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1. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Author

Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, Torrecilhas, Ana Claudia, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, and Torrecilhas, Ana Claudia

Abstract

In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in infections caused by viruses, bacteria, fungi, protozoa, and helminths based on the talks and discussions carried out during the International Society for Extracellular Vesicles (ISEV) workshop held in São Paulo (November, 2016), Brazil, entitled Cross-organism Communication by Extracellular Vesicles: Hosts, Microbes and Parasites.

Published
2017

2. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Author

LS Celbiologie-Algemeen, dB&C I&I, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, Torrecilhas, Ana Claudia, LS Celbiologie-Algemeen, dB&C I&I, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, and Torrecilhas, Ana Claudia

Published
2017

3. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Author

LS Celbiologie-Algemeen, dB&C I&I, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, Torrecilhas, Ana Claudia, LS Celbiologie-Algemeen, dB&C I&I, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, and Torrecilhas, Ana Claudia

Published
2017

4. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Author

LS Celbiologie-Algemeen, dB&C I&I, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, Torrecilhas, Ana Claudia, LS Celbiologie-Algemeen, dB&C I&I, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, and Torrecilhas, Ana Claudia

Published
2017

5. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Author

Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, Torrecilhas, Ana Claudia, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, and Torrecilhas, Ana Claudia

Abstract

In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in infections caused by viruses, bacteria, fungi, protozoa, and helminths based on the talks and discussions carried out during the International Society for Extracellular Vesicles (ISEV) workshop held in São Paulo (November, 2016), Brazil, entitled Cross-organism Communication by Extracellular Vesicles: Hosts, Microbes and Parasites.

Published
2017

6. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Author

Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, Torrecilhas, Ana Claudia, Soares, Rodrigo P., Xander, Patrícia, Costa, Adriana Oliveira, Marcilla, Antonio, Menezes-Neto, Armando, Del Portillo, Hernando, Witwer, Kenneth, Wauben, Marca, Nolte-T Hoen, Esther, Olivier, Martin, Criado, Miriã Ferreira, da Silva, Luis Lamberti P., Abdel Baqui, Munira Muhammad, Schenkman, Sergio, Colli, Walter, Alves, Maria Julia Manso, Ferreira, Karen Spadari, Puccia, Rosana, Nejsum, Peter, Riesbeck, Kristian, Stensballe, Allan, Hansen, Eline Palm, Jaular, Lorena Martin, Øvstebø, Reidun, de la Canal, Laura, Bergese, Paolo, Pereira-Chioccola, Vera, Pfaffl, Michael W., Fritz, Joëlle, Gho, Yong Song, and Torrecilhas, Ana Claudia

Abstract

In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role of EVs in infections caused by viruses, bacteria, fungi, protozoa, and helminths based on the talks and discussions carried out during the International Society for Extracellular Vesicles (ISEV) workshop held in São Paulo (November, 2016), Brazil, entitled Cross-organism Communication by Extracellular Vesicles: Hosts, Microbes and Parasites.

