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1. Smjernice za dijagnostiku i liječenje odraslih bolesnika s Fabryjevom bolesti

Author: Pećin, Ivan, Merćep, Iveta, Bašić-Kes, Vanja, Bilić, Ervina, Borovečki, Fran, Bradamante, Mirna, Čikeš, Maja, Fumić, Ksenija, Godan Hauptman, Ana, Jelaković, Bojan, Leskovar, Dunja, Paponja Mihanović, Kristina, Perica, Dražen, Prgomet, Luka, Rački, Sanjin, Selthofer-Relatić, Kristina, Štanfel, Marija, Šućur, Nediljko, Vujičić, Božidar, Vukić, Tamara, Reiner, Željko, Pećin, Ivan, Merćep, Iveta, Bašić-Kes, Vanja, Bilić, Ervina, Borovečki, Fran, Bradamante, Mirna, Čikeš, Maja, Fumić, Ksenija, Godan Hauptman, Ana, Jelaković, Bojan, Leskovar, Dunja, Paponja Mihanović, Kristina, Perica, Dražen, Prgomet, Luka, Rački, Sanjin, Selthofer-Relatić, Kristina, Štanfel, Marija, Šućur, Nediljko, Vujičić, Božidar, Vukić, Tamara, and Reiner, Željko
Abstract: Anderson-Fabryjeva bolest metabolička je bolest nakupljanja glikolipida u lizosomima. Multidisiciplinarni pristup neophodan je za rano prepoznavanje, liječenje i prevenciju komplikacija u oboljelih. Ove smjernice nadopuna su smjernica publiciranih u ime Referentnog centra za rijetke i metaboličke bolesti 2014. godine u Liječničkom vjesniku s obzirom na nove dijagnostičke postupke, biljege i terapijske opcije, suradnjom specijalista iz centara izvrsnosti te multidisciplinarnog tima Referentnog centra za rijetke i metaboličke bolesti odraslih Ministarstva zdravstva Republike Hrvatske. Smjernice su prezentirane na godišnjem sastanku Hrvatskog društva za rijetke bolesti Hrvatskoga liječničkog zbora te su jednoglasno prihvaćene., Anderson-Fabry disease is a metabolic disease of accumulation of glycolipids in lysosomes. A multidisciplinary approach is necessary for early recognition, treatment and prevention of complications in patients. These guidelines are a supplement to the guidelines published by the Reference Center for Rare and Metabolic Diseases in 2014 in the Medical Journal with regard to new diagnostic procedures, markers and therapeutic options, with the cooperation of specialists from centers of excellence and the multidisciplinary team of the Reference Center for Rare and Metabolic Diseases of Adults of the Ministry of Health of the Republic of Croatia. The guidelines were presented at the annual meeting of the Croatian Society for Rare Diseases of the Croatian Medical Association and unanimously accepted.
Published: 2024

2. Warsaw communiqué on climate change in Europe

Author: Jelaković, Bojan and Jelaković, Bojan
Published: 2023

3. Prevalence of prediabetes and risk factors in the general adult population of Croatia - EH-UH 2 study

Author: Prgomet, Luka, Skelin, Juraj, Domislović, Marija, Jelaković, Bojan, Prgomet, Luka, Skelin, Juraj, Domislović, Marija, and Jelaković, Bojan
Abstract: Introduction: Prediabetes is a state of elevated blood glucose, but not high enough to be classified as diabetes. The prevalence depends on the criteria used in the definition of prediabetes and on the observed populations. Known risk factors are obesity, age ≥ 45 years, positive family history of type 2 diabetes, insufficient physical activity, arterial hypertension, dyslipidaemia, and positive smoking status. The aim of our study was to determine the prevalence of prediabetes in a randomized, repre- sentative sample of the adult population of the Republic of Croatia and to determine the association and predictability of risk factors. Materials and methods: Out of 1219 adult participants who were involved in the scientific research project EHUH-2, 687 met the final criteria. All participants underwent clinical examination. Personal and family history were obtained from the collected data in the questionnaire. The participants were instructed to fast for 12 hours before the blood draw and were given detailed instructions on collecting a 24-hour urine sample. According to the ADA criteria, prediabetes is defined as a fasting glucose value between 5.6, and 6.9 mmol/L. Results: The prevalence of prediabetes in our sample was 11.1%. Predictive factors for prediabetes were older age, male gender, higher body weight, higher body mass index, larger waist circumference, higher systolic and diastolic blood pressure, larger body surface area, a higher percentage of visceral fat, decreased glomerular filtration rate, higher serum uric acid levels, and greater albuminuria (ACR). The final hierarchical regression model, which included body mass index, systolic and diastolic blood pres- sure, waist circumference, age, gender, eGFR, information on smoking, albuminuria, and urate, was statistically significant (p < ; 0.001; Nagelkerke R2=0,272). Conclusion: Our study is the first in which the prevalence of prediabetes and its association with risk factors were determined in a repre
Published: 2023

4. Uromodulin – a Link between Sodium Excretion and Alteration in Circadian Blood Pressure Pattern in Prehypertensives

Author: Josipović, Josipa, Šimičević, Livija, Dika, Živka, Bulj, Nikola, Vrsalović, Mislav, Jelaković, Bojan, Josipović, Josipa, Šimičević, Livija, Dika, Živka, Bulj, Nikola, Vrsalović, Mislav, and Jelaković, Bojan
Abstract: Although changes in dietary sodium intake alter blood pressure (BP) in salt-sensitive individuals, pathophysiological mechanisms are still unknown. It has been reported that uromodulin is involved in sodium tubular transport, and genome-wide association studies pointed to UMOD gene as one of the most important gene candidates for arterial hypertension. Our aim was to analyze urinary uromodulin, salt intake and BP in 326 young middle-aged subjects (mean age 36±8 years, 49.4% male). In a subgroup of 175 individuals, ambulatory blood pressure monitoring and echocardiogram were performed. Uromodulin was determined by ELISA. According to the JNC-7 criteria, subjects were classified as optimal BP (n=103, men 72%), prehypertension (PHT) (n=143, men 43%) and hypertension (HT) (n= 80, men 38%). There were no differences in age, salt intake, estimated glomerular filtration rate, sodium excretion and uromodulin among BP groups. However, in PHT subjects, uromodulin was positively associated with fractional sodium excretion and negatively with 24-h sodium excretion and diastolic BP dip. These findings point to the effect of uromodulin on sodium reabsorption along the nephron and consequently circadian BP alteration in prehypertensives., Promjene u dnevnom unosu kuhinjske soli u osoba osjetljivih na sol utječu na arterijski tlak (AT), ali točan patofiziološki mehanizam još nije u potpunosti razjašnjen. Cilj ove studije je bio istražiti izlučivanje uromodulina (UM) i natrija mokraćom i povezanost s AT u mlađih odraslih osoba. U 326 ispitanika (medijan dobi 36, IQR 18-48, 64,6% muškarci) analizirani su uzorci krvi i mokraće uzeti natašte i izmjeren je AT u ordinaciji, a kod 175 ispitanika učinjeno je kontinuirano mjerenje arterijskoga tlaka. UM je određen metodom ELISA. Prema klasifikaciji JNC-7 optimalni AT, predhipertenzija (PHT) i hipertenzija (HT) su dijagnosticirani u 103 (72% m), 143 (43% m) i 80 (38% m) ispitanika. Nije bilo razlike u dobi, unosu kuhinjske soli, procijenjenoj stopi glomerularne filtracije niti u izlučivanju natrija i UM mokraćom između kategorija AT. Uočena je pozitivna povezanost UM s frakcijskom ekskrecijom natrija, a negativna s 24-satnom natriurijom i noćnim sniženjem dijastoličkoga AT u PHT. Ovi rezultati upućuju na povezanost UM s tubularnom reapsorpcijom natrija i promjenama dnevnoga ritma AT u predhipertoničara.
Published: 2023

5. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

Author: Mancia, G, Kreutz, R, Brunström, M, Burnier, M, Grassi, G, Januszewicz, A, Muiesan, M, Tsioufis, K, Agabiti-Rosei, E, Algharably, E, Azizi, M, Benetos, A, Borghi, C, Hitij, J, Cifkova, R, Coca, A, Cornelissen, V, Cruickshank, J, Cunha, P, Danser, A, Pinho, R, Delles, C, Dominiczak, A, Dorobantu, M, Doumas, M, Fernández-Alfonso, M, Halimi, J, Járai, Z, Jelaković, B, Jordan, J, Kuznetsova, T, Laurent, S, Lovic, D, Lurbe, E, Mahfoud, F, Manolis, A, Miglinas, M, Narkiewicz, K, Niiranen, T, Palatini, P, Parati, G, Pathak, A, Persu, A, Polonia, J, Redon, J, Sarafidis, P, Schmieder, R, Spronck, B, Stabouli, S, Stergiou, G, Taddei, S, Thomopoulos, C, Tomaszewski, M, Van de Borne, P, Wanner, C, Weber, T, Williams, B, Zhang, Z, Kjeldsen, S, Mancia, Giuseppe, Kreutz, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Azizi, Michel, Benetos, Athanase, Borghi, Claudio, Hitij, Jana Brguljan, Cifkova, Renata, Coca, Antonio, Cornelissen, Veronique, Cruickshank, J Kennedy, Cunha, Pedro G, Danser, A H Jan, Pinho, Rosa Maria de, Delles, Christian, Dominiczak, Anna F, Dorobantu, Maria, Doumas, Michalis, Fernández-Alfonso, María S, Halimi, Jean-Michel, Járai, Zoltán, Jelaković, Bojan, Jordan, Jens, Kuznetsova, Tatiana, Laurent, Stephane, Lovic, Dragan, Lurbe, Empar, Mahfoud, Felix, Manolis, Athanasios, Miglinas, Marius, Narkiewicz, Krzystof, Niiranen, Teemu, Palatini, Paolo, Parati, Gianfranco, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Redon, Josep, Sarafidis, Pantelis, Schmieder, Roland, Spronck, Bart, Stabouli, Stella, Stergiou, George, Taddei, Stefano, Thomopoulos, Costas, Tomaszewski, Maciej, Van de Borne, Philippe, Wanner, Christoph, Weber, Thomas, Williams, Bryan, Zhang, Zhen-Yu, Kjeldsen, Sverre E, Mancia, G, Kreutz, R, Brunström, M, Burnier, M, Grassi, G, Januszewicz, A, Muiesan, M, Tsioufis, K, Agabiti-Rosei, E, Algharably, E, Azizi, M, Benetos, A, Borghi, C, Hitij, J, Cifkova, R, Coca, A, Cornelissen, V, Cruickshank, J, Cunha, P, Danser, A, Pinho, R, Delles, C, Dominiczak, A, Dorobantu, M, Doumas, M, Fernández-Alfonso, M, Halimi, J, Járai, Z, Jelaković, B, Jordan, J, Kuznetsova, T, Laurent, S, Lovic, D, Lurbe, E, Mahfoud, F, Manolis, A, Miglinas, M, Narkiewicz, K, Niiranen, T, Palatini, P, Parati, G, Pathak, A, Persu, A, Polonia, J, Redon, J, Sarafidis, P, Schmieder, R, Spronck, B, Stabouli, S, Stergiou, G, Taddei, S, Thomopoulos, C, Tomaszewski, M, Van de Borne, P, Wanner, C, Weber, T, Williams, B, Zhang, Z, Kjeldsen, S, Mancia, Giuseppe, Kreutz, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Azizi, Michel, Benetos, Athanase, Borghi, Claudio, Hitij, Jana Brguljan, Cifkova, Renata, Coca, Antonio, Cornelissen, Veronique, Cruickshank, J Kennedy, Cunha, Pedro G, Danser, A H Jan, Pinho, Rosa Maria de, Delles, Christian, Dominiczak, Anna F, Dorobantu, Maria, Doumas, Michalis, Fernández-Alfonso, María S, Halimi, Jean-Michel, Járai, Zoltán, Jelaković, Bojan, Jordan, Jens, Kuznetsova, Tatiana, Laurent, Stephane, Lovic, Dragan, Lurbe, Empar, Mahfoud, Felix, Manolis, Athanasios, Miglinas, Marius, Narkiewicz, Krzystof, Niiranen, Teemu, Palatini, Paolo, Parati, Gianfranco, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Redon, Josep, Sarafidis, Pantelis, Schmieder, Roland, Spronck, Bart, Stabouli, Stella, Stergiou, George, Taddei, Stefano, Thomopoulos, Costas, Tomaszewski, Maciej, Van de Borne, Philippe, Wanner, Christoph, Weber, Thomas, Williams, Bryan, Zhang, Zhen-Yu, and Kjeldsen, Sverre E
Abstract: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis (Greece), Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine (Turkey), Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering (Poland), Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos (Greece), Kazuomi Kario (Japan), Vasilios Kotsis (Greece), Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack (UK), Paolo Mulatero (Italy), Dike B. Ojji (Nigeria), Sungha Park (South Korea), Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz (Poland), Venkata Ram (India), Ramiro Sanchez (Argentina), Markus Schlaich (Australia), Alta Schutte (Australia), Cristina Sierra (Spain), Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios (Greece), Bruno Trimarco (Italy), Thomas Unger (The Netherlands), Bert-Jan van den Born (The Netherlands), Anna Vachulova (Slovak Republic), Agostino Virdis (Italy), Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton (USA), Jiri Widimsky (Czech Republic), Jacek Wolf (Poland), Grégoire Wuerzner (Switzerland), Eugene Yang (USA), Yuqing Zhang (China).
Published: 2023

6. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

Author: Mancia Chairperson, Giuseppe, Kreutz Co-Chair, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Azizi, Michel, Benetos, Athanase, Borghi, Claudio, Hitij, Jana Brguljan, Cifkova, Renata, Coca, Antonio, Cornelissen, Veronique, Cruickshank, Kennedy, Cunha, Pedro G, Danser, A H Jan, de Pinho, Rosa Maria, Delles, Christian, Dominiczak, Anna F, Dorobantu, Maria, Doumas, Michalis, Fernández-Alfonso, María S, Halimi, Jean-Michel, Járai, Zoltán, Jelaković, Bojan, Jordan, Jens, Kuznetsova, Tatiana, Laurent, Stephane, Lovic, Dragan, Lurbe, Empar, Mahfoud, Felix, Manolis, Athanasios, Miglinas, Marius, Narkiewicz, Krzystof, Niiranen, Teemu, Palatini, Paolo, Parati, Gianfranco, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Redon, Josep, Sarafidis, Pantelis, Schmieder, Roland, Spronck, Bart, Stabouli, Stella, Zhang, Zhen-Yu, Mancia Chairperson, Giuseppe, Kreutz Co-Chair, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Azizi, Michel, Benetos, Athanase, Borghi, Claudio, Hitij, Jana Brguljan, Cifkova, Renata, Coca, Antonio, Cornelissen, Veronique, Cruickshank, Kennedy, Cunha, Pedro G, Danser, A H Jan, de Pinho, Rosa Maria, Delles, Christian, Dominiczak, Anna F, Dorobantu, Maria, Doumas, Michalis, Fernández-Alfonso, María S, Halimi, Jean-Michel, Járai, Zoltán, Jelaković, Bojan, Jordan, Jens, Kuznetsova, Tatiana, Laurent, Stephane, Lovic, Dragan, Lurbe, Empar, Mahfoud, Felix, Manolis, Athanasios, Miglinas, Marius, Narkiewicz, Krzystof, Niiranen, Teemu, Palatini, Paolo, Parati, Gianfranco, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Redon, Josep, Sarafidis, Pantelis, Schmieder, Roland, Spronck, Bart, Stabouli, Stella, and Zhang, Zhen-Yu
Abstract: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis (Greece), Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine (Turkey), Claudio Ferri (Italy), Anthony Heagerty (UK), Slavomira Filipova (Slovak Republic), Michael Hecht Olsen (Denmark), Dagmara Hering (Poland), Uday Jadhav (India), Manolis Kallistratos (Greece), Kazuomi Kario (Japan), Vasilios Kotsis (Greece), Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack (UK), Paolo Mulatero (Italy), Dike B. Ojji (Nigeria), Sungha Park (South Korea), Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz (Poland), Venkata Ram (India), Ramiro Sanchez (Argentina), Markus Schlaich (Australia), Alta Schutte (Australia), Cristina Sierra (Spain), Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios (Greece), Bruno Trimarco (Italy), Thomas Unger (The Netherlands), Bert-Jan van den Born (The Netherlands), Anna Vachulova (Slovak Republic), Agostino Virdis (Italy), Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton (USA), Jiri Widimsky (Czech Republic), Jacek Wolf (Poland), Grégoire Wuerzner (Switzerland), Eugene Yang (USA), Yuqing Zhang (China).
Published: 2023

7. Preporuke za dijagnosticiranje, prevenciju i liječenje citomegalovirusa u bolesnika s presađenim solidnim organom

Author: Bašić-Jukić, Nikolina, Miličić, Davor, Samaržija, Miroslav, Jelaković, Bojan, Kaštelan, Željko, Bošnjak, Zrinka, Mareković, Ivana, Židovec Lepej, Snježana, Grgić, Ivana, Barbić, Jerko, Rački, Sanjin, Skorić, Boško, Čikeš, Maja, Džubur, Feđa, Merćep, Iveta, Prkačin, Ingrid, Maksimović, Bojana, Filipec Kanižaj, Tajana, Mrzljak, Anna, Furić-Čunko, Vesna, Katalinić, Lea, Fištrek-Prlić, Margareta, Sabljić, Zoran, Dika, Živka, Pavliša, Gordana, Radunović, Danilo, Prelević, Vladimir, Atić, Armin, Jurić, Ivana, Bašić-Jukić, Nikolina, Miličić, Davor, Samaržija, Miroslav, Jelaković, Bojan, Kaštelan, Željko, Bošnjak, Zrinka, Mareković, Ivana, Židovec Lepej, Snježana, Grgić, Ivana, Barbić, Jerko, Rački, Sanjin, Skorić, Boško, Čikeš, Maja, Džubur, Feđa, Merćep, Iveta, Prkačin, Ingrid, Maksimović, Bojana, Filipec Kanižaj, Tajana, Mrzljak, Anna, Furić-Čunko, Vesna, Katalinić, Lea, Fištrek-Prlić, Margareta, Sabljić, Zoran, Dika, Živka, Pavliša, Gordana, Radunović, Danilo, Prelević, Vladimir, Atić, Armin, and Jurić, Ivana
Abstract: Infekcija citomegalovirusom (CMV) još uvijek predstavlja jednu od najčešćih komplikacija u primatelja solidnih organa. Povezana je s povećanim rizikom različitih komplikacija, uključujući gubitak presatka i smrt primatelja. Multidisciplinarni panel stručnjaka koji se bave transplantacijom solidnih organa okupio se radi donošenja preporuka za dijagnostiku, prevenciju i liječenje CMV infekcije. Preporuke su prvenstveno posvećene suvremenom pristupu dijagnozi CMV infekcije, mogućnostima liječenja novim antivirusnim lijekovima i načinima liječenja rezistentne/refraktorne CMV bolesti., Cytomegalovirus (CMV) infection remains one of the most common complications in solid organ transplant recipients. It is associated with an increased risk of different complications, including graft loss and mortality. A multidisciplinary panel of solid organ transplant experts gathered to revise and adopt consensus recommendations on CMV diagnostics, prevention, and treatment. Recommendations focus on the current approach to diagnosing CMV infection, different methods of prevention, possibilities of treatment with novel antiviral therapies, and approaches to treating resistant/refractory disease.
Published: 2023

8. Estimated arterial stiffness and cardiovascular risk in chronic kidney disease – a study protocol

Author: Domislović, Marija, Brzić, Ivan, Radunović, Danilo, Prelević, Vladimir, Jelaković, Bojan, Domislović, Marija, Brzić, Ivan, Radunović, Danilo, Prelević, Vladimir, and Jelaković, Bojan
Abstract: Introduction The prevalence of chronic kidney disease (CKD) in the general population is 9.1%. Cur- rent guidelines recommend a cut-off GFR value of 60 mL/min/1.73 m2 for diagnosis of CKD, without considering the physiological decline of GFR with aging, or the association with cardiovascular (CV), cerebrovascular or renal outcomes. There is also an increase in arterial stiffness with aging, which is es- timated by pulse wave velocity (PWV). Aim The aim of this study is to show how the ePWV predicts CV incidents independently of SCORE chart and traditional risk factors. Materials and Methods This prospective observational study will include 2058 subjects from the Endemic nephropathy in Croatia – epidemiology, diagnosis and etiopathogenesis scientific research project. Conclusion This will be the first study that could show how the estimated arterial stiffness, independently of CKD contributes to overall CV, cerebrovascular and renal risk. We could also, based on the results, propose an age-independent definition of CKD based on the association with CV disease and mortality.
Published: 2022

