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Benchmarking is the de-facto standard for evaluating LLMs, due to its speed, replicability and low cost. However, recent work has pointed out that the majority of the open source benchmarks available today have been contaminated or leaked into LLMs, meaning that LLMs have access to test data during pretraining and/or fine-tuning. This raises serious concerns about the validity of benchmarking studies conducted so far and the future of evaluation using benchmarks. To solve this problem, we propose Private Benchmarking, a solution where test datasets are kept private and models are evaluated without revealing the test data to the model. We describe various scenarios (depending on the trust placed on model owners or dataset owners), and present solutions to avoid data contamination using private benchmarking. For scenarios where the model weights need to be kept private, we describe solutions from confidential computing and cryptography that can aid in private benchmarking. Finally, we present solutions the problem of benchmark dataset auditing, to ensure that private benchmarks are of sufficiently high quality.

Reviews and ratings by users form a central component in several widely used products today (e.g., product reviews, ratings of online content, etc.), but today's platforms for managing such reviews are ad-hoc and vulnerable to various forms of tampering and hijack by fake reviews either by bots or motivated paid workers. We define a new metric called 'hijack-resistance' for such review platforms, and then present TrustRate, an end-to-end decentralized, hijack-resistant platform for authentic, anonymous, tamper-proof reviews. With a prototype implementation and evaluation at the scale of thousands of nodes, we demonstrate the efficacy and performance of our platform, towards a new paradigm for building products based on trusted reviews by end users without having to trust a single organization that manages the reviews., Comment: 23 pages

IntroductionWe evaluated real-world outcomes in patients with advanced ovarian cancer (AOC) based on their cumulative risk profile and maintenance therapy (MT) status following first-line (1L) treatment.MethodsThis retrospective observational study of a nationwide electronic health record-derived de-identified database included adult patients diagnosed with stage III/IV OC from January 1, 2011 to February 28, 2021, who received 1L therapy and had ≥ 12 weeks of follow-up after the index date (end of 1L therapy). Patients were grouped according to whether they received MT or active surveillance (AS) following 1L treatment and by the cumulative number of risk factors (RF) present (stage IV disease; no surgery/treated with neoadjuvant therapy and interval debulking surgery; had postoperative visible residual disease; and had BRCA wild-type disease/unknown BRCA status). Time to next treatment (TTNT) and overall survival (OS) were assessed with a cloning and inverse probability of censoring (IPC)-weighted Kaplan-Meier method.ResultsAmong 1920 patients, 22.2% received MT and 77.8% received AS. Median IPC-weighted TTNT and OS were 13.3 months (95% CI 11.7-15.8) and 39.1 months (95% CI 32.5-48.6) in the MT cohort, respectively, and 8.6 months (95% CI 8.0-9.5) and 38.4 months (95% CI 36.4-41.0) in the AS cohort, respectively. Almost all patients had ≥ 1 RF (MT 95.3%; AS 96.7%). Median IPC-weighted TTNT was shorter among patients with more RF in both cohorts (MT: 1 RF, 19.3 months, 95% CI 13.5-37.8; 2 RF, 17.2 months, 95% CI 12.8-20.2; 3 RF, 11.0 months, 95% CI 8.2-13.8; 4 RF, 7.0 months, 95% CI 6.2-8.8; AS: 1 RF, 17.7 months, 95% CI 13.5-22.3; 2 RF, 10.2 months, 95% CI 9.1-11.5; 3 RF, 6.5 months, 95% CI 5.8-7.4; 4 RF, 4.1 months, 95% CI 3.5-4.5).ConclusionRegardless of RF number, MT was associa

This paper addresses privacy concerns in multi-agent reinforcement learning (MARL), specifically within the context of supply chains where individual strategic data must remain confidential. Organizations within the supply chain are modeled as agents, each seeking to optimize their own objectives while interacting with others. As each organization's strategy is contingent on neighboring strategies, maintaining privacy of state and action-related information is crucial. To tackle this challenge, we propose a game-theoretic, privacy-preserving mechanism, utilizing a secure multi-party computation (MPC) framework in MARL settings. Our major contribution is the successful implementation of a secure MPC framework, SecFloat on EzPC, to solve this problem. However, simply implementing policy gradient methods such as MADDPG operations using SecFloat, while conceptually feasible, would be programmatically intractable. To overcome this hurdle, we devise a novel approach that breaks down the forward and backward pass of the neural network into elementary operations compatible with SecFloat , creating efficient and secure versions of the MADDPG algorithm. Furthermore, we present a learning mechanism that carries out floating point operations in a privacy-preserving manner, an important feature for successful learning in MARL framework. Experiments reveal that there is on average 68.19% less supply chain wastage in 2 PC compared to no data share, while also giving on average 42.27% better average cumulative revenue for each player. This work paves the way for practical, privacy-preserving MARL, promising significant improvements in secure computation within supply chain contexts and broadly.