Published
2017

7. Early DEtection of wEaring off in Parkinson disease: the DEEP study

Author

Stocchi, Fabrizio, Antonini, Angelo, Barone, Paolo, Tinazzi, Michele, Zappia, Maria, Onofrj, Marco, Ruggieri, Stefano, Morgante, Letterio, Bonuccelli, Ubaldo, Lopiano, Leonardo, Pramstaller, Peter, Albanese, Alberto, Attar, Mahmood, Posocco, V, Colombo, D, Abbruzzese, Giovanni, Stocchi, F, Vacca, L, Pramstaller, Pp, Facheris, M, Guidotti, M, Mario, E, Riboldazzi, G, Leva, S, Priori, A, Pezzoli, G, Margherita, C, Soliveri, P, Picco, D, Pisano, F, Scarzella, L, Tavella, A, Zibetti, M, Ottaviani, S, Valzania, F, Contarsi, S, Quatrale, R, Sensi, M, Ceravolo, R, Rossi, C, Cincotta, M, Vanni, P, Del Dotto, P, Ceravolo, Mg, Capecci, M, Marchese, R, Tamburini, T, Thomas, A, Borelli, I, Marconi, R, Grasso, L, Stanzione, P, Pisani, V, Bentivoglio, Anna Rita, Loria, Giovanna, De Pandis, Mf, Federici, G, Manzo, V, Mauro, A, Picillo, M, Modugno, N, Lamberti, P, Dell'Aquila, C, Cicarelli, G, Quattrone, A, Nicoletti, G, Cannas, A, Solla, P, Nicoletti, A, Morgante, F, D'Amelio, M, Terruso, V, Elopra, R, Mucchiut, M, Pilleri, M, Biundi, R, Nassetti, S, Michelucci, R., Albanese, Alberto (ORCID:0000-0002-5864-0006), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Stocchi, Fabrizio, Antonini, Angelo, Barone, Paolo, Tinazzi, Michele, Zappia, Maria, Onofrj, Marco, Ruggieri, Stefano, Morgante, Letterio, Bonuccelli, Ubaldo, Lopiano, Leonardo, Pramstaller, Peter, Albanese, Alberto, Attar, Mahmood, Posocco, V, Colombo, D, Abbruzzese, Giovanni, Stocchi, F, Vacca, L, Pramstaller, Pp, Facheris, M, Guidotti, M, Mario, E, Riboldazzi, G, Leva, S, Priori, A, Pezzoli, G, Margherita, C, Soliveri, P, Picco, D, Pisano, F, Scarzella, L, Tavella, A, Zibetti, M, Ottaviani, S, Valzania, F, Contarsi, S, Quatrale, R, Sensi, M, Ceravolo, R, Rossi, C, Cincotta, M, Vanni, P, Del Dotto, P, Ceravolo, Mg, Capecci, M, Marchese, R, Tamburini, T, Thomas, A, Borelli, I, Marconi, R, Grasso, L, Stanzione, P, Pisani, V, Bentivoglio, Anna Rita, Loria, Giovanna, De Pandis, Mf, Federici, G, Manzo, V, Mauro, A, Picillo, M, Modugno, N, Lamberti, P, Dell'Aquila, C, Cicarelli, G, Quattrone, A, Nicoletti, G, Cannas, A, Solla, P, Nicoletti, A, Morgante, F, D'Amelio, M, Terruso, V, Elopra, R, Mucchiut, M, Pilleri, M, Biundi, R, Nassetti, S, Michelucci, R., Albanese, Alberto (ORCID:0000-0002-5864-0006), and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)

Abstract

Assessing the frequency of Wearing-Off (WO) in Parkinson's disease (PD) patients, and its impact on Quality of Life (QoL).

