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Your search keyword '"Lein, E"' showing total 12 results
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12 results on '"Lein, E"'

1. Building a high-quality Human Cell Atlas

Author

Rozenblatt-Rosen, O., Shin, J. W., Rood, J. E., Hupalowska, A., Ardlie, K., Clatworthy, M., Carninci, P., Enard, W., Greenleaf, W., Heyn, H., Lein, E., Levin, J. Z., Linnarsson, S., Lundberg, Emma, Meyer, K., Navin, N., Nolan, G., Teichmann, S., Voet, T., Zhuang, X., Regev, A., Group, Human Cell Atlas Standards and Technology Working, Rozenblatt-Rosen, O., Shin, J. W., Rood, J. E., Hupalowska, A., Ardlie, K., Clatworthy, M., Carninci, P., Enard, W., Greenleaf, W., Heyn, H., Lein, E., Levin, J. Z., Linnarsson, S., Lundberg, Emma, Meyer, K., Navin, N., Nolan, G., Teichmann, S., Voet, T., Zhuang, X., Regev, A., and Group, Human Cell Atlas Standards and Technology Working

Abstract

QC 20211116

Published
2021
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2. Italy

Author

Álvarez-Armas, E., Bineva, V., Cuniberti, G., Ebers, M., Fairgrieve, D., Fejős, A., Franzina, P., Gauci, J.-P., Hellner, M., Kačevska, I., Kinsler, M.L., Kramberger, J., Kramer, X., Lehmann, M., Palevičienė, S., Paukneróva, M., Pertegás Sender, M., Pfeiffer, M., Phelps, B., Poesen, M., Poretti, P., Rokas, K., Tornberg, L., Torralba, E., Trantea, G., Vale e Reis, R., Zamorska, M., Lein, E., Migliorini, S., Bonzé, C., O’Keeffe, S., Franzina, Pietro, Franzina, P. (ORCID:0000-0001-9601-2281), Álvarez-Armas, E., Bineva, V., Cuniberti, G., Ebers, M., Fairgrieve, D., Fejős, A., Franzina, P., Gauci, J.-P., Hellner, M., Kačevska, I., Kinsler, M.L., Kramberger, J., Kramer, X., Lehmann, M., Palevičienė, S., Paukneróva, M., Pertegás Sender, M., Pfeiffer, M., Phelps, B., Poesen, M., Poretti, P., Rokas, K., Tornberg, L., Torralba, E., Trantea, G., Vale e Reis, R., Zamorska, M., Lein, E., Migliorini, S., Bonzé, C., O’Keeffe, S., Franzina, Pietro, and Franzina, P. (ORCID:0000-0001-9601-2281)

Abstract

1. Introduction. - 2. Analysis of the Rome II Regulation. - 3. Comments on areas of interest.

Published
2021

4. Trans-life cycle acclimation to experimental ocean acidification affects gastric pH homeostasis and larval recruitment in the sea star Asterias rubens

Author

Hu, Marian Yong-An, Lein, E, Bleich, Markus, Melzner, Frank, Stumpp, Meike, Hu, Marian Yong-An, Lein, E, Bleich, Markus, Melzner, Frank, and Stumpp, Meike

Abstract

Aim: Experimental simulation of near‐future ocean acidification (OA) has been demonstrated to affect growth and development of echinoderm larval stages through energy allocation towards ion and pH compensatory processes. To date, it remains largely unknown how major pH regulatory systems and their energetics are affected by trans‐generational exposure to near‐future acidification levels. Methods: Here, we used the common sea star Asterias rubens in a reciprocal transplant experiment comprising different combinations of OA scenarios, to study trans‐generational plasticity using morphological and physiological endpoints. Results: Acclimation of adults to pHT 7.2 (pCO2 3500 μatm) led to reductions in feeding rates, gonad weight and fecundity. No effects were evident at moderate acidification levels (pHT 7.4; pCO2 2000 μatm). Parental pre‐acclimation to pHT 7.2 for 85 days reduced developmental rates even when larvae were raised under moderate and high pH conditions, whereas pre‐acclimation to pHT 7.4 did not alter offspring performance. Microelectrode measurements and pharmacological inhibitor studies carried out on larval stages demonstrated that maintenance of alkaline gastric pH represents a substantial energy sink under acidified conditions that may contribute up to 30% to the total energy budget. Conclusion: Parental pre‐acclimation to acidification levels that are beyond the pH that is encountered by this population in its natural habitat (eg, pHT 7.2) negatively affected larval size and development, potentially through reduced energy transfer. Maintenance of alkaline gastric pH and reductions in maternal energy reserves probably constitute the main factors for a reduced juvenile recruitment of this marine keystone species under simulated OA.