In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline BRCA-mutated (non-gBRCAm) cohort of the ENGOT-OV16/NOVA trial (NCT01847274), which evaluated niraparib maintenance therapy for patients with recurrent ovarian cancer. This post hoc exploratory biomarker analysis was performed using tumor samples collected from 331 patients enrolled in the phase III ENGOT-OV16/NOVA trial's non-gBRCAm cohort. Niraparib demonstrated PFS benefit in patients with either somatic BRCA-mutated (sBRCAm; HR, 0.27; 95% confidence interval, CI, 0.08–0.88) or BRCA wild-type (BRCAwt; HR, 0.47; 95% CI, 0.34–0.64) tumors. Patients with BRCAwt tumors with other non-BRCA HRR mutations also derived benefit from niraparib (HR, 0.31; 95% CI, 0.13–0.77), as did patients with BRCAwt/HRRwt (HRR wild-type) tumors (HR, 0.49; 95% CI, 0.35–0.70). When patients with BRCAwt/HRRwt tumors were further categorized by genomic instability score (GIS), clinical benefit was observed in patients with homologous recombination–deficient (GIS ≥ 42; HR, 0.33; 95% CI, 0.18–0.61) and in patients with homologous recombination–proficient (HRp; GIS < 42; HR, 0.60; 95% CI, 0.36–0.99) disease. Although patients with sBRCAm, other non-BRCA HRR mutations, or GIS ≥ 42 benefited the most from niraparib treatment, PFS benefit was also seen in HRp (GIS < 42) patients without HRR mutations. These results support the use of niraparib in patients with recurrent ovarian cancer regardless of BRCA/HRR mutation status or myChoice CDx GIS. Significance: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline BRCA-mutated cohort of the phase III NOVA trial of patients with platinum-sensitive high-grade serous ovarian cancer. Patients with non-BRCA HRR mutations generally benefited from second-line maintenance treatment with niraparib compa

In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline BRCA-mutated (non-gBRCAm) cohort of the ENGOT-OV16/NOVA trial (NCT01847274), which evaluated niraparib maintenance therapy for patients with recurrent ovarian cancer. This post hoc exploratory biomarker analysis was performed using tumor samples collected from 331 patients enrolled in the phase III ENGOT-OV16/NOVA trial's non-gBRCAm cohort. Niraparib demonstrated PFS benefit in patients with either somatic BRCA-mutated (sBRCAm; HR, 0.27; 95% confidence interval, CI, 0.08–0.88) or BRCA wild-type (BRCAwt; HR, 0.47; 95% CI, 0.34–0.64) tumors. Patients with BRCAwt tumors with other non-BRCA HRR mutations also derived benefit from niraparib (HR, 0.31; 95% CI, 0.13–0.77), as did patients with BRCAwt/HRRwt (HRR wild-type) tumors (HR, 0.49; 95% CI, 0.35–0.70). When patients with BRCAwt/HRRwt tumors were further categorized by genomic instability score (GIS), clinical benefit was observed in patients with homologous recombination–deficient (GIS ≥ 42; HR, 0.33; 95% CI, 0.18–0.61) and in patients with homologous recombination–proficient (HRp; GIS < 42; HR, 0.60; 95% CI, 0.36–0.99) disease. Although patients with sBRCAm, other non-BRCA HRR mutations, or GIS ≥ 42 benefited the most from niraparib treatment, PFS benefit was also seen in HRp (GIS < 42) patients without HRR mutations. These results support the use of niraparib in patients with recurrent ovarian cancer regardless of BRCA/HRR mutation status or myChoice CDx GIS. Significance: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline BRCA-mutated cohort of the phase III NOVA trial of patients with platinum-sensitive high-grade serous ovarian cancer. Patients with non-BRCA HRR mutations generally benefited from second-line maintenance treatment with ni, UNLABELLED: In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline BRCA-mutated (non-gBRCAm) cohort of the ENGOT-OV16/NOVA trial (NCT01847274), which evaluated niraparib maintenance therapy for patients with recurrent ovarian cancer. This post hoc exploratory biomarker analysis was performed using tumor samples collected from 331 patients enrolled in the phase III ENGOT-OV16/NOVA trial's non-gBRCAm cohort. Niraparib demonstrated PFS benefit in patients with either somatic BRCA-mutated (sBRCAm; HR, 0.27; 95% confidence interval, CI, 0.08-0.88) or BRCA wild-type (BRCAwt; HR, 0.47; 95% CI, 0.34-0.64) tumors. Patients with BRCAwt tumors with other non-BRCA HRR mutations also derived benefit from niraparib (HR, 0.31; 95% CI, 0.13-0.77), as did patients with BRCAwt/HRRwt (HRR wild-type) tumors (HR, 0.49; 95% CI, 0.35-0.70). When patients with BRCAwt/HRRwt tumors were further categorized by genomic instability score (GIS), clinical benefit was observed in patients with homologous recombination-deficient (GIS ≥ 42; HR, 0.33; 95% CI, 0.18-0.61) and in patients with homologous recombination-proficient (HRp; GIS < 42; HR, 0.60; 95% CI, 0.36-0.99) disease. Although patients with sBRCAm, other non-BRCA HRR mutations, or GIS ≥ 42 benefited the most from niraparib treatment, PFS benefit was also seen in HRp (GIS < 42) patients without HRR mutations. These results support the use of niraparib in patients with recurrent ovarian cancer regardless of BRCA/HRR mutation status or myChoice CDx GIS.SIGNIFICANCE: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline BRCA-mutated cohort of the phase III NOVA trial of patients with platinum-sensitive high-grade serous ovarian cancer. Patients with non-BRCA HRR mutations generally benefited from second-line maintenance treatment

