Search

Objective: To assess anti-tumour necrosis factor (anti-TNF) agents in patients with refractory systemic rheumatoid vasculitis (SRV). Methods: 1200 rheumatologists and internists were asked to provide medical files for patients with anti-TNF agents given as a second-line treatment for active SRV refractory to cyclophosphamide and glucocorticoids. Results: We identified nine cases in which anti-TNF drugs were given for active SRV, despite previous treatment with a mean cumulative dose of 8.4 g of cyclophosphamide in association with high-dose glucocorticoids. The mean prednisone dose before anti-TNF therapy was 29.6 mg/day. After 6 months, six patients were in remission (complete in five, partial in one). The treatment failed in one patient and two patients stopped taking the anti-TNF treatment due to side-effects. Mean prednisone dose was reduced to 11.2 mg/day. Severe infection occurred in three patients. Relapses were observed in two patients. Remission was re-established by reintroducing anti-TNF therapy in one case and increasing the dose in the other. Conclusions: This study provides evidence of efficacy of anti-TNF therapy in adjunct to glucocorticoids for treating active refractory SRV. Remission was achieved in two-thirds of patients, with a significant decrease in prednisone dose, although there was a high rate of infection in these severely ill patients., SCOPUS: ar.j, info:eu-repo/semantics/published

Radium is precipitated, with barium sulphate, from the drainage water by the addition of barium chloride; suspended solids are generally flocculated by aluminium salts (chloride, polychloride) or, if necessary, synthetic flocculants. Uranium, which may be present in some drainage water at a few mg/l, may be removed by the use of aluminium sulphate or sodium aluminate with the addition of a base if necessary. Examples of the teatment of uranium drainage water are given for Margrac (Haute-Vienne), Chardon (Vendee), Commanderie (Vendee), Cerilly (Allier) and Lodeve (Herault)., Radium is precipitated, with barium sulphate, from the drainage water by the addition of barium chloride; suspended solids are generally flocculated by aluminium salts (chloride, polychloride) or, if necessary, synthetic flocculants. Uranium, which may be present in some drainage water at a few mg/l, may be removed by the use of aluminium sulphate or sodium aluminate with the addition of a base if necessary. Examples of the teatment of uranium drainage water are given for Margrac (Haute-Vienne), Chardon (Vendee), Commanderie (Vendee), Cerilly (Allier) and Lodeve (Herault).

A large pilot plant at Bessines processes ore batches of several tons to design treatment flowsheets. Three examples are described: Cluff-D ore from Canada; ore from Niger; and ore from Lodeve. The limits of the pilot plant system are discussed., A large pilot plant at Bessines processes ore batches of several tons to design treatment flowsheets. Three examples are described: Cluff-D ore from Canada; ore from Niger; and ore from Lodeve. The limits of the pilot plant system are discussed.