4 results on '"Immune phenotypes"'
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2. Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients
- Author
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Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, Instituto de Salud Carlos III, Toscano-Guerra, Emily, Martínez-Gallo, Mónica, Arrese-Muñoz, Iria, Gine, Anna, Diaz, Noelia, Gabriel-Medina, Pablo, Riveiro-Barciela, Mar, Labrador-Horrillo, Moisés, Martínez-Valle, Fernando, Sánchez Montalvá, Adrián, Hernández-González, Manuel, Pujol Borrell, Ricardo, Rodríguez-Frías, Francisco, Ferrer, Roser, Thomson, Timothy M., Paciucci, Rosana, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, Instituto de Salud Carlos III, Toscano-Guerra, Emily, Martínez-Gallo, Mónica, Arrese-Muñoz, Iria, Gine, Anna, Diaz, Noelia, Gabriel-Medina, Pablo, Riveiro-Barciela, Mar, Labrador-Horrillo, Moisés, Martínez-Valle, Fernando, Sánchez Montalvá, Adrián, Hernández-González, Manuel, Pujol Borrell, Ricardo, Rodríguez-Frías, Francisco, Ferrer, Roser, Thomson, Timothy M., and Paciucci, Rosana
- Abstract
Background SARS-CoV-2 infection portends a broad range of outcomes, from a majority of asymptomatic cases to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty, and co-morbidities such as obesity, diabetes, and cardiovascular disease. A precise knowledge of the molecular and biological mechanisms that may explain the association of severe disease with male sex is still lacking. Here, we analyzed the relationship of serum testosterone levels and the immune cell skewing with disease severity in male COVID-19 patients. Methods Biochemical and hematological parameters of admission samples in 497 hospitalized male and female COVID-19 patients, analyzed for associations with outcome and sex. Longitudinal (in-hospital course) analyses of a subcohort of 114 male patients were analyzed for associations with outcome. Longitudinal analyses of immune populations by flow cytometry in 24 male patients were studied for associations with outcome. Results We have found quantitative differences in biochemical predictors of disease outcome in male vs. female patients. Longitudinal analyses in a subcohort of male COVID-19 patients identified serum testosterone trajectories as the strongest predictor of survival (AUC of ROC = 92.8%, p < 0.0001) in these patients among all biochemical parameters studied, including single-point admission serum testosterone values. In lethal cases, longitudinal determinations of serum luteinizing hormone (LH) and androstenedione levels did not follow physiological feedback patterns. Failure to reinstate physiological testosterone levels was associated with evidence of impaired T helper differentiation and augmented circulating classical monocytes. Conclusions Recovery or failure to reinstate testosterone levels is strongly associated with survival or death, respectively, from COVID-19 in male patients. Our data suggest an early inhibition of the central LH-androgen biosynthesis axis in a majority of patients, followed
- Published
- 2022
3. Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients
- Author
-
Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, Instituto de Salud Carlos III, Toscano-Guerra, Emily [0000-0003-2718-1684], Martínez-Gallo, Mónica [0000-0002-7340-2161], Gabriel-Medina, Pablo [0000-0003-3079-6364], Riveiro-Barciela, Mar [0000-0001-9309-2052], Martínez-Valle, Fernando [0000-0003-2673-2034], Hernández-González, Manuel [0000-0002-6932-5853], Rodríguez-Frías, Francisco [0000-0002-9128-7013], Pujol Borrell, Ricardo [0000-0001-7833-675X], Ferrer, Roser [0000-0002-8925-3172], Thomson, Timothy M. [0000-0002-4670-9440], Paciucci, Rosana [0000-0002-1087-6378], Toscano-Guerra, Emily, Martínez-Gallo, Mónica, Arrese-Muñoz, Iria, Gine, Anna, Diaz, Noelia, Gabriel-Medina, Pablo, Riveiro-Barciela, Mar, Labrador-Horrillo, Moisés, Martínez-Valle, Fernando, Hernández-González, Manuel, Rodríguez-Frías, Francisco, Pujol Borrell, Ricardo, Ferrer, Roser, Thomson, Timothy M., Paciucci, Rosana, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, Instituto de Salud Carlos III, Toscano-Guerra, Emily [0000-0003-2718-1684], Martínez-Gallo, Mónica [0000-0002-7340-2161], Gabriel-Medina, Pablo [0000-0003-3079-6364], Riveiro-Barciela, Mar [0000-0001-9309-2052], Martínez-Valle, Fernando [0000-0003-2673-2034], Hernández-González, Manuel [0000-0002-6932-5853], Rodríguez-Frías, Francisco [0000-0002-9128-7013], Pujol Borrell, Ricardo [0000-0001-7833-675X], Ferrer, Roser [0000-0002-8925-3172], Thomson, Timothy M. [0000-0002-4670-9440], Paciucci, Rosana [0000-0002-1087-6378], Toscano-Guerra, Emily, Martínez-Gallo, Mónica, Arrese-Muñoz, Iria, Gine, Anna, Diaz, Noelia, Gabriel-Medina, Pablo, Riveiro-Barciela, Mar, Labrador-Horrillo, Moisés, Martínez-Valle, Fernando, Hernández-González, Manuel, Rodríguez-Frías, Francisco, Pujol Borrell, Ricardo, Ferrer, Roser, Thomson, Timothy M., and Paciucci, Rosana
- Abstract
Infection with SARS-CoV-2 portends a broad range of outcomes, from a majority of asymptomatic cases or mild clinical courses to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty and co-morbidities such as obesity, diabetes or cardiovascular disease. A precise knowledge is still lacking of the molecular and biological mechanisms that may explain the association of severe disease with male sex. Here, we show that testosterone trajectories are highly accurate individual predictors (AUC of ROC = 0.928, p < 0.0001) of survival in male COVID-19 patients. Longitudinal determinations of blood levels of luteinizing hormone (LH) and androstenedione suggest an early modest inhibition of the central LH-androgen biosynthesis axis in a majority of patients, followed by either full recovery in survivors or a peripheral failure in lethal cases. Moreover, failure to reinstate physiological testosterone levels was associated with evidence of impaired T helper differentiation and decrease of non-classical monocytes. The strong association of recovery or failure to reinstate testosterone levels with survival or death from COVID-19 in male patients is suggestive of a significant role of testosterone status in the immune responses to COVID-19.
- Published
- 2021
4. The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes
- Author
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European Research Council, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Generalitat Valenciana, Novais Bastos, Helder, Osório, Nuno S., Gagneux, Sebastien, Comas, Iñaki, Saraiva, Margarida, European Research Council, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Generalitat Valenciana, Novais Bastos, Helder, Osório, Nuno S., Gagneux, Sebastien, Comas, Iñaki, and Saraiva, Margarida
- Abstract
The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.
- Published
- 2018
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