ML-as-a-service continues to grow, and so does the need for very strong privacy guarantees. Secure inference has emerged as a potential solution, wherein cryptographic primitives allow inference without revealing users' inputs to a model provider or model's weights to a user. For instance, the model provider could be a diagnostics company that has trained a state-of-the-art DenseNet-121 model for interpreting a chest X-ray and the user could be a patient at a hospital. While secure inference is in principle feasible for this setting, there are no existing techniques that make it practical at scale. The CrypTFlow2 framework provides a potential solution with its ability to automatically and correctly translate clear-text inference to secure inference for arbitrary models. However, the resultant secure inference from CrypTFlow2 is impractically expensive: Almost 3TB of communication is required to interpret a single X-ray on DenseNet-121. In this paper, we address this outstanding challenge of inefficiency of secure inference with three contributions. First, we show that the primary bottlenecks in secure inference are large linear layers which can be optimized with the choice of network backbone and the use of operators developed for efficient clear-text inference. This finding and emphasis deviates from many recent works which focus on optimizing non-linear activation layers when performing secure inference of smaller networks. Second, based on analysis of a bottle-necked convolution layer, we design a X-operator which is a more efficient drop-in replacement. Third, we show that the fast Winograd convolution algorithm further improves efficiency of secure inference. In combination, these three optimizations prove to be highly effective for the problem of X-ray interpretation trained on the CheXpert dataset., Comment: 10 pages include references, 4 figures

In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline BRCA-mutated (non-gBRCAm) cohort of the ENGOT-OV16/NOVA trial (NCT01847274), which evaluated niraparib maintenance therapy for patients with recurrent ovarian cancer. This post hoc exploratory biomarker analysis was performed using tumor samples collected from 331 patients enrolled in the phase III ENGOT-OV16/NOVA trial's non-gBRCAm cohort. Niraparib demonstrated PFS benefit in patients with either somatic BRCA-mutated (sBRCAm; HR, 0.27; 95% confidence interval, CI, 0.08–0.88) or BRCA wild-type (BRCAwt; HR, 0.47; 95% CI, 0.34–0.64) tumors. Patients with BRCAwt tumors with other non-BRCA HRR mutations also derived benefit from niraparib (HR, 0.31; 95% CI, 0.13–0.77), as did patients with BRCAwt/HRRwt (HRR wild-type) tumors (HR, 0.49; 95% CI, 0.35–0.70). When patients with BRCAwt/HRRwt tumors were further categorized by genomic instability score (GIS), clinical benefit was observed in patients with homologous recombination–deficient (GIS ≥ 42; HR, 0.33; 95% CI, 0.18–0.61) and in patients with homologous recombination–proficient (HRp; GIS < 42; HR, 0.60; 95% CI, 0.36–0.99) disease. Although patients with sBRCAm, other non-BRCA HRR mutations, or GIS ≥ 42 benefited the most from niraparib treatment, PFS benefit was also seen in HRp (GIS < 42) patients without HRR mutations. These results support the use of niraparib in patients with recurrent ovarian cancer regardless of BRCA/HRR mutation status or myChoice CDx GIS. Significance: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline BRCA-mutated cohort of the phase III NOVA trial of patients with platinum-sensitive high-grade serous ovarian cancer. Patients with non-BRCA HRR mutations generally benefited from second-line maintenance treatment with niraparib compa