Published
2018

5. Collective redress in Europe - Why and How?

Author

Lein, E., Fairgrieve, D., Crespo, M. O., Smith, V., Barker, George, Freyens, Benoit, Lein, E., Fairgrieve, D., Crespo, M. O., Smith, V., Barker, George, and Freyens, Benoit

Abstract

The European Commission Recommendation on Collective Redress (2013/396/EU) establishes a framework to ensure a coherent horizontal approach to collective litigation in the EU context without harmonising national systems. The Commission clearly aims at distinguishing collective redress in Europe from the North American class action approach.

Published
2015

6. Article 37

Author

Dickinson, A., Lein, E., Franzina, Pietro, Franzina, P. (ORCID:0000-0001-9601-2281), Dickinson, A., Lein, E., Franzina, Pietro, and Franzina, P. (ORCID:0000-0001-9601-2281)

Abstract

A. Introduction and legislative history. - B. ‘Invoking’ a judgment. - C. The requirements relevant to recognition distinguished from those relevant to enforcement. - D. The required documents. - E. Translation and transliteration of the certificate and the judgment. - F. The exclusive nature of the Art 37 requirements.

Published
2015

7. Article 38

Author

Dickinson, A., Lein, E., Franzina, Pietro, Franzina, P. (ORCID:0000-0001-9601-2281), Dickinson, A., Lein, E., Franzina, Pietro, and Franzina, P. (ORCID:0000-0001-9601-2281)

Abstract

A. Introduction and legislative history. - B. The rationale of the rule. - C. Stay of proceedings where the judgment has been challenged. - D. Stay of proceedings where an application for a decision on recognition has been made.

Published
2015

8. Article 36

Author

Dickinson, A., Lein, E., Franzina, Pietro, Franzina, P. (ORCID:0000-0001-9601-2281), Dickinson, A., Lein, E., Franzina, Pietro, and Franzina, P. (ORCID:0000-0001-9601-2281)

Abstract

1. Introduction and legislative history. - 2. The concept of ‘recognition’ (Art 36(1)). - A. Recognition distinguished from enforceability. - B. Evidentiary and factual effects of judgments. - C. Partial recognition. - D. The automatic character of recognition. - E. Automatic recognition as a cornerstone of the Brussels I regime. - 3. The scope of a judgment’s authority and effectiveness. - A. The effects of judgments under national law. - B. The law applicable to the effectiveness of a judgment: the doctrine of extension. - C. The doctrine of extension in practice. - D. Effects to be determined under a law other than the law of the state of origin. - E. Criticisms of the doctrine of extension. - F. The emergence of competing doctrines. - 4. Self-standing declaratory proceedings (Art 36(2)). - A. The relief sought. - B. Situations where an interest may exist for bringing declaratory proceedings. - C. The object of declaratory proceedings. - D. The issue of jurisdiction and the effect of res judicata on decisions under Art 36(2). - E. Procedural issues. - 5. Recognition as an incidental question (Art 36(3)). - A. The relationship between the incidental and the main issues. - B. Incidental issues falling outside the scope of the Regulation. - C. The object of determinations made in respect of an incidental question. - D. Procedural issues. - E. The res judicata effect of judgments in dependent proceedings.

