gunkel S., Christ N., Abrigo J., Leung T., Chu W., Chappell F., Makin S., Hayden D., Williams D.J., Mess W.H., Nederkoorn P.J., Barbato C., Browning S., Wiegertjes K., Tuladhar A.M., Maaijwee N., Guevarra A.C., Yatawara C., Mendyk A.-M., Delmaire C., Kohler S., van Oostenbrugge R., Zhou Y., Xu C., Hilal S., Gyanwali B., Chen C., Lou M., Staals J., Bordet R., Kandiah N., de Leeuw F.-E., Simister R., Hendrikse J., Kelly P.J., Wardlaw J., Soo Y., Fluri F., Srikanth V., Calvet D., Jung S., Kwa V.I.H., Engelter S.T., Peters N., Smith E.E., Hara H., Yakushiji Y., Orken D.N., Fazekas F., Thijs V., Heo J.H., Mok V., Veltkamp R., Ay H., Imaizumi T., Gomez-Anson B., Lau K.K., Jouvent E., Rothwell P.M., Toyoda K., Bae H.-J., Marti-Fabregas J., Werring D.J., Harkness K., Shaw L., Sword J., Mohd Nor A., Sharma P., Kelly D., Harrington F., Randall M., Smith M., Mahawish K., Elmarim A., Esisi B., Cullen C., Nallasivam A., Price C., Barry A., Roffe C., Coyle J., Hassan A., Birns J., Cohen D., Sekaran L., Parry-Jones A., Parry A., Hargroves D., Proschel H., Datta P., Darawil K., Manoj A., Burn M., Patterson C., Giallombardo E., Smyth N., Mansoor S., Anwar I., Marsh R., Ispoglou S., Chadha D., Prabhakaran M., Meenakishundaram S., O'Connell J., Scott J., Krishnamurthy V., Aghoram P., McCormick M., Sprigg N., O'Mahony P., Cooper M., Choy L., Wilkinson P., Leach S., Caine S., Burger I., Gunathilagan G., Guyler P., Emsley H., Davis M., Manawadu D., Pasco K., Mamun M., Luder R., Sajid M., Okwera J., Warburton E., Saastamoinen K., England T., Putterill J., Flossman E., Power M., Dani K., Mangion D., Suman A., Corrigan J., Lawrence E., Vahidassr D., Shakeshaft C., Brown M., Charidimou A., Cohen H., Banerjee G., Houlden H., White M., Yousry T., Flossmann E., Muir K., Gratz P., Mattle H., Panos L., Korczyn A., Kliper E., Maeder P., Gass A., Pachai C., Bracoub L., Douste-Blazy M.-Y., Fratacci M.D., Vicaut E., Sato S., Miwa K., Fujita K., Ide T., Ma H., Ly J., Singhal S., Chandra R., Slater L.-A., Soufan C., Moran C., Traenka C., Thilemann S., Fladt J., Gensicke H., Bonati L., Kim B.J., Han M.-K., Kang J., Ko E., Yang M.H., Jang M.S., Murphy S., Carty F., Akijian L., Thornton J., Schembri M., Douven E., Delgado-Mederos R., Marin R., Camps-Renom P., Guisado-Alonso D., Nunez F., Medrano-Martorell S., Merino E., Iida K., Ikeda S., Irie H., Demirelli D.S., Medanta J.M., Zerna C., Hernandez M.V., Armitage P., Heye A., Munoz-Maniega S., Sakka E., Thrippleton M., Dennis M., Beigneux Y., Silva M., Venketasubramanian N., Ho S.L., Cheung R.T.F., Chan K.H., Teo K.C., Hui E., Kwan J.S.K., Chang R., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Leung K.T., Tsang S.F., Ip H.L., Ma S.H., Ma K., Fong W.C., Li S.H., Li R., Ng P.W., Wong K.K., Liu W., Wong L., Ramos L., De Schryver E., Jobsis J., van der Sande J., Brouwers P., Roos Y., Stam J., Bakker S., Verbiest H., Schoonewille W., Linn C., Hertzberger L., van Gemert M., Berntsen P., Van Dam-Nolen D., Kooi M.E., Van der Lugt A., Koudstaal P., Leff A., Ward N., Nachev P., Perry R., Ozkan H., Mitchell J., Best J.G., Ambler G., Wilson D., Lee K.-J., Lim J.-S., Shiozawa M., Koga M., Li L., Lovelock C., Chabriat H., Hennerici M., Wong Y.K., Mak H.K.F., Prats-Sanchez L., Martinez-Domeno A., Inamura S., Yoshifuji K., Arsava E.M., Horstmann S., Purrucker J., Lam B.Y.K., Wong A., Kim Y.D., Song T.-J., Lemmens R., Eppinger S., Gattringer T., Uysal E., Tanriverdi Z., Bornstein N.M., Ben Assayag E., Hallevi H., Molad J., Nishihara M., Tanaka J., Coutts S.B., Polymeris A., Wagner B., Seiffge D.J., Lyrer P., Algra A., Kappelle L.J., Al-Shahi Salman R., Jager H.R., Lip G.Y.H., Fischer U., El-Koussy M., Mas J.-L., Legrand L., Karayiannis C., Phan T., Gunkel S., Christ N., Abrigo J., Leung T., Chu W., Chappell F., Makin S., Hayden D., Williams D.J., Mess W.H., Nederkoorn P.J., Barbato C., Browning S., Wiegertjes K., Tuladhar A.M., Maaijwee N., Guevarra A.C., Yatawara C., Mendyk A.-M., Delmaire C., Kohler S., van Oostenbrugge R., Zhou Y., Xu C., Hilal S., Gyanwali B., Chen C., Lou M., Staals J., Bordet R., Kandiah N., de Leeuw F.-E., Simister R., Hendrikse J., Kelly P.J., Wardlaw J., Soo Y., Fluri F., Srikanth V., Calvet D., Jung S., Kwa V.I.H., Engelter S.T., Peters N., Smith E.E., Hara H., Yakushiji Y., Orken D.N., Fazekas F., Thijs V., Heo J.H., Mok V., Veltkamp R., Ay H., Imaizumi T., Gomez-Anson B., Lau K.K., Jouvent E., Rothwell P.M., Toyoda K., Bae H.-J., Marti-Fabregas J., Werring D.J., Harkness K., Shaw L., Sword J., Mohd Nor A., Sharma P., Kelly D., Harrington F., Randall M., Smith M., Mahawish K., Elmarim A., Esisi B., Cullen C., Nallasivam A., Price C., Barry A., Roffe C., Coyle J., Hassan A., Birns J., Cohen D., Sekaran L., Parry-Jones A., Parry A., Hargroves D., Proschel H., Datta P., Darawil K., Manoj A., Burn M., Patterson C., Giallombardo E., Smyth N., Mansoor S., Anwar I., Marsh R., Ispoglou S., Chadha D., Prabhakaran M., Meenakishundaram S., O'Connell J., Scott J., Krishnamurthy V., Aghoram P., McCormick M., Sprigg N., O'Mahony P., Cooper M., Choy L., Wilkinson P., Leach S., Caine S., Burger I., Gunathilagan G., Guyler P., Emsley H., Davis M., Manawadu D., Pasco K., Mamun M., Luder R., Sajid M., Okwera J., Warburton E., Saastamoinen K., England T., Putterill J., Flossman E., Power M., Dani K., Mangion D., Suman A., Corrigan J., Lawrence E., Vahidassr D., Shakeshaft C., Brown M., Charidimou A., Cohen H., Banerjee G., Houlden H., White M., Yousry T., Flossmann E., Muir K., Gratz P., Mattle H., Panos L., Korczyn A., Kliper E., Maeder P., Gass A., Pachai C., Bracoub L., Douste-Blazy M.-Y., Fratacci M.D., Vicaut E., Sato S., Miwa K., Fujita K., Ide T., Ma H., Ly J., Singhal S., Chandra R., Slater L.-A., Soufan C., Moran C., Traenka C., Thilemann S., Fladt J., Gensicke H., Bonati L., Kim B.J., Han M.-K., Kang J., Ko E., Yang M.H., Jang M.S., Murphy S., Carty F., Akijian L., Thornton J., Schembri M., Douven E., Delgado-Mederos R., Marin R., Camps-Renom P., Guisado-Alonso D., Nunez F., Medrano-Martorell S., Merino E., Iida K., Ikeda S., Irie H., Demirelli D.S., Medanta J.M., Zerna C., Hernandez M.V., Armitage P., Heye A., Munoz-Maniega S., Sakka E., Thrippleton M., Dennis M., Beigneux Y., Silva M., Venketasubramanian N., Ho S.L., Cheung R.T.F., Chan K.H., Teo K.C., Hui E., Kwan J.S.K., Chang R., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Leung K.T., Tsang S.F., Ip H.L., Ma S.H., Ma K., Fong W.C., Li S.H., Li R., Ng P.W., Wong K.K., Liu W., Wong L., Ramos L., De Schryver E., Jobsis J., van der Sande J., Brouwers P., Roos Y., Stam J., Bakker S., Verbiest H., Schoonewille W., Linn C., Hertzberger L., van Gemert M., Berntsen P., Van Dam-Nolen D., Kooi M.E., Van der Lugt A., Koudstaal P., Leff A., Ward N., Nachev P., Perry R., Ozkan H., and Mitchell J.
Abstract: Background: Balancing the risks of recurrent ischaemic stroke and intracranial haemorrhage is important for patients treated with antithrombotic therapy after ischaemic stroke or transient ischaemic attack. However, existing predictive models offer insufficient performance, particularly for assessing the risk of intracranial haemorrhage. We aimed to develop new risk scores incorporating clinical variables and cerebral microbleeds, an MRI biomarker of intracranial haemorrhage and ischaemic stroke risk. Method(s): We did a pooled analysis of individual-patient data from the Microbleeds International Collaborative Network (MICON), which includes 38 hospital-based prospective cohort studies from 18 countries. All studies recruited participants with previous ischaemic stroke or transient ischaemic attack, acquired baseline MRI allowing quantification of cerebral microbleeds, and followed-up participants for ischaemic stroke and intracranial haemorrhage. Participants not taking antithrombotic drugs were excluded. We developed Cox regression models to predict the 5-year risks of intracranial haemorrhage and ischaemic stroke, selecting candidate predictors on biological relevance and simplifying models using backward elimination. We derived integer risk scores for clinical use. We assessed model performance in internal validation, adjusted for optimism using bootstrapping. The study is registered on PROSPERO, CRD42016036602. Finding(s): The included studies recruited participants between Aug 28, 2001, and Feb 4, 2018. 15 766 participants had follow-up for intracranial haemorrhage, and 15 784 for ischaemic stroke. Over a median follow-up of 2 years, 184 intracranial haemorrhages and 1048 ischaemic strokes were reported. The risk models we developed included cerebral microbleed burden and simple clinical variables. Optimism-adjusted c indices were 0.73 (95% CI 0.69-0.77) with a calibration slope of 0.94 (0.81-1.06) for the intracranial haemorrhage model and 0.63 (0.62-0.65) w
Published: 2021