9. Climate changes and arterial hypertension – global risk. Environmental hypertensiology

Author: Jelaković, Bojan and Jelaković, Bojan
Published: 2022

10. Chronic Kidney Disease in Rural Population

Author: Domislović, Marija, Domislović, Viktor, Stevanović, Ranko, Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Kos, Jelena, Jelaković, Ana, Premužić, Vedran, Leko, Ninoslav, Josipović, Josipa, Brzić, Ivan, Željković Vrkić, Tajana, Capak, Krunoslav, Jelaković, Bojan, Domislović, Marija, Domislović, Viktor, Stevanović, Ranko, Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Kos, Jelena, Jelaković, Ana, Premužić, Vedran, Leko, Ninoslav, Josipović, Josipa, Brzić, Ivan, Željković Vrkić, Tajana, Capak, Krunoslav, and Jelaković, Bojan
Abstract: The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the KDIGO guidelines. The overall prevalence of CKD (eGFR <60 mL/min/1.73 m2) was 8.83% (F vs. M 9.9% vs. 6.3%; p<0.001). Albuminuria (albumin-to-creatinine ratio >30 mg/g) was found in 8.45% (F vs. M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in subjects older than 65 years; F vs. M 30.9% vs. 26.8%; p<0.01). The strongest predictor factors for CKD were age >65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose >7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41). In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a significant independent predictor of CKD., Cilj ove studije bio je istražiti učestalost kronične bubrežne bolesti (KBB) kod seoskog stanovništva i analizirati povezanost s čimbenicima kardiovaskularnoga rizika i starenjem. U studiju je bilo uključeno 2193 ispitanika (1333 žena, 860 muškaraca, srednja dob 50,61±17,12 godina). Svi ispitanici su ispunili opsežan upitnik i klinički su pregledani. Uzet im je uzorak krvi natašte i drugi jutarnji uzorak mokraće. Procijenjena stopa glomerularne filtracije (eGFR) utvrđena je pomoću jednadžbe CKD-EPI. Ispitanici su klasificirani prema smjernicama KDIGO. Sveukupna učestalost KBB (eGFR <60 mL/ min/1,73 m2) bila je 8,83% (žene prema muškarcima 9,9% prema 6,3%; p<0,001). Albuminurija je potvrđena (omjer albumina i kreatinina (ACR) >30 mg/g) u 8,45% ispitanika bez razlike među spolovima. Učestalost KBB bila je značajno veća kod ispitanika starijih od 65 godina u oba spola (29,44%; žene prema muškarcima 30,9% prema 26,6%; p<0,01). Najjači prediktorski čimbenici za KBB bili su dob >65 godina (OR 22,12), hipertenzija (OR 6,53), albuminurija (OR 5,71), glukoza u krvi natašte >7 mmol/L (OR 5,49), dijabetes (OR 3,07), trbušna pretilost (OR 2,05) i nepušenje (OR 0,41). U multivarijatnoj analizi (OR 1,13) su ženski spol (OR 0,60) i dijabetes (OR 1,75) bili nezavisni prediktorski čimbenici za KBB. U zaključku, učestalost KBB je velika u ruralnoj populaciji. U oba spola eGFR se značajno smanjila starenjem, koje se pokazalo kao značajan nezavisni prediktor za KBB.
Published: 2022

11. Environmental hypertensiology – the effects of seasonal changes on blood pressure and global risk

Author: Srnec, Lidija, Jelaković, Bojan, Srnec, Lidija, and Jelaković, Bojan
Published: 2022

12. Prevalence of incidental chronic kidney disease and patient characteristics - results of the EH-UH 2 study and the ENAH project

Author: Domislović, Marija, Gellineo, Lana, Jelaković, Ana, Dika, Živka, Domislović, Viktor, Đapić, Krešimir, Karanović, Sandra, Vuković Brinar, Ivana, Bukal, Nikolina, Abramović Barić, Mirta, Brzić, Ivan, Jelaković, Bojan, Domislović, Marija, Gellineo, Lana, Jelaković, Ana, Dika, Živka, Domislović, Viktor, Đapić, Krešimir, Karanović, Sandra, Vuković Brinar, Ivana, Bukal, Nikolina, Abramović Barić, Mirta, Brzić, Ivan, and Jelaković, Bojan
Abstract: Introduction: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular (CV) disease and premature deaths. The worldwide prevalence of CKD in 2017 in the general population is 9.1%. In this paper our primary aim was to present preliminary data on incidental, i.e., newly discov- ered CKD and the overall prevalence of CKD in the adult population in Croatia. Secondary aim was to compare these data with the data of the CKD prevalence of the adult population from the rural part of Croatia (results of the ENAH study). Materials and Methods: This cross-sectional observational study included random, representative sample of general adults in Croatia, 781 subjects who were part of the large cohort from the EH-UH 2 study. The eGFR was calculated by creatinine-based CKD EPI equation. Albuminuria was determined from the albumin to creatinine ratio in urine (ACR) in 691 subjects. Results: The overall prevalence of CKD in Croatia was 12.7%, of which 9.5% were newly discovered CKD, and only 3.2% were subjects with previously known CKD. According to the albuminuria level, 30.7% of the adult population belonged to the group with a moderate risk of CKD progression, and 7% had a high risk, while 2.5% of the study subjects had a very high risk. Predictors for newly discov- ered CKD are older age, higher urate and potassium, antihypertensive therapy, angina pectoris, atrial fibrillation, lower hemoglobin level. Conclusions: These results continue in a pilot project of the Croatian Kidney Society and the Croatian Hypertension League on the implementation of an action plan to detect new kidney disease in the general population in real life, in a collaboration of primary care physicians and nephrologists.
Published: 2022

13. Aristolochic acid Nephropathy and Balkan Nephropathy

Author: Nortier, Joëlle, Vanherweghem, Jean-Louis, Jelaković, Bojan, Nortier, Joëlle, Vanherweghem, Jean-Louis, and Jelaković, Bojan
Abstract: info:eu-repo/semantics/published
Published: 2022

14. Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: Consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient

Author: Kotsis, V, Jordan, J, Stabouli, S, Antza, C, Micic, D, Jelaković, B, Schlaich, M, Nilsson, P, Kreutz, R, Mancia, G, Tsioufis, K, Grassi, G, Kotsis, Vasilios, Jordan, Jens, Stabouli, Stella, Antza, Christina, Micic, Dragan, Jelaković, Bojan, Schlaich, Markus P, Nilsson, Peter M, Kreutz, Reinhold, Mancia, Giuseppe, Tsioufis, Kostas, Grassi, Guido, Kotsis, V, Jordan, J, Stabouli, S, Antza, C, Micic, D, Jelaković, B, Schlaich, M, Nilsson, P, Kreutz, R, Mancia, G, Tsioufis, K, Grassi, G, Kotsis, Vasilios, Jordan, Jens, Stabouli, Stella, Antza, Christina, Micic, Dragan, Jelaković, Bojan, Schlaich, Markus P, Nilsson, Peter M, Kreutz, Reinhold, Mancia, Giuseppe, Tsioufis, Kostas, and Grassi, Guido
Abstract: The prevalence of type 2 diabetes (T2D) has increased over the past few decades. T2D has a strong genetic propensity that becomes overt when a patient is exposed to a typical Western lifestyle, gain weight and becomes obese, whereas weight loss protects from the development of T2D. Except of lifestyle modifications, the choice of the appropriate treatment is essential in the management of patients with T2D and appears critical for the obese population with T2D. The new pharmacological approach for the treatment of T2D, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists, seems to be effective not only in the management of T2D but also for weight loss, reduction of blood pressure and improvement of nonalcoholic fatty liver disease. Sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 analogues reduced cardiovascular risk, prevented cardiovascular disease and mortality, thereby playing an important role in the treatment of obese patients with hypertension and T2D.
Published: 2020

15. Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid

Author: Jelaković, Bojan, Dika, Živka, Arlt, Volker V.M., Stiborova, Marie, Pavlović, Nikola N.M., Nikolić, Jovan, Colet, Jean-Marie, Vanherweghem, Jean-Louis, Nortier, Joëlle, Jelaković, Bojan, Dika, Živka, Arlt, Volker V.M., Stiborova, Marie, Pavlović, Nikola N.M., Nikolić, Jovan, Colet, Jean-Marie, Vanherweghem, Jean-Louis, and Nortier, Joëlle
Abstract: Summary: Balkan endemic nephropathy is a chronic tubulointerstitial disease with insidious onset, slowly progressing to end-stage renal disease and frequently associated with urothelial carcinoma of the upper urinary tract (UTUC). It was described in South-East Europe at the Balkan peninsula in rural areas around tributaries of the Danube River. After decades of intensive investigation, the causative factor was identified as the environmental phytotoxin aristolochic acid (AA)contained in Aristolochia clematitis, a common plant growing in wheat fields that was ingested through home-baked bread. AA initially was involved in the outbreak of cases of rapidly progressive renal fibrosis reported in Belgium after intake of root extracts of Aristolochia fangchi imported from China. A high prevalence of UTUC was found in these patients. The common molecular link between Balkan and Belgian nephropathy cases was the detection of aristolactam-DNA adducts in renal tissue and UTUC. These adducts are not only biomarkers of prior exposure to AA, but they also trigger urothelial malignancy by inducing specific mutations (A:T to T:A transversion)in critical genes of carcinogenesis, including the tumor-suppressor TP53. Such mutational signatures are found in other cases worldwide, particularly in Taiwan, highlighting the general public health issue of AA exposure by traditional phytotherapies., SCOPUS: re.j, info:eu-repo/semantics/published
Published: 2019

16. MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol

Author: Parati, G, Agabiti-Rosei, E, Bakris, G, Bilo, G, Branzi, G, Cecchi, F, Chrostowska, M, De la Sierra, A, Domenech, M, Dorobantu, M, Faria, T, Huo, Y, Jelaković, B, Kahan, T, Konradi, A, Laurent, S, Li, N, Madan, K, Mancia, G, Mcmanus, R, Modesti, P, Ochoa, J, Octavio, J, Omboni, S, Palatini, P, Park, J, Pellegrini, D, Perl, S, Podoleanu, C, Pucci, G, Redon, J, Renna, N, Rhee, M, Rodilla Sala, E, Sanchez, R, Schmieder, R, Soranna, D, Stergiou, G, Stojanovic, M, Tsioufis, K, Valsecchi, M, Veglio, F, Waisman, G, Wang, J, Wijnmaalen, P, Zambon, A, Zanchetti, A, Zhang, Y, Parati, Gianfranco, Agabiti-Rosei, Enrico, Bakris, George L, Bilo, Grzegorz, Branzi, Giovanna, Cecchi, Franco, Chrostowska, Marzena, De la Sierra, Alejandro, Domenech, Monica, Dorobantu, Maria, Faria, Thays, Huo, Yong, Jelaković, Bojan, Kahan, Thomas, Konradi, Alexandra, Laurent, Stéphane, Li, Nanfang, Madan, Kushal, Mancia, Giuseppe, McManus, Richard J, Modesti, Pietro Amedeo, Ochoa, Juan Eugenio, Octavio, José Andrés, Omboni, Stefano, Palatini, Paolo, Park, Jeong Bae, Pellegrini, Dario, Perl, Sabine, Podoleanu, Cristian, Pucci, Giacomo, Redon, Josep, Renna, Nicolas, Rhee, Moo Yong, Rodilla Sala, Enrique, Sanchez, Ramiro, Schmieder, Roland, Soranna, Davide, Stergiou, George, Stojanovic, Milos, Tsioufis, Konstantinos, Valsecchi, Maria Grazia, Veglio, Franco, Waisman, Gabriel Dario, Wang, Ji Guang, Wijnmaalen, Paulina, Zambon, Antonella, Zanchetti, Alberto, Zhang, Yuqing, Parati, G, Agabiti-Rosei, E, Bakris, G, Bilo, G, Branzi, G, Cecchi, F, Chrostowska, M, De la Sierra, A, Domenech, M, Dorobantu, M, Faria, T, Huo, Y, Jelaković, B, Kahan, T, Konradi, A, Laurent, S, Li, N, Madan, K, Mancia, G, Mcmanus, R, Modesti, P, Ochoa, J, Octavio, J, Omboni, S, Palatini, P, Park, J, Pellegrini, D, Perl, S, Podoleanu, C, Pucci, G, Redon, J, Renna, N, Rhee, M, Rodilla Sala, E, Sanchez, R, Schmieder, R, Soranna, D, Stergiou, G, Stojanovic, M, Tsioufis, K, Valsecchi, M, Veglio, F, Waisman, G, Wang, J, Wijnmaalen, P, Zambon, A, Zanchetti, A, Zhang, Y, Parati, Gianfranco, Agabiti-Rosei, Enrico, Bakris, George L, Bilo, Grzegorz, Branzi, Giovanna, Cecchi, Franco, Chrostowska, Marzena, De la Sierra, Alejandro, Domenech, Monica, Dorobantu, Maria, Faria, Thays, Huo, Yong, Jelaković, Bojan, Kahan, Thomas, Konradi, Alexandra, Laurent, Stéphane, Li, Nanfang, Madan, Kushal, Mancia, Giuseppe, McManus, Richard J, Modesti, Pietro Amedeo, Ochoa, Juan Eugenio, Octavio, José Andrés, Omboni, Stefano, Palatini, Paolo, Park, Jeong Bae, Pellegrini, Dario, Perl, Sabine, Podoleanu, Cristian, Pucci, Giacomo, Redon, Josep, Renna, Nicolas, Rhee, Moo Yong, Rodilla Sala, Enrique, Sanchez, Ramiro, Schmieder, Roland, Soranna, Davide, Stergiou, George, Stojanovic, Milos, Tsioufis, Konstantinos, Valsecchi, Maria Grazia, Veglio, Franco, Waisman, Gabriel Dario, Wang, Ji Guang, Wijnmaalen, Paulina, Zambon, Antonella, Zanchetti, Alberto, and Zhang, Yuqing
Abstract: Introduction Masked uncontrolled hypertension (MUCH) carries an increased risk of cardiovascular (CV) complications and can be identified through combined use of office (O) and ambulatory (A) blood pressure (BP) monitoring (M) in treated patients. However, it is still debated whether the information carried by ABPM should be considered for MUCH management. Aim of the MASked-unconTrolled hypERtension management based on OBP or on ambulatory blood pressure measurement (MASTER) Study is to assess the impact on outcome of MUCH management based on OBPM or ABPM. Methods and analysis MASTER is a 4-year prospective, randomised, open-label, blinded-endpoint investigation. A total of 1240 treated hypertensive patients from about 40 secondary care clinical centres worldwide will be included -upon confirming presence of MUCH (repeated on treatment OBP <140/90 mm Hg, and at least one of the following: Daytime ABP ≥135/85 mm Hg; night-time ABP ≥120/70 mm Hg; 24 hour ABP ≥130/80 mm Hg), and will be randomised to a management strategy based on OBPM (group 1) or on ABPM (group 2). Patients in group 1 will have OBP measured at 0, 3, 6, 12, 18, 24, 30, 36, 42 and 48 months and taken as a guide for treatment; ABPM will be performed at randomisation and at 12, 24, 36 and 48 months but will not be used to take treatment decisions. Patients randomised to group 2 will have ABPM performed at randomisation and all scheduled visits as a guide to antihypertensive treatment. The effects of MUCH management strategy based on ABPM or on OBPM on CV and renal intermediate outcomes (changing left ventricular mass and microalbuminuria, coprimary outcomes) at 1 year and on CV events at 4 years and on changes in BP-related variables will be assessed. Ethics and dissemination MASTER study protocol has received approval by the ethical review board of Istituto Auxologico Italiano. The procedures set out in this protocol are in accordance with principles of Declaration of Helsinki and Good Clinical Practice
Published: 2018

17. MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol

Author: Parati, G, Agabiti-Rosei, E, Bakris, G, Bilo, G, Branzi, G, Cecchi, F, Chrostowska, M, De la Sierra, A, Domenech, M, Dorobantu, M, Faria, T, Huo, Y, Jelaković, B, Kahan, T, Konradi, A, Laurent, S, Li, N, Madan, K, Mancia, G, Mcmanus, R, Modesti, P, Ochoa, J, Octavio, J, Omboni, S, Palatini, P, Park, J, Pellegrini, D, Perl, S, Podoleanu, C, Pucci, G, Redon, J, Renna, N, Rhee, M, Rodilla Sala, E, Sanchez, R, Schmieder, R, Soranna, D, Stergiou, G, Stojanovic, M, Tsioufis, K, Valsecchi, M, Veglio, F, Waisman, G, Wang, J, Wijnmaalen, P, Zambon, A, Zanchetti, A, Zhang, Y, Parati, Gianfranco, Agabiti-Rosei, Enrico, Bakris, George L, Bilo, Grzegorz, Branzi, Giovanna, Cecchi, Franco, Chrostowska, Marzena, De la Sierra, Alejandro, Domenech, Monica, Dorobantu, Maria, Faria, Thays, Huo, Yong, Jelaković, Bojan, Kahan, Thomas, Konradi, Alexandra, Laurent, Stéphane, Li, Nanfang, Madan, Kushal, Mancia, Giuseppe, McManus, Richard J, Modesti, Pietro Amedeo, Ochoa, Juan Eugenio, Octavio, José Andrés, Omboni, Stefano, Palatini, Paolo, Park, Jeong Bae, Pellegrini, Dario, Perl, Sabine, Podoleanu, Cristian, Pucci, Giacomo, Redon, Josep, Renna, Nicolas, Rhee, Moo Yong, Rodilla Sala, Enrique, Sanchez, Ramiro, Schmieder, Roland, Soranna, Davide, Stergiou, George, Stojanovic, Milos, Tsioufis, Konstantinos, Valsecchi, Maria Grazia, Veglio, Franco, Waisman, Gabriel Dario, Wang, Ji Guang, Wijnmaalen, Paulina, Zambon, Antonella, Zanchetti, Alberto, Zhang, Yuqing, Parati, G, Agabiti-Rosei, E, Bakris, G, Bilo, G, Branzi, G, Cecchi, F, Chrostowska, M, De la Sierra, A, Domenech, M, Dorobantu, M, Faria, T, Huo, Y, Jelaković, B, Kahan, T, Konradi, A, Laurent, S, Li, N, Madan, K, Mancia, G, Mcmanus, R, Modesti, P, Ochoa, J, Octavio, J, Omboni, S, Palatini, P, Park, J, Pellegrini, D, Perl, S, Podoleanu, C, Pucci, G, Redon, J, Renna, N, Rhee, M, Rodilla Sala, E, Sanchez, R, Schmieder, R, Soranna, D, Stergiou, G, Stojanovic, M, Tsioufis, K, Valsecchi, M, Veglio, F, Waisman, G, Wang, J, Wijnmaalen, P, Zambon, A, Zanchetti, A, Zhang, Y, Parati, Gianfranco, Agabiti-Rosei, Enrico, Bakris, George L, Bilo, Grzegorz, Branzi, Giovanna, Cecchi, Franco, Chrostowska, Marzena, De la Sierra, Alejandro, Domenech, Monica, Dorobantu, Maria, Faria, Thays, Huo, Yong, Jelaković, Bojan, Kahan, Thomas, Konradi, Alexandra, Laurent, Stéphane, Li, Nanfang, Madan, Kushal, Mancia, Giuseppe, McManus, Richard J, Modesti, Pietro Amedeo, Ochoa, Juan Eugenio, Octavio, José Andrés, Omboni, Stefano, Palatini, Paolo, Park, Jeong Bae, Pellegrini, Dario, Perl, Sabine, Podoleanu, Cristian, Pucci, Giacomo, Redon, Josep, Renna, Nicolas, Rhee, Moo Yong, Rodilla Sala, Enrique, Sanchez, Ramiro, Schmieder, Roland, Soranna, Davide, Stergiou, George, Stojanovic, Milos, Tsioufis, Konstantinos, Valsecchi, Maria Grazia, Veglio, Franco, Waisman, Gabriel Dario, Wang, Ji Guang, Wijnmaalen, Paulina, Zambon, Antonella, Zanchetti, Alberto, and Zhang, Yuqing
Abstract: Introduction Masked uncontrolled hypertension (MUCH) carries an increased risk of cardiovascular (CV) complications and can be identified through combined use of office (O) and ambulatory (A) blood pressure (BP) monitoring (M) in treated patients. However, it is still debated whether the information carried by ABPM should be considered for MUCH management. Aim of the MASked-unconTrolled hypERtension management based on OBP or on ambulatory blood pressure measurement (MASTER) Study is to assess the impact on outcome of MUCH management based on OBPM or ABPM. Methods and analysis MASTER is a 4-year prospective, randomised, open-label, blinded-endpoint investigation. A total of 1240 treated hypertensive patients from about 40 secondary care clinical centres worldwide will be included -upon confirming presence of MUCH (repeated on treatment OBP <140/90 mm Hg, and at least one of the following: Daytime ABP ≥135/85 mm Hg; night-time ABP ≥120/70 mm Hg; 24 hour ABP ≥130/80 mm Hg), and will be randomised to a management strategy based on OBPM (group 1) or on ABPM (group 2). Patients in group 1 will have OBP measured at 0, 3, 6, 12, 18, 24, 30, 36, 42 and 48 months and taken as a guide for treatment; ABPM will be performed at randomisation and at 12, 24, 36 and 48 months but will not be used to take treatment decisions. Patients randomised to group 2 will have ABPM performed at randomisation and all scheduled visits as a guide to antihypertensive treatment. The effects of MUCH management strategy based on ABPM or on OBPM on CV and renal intermediate outcomes (changing left ventricular mass and microalbuminuria, coprimary outcomes) at 1 year and on CV events at 4 years and on changes in BP-related variables will be assessed. Ethics and dissemination MASTER study protocol has received approval by the ethical review board of Istituto Auxologico Italiano. The procedures set out in this protocol are in accordance with principles of Declaration of Helsinki and Good Clinical Practice
Published: 2018

18. Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy.

Author: Jelaković, Bojan, Jelaković, Bojan, Nikolić, Jovan, Radovanović, Zoran, Nortier, Joelle, Cosyns, Jean-Pierre, Grollman, Arthur P, Bašić-Jukić, Nikolina, Belicza, Mladen, Bukvić, Danica, Čavaljuga, Semra, Čvorišćec, Dubravka, Cvitković, Ante, Dika, Živka, Dimitrov, Plamen, Đukanović, Ljubica, Edwards, Karen, Ferluga, Dušan, Fuštar-Preradović, Ljubica, Gluhovschi, Gheorghe, Imamović, Goran, Jakovina, Tratinčica, Kes, Petar, Leko, Ninoslav, Medverec, Zvonimir, Mesić, Enisa, Miletić-Medved, Marica, Miller, Frederick, Pavlović, Nikola, Pasini, Josip, Pleština, Stjepko, Polenaković, Momir, Stefanović, Vladislav, Tomić, Karla, Trnačević, Senaid, Vuković Lela, Ivana, Štern-Padovan, Ranka, Jelaković, Bojan, Jelaković, Bojan, Nikolić, Jovan, Radovanović, Zoran, Nortier, Joelle, Cosyns, Jean-Pierre, Grollman, Arthur P, Bašić-Jukić, Nikolina, Belicza, Mladen, Bukvić, Danica, Čavaljuga, Semra, Čvorišćec, Dubravka, Cvitković, Ante, Dika, Živka, Dimitrov, Plamen, Đukanović, Ljubica, Edwards, Karen, Ferluga, Dušan, Fuštar-Preradović, Ljubica, Gluhovschi, Gheorghe, Imamović, Goran, Jakovina, Tratinčica, Kes, Petar, Leko, Ninoslav, Medverec, Zvonimir, Mesić, Enisa, Miletić-Medved, Marica, Miller, Frederick, Pavlović, Nikola, Pasini, Josip, Pleština, Stjepko, Polenaković, Momir, Stefanović, Vladislav, Tomić, Karla, Trnačević, Senaid, Vuković Lela, Ivana, and Štern-Padovan, Ranka
Abstract: Currently used diagnostic criteria in different endemic (Balkan) nephropathy (EN) centers involve different combinations of parameters, various cut-off values and many of them are not in agreement with proposed international guidelines. Leaders of EN centers began to address these problems at scientific meetings, and this paper is the outgrowth of those discussions. The main aim is to provide recommendations for clinical work on current knowledge and expertise. This document is developed for use by general physicians, nephrologists, urologist, public health experts and epidemiologist, and it is hoped that it will be adopted by responsible institutions in countries harboring EN. National medical providers should cover costs of screening and diagnostic procedures and treatment of EN patients with or without upper urothelial cancers.
Published: 2014

19. Metabonomics: On the road to detect diagnostic biomarkers in endemic (Balkan) nephropathy. evaluation in a retrospective pilot project

Author: Duquesne, M., Goossens, C., Dika, Živka, Conotte, Raphaël, Nortier, Joëlle, Jelaković, Bojan, Colet, Jean-Marie, Duquesne, M., Goossens, C., Dika, Živka, Conotte, Raphaël, Nortier, Joëlle, Jelaković, Bojan, and Colet, Jean-Marie
Abstract: Introduction: Endemic (Balkan) Nephropathy is a chronic renal disease mainly affecting rural populations in the valleys of the Danube. In the absence of renal replacement therapy, it leads to fatal kidney failure and is significantly associated with upper urothelial carcinoma. Bread poisoning with aristolochic acids is now widely accepted. The source of this toxic substance is considered to be Aristolochia clematitis, a perennial plant that invades farming fields. The poisoning with aristolochic acids was suggested when clinical and histopathological changes similar to those observed in the Balkan patients were reported in several cases of nephropathy in Belgian patients unintentionally exposed to aristolochic acids during a Chinese herbs diet. Those clinical and histopathological features were then reproduced in laboratory experimental models. Methods: Using metabonomics, an emerging dynamic technique that allows an effective mapping of alterations in endogenous metabolites levels in biofluids and tissues, we evaluated early signs of renal toxicity from extra urine samples collected in a rat model of intoxication with aristolochic acids. Results: Changes in urine composition were consistent with a proximal tubular damage, most likely initiated by a mitochondrial default and an inappropriate response to oxidative stress. The same metabonomic approach was applied to surplus of urine samples collected from Belgian and Croatian patients in clinical and epidemiological studies, respectively. It allowed a clear discrimination of the Belgian patients from a database of healthy volunteers. On the other hand, a trend to discrimination was noticed when comparing urine samples collected from individuals living in Croatian endemic regions as compared to Croatian non endemic villages. Finally, when included in the same analysis, both Belgian and Croatian patients displayed similar urine metabolic signatures, suggesting a common etiology of both diseases. © 2012 Duquesne M, et a, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2013

20. Metabonomics: On the road to detect diagnostic biomarkers in endemic (Balkan) nephropathy. evaluation in a retrospective pilot project

