Search

Children in malaria-endemic regions can experience repeated Plasmodium infections over short periods of time. Effects of re-infection on multiple co-existing CD4+ T cell subsets remain unresolved. Here, we examine antigen-experienced CD4+ T cells during re-infection in mice, using scRNA-seq/TCR-seq and spatial transcriptomics. TCR transgenic TEM cells initiate rapid Th1/Tr1 recall responses prior to proliferating, while GC Tfh counterparts are refractory, with TCM/Tfh-like cells exhibiting modest non-proliferative responses. Th1-recall is a partial facsimile of primary Th1-responses, with no upregulated effector-associated genes being unique to recall. Polyclonal, TCR-diverse, CD4+ T cells exhibit similar recall dynamics, with individual clones giving rise to multiple effectors including highly proliferative Th1/Tr1 cells, as well as GC Tfh and Tfh-like cells lacking proliferative capacity. Thus, we show substantial diversity in recall responses mounted by multiple co-existing CD4+ T cell subsets in the spleen, and present graphical user interfaces for studying gene expression dynamics and clonal relationships during re-infection.

Item does not contain fulltext, Pfs230 is essential for Plasmodium falciparum transmission to mosquitoes and is the protein targeted by the most advanced malaria-transmission-blocking vaccine candidate. Prior understanding of functional epitopes on Pfs230 is based on two monoclonal antibodies (mAbs) with moderate transmission-reducing activity (TRA), elicited from subunit immunization. Here, we screened the B cell repertoire of two naturally exposed individuals possessing serum TRA and identified five potent mAbs from sixteen Pfs230 domain-1-specific mAbs. Structures of three potent and three low-activity antibodies bound to Pfs230 domain 1 revealed four distinct epitopes. Highly potent mAbs from natural infection recognized a common conformational epitope that is highly conserved across P. falciparum field isolates, while antibodies with negligible TRA derived from natural infection or immunization recognized three distinct sites. Our study provides molecular blueprints describing P. falciparum TRA, informed by contrasting potent and non-functional epitopes elicited by natural exposure and vaccination.

Item does not contain fulltext, Pfs230 is essential for Plasmodium falciparum transmission to mosquitoes and is the protein targeted by the most advanced malaria-transmission-blocking vaccine candidate. Prior understanding of functional epitopes on Pfs230 is based on two monoclonal antibodies (mAbs) with moderate transmission-reducing activity (TRA), elicited from subunit immunization. Here, we screened the B cell repertoire of two naturally exposed individuals possessing serum TRA and identified five potent mAbs from sixteen Pfs230 domain-1-specific mAbs. Structures of three potent and three low-activity antibodies bound to Pfs230 domain 1 revealed four distinct epitopes. Highly potent mAbs from natural infection recognized a common conformational epitope that is highly conserved across P. falciparum field isolates, while antibodies with negligible TRA derived from natural infection or immunization recognized three distinct sites. Our study provides molecular blueprints describing P. falciparum TRA, informed by contrasting potent and non-functional epitopes elicited by natural exposure and vaccination.

The MeerKAT Absorption Line Survey (MALS) has observed 391 telescope pointings at L-band (900 - 1670 MHz) at $\delta\lesssim$ $+20\deg$. We present radio continuum images and a catalog of 495,325 (240,321) radio sources detected at a signal-to-noise ratio (SNR) $>$5 over an area of 2289 deg$^2$ (1132 deg$^2$) at 1006 MHz (1381 MHz). Every MALS pointing contains a central bright radio source ($S_{1\,\mathrm{GHz}} \gtrsim 0.2$ Jy). The median spatial resolution is $12^{\prime\prime}$ ($8^{\prime\prime}$). The median rms noise away from the pointing center is 25 $\mu$Jy beam$^{-1}$ (22 $\mu$Jy beam$^{-1}$) and is within $\sim$ 15% of the achievable theoretical sensitivity. The flux density scale ratio and astrometric accuracy deduced from multiply observed sources in MALS are less than 1% (8% scatter) and $1^{\prime\prime}$, respectively. Through comparisons with NVSS and FIRST at 1.4 GHz, we establish the catalog's accuracy in the flux density scale and astrometry to be better than 6% (15% scatter) and $0.8^{\prime\prime}$, respectively. The median flux density offset is higher (9%) for an alternate beam model based on holographic measurements. The MALS radio source counts at 1.4 GHz are in agreement with literature. We estimate spectral indices ($\alpha$) of a subset of 125,621 sources (SNR$>$8), confirm the flattening of spectral indices with decreasing flux density and identify 140 ultra steep-spectrum ($\alpha<-1.3$) sources as prospective high-$z$ radio galaxies ($z>2$). We have identified 1308 variable and 122 transient radio sources comprising primarily of AGN that demonstrate long-term (26 years) variability in their observed flux densities. The MALS catalogs and images are publicly available at https://mals.iucaa.in., Comment: 64 pages, 25 figures, accepted for publication in the ApJS (full version of the paper with complete tables is available at DR1 release notes)

The number counts of homogeneous samples of radio sources are a tried and true method of probing the large scale structure of the Universe, as most radio sources outside the galactic plane are at cosmological distances. As such they are expected to trace the cosmic radio dipole, an anisotropy analogous to the dipole seen in the cosmic microwave background (CMB). Results have shown that although the cosmic radio dipole matches the direction of the CMB dipole, it has a significantly larger amplitude. This result challenges our assumption of the Universe being isotropic, which can have large repercussions for the current cosmological paradigm. Though significant measurements have been made, sensitivity to the radio dipole is generally hampered by systematic effects that can cause large biases in the measurement. Here we assess these systematics with data from the MeerKAT Absorption Line Survey (MALS). We present the analysis of ten MALS pointings, focusing on systematic effects that could lead to an inhomogeneous catalogue. We describe the calibration and creation of full band continuum images and catalogues, producing a combined catalogue containing 16,313 sources and covering 37.5 square degrees of sky down to a sensitivity of 10 $\mu$Jy/beam. We measure the completeness, purity, and flux recovery statistics for these catalogues using simulated data. We investigate different source populations in the catalogues by looking at flux densities and spectral indices, and how they might influence source counts. Using the noise characteristics of the pointings, we find global measures that can be used to correct for the incompleteness of the catalogue, producing corrected number counts down to 100 - 200 $\mu$Jy. We show that we can homogenise the catalogues and properly account for systematic effects. We determine that we can measure the dipole to $3\sigma$ significance with 100 MALS pointings., Comment: 30 pages, 25 figures. Accepted for publication in Astronomy & Astrophysics

T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the host and parasite factors that influence Tfh and functional antibody development. Here, we use samples from a large cross-sectional study of children residing in an area of high malaria transmission in Uganda to characterize Tfh cells and functional antibodies to multiple parasites stages. We identify a dramatic re-distribution of the Tfh cell compartment with age that is independent of malaria exposure, with Th2-Tfh cells predominating in early childhood, while Th1-Tfh cell gradually increase to adult levels over the first decade of life. Functional antibody acquisition is age-dependent and hierarchical acquired based on parasite stage, with merozoite responses followed by sporozoite and gametocyte antibodies. Antibodies are boosted in children with current infection, and are higher in females. The children with the very highest antibody levels have increased Tfh cell activation and proliferation, consistent with a key role of Tfh cells in antibody development. Together, these data reveal a complex relationship between the circulating Tfh compartment, antibody development and protection from malaria.