20. Participant followup rate can bias structural imaging measures in longitudinal studies

Author: Beare, R, Ball, G, Yang, JYM, Moran, C, Srikanth, V, Seal, M, Beare, R, Ball, G, Yang, JYM, Moran, C, Srikanth, V, and Seal, M
Published: 2021

21. Validation of the 'knowledge about melanoma early detection scale' in a sample of melanoma survivors

Author: Coroiu, A., Moran, C., Kwakkenbos, L., Thombs, B.D., Körner, A., Coroiu, A., Moran, C., Kwakkenbos, L., Thombs, B.D., and Körner, A.
Abstract: 29 januari 2021, Item does not contain fulltext, The purpose of this study was to describe the development and preliminary testing of a new scale assessing knowledge about melanoma risk factors and early detection/secondary prevention. Data was drawn from a longitudinal study assessing barriers and facilitators of skin self- examination among patients diagnosed with melanoma. For the current analysis, 191 patients who completed the new 9-item Knowledge About Melanoma Early Detection Scale and other study measures were included. Exploratory factor analysis with were conducted, which identified a robust scale comprised of 6 items with factor loadings ranging from .56 to .81. Higher scores on the Knowledge About Melanoma Early Detection Scale were associated with younger age and more positive attitudes about melanoma prevention, but not with biological sex, education, melanoma stage, or past self-administered and physician-provided skin checks. Further studies are needed to replicate these findings and to further establish the predictive validity of this scale and its usefulness for health research.
Published: 2021

22. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Author: Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., Claesson, M. J., Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.
Abstract: Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic mucosa [50 Crohn’s disease (CD); 80 ulcerative colitis (UC); 31 controls]. Changes in community-wide and within-patient microbiota are linked with inflammation, but we find no evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe interactions, and show only marginal microbiota associations with habitual diet. Epithelial DNA methylation improves disease classification and is associated with both inflammation and microbiota composition. Microbiota sub-groups are driven by dominant Enterbacteriaceae and Bacteroides species, representative strains of which are pro-inflammatory in vitro, are also associated with immune-related epigenetic markers. In conclusion, inflamed and non-inflamed colonic segments in both CD and UC differ in microbiota composition and epigenetic profiles.
Published: 2020

23. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study

Author: Groeneweg, S., Geest, F.S. van, Abaci, A., Alcantud, A., Ambegaonkar, G.P., Armour, C.M., Bakhtiani, P., Barca, D., Bertini, E.S., Beijnum, I.M. van, Brunetti-Pierri, N., Bugiani, M., Cappa, M., Cappuccio, G., Castellotti, B., Castiglioni, C., Chatterjee, K., Coo, I.F.M. de, Coutant, R., Craiu, D., Crock, P., DeGoede, C., Demir, K., Dica, A., Dimitri, P., Dolcetta-Capuzzo, A., Dremmen, M.H.G., Dubey, R., Enderli, A., Fairchild, J., Gallichan, J., George, B., Gevers, E.F., Hackenberg, A., Halasz, Z., Heinrich, B., Huynh, T., Klosowska, A., Knaap, M.S. van der, Knoop, M.M. van der, Konrad, D., Koolen, D.A., Krude, H., Lawson-Yuen, A., Lebl, J., Linder-Lucht, M., Lorea, C.F., Lourenco, C.M., Lunsing, R.J., Lyons, G., Malikova, J., Mancilla, E.E., McGowan, A., Mericq, V., Lora, F.M., Moran, C., Muller, K.E., Oliver-Petit, I., Paone, L., Paul, P.G., Polak, M, Porta, F., Poswar, F.O., Reinauer, C., Rozenkova, K., Menevse, T.S., Simm, P., Simon, A., Singh, Y., Spada, M., Spek, J. van der, Stals, M.A.M., Stoupa, A., Subramanian, G.M., Tonduti, D., Turan, S., Uil, C.A. den, Vanderniet, J., Walt, A. van der, Wemeau, J.L., Wierzba, J., Wit, M.Y. de, Wolf, N.I., Wurm, M., Zibordi, F., Zung, A., Zwaveling-Soonawala, N., Visser, Wesley J., Groeneweg, S., Geest, F.S. van, Abaci, A., Alcantud, A., Ambegaonkar, G.P., Armour, C.M., Bakhtiani, P., Barca, D., Bertini, E.S., Beijnum, I.M. van, Brunetti-Pierri, N., Bugiani, M., Cappa, M., Cappuccio, G., Castellotti, B., Castiglioni, C., Chatterjee, K., Coo, I.F.M. de, Coutant, R., Craiu, D., Crock, P., DeGoede, C., Demir, K., Dica, A., Dimitri, P., Dolcetta-Capuzzo, A., Dremmen, M.H.G., Dubey, R., Enderli, A., Fairchild, J., Gallichan, J., George, B., Gevers, E.F., Hackenberg, A., Halasz, Z., Heinrich, B., Huynh, T., Klosowska, A., Knaap, M.S. van der, Knoop, M.M. van der, Konrad, D., Koolen, D.A., Krude, H., Lawson-Yuen, A., Lebl, J., Linder-Lucht, M., Lorea, C.F., Lourenco, C.M., Lunsing, R.J., Lyons, G., Malikova, J., Mancilla, E.E., McGowan, A., Mericq, V., Lora, F.M., Moran, C., Muller, K.E., Oliver-Petit, I., Paone, L., Paul, P.G., Polak, M, Porta, F., Poswar, F.O., Reinauer, C., Rozenkova, K., Menevse, T.S., Simm, P., Simon, A., Singh, Y., Spada, M., Spek, J. van der, Stals, M.A.M., Stoupa, A., Subramanian, G.M., Tonduti, D., Turan, S., Uil, C.A. den, Vanderniet, J., Walt, A. van der, Wemeau, J.L., Wierzba, J., Wit, M.Y. de, Wolf, N.I., Wurm, M., Zibordi, F., Zung, A., Zwaveling-Soonawala, N., and Visser, Wesley J.
Abstract: Contains fulltext : 220431.pdf (Publisher’s version ) (Closed access), BACKGROUND: Disordered thyroid hormone transport, due to mutations in the SLC16A2 gene encoding monocarboxylate transporter 8 (MCT8), is characterised by intellectual and motor disability resulting from cerebral hypothyroidism and chronic peripheral thyrotoxicosis. We sought to systematically assess the phenotypic characteristics and natural history of patients with MCT8 deficiency. METHODS: We did an international, multicentre, cohort study, analysing retrospective data from Jan 1, 2003, to Dec 31, 2019, from patients with MCT8 deficiency followed up in 47 hospitals in 22 countries globally. The key inclusion criterion was genetically confirmed MCT8 deficiency. There were no exclusion criteria. Our primary objective was to analyse the overall survival of patients with MCT8 deficiency and document causes of death. We also compared survival between patients who did or did not attain full head control by age 1.5 years and between patients who were or were not underweight by age 1-3 years (defined as a bodyweight-for-age Z score <-2 SDs or <5th percentile according to WHO definition). Other objectives were to assess neurocognitive function and outcomes, and clinical parameters including anthropometric characteristics, biochemical markers, and neuroimaging findings. FINDINGS: Between Oct 14, 2014, and Jan 17, 2020, we enrolled 151 patients with 73 different MCT8 (SLC16A2) mutations. Median age at diagnosis was 24.0 months (IQR 12.0-60.0, range 0.0-744.0). 32 (21%) of 151 patients died; the main causes of mortality in these patients were pulmonary infection (six [19%]) and sudden death (six [19%]). Median overall survival was 35.0 years (95% CI 8.3-61.7). Individuals who did not attain head control by age 1.5 years had an increased risk of death compared with patients who did attain head control (hazard ratio [HR] 3.46, 95% CI 1.76-8.34; log-rank test p=0.0041). Patients who were underweight during age 1-3 years had an increased risk for death compared with patients who
Published: 2020

24. Psychosocial volunteer support for older adults with cognitive impairment: Development of MyCare Ageing using a codesign approach via action research.

Author: Lustig J., Hunter P., Pritchard E., Morris H., Savaglio M., Parikh S., Skouteris H., Ayton D., O'Donnell R., Vicary D., Bateman C., Moran C., Srikanth V.K., Banaszak-Holl J., Lustig J., Hunter P., Pritchard E., Morris H., Savaglio M., Parikh S., Skouteris H., Ayton D., O'Donnell R., Vicary D., Bateman C., Moran C., Srikanth V.K., and Banaszak-Holl J.
Abstract: Background and objectives Older adults with cognitive impairment are vulnerable to frequent hospital admissions and emergency department presentations. The aim of this study was to use a codesign approach to develop MyCare Ageing, a programme that will train volunteers to provide psychosocial support to older people with dementia and/or delirium in hospital and at home when discharged from hospital. Setting Melbourne, Victoria, Australia. Research design This study adopts an action research methodology. We report on two co-design workshops with keystakeholders: Workshop 1: identification of components from three existing programmes to inform the development of the MyCare Ageing program logic and, Workshop 2: identification of implementation strategies. Participants The key stakeholders and workshop participants included clinicians (geriatricians, nurses and allied health), hospital staff (volunteer coordinators and hospital executives), Baptcare staff, a consumer, researchers and implementation experts and project staff. Results Workshop 1 identified the components from three existing programmes - the Volunteer Dementia and Delirium Care programme, Home-Start and MyCare for inclusion in MyCare Ageing. In workshop 2, the p implementation plan was developed taking into consideration hospital-specific processes, training and support needs of volunteers and safety and risk management processes. Discussion and conclusion The codesign process was successfully applied to develop the MyCare Ageing programme to provide volunteer support to patients with dementia and/or delirium in hospital and their transition home. MyCare Ageing is an innovative programme that meets an identified need from hospitals and consumers to support patients with dementia and/or delirium to improve psychosocial outcomes on discharge from hospital.Copyright © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Published: 2020

25. Initial experiences of an in-reach service providing iron infusions in residential aged care facilities.

Author: Poojary S., Zinsaz H., Gibson P.R., Moran C., Calder G., Corallo C., Poojary S., Zinsaz H., Gibson P.R., Moran C., Calder G., and Corallo C.
Abstract: OBJECTIVE: To examine the feasibility of developing an in-reach parenteral iron infusion service to residents of residential aged care facilities (RACFs). METHOD(S): An audit comparing the use of iron infusions in RACFs prior to and following the introduction of an in-reach iron infusion service. RESULT(S): Of the 738 inpatient iron infusions administered to inpatients >=65 years in the 12 months prior to the in-reach service, 52 (7%) lived in an RACF, with no significant adverse events reported. After implementation of an in-reach service, a total of 37 RACF residents received parenteral iron in the first 12 months of the service, with no significant adverse events reported. CONCLUSION(S): It is possible to safely provide parenteral iron through an in-reach service to residents in RACF. Further research is required to identify the person-level benefits achieved by this service.Copyright © 2020 AJA Inc.
Published: 2020

26. Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study.

