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1. Covid-19 associated reduction in hypertension-related diagnostic and therapeutic procedures in Excellence Centers of the European Society of Hypertension

Author

Weber, T, Amar, J, de Backer, T, Burkard, T, van der Giet, M, Gosse, P, Januszewicz, A, Kahan, T, Mancia, G, Mayer, C, Muiesan, M, Stergiou, G, Tsioufis, K, Vaisse, B, Kreutz, R, Weber T., Amar J., de Backer T., Burkard T., van der Giet M., Gosse P., Januszewicz A., Kahan T., Mancia G., Mayer C. C., Muiesan M. L., Stergiou G. S., Tsioufis K., Vaisse B., Kreutz R., Weber, T, Amar, J, de Backer, T, Burkard, T, van der Giet, M, Gosse, P, Januszewicz, A, Kahan, T, Mancia, G, Mayer, C, Muiesan, M, Stergiou, G, Tsioufis, K, Vaisse, B, Kreutz, R, Weber T., Amar J., de Backer T., Burkard T., van der Giet M., Gosse P., Januszewicz A., Kahan T., Mancia G., Mayer C. C., Muiesan M. L., Stergiou G. S., Tsioufis K., Vaisse B., and Kreutz R.

Abstract

Background: The Covid-19 pandemic necessitated a decrease in non-Covid-19 related diagnostic and therapeutic procedures in many countries. We explored the impact on tertiary hypertension care. Methods: We conducted an electronic survey regarding 6 key procedures in hypertension care within the Excellence Center network of the European Society of Hypertension. Results: Overall, 54 Excellence Centers from 18 European and 3 non-European countries participated. From 2019 to 2020, there were significant decreases in the median number per centre of ambulatory blood pressure monitorings (ABPM: 544/289 for 2019/2020), duplex ultrasound of renal arteries (Duplex RA: 88.5/55), computed tomographic/magnetic resonance imaging angiography of renal arteries (CT/MRI RA: 66/19.5), percutaneous angioplasties of renal arteries (PTA RA: 5/1), laboratory tests for catecholamines (116/67.5) and for renin/aldosterone (146/83.5) (p < 0.001 for all comparisons, respectively). While reductions in all assessed diagnostic and therapeutic procedures were observed in all annual 3-months periods in the comparisons between 2019 and 2020, the most pronounced reduction occurred between April and June 2020, which was the period of the first wave and the first lockdown in most affected countries. In this period, the median reductions in 2020, as compared to 2019, were 50.7% (ABPM), 47.1% (Duplex RA), 50% (CT/MRI RA), 57.1% (PTA RA), 46.9% (catecholamines) and 41.0% (renin/aldosterone), respectively. Overall differences in reduction between 3-month time intervals were statistically highly significant. Conclusion: Diagnostic and therapeutic procedures related to hypertension were dramatically reduced during the first year of the Covid-19 pandemic, with the largest reduction during the first lockdown. The long-term consequences regarding blood pressure control and, ultimately, cardiovascular events remain to be investigated.

Published
2022

2. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, and Rich, Lisa

Abstract

Background: Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. Methods: PRECISION was a multicentre, blinded, randomised, parallel-group, phase 3 study, which was done in hospitals or research centres in Europe, North America, Asia, and Australia. Patients were eligible for randomisation if their sitting systolic blood pressure was 140 mm Hg or higher despite taking standardised background therapy consisting of three antihypertensive drugs, including a diuretic. The study consisted of three sequential parts: part 1 was the 4-week double-blind, randomised, and placebo-controlled part, in which patients received aprocitentan 12·5 mg, aprocitentan 25 mg, or placebo in a 1:1:1 ratio; part 2 was a 32-week single (patient)-blind part, in which all patients received aprocitentan 25 mg; and part 3 was a 12-week double-blind, randomised, and placebo-controlled withdrawal part, in which patients were re-randomised to aprocitentan 25 mg or placebo in a 1:1 ratio. The primary and key secondary endpoints were changes in unattended office systolic blood pressure from baseline to week 4 and from withdrawal baseline to week 40, respectively. Secondary endpoints included 24-h ambulatory blood pressure changes. The study is registered on ClinicalTrials.gov, NCT03541174. Findings: The PRECISION study was done from June 18, 2018, to April 25, 2022. 1965 individuals were screened and 730 were randomly assigned. Of these 730 patients, 704 (96%) completed part 1 of the study; of these, 613 (87%) completed part 2 and, of these, 577 (94%) completed part 3 of the study. The least square m

