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3 results on '"Hristova, Rositsa"'

1. RENEB accident simulation exercise

Author

Brzozowska, Beata, Ainsbury, Elizabeth, Baert, Annelot, Beaton-Green, Lindsay, Barrios, Leonardo, Francesc Barquinero, Joan, Bassinet, Celine, Beinke, Christina, Benedek, Anett, Beukes, Philip, Bortolin, Emanuela, Buraczewska, Iwona, Burbidge, Christopher, De Amicis, Andrea, De Angelis, Cinzia, Della Monaca, Sara, Depuydt, Julie, De Sanctis, Stefania, Dobos, Katalin, Domene, Mercedes Moreno, Dominguez, Inmaculada, Facco, Eva, Fattibene, Paola, Frenzel, Monika, Gil, Octavia Monteiro, Gonon, Geraldine, Gregoire, Eric, Gruel, Gaetan, Hadjidekova, Valeria, Hatzi, Vasiliki I., Hristova, Rositsa, Jaworska, Alicja, Kis, Eniko, Kowalska, Maria, Kulka, Ulrike, Lista, Florigio, Lumniczky, Katalin, Martinez-Lopez, Wilner, Meschini, Roberta, Moertl, Simone, Moquet, Jayne, Noditi, Mihaela, Oestreicher, Ursula, Orta Vazquez, Manuel Luis, Palma, Valentina, Pantelias, Gabriel, Montoro Pastor, Alegria, Patrono, Clarice, Piqueret-Stephan, Laure, Quattrini, Maria Cristina, Regalbuto, Elisa, Ricoul, Michelle, Roch-Lefevre, Sandrine, Roy, Laurence, Sabatier, Laure, Sarchiapone, Lucia, Sebastia, Natividad, Sommer, Sylwester, Sun, Mingzhu, Suto, Yumiko, Terzoudi, Georgia, Trompier, Francois, Vral, Anne, Wilkins, Ruth, Zafiropoulos, Demetre, Wieser, Albrecht, Woda, Clemens, Wojcik, Andrzej, Brzozowska, Beata, Ainsbury, Elizabeth, Baert, Annelot, Beaton-Green, Lindsay, Barrios, Leonardo, Francesc Barquinero, Joan, Bassinet, Celine, Beinke, Christina, Benedek, Anett, Beukes, Philip, Bortolin, Emanuela, Buraczewska, Iwona, Burbidge, Christopher, De Amicis, Andrea, De Angelis, Cinzia, Della Monaca, Sara, Depuydt, Julie, De Sanctis, Stefania, Dobos, Katalin, Domene, Mercedes Moreno, Dominguez, Inmaculada, Facco, Eva, Fattibene, Paola, Frenzel, Monika, Gil, Octavia Monteiro, Gonon, Geraldine, Gregoire, Eric, Gruel, Gaetan, Hadjidekova, Valeria, Hatzi, Vasiliki I., Hristova, Rositsa, Jaworska, Alicja, Kis, Eniko, Kowalska, Maria, Kulka, Ulrike, Lista, Florigio, Lumniczky, Katalin, Martinez-Lopez, Wilner, Meschini, Roberta, Moertl, Simone, Moquet, Jayne, Noditi, Mihaela, Oestreicher, Ursula, Orta Vazquez, Manuel Luis, Palma, Valentina, Pantelias, Gabriel, Montoro Pastor, Alegria, Patrono, Clarice, Piqueret-Stephan, Laure, Quattrini, Maria Cristina, Regalbuto, Elisa, Ricoul, Michelle, Roch-Lefevre, Sandrine, Roy, Laurence, Sabatier, Laure, Sarchiapone, Lucia, Sebastia, Natividad, Sommer, Sylwester, Sun, Mingzhu, Suto, Yumiko, Terzoudi, Georgia, Trompier, Francois, Vral, Anne, Wilkins, Ruth, Zafiropoulos, Demetre, Wieser, Albrecht, Woda, Clemens, and Wojcik, Andrzej