Author: Phan T.G., Thomson R., Fornito A., Srikanth V.K., Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., Callisaya M.L., Phan T.G., Thomson R., Fornito A., Srikanth V.K., Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., and Callisaya M.L.
Abstract: OBJECTIVES: Age and female sex are risk factors for dementia, and menopause is associated with cognitive dysfunction. Previous work largely considered the effects of sex and menopause as being independent of age. We studied whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife. METHOD(S): In this cross-sectional study of UK Biobank participants with brain magnetic resonance imaging (MRI), we explored the interaction of age with sex or menopausal status in explaining total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), white matter hyperintensity volume (WMHV), regional cortical volume , and subcortical volume. RESULT(S): Data were available for 1827 postmenopausal women, 230 pre/perimenopausal women and 2165 men (median age 63.3 years). There was a significant interaction between age and sex (P = .024) for TBV, where the inverse association age with TBV was steeper in women (beta = -5.35 mL/year) than in men (beta = -4.77 mL/year). Similar age-sex interactions were also observed for GMV and WMV. In women, there was a significant interaction between age and menopausal status (P = .007) where the inverse association of age with TBV was steeper in postmenopausal (beta = -5.89 mL/year) than in pre/perimenopausal women (beta = -1.61 mL/year). Similar age-menopause interactions were found in predicting lower GMV and higher WMHV. Differences in the direction of these age-sex and age-menopause interactions were found for regional cortical and subcortical brain volumes. CONCLUSION(S): Sex and menopause both interact with age during midlife in explaining MRI biomarkers of dementia. Further work is required to understand the mechanisms driving these interactions to develop strategies for delaying dementia.Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Published: 2020

27. Familial dysalbuminaemic hyperthyroxinaemia interferes with current free thyroid hormone immunoassay methods

Author: Khoo, S, Lyons, G, McGowan, A., Gurnell, M. (Mark), Oddy, S., Visser, W.E. (Edward), van den Berg, S., Halsall, D, Taylor, K.D. (Kent), Chatterjee, K. (Krishna), Moran, C. (Carla), Khoo, S, Lyons, G, McGowan, A., Gurnell, M. (Mark), Oddy, S., Visser, W.E. (Edward), van den Berg, S., Halsall, D, Taylor, K.D. (Kent), Chatterjee, K. (Krishna), and Moran, C. (Carla)
Abstract: Objective: Familial dysalbuminaemic hyperthyroxinaemia (FDH), most commonly due to an Arginine to Histidine mutation at residue 218 (R218H) in the albumin gene, causes artefactual elevation of free thyroid hormones in euthyroid individuals. We have evaluated the susceptibility of most current free thyroid hormone immunoassay methods used in the United Kingdom, Europe and Far East to interference by R218H FDH. Methods: Different, one- and two-step immunoassay methods were tested, measuring free T4 (FT4) and free T3 (FT3) in 37 individuals with genetically proven R218H FDH. Results: With the exception of Ortho VITROS, FT4 measurements were raised in all assays, with greatest to lowest susceptibility to interference being Beckman ACCESS > Roche ELECSYS > FUJIREBIO Lumipulse > Siemens CENTAUR > Abbott ARCHITECT > Perkin-Elmer DELFIA. Five different assays recorded high FT3 levels, with the Siemens CENTAUR method measuring high FT3 values in up to 30% of cases. However, depending on the assay method, FT4 measurements were unexpectedly normal in some, g
Published: 2020
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28. Searching for Anisotropic Cosmic Birefringence with Polarization Data from SPTpol

Author: Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., and Yefremenko, V.
Abstract: We present a search for anisotropic cosmic birefringence in 500 deg$^2$ of southern sky observed at 150 GHz with the SPTpol camera on the South Pole Telescope. We reconstruct a map of cosmic polarization rotation anisotropies using higher-order correlations between the observed cosmic microwave background (CMB) $E$ and $B$ fields. We then measure the angular power spectrum of this map, which is found to be consistent with zero. The non-detection is translated into an upper limit on the amplitude of the scale-invariant cosmic rotation power spectrum, $L(L+1)C_L^{\alpha\alpha}/2\pi < 0.10 \times 10^{-4}$ rad$^2$ (0.033 deg$^2$, 95% C.L.). This upper limit can be used to place constraints on the strength of primordial magnetic fields, $B_{1 \rm Mpc} < 17 {\rm nG} $ (95% C.L.), and on the coupling constant of the Chern-Simons electromagnetic term $g_{a\gamma} < 4.0 \times 10^{-2}/H_I $ (95% C.L.), where $H_I$ is the inflationary Hubble scale. For the first time, we also cross-correlate the CMB temperature fluctuations with the reconstructed rotation angle map, a signal expected to be non-vanishing in certain theoretical scenarios, and find no detectable signal. We perform a suite of systematics and consistency checks and find no evidence for contamination., Comment: 17 pages, 7 figures - new subsection on non-Gaussian foregrounds, conclusions unchanged - updated to match published version on PRD
Published: 2020
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29. An Improved Measurement of the Secondary Cosmic Microwave Background Anisotropies from the SPT-SZ + SPTpol Surveys

Author: Reichardt, C. L., Patil, S., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Luong-Van, D., McMahon, J. J., Mehl, J., Meyer, S. S., Millea, M., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Sievers, C., Smecher, G., Spieler, H. G., Staniszewski, Z., Stark, A. A., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Williamson, R., Wu, W. L. K., Yefremenko, V., Reichardt, C. L., Patil, S., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Luong-Van, D., McMahon, J. J., Mehl, J., Meyer, S. S., Millea, M., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Sievers, C., Smecher, G., Spieler, H. G., Staniszewski, Z., Stark, A. A., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Williamson, R., Wu, W. L. K., and Yefremenko, V.
Abstract: We report new measurements of millimeter-wave power spectra in the angular multipole range $2000 \le \ell \le 11,000$ (angular scales $5^\prime \gtrsim \theta \gtrsim 1^\prime$). By adding 95 and 150\,GHz data from the low-noise 500 deg$^2$ SPTpol survey to the SPT-SZ three-frequency 2540 deg$^2$ survey, we substantially reduce the uncertainties in these bands. These power spectra include contributions from the primary cosmic microwave background, cosmic infrared background, radio galaxies, and thermal and kinematic Sunyaev-Zel'dovich (SZ) effects. The data favor a thermal SZ (tSZ) power at 143\,GHz of $D^{\rm tSZ}_{3000} = 3.42 \pm 0.54~ \mu {\rm K}^2$ and a kinematic SZ (kSZ) power of $D^{\rm kSZ}_{3000} = 3.0 \pm 1.0~ \mu {\rm K}^2$. This is the first measurement of kSZ power at $\ge 3\,\sigma$. We study the implications of the measured kSZ power for the epoch of reionization, finding the duration of reionization to be $\Delta z_{re} = 1.0^{+1.6}_{-0.7}$ ($\Delta z_{re}< 4.1$ at 95% confidence), when combined with our previously published tSZ bispectrum measurement., Comment: Submitted to ApJ, 16 pages. (revised portions of the introduction and description of bandpower estimation)
Published: 2020
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30. Psychosocial volunteer support for older adults with cognitive impairment: Development of MyCare Ageing using a codesign approach via action research.

Author: Lustig J., Hunter P., Pritchard E., Morris H., Savaglio M., Parikh S., Skouteris H., Ayton D., O'Donnell R., Vicary D., Bateman C., Moran C., Srikanth V.K., Banaszak-Holl J., Lustig J., Hunter P., Pritchard E., Morris H., Savaglio M., Parikh S., Skouteris H., Ayton D., O'Donnell R., Vicary D., Bateman C., Moran C., Srikanth V.K., and Banaszak-Holl J.
Abstract: Background and objectives Older adults with cognitive impairment are vulnerable to frequent hospital admissions and emergency department presentations. The aim of this study was to use a codesign approach to develop MyCare Ageing, a programme that will train volunteers to provide psychosocial support to older people with dementia and/or delirium in hospital and at home when discharged from hospital. Setting Melbourne, Victoria, Australia. Research design This study adopts an action research methodology. We report on two co-design workshops with keystakeholders: Workshop 1: identification of components from three existing programmes to inform the development of the MyCare Ageing program logic and, Workshop 2: identification of implementation strategies. Participants The key stakeholders and workshop participants included clinicians (geriatricians, nurses and allied health), hospital staff (volunteer coordinators and hospital executives), Baptcare staff, a consumer, researchers and implementation experts and project staff. Results Workshop 1 identified the components from three existing programmes - the Volunteer Dementia and Delirium Care programme, Home-Start and MyCare for inclusion in MyCare Ageing. In workshop 2, the p implementation plan was developed taking into consideration hospital-specific processes, training and support needs of volunteers and safety and risk management processes. Discussion and conclusion The codesign process was successfully applied to develop the MyCare Ageing programme to provide volunteer support to patients with dementia and/or delirium in hospital and their transition home. MyCare Ageing is an innovative programme that meets an identified need from hospitals and consumers to support patients with dementia and/or delirium to improve psychosocial outcomes on discharge from hospital.Copyright © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Published: 2020

31. Initial experiences of an in-reach service providing iron infusions in residential aged care facilities.

Author: Poojary S., Zinsaz H., Gibson P.R., Moran C., Calder G., Corallo C., Poojary S., Zinsaz H., Gibson P.R., Moran C., Calder G., and Corallo C.
Abstract: OBJECTIVE: To examine the feasibility of developing an in-reach parenteral iron infusion service to residents of residential aged care facilities (RACFs). METHOD(S): An audit comparing the use of iron infusions in RACFs prior to and following the introduction of an in-reach iron infusion service. RESULT(S): Of the 738 inpatient iron infusions administered to inpatients >=65 years in the 12 months prior to the in-reach service, 52 (7%) lived in an RACF, with no significant adverse events reported. After implementation of an in-reach service, a total of 37 RACF residents received parenteral iron in the first 12 months of the service, with no significant adverse events reported. CONCLUSION(S): It is possible to safely provide parenteral iron through an in-reach service to residents in RACF. Further research is required to identify the person-level benefits achieved by this service.Copyright © 2020 AJA Inc.
Published: 2020

32. Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study.