We present deep L-Band observations of the equatorial field centered on the z=6.3 SDSS QSO, reaching a 1 sigma sensitivity of ~2.5 uJy at the center of the field. We extracted a catalog of 1489 radio sources down to a flux density of ~12.5 uJy (5 sigma) over a field of view of ~ 30' diameter. We derived the source counts accounting for catalog reliability and completeness, and compared them with others available in the literature. Our source counts are among the deepest available so far, and, overall, are consistent with recent counts' determinations and models. We detected for the first time in the radio band the SDSS J1030+0524 QSO (26 +/- 5 uJy). We derived its optical radio loudness R_O = 0.62 +/- 0.12, which makes it the most radio quiet AGN at z >~ 6 discovered so far and detected at radio wavelengths. We unveiled extended diffuse radio emission associated with the lobes of a bright FRII radio galaxy located close to the center of the J1030 field, which is likely to become the future BCG of a protocluster at z=1.7. The lobes' complex morphology, coupled with the presence of X-ray diffuse emission detected around the FRII galaxy lobes, may point toward an interaction between the radio jets and the external medium. We also investigated the relation between radio and X-ray luminosity for a sample of 243 X-ray-selected objects obtained from 500 ks Chandra observations of the same field, and spanning a wide redshift range (0 ~< z ~< 3). Focused on sources with a spectroscopic redshift and classification, we found that sources hosted by ETG and AGN follow Log(L_R)/Log(L_X) linear correlations with slopes of ~0.6 and ~0.8, respectively. This is interpreted as a likely signature of different efficiency in the accretion process. Finally, we found that most of these sources (>~87%) show a radio-to-X-ray radio loudness R_X < -3.5, classifying these objects as radio quiet., Comment: 18 pages, 15 figures, 5 table. Accepted for publication in A&A

We report on the discovery and localization of fast radio bursts (FRBs) from the MeerTRAP project, a commensal fast radio transient-detection programme at MeerKAT in South Africa. Our hybrid approach combines a coherent search with an average field-of-view of 0.4 $\rm deg^{2}$ with an incoherent search utilizing a field-of-view of $\sim$1.27 $\rm deg^{2}$ (both at 1284~MHz). Here, we present results on the first three FRBs: FRB 20200413A (DM=1990.05 pc cm$^{-3}$), FRB 20200915A (DM=740.65 pc cm$^{-3}$), and FRB 20201123A (DM=433.55 pc cm$^{-3}$). FRB 20200413A was discovered only in the incoherent beam. FRB 20200915A (also discovered only in the incoherent beam) shows speckled emission in the dynamic spectrum which cannot be explained by interstellar scintillation in our Galaxy or plasma lensing, and might be intrinsic to the source. FRB 20201123A shows a faint post-cursor burst about 200 ms after the main burst and warrants further follow-up to confirm whether it is a repeating FRB. FRB 20201123A also exhibits significant temporal broadening consistent with scattering by a turbulent medium. The broadening exceeds that predicted for medium along the sightline through our Galaxy. We associate this scattering with the turbulent medium in the environment of the FRB in the host galaxy. Within the approximately $1'$ localization region of FRB 20201123A, we identify one luminous galaxy ($r \approx 15.67$; J173438.35$-$504550.4) that dominates the posterior probability for a host association. The galaxy's measured properties are consistent with other FRB hosts with secure associations., Comment: 14 pages, 9 figures, 3 tables, accepted for publication in MNRAS

In this work we performed a spectral energy distribution (SED) analysis in the optical/infrared band of the host galaxy of a proto-brightest cluster galaxy (BCG, NVSS J103023+052426) in a proto-cluster at z = 1.7. We found that it features a vigorous star formation rate (SFR) of ${\sim}$570 $\mathrm{M_{\odot}}$/yr and a stellar mass of $M_{\ast} \sim 3.7 \times 10^{11}$ $\mathrm{M_{\odot}}$; the high corresponding specific SFR = $1.5 \pm 0.5$ $\mathrm{Gyr^{-1}}$ classifies this object as a starburst galaxy that will deplete its molecular gas reservoir in $\sim$ $3.5 \times 10^8$ yr. Thus, this system represents a rare example of a proto-BCG caught during the short phase of its major stellar mass assembly. Moreover, we investigated the nature of the host galaxy emission at 3.3 mm. We found that it originates from the cold dust in the interstellar medium, even though a minor non-thermal AGN contribution cannot be completely ruled out. Finally, we studied the polarized emission of the lobes at 1.4 GHz. We unveiled a patchy structure where the polarization fraction increases in the regions in which the total intensity shows a bending morphology; in addition, the magnetic field orientation follows the direction of the bendings. We interpret these features as possible indications of an interaction with the intracluster medium. This strengthens the hypothesis of positive AGN feedback, as inferred in previous studies of this object on the basis of X-ray/mm/radio analysis. In this scenario, the proto-BCG heats the surrounding medium and possibly enhances the SFR in nearby galaxies., Comment: 13 pages, 3 figures, 1 table. Accepted for publication in Galaxies

In this work we performed a spectral energy distribution (SED) analysis in the optical/infrared band of the host galaxy of a proto-brightest cluster galaxy (BCG, NVSS J103023+052426) in a proto-cluster at z = 1.7. We found that it features a vigorous star formation rate (SFR) of ${\sim}$570 $\mathrm{M_{\odot}}$/yr and a stellar mass of $M_{\ast} \sim 3.7 \times 10^{11}$ $\mathrm{M_{\odot}}$; the high corresponding specific SFR = $1.5 \pm 0.5$ $\mathrm{Gyr^{-1}}$ classifies this object as a starburst galaxy that will deplete its molecular gas reservoir in $\sim$ $3.5 \times 10^8$ yr. Thus, this system represents a rare example of a proto-BCG caught during the short phase of its major stellar mass assembly. Moreover, we investigated the nature of the host galaxy emission at 3.3 mm. We found that it originates from the cold dust in the interstellar medium, even though a minor non-thermal AGN contribution cannot be completely ruled out. Finally, we studied the polarized emission of the lobes at 1.4 GHz. We unveiled a patchy structure where the polarization fraction increases in the regions in which the total intensity shows a bending morphology; in addition, the magnetic field orientation follows the direction of the bendings. We interpret these features as possible indications of an interaction with the intracluster medium. This strengthens the hypothesis of positive AGN feedback, as inferred in previous studies of this object on the basis of X-ray/mm/radio analysis. In this scenario, the proto-BCG heats the surrounding medium and possibly enhances the SFR in nearby galaxies., Comment: 13 pages, 3 figures, 1 table. Accepted for publication in Galaxies

