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Zhiwei Jia,1 Donghua Liu,1 Xingxuan Li,1 Tianlin Wen,1 Wei Li2 1Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Tianlin Wen; Wei Li, Email wentianlin@bucm.edu.cn; weilichn@126.comPurpose: Intervertebral disc degeneration (IDD) is considered the predominant cause of low back pain (LBP) and accounts for global disability and a substantial socioeconomic burden. Given the unsatisfactory outcomes of current treatment strategies, cartilage endplate-derived stem cells (CESCs) are increasingly used in intervertebral disc regeneration. However, comprehensive analyses on CESCs remain rare. Herein, we examined the biological functions and applications of CESCs in IDD.Methods: PubMed, Embase, and Cochrane Library databases were searched to identify studies focused on CESCs. Relevant information from included studies was extracted. Descriptive statistics were performed. Correlation analysis was conducted to determine the relationship among Web of Science (WoS) citations, Dimensions, and Altmetric Attention Score (AAS).Results: Twenty-six studies were included in this study. Most studies (n=20) isolated CESCs from humans, followed by rats (n=5) and rabbits (n=1). Twenty studies were performed in vitro, and the remaining six were implemented both in vivo and in vitro. The findings of this study provide insight into the biological properties of CESCs and clarify their potential application for intervertebral disc regeneration. There was a very high correlation between WoS and Dimensions citation count (p< 0.001, r=0.988).Conclusion: This study, for the first time, elaborates biological features of CESCs and analyzes their potential applications in regenerating intervertebral discs. CESCs may be promising candidates for protecting the intervertebral disc from degeneration

Zhiwei Jia,1 Shunxin Zhang,2 Wei Li3 1Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 101100, People’s Republic of China; 2Department of Ultrasound, 2nd Medical Center of PLA General Hospital, Beijing, 100853, People’s Republic of China; 3Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of ChinaCorrespondence: Wei Li, Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of China, Email weilichn@126.com Shunxin Zhang, Department of Ultrasound, 2nd Medical Center of PLA General Hospital, Beijing, 100853, People’s Republic of China, Email zhangshunxin301@163.comAbstract: Degenerative bone disorders such as intervertebral disc degeneration (IVDD), osteoarthritis (OA), and osteoporosis (OP) pose significant health challenges for aging populations and lack effective treatment options. The field of regenerative medicine holds promise in addressing these disorders, with a focus on utilizing extracellular vesicles (EVs) derived from stem cells as an innovative therapeutic approach. EVs have shown great potential in stimulating biological responses, making them an attractive candidate for rejuvenating degenerative bone disorders. However, a comprehensive review summarizing the current state of this field and providing a clear assessment of EV-based therapies in degenerative bone disorders is currently deficient. In this review, we aim to fill the existing gap by outlining the current knowledge on the role of EVs derived from different types of stem cells, such as mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells, in bone regeneration. Furthermore, we discuss the therapeutic potential of EV-based treatments for IVDD, OA, and OP. By substantiating the use of stem cell-derived EVs, we highlight their promising potential as a cell-free strategy to improve degenerative b

Image ad understanding is a crucial task with wide real-world applications. Although highly challenging with the involvement of diverse atypical scenes, real-world entities, and reasoning over scene-texts, how to interpret image ads is relatively under-explored, especially in the era of foundational vision-language models (VLMs) featuring impressive generalizability and adaptability. In this paper, we perform the first empirical study of image ad understanding through the lens of pre-trained VLMs. We benchmark and reveal practical challenges in adapting these VLMs to image ad understanding. We propose a simple feature adaptation strategy to effectively fuse multimodal information for image ads and further empower it with knowledge of real-world entities. We hope our study draws more attention to image ad understanding which is broadly relevant to the advertising industry., Comment: ACL 2023

We study generalizable policy learning from demonstrations for complex low-level control tasks (e.g., contact-rich object manipulations). We propose an imitation learning method that incorporates the idea of temporal abstraction and the planning capabilities from Hierarchical RL (HRL) in a novel and effective manner. As a step towards decision foundation models, our design can utilize scalable, albeit highly sub-optimal, demonstrations. Specifically, we find certain short subsequences of the demos, i.e. the chain-of-thought (CoT), reflect their hierarchical structures by marking the completion of subgoals in the tasks. Our model learns to dynamically predict the entire CoT as coherent and structured long-term action guidance and consistently outperforms typical two-stage subgoal-conditioned policies. On the other hand, such CoT facilitates generalizable policy learning as they exemplify the decision patterns shared among demos (even those with heavy noises and randomness). Our method, Chain-of-Thought Predictive Control (CoTPC), significantly outperforms existing ones on challenging low-level manipulation tasks from scalable yet highly sub-optimal demos., Comment: Project page at https://zjia.eng.ucsd.edu/cotpc