In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline BRCA-mutated (non-gBRCAm) cohort of the ENGOT-OV16/NOVA trial (NCT01847274), which evaluated niraparib maintenance therapy for patients with recurrent ovarian cancer. This post hoc exploratory biomarker analysis was performed using tumor samples collected from 331 patients enrolled in the phase III ENGOT-OV16/NOVA trial's non-gBRCAm cohort. Niraparib demonstrated PFS benefit in patients with either somatic BRCA-mutated (sBRCAm; HR, 0.27; 95% confidence interval, CI, 0.08–0.88) or BRCA wild-type (BRCAwt; HR, 0.47; 95% CI, 0.34–0.64) tumors. Patients with BRCAwt tumors with other non-BRCA HRR mutations also derived benefit from niraparib (HR, 0.31; 95% CI, 0.13–0.77), as did patients with BRCAwt/HRRwt (HRR wild-type) tumors (HR, 0.49; 95% CI, 0.35–0.70). When patients with BRCAwt/HRRwt tumors were further categorized by genomic instability score (GIS), clinical benefit was observed in patients with homologous recombination–deficient (GIS ≥ 42; HR, 0.33; 95% CI, 0.18–0.61) and in patients with homologous recombination–proficient (HRp; GIS < 42; HR, 0.60; 95% CI, 0.36–0.99) disease. Although patients with sBRCAm, other non-BRCA HRR mutations, or GIS ≥ 42 benefited the most from niraparib treatment, PFS benefit was also seen in HRp (GIS < 42) patients without HRR mutations. These results support the use of niraparib in patients with recurrent ovarian cancer regardless of BRCA/HRR mutation status or myChoice CDx GIS. Significance: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline BRCA-mutated cohort of the phase III NOVA trial of patients with platinum-sensitive high-grade serous ovarian cancer. Patients with non-BRCA HRR mutations generally benefited from second-line maintenance treatment with ni, UNLABELLED: In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline BRCA-mutated (non-gBRCAm) cohort of the ENGOT-OV16/NOVA trial (NCT01847274), which evaluated niraparib maintenance therapy for patients with recurrent ovarian cancer. This post hoc exploratory biomarker analysis was performed using tumor samples collected from 331 patients enrolled in the phase III ENGOT-OV16/NOVA trial's non-gBRCAm cohort. Niraparib demonstrated PFS benefit in patients with either somatic BRCA-mutated (sBRCAm; HR, 0.27; 95% confidence interval, CI, 0.08-0.88) or BRCA wild-type (BRCAwt; HR, 0.47; 95% CI, 0.34-0.64) tumors. Patients with BRCAwt tumors with other non-BRCA HRR mutations also derived benefit from niraparib (HR, 0.31; 95% CI, 0.13-0.77), as did patients with BRCAwt/HRRwt (HRR wild-type) tumors (HR, 0.49; 95% CI, 0.35-0.70). When patients with BRCAwt/HRRwt tumors were further categorized by genomic instability score (GIS), clinical benefit was observed in patients with homologous recombination-deficient (GIS ≥ 42; HR, 0.33; 95% CI, 0.18-0.61) and in patients with homologous recombination-proficient (HRp; GIS < 42; HR, 0.60; 95% CI, 0.36-0.99) disease. Although patients with sBRCAm, other non-BRCA HRR mutations, or GIS ≥ 42 benefited the most from niraparib treatment, PFS benefit was also seen in HRp (GIS < 42) patients without HRR mutations. These results support the use of niraparib in patients with recurrent ovarian cancer regardless of BRCA/HRR mutation status or myChoice CDx GIS.SIGNIFICANCE: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline BRCA-mutated cohort of the phase III NOVA trial of patients with platinum-sensitive high-grade serous ovarian cancer. Patients with non-BRCA HRR mutations generally benefited from second-line maintenance treatment

Background: Migraine is a common episodic neurological disorder with complex pathophysiology that manifests as recurrent attacks of typically throbbing and unilateral, often severe headache with associated features such as nausea, phonophobia, and photophobia. It has been found that neck pain has a significant link with migraine headaches. It is necessary to provide an adjunctive treatment to help reduce the occurrence and adverse effects of migraine headaches. This study aims to establish the effect of neck muscles activation on migraine headaches in students. Aim: To determine the immediate effect of deep neck muscles activation on migraine headaches in students. Methods: A total 35 subjects between 18–25 years diagnosed with migraine were selected for study. Subjects received exercises for deep neck muscle activation. Each session was conducted for 30 minutes duration, 4 days per week for 3 weeks. Outcome measure used was Migraine Disability Index scale (MIDAS). Statiscal Analysis: Statistical analysis was done using unpaired t test. Results: The results of the study demonstrate that there was a significant effect of the deep neck muscles activation on MIDAS scores (p = 0.0031), frequency of headaches (p = 0.0138) and intensity of pain experienced during migraine headaches (p<0.0001) during the pre and post intervention assessment. Conclusion: Activation of deep neck muscles effectively reduced the disability caused by migraine, frequency of headaches and intensity of pain experienced during migraine headaches in students.

Background: Migraine is a common episodic neurological disorder with complex pathophysiology that manifests as recurrent attacks of typically throbbing and unilateral, often severe headache with associated features such as nausea, phonophobia, and photophobia. It has been found that neck pain has a significant link with migraine headaches. It is necessary to provide an adjunctive treatment to help reduce the occurrence and adverse effects of migraine headaches. This study aims to establish the effect of neck muscles activation on migraine headaches in students. Aim: To determine the immediate effect of deep neck muscles activation on migraine headaches in students. Methods: A total 35 subjects between 18–25 years diagnosed with migraine were selected for study. Subjects received exercises for deep neck muscle activation. Each session was conducted for 30 minutes duration, 4 days per week for 3 weeks. Outcome measure used was Migraine Disability Index scale (MIDAS). Statiscal Analysis: Statistical analysis was done using unpaired t test. Results: The results of the study demonstrate that there was a significant effect of the deep neck muscles activation on MIDAS scores (p = 0.0031), frequency of headaches (p = 0.0138) and intensity of pain experienced during migraine headaches (p<0.0001) during the pre and post intervention assessment. Conclusion: Activation of deep neck muscles effectively reduced the disability caused by migraine, frequency of headaches and intensity of pain experienced during migraine headaches in students.