The Large Survey Project (LSP) "MeerKAT Absorption Line Survey" (MALS) is a blind HI 21-cm and OH 18-cm absorption line survey in the L- and UHF-bands, with the primary goal to better determine the occurrence of atomic and molecular gas in the circum-galactic and inter-galactic medium, and its redshift evolution. Here we present the first results using the UHF-band, obtained towards the strongly lensed radio source PKS1830, detecting absorption in the lens galaxy. With merely 90min of data acquired on-source for science verification and processed using the Automated Radio Telescope Imaging Pipeline (ARTIP), we detect in absorption the known HI 21-cm and OH 18-cm main lines at z=0.89 at an unprecedented signal-to-noise ratio (4000 in the continuum, with 6km/s channels). For the first time we report the detection at z=0.89 of OH satellite lines, so far not detected at z $>$ 0.25. We decompose the OH lines into a thermal and a stimulated contribution, where the 1612 and 1720MHz lines are conjugate. The total OH 1720MHz emission line luminosity is 6100Lsun. This is the most luminous known 1720MHz maser line. The absorption components of the different images of the background source sample different light paths in the lensing galaxy, and their weights in the total absorption spectrum are expected to vary in time, on daily and monthly time scales. We compare our normalized spectra with those obtained more than 20 yrs ago, and find no variation. We interpret the absorption spectra with the help of a lens galaxy model, derived from an N-body hydro-dynamical simulation, with a morphology similar to its optical HST image. It is possible to reproduce the observations without invoking any central gas outflows. There are, however, distinct and faint high-velocity features, most likely high-velocity clouds. These clouds may contribute to broaden the HI and OH spectra., Comment: 13 pages, 11 figures, accepted in Astronomy and Astrophysics

The Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will observe several Deep Drilling Fields (DDFs) to a greater depth and with a more rapid cadence than the main survey. In this paper, we describe the 'DeepDrill' survey, which used the Spitzer Space Telescope Infrared Array Camera (IRAC) to observe three of the four currently defined DDFs in two bands, centred on 3.6 and 4.5 mu m. These observations expand the area that was covered by an earlier set of observations in these three fields by the Spitzer Extragalactic Representative Volume Survey (SERVS). The combined DeepDrill and SERVS data cover the footprints of the LSST DDFs in the Extended Chandra Deep Field-South (ECDFS) field, the ELAIS-S1 field (ES1), and the XMM-Large-Scale Structure Survey field (XMM-LSS). The observations reach an approximate 5s point-source depth of 2 mu Jy (corresponding to an AB magnitude of 23.1; sufficient to detect a 10(11) M-circle dot galaxy out to z approximate to 5) in each of the two bands over a total area of approximate to 29 deg(2). The dual-band catalogues contain a total of 2.35 million sources. In this paper, we describe the observations and data products from the survey, and an overview of the properties of galaxies in the survey. We compare the source counts to predictions from the SHARK semi-analytic model of galaxy formation. We also identify a population of sources with extremely red ([3.6]-[4.5] >1.2) colours which we show mostly consists of highly obscured active galactic nuclei.

The Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will observe several Deep Drilling Fields (DDFs) to a greater depth and with a more rapid cadence than the main survey. In this paper, we describe the 'DeepDrill' survey, which used the Spitzer Space Telescope Infrared Array Camera (IRAC) to observe three of the four currently defined DDFs in two bands, centred on 3.6 and 4.5 mu m. These observations expand the area that was covered by an earlier set of observations in these three fields by the Spitzer Extragalactic Representative Volume Survey (SERVS). The combined DeepDrill and SERVS data cover the footprints of the LSST DDFs in the Extended Chandra Deep Field-South (ECDFS) field, the ELAIS-S1 field (ES1), and the XMM-Large-Scale Structure Survey field (XMM-LSS). The observations reach an approximate 5s point-source depth of 2 mu Jy (corresponding to an AB magnitude of 23.1; sufficient to detect a 10(11) M-circle dot galaxy out to z approximate to 5) in each of the two bands over a total area of approximate to 29 deg(2). The dual-band catalogues contain a total of 2.35 million sources. In this paper, we describe the observations and data products from the survey, and an overview of the properties of galaxies in the survey. We compare the source counts to predictions from the SHARK semi-analytic model of galaxy formation. We also identify a population of sources with extremely red ([3.6]-[4.5] >1.2) colours which we show mostly consists of highly obscured active galactic nuclei.

Contains fulltext : 226803.pdf (publisher's version ) (Open Access)

We present details of the Automated Radio Telescope Imaging Pipeline (ARTIP) and results of a sensitive blind search for HI and OH absorbers at $z<0.4$ and $z<0.7$, respectively. ARTIP is written in Python 3.6, extensively uses the Common Astronomy Software Application (CASA) tools and tasks, and is designed to enable the geographically-distributed MeerKAT Absorption Line Survey (MALS) team to collaboratively process large volumes of radio interferometric data. We apply it to the first MALS dataset obtained using the 64-dish MeerKAT radio telescope and 32K channel mode of the correlator. With merely 40 minutes on target, we present the most sensitive spectrum of PKS1830-211 ever obtained and characterize the known HI ($z=0.19$) and OH ($z=0.89$) absorbers. We further demonstrate ARTIP's capabilities to handle realistic observing scenarios by applying it to a sample of 72 bright radio sources observed with the upgraded Giant Metrewave Radio Telescope (uGMRT) to blindly search for HI and OH absorbers. We estimate the numbers of HI and OH absorbers per unit redshift to be $n_{21}(z\sim0.18)<$0.14 and $n_{\rm OH}(z\sim0.40)<$0.12, respectively, and constrain the cold gas covering factor of galaxies at large impact parameters (50 kpc $<\rho<$ 150 kpc) to be less than 0.022. Due to the small redshift path, $\Delta z\sim$13 for HI with column density$>5.4\times10^{19}$ cm$^{-2}$, the survey has probed only the outskirts of star-forming galaxies at $\rho>30$ kpc. MALS with the expected $\Delta z\sim10^{3-4}$ will overcome this limitation and provide stringent constraints on the cold gas fraction of galaxies in diverse environments over $0

Contains fulltext : 226803.pdf (publisher's version ) (Open Access)

Contains fulltext : 226803.pdf (publisher's version ) (Open Access)

The Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will observe several Deep Drilling Fields (DDFs) to a greater depth and with a more rapid cadence than the main survey. In this paper, we describe the ``DeepDrill'' survey, which used the Spitzer Space Telescope Infrared Array Camera (IRAC) to observe three of the four currently defined DDFs in two bands, centered on 3.6 $\mu$m and 4.5 $\mu$m. These observations expand the area which was covered by an earlier set of observations in these three fields by the Spitzer Extragalactic Representative Volume Survey (SERVS). The combined DeepDrill and SERVS data cover the footprints of the LSST DDFs in the Extended Chandra Deep Field-South field (ECDFS), the ELAIS-S1 field (ES1), and the XMM Large-Scale Structure Survey field (XMM-LSS). The observations reach an approximate $5\sigma$ point-source depth of 2 $\mu$Jy (corresponding to an AB magnitude of 23.1; sufficient to detect a 10$^{11} M_{\odot}$ galaxy out to $z\approx 5$) in each of the two bands over a total area of $\approx 29\,$deg$^2$. The dual-band catalogues contain a total of 2.35 million sources. In this paper we describe the observations and data products from the survey, and an overview of the properties of galaxies in the survey. We compare the source counts to predictions from the SHARK semi-analytic model of galaxy formation. We also identify a population of sources with extremely red ([3.6]$-$[4.5] $>1.2$) colours which we show mostly consists of highly-obscured active galactic nuclei., Comment: 20 pages, 9 figures; MNRAS in press