Author: Phan T.G., Thomson R., Fornito A., Srikanth V.K., Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., Callisaya M.L., Phan T.G., Thomson R., Fornito A., Srikanth V.K., Than S., Moran C., Beare R., Vincent A.J., Collyer T.A., Wang W., and Callisaya M.L.
Abstract: OBJECTIVES: Age and female sex are risk factors for dementia, and menopause is associated with cognitive dysfunction. Previous work largely considered the effects of sex and menopause as being independent of age. We studied whether age interacts with sex or menopause in explaining imaging biomarkers of dementia during midlife. METHOD(S): In this cross-sectional study of UK Biobank participants with brain magnetic resonance imaging (MRI), we explored the interaction of age with sex or menopausal status in explaining total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), white matter hyperintensity volume (WMHV), regional cortical volume , and subcortical volume. RESULT(S): Data were available for 1827 postmenopausal women, 230 pre/perimenopausal women and 2165 men (median age 63.3 years). There was a significant interaction between age and sex (P = .024) for TBV, where the inverse association age with TBV was steeper in women (beta = -5.35 mL/year) than in men (beta = -4.77 mL/year). Similar age-sex interactions were also observed for GMV and WMV. In women, there was a significant interaction between age and menopausal status (P = .007) where the inverse association of age with TBV was steeper in postmenopausal (beta = -5.89 mL/year) than in pre/perimenopausal women (beta = -1.61 mL/year). Similar age-menopause interactions were found in predicting lower GMV and higher WMHV. Differences in the direction of these age-sex and age-menopause interactions were found for regional cortical and subcortical brain volumes. CONCLUSION(S): Sex and menopause both interact with age during midlife in explaining MRI biomarkers of dementia. Further work is required to understand the mechanisms driving these interactions to develop strategies for delaying dementia.Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Published: 2020

33. White Matter Hyperintensities and the Progression of Frailty-The Tasmanian Study of Cognition and Gait

Author: Siejka, T.P., Srikanth, V.K., Hubbard, R.E., Moran, C., Beare, R., Wood, Amanda, Phan, T., Balogun, S., Callisaya, M.L., Siejka, T.P., Srikanth, V.K., Hubbard, R.E., Moran, C., Beare, R., Wood, Amanda, Phan, T., Balogun, S., and Callisaya, M.L.
Abstract: Background The contribution of cerebral small vessel disease (cSVD) to the pathogenesis of frailty remains uncertain. We aimed to examine the associations between cSVD with progression of frailty in a population-based study of older people. Methods People aged between 60 and 85 years were randomly selected form the electoral roll to participate in the Tasmanian Study of Cognition and Gait. Participants underwent self-reported questionnaires, objective gait, cognitive and sensorimotor testing over three phases ranging between 2005 and 2012. These data were used to calculate a 41-item frailty index (FI) at three time points. Baseline brain magnetic resonance imaging was performed on all participants to measure cSVD. Generalized mixed models were used to examine associations between baseline cSVD and progression of frailty, adjusted for confounders of age, sex, level of education, and total intracranial volume. Results At baseline (n = 388) mean age was 72 years (SD = 7.0), 44% were female, and the median FI score was 0.20 (interquartile range [IQR] 0.12, 0.27). In fully adjusted models higher burden of baseline white matter hyperintensity (WMH) was associated with frailty progression over 4.4 years (β = 0.03, 95% CI: 0.01, 0.05; p = .004) independent of other SVD markers. Neither baseline infarcts (p = .23), nor microbleeds at baseline (p = .65) were associated with progression of frailty. Conclusions We provide evidence for an association between baseline WMHs and progression of frailty. Our findings add to a growing body of literature suggesting WMH is a marker for frailty.
Published: 2020

34. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Author: Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., Claesson, M. J., Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.
Published: 2020

35. Survey of major trauma centre preparedness for mass casualty incidents in Australia, Canada, England and New Zealand

Author: Gabbe, BJ, Veitch, W, Curtis, K, Martin, K, Gomez, D, Civil, I, Moran, C, Teague, WJ, Holland, AJA, Lecky, F, Fitzgerald, M, Nathens, A, Joseph, A, Gabbe, BJ, Veitch, W, Curtis, K, Martin, K, Gomez, D, Civil, I, Moran, C, Teague, WJ, Holland, AJA, Lecky, F, Fitzgerald, M, Nathens, A, and Joseph, A
Abstract: BACKGROUND: Mass casualty incidents (MCIs) are increasing. Trauma centres play a key role in MCIs due to their readiness and expansive multidisciplinary expertise for injury management. Previous studies have shown deficiencies in trauma centre disaster preparedness. The aim of this study was to describe the current disaster preparedness of Major Trauma Centres (MTCs) in Australia, Canada, England and New Zealand. METHODS: A cross-sectional survey of all (n = 82) MTCs was undertaken. The anonymous survey collected data about disaster preparedness in nine key areas. Respondents were encouraged to consult appropriately at their centre to provide an accurate representation of their centre's preparedness. FINDINGS: Responses were received from 69 (84%) centres; 61 completed all questions. 91% had a disaster preparedness committee and 80% had an all-hazards emergency plan. 79% had held an MCI drill in the past 2 years. 54% reported a system in place to calculate maximum capacity, but testing of surge capacity was uncommon. 55% reported the presence of stored resources for an MCI and 58% had a database of staff trained in Emergency Management. 74% had a training and education plan available for staff involved in an MCI and a plan for professional debriefing of staff post-MCI, while 62% had a post-disaster employee assistance programme. Most centres had appropriate back-up communication, safety and security plans. INTERPRETATION: The disaster preparedness of MTCs was high for communication, safety and security but there was clear need for improvement in other areas including surge capacity, human resources and post-disaster recovery.
Published: 2020

36. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study

Author: Groeneweg, S, van Geest, FS, Abaci, A, Alcantud, A, Ambegaonkar, GP, Armour, CM, Bakhtiani, P, Barca, D, Bertini, ES, van Beynum, IM, Brunetti-Pierri, N, Bugiani, M, Cappa, M, Cappuccio, G, Castellotti, B, Castiglioni, C, Chatterjee, K, de Coo, IFM, Coutant, R, Craiu, D, Crock, P, DeGoede, C, Demir, K, Dica, A, Dimitri, P, Dolcetta-Capuzzo, A, Dremmen, MHG, Dubey, R, Enderli, A, Fairchild, J, Gallichan, J, George, B, Gevers, EF, Hackenberg, A, Halasz, Z, Heinrich, B, Huynh, T, Klosowska, A, van der Knaap, MS, van der Knoop, MM, Konrad, D, Koolen, DA, Krude, H, Lawson-Yuen, A, Lebl, J, Linder-Lucht, M, Lorea, CF, Lourenco, CM, Lunsing, RJ, Lyons, G, Malikova, J, Mancilla, EE, McGowan, A, Mericq, V, Lora, FM, Moran, C, Mueller, KE, Oliver-Petit, I, Paone, L, Paul, PG, Polak, M, Porta, F, Poswar, FO, Reinauer, C, Rozenkova, K, Menevse, TS, Simm, P, Simon, A, Singh, Y, Spada, M, van der Spek, J, Stals, MAM, Stoupa, A, Subramanian, GM, Tonduti, D, Turan, S, den Uil, CA, Vanderniet, J, van der Walt, A, Wemeau, J-L, Wierzba, J, de Wit, M-CY, Wolf, N, Wurm, M, Zibordi, F, Zung, A, Zwaveling-Soonawala, N, Visser, WE, Groeneweg, S, van Geest, FS, Abaci, A, Alcantud, A, Ambegaonkar, GP, Armour, CM, Bakhtiani, P, Barca, D, Bertini, ES, van Beynum, IM, Brunetti-Pierri, N, Bugiani, M, Cappa, M, Cappuccio, G, Castellotti, B, Castiglioni, C, Chatterjee, K, de Coo, IFM, Coutant, R, Craiu, D, Crock, P, DeGoede, C, Demir, K, Dica, A, Dimitri, P, Dolcetta-Capuzzo, A, Dremmen, MHG, Dubey, R, Enderli, A, Fairchild, J, Gallichan, J, George, B, Gevers, EF, Hackenberg, A, Halasz, Z, Heinrich, B, Huynh, T, Klosowska, A, van der Knaap, MS, van der Knoop, MM, Konrad, D, Koolen, DA, Krude, H, Lawson-Yuen, A, Lebl, J, Linder-Lucht, M, Lorea, CF, Lourenco, CM, Lunsing, RJ, Lyons, G, Malikova, J, Mancilla, EE, McGowan, A, Mericq, V, Lora, FM, Moran, C, Mueller, KE, Oliver-Petit, I, Paone, L, Paul, PG, Polak, M, Porta, F, Poswar, FO, Reinauer, C, Rozenkova, K, Menevse, TS, Simm, P, Simon, A, Singh, Y, Spada, M, van der Spek, J, Stals, MAM, Stoupa, A, Subramanian, GM, Tonduti, D, Turan, S, den Uil, CA, Vanderniet, J, van der Walt, A, Wemeau, J-L, Wierzba, J, de Wit, M-CY, Wolf, N, Wurm, M, Zibordi, F, Zung, A, Zwaveling-Soonawala, N, and Visser, WE
Abstract: BACKGROUND: Disordered thyroid hormone transport, due to mutations in the SLC16A2 gene encoding monocarboxylate transporter 8 (MCT8), is characterised by intellectual and motor disability resulting from cerebral hypothyroidism and chronic peripheral thyrotoxicosis. We sought to systematically assess the phenotypic characteristics and natural history of patients with MCT8 deficiency. METHODS: We did an international, multicentre, cohort study, analysing retrospective data from Jan 1, 2003, to Dec 31, 2019, from patients with MCT8 deficiency followed up in 47 hospitals in 22 countries globally. The key inclusion criterion was genetically confirmed MCT8 deficiency. There were no exclusion criteria. Our primary objective was to analyse the overall survival of patients with MCT8 deficiency and document causes of death. We also compared survival between patients who did or did not attain full head control by age 1·5 years and between patients who were or were not underweight by age 1-3 years (defined as a bodyweight-for-age Z score <-2 SDs or <5th percentile according to WHO definition). Other objectives were to assess neurocognitive function and outcomes, and clinical parameters including anthropometric characteristics, biochemical markers, and neuroimaging findings. FINDINGS: Between Oct 14, 2014, and Jan 17, 2020, we enrolled 151 patients with 73 different MCT8 (SLC16A2) mutations. Median age at diagnosis was 24·0 months (IQR 12·0-60·0, range 0·0-744·0). 32 (21%) of 151 patients died; the main causes of mortality in these patients were pulmonary infection (six [19%]) and sudden death (six [19%]). Median overall survival was 35·0 years (95% CI 8·3-61·7). Individuals who did not attain head control by age 1·5 years had an increased risk of death compared with patients who did attain head control (hazard ratio [HR] 3·46, 95% CI 1·76-8·34; log-rank test p=0·0041). Patients who were underweight during age 1-3 years had an increased risk for death compared with patients who
Published: 2020

37. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study

Author: Groeneweg, S., Geest, F.S. van, Abaci, A., Alcantud, A., Ambegaonkar, G.P., Armour, C.M., Bakhtiani, P., Barca, D., Bertini, E.S., Beijnum, I.M. van, Brunetti-Pierri, N., Bugiani, M., Cappa, M., Cappuccio, G., Castellotti, B., Castiglioni, C., Chatterjee, K., Coo, I.F.M. de, Coutant, R., Craiu, D., Crock, P., DeGoede, C., Demir, K., Dica, A., Dimitri, P., Dolcetta-Capuzzo, A., Dremmen, M.H.G., Dubey, R., Enderli, A., Fairchild, J., Gallichan, J., George, B., Gevers, E.F., Hackenberg, A., Halasz, Z., Heinrich, B., Huynh, T., Klosowska, A., Knaap, M.S. van der, Knoop, M.M. van der, Konrad, D., Koolen, D.A., Krude, H., Lawson-Yuen, A., Lebl, J., Linder-Lucht, M., Lorea, C.F., Lourenco, C.M., Lunsing, R.J., Lyons, G., Malikova, J., Mancilla, E.E., McGowan, A., Mericq, V., Lora, F.M., Moran, C., Muller, K.E., Oliver-Petit, I., Paone, L., Paul, P.G., Polak, M, Porta, F., Poswar, F.O., Reinauer, C., Rozenkova, K., Menevse, T.S., Simm, P., Simon, A., Singh, Y., Spada, M., Spek, J. van der, Stals, M.A.M., Stoupa, A., Subramanian, G.M., Tonduti, D., Turan, S., Uil, C.A. den, Vanderniet, J., Walt, A. van der, Wemeau, J.L., Wierzba, J., Wit, M.Y. de, Wolf, N.I., Wurm, M., Zibordi, F., Zung, A., Zwaveling-Soonawala, N., Visser, Wesley J., Groeneweg, S., Geest, F.S. van, Abaci, A., Alcantud, A., Ambegaonkar, G.P., Armour, C.M., Bakhtiani, P., Barca, D., Bertini, E.S., Beijnum, I.M. van, Brunetti-Pierri, N., Bugiani, M., Cappa, M., Cappuccio, G., Castellotti, B., Castiglioni, C., Chatterjee, K., Coo, I.F.M. de, Coutant, R., Craiu, D., Crock, P., DeGoede, C., Demir, K., Dica, A., Dimitri, P., Dolcetta-Capuzzo, A., Dremmen, M.H.G., Dubey, R., Enderli, A., Fairchild, J., Gallichan, J., George, B., Gevers, E.F., Hackenberg, A., Halasz, Z., Heinrich, B., Huynh, T., Klosowska, A., Knaap, M.S. van der, Knoop, M.M. van der, Konrad, D., Koolen, D.A., Krude, H., Lawson-Yuen, A., Lebl, J., Linder-Lucht, M., Lorea, C.F., Lourenco, C.M., Lunsing, R.J., Lyons, G., Malikova, J., Mancilla, E.E., McGowan, A., Mericq, V., Lora, F.M., Moran, C., Muller, K.E., Oliver-Petit, I., Paone, L., Paul, P.G., Polak, M, Porta, F., Poswar, F.O., Reinauer, C., Rozenkova, K., Menevse, T.S., Simm, P., Simon, A., Singh, Y., Spada, M., Spek, J. van der, Stals, M.A.M., Stoupa, A., Subramanian, G.M., Tonduti, D., Turan, S., Uil, C.A. den, Vanderniet, J., Walt, A. van der, Wemeau, J.L., Wierzba, J., Wit, M.Y. de, Wolf, N.I., Wurm, M., Zibordi, F., Zung, A., Zwaveling-Soonawala, N., and Visser, Wesley J.
Abstract: Contains fulltext : 220431.pdf (Publisher’s version ) (Closed access), BACKGROUND: Disordered thyroid hormone transport, due to mutations in the SLC16A2 gene encoding monocarboxylate transporter 8 (MCT8), is characterised by intellectual and motor disability resulting from cerebral hypothyroidism and chronic peripheral thyrotoxicosis. We sought to systematically assess the phenotypic characteristics and natural history of patients with MCT8 deficiency. METHODS: We did an international, multicentre, cohort study, analysing retrospective data from Jan 1, 2003, to Dec 31, 2019, from patients with MCT8 deficiency followed up in 47 hospitals in 22 countries globally. The key inclusion criterion was genetically confirmed MCT8 deficiency. There were no exclusion criteria. Our primary objective was to analyse the overall survival of patients with MCT8 deficiency and document causes of death. We also compared survival between patients who did or did not attain full head control by age 1.5 years and between patients who were or were not underweight by age 1-3 years (defined as a bodyweight-for-age Z score <-2 SDs or <5th percentile according to WHO definition). Other objectives were to assess neurocognitive function and outcomes, and clinical parameters including anthropometric characteristics, biochemical markers, and neuroimaging findings. FINDINGS: Between Oct 14, 2014, and Jan 17, 2020, we enrolled 151 patients with 73 different MCT8 (SLC16A2) mutations. Median age at diagnosis was 24.0 months (IQR 12.0-60.0, range 0.0-744.0). 32 (21%) of 151 patients died; the main causes of mortality in these patients were pulmonary infection (six [19%]) and sudden death (six [19%]). Median overall survival was 35.0 years (95% CI 8.3-61.7). Individuals who did not attain head control by age 1.5 years had an increased risk of death compared with patients who did attain head control (hazard ratio [HR] 3.46, 95% CI 1.76-8.34; log-rank test p=0.0041). Patients who were underweight during age 1-3 years had an increased risk for death compared with patients who
Published: 2020

38. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Author: Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., Claesson, M. J., Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.
Published: 2020

39. Searching for Anisotropic Cosmic Birefringence with Polarization Data from SPTpol

Author: Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., and Yefremenko, V.
Abstract: We present a search for anisotropic cosmic birefringence in 500 deg$^2$ of southern sky observed at 150 GHz with the SPTpol camera on the South Pole Telescope. We reconstruct a map of cosmic polarization rotation anisotropies using higher-order correlations between the observed cosmic microwave background (CMB) $E$ and $B$ fields. We then measure the angular power spectrum of this map, which is found to be consistent with zero. The non-detection is translated into an upper limit on the amplitude of the scale-invariant cosmic rotation power spectrum, $L(L+1)C_L^{\alpha\alpha}/2\pi < 0.10 \times 10^{-4}$ rad$^2$ (0.033 deg$^2$, 95% C.L.). This upper limit can be used to place constraints on the strength of primordial magnetic fields, $B_{1 \rm Mpc} < 17 {\rm nG} $ (95% C.L.), and on the coupling constant of the Chern-Simons electromagnetic term $g_{a\gamma} < 4.0 \times 10^{-2}/H_I $ (95% C.L.), where $H_I$ is the inflationary Hubble scale. For the first time, we also cross-correlate the CMB temperature fluctuations with the reconstructed rotation angle map, a signal expected to be non-vanishing in certain theoretical scenarios, and find no detectable signal. We perform a suite of systematics and consistency checks and find no evidence for contamination., Comment: 17 pages, 7 figures - new subsection on non-Gaussian foregrounds, conclusions unchanged - updated to match published version on PRD
Published: 2020
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40. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Author: Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., Claesson, M. J., Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.
Published: 2020

41. Optimal CMB Lensing Reconstruction and Parameter Estimation with SPTpol Data

Author: Millea, M., Daley, C. M., Chou, T-L., Anderes, E., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Goeckner-Wald, N., Guns, S., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., McMahon, J. J., Meyer, S. S., Mocanu, L. M., Montgomery, J., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Smecher, G., Stark, A. A., Thorne, B., Tucker, C., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Millea, M., Daley, C. M., Chou, T-L., Anderes, E., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Goeckner-Wald, N., Guns, S., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., McMahon, J. J., Meyer, S. S., Mocanu, L. M., Montgomery, J., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Smecher, G., Stark, A. A., Thorne, B., Tucker, C., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., and Yefremenko, V.
Abstract: We perform the first simultaneous Bayesian parameter inference and optimal reconstruction of the gravitational lensing of the cosmic microwave background (CMB), using 100 deg$^2$ of polarization observations from the SPTpol receiver on the South Pole Telescope. These data reach noise levels as low as 5.8 $\mu$K-arcmin in polarization, which are low enough that the typically used quadratic estimator (QE) technique for analyzing CMB lensing is significantly sub-optimal. Conversely, the Bayesian procedure extracts all lensing information from the data and is optimal at any noise level. We infer the amplitude of the gravitational lensing potential to be $A_\phi\,{=}\,0.949\,{\pm}\,0.122$ using the Bayesian pipeline, consistent with our QE pipeline result, but with 17\% smaller error bars. The Bayesian analysis also provides a simple way to account for systematic uncertainties, performing a similar job as frequentist "bias hardening," and reducing the systematic uncertainty on $A_\phi$ due to polarization calibration from almost half of the statistical error to effectively zero. Finally, we jointly constrain $A_\phi$ along with $A_{\rm L}$, the amplitude of lensing-like effects on the CMB power spectra, demonstrating that the Bayesian method can be used to easily infer parameters both from an optimal lensing reconstruction and from the delensed CMB, while exactly accounting for the correlation between the two. These results demonstrate the feasibility of the Bayesian approach on real data, and pave the way for future analysis of deep CMB polarization measurements with SPT-3G, Simons Observatory, and CMB-S4, where improvements relative to the QE can reach 1.5 times tighter constraints on $A_\phi$ and 7 times lower effective lensing reconstruction noise., Comment: 27 pages, 14 figures, accompanying software package available at https://cosmicmar.com/CMBLensing.jl
Published: 2020
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42. A Demonstration of Improved Constraints on Primordial Gravitational Waves with Delensing

