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Research regarding the intimate relationship between inflammation and coagulation in fracture hematoma has attracted increasing attention recently. However, the interaction of the two in the early fracture hematoma is not yet fully understood, especially the interplay between inflammatory and coagulation factor for hematoma structure. This review summarizes the interrelation between inflammation mediators and coagulation factors in the early fracture hematoma, and further delineates their influences on hematoma formation during fracture healing, thereby facilitating the advancement of knowledge of fracture hematoma and the development of new approaches to treat and manage bone fracture. The review leads to better understanding of the interrelation between inflammation mediators and coagulation factors in the early fracture hematoma, and their influences on hematoma formation in the beginning of fracture healing. Furthermore, development of therapies aimed at simultaneous modulation of both coagulation factors and inflammation factors that affect hematoma structure, rather than specific factors, may be most promising.