We present details of the Automated Radio Telescope Imaging Pipeline (ARTIP) and results of a sensitive blind search for HI and OH absorbers at $z<0.4$ and $z<0.7$, respectively. ARTIP is written in Python 3.6, extensively uses the Common Astronomy Software Application (CASA) tools and tasks, and is designed to enable the geographically-distributed MeerKAT Absorption Line Survey (MALS) team to collaboratively process large volumes of radio interferometric data. We apply it to the first MALS dataset obtained using the 64-dish MeerKAT radio telescope and 32K channel mode of the correlator. With merely 40 minutes on target, we present the most sensitive spectrum of PKS1830-211 ever obtained and characterize the known HI ($z=0.19$) and OH ($z=0.89$) absorbers. We further demonstrate ARTIP's capabilities to handle realistic observing scenarios by applying it to a sample of 72 bright radio sources observed with the upgraded Giant Metrewave Radio Telescope (uGMRT) to blindly search for HI and OH absorbers. We estimate the numbers of HI and OH absorbers per unit redshift to be $n_{21}(z\sim0.18)<$0.14 and $n_{\rm OH}(z\sim0.40)<$0.12, respectively, and constrain the cold gas covering factor of galaxies at large impact parameters (50 kpc $<\rho<$ 150 kpc) to be less than 0.022. Due to the small redshift path, $\Delta z\sim$13 for HI with column density$>5.4\times10^{19}$ cm$^{-2}$, the survey has probed only the outskirts of star-forming galaxies at $\rho>30$ kpc. MALS with the expected $\Delta z\sim10^{3-4}$ will overcome this limitation and provide stringent constraints on the cold gas fraction of galaxies in diverse environments over $0

CASA, the Common Astronomy Software Applications package, is the primary data processing software for the Atacama Large Millimeter/submillimeter Array (ALMA) and NSF's Karl G. Jansky Very Large Array (VLA), and is frequently used also for other radio telescopes. The CASA software can process data from both single-dish and aperture-synthesis telescopes, and one of its core functionalities is to support the data reduction and imaging pipelines for ALMA, VLA and the VLA Sky Survey (VLASS). CASA has recently undergone several exciting new developments, including an increased flexibility in Python (CASA 6), support of Very Long Baseline Interferometry (VLBI), performance gains through parallel imaging, data visualization with the new Cube Analysis Rendering Tool for Astronomy (CARTA), enhanced reliability and testing, and modernized documentation. These proceedings of the 2019 Astronomical Data Analysis Software & Systems (ADASS) conference give an update of the CASA project, and detail how these new developments will enhance user experience of CASA., Comment: 4 pages, to appear in proceedings of ADASS XXIX, ASP Conf. Series

Serendipitously, we have rediscovered radio emission from the binary system Ross 867 (M4.5V) and Ross 868 (M3.5V) while inspecting archival Giant Metrewave Radio Telescope (GMRT) observations. The binary system consists of two M-dwarf stars that share common characteristics such as spectral type, astrometric parameters, age and emission at infrared, optical and X-rays frequencies. The GMRT data at 610 MHz taken on July 2011 shows that the radio emission from Ross 867 is polarized and highly variable on hour time scales with a peak flux of 10.4 $\pm$ 0.7 mJy/beam. Additionally, after reviewing archival data from several observatories (VLA, GMRT, JVLA and LOFAR), we confirm that although both stars are likely coeval, only Ross 867 has been detected, while Ross 868 remains undetected at radio wavelengths. As they have a a large orbital separation, this binary stellar system provides a coeval laboratory to examine and constrain the stellar properties linked to radio activity in M dwarfs. We speculate that the observed difference in radio activity between the dwarfs could be due to vastly different magnetic field topologies or that Ross 867 has an intrinsically different dynamo., Comment: Accepted for publication in A&A. Language edition included

CASA, the Common Astronomy Software Applications package, is the primary data processing software for the Atacama Large Millimeter/submillimeter Array (ALMA) and NSF's Karl G. Jansky Very Large Array (VLA), and is frequently used also for other radio telescopes. The CASA software can process data from both single-dish and aperture-synthesis telescopes, and one of its core functionalities is to support the data reduction and imaging pipelines for ALMA, VLA and the VLA Sky Survey (VLASS). CASA has recently undergone several exciting new developments, including an increased flexibility in Python (CASA 6), support of Very Long Baseline Interferometry (VLBI), performance gains through parallel imaging, data visualization with the new Cube Analysis Rendering Tool for Astronomy (CARTA), enhanced reliability and testing, and modernized documentation. These proceedings of the 2019 Astronomical Data Analysis Software & Systems (ADASS) conference give an update of the CASA project, and detail how these new developments will enhance user experience of CASA., Comment: 4 pages, to appear in proceedings of ADASS XXIX, ASP Conf. Series

Serendipitously, we have rediscovered radio emission from the binary system Ross 867 (M4.5V) and Ross 868 (M3.5V) while inspecting archival Giant Metrewave Radio Telescope (GMRT) observations. The binary system consists of two M-dwarf stars that share common characteristics such as spectral type, astrometric parameters, age and emission at infrared, optical and X-rays frequencies. The GMRT data at 610 MHz taken on July 2011 shows that the radio emission from Ross 867 is polarized and highly variable on hour time scales with a peak flux of 10.4 $\pm$ 0.7 mJy/beam. Additionally, after reviewing archival data from several observatories (VLA, GMRT, JVLA and LOFAR), we confirm that although both stars are likely coeval, only Ross 867 has been detected, while Ross 868 remains undetected at radio wavelengths. As they have a a large orbital separation, this binary stellar system provides a coeval laboratory to examine and constrain the stellar properties linked to radio activity in M dwarfs. We speculate that the observed difference in radio activity between the dwarfs could be due to vastly different magnetic field topologies or that Ross 867 has an intrinsically different dynamo., Comment: Accepted for publication in A&A. Language edition included

We present images taken using the Gemini South Adaptive Optics Imager (GSAOI) with the Gemini Multiconjugate Adaptive Optics System (GeMS) in three 2 arcmin$^2$ fields in the Spitzer Extragalactic Representative Volume Survey. These GeMS/GSAOI observations are among the first $\approx 0.1^{''}$ resolution data in the near-infrared spanning extragalactic fields exceeding $1.5^{\prime}$ in size. We use these data to estimate galaxy sizes, obtaining results similar to those from studies with the Hubble Space Telescope, though we find a higher fraction of compact star forming galaxies at $z>2$. To disentangle the star-forming galaxies from active galactic nuclei (AGN), we use multiwavelength data from surveys in the optical and infrared, including far-infrared data from Herschel, as well as new radio continuum data from the Australia Telescope Compact Array and Very Large Array. We identify ultraluminous infrared galaxies (ULIRGs) at $z \sim 1-3$, which consist of a combination of pure starburst galaxies and Active Galactic Nuclei (AGN)/starburst composites. The ULIRGs show signs of recent merger activity, such as highly disturbed morphologies and include a rare candidate triple AGN. We find that AGN tend to reside in hosts with smaller scale sizes than purely star-forming galaxies of similar infrared luminosity. Our observations demonstrate the potential for MCAO to complement the deeper galaxy surveys to be made with the James Webb Space Telescope., Comment: 20 pages, AJ, in press