Author: BICEP/Keck, Collaborations, SPTpol, Ade, P. A. R., Ahmed, Z., Amiri, M., Anderson, A. J., Austermann, J. E., Avva, J. S., Barkats, D., Thakur, R. Basu, Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bischoff, C. A., Bleem, L. E., Bock, J. J., Boenish, H., Bullock, E., Buza, V., Carlstrom, J. E., Chang, C. L., Cheshire IV, J. R., Chiang, H. C., Chou, T-L., Citron, R., Connors, J., Moran, C. Corbett, Cornelison, J., Crawford, T. M., Crites, A. T., Crumrine, M., Cukierman, A., de Haan, T., Dierickx, M., Dobbs, M. A., Duband, L., Everett, W., Fatigoni, S., Filippini, J. P., Fliescher, S., Gallicchio, J., George, E. M., Germaine, T. St., Goeckner-Wald, N., Goldfinger, D. C., Grayson, J., Gupta, N., Hall, G., Halpern, M., Halverson, N. W., Harrison, S., Henderson, S., Henning, J. W., Hildebrandt, S. R., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Hui, H., Irwin, K. D., Kang, J., Karkare, K. S., Karpel, E., Kefeli, S., Kernasovskiy, S. A., Knox, L., Kovac, J. M., Kuo, C. L., Lau, K., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Megerian, K. G., Meyer, S. S., Millea, M., Mocanu, L. M., Moncelsi, L., Montgomery, J., Nadolski, A., Namikawa, T., Natoli, T., Netterfield, C. B., Nguyen, H. T., Nibarger, J. P., Noble, G., Novosad, V., O'Brient, R., Ogburn IV, R. W., Omori, Y., Padin, S., Palladino, S., Patil, S., Prouve, T., Pryke, C., Racine, B., Reichardt, C. L., Reintsema, C. D., Richter, S., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Schillaci, A., Schmitt, B. L., Schwarz, R., Sheehy, C. D., Sievers, C., Smecher, G., Soliman, A., Stark, A. A., Steinbach, B., Sudiwala, R. V., Teply, G. P., Thompson, K. L., Tolan, J. E., Tucker, C., Turner, A. D., Umiltà, C., Veach, T., Vieira, J. D., Vieregg, A. G., Wandui, A., Wang, G., Weber, A. C., Whitehorn, N., Wiebe, D. V., Willmert, J., Wong, C. L., Wu, W. L. K., Yang, H., Yefremenko, V., Yoon, K. W., Young, E., Yu, C., Zeng, L., Zhang, C., BICEP/Keck, Collaborations, SPTpol, Ade, P. A. R., Ahmed, Z., Amiri, M., Anderson, A. J., Austermann, J. E., Avva, J. S., Barkats, D., Thakur, R. Basu, Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bischoff, C. A., Bleem, L. E., Bock, J. J., Boenish, H., Bullock, E., Buza, V., Carlstrom, J. E., Chang, C. L., Cheshire IV, J. R., Chiang, H. C., Chou, T-L., Citron, R., Connors, J., Moran, C. Corbett, Cornelison, J., Crawford, T. M., Crites, A. T., Crumrine, M., Cukierman, A., de Haan, T., Dierickx, M., Dobbs, M. A., Duband, L., Everett, W., Fatigoni, S., Filippini, J. P., Fliescher, S., Gallicchio, J., George, E. M., Germaine, T. St., Goeckner-Wald, N., Goldfinger, D. C., Grayson, J., Gupta, N., Hall, G., Halpern, M., Halverson, N. W., Harrison, S., Henderson, S., Henning, J. W., Hildebrandt, S. R., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Hui, H., Irwin, K. D., Kang, J., Karkare, K. S., Karpel, E., Kefeli, S., Kernasovskiy, S. A., Knox, L., Kovac, J. M., Kuo, C. L., Lau, K., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Megerian, K. G., Meyer, S. S., Millea, M., Mocanu, L. M., Moncelsi, L., Montgomery, J., Nadolski, A., Namikawa, T., Natoli, T., Netterfield, C. B., Nguyen, H. T., Nibarger, J. P., Noble, G., Novosad, V., O'Brient, R., Ogburn IV, R. W., Omori, Y., Padin, S., Palladino, S., Patil, S., Prouve, T., Pryke, C., Racine, B., Reichardt, C. L., Reintsema, C. D., Richter, S., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Schillaci, A., Schmitt, B. L., Schwarz, R., Sheehy, C. D., Sievers, C., Smecher, G., Soliman, A., Stark, A. A., Steinbach, B., Sudiwala, R. V., Teply, G. P., Thompson, K. L., Tolan, J. E., Tucker, C., Turner, A. D., Umiltà, C., Veach, T., Vieira, J. D., Vieregg, A. G., Wandui, A., Wang, G., Weber, A. C., Whitehorn, N., Wiebe, D. V., Willmert, J., Wong, C. L., Wu, W. L. K., Yang, H., Yefremenko, V., Yoon, K. W., Young, E., Yu, C., Zeng, L., and Zhang, C.
Abstract: We present a constraint on the tensor-to-scalar ratio, $r$, derived from measurements of cosmic microwave background (CMB) polarization $B$-modes with "delensing," whereby the uncertainty on $r$ contributed by the sample variance of the gravitational lensing $B$-modes is reduced by cross-correlating against a lensing $B$-mode template. This template is constructed by combining an estimate of the polarized CMB with a tracer of the projected large-scale structure. The large-scale-structure tracer used is a map of the cosmic infrared background derived from Planck satellite data, while the polarized CMB map comes from a combination of South Pole Telescope, BICEP/Keck, and Planck data. We expand the BICEP/Keck likelihood analysis framework to accept a lensing template and apply it to the BICEP/Keck data set collected through 2014 using the same parametric foreground modelling as in the previous analysis. From simulations, we find that the uncertainty on $r$ is reduced by $\sim10\%$, from $\sigma(r)$= 0.024 to 0.022, which can be compared with a $\sim26\%$ reduction obtained when using a perfect lensing template. Applying the technique to the real data, the constraint on $r$ is improved from $r_{0.05} < 0.090$ to $r_{0.05} < 0.082$ (95\% C.L.). This is the first demonstration of improvement in an $r$ constraint through delensing., Comment: 23 pages, 11 figures; match published version
Published: 2020
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43. Searching for Anisotropic Cosmic Birefringence with Polarization Data from SPTpol

Author: Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., and Yefremenko, V.
Abstract: We present a search for anisotropic cosmic birefringence in 500 deg$^2$ of southern sky observed at 150 GHz with the SPTpol camera on the South Pole Telescope. We reconstruct a map of cosmic polarization rotation anisotropies using higher-order correlations between the observed cosmic microwave background (CMB) $E$ and $B$ fields. We then measure the angular power spectrum of this map, which is found to be consistent with zero. The non-detection is translated into an upper limit on the amplitude of the scale-invariant cosmic rotation power spectrum, $L(L+1)C_L^{\alpha\alpha}/2\pi < 0.10 \times 10^{-4}$ rad$^2$ (0.033 deg$^2$, 95% C.L.). This upper limit can be used to place constraints on the strength of primordial magnetic fields, $B_{1 \rm Mpc} < 17 {\rm nG} $ (95% C.L.), and on the coupling constant of the Chern-Simons electromagnetic term $g_{a\gamma} < 4.0 \times 10^{-2}/H_I $ (95% C.L.), where $H_I$ is the inflationary Hubble scale. For the first time, we also cross-correlate the CMB temperature fluctuations with the reconstructed rotation angle map, a signal expected to be non-vanishing in certain theoretical scenarios, and find no detectable signal. We perform a suite of systematics and consistency checks and find no evidence for contamination., Comment: 17 pages, 7 figures - new subsection on non-Gaussian foregrounds, conclusions unchanged - updated to match published version on PRD
Published: 2020
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44. An Improved Measurement of the Secondary Cosmic Microwave Background Anisotropies from the SPT-SZ + SPTpol Surveys

Author: Reichardt, C. L., Patil, S., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Luong-Van, D., McMahon, J. J., Mehl, J., Meyer, S. S., Millea, M., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Sievers, C., Smecher, G., Spieler, H. G., Staniszewski, Z., Stark, A. A., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Williamson, R., Wu, W. L. K., Yefremenko, V., Reichardt, C. L., Patil, S., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Luong-Van, D., McMahon, J. J., Mehl, J., Meyer, S. S., Millea, M., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Sievers, C., Smecher, G., Spieler, H. G., Staniszewski, Z., Stark, A. A., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Williamson, R., Wu, W. L. K., and Yefremenko, V.
Abstract: We report new measurements of millimeter-wave power spectra in the angular multipole range $2000 \le \ell \le 11,000$ (angular scales $5^\prime \gtrsim \theta \gtrsim 1^\prime$). By adding 95 and 150\,GHz data from the low-noise 500 deg$^2$ SPTpol survey to the SPT-SZ three-frequency 2540 deg$^2$ survey, we substantially reduce the uncertainties in these bands. These power spectra include contributions from the primary cosmic microwave background, cosmic infrared background, radio galaxies, and thermal and kinematic Sunyaev-Zel'dovich (SZ) effects. The data favor a thermal SZ (tSZ) power at 143\,GHz of $D^{\rm tSZ}_{3000} = 3.42 \pm 0.54~ \mu {\rm K}^2$ and a kinematic SZ (kSZ) power of $D^{\rm kSZ}_{3000} = 3.0 \pm 1.0~ \mu {\rm K}^2$. This is the first measurement of kSZ power at $\ge 3\,\sigma$. We study the implications of the measured kSZ power for the epoch of reionization, finding the duration of reionization to be $\Delta z_{re} = 1.0^{+1.6}_{-0.7}$ ($\Delta z_{re}< 4.1$ at 95% confidence), when combined with our previously published tSZ bispectrum measurement., Comment: Submitted to ApJ, 16 pages. (revised portions of the introduction and description of bandpower estimation)
Published: 2020
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45. Familial dysalbuminaemic hyperthyroxinaemia interferes with current free thyroid hormone immunoassay methods

Author: Khoo, S, Lyons, G, McGowan, A, Gurnell, M, Oddy, S, Visser, Edward, van den Berg, Sjoerd, Halsall, D, Taylor, K, Chatterjee, K, Moran, C, Khoo, S, Lyons, G, McGowan, A, Gurnell, M, Oddy, S, Visser, Edward, van den Berg, Sjoerd, Halsall, D, Taylor, K, Chatterjee, K, and Moran, C
Published: 2020