Published
2022

3. Making 'Sense' of Science.

Author

Gosse, Bonnie

Abstract

Addresses the need for a good science program to teach students to integrate both the analytical and the creative pathways of inquiry. Also compares the specific functions of the brain's right (creative) and left (analytical) hemispheres as related to science. Suggests how to design a creative sense-gathering activity, and offers several sample activities. (AIM)

Published
1996

4. Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension

Author

Parati, G, Stergiou, G, Bilo, G, Kollias, A, Pengo, M, Ochoa, J, Agarwal, R, Asayama, K, Asmar, R, Burnier, M, De La Sierra, A, Giannattasio, C, Gosse, P, Head, G, Hoshide, S, Imai, Y, Kario, K, Li, Y, Manios, E, Mant, J, Mcmanus, R, Mengden, T, Mihailidou, A, Muntner, P, Myers, M, Niiranen, T, Ntineri, A, O'Brien, E, Octavio, J, Ohkubo, T, Omboni, S, Padfield, P, Palatini, P, Pellegrini, D, Postel-Vinay, N, Ramirez, A, Sharman, J, Shennan, A, Silva, E, Topouchian, J, Torlasco, C, Wang, J, Weber, M, Whelton, P, White, W, Mancia, G, Parati, Gianfranco, Stergiou, George S, Bilo, Grzegorz, Kollias, Anastasios, Pengo, Martino, Ochoa, Juan Eugenio, Agarwal, Rajiv, Asayama, Kei, Asmar, Roland, Burnier, Michel, De La Sierra, Alejandro, Giannattasio, Cristina, Gosse, Philippe, Head, Geoffrey, Hoshide, Satoshi, Imai, Yutaka, Kario, Kazuomi, Li, Yan, Manios, Efstathios, Mant, Jonathan, McManus, Richard J, Mengden, Thomas, Mihailidou, Anastasia S, Muntner, Paul, Myers, Martin, Niiranen, Teemu, Ntineri, Angeliki, O'Brien, Eoin, Octavio, José Andres, Ohkubo, Takayoshi, Omboni, Stefano, Padfield, Paul, Palatini, Paolo, Pellegrini, Dario, Postel-Vinay, Nicolas, Ramirez, Agustin J, Sharman, James E, Shennan, Andrew, Silva, Egle, Topouchian, Jirar, Torlasco, Camilla, Wang, Ji Guang, Weber, Michael A, Whelton, Paul K, White, William B, Mancia, Giuseppe, Parati, G, Stergiou, G, Bilo, G, Kollias, A, Pengo, M, Ochoa, J, Agarwal, R, Asayama, K, Asmar, R, Burnier, M, De La Sierra, A, Giannattasio, C, Gosse, P, Head, G, Hoshide, S, Imai, Y, Kario, K, Li, Y, Manios, E, Mant, J, Mcmanus, R, Mengden, T, Mihailidou, A, Muntner, P, Myers, M, Niiranen, T, Ntineri, A, O'Brien, E, Octavio, J, Ohkubo, T, Omboni, S, Padfield, P, Palatini, P, Pellegrini, D, Postel-Vinay, N, Ramirez, A, Sharman, J, Shennan, A, Silva, E, Topouchian, J, Torlasco, C, Wang, J, Weber, M, Whelton, P, White, W, Mancia, G, Parati, Gianfranco, Stergiou, George S, Bilo, Grzegorz, Kollias, Anastasios, Pengo, Martino, Ochoa, Juan Eugenio, Agarwal, Rajiv, Asayama, Kei, Asmar, Roland, Burnier, Michel, De La Sierra, Alejandro, Giannattasio, Cristina, Gosse, Philippe, Head, Geoffrey, Hoshide, Satoshi, Imai, Yutaka, Kario, Kazuomi, Li, Yan, Manios, Efstathios, Mant, Jonathan, McManus, Richard J, Mengden, Thomas, Mihailidou, Anastasia S, Muntner, Paul, Myers, Martin, Niiranen, Teemu, Ntineri, Angeliki, O'Brien, Eoin, Octavio, José Andres, Ohkubo, Takayoshi, Omboni, Stefano, Padfield, Paul, Palatini, Paolo, Pellegrini, Dario, Postel-Vinay, Nicolas, Ramirez, Agustin J, Sharman, James E, Shennan, Andrew, Silva, Egle, Topouchian, Jirar, Torlasco, Camilla, Wang, Ji Guang, Weber, Michael A, Whelton, Paul K, White, William B, and Mancia, Giuseppe

