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Your search keyword '"Loeb, L A"' showing total 9 results
Start Over Author "Loeb, L A" Publication Type Electronic Resources
9 results on '"Loeb, L A"'

1. Newly exerted T cell pressures on mutated epitopes following transmission help maintain consensus HIV-1 sequences

Author

Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Eriksson, EM, Liegler, T, Keh, CE, Karlsson, AC, Holditch, SJ, Pilcher, CD, Loeb, L, Nixon, DF, Hecht, FM, Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Eriksson, EM, Liegler, T, Keh, CE, Karlsson, AC, Holditch, SJ, Pilcher, CD, Loeb, L, Nixon, DF, and Hecht, FM

Abstract

© 2015 Eriksson et al.CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV

Published
2015

2. Newly exerted T cell pressures on mutated epitopes following transmission help maintain consensus HIV-1 sequences

Author

Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Eriksson, EM, Liegler, T, Keh, CE, Karlsson, AC, Holditch, SJ, Pilcher, CD, Loeb, L, Nixon, DF, Hecht, FM, Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Eriksson, EM, Liegler, T, Keh, CE, Karlsson, AC, Holditch, SJ, Pilcher, CD, Loeb, L, Nixon, DF, and Hecht, FM

Abstract

© 2015 Eriksson et al.CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV

Published
2015

3. Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences.

Author

Paxton, WA, Eriksson, EM, Liegler, T, Keh, CE, Karlsson, AC, Holditch, SJ, Pilcher, CD, Loeb, L, Nixon, DF, Hecht, FM, Paxton, WA, Eriksson, EM, Liegler, T, Keh, CE, Karlsson, AC, Holditch, SJ, Pilcher, CD, Loeb, L, Nixon, DF, and Hecht, FM

Abstract

CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV-1 infection, less is known about the importance of T cell pressure in reversing HIV-1 virus back to a consensus sequences. In this study we aimed to assess the frequency with which reversion of transmitted mutations in T cell epitopes were associated with T cell responses to the mutation. This study included 14 HIV-1 transmission pairs consisting of a 'source' (virus-donor) and a 'recipient' (newly infected individual). Non-consensus B sequence amino acids (mutations) in T cell epitopes in HIV-1 gag regions p17, p24, p2 and p7 were identified in each pair and transmission of mutations to the recipient was verified with population viral sequencing. Longitudinal analyses of the recipient's viral sequence were used to identify whether reversion of mutations back to the consensus B sequence occurred. Autologous 12-mer peptides overlapping by 11 were synthesized, representing the sequence region surrounding each reversion and longitudinal analysis of T cell responses to source-derived mutated and reverted epitopes were assessed. We demonstrated that mutations in the source were frequently transmitted to the new host and on an average 17 percent of mutated epitopes reverted to consensus sequence in the recipient. T cell responses to these mutated epitopes were detected in 7 of the 14 recipients in whom reversion occurred. Overall, these findings indicate that transmitted non-consensus B epitopes are frequently immunogenic in HLA-mismatched recipients and new T cell pressures to T cell escape mutations following transmission play a significant role in maintaining consensus HIV-1 sequences.

Published
2014

4. Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men

Author

Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Grant, Robert, Vallabhaneni, S, McConnell, JJ, Loeb, L, Hartogensis, W, Hecht, FM, Grant, RM, Pilcher, CD, Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Grant, Robert, Vallabhaneni, S, McConnell, JJ, Loeb, L, Hartogensis, W, Hecht, FM, Grant, RM, and Pilcher, CD

Abstract

Objective: We assessed changes in sexual behavior among men who have sex with men (MSM), before and for several years after HIV diagnosis, accounting for adoption of a variety of seroadaptive practices. Methods: We collected self-reported sexual behavior d

Published
2013

5. Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men

Author

Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Grant, Robert, Vallabhaneni, S, McConnell, JJ, Loeb, L, Hartogensis, W, Hecht, FM, Grant, RM, Pilcher, CD, Hecht, Frederick, Hecht, Frederick, Pilcher, Christopher, Grant, Robert, Vallabhaneni, S, McConnell, JJ, Loeb, L, Hartogensis, W, Hecht, FM, Grant, RM, and Pilcher, CD

Abstract

Objective: We assessed changes in sexual behavior among men who have sex with men (MSM), before and for several years after HIV diagnosis, accounting for adoption of a variety of seroadaptive practices. Methods: We collected self-reported sexual behavior d

Published
2013

8. Lettres du marquis A. de Custine à Varnhagen d'Ense et Rahel Varnhagen d'Ense : accompagnées de plusieurs lettres de la comtesse Delphine de Custine et de Rahel Varnhagen d'Ense / [publié par Ludmilla Assing]

Author

Custine, Delphine de Sabran (1770-1826 ; marquise de). Auteur de lettres, Varnhagen von Ense, Karl August (1785-1858). Auteur de lettres, Varnhagen von Ense, Rahel (1771-1833). Auteur de lettres, Assing-Grimelli, Ludmilla (18..-1880). Éditeur scientifique, Loeb, L. (Dr). Traducteur, Custine, Astolphe de (1790-1857). Auteur du texte, Custine, Delphine de Sabran (1770-1826 ; marquise de). Auteur de lettres, Varnhagen von Ense, Karl August (1785-1858). Auteur de lettres, Varnhagen von Ense, Rahel (1771-1833). Auteur de lettres, Assing-Grimelli, Ludmilla (18..-1880). Éditeur scientifique, Loeb, L. (Dr). Traducteur, and Custine, Astolphe de (1790-1857). Auteur du texte

Abstract

Avec mode texte

9. Lettres du marquis A. de Custine à Varnhagen d'Ense et Rahel Varnhagen d'Ense : accompagnées de plusieurs lettres de la comtesse Delphine de Custine et de Rahel Varnhagen d'Ense / [publié par Ludmilla Assing]

Author

Custine, Delphine de Sabran (1770-1826 ; marquise de). Auteur de lettres, Varnhagen von Ense, Karl August (1785-1858). Auteur de lettres, Varnhagen von Ense, Rahel (1771-1833). Auteur de lettres, Assing-Grimelli, Ludmilla (18..-1880). Éditeur scientifique, Loeb, L. (Dr). Traducteur, Custine, Astolphe de (1790-1857). Auteur du texte, Custine, Delphine de Sabran (1770-1826 ; marquise de). Auteur de lettres, Varnhagen von Ense, Karl August (1785-1858). Auteur de lettres, Varnhagen von Ense, Rahel (1771-1833). Auteur de lettres, Assing-Grimelli, Ludmilla (18..-1880). Éditeur scientifique, Loeb, L. (Dr). Traducteur, and Custine, Astolphe de (1790-1857). Auteur du texte

Abstract

Avec mode texte

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