Published
2015

9. Disruptive CHD8 mutations define a subtype of autism early in development.

Author

Bernier, R., Golzio, C., Xiong, B., Stessman, H.A., Coe, B.P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Silfhout, A.T. van, Schuurs-Hoeijmakers, J.H.M., Fichera, M., Bosco, P., Buono, S., Alberti, A., Failla, P., Peeters, H., Steyaert, J., Vissers, L.E.L.M., Francescatto, L., Mefford, H.C., Rosenfeld, J.A., Bakken, T., O'Roak, B.J., Pawlus, M., Moon, R., Shendure, J., Amaral, D.G., Lein, E., Rankin, J., Romano, C, Vries, L.B.A. de, Katsanis, N., Eichler, E.E., Bernier, R., Golzio, C., Xiong, B., Stessman, H.A., Coe, B.P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Silfhout, A.T. van, Schuurs-Hoeijmakers, J.H.M., Fichera, M., Bosco, P., Buono, S., Alberti, A., Failla, P., Peeters, H., Steyaert, J., Vissers, L.E.L.M., Francescatto, L., Mefford, H.C., Rosenfeld, J.A., Bakken, T., O'Roak, B.J., Pawlus, M., Moon, R., Shendure, J., Amaral, D.G., Lein, E., Rankin, J., Romano, C, Vries, L.B.A. de, Katsanis, N., and Eichler, E.E.

Abstract

Item does not contain fulltext

Published
2014

10. Disruptive CHD8 mutations define a subtype of autism early in development.

Author

Bernier, R., Golzio, C., Xiong, B., Stessman, H.A., Coe, B.P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Silfhout, A.T. van, Schuurs-Hoeijmakers, J.H.M., Fichera, M., Bosco, P., Buono, S., Alberti, A., Failla, P., Peeters, H., Steyaert, J., Vissers, L.E.L.M., Francescatto, L., Mefford, H.C., Rosenfeld, J.A., Bakken, T., O'Roak, B.J., Pawlus, M., Moon, R., Shendure, J., Amaral, D.G., Lein, E., Rankin, J., Romano, C, Vries, L.B.A. de, Katsanis, N., Eichler, E.E., Bernier, R., Golzio, C., Xiong, B., Stessman, H.A., Coe, B.P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Silfhout, A.T. van, Schuurs-Hoeijmakers, J.H.M., Fichera, M., Bosco, P., Buono, S., Alberti, A., Failla, P., Peeters, H., Steyaert, J., Vissers, L.E.L.M., Francescatto, L., Mefford, H.C., Rosenfeld, J.A., Bakken, T., O'Roak, B.J., Pawlus, M., Moon, R., Shendure, J., Amaral, D.G., Lein, E., Rankin, J., Romano, C, Vries, L.B.A. de, Katsanis, N., and Eichler, E.E.

Abstract

Item does not contain fulltext

Published
2014

11. Convergent transcriptional specializations in the brains of humans and song-learning birds

Author

Pfenning, A., Hara, E., Whitney, O., Rivas, M., Wang, R., Roulhac, P., Howard, J., Wirthlin, M., Lovell, P., Ganapathy, G., Mouncastle, J., Moseley, M.A., Thompson, J W., Soderblom, E.j, Iriki, A., Kato, M., Gilbert, Thomas, Zhang, G., Bakken, T., Bongaarts, A., Bernard, A., Lein, E., Mello, C., Hartemink, A., Jarvis, E., Pfenning, A., Hara, E., Whitney, O., Rivas, M., Wang, R., Roulhac, P., Howard, J., Wirthlin, M., Lovell, P., Ganapathy, G., Mouncastle, J., Moseley, M.A., Thompson, J W., Soderblom, E.j, Iriki, A., Kato, M., Gilbert, Thomas, Zhang, G., Bakken, T., Bongaarts, A., Bernard, A., Lein, E., Mello, C., Hartemink, A., and Jarvis, E.

Abstract

Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.

Published
2014

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