Adoption of artificial intelligence medical imaging applications is often impeded by barriers between healthcare systems and algorithm developers given that access to both private patient data and commercial model IP is important to perform pre-deployment evaluation. This work investigates a framework for secure, privacy-preserving and AI-enabled medical imaging inference using CrypTFlow2, a state-of-the-art end-to-end compiler allowing cryptographically secure 2-party Computation (2PC) protocols between the machine learning model vendor and target patient data owner. A common DenseNet-121 chest x-ray diagnosis model was evaluated on multi-institutional chest radiographic imaging datasets both with and without CrypTFlow2 on two test sets spanning seven sites across the US and India, and comprising 1,149 chest x-ray images. We measure comparative AUROC performance between secure and insecure inference in multiple pathology classification tasks, and explore model output distributional shifts and resource constraints introduced by secure model inference. Secure inference with CrypTFlow2 demonstrated no significant difference in AUROC for all diagnoses, and model outputs from secure and insecure inference methods were distributionally equivalent. The use of CrypTFlow2 may allow off-the-shelf secure 2PC between healthcare systems and AI model vendors for medical imaging, without changes in performance, and can facilitate scalable pre-deployment infrastructure for real-world secure model evaluation without exposure to patient data or model IP.

Complex machine learning (ML) inference algorithms like recurrent neural networks (RNNs) use standard functions from math libraries like exponentiation, sigmoid, tanh, and reciprocal of square root. Although prior work on secure 2-party inference provides specialized protocols for convolutional neural networks (CNNs), existing secure implementations of these math operators rely on generic 2-party computation (2PC) protocols that suffer from high communication. We provide new specialized 2PC protocols for math functions that crucially rely on lookup-tables and mixed-bitwidths to address this performance overhead; our protocols for math functions communicate up to 423x less data than prior work. Some of the mixed bitwidth operations used by our math implementations are (zero and signed) extensions, different forms of truncations, multiplication of operands of mixed-bitwidths, and digit decomposition (a generalization of bit decomposition to larger digits). For each of these primitive operations, we construct specialized 2PC protocols that are more communication efficient than generic 2PC, and can be of independent interest. Furthermore, our math implementations are numerically precise, which ensures that the secure implementations preserve model accuracy of cleartext. We build on top of our novel protocols to build SIRNN, a library for end-to-end secure 2-party DNN inference, that provides the first secure implementations of an RNN operating on time series sensor data, an RNN operating on speech data, and a state-of-the-art ML architecture that combines CNNs and RNNs for identifying all heads present in images. Our evaluation shows that SIRNN achieves up to three orders of magnitude of performance improvement when compared to inference of these models using an existing state-of-the-art 2PC framework., Comment: IEEE Security and Privacy 2021

This paper presents EinsteinPy (version 0.3), a community-developed Python package for gravitational and relativistic astrophysics. Python is a free, easy to use a high-level programming language which has seen a huge expansion in the number of its users and developers in recent years. Specifically, a lot of recent studies show that the use of Python in Astrophysics and general physics has increased exponentially. We aim to provide a very high level of abstraction, an easy to use interface and pleasing user experience. EinsteinPy is developed keeping in mind the state of a theoretical gravitational physicist with little or no background in computer programming and trying to work in the field of numerical relativity or trying to use simulations in their research. Currently, EinsteinPy supports simulation of time-like and null geodesics and calculates trajectories in different background geometries some of which are Schwarzschild, Kerr, and KerrNewmann along with coordinate inter-conversion pipeline. It has a partially developed pipeline for plotting and visualization with dependencies on libraries like Plotly, matplotlib, etc. One of the unique features of EinsteinPy is a sufficiently developed symbolic tensor manipulation utilities which are a great tool in itself for teaching yourself tensor algebra which for many beginner students can be overwhelmingly tricky. EinsteinPy also provides few utility functions for hypersurface embedding of Schwarzschild spacetime which further will be extended to model gravitational lensing simulation., Comment: We plan to submit it to A&A. 9 pages