We present a sub-kpc localization of the sites of supermassive black hole (SMBH) growth in three active galactic nuclei (AGN) at $z \sim 3$ in relation to the regions of intense star formation in their hosts. These AGNs are selected from Karl G. Jansky Very Large Array (VLA) and Atacama Large Millimeter/submillimeter Array (ALMA) observations in the HUDF and COSMOS, with the centimetric radio emission tracing both star formation and AGN, and the sub/millimeter emission by dust tracing nearly pure star formation. We require radio emission to be $\geqslant5\times$ more luminous than the level associated with the sub/millimeter star formation to ensure that the radio emission is AGN-dominated, thereby allowing localization of the AGN and star formation independently. In all three galaxies, the AGN are located within the compact regions of gas-rich, heavily obscured, intense nuclear star formation, with $R_e = 0.4-1.1$ kpc and average star formation rates of $\simeq100-1200$ $M_\odot$yr$^{-1}$. If the current episode of star formation continues at such a rate over the stellar mass doubling time of their hosts, $\simeq 0.2$ Gyr, the newly formed stellar mass will be of the order of $10^{11}$ $M_\odot$ within the central kpc region, concurrently and cospatially with significant growth of the SMBH. This is consistent with a picture of in-situ galactic bulge and SMBH formation. This work demonstrates the unique complementarity of VLA and ALMA observations to unambiguously pinpoint the locations of AGN and star formation down to $\simeq30$ mas, corresponding to $\simeq 230$ pc at $z = 3$., Comment: 7 pages, 3 figures, 2 tables. Accepted for publication in the Astrophysical Journal Letters

Ultra-steep spectrum (USS) radio sources are good tracers of powerful radio galaxies at $z > 2$. Identification of even a single bright radio galaxy at $z > 6$ can be used to detect redshifted 21cm absorption due to neutral hydrogen in the intervening IGM. Here we describe a new sample of high-redshift radio galaxy (HzRG) candidates constructed from the TGSS ADR1 survey at 150 MHz. We employ USS selection ($\alpha \le -1.3$) in $\sim10000$ square degrees, in combination with strict size selection and non-detections in all-sky optical and infrared surveys. We apply flux density cuts that probe a unique parameter space in flux density ($50 < S_{\textrm{150}} < 200$ mJy) to build a sample of 32 HzRG candidates. Follow-up Karl G. Jansky Very Large Array (VLA) observations at 1.4 GHz with an average beam size of $1.3$ arcseconds ($"$) revealed $\sim 48\%$ of sources to have a single radio component. P-band (370 MHz) imaging of 17 of these sources revealed a flattening radio SED for ten sources at low frequencies, which is expected from compact HzRGs. Two of our sources lie in fields where deeper multi-wavelength photometry and ancillary radio data are available and for one of these we find a best-fit photo-z of $4.8 \pm 2.0$. The other source has $z_{\textrm{phot}}=1.4 \pm 0.1$ and a small angular size ($3.7"$), which could be associated with an obscured star forming galaxy or with a "dead" elliptical. One USS radio source not part of the HzRG sample but observed with the VLA nonetheless is revealed to be a candidate giant radio galaxy with a host galaxy photo-z of $1.8\pm0.5$, indicating a size of 875 kpc., Comment: 17 pages, 13 figures, accepted for publication in MNRAS

BACKGROUND: Intermittent preventive treatment of malaria in pregnancy (IPTp) with dihydroartemisinin-piperaquine (IPTp-DP) has been shown to reduce the burden of malaria during pregnancy compared to sulfadoxine-pyrimethamine (IPTp-SP). However, limited data exist on how IPTp regimens impact malaria risk during infancy. We conducted a double-blinded randomized controlled trial (RCT) to test the hypothesis that children born to mothers given IPTp-DP would have a lower incidence of malaria during infancy compared to children born to mothers who received IPTp-SP. METHODS AND FINDINGS: We compared malaria metrics among children in Tororo, Uganda, born to women randomized to IPTp-SP given every 8 weeks (SP8w, n = 100), IPTp-DP every 8 weeks (DP8w, n = 44), or IPTp-DP every 4 weeks (DP4w, n = 47). After birth, children were given chemoprevention with DP every 12 weeks from 8 weeks to 2 years of age. The primary outcome was incidence of malaria during the first 2 years of life. Secondary outcomes included time to malaria from birth and time to parasitemia following each dose of DP given during infancy. Results are reported after adjustment for clustering (twin gestation) and potential confounders (maternal age, gravidity, and maternal parasitemia status at enrolment).The study took place between June 2014 and May 2017. Compared to children whose mothers were randomized to IPTp-SP8w (0.24 episodes per person year [PPY]), the incidence of malaria was higher in children born to mothers who received IPTp-DP4w (0.42 episodes PPY, adjusted incidence rate ratio [aIRR] 1.92; 95% CI 1.00-3.65, p = 0.049) and nonsignificantly higher in children born to mothers who received IPT-DP8w (0.30 episodes PPY, aIRR 1.44; 95% CI 0.68-3.05, p = 0.34). However, these associations were modified by infant sex. Female children whose mothers were randomized to IPTp-DP4w had an apparently 4-fold higher incidence of malaria compared to female children whose mothers were randomized to IPTp-SP8w (0.65 v

We present images taken using the Gemini South Adaptive Optics Imager (GSAOI) with the Gemini Multiconjugate Adaptive Optics System (GeMS) in three 2 arcmin$^2$ fields in the Spitzer Extragalactic Representative Volume Survey. These GeMS/GSAOI observations are among the first $\approx 0.1^{''}$ resolution data in the near-infrared spanning extragalactic fields exceeding $1.5^{\prime}$ in size. We use these data to estimate galaxy sizes, obtaining results similar to those from studies with the Hubble Space Telescope, though we find a higher fraction of compact star forming galaxies at $z>2$. To disentangle the star-forming galaxies from active galactic nuclei (AGN), we use multiwavelength data from surveys in the optical and infrared, including far-infrared data from Herschel, as well as new radio continuum data from the Australia Telescope Compact Array and Very Large Array. We identify ultraluminous infrared galaxies (ULIRGs) at $z \sim 1-3$, which consist of a combination of pure starburst galaxies and Active Galactic Nuclei (AGN)/starburst composites. The ULIRGs show signs of recent merger activity, such as highly disturbed morphologies and include a rare candidate triple AGN. We find that AGN tend to reside in hosts with smaller scale sizes than purely star-forming galaxies of similar infrared luminosity. Our observations demonstrate the potential for MCAO to complement the deeper galaxy surveys to be made with the James Webb Space Telescope., Comment: 20 pages, AJ, in press

