Search

Your search keyword '"Leroux, Agnes"' showing total 6 results
Start Over Author "Leroux, Agnes" Publication Type Electronic Resources
6 results on '"Leroux, Agnes"'

1. Sentinel Node in Oral Cancer: The Nuclear Medicine Aspects. A Survey from the Sentinel European Node Trial.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi, Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amezaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutierrez, Luis Manuel, Barbier, Luis, Santamaria-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cécile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, McGurk, Mark, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi, Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amezaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutierrez, Luis Manuel, Barbier, Luis, Santamaria-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cécile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, and McGurk, Mark

Abstract

PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed. METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy. According to institutional protocols, all patients underwent preoperative dynamic/static scan and/or SPECT/CT. RESULTS: Lymphoscintigraphy identified 723 lymphatic basins. 1398 sentinel lymph nodes (SNs) were biopsied (3.2 SN per patient; range, 1-10). Dynamic scan allowed the differentiation of sentinel nodes from second tier lymph nodes. SPECT/CT allowed more accurate anatomical localization and estimated SN depth more efficiently. After pathological examination, 9.9% of the SN excised (138 of 1398 SNs) showed metastases. The first neck level (NL) containing SN+ was NL I in 28.6%, NL IIa in 44.8%, NL IIb in 2.8%, NL III in 17.1%, and NL IV in 6.7% of positive patients. Approximately 96% of positive SNs were localized in the first and second lymphatic basin visualized using lymphoscintigraphy. After neck dissection, the SN+ was the only lymph node containing metastasis in approximately 80% of patients. CONCLUSIONS: Best results were observed using a dynamic scan in combination with SPECT/CT. A shorter interval between tracer injection, imaging, and surgery resulted in a lower false-negative rate. At least 2 NLs have to be harvested, as this may increase the detection of lymphatic metastases.

Published
2016

2. Sentinel Node in Oral Cancer:The Nuclear Medicine Aspects. A Survey from the Sentinel European Node Trial

Author

Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi T., Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amézaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael J, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin A S, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutiérrez, Luis Manuel, Barbier Herrero, Luis, Santamaría-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cecile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, McGurk, Mark, Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi T., Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amézaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael J, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin A S, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutiérrez, Luis Manuel, Barbier Herrero, Luis, Santamaría-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cecile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, and McGurk, Mark

Abstract

PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed.METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy. According to institutional protocols, all patients underwent preoperative dynamic/static scan and/or SPECT/CT.RESULTS: Lymphoscintigraphy identified 723 lymphatic basins. 1398 sentinel lymph nodes (SNs) were biopsied (3.2 SN per patient; range, 1-10). Dynamic scan allowed the differentiation of sentinel nodes from second tier lymph nodes. SPECT/CT allowed more accurate anatomical localization and estimated SN depth more efficiently. After pathological examination, 9.9% of the SN excised (138 of 1398 SNs) showed metastases. The first neck level (NL) containing SN+ was NL I in 28.6%, NL IIa in 44.8%, NL IIb in 2.8%, NL III in 17.1%, and NL IV in 6.7% of positive patients. Approximately 96% of positive SNs were localized in the first and second lymphatic basin visualized using lymphoscintigraphy. After neck dissection, the SN+ was the only lymph node containing metastasis in approximately 80% of patients.CONCLUSIONS: Best results were observed using a dynamic scan in combination with SPECT/CT. A shorter interval between tracer injection, imaging, and surgery resulted in a lower false-negative rate. At least 2 NLs have to be harvested, as this may increase the detection of lymphatic metastases.

Published
2016

3. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer.

Author

UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cécile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, McGurk, Mark, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cécile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, and McGurk, Mark

Abstract

PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma. METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up. RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%. CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.

Published
2015

4. Sentinel European Node Trial (SENT):3-year results of sentinel node biopsy in oral cancer

Author

Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cecile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, McGurk, Mark, Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cecile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, and McGurk, Mark

Abstract

PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.

Published
2015

5. Implications of a positive sentinel node in oral squamous cell carcinoma

Author

Gurney, Benjamin A S, Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W, Alvarez, Amezaga J, Bakholdt, Vivi T., Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Dalla Palma, Paolo, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B, Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F, Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H, Mamelle, Gerard, Silini, Enrico M, Mastronicola, Romina, Odell, Edward W, O'Doherty, Michael J, Poli, Tito, Rahimi, Siavash, Ross, Gary L, Zuazua, J Santamaria, Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S, Therkildsen, Marianne H, Vigili, Maurizio Giovanni, Villarreal, Pedro M, von Buchwald, Christian, Werner, Jochen A, Wiegand, Susanne, McGurk, Mark, Gurney, Benjamin A S, Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W, Alvarez, Amezaga J, Bakholdt, Vivi T., Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Dalla Palma, Paolo, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B, Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F, Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H, Mamelle, Gerard, Silini, Enrico M, Mastronicola, Romina, Odell, Edward W, O'Doherty, Michael J, Poli, Tito, Rahimi, Siavash, Ross, Gary L, Zuazua, J Santamaria, Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S, Therkildsen, Marianne H, Vigili, Maurizio Giovanni, Villarreal, Pedro M, von Buchwald, Christian, Werner, Jochen A, Wiegand, Susanne, and McGurk, Mark

Abstract

The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

Published
2012

6. Implications of a positive sentinel node in oral squamous cell carcinoma

Author

Gurney, Benjamin A S, Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W, Alvarez, Amezaga J, Bakholdt, Vivi T., Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Dalla Palma, Paolo, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B, Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F, Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H, Mamelle, Gerard, Silini, Enrico M, Mastronicola, Romina, Odell, Edward W, O'Doherty, Michael J, Poli, Tito, Rahimi, Siavash, Ross, Gary L, Zuazua, J Santamaria, Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S, Therkildsen, Marianne H, Vigili, Maurizio Giovanni, Villarreal, Pedro M, von Buchwald, Christian, Werner, Jochen A, Wiegand, Susanne, McGurk, Mark, Gurney, Benjamin A S, Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W, Alvarez, Amezaga J, Bakholdt, Vivi T., Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Dalla Palma, Paolo, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B, Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F, Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H, Mamelle, Gerard, Silini, Enrico M, Mastronicola, Romina, Odell, Edward W, O'Doherty, Michael J, Poli, Tito, Rahimi, Siavash, Ross, Gary L, Zuazua, J Santamaria, Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S, Therkildsen, Marianne H, Vigili, Maurizio Giovanni, Villarreal, Pedro M, von Buchwald, Christian, Werner, Jochen A, Wiegand, Susanne, and McGurk, Mark

Abstract

The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results