This paper presents EinsteinPy (version 0.3), a community-developed Python package for gravitational and relativistic astrophysics. Python is a free, easy to use a high-level programming language which has seen a huge expansion in the number of its users and developers in recent years. Specifically, a lot of recent studies show that the use of Python in Astrophysics and general physics has increased exponentially. We aim to provide a very high level of abstraction, an easy to use interface and pleasing user experience. EinsteinPy is developed keeping in mind the state of a theoretical gravitational physicist with little or no background in computer programming and trying to work in the field of numerical relativity or trying to use simulations in their research. Currently, EinsteinPy supports simulation of time-like and null geodesics and calculates trajectories in different background geometries some of which are Schwarzschild, Kerr, and KerrNewmann along with coordinate inter-conversion pipeline. It has a partially developed pipeline for plotting and visualization with dependencies on libraries like Plotly, matplotlib, etc. One of the unique features of EinsteinPy is a sufficiently developed symbolic tensor manipulation utilities which are a great tool in itself for teaching yourself tensor algebra which for many beginner students can be overwhelmingly tricky. EinsteinPy also provides few utility functions for hypersurface embedding of Schwarzschild spacetime which further will be extended to model gravitational lensing simulation., Comment: We plan to submit it to A&A. 9 pages

We present CRYPTFLOW, a system that converts TensorFlow inference code into Secure Multi-party Computation (MPC) protocols at the push of a button. To do this, we build two components. Our first component is an end-to-end compiler from TensorFlow to a variety of MPC protocols. The second component is an improved semi-honest 3-party protocol that provides significant speedups for inference. We empirically demonstrate the power of our system by showing the secure inference of real-world neural networks such as DENSENET121 for detection of lung diseases from chest X-ray images and 3D-UNet for segmentation in radiotherapy planning using CT images. In particular, this paper provides the first evaluation of secure segmentation of 3D images, a task that requires much more powerful models than classification and is the largest secure inference task run till date., Comment: 6 pages. PPML NeurIPS 2020 Workshop, Vancouver, Canada. arXiv admin note: substantial text overlap with arXiv:1909.07814

We introduce Blockene, a blockchain that reduces resource usage at member nodes by orders of magnitude, requiring only a smartphone to participate in block validation and consensus. Despite being lightweight, Blockene provides a high throughput of transactions and scales to a large number of participants. Blockene consumes negligible battery and data in smartphones, enabling millions of users to participate in the blockchain without incentives, to secure transactions with their collective honesty. Blockene achieves these properties with a novel split-trust design based on delegating storage and gossip to untrusted nodes. We show, with a prototype implementation, that Blockene provides throughput of 1045 transactions/sec, and runs with very low resource usage on smartphones, pointing to a new paradigm for building secure, decentralized applications., Comment: A version of this paper (without the appendix) will appear in OSDI 2020

We present CrypTFlow2, a cryptographic framework for secure inference over realistic Deep Neural Networks (DNNs) using secure 2-party computation. CrypTFlow2 protocols are both correct -- i.e., their outputs are bitwise equivalent to the cleartext execution -- and efficient -- they outperform the state-of-the-art protocols in both latency and scale. At the core of CrypTFlow2, we have new 2PC protocols for secure comparison and division, designed carefully to balance round and communication complexity for secure inference tasks. Using CrypTFlow2, we present the first secure inference over ImageNet-scale DNNs like ResNet50 and DenseNet121. These DNNs are at least an order of magnitude larger than those considered in the prior work of 2-party DNN inference. Even on the benchmarks considered by prior work, CrypTFlow2 requires an order of magnitude less communication and 20x-30x less time than the state-of-the-art., Comment: To appear at ACM CCS 2020. Code available at: https://github.com/mpc-msri/EzPC

Due to modernization and increased stress in daily life, life style have been changed which  results into many endocrinal diseases, Hypothyroidism is one among them. Stress plays a major role in  hypothyroidism pathogenesis. In Samhitas there is no direct reference of hypothyroidism but due to increased  stress in our routine life it alters hypothalamus-pituitary-thyroid axis activity. In contemporary system of  medicine, the drug of choice for Hypothyroidism is levothyroxine. Side effects of these drugs are increased  hunger, muscle weakness, irregular periods, diarrhoea, excessive sweating, fever, hair loss, etc. In Ayurveda there  is not any direct reference of chikitsa of hypothyroidism but it can be managed by using stress relieving and kapha vatahar chikitsa like shirodhara, abhyanga, various medhya rasyana. Laughter therapy and yoga also plays  a major role in reducing stress. This study was carried out using through various ayurvedic classical text, pubmed,  google scholar as well as available modern literature, collected data and observation were presented in a scientific  manner. The review will be beneficial to understand the pathogenesis of hypothyroidism and modify the line of  treatment of disease.&nbsp

We present CrypTFlow, a first of its kind system that converts TensorFlow inference code into Secure Multi-party Computation (MPC) protocols at the push of a button. To do this, we build three components. Our first component, Athos, is an end-to-end compiler from TensorFlow to a variety of semi-honest MPC protocols. The second component, Porthos, is an improved semi-honest 3-party protocol that provides significant speedups for TensorFlow like applications. Finally, to provide malicious secure MPC protocols, our third component, Aramis, is a novel technique that uses hardware with integrity guarantees to convert any semi-honest MPC protocol into an MPC protocol that provides malicious security. The malicious security of the protocols output by Aramis relies on integrity of the hardware and semi-honest security of MPC. Moreover, our system matches the inference accuracy of plaintext TensorFlow. We experimentally demonstrate the power of our system by showing the secure inference of real-world neural networks such as ResNet50 and DenseNet121 over the ImageNet dataset with running times of about 30 seconds for semi-honest security and under two minutes for malicious security. Prior work in the area of secure inference has been limited to semi-honest security of small networks over tiny datasets such as MNIST or CIFAR. Even on MNIST/CIFAR, CrypTFlow outperforms prior work., Comment: To appear at 41st IEEE Symposium on Security and Privacy 2020. Code available at: https://github.com/mpc-msri/EzPC