Published
2014

8. A double-blind, delayed-start trial of rasagiline in Parkinson's disease

Author

Olanow, C, Rascol, O, Hauser, R, Feigin, P, Jankovic, J, Lang, A, Langston, W, Melamed, E, Poewe, W, Stocchi, F, Tolosa, E, ADAGIO Study, I, Bueri, J, Garretto, N, Gershanik, O, Giannaula, R, Micheli, F, Wolf, E, Guttman, M, Hobson, D, Jog, M, King, D, Mendis, T, Miyasaki, J, Panisset, M, Pourcher, E, Rajput, A, Ranawaya, R, Tsui, J, Cesaro, P, Damier, P, Destee, A, Durif, F, Slaoui, T, Tison, F, Viallet, F, Deuschl, G, Gasser, T, Ludolph, A, Oehlwein, C, Przuntek, H, Reifschneider, G, Schnitzler, A, Trenkwalder, C, Bokor, M, Katona, A, Lajtos, J, Nikl, J, Takats, A, Valikovics, A, Badarny, S, Djaldetti, R, Giladi, N, Hassin, S, Rabey, J, Reches, A, Schwartz, M, Wirguin, I, Albanese, A, Bentivoglio, A, Bonuccelli, U, Calzetti, S, Comi, G, Curatola, L, Ferrarese, C, Lamberti, P, Marconi, R, Martignoni, E, Meco, G, Ruggieri, S, Bomhof, M, Hovestadt, A, Krul, J, Leenders, K, Cunha, L, Ferreira, J, Bajenaru, O, Carciumaru, N, Bulboaca, A, Pascu, I, Simu, M, Calopa, M, Fernández García, J, Kulisevsky, J, Linazasoro, C, Miquel, F, Posada, I, Martí, M, Burn, D, Macmahon, D, Barker, R, Allen, N, Barbour, P, Bertoni, J, Bharucha, K, Bose, S, Drasby, E, Elble, R, Elmer, L, Evans, B, Factor, S, Fernandez, H, Friedman, J, Hull, K, Golbe, L, Goudreau, J, Guttuso, T, Hassan, M, Hermanowicz, N, Houser, M, Hurtig, H, Isaacson, S, Jennings, D, Kompoliti, A, Morgan, J, Murphy, J, Nausieda, P, Pahwa, R, Parashos, S, O'Suilleabhain, P, Racette, B, Reich, S, Roberts, J, Rothstein, T, Sahay, A, Saint Hilaire, M, Schiess, M, Scott, B, Shahed, J, Simuni, T, Singer, C, Smith, R, Struck, L, Sutton, J, Swope, D, Tagliati, M, Tetrud, J, Togasaki, D, Watts, R, Olanow, CW, Feigin, PD, ADAGIO Study Investigators, Rabey, JM, FERRARESE, CARLO, Bomhof, MA, Krul, JM, Leenders, KL, Bajenaru, OA, Bulboaca, AC, Fernández García, JM, Posada, IJ, Martí, MJ, MacMahon, D, Watts, R., Olanow, C, Rascol, O, Hauser, R, Feigin, P, Jankovic, J, Lang, A, Langston, W, Melamed, E, Poewe, W, Stocchi, F, Tolosa, E, ADAGIO Study, I, Bueri, J, Garretto, N, Gershanik, O, Giannaula, R, Micheli, F, Wolf, E, Guttman, M, Hobson, D, Jog, M, King, D, Mendis, T, Miyasaki, J, Panisset, M, Pourcher, E, Rajput, A, Ranawaya, R, Tsui, J, Cesaro, P, Damier, P, Destee, A, Durif, F, Slaoui, T, Tison, F, Viallet, F, Deuschl, G, Gasser, T, Ludolph, A, Oehlwein, C, Przuntek, H, Reifschneider, G, Schnitzler, A, Trenkwalder, C, Bokor, M, Katona, A, Lajtos, J, Nikl, J, Takats, A, Valikovics, A, Badarny, S, Djaldetti, R, Giladi, N, Hassin, S, Rabey, J, Reches, A, Schwartz, M, Wirguin, I, Albanese, A, Bentivoglio, A, Bonuccelli, U, Calzetti, S, Comi, G, Curatola, L, Ferrarese, C, Lamberti, P, Marconi, R, Martignoni, E, Meco, G, Ruggieri, S, Bomhof, M, Hovestadt, A, Krul, J, Leenders, K, Cunha, L, Ferreira, J, Bajenaru, O, Carciumaru, N, Bulboaca, A, Pascu, I, Simu, M, Calopa, M, Fernández García, J, Kulisevsky, J, Linazasoro, C, Miquel, F, Posada, I, Martí, M, Burn, D, Macmahon, D, Barker, R, Allen, N, Barbour, P, Bertoni, J, Bharucha, K, Bose, S, Drasby, E, Elble, R, Elmer, L, Evans, B, Factor, S, Fernandez, H, Friedman, J, Hull, K, Golbe, L, Goudreau, J, Guttuso, T, Hassan, M, Hermanowicz, N, Houser, M, Hurtig, H, Isaacson, S, Jennings, D, Kompoliti, A, Morgan, J, Murphy, J, Nausieda, P, Pahwa, R, Parashos, S, O'Suilleabhain, P, Racette, B, Reich, S, Roberts, J, Rothstein, T, Sahay, A, Saint Hilaire, M, Schiess, M, Scott, B, Shahed, J, Simuni, T, Singer, C, Smith, R, Struck, L, Sutton, J, Swope, D, Tagliati, M, Tetrud, J, Togasaki, D, Watts, R, Olanow, CW, Feigin, PD, ADAGIO Study Investigators, Rabey, JM, FERRARESE, CARLO, Bomhof, MA, Krul, JM, Leenders, KL, Bajenaru, OA, Bulboaca, AC, Fernández García, JM, Posada, IJ, Martí, MJ, MacMahon, D, and Watts, R.