We present a sub-kpc localization of the sites of supermassive black hole (SMBH) growth in three active galactic nuclei (AGN) at $z \sim 3$ in relation to the regions of intense star formation in their hosts. These AGNs are selected from Karl G. Jansky Very Large Array (VLA) and Atacama Large Millimeter/submillimeter Array (ALMA) observations in the HUDF and COSMOS, with the centimetric radio emission tracing both star formation and AGN, and the sub/millimeter emission by dust tracing nearly pure star formation. We require radio emission to be $\geqslant5\times$ more luminous than the level associated with the sub/millimeter star formation to ensure that the radio emission is AGN-dominated, thereby allowing localization of the AGN and star formation independently. In all three galaxies, the AGN are located within the compact regions of gas-rich, heavily obscured, intense nuclear star formation, with $R_e = 0.4-1.1$ kpc and average star formation rates of $\simeq100-1200$ $M_\odot$yr$^{-1}$. If the current episode of star formation continues at such a rate over the stellar mass doubling time of their hosts, $\simeq 0.2$ Gyr, the newly formed stellar mass will be of the order of $10^{11}$ $M_\odot$ within the central kpc region, concurrently and cospatially with significant growth of the SMBH. This is consistent with a picture of in-situ galactic bulge and SMBH formation. This work demonstrates the unique complementarity of VLA and ALMA observations to unambiguously pinpoint the locations of AGN and star formation down to $\simeq30$ mas, corresponding to $\simeq 230$ pc at $z = 3$., Comment: 7 pages, 3 figures, 2 tables. Accepted for publication in the Astrophysical Journal Letters

Ultra-steep spectrum (USS) radio sources are good tracers of powerful radio galaxies at $z > 2$. Identification of even a single bright radio galaxy at $z > 6$ can be used to detect redshifted 21cm absorption due to neutral hydrogen in the intervening IGM. Here we describe a new sample of high-redshift radio galaxy (HzRG) candidates constructed from the TGSS ADR1 survey at 150 MHz. We employ USS selection ($\alpha \le -1.3$) in $\sim10000$ square degrees, in combination with strict size selection and non-detections in all-sky optical and infrared surveys. We apply flux density cuts that probe a unique parameter space in flux density ($50 < S_{\textrm{150}} < 200$ mJy) to build a sample of 32 HzRG candidates. Follow-up Karl G. Jansky Very Large Array (VLA) observations at 1.4 GHz with an average beam size of $1.3$ arcseconds ($"$) revealed $\sim 48\%$ of sources to have a single radio component. P-band (370 MHz) imaging of 17 of these sources revealed a flattening radio SED for ten sources at low frequencies, which is expected from compact HzRGs. Two of our sources lie in fields where deeper multi-wavelength photometry and ancillary radio data are available and for one of these we find a best-fit photo-z of $4.8 \pm 2.0$. The other source has $z_{\textrm{phot}}=1.4 \pm 0.1$ and a small angular size ($3.7"$), which could be associated with an obscured star forming galaxy or with a "dead" elliptical. One USS radio source not part of the HzRG sample but observed with the VLA nonetheless is revealed to be a candidate giant radio galaxy with a host galaxy photo-z of $1.8\pm0.5$, indicating a size of 875 kpc., Comment: 17 pages, 13 figures, accepted for publication in MNRAS

Ultrasteep spectrum (USS) radio sources are good tracers of powerful radio galaxies at z > 2. Identification of even a single bright radio galaxy at z > 6 can be used to detect redshifted 21 cm absorption due to neutral hydrogen in the intervening intergalactic medium. Here we describe a new sample of high-redshift radio galaxy (HzRG) candidates constructed from the TIFR GMRT Sky Survey First Alternative Data Release survey at 150 MHz. We employ USS selection (a = -1.3) in ~10 000 deg2, in combination with strict size selection and non-detections in all-sky optical and infrared surveys. We apply flux density cuts that probe a unique parameter space in flux density (50mJy < S150 < 200 mJy) to build a sample of 32 HzRG candidates. Follow-up Karl G. Jansky Very Large Array (VLA) observations at 1.4 GHz with an average beam size of 1.3 arcsec revealed ~ 48 per cent of sources to have a single radio component. P-band (370 MHz) imaging of 17 of these sources revealed a flattening radio SED for 10 sources at low frequencies, which is expected from compact HzRGs. Two of our sources lie in fields where deeper multiwavelength photometry and ancillary radio data are available and for one of these we find a best-fitting photo-z of 4.8 ± 2.0. The other source has zphot = 1.4 ± 0.1 and a small angular size (3.7 arcsec), which could be associated with an obscured star-forming galaxy or with a 'dead' elliptical. One USS radio source not part of the HzRG sample but observed with the VLA none the less is revealed to be a candidate giant radio galaxy with a host galaxy photo-z of 1.8 ± 0.5, indicating a size of 875 kpc.

We describe an image-based method that uses two radio criteria, compactness, and spectral index, to identify promising pulsar candidates among Fermi Large Area Telescope (LAT) unassociated sources. These criteria are applied to those radio sources from the Giant Metrewave Radio Telescope all-sky survey at 150 MHz (TGSS ADR1) found within the error ellipses of unassociated sources from the 3FGL catalogue and a preliminary source list based on 7 yr of LAT data. After follow-up interferometric observations to identify extended or variable sources, a list of 16 compact, steep-spectrum candidates is generated. An ongoing search for pulsations in these candidates, in gamma rays and radio, has found 6 ms pulsars and one normal pulsar. A comparison of this method with existing selection criteria based on gamma-ray spectral and variability properties suggests that the pulsar discovery space using Fermi may be larger than previously thought. Radio imaging is a hitherto underutilized source selection method that can be used, as with other multiwavelength techniques, in the search for Fermi pulsars.

We describe an image-based method that uses two radio criteria, compactness and spectral index, to identify promising pulsar candidates among Fermi Large Area Telescope (LAT) unassociated sources. These criteria are applied to those radio sources from the Giant Metrewave Radio Telescope all-sky survey at 150 MHz (TGSS ADR1) found within the error ellipses of unassociated sources from the 3FGL catalog and a preliminary source list based on 7 years of LAT data. After follow-up interferometric observations to identify extended or variable sources, a list of 16 compact, steep-spectrum candidates is generated. An ongoing search for pulsations in these candidates, in gamma rays and radio, has found six millisecond pulsars and one normal pulsar. A comparison of this method with existing selection criteria based on gamma-ray spectral and variability properties suggests that the pulsar discovery space using Fermi may be larger than previously thought. Radio imaging is a hitherto underutilized source selection method that can be used, as with other multi-wavelength techniques, in the search for Fermi pulsars., Comment: MNRAS, in press (13 pages, 12 figures, 4 tables)

