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Break-off of part of the down-going plate during continental collision occurs due to tensile stresses built-up between the deep and shallow slab, for which buoyancy is increased because of continental-crust subduction. Break-off governs the subsequent orogenic evolution but real-time observations are rare as it happens over geologically short times. Here we present a finite-frequency tomography, based on jointly inverted local and remote earthquakes, for the Hindu Kush in Afghanistan, where slab break-off is ongoing. We interpret our results as crustal subduction on top of a northwards-subducting Indian lithospheric slab, whose penetration depth increases along-strike while thinning and steepening. This implies that break-off is propagating laterally and that the highest lithospheric stretching rates occur during the final pinching-off. In the Hindu Kush crust, earthquakes and geodetic data show a transition from focused to distributed deformation, which we relate to a variable degree of crust-mantle coupling presumably associated with break-off at depth.

Break-off of part of the down-going plate during continental collision occurs due to tensile stresses built-up between the deep and shallow slab, for which buoyancy is increased because of continental-crust subduction. Break-off governs the subsequent orogenic evolution but real-time observations are rare as it happens over geologically short times. Here we present a finite-frequency tomography, based on jointly inverted local and remote earthquakes, for the Hindu Kush in Afghanistan, where slab break-off is ongoing. We interpret our results as crustal subduction on top of a northwards-subducting Indian lithospheric slab, whose penetration depth increases along-strike while thinning and steepening. This implies that break-off is propagating laterally and that the highest lithospheric stretching rates occur during the final pinching-off. In the Hindu Kush crust, earthquakes and geodetic data show a transition from focused to distributed deformation, which we relate to a variable degree of crust-mantle coupling presumably associated with break-off at depth.

CaTeNA – Climatic and Tectonic Natural Hazards in Central Asia – is an interdisciplinary, international project funded by the German Ministry of Education and Research to study natural hazards in Central Asia. Central Asia is one of the most tectonically active regions of the world and is influenced by both the west wind zone and monsoon. CaTeNA is examining the two most serious natural hazards arising from these conditions: Earthquakes and mass movements. The project goal is to better understand the underlying processes and triggering factors and to better estimate the resulting risks. For this purpose, CaTeNA localises tectonic faults and determines deformation rates and their changes. Focus is put on two of the most active fault systems, the Main Pamir Thrust and the Darvaz Fault crossing Tajikistan and Kyrgyzstan. We try to estimate recurrence intervals of large earthquakes and to understand their relationship to mass movements using paleo-seismology, geomorphology and remote sensing. The current deformation field is characterised and quantified using the methods of space geodesy and seismology. The results will be incorporated into the openly accessible Central Asian Tectonic Database developed within the project, making it accessible to the public, stakeholders and decision-makers. They form the basis for a more accurate estimation of the risk for earthquakes and landslides. Another important project goal is the development and implementation of a dynamic risk assessment for landslides, including high-resolution, model-based precipitation and snowmelt maps. This allows for improved estimation of the effects of geological hazards on inhabited areas and traffic infrastructure. Direct and efficient risk communication is achieved through interactive visualisation based on a dynamic multilingual web GIS platform. This is an essential step on the path to an early-warning system that takes into account the most important triggering factors. This data repository provi

Contains fulltext : 167787.pdf (publisher's version ) (Open Access), The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human genetic disorders. Here we describe an autosomal recessive human disease in two unrelated families characterized by a split-foot defect, nail abnormalities of the hands, and hearing loss, due to mutations disrupting the SAM domain of the protein kinase ZAK. ZAK is a member of the MAPKKK family with no known role in limb development. We show that Zak is expressed in the developing limbs and that a CRISPR/Cas-mediated knockout of the two Zak isoforms is embryonically lethal in mice. In contrast, a deletion of the SAM domain induces a complex hindlimb defect associated with down-regulation of Trp63, a known split-hand/split-foot malformation disease gene. Our results identify ZAK as a key player in mammalian limb patterning and demonstrate the rapid utility of CRISPR/Cas genome editing to assign causality to human mutations in the mouse in <10 wk.

Contains fulltext : 167787.pdf (publisher's version ) (Open Access), The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human genetic disorders. Here we describe an autosomal recessive human disease in two unrelated families characterized by a split-foot defect, nail abnormalities of the hands, and hearing loss, due to mutations disrupting the SAM domain of the protein kinase ZAK. ZAK is a member of the MAPKKK family with no known role in limb development. We show that Zak is expressed in the developing limbs and that a CRISPR/Cas-mediated knockout of the two Zak isoforms is embryonically lethal in mice. In contrast, a deletion of the SAM domain induces a complex hindlimb defect associated with down-regulation of Trp63, a known split-hand/split-foot malformation disease gene. Our results identify ZAK as a key player in mammalian limb patterning and demonstrate the rapid utility of CRISPR/Cas genome editing to assign causality to human mutations in the mouse in <10 wk.

Contains fulltext : 167787.pdf (publisher's version ) (Open Access), The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human genetic disorders. Here we describe an autosomal recessive human disease in two unrelated families characterized by a split-foot defect, nail abnormalities of the hands, and hearing loss, due to mutations disrupting the SAM domain of the protein kinase ZAK. ZAK is a member of the MAPKKK family with no known role in limb development. We show that Zak is expressed in the developing limbs and that a CRISPR/Cas-mediated knockout of the two Zak isoforms is embryonically lethal in mice. In contrast, a deletion of the SAM domain induces a complex hindlimb defect associated with down-regulation of Trp63, a known split-hand/split-foot malformation disease gene. Our results identify ZAK as a key player in mammalian limb patterning and demonstrate the rapid utility of CRISPR/Cas genome editing to assign causality to human mutations in the mouse in <10 wk.