Recently, candidate constructions were given for indistinguishability obfuscation by Garg, Gentry, Halevi, Raykova, Sahai, and Waters [FOCS'13]. The goal of general-purpose program obfuscation is to make an arbitrary computer program ``unintelligible'' while preserving its functionality. Since then, this new tool has been used to obtain many new applications. In this dissertation, we study the problem of protecting software against new and powerful adversary structures as well as optimize the efficiency of secure general-purpose obfuscation schemes.In the first part of this dissertation, we initiate the study of hosting services on an untrusted cloud. Specifically, we consider a scenario where a service provider has created a software service S and desires to outsource the execution of this service to an untrusted cloud. The software service contains secrets that the provider would like to keep hidden from the cloud. For example, the software might contain a secret database, and the service could allowusers to make queries to different slices of this database depending on the user's identity. Furthermore, we seek to protect knowledge of the software S to the maximum extent possible even if the cloud can collude with several corrupted users. We provide the first formalizations of security for this setting, and construction relying on indistinguishabilityobfuscation.The great interest in the utility of obfuscation leads to a natural and pressing goal: to improve the efficiency of general-purpose obfuscation. In the second part of this dissertation, we initiate the work to optimize the efficiency of secure general-purpose obfuscation schemes.We focus on the problem of optimizing the obfuscation of Boolean formulas and branchingprograms - this corresponds to optimizing the ``core obfuscator'' from the work of Garg \etal, and all subsequent works constructing general-purpose obfuscators. Our efficiency improvement is obtained by generalizing the class of branching progra

Recently, candidate constructions were given for indistinguishability obfuscation by Garg, Gentry, Halevi, Raykova, Sahai, and Waters [FOCS'13]. The goal of general-purpose program obfuscation is to make an arbitrary computer program ``unintelligible'' while preserving its functionality. Since then, this new tool has been used to obtain many new applications. In this dissertation, we study the problem of protecting software against new and powerful adversary structures as well as optimize the efficiency of secure general-purpose obfuscation schemes.In the first part of this dissertation, we initiate the study of hosting services on an untrusted cloud. Specifically, we consider a scenario where a service provider has created a software service S and desires to outsource the execution of this service to an untrusted cloud. The software service contains secrets that the provider would like to keep hidden from the cloud. For example, the software might contain a secret database, and the service could allowusers to make queries to different slices of this database depending on the user's identity. Furthermore, we seek to protect knowledge of the software S to the maximum extent possible even if the cloud can collude with several corrupted users. We provide the first formalizations of security for this setting, and construction relying on indistinguishabilityobfuscation.The great interest in the utility of obfuscation leads to a natural and pressing goal: to improve the efficiency of general-purpose obfuscation. In the second part of this dissertation, we initiate the work to optimize the efficiency of secure general-purpose obfuscation schemes.We focus on the problem of optimizing the obfuscation of Boolean formulas and branchingprograms - this corresponds to optimizing the ``core obfuscator'' from the work of Garg \etal, and all subsequent works constructing general-purpose obfuscators. Our efficiency improvement is obtained by generalizing the class of branching progra

We study the Unsplittable Flow Problem (UFP) and related variants, namely UFP with Bag Constraints and UFP with Rounds, on paths and trees. We provide improved constant factor approximation algorithms for all these problems under the no bottleneck assumption (NBA), which says that the maximum demand for any source-sink pair is at most the minimum capacity of any edge. We obtain these improved results by expressing a feasible solution to a natural LP relaxation of the UFP as a near-convex combination of feasible integral solutions.

We study the Unsplittable Flow Problem (UFP) and related variants, namely UFP with Bag Constraints and UFP with Rounds, on paths and trees. We provide improved constant factor approximation algorithms for all these problems under the no bottleneck assumption (NBA), which says that the maximum demand for any source-sink pair is at most the minimum capacity of any edge. We obtain these improved results by expressing a feasible solution to a natural LP relaxation of the UFP as a near-convex combination of feasible integral solutions.