Abstract

Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing potentially large data sets that would be generated in case of a major radiological event. Materials and methods: Each participant was offered the possibility to activate the network by sending an alerting email about a simulated radiation emergency. The same participant had to collect, compile and report capacity, triage categorization and exposure scenario results obtained from all other participants. The exercise was performed over 27 weeks and involved the network consisting of 28 institutes: 21 RENEB members, four candidates and three non-RENEB partners. Results: The duration of a single exercise never exceeded 10 days, while the response from the assisting laboratories never came later than within half a day. During each week of the exercise, around 4500 samples were reported by all service laboratories (SL) to be examined and 54 scenarios were coherently estimated by all laboratories (the standard deviation from the mean of all SL answers for a given scenario category and a set of data was not larger than 3 patient codes). Conclusions: Each participant received training in both the role of a reference laboratory (activating the network) and of a service laboratory (responding to an activation request). The procedures in the case of radiological event were successfully established and tested.

Published
2017
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2. Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons

Author

Ainsbury, Elizabeth, Badie, Christophe, Barnard, Stephen, Manning, Grainne, Moquet, Jayne, Abend, Michael, Antunes, Ana Catarina, Barrios, Lleonard, Bassinet, Celine, Beinke, Christina, Bortolin, Emanuela, Bossin, Lily, Bricknell, Clare, Brzoska, Kamil, Buraczewska, Iwona, Huertas Castano, Carlos, Cemusova, Zina, Christiansson, Maria, Mateos Cordero, Santiago, Coster, Guillaume, Della Monac, Sara, Desangles, Francois, Discher, Michael, Dominguez, Inmaculada, Doucha-Senf, Sven, Eakins, Jon, Fattibene, Paola, Filippi, Silvia, Frenzel, Monika, Georgieva, Dimka, Gregoire, Eric, Guogyte, Kamile, Hadjidekova, Valeria, Hadjiiska, Ljubomira, Hristova, Rositsa, Karakosta, Maria, Kis, Eniko, Kriehuber, Ralf, Lee, Jungil, Lloyd, David, Lumniczky, Katalin, Lyng, Fiona, Macaeva, Ellina, Majewski, Matthaeus, Vanda Martins, S., McKeever, Stephen W. S., Meade, Aidan, Medipally, Dinesh, Meschini, Roberta, M'kacher, Radhia, Gil, Octavia Monteiro, Montero, Alegria, Moreno, Mercedes, Noditi, Mihaela, Oestreicher, Ursula, Oskamp, Dominik, Palitti, Fabrizio, Palma, Valentina, Pantelias, Gabriel, Pateux, Jerome, Patrono, Clarice, Pepe, Gaetano, Port, Matthias, Jesus Prieto, Maria, Quattrini, Maria Cristina, Quintens, Roel, Ricoul, Michelle, Roy, Laurence, Sabatier, Laure, Sebastia, Natividad, Sholom, Sergey, Sommer, Sylwester, Staynova, Albena, Strunz, Sonja, Terzoudi, Georgia, Testa, Antonella, Trompier, Francois, Valente, Marco, Van Hoey, Olivier, Veronese, Ivan, Wojcik, Andrzej, Woda, Clemens, Ainsbury, Elizabeth, Badie, Christophe, Barnard, Stephen, Manning, Grainne, Moquet, Jayne, Abend, Michael, Antunes, Ana Catarina, Barrios, Lleonard, Bassinet, Celine, Beinke, Christina, Bortolin, Emanuela, Bossin, Lily, Bricknell, Clare, Brzoska, Kamil, Buraczewska, Iwona, Huertas Castano, Carlos, Cemusova, Zina, Christiansson, Maria, Mateos Cordero, Santiago, Coster, Guillaume, Della Monac, Sara, Desangles, Francois, Discher, Michael, Dominguez, Inmaculada, Doucha-Senf, Sven, Eakins, Jon, Fattibene, Paola, Filippi, Silvia, Frenzel, Monika, Georgieva, Dimka, Gregoire, Eric, Guogyte, Kamile, Hadjidekova, Valeria, Hadjiiska, Ljubomira, Hristova, Rositsa, Karakosta, Maria, Kis, Eniko, Kriehuber, Ralf, Lee, Jungil, Lloyd, David, Lumniczky, Katalin, Lyng, Fiona, Macaeva, Ellina, Majewski, Matthaeus, Vanda Martins, S., McKeever, Stephen W. S., Meade, Aidan, Medipally, Dinesh, Meschini, Roberta, M'kacher, Radhia, Gil, Octavia Monteiro, Montero, Alegria, Moreno, Mercedes, Noditi, Mihaela, Oestreicher, Ursula, Oskamp, Dominik, Palitti, Fabrizio, Palma, Valentina, Pantelias, Gabriel, Pateux, Jerome, Patrono, Clarice, Pepe, Gaetano, Port, Matthias, Jesus Prieto, Maria, Quattrini, Maria Cristina, Quintens, Roel, Ricoul, Michelle, Roy, Laurence, Sabatier, Laure, Sebastia, Natividad, Sholom, Sergey, Sommer, Sylwester, Staynova, Albena, Strunz, Sonja, Terzoudi, Georgia, Testa, Antonella, Trompier, Francois, Valente, Marco, Van Hoey, Olivier, Veronese, Ivan, Wojcik, Andrzej, and Woda, Clemens