Common-signal-induced synchronization of semiconductor lasers with optical feedback inspired a promising physical key distribution with information-theoretic security and potential in high rate. A significant challenge is the requirement to shorten the synchronization recovery time for increasing key rate without sacrificing operation parameter space for security. Here, open-loop synchronization of wavelength-tunable multi-section distributed Bragg reflector (DBR) lasers is proposed as a solution for physical-layer key distribution. Experiments show that the synchronization is sensitive to two operation parameters, i.e., currents of grating section and phase section. Furthermore, fast wavelength-shift keying synchronization can be achieved by direct modulation on one of the two currents. The synchronization recovery time is shortened by one order of magnitude compared to close-loop synchronization. An experimental implementation is demonstrated with a final key rate of 5.98 Mbit/s over 160 km optical fiber distance. It is thus believed that fast-tunable multi-section semiconductor lasers opens a new avenue of high-rate physical-layer key distribution using laser synchronization., Comment: 13 pages, 5 figures

Creativity is an indispensable part of human cognition and also an inherent part of how we make sense of the world. Metaphorical abstraction is fundamental in communicating creative ideas through nuanced relationships between abstract concepts such as feelings. While computer vision benchmarks and approaches predominantly focus on understanding and generating literal interpretations of images, metaphorical comprehension of images remains relatively unexplored. Towards this goal, we introduce MetaCLUE, a set of vision tasks on visual metaphor. We also collect high-quality and rich metaphor annotations (abstract objects, concepts, relationships along with their corresponding object boxes) as there do not exist any datasets that facilitate the evaluation of these tasks. We perform a comprehensive analysis of state-of-the-art models in vision and language based on our annotations, highlighting strengths and weaknesses of current approaches in visual metaphor Classification, Localization, Understanding (retrieval, question answering, captioning) and gEneration (text-to-image synthesis) tasks. We hope this work provides a concrete step towards developing AI systems with human-like creative capabilities., Comment: Accepted in CVPR 2023. Project page: https://metaclue.github.io/ , Video summary: https://youtu.be/V3TmeNETL-o

Recent years have witnessed an emerging paradigm shift toward embodied artificial intelligence, in which an agent must learn to solve challenging tasks by interacting with its environment. There are several challenges in solving embodied multimodal tasks, including long-horizon planning, vision-and-language grounding, and efficient exploration. We focus on a critical bottleneck, namely the performance of planning and navigation. To tackle this challenge, we propose a Neural SLAM approach that, for the first time, utilizes several modalities for exploration, predicts an affordance-aware semantic map, and plans over it at the same time. This significantly improves exploration efficiency, leads to robust long-horizon planning, and enables effective vision-and-language grounding. With the proposed Affordance-aware Multimodal Neural SLAM (AMSLAM) approach, we obtain more than 40% improvement over prior published work on the ALFRED benchmark and set a new state-of-the-art generalization performance at a success rate of 23.48% on the test unseen scenes., Comment: Accepted by IROS 2022

Generalization in deep reinforcement learning over unseen environment variations usually requires policy learning over a large set of diverse training variations. We empirically observe that an agent trained on many variations (a generalist) tends to learn faster at the beginning, yet its performance plateaus at a less optimal level for a long time. In contrast, an agent trained only on a few variations (a specialist) can often achieve high returns under a limited computational budget. To have the best of both worlds, we propose a novel generalist-specialist training framework. Specifically, we first train a generalist on all environment variations; when it fails to improve, we launch a large population of specialists with weights cloned from the generalist, each trained to master a selected small subset of variations. We finally resume the training of the generalist with auxiliary rewards induced by demonstrations of all specialists. In particular, we investigate the timing to start specialist training and compare strategies to learn generalists with assistance from specialists. We show that this framework pushes the envelope of policy learning on several challenging and popular benchmarks including Procgen, Meta-World and ManiSkill., Comment: ICML 2022