Abstract

BACKGROUND: A therapy that slows disease progression is the major unmet need in Parkinson's disease. METHODS: In this double-blind trial, we examined the possibility that rasagiline has disease-modifying effects in Parkinson's disease. A total of 1176 subjects with untreated Parkinson's disease were randomly assigned to receive rasagiline (at a dose of either 1 mg or 2 mg per day) for 72 weeks (the early-start group) or placebo for 36 weeks followed by rasagiline (at a dose of either 1 mg or 2 mg per day) for 36 weeks (the delayed-start group). To determine a positive result with either dose, the early-start treatment group had to meet each of three hierarchical end points of the primary analysis based on the Unified Parkinson's Disease Rating Scale (UPDRS, a 176-point scale, with higher numbers indicating more severe disease): superiority to placebo in the rate of change in the UPDRS score between weeks 12 and 36, superiority to delayed-start treatment in the change in the score between baseline and week 72, and noninferiority to delayed-start treatment in the rate of change in the score between weeks 48 and 72. RESULTS: Early-start treatment with rasagiline at a dose of 1 mg per day met all end points in the primary analysis: a smaller mean (+/-SE) increase (rate of worsening) in the UPDRS score between weeks 12 and 36 (0.09+/-0.02 points per week in the early-start group vs. 0.14+/-0.01 points per week in the placebo group, P=0.01), less worsening in the score between baseline and week 72 (2.82+/-0.53 points in the early-start group vs. 4.52+/-0.56 points in the delayed-start group, P=0.02), and noninferiority between the two groups with respect to the rate of change in the UPDRS score between weeks 48 and 72 (0.085+/-0.02 points per week in the early-start group vs. 0.085+/-0.02 points per week in the delayed-start group, P<0.001). All three end points were not met with rasagiline at a dose of 2 mg per day, since the change in the UPDRS score between baseline

Published
2009

9. Metric character of the quantum Jensen-Shannon divergence

Author

Lamberti, P. W., Majtey, A. P., Borras, A., Casas, Montserrat, Plastino, A., Lamberti, P. W., Majtey, A. P., Borras, A., Casas, Montserrat, and Plastino, A.

Abstract

In a recent paper, the generalization of the Jensen-Shannon divergence in the context of quantum theory has been studied [ Majtey et al. Phys. Rev. A 72 052310 (2005)]. This distance between quantum states has shown to verify several of the properties required for a good distinguishability measure. Here we investigate the metric character of this distance. More precisely we show, formally for pure states and by means of a numerical procedure for mixed states, that its square root verifies the triangle inequality.

Published
2008

10. Jensen Shannon divergence as a measure of the degree of entanglement

Author

Majtey, A. P., Borras, A., Casas, Montserrat, Lamberti, P. W., Plastino, A., Majtey, A. P., Borras, A., Casas, Montserrat, Lamberti, P. W., and Plastino, A.

Abstract

The notion of distance in Hilbert space is relevant in many scenarios. In particular, distances between quantum states play a central role in quantum information theory. An appropriate measure of distance is the quantum Jensen Shannon divergence (QJSD) between quantum states. Here we study this distance as a geometrical measure of entanglement and apply it to different families of states.

