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Research background. Wine production, which is considered a major sector in food industry, often involves the use of a large amount of resources. Moreover, wine making generates a large amount of grape pomace, which is generally used for low-value applications such as fertiliser and animal feed. The aim of the present research is to explore the possibility of improving the overall sustainability of traditional winemaking. Experimental approach. A zero-waste process was developed. It includes the production of white wine and the substantial valorisation of grape pomace, which is converted into solid biofuel, tartaric acid and concentrated grape extract as feedstock for industrial baker’s yeast production. Results and conclusions. We estimate that a significant surplus of renewable energy of approx. 3 MJ/kg processed grapes can be obtained during this conversion. The suitability of grape extract as a potential substrate for industrial baker’s yeast production was evaluated and the feasibility of a partial replacement of molasses (up to 30 %) was demonstrated. Novelty and scientific contribution. We present a circular economy approach for the conversion of winery biowaste into high-value resources such as feedstock and solid biofuel., Pozadina istraživanja. Proizvodnja vina, koja se smatra važnim sektorom u prehrambenoj industriji, često uključuje korištenje velikih resursa. Osim toga, nakon proizvodnje vina zaostaju velike količine komine grožđa, koja se obično koristi za dobivanje proizvoda niske vrijednosti, poput gnojiva ili stočne hrane. Svrha je ovog znanstvenog rada bila istražiti mogućnost poboljšanja ukupne održivosti tradicionalnog postupka proizvodnje vina. Eksperimentalni pristup. U radu je razvijen postupak koji uključuje proizvodnju bijelog vina i značajnu valorizaciju komine grožđa, koja se pretvara u čvrsto biogorivo, vinsku kiselinu i koncentrirani ekstrakt grožđa kao sirovinu za industrijsku proizvodnju pekarskog kvasca. Rezultati i zaključci. Procjenjujemo da se ovom metodom može dobiti značajan višak obnovljive energije od otprilike 3 MJ/kg obrađenog grožđa tijekom postupka. Istražena je moguća uporaba ekstrakta grožđa kao potencijalne sirovine u industrijskoj proizvodnji pekarskog kvasca, te je dokazana mogućnost djelomične zamjene melase s ekstraktom grožđa (do 30 %). Novina i znanstveni doprinos. U radu predstavljamo princip kružnog gospodarstva pri pretvaranju biološkog vinskog otpada u visokovrijedne resurse, poput sirovina i čvrstog biogoriva.

Climate change in Europe will lead to new precipitation patterns over the coming years and the annual temperature will increase significantly. These changes in climate variables and the resulting effects on agricultural productivity must be differentiated regionally. Plant production depends on sufficient rainfall in summer and, in some regions, on the amount of rainfall in winter. In Central Europe, the amount of precipitation in summer will decrease in the coming decades due to climate change, while in some regions, the amount of winter precipitation will increase significantly. Agricultural production is likely to suffer severely as a result of rising summer temperatures and low water retention capacities in the soil. The effects of reduced summer precipitation and increased air temperatures are partially offset by the expected increased CO2 concentration. Therefore, the effects that changed climatic conditions have on crop production are sometimes less drastic in terms of crop yields. The greatest impact of climate change on land use is expected from increasing evapotranspiration and lower amounts of precipitation in the production of leachate. In addition to the expected mean changes, the occurrence of extreme weather conditions is key. Periods of drought in the growing season and heavy flooding as a result of extreme rainfall are to be expected. However, these events are very difficult or even impossible to predict. In addition to the effects that climate change will have on regional crop production, global changes will have a strong impact on world markets for agricultural products. Another consequence of climate change and population growth is a higher demand for agricultural products on world markets. This will lead to dramatic local land use changes and an intensification of agriculture that will transform existing crop production systems. The intensification caused by rising land and lease prices will primarily affect the maximization of the use of fertil

Climate change in Europe will lead to new precipitation patterns over the coming years and the annual temperature will increase significantly. These changes in climate variables and the resulting effects on agricultural productivity must be differentiated regionally. Plant production depends on sufficient rainfall in summer and, in some regions, on the amount of rainfall in winter. In Central Europe, the amount of precipitation in summer will decrease in the coming decades due to climate change, while in some regions, the amount of winter precipitation will increase significantly. Agricultural production is likely to suffer severely as a result of rising summer temperatures and low water retention capacities in the soil. The effects of reduced summer precipitation and increased air temperatures are partially offset by the expected increased CO2 concentration. Therefore, the effects that changed climatic conditions have on crop production are sometimes less drastic in terms of crop yields. The greatest impact of climate change on land use is expected from increasing evapotranspiration and lower amounts of precipitation in the production of leachate. In addition to the expected mean changes, the occurrence of extreme weather conditions is key. Periods of drought in the growing season and heavy flooding as a result of extreme rainfall are to be expected. However, these events are very difficult or even impossible to predict. In addition to the effects that climate change will have on regional crop production, global changes will have a strong impact on world markets for agricultural products. Another consequence of climate change and population growth is a higher demand for agricultural products on world markets. This will lead to dramatic local land use changes and an intensification of agriculture that will transform existing crop production systems. The intensification caused by rising land and lease prices will primarily affect the maximization of the use of fertil