Abstract

Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.

Published
2017
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3. RENEB biodosimetry intercomparison analyzing translocations by FISH

Author

Francesc Barquinero, Joan, Beinke, Christina, Borras, Mireia, Buraczewska, Iwona, Darroudi, Firouz, Gregoire, Eric, Hristova, Rositsa, Kulka, Ulrike, Lindholm, Carita, Moreno, Mercedes, Moquet, Jayne, Oestreicher, Ursula, Jesus Prieto, M., Pujol, Monica, Ricoul, Michelle, Sabatier, Laure, Sommer, Sylwester, Sun, Mingzhu, Wojcik, Andrzej, Barrios, Leonardo, Francesc Barquinero, Joan, Beinke, Christina, Borras, Mireia, Buraczewska, Iwona, Darroudi, Firouz, Gregoire, Eric, Hristova, Rositsa, Kulka, Ulrike, Lindholm, Carita, Moreno, Mercedes, Moquet, Jayne, Oestreicher, Ursula, Jesus Prieto, M., Pujol, Monica, Ricoul, Michelle, Sabatier, Laure, Sommer, Sylwester, Sun, Mingzhu, Wojcik, Andrzej, and Barrios, Leonardo

Abstract

Purpose: In the framework of RENEB, several biodosimetry exercises were conducted analyzing different endpoints. Among them, the analysis of translocations is considered the most useful method for retrospective biodosimetry due to the relative stability of their frequency with post irradiation time. The aim of this study was to harmonize the accuracy of translocation-based biodosimetry within the RENEB consortium. Materials and methods: An initial telescoring exercise analyzing FISH metaphase images was done to harmonize chromosome aberration descriptions. Then two blind intercomparison exercises (IE) were performed, by sending irradiated blood samples to each partner. Samples were cultured and stained by each partner using their standard protocol and translocation frequency was used to produce dose estimates. Results: The coefficient of variation in the 1st IE (CV = 0.34) was higher than in the 2nd IE (CV = 0.16 and 0.23 in the two samples analyzed), for the genomic frequency of total translocations. Z-score analysis revealed that eight out of 10 and 17 out of 20 dose estimates were satisfactory in the 1st and 2nd IE, respectively. Conclusions: The results obtained indicate that, despite the problems identified in few partners, which can be corrected, the RENEB consortium is able to carry out retrospective biodosimetry analyzing the frequency of translocations by FISH.

Published
2017
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