Abstract

The present paper provides an update of previous recommendations on Home Blood Pressure Monitoring from the European Society of Hypertension (ESH) Working Group on Blood Pressure Monitoring and Cardiovascular Variability sequentially published in years 2000, 2008 and 2010. This update has taken into account new evidence in this field, including a recent statement by the American Heart association, as well as technological developments, which have occurred over the past 20 years. The present document has been developed by the same ESH Working Group with inputs from an international team of experts, and has been endorsed by the ESH.

Published
2021

5. Efficacité d'un seuil artificiel sur l'oxygénation de l'eau et l'élimination de CH4 contenu dans l'eau évacuée par la barrage hydroélectrique de Petit Saut (Guyane française)

Author

Richard, S., Grégoire, A., Gosse, P., Richard, S., Grégoire, A., and Gosse, P.

Abstract

Quelques mois après le début de la mise en eau du barrage de Petit Saut, la mise en service normale de l'usine conduisait à une désoxygénation de l'eau du tronçon de rivière aval, le rendant incompatible avec la vie aquatique. La solution retenue a été la construction d'un seuil, afin d'apporter de l'oxygène et d'éliminer les gaz réducteurs produits au fond de la retenue, notamment le méthane, consommateur potentiel d'oxygène dissous.Un seuil métallique à deux lames déversantes successives a été construit ; sa configuration prend en compte les principaux critères physiques jouant un rôle significatif sur l'oxygénation de l'eau (hauteur de chute, épaisseur de la lame déversante, le dimensionnement du bassin de réception des chutes, la présence de dispositifs favorisant l'éclatement de la lame d'eau). Placé dans le canal de fuite de l'usine, à une centaine de mètres à l'aval du barrage principal, il est à l'abri des crues et ne crée pas d'obstacle supplémentaire en rivière.L'article chiffre l'effet d'aération de ce seuil pour les deux gaz O2 et CH4 dans deux configurations : celles consécutives à l'abaissement partiel de la chute amont réalisé en deux étapes. Après décembre 2001, pour le débit moyen turbiné (près de 200 m3 /s), l'efficacité d'aération du seuil a baissé de près de 10 % (gain de 80 % en oxygène dissous et élimination de 70 % et 75 % du méthane dissous). Après février 2003, pour un débit de 100 m3/s, 75 % du déficit amont en oxygène dissous est comblé et près de 70 % du méthane dissous éliminé., From the moment tropical reservoirs are impounded, climatic conditions cause rapid (within several weeks) and marked thermal stratification, especially during the dry season. This phenomenon is further exacerbated by the chemical and biochemical processes taking place in the reservoir due to the decomposition of submerged organic matter. In dense tropical forests, the overhead biomass is estimated at roughly 170 t(C)/ha, and the carbon contained in the soil is also not negligible since it is on the order of 100 t(C)/ha. The degree of biodegradability of the different compounds in the flooded biomass is variable, ranging from a few weeks for bacteria to several centuries for tree trunks.The studies carried out at Petit Saut (French Guiana) show that, immediately after impoundment, only the epilimnion (a few dozen centimetres thick) was oxygenated whereas the hypolimnion was characterized by complete anoxia and a very high methane content (about 15 mg/L). Water quality in the river downstream from the reservoir was of course strongly linked to variations in the water quality in the reservoir as well as to its operating mode. The waters passing through the turbines, coming from the bottom layers, were anoxic and loaded with fixed or volatile reducing compounds (e.g., CH4, H2 S), and were responsible for a high immediate or progressive oxygen demand. At Petit Saut, despite an inflow of good quality water, there has been a progressive deoxygenation in the river downstream due to the high methane content (roughly 8 mg/L) of the turbined water. Thus, 40 km downstream from the dam, the oxygen content was less than 2 mg/L and therefore incompatible with most aquatic life. To solve this problem, it was necessary to build an aerating weir capable of reoxygenating the turbined waters and, more importantly, eliminating reducing gases such as methane at the same time. The function of the overflow weir was to entrain air bubbles into the water and to give these bubbles a sufficien