Next generation radio telescope arrays are being designed and commissioned to accurately measure polarized intensity and rotation measures across the entire sky through deep, wide-field radio interferometric surveys. Radio interferometer dish antenna arrays are affected by direction-dependent (DD) gains due to both instrumental and atmospheric effects. In this paper we demonstrate the effect of DD errors for parabolic dish antenna array on the measured polarized intensities of radio sources in interferometric images. We characterize the extent of polarimetric image degradation due to the DD gains through wide-band VLA simulations of representative point source simulations of the radio sky at L-Band(1-2GHz). We show that at the 0.5 gain level of the primary beam (PB) there is significant flux leakage from Stokes $I$ to $Q$, $U$ amounting to 10\% of the total intensity. We further demonstrate that while the instrumental response averages down for observations over large parallactic angle intervals, full-polarization DD correction is required to remove the effects of DD leakage. We also explore the effect of the DD beam on the Rotation Measure(RM) signals and show that while the instrumental effect is primarily centered around 0 rad-m$^{-2}$, the effect is significant over a broad range of RM requiring full polarization DD correction to accurately reconstruct RM synthesis signal., Comment: version2, 13 pages, 12 figures, accepted for publication in The Astronomical Journal

The Fermi Large Area Telescope has detected an extended region of GeV emission toward the Galactic Center that is currently thought to be powered by dark matter annihilation or a population of young and/or millisecond pulsars. In a test of the pulsar hypothesis, we have carried out an initial search of a 20 deg**2 area centered on the peak of the galactic center GeV excess. Candidate pulsars were identified as a compact, steep spectrum continuum radio source on interferometric images and followed with targeted single-dish pulsation searches. We report the discovery of the recycled pulsar PSR 1751-2737 with a spin period of 2.23 ms. PSR 1751-2737 appears to be an isolated recycled pulsar located within the disk of our Galaxy, and it is not part of the putative bulge population of pulsars that are thought to be responsible for the excess GeV emission. However, our initial success in this small pilot survey suggests that this hybrid method (i.e. wide-field interferometric imaging followed up with single dish pulsation searches) may be an efficient alternative strategy for testing whether a putative bulge population of pulsars is responsible for the GeV excess., Comment: MNRAS, in press

We present deep ALMA CO(5-4) observations of a main sequence, clumpy galaxy at z=1.5 in the HUDF. Thanks to the ~0.5" resolution of the ALMA data, we can link stellar population properties to the CO(5-4) emission on scales of a few kpc. We detect strong CO(5-4) emission from the nuclear region of the galaxy, consistent with the observed $L_{\rm IR}$-$L^{\prime}_{\rm CO(5-4)}$ correlation and indicating on-going nuclear star formation. The CO(5-4) gas component appears more concentrated than other star formation tracers or the dust distribution in this galaxy. We discuss possible implications of this difference in terms of star formation efficiency and mass build-up at the galaxy centre. Conversely, we do not detect any CO(5-4) emission from the UV-bright clumps. This might imply that clumps have a high star formation efficiency (although they do not display unusually high specific star formation rates) and are not entirely gas dominated, with gas fractions no larger than that of their host galaxy (~50%). Stellar feedback and disk instability torques funnelling gas towards the galaxy centre could contribute to the relatively low gas content. Alternatively, clumps could fall in a more standard star formation efficiency regime if their actual star-formation rates are lower than generally assumed. We find that clump star-formation rates derived with several different, plausible methods can vary by up to an order of magnitude. The lowest estimates would be compatible with a CO(5-4) non-detection even for main-sequence like values of star formation efficiency and gas content., Comment: Accepted for publication in MNRAS. Minor revisions to match published version

Dihydroartemisinin (DHA)-piperaquine is promising for malaria chemoprevention in pregnancy. We assessed the impacts of pregnancy and efavirenz-based antiretroviral therapy on exposure to DHA and piperaquine in pregnant Ugandan women. Intensive sampling was performed at 28 weeks gestation in 31 HIV-uninfected pregnant women, in 27 HIV-infected pregnant women receiving efavirenz, and in 30 HIV-uninfected nonpregnant women. DHA peak concentration and area under the concentration time curve (AUC0-8hr ) were 50% and 47% lower, respectively, and piperaquine AUC0-21d was 40% lower in pregnant women compared to nonpregnant women. DHA AUC0-8hr and piperaquine AUC0-21d were 27% and 38% lower, respectively, in pregnant women receiving efavirenz compared to HIV-uninfected pregnant women. Exposure to DHA and piperaquine were lower among pregnant women and particularly in women on efavirenz, suggesting a need for dose modifications. The study of modified dosing strategies for these populations is urgently needed.

We describe an image-based method that uses two radio criteria, compactness and spectral index, to identify promising pulsar candidates among Fermi Large Area Telescope (LAT) unassociated sources. These criteria are applied to those radio sources from the Giant Metrewave Radio Telescope all-sky survey at 150 MHz (TGSS ADR1) found within the error ellipses of unassociated sources from the 3FGL catalog and a preliminary source list based on 7 years of LAT data. After follow-up interferometric observations to identify extended or variable sources, a list of 16 compact, steep-spectrum candidates is generated. An ongoing search for pulsations in these candidates, in gamma rays and radio, has found six millisecond pulsars and one normal pulsar. A comparison of this method with existing selection criteria based on gamma-ray spectral and variability properties suggests that the pulsar discovery space using Fermi may be larger than previously thought. Radio imaging is a hitherto underutilized source selection method that can be used, as with other multi-wavelength techniques, in the search for Fermi pulsars., Comment: MNRAS, in press (13 pages, 12 figures, 4 tables)

Next generation radio telescope arrays are being designed and commissioned to accurately measure polarized intensity and rotation measures across the entire sky through deep, wide-field radio interferometric surveys. Radio interferometer dish antenna arrays are affected by direction-dependent (DD) gains due to both instrumental and atmospheric effects. In this paper we demonstrate the effect of DD errors for parabolic dish antenna array on the measured polarized intensities of radio sources in interferometric images. We characterize the extent of polarimetric image degradation due to the DD gains through wide-band VLA simulations of representative point source simulations of the radio sky at L-Band(1-2GHz). We show that at the 0.5 gain level of the primary beam (PB) there is significant flux leakage from Stokes $I$ to $Q$, $U$ amounting to 10\% of the total intensity. We further demonstrate that while the instrumental response averages down for observations over large parallactic angle intervals, full-polarization DD correction is required to remove the effects of DD leakage. We also explore the effect of the DD beam on the Rotation Measure(RM) signals and show that while the instrumental effect is primarily centered around 0 rad-m$^{-2}$, the effect is significant over a broad range of RM requiring full polarization DD correction to accurately reconstruct RM synthesis signal., Comment: version2, 13 pages, 12 figures, accepted for publication in The Astronomical Journal

The Fermi Large Area Telescope has detected an extended region of GeV emission toward the Galactic Center that is currently thought to be powered by dark matter annihilation or a population of young and/or millisecond pulsars. In a test of the pulsar hypothesis, we have carried out an initial search of a 20 deg**2 area centered on the peak of the galactic center GeV excess. Candidate pulsars were identified as a compact, steep spectrum continuum radio source on interferometric images and followed with targeted single-dish pulsation searches. We report the discovery of the recycled pulsar PSR 1751-2737 with a spin period of 2.23 ms. PSR 1751-2737 appears to be an isolated recycled pulsar located within the disk of our Galaxy, and it is not part of the putative bulge population of pulsars that are thought to be responsible for the excess GeV emission. However, our initial success in this small pilot survey suggests that this hybrid method (i.e. wide-field interferometric imaging followed up with single dish pulsation searches) may be an efficient alternative strategy for testing whether a putative bulge population of pulsars is responsible for the GeV excess., Comment: MNRAS, in press