46. Blood pressure, aortic stiffness, hemodynamics and cognition in twin pairs discordant for type 2 diabetes

Author: Karayiannis, C, Moran, C, Sharman, J E, Beare, R, Quinn, S J, Phan, T G, Wood, Amanda, Thrift, A G, Wang, W C, Srikanth, V, Karayiannis, C, Moran, C, Sharman, J E, Beare, R, Quinn, S J, Phan, T G, Wood, Amanda, Thrift, A G, Wang, W C, and Srikanth, V
Abstract: Background: Type 2 diabetes (T2D) is associated with an increased risk of cognitive impairment and dementia with poorly understood underlying mechanisms. Objective: We examined the role of blood pressure (BP), aortic stiffness, and hemodynamics in this association. Methods: Cross-sectional sample of late middle-aged twins discordant for T2D from the Australian Twin Registry. Measurements included neuropsychological battery and brain MRI including arterial spin labelling (ASL) to measure cerebral perfusion. Mobil-o-Graph devices were used to non-invasively obtain 24-hour BP, aortic stiffness, and hemodynamic measures. Using mixed modelling, we studied associations of T2D with cognition, MRI measures, BP, aortic stiffness, and hemodynamics. Results: There were 23 twin pairs with mean age 63.7 (SD = 6.1) years. T2D (β=-0.45, p < 0.001) and age (β=-0.05, p = 0.022) were independently associated with poorer attention but not with memory or perceptual speed. T2D was associated with reduced nocturnal central systolic BP dipping (β=-3.79, p = 0.027), but not with BP, aortic stiffness, cerebral perfusion, or other hemodynamic measures. There was a statistically significant interaction between T2D and central systolic BP dipping in predicting attention scores (both p < 0.05 for the interaction term) whereby there was a positive association between BP dipping and attention scores in those with T2D, but not in those without T2D. Conclusion: We found an association between T2D and reduced nocturnal central systolic dipping, but not with any other measures of BP, stiffness or hemodynamic measures. Further study of the role of nocturnal central BP dipping in the association between T2D and cognitive impairment may help identify potential mechanisms.
Published: 2019

47. Blood pressure, aortic stiffness, hemodynamics and cognition in twin pairs discordant for type 2 diabetes

Author: Karayiannis, C, Moran, C, Sharman, J E, Beare, R, Quinn, S J, Phan, T G, Wood, Amanda, Thrift, A G, Wang, W C, Srikanth, V, Karayiannis, C, Moran, C, Sharman, J E, Beare, R, Quinn, S J, Phan, T G, Wood, Amanda, Thrift, A G, Wang, W C, and Srikanth, V
Abstract: Background: Type 2 diabetes (T2D) is associated with an increased risk of cognitive impairment and dementia with poorly understood underlying mechanisms. Objective: We examined the role of blood pressure (BP), aortic stiffness, and hemodynamics in this association. Methods: Cross-sectional sample of late middle-aged twins discordant for T2D from the Australian Twin Registry. Measurements included neuropsychological battery and brain MRI including arterial spin labelling (ASL) to measure cerebral perfusion. Mobil-o-Graph devices were used to non-invasively obtain 24-hour BP, aortic stiffness, and hemodynamic measures. Using mixed modelling, we studied associations of T2D with cognition, MRI measures, BP, aortic stiffness, and hemodynamics. Results: There were 23 twin pairs with mean age 63.7 (SD = 6.1) years. T2D (β=-0.45, p < 0.001) and age (β=-0.05, p = 0.022) were independently associated with poorer attention but not with memory or perceptual speed. T2D was associated with reduced nocturnal central systolic BP dipping (β=-3.79, p = 0.027), but not with BP, aortic stiffness, cerebral perfusion, or other hemodynamic measures. There was a statistically significant interaction between T2D and central systolic BP dipping in predicting attention scores (both p < 0.05 for the interaction term) whereby there was a positive association between BP dipping and attention scores in those with T2D, but not in those without T2D. Conclusion: We found an association between T2D and reduced nocturnal central systolic dipping, but not with any other measures of BP, stiffness or hemodynamic measures. Further study of the role of nocturnal central BP dipping in the association between T2D and cognitive impairment may help identify potential mechanisms.
Published: 2019

48. Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial

Author: Groeneweg, S., Peeters, R.P., Moran, C., Stoupa, A., Auriol, F., Tonduti, D., Dica, A., Paone, L., Rozenkova, K., Malikova, J., Walt, A. van der, Coo, I.F.M. de, McGowan, A., Lyons, G., Aarsen, F.K., Barca, D., Beynum, I.M. van, Knoop, M.M. van der, Jansen, J, Manshande, M., Lunsing, R.J., Nowak, S., Uil, C.A. den, Zillikens, M.C., Visser, F.E., Vrijmoeth, P., Wit, M.C. de, Wolf, N.I., Zandstra, A., Ambegaonkar, G., Singh, Y., Rijke, Y.B. de, Medici, M., Bertini, E.S., Depoorter, S., Lebl, J., Cappa, M., Meirleir, L. de, Krude, H., Craiu, D., Zibordi, F., Petit, I., Polak, M, Chatterjee, K., Visser, T.J., Visser, W.E., Groeneweg, S., Peeters, R.P., Moran, C., Stoupa, A., Auriol, F., Tonduti, D., Dica, A., Paone, L., Rozenkova, K., Malikova, J., Walt, A. van der, Coo, I.F.M. de, McGowan, A., Lyons, G., Aarsen, F.K., Barca, D., Beynum, I.M. van, Knoop, M.M. van der, Jansen, J, Manshande, M., Lunsing, R.J., Nowak, S., Uil, C.A. den, Zillikens, M.C., Visser, F.E., Vrijmoeth, P., Wit, M.C. de, Wolf, N.I., Zandstra, A., Ambegaonkar, G., Singh, Y., Rijke, Y.B. de, Medici, M., Bertini, E.S., Depoorter, S., Lebl, J., Cappa, M., Meirleir, L. de, Krude, H., Craiu, D., Zibordi, F., Petit, I., Polak, M, Chatterjee, K., Visser, T.J., and Visser, W.E.
Abstract: Contains fulltext : 215609.pdf (publisher's version ) (Closed access), BACKGROUND: Deficiency of the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) causes severe intellectual and motor disability and high serum tri-iodothyronine (T3) concentrations (Allan-Herndon-Dudley syndrome). This chronic thyrotoxicosis leads to progressive deterioration in bodyweight, tachycardia, and muscle wasting, predisposing affected individuals to substantial morbidity and mortality. Treatment that safely alleviates peripheral thyrotoxicosis and reverses cerebral hypothyroidism is not yet available. We aimed to investigate the effects of treatment with the T3 analogue Triac (3,3',5-tri-iodothyroacetic acid, or tiratricol), in patients with MCT8 deficiency. METHODS: In this investigator-initiated, multicentre, open-label, single-arm, phase 2, pragmatic trial, we investigated the effectiveness and safety of oral Triac in male paediatric and adult patients with MCT8 deficiency in eight countries in Europe and one site in South Africa. Triac was administered in a predefined escalating dose schedule-after the initial dose of once-daily 350 mug Triac, the daily dose was increased progressively in 350 mug increments, with the goal of attaining serum total T3 concentrations within the target range of 1.4-2.5 nmol/L. We assessed changes in several clinical and biochemical signs of hyperthyroidism between baseline and 12 months of treatment. The prespecified primary endpoint was the change in serum T3 concentrations from baseline to month 12. The co-primary endpoints were changes in concentrations of serum thyroid-stimulating hormone (TSH), free and total thyroxine (T4), and total reverse T3 from baseline to month 12. These analyses were done in patients who received at least one dose of Triac and had at least one post-baseline evaluation of serum throid function. This trial is registered with ClinicalTrials.gov, number NCT02060474. FINDINGS: Between Oct 15, 2014, and June 1, 2017, we screened 50 patients, all of whom were eligible. Of these patient
Published: 2019

49. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Author: Jung S., van Dam-Nolen D.H.K., Douven E., Delgado-Mederos, R., Marin R., Camps-Renom P., Guisado-Alonso D., Nunez F., Medrano-Martorell S., Merino E., Iida K., Ikeda S., Nishihara M., Irie H., Demirelli D.S., Medanta J.M., Zerna C., Hernandez M.V., Armitage P., Heye A., Munoz-Maniega S., Sakka E., Thrippleton M., Dennis M., Beigneux Y., Silva M., Venketasubramanian N., Ho S.L., Cheung R.T.F., Chan K.H., Teo K.C., Hui E., Kwan J.S.K., Chang R., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Leung K.T., Tsang S.F., Ip H.L., Ma S.H., Ma K., Fong W.C., Li S.H., Li R., Ng P.W., Wong K.K., Liu W., Wong L., Ramos L., De Schryver E., Jobsis J., van der Sande J., Brouwers P., Roos Y., Stam J., Bakker S., Verbiest H., Schoonewille W., Linn C., Hertzberger L., van Gemert M., Berntsen P., Hendrikse J., Nederkoorn P., Mess W., Koudstaal P., Leff A., Ward N., Nachev P., Perry R., Ozkan H., Mitchell J., Wilson D., Ambler G., Lee K.-J., Lim J.-S., Shiozawa M., Koga M., Li L., Lovelock C., Chabriat H., Hennerici M., Wong Y.K., Mak H.K.F., Prats-Sanchez L., Martinez-Domeno A., Inamura S., Yoshifuji K., Arsava E.M., Horstmann S., Purrucker J., Lam B.Y.K., Wong A., Kim Y.D., Song T.-J., Schrooten M., Lemmens R., Eppinger S., Gattringer T., Uysal E., Tanriverdi Z., Bornstein N.M., Assayag E.B., Hallevi H., Tanaka J., Hara H., Coutts S.B., Hert L., Polymeris A., Seiffge D.J., Lyrer P., Algra A., Kappelle J., Al-Shahi Salman R., Jager H.R., Lip G.Y.H., Mattle H.P., Panos L.D., Mas J.-L., Legrand L., Karayiannis C., Phan T., Gunkel S., Christ N., Abrigo J., Leung T., Chu W., Chappell F., Makin S., Hayden D., Williams D.J., Kooi M.E., Barbato C., Browning S., Wiegertjes K., Tuladhar A.M., Maaijwee N., Guevarra C., Yatawara C., Mendyk A.-M., Delmaire C., Kohler S., van Oostenbrugge R., Zhou Y., Xu C., Hilal S., Gyanwali B., Chen C., Lou M., Staals J., Bordet R., Kandiah N., de Leeuw F.-E., Simister R., van der Lugt A., Kelly P.J., Wardlaw J.M., Soo Y., Fluri F., Srikanth V., Calvet D., Kwa V.I.H., Engelter S.T., Peters N., Smith E.E., Yakushiji Y., Orken D.N., Fazekas F., Thijs V., Heo J.H., Mok V., Veltkamp R., Ay H., Imaizumi T., Gomez-Anson B., Lau K.K., Jouvent E., Rothwell P.M., Toyoda K., Bae H.-J., Marti-Fabregas J., Werring D.J., Harkness K., Shaw L., Sword J., Mohd Nor A., Sharma P., Kelly D., Harrington F., Randall M., Smith M., Mahawish K., Elmarim A., Esisi B., Cullen C., Nallasivam A., Price C., Barry A., Roffe C., Coyle J., Hassan A., Birns J., Cohen D., Sekaran L., Parry-Jones A., Parry A., Hargroves D., Proschel H., Datta P., Darawil K., Manoj A., Burn M., Patterson C., Giallombardo E., Smyth N., Mansoor S., Anwar I., Marsh R., Ispoglou S., Chadha D., Prabhakaran M., Meenakishundaram S., O'Connell J., Scott J., Krishnamurthy V., Aghoram P., McCormick M., Sprigg N., O'Mahony P., Cooper M., Choy L., Wilkinson P., Leach S., Caine S., Burger I., Gunathilagan G., Guyler P., Emsley H., Davis M., Manawadu D., Pasco K., Mamun M., Luder R., Sajid M., Okwera J., Warburton E., Saastamoinen K., England T., Putterill J., Flossman E., Power M., Dani K., Mangion D., Suman A., Corrigan J., Lawrence E., Vahidassr D., Shakeshaft C., Brown M., Charidimou A., Cohen H., Banerjee G., Houlden H., White M., Yousry T., Flossmann E., Muir K., El-Koussy M., Gratz P., Molad J., Korczyn A., Kliper E., Maeder P., Gass A., Pachai C., Bracoub L., Douste-Blazy M.-Y., Fratacci M.D., Vicaut E., Sato S., Miwa K., Fujita K., Ide T., Ma H., Ly J., Singhal S., Chandra R., Slater L.-A., Soufan C., Moran C., Traenka C., Thilemann S., Fladt J., Gensicke H., Bonati L., Kim B.J., Han M.-K., Kang J., Ko E., Yang M.H., Jang M.S., Murphy S., Carty F., Akijian L., Thornton J., Schembri M., Jung S., van Dam-Nolen D.H.K., Douven E., Delgado-Mederos, R., Marin R., Camps-Renom P., Guisado-Alonso D., Nunez F., Medrano-Martorell S., Merino E., Iida K., Ikeda S., Nishihara M., Irie H., Demirelli D.S., Medanta J.M., Zerna C., Hernandez M.V., Armitage P., Heye A., Munoz-Maniega S., Sakka E., Thrippleton M., Dennis M., Beigneux Y., Silva M., Venketasubramanian N., Ho S.L., Cheung R.T.F., Chan K.H., Teo K.C., Hui E., Kwan J.S.K., Chang R., Tse M.Y., Hoi C.P., Chan C.Y., Chan O.L., Cheung R.H.K., Wong E.K.M., Leung K.T., Tsang S.F., Ip H.L., Ma S.H., Ma K., Fong W.C., Li S.H., Li R., Ng P.W., Wong K.K., Liu W., Wong L., Ramos L., De Schryver E., Jobsis J., van der Sande J., Brouwers P., Roos Y., Stam J., Bakker S., Verbiest H., Schoonewille W., Linn C., Hertzberger L., van Gemert M., Berntsen P., Hendrikse J., Nederkoorn P., Mess W., Koudstaal P., Leff A., Ward N., Nachev P., Perry R., Ozkan H., Mitchell J., Wilson D., Ambler G., Lee K.-J., Lim J.-S., Shiozawa M., Koga M., Li L., Lovelock C., Chabriat H., Hennerici M., Wong Y.K., Mak H.K.F., Prats-Sanchez L., Martinez-Domeno A., Inamura S., Yoshifuji K., Arsava E.M., Horstmann S., Purrucker J., Lam B.Y.K., Wong A., Kim Y.D., Song T.-J., Schrooten M., Lemmens R., Eppinger S., Gattringer T., Uysal E., Tanriverdi Z., Bornstein N.M., Assayag E.B., Hallevi H., Tanaka J., Hara H., Coutts S.B., Hert L., Polymeris A., Seiffge D.J., Lyrer P., Algra A., Kappelle J., Al-Shahi Salman R., Jager H.R., Lip G.Y.H., Mattle H.P., Panos L.D., Mas J.-L., Legrand L., Karayiannis C., Phan T., Gunkel S., Christ N., Abrigo J., Leung T., Chu W., Chappell F., Makin S., Hayden D., Williams D.J., Kooi M.E., Barbato C., Browning S., Wiegertjes K., Tuladhar A.M., Maaijwee N., Guevarra C., Yatawara C., Mendyk A.-M., Delmaire C., Kohler S., van Oostenbrugge R., Zhou Y., Xu C., Hilal S., Gyanwali B., Chen C., Lou M., Staals J., Bordet R., Kandiah N., de Leeuw F.-E., Simister R., van der Lugt A., Kelly P.J., Wardlaw J.M., Soo Y., Fluri F., Srikanth V., Calvet D., Kwa V.I.H., Engelter S.T., Peters N., Smith E.E., Yakushiji Y., Orken D.N., Fazekas F., Thijs V., Heo J.H., Mok V., Veltkamp R., Ay H., Imaizumi T., Gomez-Anson B., Lau K.K., Jouvent E., Rothwell P.M., Toyoda K., Bae H.-J., Marti-Fabregas J., Werring D.J., Harkness K., Shaw L., Sword J., Mohd Nor A., Sharma P., Kelly D., Harrington F., Randall M., Smith M., Mahawish K., Elmarim A., Esisi B., Cullen C., Nallasivam A., Price C., Barry A., Roffe C., Coyle J., Hassan A., Birns J., Cohen D., Sekaran L., Parry-Jones A., Parry A., Hargroves D., Proschel H., Datta P., Darawil K., Manoj A., Burn M., Patterson C., Giallombardo E., Smyth N., Mansoor S., Anwar I., Marsh R., Ispoglou S., Chadha D., Prabhakaran M., Meenakishundaram S., O'Connell J., Scott J., Krishnamurthy V., Aghoram P., McCormick M., Sprigg N., O'Mahony P., Cooper M., Choy L., Wilkinson P., Leach S., Caine S., Burger I., Gunathilagan G., Guyler P., Emsley H., Davis M., Manawadu D., Pasco K., Mamun M., Luder R., Sajid M., Okwera J., Warburton E., Saastamoinen K., England T., Putterill J., Flossman E., Power M., Dani K., Mangion D., Suman A., Corrigan J., Lawrence E., Vahidassr D., Shakeshaft C., Brown M., Charidimou A., Cohen H., Banerjee G., Houlden H., White M., Yousry T., Flossmann E., Muir K., El-Koussy M., Gratz P., Molad J., Korczyn A., Kliper E., Maeder P., Gass A., Pachai C., Bracoub L., Douste-Blazy M.-Y., Fratacci M.D., Vicaut E., Sato S., Miwa K., Fujita K., Ide T., Ma H., Ly J., Singhal S., Chandra R., Slater L.-A., Soufan C., Moran C., Traenka C., Thilemann S., Fladt J., Gensicke H., Bonati L., Kim B.J., Han M.-K., Kang J., Ko E., Yang M.H., Jang M.S., Murphy S., Carty F., Akijian L., Thornton J., and Schembri M.
Abstract: Background: Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral microbleeds can identify ischaemic stroke or transient ischaemic attack patients at higher absolute risk of intracranial haemorrhage than ischaemic stroke. Method(s): We did a pooled analysis of individual patient data from cohort studies in adults with recent ischaemic stroke or transient ischaemic attack. Cohorts were eligible for inclusion if they prospectively recruited adult participants with ischaemic stroke or transient ischaemic attack; included at least 50 participants; collected data on stroke events over at least 3 months follow-up; used an appropriate MRI sequence that is sensitive to magnetic susceptibility; and documented the number and anatomical distribution of cerebral microbleeds reliably using consensus criteria and validated scales. Our prespecified primary outcomes were a composite of any symptomatic intracranial haemorrhage or ischaemic stroke, symptomatic intracranial haemorrhage, and symptomatic ischaemic stroke. We registered this study with the PROSPERO international prospective register of systematic reviews, number CRD42016036602. Finding(s): Between Jan 1, 1996, and Dec 1, 2018, we identified 344 studies. After exclusions for ineligibility or declined requests for inclusion, 20 322 patients from 38 cohorts (over 35 225 patient-years of follow-up; median 1.34 years [IQR 0.19-2.44]) were included in our analyses. The adjusted hazard ratio [aHR] comparing patients with cerebral microbleeds to those without was 1.35 (95% CI 1.20-1.50) for the composite outcome of
Published: 2019

50. EFFECTS OF AGING, SEX AND MENOPAUSE ON TOTAL BRAIN VOLUME AT MIDDLE AND EARLY OLD AGE.

Author: Wang W., Beare R., Vincent A., Srikanth V.K., Than S., Moran C., Wang W., Beare R., Vincent A., Srikanth V.K., Than S., and Moran C.
Abstract: Background: Greater age and female sex are risk factors for dementia. Menopause is associated with cognitive dysfunction and may contribute to dementia risk. Previous work has considered the effects of aging and menopause as additive. We aimed to study whether aging and menopause interact to amplify each other's effect on imaging biomarkers of dementia. Method(s): Cross-sectional study of participants with detailed structural brain magnetic resonance imaging data from the UK Biobank, a community-based cohort of men and women over 40 years of age in the United Kingdom. Using linear regression modeling we explored the associations of age, sex and menopausal status with total brain volume (TBV), examining for interactions, and adjusting for APOE4 status. Result(s): Data were available for 1824 postmenopausal women, 233 premenopausal women and 2165 men (median age 63.3, range 44.6-78.0 years). There was an interaction between sex and age (p<0.01) such that the negative association of age with TBV was greater in women (beta= -5.42, 95% CI: -5.75 to -5.10) than men (beta= -4.74, 95%CI: -5.54 to -3.94). In women, there was an interaction between menopausal status and age (p=0.01) such that the negative association of age with TBV was greater in post-menopausal women (beta= -5.89, 95% CI:-6.33 to -5.45) than pre-menopausal women (beta= -2.87, 95% CI:-5.70 to -0.04). Use of hormonal replacement therapy did not significantly alter this relationship. Conclusion(s): Increasing age, female sex, and the occurrence of menopause appears to have synergistic effects on TBV. Further work is required to understand the mechanisms driving these associations, to develop ways to prevent or delay neurodegeneration and dementia.Copyright © 2019
Published: 2019

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