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Broomrape (Orobanche cumana) is a continuous threat to sunflower production. Awidely used method to control this parasitic plant is the development of resistant hybrids. The control method itself requires knowledge of parasite virulence present in the particular region. Virulence determination is based on the reaction of differential sunflower genotypes and several genotypes are in use by researchers to determine broomrape race labeled with capital Latin letters. In Serbia, broomrape is present in some sunflower planting regions. Recently, researched limited number of broomrape populations indicated a sparse presence of race F. In this research over 200 sunflower fields were surveyed for the presence of the parasites. Broomrape plants were collected, air dried and labeled. Parasite virulence was determined using inbred lines AD-66, LC1002, LC1003, LC1093, NR5, and P96, to identify race type based on the reaction of sunflower to broomrape. Experiments were conducted in semi- controlled greenhouse conditions by growing differential lines in pots containing substrate with broomrape seeds. Reaction of each line was determined based on broomrape presence on the host root. Broomrape was found in 88 sunflower fields. In majority of surveyed fields, parasite was found sparsely ranging from few individuals to small patches of infested sunflower plants. Results have confirmed the presence of race F based on the susceptibility of line NR5 and the presence of race G based on the susceptibility of line P96. Further research will include increased number of genotypes to assess variability in broomrape virulence and experiments for genetic diversity determination of parasitic populations of various geographical origin.

Dezhi Yang,1,* Jing Lan,2,* Ji Cen,3,* Yong Han,4– 6 Haofei Hu6– 8 1Department of Cardiology Second Ward, Hechi People’s Hospital, Hechi, People’s Republic of China; 2Department of Gastroenterology, Hechi People’s Hospital, Hechi, People’s Republic of China; 3Department of Nephrology, Hechi People’s Hospital, Hechi, People’s Republic of China; 4Department of Emergency, Shenzhen Second People’s Hospital, Shenzhen, People’s Republic of China; 5Department of Emergency, The First Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 6Shenzhen University Health Science Center, Shenzhen University, Shenzhen, People’s Republic of China; 7Department of Nephrology, Shenzhen Second People’s Hospital, Shenzhen, People’s Republic of China; 8Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Han, Department of Emergency, Shenzhen Second People’s Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, Guangdong Province, People’s Republic of China, Tel +86-755-83366388, Email hanyong511023@163.com Haofei Hu, Department of Nephrology, Shenzhen Second People’s Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, Guangdong Province, People’s Republic of China, Tel +86-755-83366388, Email huhaofei0319@126.comBackground: Quantification of the relationship between hypertension and non-alcoholic fatty liver disease (NAFLD) risk is limited and controversial. This study aimed to investigate the relationship between hypertension and NAFLD in non-obese Chinese and to use different methods to demonstrate that hypertension is an independent risk factor for NAFLD.Methods: On 16,153 nonobese individuals, a retrospective cohort study was conducted in China to examine the impact of hypertension on incident NAFLD. We compared five methods: multivariable Cox pr

11 april 2022, Contains fulltext : 284680.pdf (Publisher’s version ) (Closed access)

11 april 2022, Contains fulltext : 284680.pdf (Publisher’s version ) (Closed access)

The competitive removal of Pb2+ and malachite green (MG) from water by three magnetic phosphate nanocomposites (Fe3O4/Ba3(PO4)2, Fe3O4/Sr5(PO4)3(OH), and Fe3O4/Sr5xBa3x(PO4)3(OH), namely "FBP", "FSP", and "FSBP", respectively) was systematically investigated compared with Fe3O4 ("F") nanoparticle. Temperature and adsorbent dosage for competitive removal were optimized to be 20 °C and 0.05 g in 50 mL. The kinetic and isothermal adsorption results were fitted well with the pseudo-second-order model and Langmuir model, respectively. In the competitive removal process, FSP showed a high affinity to Pb2+ (202.8 mg/g) while FBP possessed high selectivity for MG (175.4 mg/g), and FSBP was effective at simultaneous removal of Pb2+ and MG, with a capacity of 143.7 and 90.9 mg/g, respectively. The magnetic contents in nanocomposites allow magnetic separation of materials from the water after treatment. We proposed that the simultaneous removal mechanism by FSBP was due to ion exchange between Pb2+ and Sr2+ in the lattice and then the formation of hydrogen bonds between PO43- outside the material's surface and positively charged hydrogen in MG. This study indicates the potential of these phosphate nanocomposites to be used as effective materials for selective or simultaneous removal of Pb2+ and MG from water.

The competitive removal of Pb2+ and malachite green (MG) from water by three magnetic phosphate nanocomposites (Fe3O4/Ba3(PO4)2, Fe3O4/Sr5(PO4)3(OH), and Fe3O4/Sr5xBa3x(PO4)3(OH), namely "FBP", "FSP", and "FSBP", respectively) was systematically investigated compared with Fe3O4 ("F") nanoparticle. Temperature and adsorbent dosage for competitive removal were optimized to be 20 °C and 0.05 g in 50 mL. The kinetic and isothermal adsorption results were fitted well with the pseudo-second-order model and Langmuir model, respectively. In the competitive removal process, FSP showed a high affinity to Pb2+ (202.8 mg/g) while FBP possessed high selectivity for MG (175.4 mg/g), and FSBP was effective at simultaneous removal of Pb2+ and MG, with a capacity of 143.7 and 90.9 mg/g, respectively. The magnetic contents in nanocomposites allow magnetic separation of materials from the water after treatment. We proposed that the simultaneous removal mechanism by FSBP was due to ion exchange between Pb2+ and Sr2+ in the lattice and then the formation of hydrogen bonds between PO43- outside the material's surface and positively charged hydrogen in MG. This study indicates the potential of these phosphate nanocomposites to be used as effective materials for selective or simultaneous removal of Pb2+ and MG from water.