Published
2005
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6. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaullos

Author

Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel S.I, 1649-1728, Lombard, Daniel, Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel S.I, 1649-1728, and Lombard, Daniel

Abstract

Mención de edición precede a número de tomo, Sign.: []\p2\s, A-Q\p12\s, a-l\p12\s, m\p8\s

7. Abregé de l'histoire universelle ...

Author

Gosse, P, imp, Neaulme, J, imp, Delisle, Claude, 1644-1720, Gosse, P, imp, Neaulme, J, imp, and Delisle, Claude, 1644-1720

Abstract

Sign.: a-b\p8/2\s, A-Z\p8/4\s, 2A-2M\p8/4\s, Port. a dos tintas con grab. xil, Las h. de mapas son xil, Cabeceras xil, Letra capital

8. Abregé de l'histoire universelle ...

Author

Gosse, P, imp, Neaulme, imp, Delisle, Claude, 1644-1720, Gosse, P, imp, Neaulme, imp, and Delisle, Claude, 1644-1720

Abstract

Sign.: A-Z\p8/4\s, 2A-2M\p8/4\s, a\p8\s, Port. a dos tintas con grab. xil, Cabeceras con grab. xil, Letra capital

9. Histoire de France depuis l'établissment de la monarchie françoise dans les Gaules

Author

Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel , (S.l.), Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Sign.: [ ]\p2\s, A-Z\p12\s, 2A-2B\p12\s, Antep, Port. a dúas tintas con grav. xil, Texto con apost. marx

10. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaules

Author

Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Daniel, Gabriel , (S.l.), Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Mención de ed. precede o tomo, Sign.: A-Z\p12\s, 2A-2B\p12/6\s, 2C\p3\s, Port. a dúas tintas e con grav. xil, Texto con apostilas marx

11. Histoire de France depuis l'établissment de la monarchie françoise dans les Gaules

Author

Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel , (S.l.), Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Sign.: [ ]\p1\s, A-Z\p12\s, 2A\p12\s, Antep, Port. a dúas tintas e grav. xil, Texto con apostilas marxinais

12. Histoire de France depuis l'établissment de la monarchie françoise dans les Gaules

Author

Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel , (S.l.), Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Sign.: [ ]\p2\s, A-Z\p12\s, 2A-2B\p12\s, 2C\p2\s, Antep, Port. a dúas tintas con grav. xil, Texto con apost. marx

