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The relationship between cortical and trabecular bone and reproductive hormone production during perimenpausal transition is poorly understood. Our objective was to characterize associations between hormone production and radius and tibia bone and surrounding muscle properties in women. A prospective, observational pilot study was conducted in 30 healthy women (age 18-55 yrs). Concentrations of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), AntiMullerian Hormone (AMH), Inhibin A and B, Estradiol, and Progesterone were measured every 1-3 days during one interovulatory interval (IOI). Concentrations were recorded as the mean, minimum and maximum over the follicular and luteal phases and entire IOI, and mean day 2-4. Peripheral Quantitative Computed Tomography (pQCT) images were obtained to determine radius and tibia properties: trabecular bone area, content and density at the distal sites; cortical and marrow cavity (MC) areas, cortical content and density, muscle area and density (estimate of muscle fatness) at the shaft sites. Significant associations (p<0.05) between endocrine and pQCT outcomes were determined using Spearman rank correlation coefficients (rho). In radius, FSH was positively associated with trabecular area and content (rho: 0.37-0.40). AMH correlated negatively with trabecular area and content (-0.34 to -0.45). Inhibin B was negatively associated with trabecular area and content (-0.37 to -0.43). Forearm muscle density was positively associated with AMH (0.38) and Inhibin A and B (0.38 to 0.52). Progesterone correlated positively with cortical content and area (0.38-0.47). In tibia, FSH correlated positively with trabecular and MC areas (0.36 - 0.53) and negatively with muscle area (-0.49). LH was positively associated with trabecular content and area, and MC area (0.37 - 0.55). AMH correlated negatively with trabecular area (-0.36 to -0.49). Inhibin B was negatively associated with trabecular content and area (-0.37 to -0.43). Calf m

The relationship between cortical and trabecular bone and reproductive hormone production during perimenpausal transition is poorly understood. Our objective was to characterize associations between hormone production and radius and tibia bone and surrounding muscle properties in women. A prospective, observational pilot study was conducted in 30 healthy women (age 18-55 yrs). Concentrations of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), AntiMullerian Hormone (AMH), Inhibin A and B, Estradiol, and Progesterone were measured every 1-3 days during one interovulatory interval (IOI). Concentrations were recorded as the mean, minimum and maximum over the follicular and luteal phases and entire IOI, and mean day 2-4. Peripheral Quantitative Computed Tomography (pQCT) images were obtained to determine radius and tibia properties: trabecular bone area, content and density at the distal sites; cortical and marrow cavity (MC) areas, cortical content and density, muscle area and density (estimate of muscle fatness) at the shaft sites. Significant associations (p<0.05) between endocrine and pQCT outcomes were determined using Spearman rank correlation coefficients (rho). In radius, FSH was positively associated with trabecular area and content (rho: 0.37-0.40). AMH correlated negatively with trabecular area and content (-0.34 to -0.45). Inhibin B was negatively associated with trabecular area and content (-0.37 to -0.43). Forearm muscle density was positively associated with AMH (0.38) and Inhibin A and B (0.38 to 0.52). Progesterone correlated positively with cortical content and area (0.38-0.47). In tibia, FSH correlated positively with trabecular and MC areas (0.36 - 0.53) and negatively with muscle area (-0.49). LH was positively associated with trabecular content and area, and MC area (0.37 - 0.55). AMH correlated negatively with trabecular area (-0.36 to -0.49). Inhibin B was negatively associated with trabecular content and area (-0.37 to -0.43). Calf m