Published
2008

11. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy

Author

Brodie, M. J, Perucca, E, Ryvlin, P, Ben Menachem, E, Meencke, H. J, Van Landegem, W, Ossemann, M, Sadzot, B, Van Paesschen, W, Van Zandijcke, M, Hovorka, J, Marusic, P, Pazdera, L, Rektor, I, Stolcova, E, Tislerova, D, Kalviainen, R, Korpelainen, J, Peltola, J, Ranua, J, Geraud, G, Hirsch, E, Josien, E, Vercueil, L, Vespignani, H, Jeschke Rohrich, B, Keidel, M, Mattern, W, Ochs, G, Schmitz, B, Schumann, G, Balogh, A, Clemens, B, Czopf, J, Halasz, P, Rajna, P, Vecsei, L, Baruzzi, A, Beghi, A. E, Canevini, M. P, De Feo, M. R, Lamberti, P, Marciani, M. G, Marrosu, F, Mazza, Salvatore, Monaco, F, Mutani, R, Regesta, G, Zaccara, G, Drozdowski, W, Fryze, W, Jedrzejczak, J, Nowaki, P, Selmaj, K, Stelmasiak, Z, Wajgt, A, Bryer, A, Coetzee, C, Gardiner, J, Haug, P, Isaacs, M, Kelbe, C, Modi, G, Opperman, D, Shah, N, Wolberg, S, Arbizu, T, Forcadas, I, Macin Eiras, J. L, Martinez, M, Marti Masso, J. F, Molins, A, Serratosa, J. M, Borre, B, Kallen, K, Kumlien, E, Lindberger, M, Palm, R, Carpay, J. A, Sanders, E. A. C. M, Van Leusden, J. A, Vecht, C, Roberts, R. C, Smith, P, Tidswell, P., Brodie, M. J, Perucca, E, Ryvlin, P, Ben Menachem, E, Meencke, H. J, Van Landegem, W, Ossemann, M, Sadzot, B, Van Paesschen, W, Van Zandijcke, M, Hovorka, J, Marusic, P, Pazdera, L, Rektor, I, Stolcova, E, Tislerova, D, Kalviainen, R, Korpelainen, J, Peltola, J, Ranua, J, Geraud, G, Hirsch, E, Josien, E, Vercueil, L, Vespignani, H, Jeschke Rohrich, B, Keidel, M, Mattern, W, Ochs, G, Schmitz, B, Schumann, G, Balogh, A, Clemens, B, Czopf, J, Halasz, P, Rajna, P, Vecsei, L, Baruzzi, A, Beghi, A. E, Canevini, M. P, De Feo, M. R, Lamberti, P, Marciani, M. G, Marrosu, F, Mazza, Salvatore, Monaco, F, Mutani, R, Regesta, G, Zaccara, G, Drozdowski, W, Fryze, W, Jedrzejczak, J, Nowaki, P, Selmaj, K, Stelmasiak, Z, Wajgt, A, Bryer, A, Coetzee, C, Gardiner, J, Haug, P, Isaacs, M, Kelbe, C, Modi, G, Opperman, D, Shah, N, Wolberg, S, Arbizu, T, Forcadas, I, Macin Eiras, J. L, Martinez, M, Marti Masso, J. F, Molins, A, Serratosa, J. M, Borre, B, Kallen, K, Kumlien, E, Lindberger, M, Palm, R, Carpay, J. A, Sanders, E. A. C. M, Van Leusden, J. A, Vecht, C, Roberts, R. C, Smith, P, and Tidswell, P.

Published
2007

12. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

Author

Bonifati, V., Rohe, C.F., Breedveld, G.J., Fabrizio, E., Mari, M. De, Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D., Chien, H.F., Fincati, E., Abbruzzese, G., Marini, P., Gaetano, A. De, Horstink, M.W.I.M., Maat-Kievit, J.A., Sampaio, C., Antonini, A., Stocchi, F., Montagna, P., Toni, V., Guidi, M., Dalla Libera, A., Tinazzi, M., Pandis, F. De, Goldwurm, S., Klein, A. de, Barbosa, E., Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G., Oostra, B.A., Bonifati, V., Rohe, C.F., Breedveld, G.J., Fabrizio, E., Mari, M. De, Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D., Chien, H.F., Fincati, E., Abbruzzese, G., Marini, P., Gaetano, A. De, Horstink, M.W.I.M., Maat-Kievit, J.A., Sampaio, C., Antonini, A., Stocchi, F., Montagna, P., Toni, V., Guidi, M., Dalla Libera, A., Tinazzi, M., Pandis, F. De, Goldwurm, S., Klein, A. de, Barbosa, E., Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G., and Oostra, B.A.