Scene text recognition (STR) is an important bridge between images and text, attracting abundant research attention. While convolutional neural networks (CNNS) have achieved remarkable progress in this task, most of the existing works need an extra module (context modeling module) to help CNN to capture global dependencies to solve the inductive bias and strengthen the relationship between text features. Recently, the transformer has been proposed as a promising network for global context modeling by self-attention mechanism, but one of the main shortcomings, when applied to recognition, is the efficiency. We propose a 1-D split to address the challenges of complexity and replace the CNN with the transformer encoder to reduce the need for a context modeling module. Furthermore, recent methods use a frozen initial embedding to guide the decoder to decode the features to text, leading to a loss of accuracy. We propose to use a learnable initial embedding learned from the transformer encoder to make it adaptive to different input images. Above all, we introduce a novel architecture for text recognition, named TRansformer-based text recognizer with Initial embedding Guidance (TRIG), composed of three stages (transformation, feature extraction, and prediction). Extensive experiments show that our approach can achieve state-of-the-art on text recognition benchmarks.

Learning-based methods for training embodied agents typically require a large number of high-quality scenes that contain realistic layouts and support meaningful interactions. However, current simulators for Embodied AI (EAI) challenges only provide simulated indoor scenes with a limited number of layouts. This paper presents Luminous, the first research framework that employs state-of-the-art indoor scene synthesis algorithms to generate large-scale simulated scenes for Embodied AI challenges. Further, we automatically and quantitatively evaluate the quality of generated indoor scenes via their ability to support complex household tasks. Luminous incorporates a novel scene generation algorithm (Constrained Stochastic Scene Generation (CSSG)), which achieves competitive performance with human-designed scenes. Within Luminous, the EAI task executor, task instruction generation module, and video rendering toolkit can collectively generate a massive multimodal dataset of new scenes for the training and evaluation of Embodied AI agents. Extensive experimental results demonstrate the effectiveness of the data generated by Luminous, enabling the comprehensive assessment of embodied agents on generalization and robustness., Comment: 2021 paper, Amazon

Although recent works based on deep learning have made progress in improving recognition accuracy on scene text recognition, how to handle low-quality text images in end-to-end deep networks remains a research challenge. In this paper, we propose an Iterative Fusion based Recognizer (IFR) for low quality scene text recognition, taking advantage of refined text images input and robust feature representation. IFR contains two branches which focus on scene text recognition and low quality scene text image recovery respectively. We utilize an iterative collaboration between two branches, which can effectively alleviate the impact of low quality input. A feature fusion module is proposed to strengthen the feature representation of the two branches, where the features from the Recognizer are Fused with image Restoration branch, referred to as RRF. Without changing the recognition network structure, extensive quantitative and qualitative experimental results show that the proposed method significantly outperforms the baseline methods in boosting the recognition accuracy of benchmark datasets and low resolution images in TextZoom dataset.

Object manipulation from 3D visual inputs poses many challenges on building generalizable perception and policy models. However, 3D assets in existing benchmarks mostly lack the diversity of 3D shapes that align with real-world intra-class complexity in topology and geometry. Here we propose SAPIEN Manipulation Skill Benchmark (ManiSkill) to benchmark manipulation skills over diverse objects in a full-physics simulator. 3D assets in ManiSkill include large intra-class topological and geometric variations. Tasks are carefully chosen to cover distinct types of manipulation challenges. Latest progress in 3D vision also makes us believe that we should customize the benchmark so that the challenge is inviting to researchers working on 3D deep learning. To this end, we simulate a moving panoramic camera that returns ego-centric point clouds or RGB-D images. In addition, we would like ManiSkill to serve a broad set of researchers interested in manipulation research. Besides supporting the learning of policies from interactions, we also support learning-from-demonstrations (LfD) methods, by providing a large number of high-quality demonstrations (~36,000 successful trajectories, ~1.5M point cloud/RGB-D frames in total). We provide baselines using 3D deep learning and LfD algorithms. All code of our benchmark (simulator, environment, SDK, and baselines) is open-sourced, and a challenge facing interdisciplinary researchers will be held based on the benchmark., Comment: NeurIPS 2021 Track on Datasets and Benchmarks; code: https://github.com/haosulab/ManiSkill