Through addressing the motivations behind rural households’ livelihood diversification, this paper examines the effect of the Sloping Land Conversion Program (SLCP) on livelihood diversification using a longitudinal household survey data set spanning the overall implementation of the SLCP. Our results show that the SLCP works as a valid external policy intervention to increase rural livelihood diversification. In addition, the findings demonstrate that the implementation of the SLCP has had heterogeneous effects on livelihood diversification across different rural income groups. The lower income group was more affected by the program in terms of income diversification., Through addressing the motivations behind rural households’ livelihood diversification, this paper examines the effect of the Sloping Land Conversion Program (SLCP) on livelihood diversification using a longitudinal household survey data set spanning the overall implementation of the SLCP. Our results show that the SLCP works as a valid external policy intervention to increase rural livelihood diversification. In addition, the findings demonstrate that the implementation of the SLCP has had heterogeneous effects on livelihood diversification across different rural income groups. The lower income group was more affected by the program in terms of income diversification.

Multiple proxies of terrestrial organic matters (TOM) were introduced to study the migration behaviors of short-chain chlorinated paraffins (SCCPs) in the coastal East China Sea (ECS). The contents of SCCPs in the surface sediment collected from Changjiang (Yangtze) River Delta (CRD) and along the Zhejiang-Fujian coastline ranged from 9.0 to 37.2 ng/g (dry weight, d.w.), displaying a "band-style" distribution trend. Spatial distribution patterns of SCCP congeners presented an increasing trend seaward and southward along the coastline for shorter carbon length (C₁₀ + C₁₁) and lower chlorinated (Cl₅ + Cl₆ + Cl₇) congeners, suggesting a spreading tendency seaward and southward from the CRD and the north of the inner shelf. The significant relationship between ΣSCCPs and total organic carbons (TOC) (r(2) = 0.402, p < 0.05) indicated that the migration of SCCPs in sediments was markedly affected by TOC. The spatial patterns of the TOM proxies of TOC δ(13)C, the contents of ΣC₂₇ + C₂₉ + C₃₁ n-alkanes, terrestrial marine biomarker ratio (TMBR), and terrestrial TOC (T-TOC) were all similar to that of ΣSCCPs. Linear relationships between SCCP contents and both the contents of ΣC₂₇ + C₂₉ + C₃₁ n-alkanes (r(2) = 0.537, p < 0.05) and T-TOC (r(2) = 0.495, p < 0.05) were also observed. The consistence demonstrated that a major portion of sedimentary SCCPs in the coastal ECS should be from the river input of Changjiang River and deposited in the CRD and along the inner shelf of the ECS, but only a minor fraction was transported to the offshore areas., Sponsors:National Natural Science Foundation Grant no:s 21007062 21007078 41020164005 SKLECE Open Fund KF2009-21 Young Teachers Special Fund Ocean University of China Grant no: 201013018 SOA Open Fund Grant no: MESE-2011-07

Cdc25 protein phosphatases are regulators of cyclin-dependent kinases and are often highly expressed in human malignancies. Few small molecule inhibitors of the Cdc25 phosphatase family have been identified and little is known about their disposition, metabolism or efficacy in xenograft models. In this study, the efficacy, pharmacokinetics, and metabolism of a potent quinolinedione Cdc25 phosphatase inhibitor, DA3003-1, in mice was examined. DA3003-1 inhibited the growth of subcutaneous human colon HT29 xenografts in SCID mice. After a single i.v. dose of 5 mg/kg, DA3003-1 was not detectable in plasma or tissues beyond 5 min. In vitro studies showed that DA3003-1 was rapidly dechlorinated and conjugated to glutathione. Following DA3003-1 treatment of tumor-bearing SCID mice, reduced glutathione concentrations in HT29 tumor were decreased to a greater extent and remained decreased for longer than the reduced glutathione concentrations in liver and kidneys. These studies suggest that the minimal antitumor activity of DA3003-1 in mice may be due to its rapid metabolism.

Cdc25 protein phosphatases are regulators of cyclin-dependent kinases and are often highly expressed in human malignancies. Few small molecule inhibitors of the Cdc25 phosphatase family have been identified and little is known about their disposition, metabolism or efficacy in xenograft models. In this study, the efficacy, pharmacokinetics, and metabolism of a potent quinolinedione Cdc25 phosphatase inhibitor, DA3003-1, in mice was examined. DA3003-1 inhibited the growth of subcutaneous human colon HT29 xenografts in SCID mice. After a single i.v. dose of 5 mg/kg, DA3003-1 was not detectable in plasma or tissues beyond 5 min. In vitro studies showed that DA3003-1 was rapidly dechlorinated and conjugated to glutathione. Following DA3003-1 treatment of tumor-bearing SCID mice, reduced glutathione concentrations in HT29 tumor were decreased to a greater extent and remained decreased for longer than the reduced glutathione concentrations in liver and kidneys. These studies suggest that the minimal antitumor activity of DA3003-1 in mice may be due to its rapid metabolism.