The 5th International Consensus Conference for Advanced Breast Cancer (ABC5) took place on November 14–16, 2019, in Lisbon, Portugal. Its aim is to standardize the treatment of advanced breast cancer based on the available evidence and to ensure that all breast cancer patients worldwide receive adequate treatment and access to new therapies. This year, the conference focused on developments and study results in the treatment of patients with hormone receptor-positive/HER2-negative breast cancer as well as precision medicine. As in previous years, patient advocates from around the world were integrated into the ABC conference and had seats on the ABC consensus panel. In the present paper, a working group of German breast cancer experts comments on the results of the on-site ABC5 consensus votes by ABC panelists regarding their applicability for routine treatment in Germany. These comments take the recommendations of the Breast Committee of the Gynecological Oncology Working Group (Arbeitsgemeinschaft Gynäkologische Onkologie; AGO) into account. The report and assessment presented here pertain to the preliminary results of the ABC5 consensus. The final version of the statements will be published in Annals of Oncology and The Breast.

The 5th International Consensus Conference for Advanced Breast Cancer (ABC5) took place on November 14–16, 2019, in Lisbon, Portugal. Its aim is to standardize the treatment of advanced breast cancer based on the available evidence and to ensure that all breast cancer patients worldwide receive adequate treatment and access to new therapies. This year, the conference focused on developments and study results in the treatment of patients with hormone receptor-positive/HER2-negative breast cancer as well as precision medicine. As in previous years, patient advocates from around the world were integrated into the ABC conference and had seats on the ABC consensus panel. In the present paper, a working group of German breast cancer experts comments on the results of the on-site ABC5 consensus votes by ABC panelists regarding their applicability for routine treatment in Germany. These comments take the recommendations of the Breast Committee of the Gynecological Oncology Working Group (Arbeitsgemeinschaft Gynäkologische Onkologie; AGO) into account. The report and assessment presented here pertain to the preliminary results of the ABC5 consensus. The final version of the statements will be published in Annals of Oncology and The Breast.

Ein dringlicher Appell an uns alle: Wenn wir unsere Städte und unser kulturelles Erbe weiterhin einem so rücksichtslosen Profitstreben ausliefern, werden sie untergehen – und wir mit ihnen. Venedig mit seiner einzigartigen Architektur, Geschichte und geographischen Lage, aber auch Venedig als Ausbund der Kommerzialisierung dieser Einzigartigkeit nimmt Salvatore Settis, der zum kulturellen Gewissen Italiens geworden ist, als Ausgangspunkt für grundsätzliche Überlegungen: Gibt es so etwas wie die Seele einer Stadt? Und worin genau bestünde diese? Vielleicht in ihrer Geschichte, ihren Einwohnern, ihrer Eigentümlichkeit? Warum gehören Wolkenkratzer zu New York, aber nicht nach Venedig? Sollte man die Schönheit einer Stadt als »Weltkulturerbe« konservieren, oder brauchen Städte eine »kreative Zerstörung«? Wie steht es mit dem »Recht auf Stadt«? Wie mit den Rechten künftiger Generationen? Venedig – ein emblematisches Beispiel für die Zukunft unserer Städte.Salvatore Settis wurde in Rosarno/Kalabrien geboren. Der Archäologe und Kunsthistoriker leitete von 1994 bis 1999 das Getty Research Institute for the History of Art in Los Angeles. Danach lehrte er an der Scuola Normale Superiore in Pisa Klassische Archäologie. Von 1999 bis 2010 war er Direktor dieser Universität. Lothar Müller, geboren in Dortmund, Kultur- und Literaturwissenschaftler, ist Redakteur im Feuilleton der Süddeutschen Zeitung und Honorarprofessor an der Humboldt-Universität zu Berlin. Für seine feuilletonistische Arbeit wurde er unter anderem mit dem Alfred-Kerr-Preis ausgezeichnet. Un appello urgente rivolto a tutti noi: se continuiamo ad approfittare in maniera così sconsiderata del nostro patrimonio culturale, le città sprofonderanno – e noi con loro. Salvatore Settis – ormai coscienza culturale dell’Italia – parte dall’unicità di Venezia, con le sue architetture, la sua storia e la sua geografia, passando per la Venezia apice della commercializzazione, come punto di partenza per una riflessione d, Salvatore Settis and Lothar Müller, Wenn Venedig stirbt: Über den Ausverkauf unserer Städte, discussion, ICI Berlin, 9 May 2016