Author: Duquesne, M., Goossens, C., Dika, Živka, Conotte, Raphaël, Nortier, Joëlle, Jelaković, Bojan, Colet, Jean-Marie, Duquesne, M., Goossens, C., Dika, Živka, Conotte, Raphaël, Nortier, Joëlle, Jelaković, Bojan, and Colet, Jean-Marie
Abstract: Introduction: Endemic (Balkan) Nephropathy is a chronic renal disease mainly affecting rural populations in the valleys of the Danube. In the absence of renal replacement therapy, it leads to fatal kidney failure and is significantly associated with upper urothelial carcinoma. Bread poisoning with aristolochic acids is now widely accepted. The source of this toxic substance is considered to be Aristolochia clematitis, a perennial plant that invades farming fields. The poisoning with aristolochic acids was suggested when clinical and histopathological changes similar to those observed in the Balkan patients were reported in several cases of nephropathy in Belgian patients unintentionally exposed to aristolochic acids during a Chinese herbs diet. Those clinical and histopathological features were then reproduced in laboratory experimental models. Methods: Using metabonomics, an emerging dynamic technique that allows an effective mapping of alterations in endogenous metabolites levels in biofluids and tissues, we evaluated early signs of renal toxicity from extra urine samples collected in a rat model of intoxication with aristolochic acids. Results: Changes in urine composition were consistent with a proximal tubular damage, most likely initiated by a mitochondrial default and an inappropriate response to oxidative stress. The same metabonomic approach was applied to surplus of urine samples collected from Belgian and Croatian patients in clinical and epidemiological studies, respectively. It allowed a clear discrimination of the Belgian patients from a database of healthy volunteers. On the other hand, a trend to discrimination was noticed when comparing urine samples collected from individuals living in Croatian endemic regions as compared to Croatian non endemic villages. Finally, when included in the same analysis, both Belgian and Croatian patients displayed similar urine metabolic signatures, suggesting a common etiology of both diseases. © 2012 Duquesne M, et a, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2013

21. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

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Fariba, Ahmed, Soheir H, Ahrens, Wolfgang, Ajlouni, Kamel, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Aly, Eman, Amarapurkar, Deepak N, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Ansong, Daniel, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assunção, Maria Cecília F, Auvinen, Juha, Avdićová, Mária, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Bahijri, Suhad, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Banadinović, Maja, Bandosz, Piotr, Banegas, José R, Baran, Joanna, Barbagallo, Carlo M, Barceló, Alberto, Barkat, Amina, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, 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Andrzej, Palli, Domenico, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Panza, Francesco, Paoli, Mariela, Papandreou, Dimitrios, Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R, Parsaeian, Mahboubeh, Pasquet, Patrick, Patel, Nikhil D, Pavlyshyn, Halyna, Pećin, Ivan, Pednekar, Mangesh S, Pedro, João M, Peer, Nasheeta, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peres, Karen GDA, Peres, Marco A, Peters, Annette, Petkeviciene, Janina, Peykari, Niloofar, Pham, Son Thai, Pichardo, Rafael N, Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia n, Plans-Rubió, Pedro, Polašek, Ozren, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J, Price, Jacqueline F, Providencia, Rui, Puhakka, Soile E, Puiu, Maria, Punab, Margus, Qasrawi, Radwan F, Qorbani, Mostafa, Queiroz, Daniel, Quoc Bao, Tran, Radić, Ivana, Radisauskas, Ricardas, Rahimikazerooni, Salar, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Rakhimova, Ellina M, Ramachandra Rao, Sudha, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Lekhraj, Rampal, Sanjay, Rangel Reina, Daniel A, Rarra, Vayia, Rech, Cassiano Ricardo, Redon, Josep, Reganit, Paul Ferdinand M, Regecová, Valéria, Revilla, Luis, Rezaianzadeh, Abbas, Ribeiro, Robespierre, Riboli, Elio, Richter, Adrian, Rigo, Fernando, Rinke de Wit, Tobias F, Ritti-Dias, Raphael M, Robitaille, Cynthia, Rodríguez-Artalejo, Fernando, Rodriguez-Perez, María del Cristo, Rodríguez-Villamizar, Laura A, Roggenbuck, Ulla, Rojas-Martinez, Rosalba, Romaguera, Dora, Romeo, Elisabetta L, Rosengren, Annika, Roy, Joel GR, Rubinstein, Adolfo, Ruidavets, Jean-Bernard, Ruiz-Betancourt, Blanca Sandra, Ruiz-Castell, Maria, Rusakova, Iuliia A, Russo, Paola, Rutkowski, Marcin, Sabanayagam, Charumathi, Sabbaghi, Hamideh, Sachdev, Harshpal S, Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saidi, Olfa, Sakarya, Sibel, Saki, Nader, Salanave, Benoit, Salazar Martinez, Eduardo, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sánchez-Abanto, Jose, Sans, Susana, Santos, Diana A, Santos, Ina S, Santos, Lèlita C, Santos, Maria Paula, Santos, Rute, Saramies, Jouko L, Sardinha, Luis B, Sarganas, Giselle, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schargrodsky, Herman, Schipf, Sabine, Schmidt, Carsten O, Schnohr, Peter, Schöttker, Ben, Schramm, Sara, Schultsz, Constance, Schutte, Aletta E, Sebert, Sylvain, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Servais, Jennifer, Shalnova, Svetlana A, Shamah-Levy, Teresa, Shamshirgaran, Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shin, Dong Wook, Shirani, Majid, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobngwi, Eugène, Söderberg, Stefan, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sorić, Maroje, Sossa Jérome, Charles, Soumaré, Aïcha, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Staessen, Jan A, Starc, Gregor, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Doris, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Suka, Machi, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G, Syddall, Holly E, 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Christophe, Ueda, Peter, Ugel, Eunice, Ulmer, Hanno, Uusitalo, Hannu MT, Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, van Zutphen, Elisabeth M, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Vasan, Senthil K, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, WM Monique, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Villalpando, Salvador, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Voutilainen, Ari, Wade, Alisha N, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H, Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Emmanuel A, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Tien Yin, Woo, Jean, Wu, Frederick C, Wu, Shouling, Wyszynska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K, Yoosefi, Moein, Yoshihara, Akihiro, You, San-Lin, Younger-Coleman, Novie O, Yusoff, Ahmad Faudzi, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zapata, Maria Elisa, Zaw, Ko Ko, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhen, Shiqi, Zheng, Yingfeng, Zholdin, Bekbolat, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, and Ezzati, Majid
Abstract: Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of
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21 results on '"JELAKOVIĆ, BOJAN"'

1. Smjernice za dijagnostiku i liječenje odraslih bolesnika s Fabryjevom bolesti

2. Warsaw communiqué on climate change in Europe

3. Prevalence of prediabetes and risk factors in the general adult population of Croatia - EH-UH 2 study

4. Uromodulin – a Link between Sodium Excretion and Alteration in Circadian Blood Pressure Pattern in Prehypertensives

5. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

6. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

7. Preporuke za dijagnosticiranje, prevenciju i liječenje citomegalovirusa u bolesnika s presađenim solidnim organom

8. Estimated arterial stiffness and cardiovascular risk in chronic kidney disease – a study protocol

9. Climate changes and arterial hypertension – global risk. Environmental hypertensiology

10. Chronic Kidney Disease in Rural Population

11. Environmental hypertensiology – the effects of seasonal changes on blood pressure and global risk

12. Prevalence of incidental chronic kidney disease and patient characteristics - results of the EH-UH 2 study and the ENAH project

13. Aristolochic acid Nephropathy and Balkan Nephropathy

14. Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: Consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient

15. Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid

16. MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol

17. MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol

18. Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy.

19. Metabonomics: On the road to detect diagnostic biomarkers in endemic (Balkan) nephropathy. evaluation in a retrospective pilot project

20. Metabonomics: On the road to detect diagnostic biomarkers in endemic (Balkan) nephropathy. evaluation in a retrospective pilot project

21. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

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21 results on '"JELAKOVIĆ, BOJAN"'

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