Abstract

Item does not contain fulltext, OBJECTIVE: To assess the prevalence, nature, and associated phenotypes of PINK1 gene mutations in a large series of patients with early-onset (<50 years) parkinsonism. METHODS: The authors studied 134 patients (116 sporadic and 18 familial; 77% Italian) and 90 Italian controls. The whole PINK1 coding region was sequenced from genomic DNA; cDNA was analyzed in selected cases. RESULTS: Homozygous pathogenic mutations were identified in 4 of 90 Italian sporadic cases, including the novel Gln456Stop mutation; single heterozygous truncating or missense mutations were found in another 4 Italian sporadic cases, including two novel mutations, Pro196Leu and Gln456Stop. Pathogenic mutations were not identified in the familial cases. Novel (Gln115Leu) and known polymorphisms were identified with similar frequency in cases and controls. In cases carrying single heterozygous mutation, cDNA analysis detected no additional mutations, and revealed a major pathogenic effect at mRNA level for the mutant C1366T/Gln456Stop allele. All patients with homozygous mutations had very early disease onset, slow progression, and excellent response to l-dopa, including, in some, symmetric onset, dystonia at onset, and sleep benefit, resembling parkin-related disease. Phenotype in patients with single heterozygous mutation was similar, but onset was later. CONCLUSIONS: PINK1 homozygous mutations are a relevant cause of disease among Italian sporadic patients with early-onset parkinsonism. The role of mutations found in single heterozygous state is difficult to interpret. Our study suggests that, at least in some patients, these mutations are disease causing, in combination with additional, still unknown factors.

Published
2005

13. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

Author

Bonifati, V., Rohe, C.F., Breedveld, G.J., Fabrizio, E., Mari, M. De, Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D., Chien, H.F., Fincati, E., Abbruzzese, G., Marini, P., Gaetano, A. De, Horstink, M.W.I.M., Maat-Kievit, J.A., Sampaio, C., Antonini, A., Stocchi, F., Montagna, P., Toni, V., Guidi, M., Dalla Libera, A., Tinazzi, M., Pandis, F. De, Goldwurm, S., Klein, A. de, Barbosa, E., Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G., Oostra, B.A., Bonifati, V., Rohe, C.F., Breedveld, G.J., Fabrizio, E., Mari, M. De, Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D., Chien, H.F., Fincati, E., Abbruzzese, G., Marini, P., Gaetano, A. De, Horstink, M.W.I.M., Maat-Kievit, J.A., Sampaio, C., Antonini, A., Stocchi, F., Montagna, P., Toni, V., Guidi, M., Dalla Libera, A., Tinazzi, M., Pandis, F. De, Goldwurm, S., Klein, A. de, Barbosa, E., Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G., and Oostra, B.A.

Abstract

Item does not contain fulltext, OBJECTIVE: To assess the prevalence, nature, and associated phenotypes of PINK1 gene mutations in a large series of patients with early-onset (<50 years) parkinsonism. METHODS: The authors studied 134 patients (116 sporadic and 18 familial; 77% Italian) and 90 Italian controls. The whole PINK1 coding region was sequenced from genomic DNA; cDNA was analyzed in selected cases. RESULTS: Homozygous pathogenic mutations were identified in 4 of 90 Italian sporadic cases, including the novel Gln456Stop mutation; single heterozygous truncating or missense mutations were found in another 4 Italian sporadic cases, including two novel mutations, Pro196Leu and Gln456Stop. Pathogenic mutations were not identified in the familial cases. Novel (Gln115Leu) and known polymorphisms were identified with similar frequency in cases and controls. In cases carrying single heterozygous mutation, cDNA analysis detected no additional mutations, and revealed a major pathogenic effect at mRNA level for the mutant C1366T/Gln456Stop allele. All patients with homozygous mutations had very early disease onset, slow progression, and excellent response to l-dopa, including, in some, symmetric onset, dystonia at onset, and sleep benefit, resembling parkin-related disease. Phenotype in patients with single heterozygous mutation was similar, but onset was later. CONCLUSIONS: PINK1 homozygous mutations are a relevant cause of disease among Italian sporadic patients with early-onset parkinsonism. The role of mutations found in single heterozygous state is difficult to interpret. Our study suggests that, at least in some patients, these mutations are disease causing, in combination with additional, still unknown factors.