Recently, video scene text detection has received increasing attention due to its comprehensive applications. However, the lack of annotated scene text video datasets has become one of the most important problems, which hinders the development of video scene text detection. The existing scene text video datasets are not large-scale due to the expensive cost caused by manual labeling. In addition, the text instances in these datasets are too clear to be a challenge. To address the above issues, we propose a tracking based semi-automatic labeling strategy for scene text videos in this paper. We get semi-automatic scene text annotation by labeling manually for the first frame and tracking automatically for the subsequent frames, which avoid the huge cost of manual labeling. Moreover, a paired low-quality scene text video dataset named Text-RBL is proposed, consisting of raw videos, blurry videos, and low-resolution videos, labeled by the proposed convenient semi-automatic labeling strategy. Through an averaging operation and bicubic down-sampling operation over the raw videos, we can efficiently obtain blurry videos and low-resolution videos paired with raw videos separately. To verify the effectiveness of Text-RBL, we propose a baseline model combined with the text detector and tracker for video scene text detection. Moreover, a failure detection scheme is designed to alleviate the baseline model drift issue caused by complex scenes. Extensive experiments demonstrate that Text-RBL with paired low-quality videos labeled by the semi-automatic method can significantly improve the performance of the text detector in low-quality scenes., Comment: Published in: IEEE Access ( Early Access )

Many applications of unpaired image-to-image translation require the input contents to be preserved semantically during translations. Unaware of the inherently unmatched semantics distributions between source and target domains, existing distribution matching methods (i.e., GAN-based) can give undesired solutions. In particular, although producing visually reasonable outputs, the learned models usually flip the semantics of the inputs. To tackle this without using extra supervision, we propose to enforce the translated outputs to be semantically invariant w.r.t. small perceptual variations of the inputs, a property we call "semantic robustness". By optimizing a robustness loss w.r.t. multi-scale feature space perturbations of the inputs, our method effectively reduces semantics flipping and produces translations that outperform existing methods both quantitatively and qualitatively., Comment: Accepted to ICCV 2021

We study how to learn a policy with compositional generalizability. We propose a two-stage framework, which refactorizes a high-reward teacher policy into a generalizable student policy with strong inductive bias. Particularly, we implement an object-centric GNN-based student policy, whose input objects are learned from images through self-supervised learning. Empirically, we evaluate our approach on four difficult tasks that require compositional generalizability, and achieve superior performance compared to baselines., Comment: 34th Conference on Neural Information Processing Systems (NeurIPS 2020), Vancouver, Canada

We tackle the convolution neural networks (CNNs) backdoor detection problem by proposing a new representation called one-pixel signature. Our task is to detect/classify if a CNN model has been maliciously inserted with an unknown Trojan trigger or not. Here, each CNN model is associated with a signature that is created by generating, pixel-by-pixel, an adversarial value that is the result of the largest change to the class prediction. The one-pixel signature is agnostic to the design choice of CNN architectures, and how they were trained. It can be computed efficiently for a black-box CNN model without accessing the network parameters. Our proposed one-pixel signature demonstrates a substantial improvement (by around 30% in the absolute detection accuracy) over the existing competing methods for backdoored CNN detection/classification. One-pixel signature is a general representation that can be used to characterize CNN models beyond backdoor detection., Comment: Accepted at ECCV 2020

Recent advances in deep learning theory have evoked the study of generalizability across different local minima of deep neural networks (DNNs). While current work focused on either discovering properties of good local minima or developing regularization techniques to induce good local minima, no approach exists that can tackle both problems. We achieve these two goals successfully in a unified manner. Specifically, based on the observed Fisher information we propose a metric both strongly indicative of generalizability of local minima and effectively applied as a practical regularizer. We provide theoretical analysis including a generalization bound and empirically demonstrate the success of our approach in both capturing and improving the generalizability of DNNs. Experiments are performed on CIFAR-10, CIFAR-100 and ImageNet for various network architectures., Comment: ICML 2020

We study the intrinsic transformation of feature maps across convolutional network layers with explicit top-down control. To this end, we develop top-down feature transformer (TFT), under controllable parameters, that are able to account for the hidden layer transformation while maintaining the overall consistency across layers. The learned generators capture the underlying feature transformation processes that are independent of particular training images. Our proposed TFT framework brings insights to and helps the understanding of, an important problem of studying the CNN internal feature representation and transformation under the top-down processes. In the case of spatial transformations, we demonstrate the significant advantage of TFT over existing data-driven approaches in building data-independent transformations. We also show that it can be adopted in other applications such as data augmentation and image style transfer.