In this work, we consider the long-standing open question of constructing constant-round concurrent zero-knowledge protocols in the plain model. Resolving this question is known to require non-black-box techniques. We consider non-black-box techniques for zero-knowledge based on knowledge assumptions, a line of thinking initiated by the work of Hada and Tanaka (CRYPTO 1998). Prior to our work, it was not known whether knowledge assumptions could be used for achieving security in the concurrent setting, due to a number of significant limitations that we discuss here. Nevertheless, we obtain the following results: 1. We obtain the first constant round concurrent zero-knowledge argument for \textbf{NP} in the plain model based on a new variant of knowledge of exponent assumption. Furthermore, our construction avoids the inefficiency inherent in previous non-black-box techniques such that those of Barak (FOCS 2001); we obtain our result through an efficient protocol compiler. 2. Unlike Hada and Tanaka, we do not require a knowledge assumption to argue the soundness of our protocol. Instead, we use a discrete log like assumption, which we call Diffie-Hellman Logarithm Assumption, to prove the soundness of our protocol. 3. We give evidence that our new variant of knowledge of exponent assumption is in fact plausible. In particular, we show that our assumption holds in the generic group model. 4. Knowledge assumptions are especially delicate assumptions whose plausibility may be hard to gauge. We give a novel framework to express knowledge assumptions in a more flexible way, which may allow for formulation of plausible assumptions and exploration of their impact and application in cryptography., Comment: 30 pages, 3 figures

Harish K Pemde, Jagdish Chandra, Divya Gupta, Varinder Singh, Rajni Sharma, AK DuttaDepartment of Pediatrics, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, IndiaObjective: To describe physical growth and related factors in transfusion-dependent thalassemia patients.Methods: This is a cross-sectional analysis of the records of the patients registered at and being followed up by the Thalassemia Day Care Center (TDCC) at Kalawati Saran Children's Hospital, New Delhi, India. Clinical and laboratory parameters were recorded on a spreadsheet for analysis. Clinical parameters included weight, height, sexual maturity ratings, and general and systemic physical examination. Laboratory parameters included pretransfusion hemoglobin (Hb), periodic serum ferritin, and tests for viral markers of human immunodeficiency virus (HIV) and hepatitis B and C. Z-scores for weight, height, and body mass index (BMI) were calculated using World Health Organization reference data. Statistical analysis was carried out using Microsoft Excel® and Stata® software.Results: Out of 214 patients registered at the TDCC since 2001, 154 were included in this study. The mean age of patients was 9.19 years (range 0.5–20 years). Pretransfusion Hb was well maintained (mean 9.21 g/dL; 95% confidence interval [CI]: 9.06–9.36), but the mean serum ferritin levels were approximately three times (3112 ng/mL) the desired value despite the patients being on deferiprone (72%) or deferasirox (25%). One-third (33.11%) of the patients had short stature, 13% were thin, and 10.82% were very thin (BMI z-score <-3). No patient was overweight or obese. Linear regression coefficient showed that for every 1-year increase in age, the mean ferritin value increased by 186.21 pg/mL (95% CI: 143.31–228.27). Height z-scores had significant correlation with mean ferritin levels, whereas correlation with mean pretransfusion Hb was not

Augmented reality provides its user with additional information not available through the natural real-world environment. This additional information displayed to the user potentially poses a risk of perceptual and cognitive load and vision-based difficulties. The presence of real-world objects together with virtual augmenting information requires the user to repeatedly switch eye focus between the two in order to extract information from both environments. Switching eye focus may result in additional time on user tasks and lower task accuracy. Thus, one of the goals of this research was to understand the impact of switching eye focus between real-world and virtual information on user task performance. Secondly, focus depth, which is an important parameter and a depth cue, may affect the user's view of the augmented world. If focus depth is not adjusted properly, it may result in vision-based difficulties and reduce speed, accuracy, and comfort while using an augmented reality display. Thus, the second goal of this thesis was to study the effect of focus depth on task performance in augmented reality systems. In augmented reality environments, real-world and virtual information are found at different distances from the user. To focus at different depths, the user's eye needs to accommodate and converge, which may strain the eye and degrade performance on tasks. However, no research in augmented reality has explored this issue. Hence, the third goal of this thesis was to determine if distance of virtual information from the user impacts task performance. To accomplish these goals, a 3x3x3 within subjects design was used. The experimental task for the study required the user to repeatedly switch eye focus between the virtual text and real-world text. A monocular see-through head- mounted display was used for this research. Results of this study revealed that switching between real-world and virtual information in augmented reality is extremely difficult when informati

The apparently unpredictable nature of epileptic seizures can be devastating for people with epilepsy. Current medical interventions can help 75% of patients while 25% have to live with uncontrolled seizures. This motivates the search for a seizure prediction prototype using electroencephalograms (electrical signals that capture brain activity). The concept of phase synchrony has attracted much attention recently in the context of seizure prediction but is still in need of further study. The basis of our analysis is to track changes in synchrony in brain signals at and before seizure onset. The novel concept in our analysis is the use of unmixed signals as opposed to scalp EEG signals for phase synchrony analysis. The unmixing is performed by a Blind Source Separation technique called Independent component Analysis (ICA). ICA seeks underlying independent source signals from the EEG and it allows multivariate analysis using spatial as well as temporal information inherent to EEG signals. The present study on long-term continuous EEG data sets indicates that the concept of using phase synchronization with ICA may prove useful for predicting seizures.