We present deep ALMA CO(5-4) observations of a main sequence, clumpy galaxy at z=1.5 in the HUDF. Thanks to the ~0.5" resolution of the ALMA data, we can link stellar population properties to the CO(5-4) emission on scales of a few kpc. We detect strong CO(5-4) emission from the nuclear region of the galaxy, consistent with the observed $L_{\rm IR}$-$L^{\prime}_{\rm CO(5-4)}$ correlation and indicating on-going nuclear star formation. The CO(5-4) gas component appears more concentrated than other star formation tracers or the dust distribution in this galaxy. We discuss possible implications of this difference in terms of star formation efficiency and mass build-up at the galaxy centre. Conversely, we do not detect any CO(5-4) emission from the UV-bright clumps. This might imply that clumps have a high star formation efficiency (although they do not display unusually high specific star formation rates) and are not entirely gas dominated, with gas fractions no larger than that of their host galaxy (~50%). Stellar feedback and disk instability torques funnelling gas towards the galaxy centre could contribute to the relatively low gas content. Alternatively, clumps could fall in a more standard star formation efficiency regime if their actual star-formation rates are lower than generally assumed. We find that clump star-formation rates derived with several different, plausible methods can vary by up to an order of magnitude. The lowest estimates would be compatible with a CO(5-4) non-detection even for main-sequence like values of star formation efficiency and gas content., Comment: Accepted for publication in MNRAS. Minor revisions to match published version

The Fermi Large Area Telescope has detected an extended region of GeV emission towards the Galactic Centre that is currently thought to be powered by dark matter annihilation or a population of young and/or millisecond pulsars. In a test of the pulsar hypothesis, we have carried out an initial search of a 20 deg2 area centred on the peak of the galactic centre GeV excess. Candidate pulsars were identified as a compact, steep spectrum continuum radio source on interferometric images and followed with targeted single-dish pulsation searches. We report the discovery of the recycled pulsar PSR 1751−2737 with a spin period of 2.23 ms. PSR 1751−2737 appears to be an isolated recycled pulsar located within the disc of our Galaxy, and it is not part of the putative bulge population of pulsars that are thought to be responsible for the excess GeV emission. However, our initial success in this small pilot survey suggests that this hybrid method (i.e. wide-field interferometric imaging followed up with single-dish pulsation searches) may be an efficient alternative strategy for testing whether a putative bulge population of pulsars is responsible for the GeV excess.

We present the first full release of a survey of the 150 MHz radio sky, observed with the Giant Metrewave Radio Telescope (GMRT) between April 2010 and March 2012 as part of the TIFR GMRT Sky Survey (TGSS) project. Aimed at producing a reliable compact source survey, our automated data reduction pipeline efficiently processed more than 2000 h of observations with minimal human interaction. Through application of innovative techniques such as image-based flagging, direction-dependent calibration of ionospheric phase errors, correcting for systematic offsets in antenna pointing, and improving the primary beam model, we created good quality images for over 95 percent of the 5336 pointings. Our data release covers 36 900 deg2 (or 3.6 p steradians) of the sky between-53° and +90° declination (Dec), which is 90 percent of the total sky. The majority of pointing images have a noise level below 5 mJy beam-1 with an approximate resolution of 25''×25'' (or 25''×25''/cos(Dec-19°) for pointings south of 19° declination). We have produced a catalog of 0.62 Million radio sources derived from an initial, high reliability source extraction at the seven sigma level. For the bulk of the survey, the measured overall astrometric accuracy is better than two arcseconds in right ascension and declination, while the flux density accuracy is estimated at approximately ten percent. Within the scope of the TGSS alternative data release (TGSS ADR) project, the source catalog, as well as 5336 mosaic images (5°×5°) and an image cutout service, are made publicly available at the CDS as a service to the astronomical community. Next to enabling a wide range of different scientific investigations, we anticipate that these survey products will provide a solid reference for various new low-frequency radio aperture array telescopes (LOFAR, LWA, MWA, SKA-low), and can play an important role in characterizing the epoch-of-reionisation (EoR) foreground. The TGSS ADR project aims at continuously improving

We present a search for transient and highly variable sources at low radio frequencies (150-200 MHz) that explores long timescales of 1-3 years. We conducted this search by comparing the TIFR GMRT Sky Survey Alternative Data Release 1 (TGSS ADR1) and the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey catalogues. To account for the different completeness thresholds in the individual surveys, we searched for compact GLEAM sources above a flux density limit of 100 mJy that were not present in the TGSS ADR1; and also for compact TGSS ADR1 sources above a flux density limit of 200 mJy that had no counterpart in GLEAM. From a total sample of 234 333 GLEAM sources and 275 612 TGSS ADR1 sources in the overlap region between the two surveys, there were 99658 GLEAM sources and 38 978 TGSS ADR sources that passed our flux density cutoff and compactness criteria. Analysis of these sources resulted in three candidate transient sources. Further analysis ruled out two candidates as imaging artefacts. We analyse the third candidate and show it is likely to be real, with a flux density of 182 +/- 26 mJy at 147.5 MHz. This gives a transient surface density of rho = (6.2 +/- 6) x 10-5 deg-2 . We present initial follow-up observations and discuss possible causes for this candidate. The small number of spurious sources from this search demonstrates the high reliability of these two new low-frequency radio catalogues.

Contains fulltext : 172114.pdf (publisher's version ) (Open Access), BACKGROUND: Parasite prevalence is a key metric used to quantify the burden of malaria and assess the impact of control strategies. Most published estimates of parasite prevalence are based on microscopy and likely underestimate true prevalence. METHODS: Thick smear microscopy was performed in cohorts of children (aged 6 month to 10 years) and adults every 90 days over 2 years, at three sites of varying transmission intensity in Uganda. Microscopy-negative samples were tested for sub-microscopic parasitaemia using loop-mediated isothermal amplification (LAMP). Generalized estimating equation models were used to evaluate associations between age and parasitaemia, factors associated with sub-microscopic infection and associations between parasitaemia and haemoglobin. RESULTS: A total of 9260 samples were collected from 1245 participants. Parasite prevalence among children across the three sites was 7.4, 9.4 and 28.8 % by microscopy and 21.3, 31.8 and 69.0 % by microscopy plus LAMP. Parasite prevalence among adults across the three sites was 3.1, 3.0 and 5.2 % by microscopy and 18.8, 24.2 and 53.5 % by microscopy plus LAMP. Among those with parasitaemia, adults and persons recently treated with anti-malarial therapy had the highest prevalence of sub-microscopic infection. Children with sub-microscopic or microscopic parasitaemia had lower mean haemoglobin levels compared to children with no detectable parasites. CONCLUSIONS: Across a range of transmission intensities in Uganda, microscopy vastly underestimated parasite prevalence, especially among adults.