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Fan Chang,1 Xiao Wang,1 Xiangning Huang,1 Xin Liu,1 Lijun Huang2 1Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 2West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Lijun Huang, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 18, Section 3, Renmin South Road, Wuhou District, Chengdu, Sichuan, People’s Republic of China, Email huanglijun93@163.comPurpose: To analyze the distribution of bacteria and their drug resistance changes in Intensive Care Units (ICUs) across Southwest China from 2018 to 2022 and establish the antibiogram in this region to provide a basis for early empirical antimicrobial use.Methods: Non-repetitive pathogens isolated from 109 member units with qualified data were obtained from the Antimicrobial Resistance Surveillance System in Sichuan Province, southwest China. The results obtained were interpreted with reference to CLSI M100-31th, and analyzed with WHONET 5.6 software.Results: A total of 46,728 clinical isolates in ICUs were collected from 2018 to 2022, of which gram-negative organisms accounted for 76.1%, and gram-positive were 23.9%. The top 5 were Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, respectively. From 2018 to 2022, the resistance rates of Klebsiella pneumoniae to imipenem and meropenem changed from 14.5% and 17.8% to 14.0% and 14.4%, showing a steady downward trend. Escherichia coli was always highly sensitive to carbapenems, with a total resistance rate of 3.8%. Among non-fermented gram-negative bacteria, the resistance rates of Pseudomonas aeruginosa to imipenem and meropenem decreased significantly, changed from 25.3% and 22.9% in 2018 t

Jin Li,1 Yajun Li,2 Ruolan Zeng,2 Jingguan Lin,1 Meizuo Zhong,3 Xianling Liu,4 Yizi He,2 Junqiao He,2 Zhou Ouyang,2 Lijun Huang,2 Ling Xiao,5 Hui Zhou2 1Department of Comprehensive Chemotherapy/Daytime Chemotherapy, Hunan Cancer Hospital, Changsha, Hunan, People’s Republic of China; 2Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, People’s Republic of China; 3Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 4Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 5Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Hui ZhouDepartment of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, People’s Republic of ChinaTel +86 731 89762281Email zhouhui9403@126.comPurpose: This retrospective study compared effectiveness between ≤ 4 cycles and ≥ 5 cycles of L-asparaginase/pegaspargase-based chemoradiation in newly diagnosed low-risk extranodal natural killer/T-cell lymphoma (ENKTL), nasal type classified according to the Prognostic Index of Natural Killer (PINK) lymphoma model.Patients and Methods: Patients were categorized into ≤ 4-cycle (2– 4 chemotherapy cycles, n = 166) and ≥ 5-cycle groups (5– 6 cycles, n = 86). Propensity score matching analysis was used to reduce potential confounding bias between the two groups. Treatment responses, adverse events, and survival outcomes between the two groups were analyzed.Results: No matter before or after matching (65 in the ≤ 4-cycle group, 65 in the ≥ 5-cycle group), response rates and survival outcomes were similar between the ≤ 4-cycle and ≥ 5-cycle groups. Incidences of grade 1– 2 anemia and transaminase e

Lijun Huang,1 Qiusheng Ren,1 Shenghui Yu,1 Ya Shao,1 Yijun Chen,2 Xin Huang1 1Department of Anesthesiology, Ningbo Yinzhou People’s Hospital, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, People’s Republic of China; 2Department of Anesthesiology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang, People’s Republic of ChinaCorrespondence: Lijun HuangDepartment of Anesthesiology, Ningbo Yinzhou People’s Hospital, The Affiliated People’s Hospital of Ningbo University, No. 251, East Baizhang Road, Ningbo, Zhejiang Province 315040, People’s Republic of ChinaEmail huanglijunyz@163.comObjective: The goal of the study was to investigate the efficacy of lipid supplement to epinephrine-based therapy in resuscitation of asphyxia-induced cardiac arrest in aged rats.Methods: The study included two parts: in experiment A, rats underwent asphyxial cardiac arrest and cardiopulmonary resuscitation, randomized to receive epinephrine and normal saline (control group, n=22), epinephrine and intralipid 20% (long-chain triglycerides (LCT) group, n=22) or epinephrine and lipovenoes 20% (LCT/medium-chain triglcerides (MCT) group, n=22). Return of spontaneous circulation, recurrence of asystole after resuscitation, hemodynamic metrics, arterial blood gas values, neurological assessment score and indexes of pulmonary transudation were recorded. In experiment B, rats using the same model and resuscitation protocol were randomly divided into 21 groups: Control 0, Control 20, Control 40, Control 60, Control 80, Control 100, Control 120, LCT 0, LCT 20, LCT 40, LCT 60, LCT 80, LCT 100, LCT 120, LCT/MCT 0, LCT/MCT 20, LCT/MCT 40, LCT/MCT 60, LCT/MCT 80, LCT/MCT 100 and LCT 120 (n=10, the subscripts represent respective endpoint of observation in minutes). Myocardial bioenergetics were determined.Results: In experiment A, the LCT and LCT/MCT groups had a shorter time to ret