Published
2005

14. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

Author

Bonifati, V., Rohe, C.F., Breedveld, G.J., Fabrizio, E., Mari, M. De, Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D., Chien, H.F., Fincati, E., Abbruzzese, G., Marini, P., Gaetano, A. De, Horstink, M.W.I.M., Maat-Kievit, J.A., Sampaio, C., Antonini, A., Stocchi, F., Montagna, P., Toni, V., Guidi, M., Dalla Libera, A., Tinazzi, M., Pandis, F. De, Goldwurm, S., Klein, A. de, Barbosa, E., Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G., Oostra, B.A., Bonifati, V., Rohe, C.F., Breedveld, G.J., Fabrizio, E., Mari, M. De, Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D., Chien, H.F., Fincati, E., Abbruzzese, G., Marini, P., Gaetano, A. De, Horstink, M.W.I.M., Maat-Kievit, J.A., Sampaio, C., Antonini, A., Stocchi, F., Montagna, P., Toni, V., Guidi, M., Dalla Libera, A., Tinazzi, M., Pandis, F. De, Goldwurm, S., Klein, A. de, Barbosa, E., Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G., and Oostra, B.A.

Abstract

Item does not contain fulltext, OBJECTIVE: To assess the prevalence, nature, and associated phenotypes of PINK1 gene mutations in a large series of patients with early-onset (<50 years) parkinsonism. METHODS: The authors studied 134 patients (116 sporadic and 18 familial; 77% Italian) and 90 Italian controls. The whole PINK1 coding region was sequenced from genomic DNA; cDNA was analyzed in selected cases. RESULTS: Homozygous pathogenic mutations were identified in 4 of 90 Italian sporadic cases, including the novel Gln456Stop mutation; single heterozygous truncating or missense mutations were found in another 4 Italian sporadic cases, including two novel mutations, Pro196Leu and Gln456Stop. Pathogenic mutations were not identified in the familial cases. Novel (Gln115Leu) and known polymorphisms were identified with similar frequency in cases and controls. In cases carrying single heterozygous mutation, cDNA analysis detected no additional mutations, and revealed a major pathogenic effect at mRNA level for the mutant C1366T/Gln456Stop allele. All patients with homozygous mutations had very early disease onset, slow progression, and excellent response to l-dopa, including, in some, symmetric onset, dystonia at onset, and sleep benefit, resembling parkin-related disease. Phenotype in patients with single heterozygous mutation was similar, but onset was later. CONCLUSIONS: PINK1 homozygous mutations are a relevant cause of disease among Italian sporadic patients with early-onset parkinsonism. The role of mutations found in single heterozygous state is difficult to interpret. Our study suggests that, at least in some patients, these mutations are disease causing, in combination with additional, still unknown factors.

Published
2005

15. Astronáutica Kepleriana

Author

Lamberti, P. W. and Lamberti, P. W.

Abstract

En el presente trabajo se propone el cálculo de la órbita de un satélite artificial utilizando solo las Leyes de Kepler. Se respeta el bagaje de conceptos disponibles en la época de Kepler y se aprovecha este enfoque del problema de dos cuerpos en interacción gravitatoria para repasar algunos aspectos históricos y conceptuales de las Leyes de Kepler.

Published
1996

16. Astronáutica Kepleriana

Author

Lamberti, P. W. and Lamberti, P. W.

Abstract

En el presente trabajo se propone el cálculo de la órbita de un satélite artificial utilizando solo las Leyes de Kepler. Se respeta el bagaje de conceptos disponibles en la época de Kepler y se aprovecha este enfoque del problema de dos cuerpos en interacción gravitatoria para repasar algunos aspectos históricos y conceptuales de las Leyes de Kepler.

Published
1996

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