Ein dringlicher Appell an uns alle: Wenn wir unsere Städte und unser kulturelles Erbe weiterhin einem so rücksichtslosen Profitstreben ausliefern, werden sie untergehen – und wir mit ihnen. Venedig mit seiner einzigartigen Architektur, Geschichte und geographischen Lage, aber auch Venedig als Ausbund der Kommerzialisierung dieser Einzigartigkeit nimmt Salvatore Settis, der zum kulturellen Gewissen Italiens geworden ist, als Ausgangspunkt für grundsätzliche Überlegungen: Gibt es so etwas wie die Seele einer Stadt? Und worin genau bestünde diese? Vielleicht in ihrer Geschichte, ihren Einwohnern, ihrer Eigentümlichkeit? Warum gehören Wolkenkratzer zu New York, aber nicht nach Venedig? Sollte man die Schönheit einer Stadt als »Weltkulturerbe« konservieren, oder brauchen Städte eine »kreative Zerstörung«? Wie steht es mit dem »Recht auf Stadt«? Wie mit den Rechten künftiger Generationen? Venedig – ein emblematisches Beispiel für die Zukunft unserer Städte.Salvatore Settis wurde in Rosarno/Kalabrien geboren. Der Archäologe und Kunsthistoriker leitete von 1994 bis 1999 das Getty Research Institute for the History of Art in Los Angeles. Danach lehrte er an der Scuola Normale Superiore in Pisa Klassische Archäologie. Von 1999 bis 2010 war er Direktor dieser Universität. Lothar Müller, geboren in Dortmund, Kultur- und Literaturwissenschaftler, ist Redakteur im Feuilleton der Süddeutschen Zeitung und Honorarprofessor an der Humboldt-Universität zu Berlin. Für seine feuilletonistische Arbeit wurde er unter anderem mit dem Alfred-Kerr-Preis ausgezeichnet. Un appello urgente rivolto a tutti noi: se continuiamo ad approfittare in maniera così sconsiderata del nostro patrimonio culturale, le città sprofonderanno – e noi con loro. Salvatore Settis – ormai coscienza culturale dell’Italia – parte dall’unicità di Venezia, con le sue architetture, la sua storia e la sua geografia, passando per la Venezia apice della commercializzazione, come punto di partenza per una riflessione d, Salvatore Settis and Lothar Müller, Wenn Venedig stirbt: Über den Ausverkauf unserer Städte, discussion, ICI Berlin, 9 May 2016

Purpose: The PELICAN trial evaluates for the first time efficacy and safety of pegylated liposomal doxorubicin (PLD) versus capecitabine as first-line treatment of metastatic breast cancer (MBC). Methods: This randomized, phase III, open-label, multicenter trial enrolled first-line MBC patients who were ineligible for endocrine or trastuzumab therapy. Cumulative adjuvant anthracyclines of 360 mg/m2 doxorubicin or equivalent were allowed. Left ventricular ejection fraction of >50 % was required. Patients received PLD 50 mg/m2 every 28 days or capecitabine 1250 mg/m2 twice daily for 14 days every 21 days. The primary endpoint was time-to-disease progression (TTP). Results: 210 patients were randomized (n = 105, PLD and n = 105, capecitabine). Adjuvant anthracyclines were given to 37 % (PLD) and 36 % (capecitabine) of patients. No significant difference was observed in TTP [HR = 1.21 (95 % confidence interval, 0.838–1.750)]. Median TTP was 6.0 months for both PLD and capecitabine. Comparing patients with or without prior anthracyclines, no significant difference in TTP was observed in the PLD arm (log-rank P = 0.64). For PLD versus capecitabine, respectively, overall survival (median, 23.3 months vs. 26.8 months) and time-to-treatment failure (median, 4.6 months vs. 3.7 months) were not statistically significantly different. Compared to PLD, patients on capecitabine experienced more serious adverse events (P = 0.015) and more cardiac events among patients who had prior anthracycline exposure (18 vs. 8 %; P = 0.31). Conclusion: Both PLD and capecitabine are effective first-line agents for MBC.