Weiran Liu,1,* Shumin Xie,2,* Lin Yue,3,* Jiahao Liu,2 Stephanie Mu-Lian Woo,4 Weilin Liu,2 Adam R Miller,5 Jing Zhang,6 Lijun Huang,7 Lei Zhang8,*1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesia, Tianjin, People's Republic of China; 2The Xiangya Medical School of Central-South University, Changsha, People's Republic of China; 3Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Outpatient Service, Tianjin, People's Republic of China; 4Harvard University, Cambridge, MA, USA; 5Indiana University School of Medicine, Indianapolis, IN, USA; 6Tianjin Medical University, Tianjin, People's Republic of China; 7Hunan Provincial Tumor Hospital, Department of Lymphoma and Hematology, Changsha, People's Republic of China; 8Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Department of Thoracic Surgery, Tianjin, People's Republic of China *These authors contributed equally to this paperPurpose: To examine oncologists' knowledge of cancer pain and morphine's clinical application in the People's Republic of China. In addition, this study analyzes and discusses the negative factors that currently affect the clinical application of morphine.Patients and methods: A questionnaire survey was given to a random sample of 150 oncologists from Tianjin Medical University Cancer Institute and Hospital. The statistical results were analyzed and processed using SPSS version 21.0 and Matlab version 2012a statistical software. Single-factor analysis of variance, Kruskal–Wallis nonparametric test, and independent samples t-test were adopted to analyze the diff

A model of the regional and local geological setting, geophysical properties and prospecting criteria was derived from extensive studies at Gacun, the largest Au-bearing and Ag-rich polymetallic deposit in the SW Three Rivers area. The deposit, controlled by a local fault basin, was generated in a back-arc rift setting by predominantly acid magmas which evolved over a long period to basic. Prospecting criteria include the presence of Cu or vein-type Pb-Zn in cracks, oxidised sulphide minerals such as malachite and azurite, the existence of an intrusion centre, hydrothermal breccias, barite and dolomite rocks, and hydrothermal alteration such as chloritisation, sericitisation and silication. There are local positive magnetic and gravity anomalies and a regional intersection between remotely sensed circular and linear structures, as well as regional Pb, Zn, Cu, Ba and As anomalies. The massive orebodies have high density, low or negative magnetic susceptibility, high polarisation and low resistivity while the vein-stockwork orebodies display moderate density, low magnetic susceptibility and high polarisation., A model of the regional and local geological setting, geophysical properties and prospecting criteria was derived from extensive studies at Gacun, the largest Au-bearing and Ag-rich polymetallic deposit in the SW Three Rivers area. The deposit, controlled by a local fault basin, was generated in a back-arc rift setting by predominantly acid magmas which evolved over a long period to basic. Prospecting criteria include the presence of Cu or vein-type Pb-Zn in cracks, oxidised sulphide minerals such as malachite and azurite, the existence of an intrusion centre, hydrothermal breccias, barite and dolomite rocks, and hydrothermal alteration such as chloritisation, sericitisation and silication. There are local positive magnetic and gravity anomalies and a regional intersection between remotely sensed circular and linear structures, as well as regional Pb, Zn, Cu, Ba and As anomalies. The massive orebodies have high density, low or negative magnetic susceptibility, high polarisation and low resistivity while the vein-stockwork orebodies display moderate density, low magnetic susceptibility and high polarisation.