13. Histoire de France depuis l'établissment de la monarchie françoise dans les Gaules

Author

Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel , (S.l.), Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Sign.: [ ]\p2\s, A-Z\p12\s, 2Ap12\s, Antep, Port. a dúas tintas con grav. xil, Texto con apost. marx

14. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaules

Author

Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Daniel, Gabriel , (S.l.), Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Mención de ed. precede o tomo, Sign.: A-Z\p12\s, 2A\p12\s, 2B\p10\s, Port. a dúas tintas e con grav. xil, Texto con apostilas marx

15. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaules

Author

Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Daniel, Gabriel , (S.l.), Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Mención de ed. precede o tomo, Sign.: [sol] \p12\s, a-e\p12\s, f\p1\s, A-T\p12\s, V\p11\s, Port. a dúas tintas e con grav. xil, Texto con apostilas marx, As f. de grav. calc

16. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaules

Author

Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Daniel, Gabriel , (S.I.), Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, and Daniel, Gabriel , (S.I.)

Abstract

Mención de ed. precede o tomo, Sign.: A-Z\p12\s, 2A\p12\s, 2B\p8/s, Port. a dúas tintas e con grav. xil, Texto con apostilas marx

17. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaules

Author

Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Daniel, Gabriel , (S.I.), Changuion, Fr, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, and Daniel, Gabriel , (S.I.)

Abstract

Mención de ed. precede o tomo, Sign.: A-Z\p12\s, 2A-2B\p12/6\s, 2C\p3\s, Port. a dúas tintas e con grav. xil, Texto con apostilas marx

18. Histoire de France depuis l'etablissement de la Monarchie Françoise dans les Gaules

Author

Changuion, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Daniel, Gabriel , (S.I.), Changuion, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, and Daniel, Gabriel , (S.I.)

Abstract

Mención de ed. precede o tomo, Sign.: A-Z\p12\s, 2A-2B\p12, Port. a dúas tintas e con grav. xil, Texto con apostilas marx

19. Histoire de France depuis l'établissment de la monarchie françoise dans les Gaules

Author

Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, Daniel, Gabriel , (S.l.), Changuion, François, ed. lit, Catuffe, J, ed. lit, Uytwerf, François, ed. lit, Gosse, P, ed. lit, Neaulme, Jean, ed. lit, Moetjens, Adrian, ed. lit, Dole, A. van, ed. lit, Neaulme, E, ed. lit, and Daniel, Gabriel , (S.l.)

Abstract

Sign.: [ ]\p2\s, A-Z\p12\s, 2A-2Bp12\s, Antep, Port. a dúas tintas con grav. xil, Texto con apost. marx

20. Abregé de l'histoire universelle;...

Author

Gosse, P, imp, Neaulme, J, imp, L'Isle, Claude de, Gosse, P, imp, Neaulme, J, imp, and L'Isle, Claude de

Abstract

Sign.:a8, b4, A-Z8/4, 2A-2R8/4, Antep, Port. a dos tintas conn grab. calc, Cabecera con grab. xil, Letra capital, Il. grab. xil. pleg. de mapa

21. Abregé de l'histoire universelle;...

Author

Gosse,P, imp, Neaulme, J, imp, L'Isle, Claude de, Gosse,P, imp, Neaulme, J, imp, and L'Isle, Claude de

Abstract

Sign.:a-b8/2, A-Z8/4, 2A-2M8/4, Enc. en piel con nervios y hierros dorados , con cortes colorados, Port. a dos tintas con grab. xil, Grab. de mapas xil, Cabeceras xil, Letra capital

22. Abregé de l'histoire universelle;...

Author

Gosse, P, imp, Neaulme, imp, L'Isle, Claude de, Gosse, P, imp, Neaulme, imp, and L'Isle, Claude de

Abstract

Sign.:A-Z8/4, 2A-2M8/4, a8, Port. a dos tintas con grab. xil, Cabeceras con grab. xil, Letra capital, Sign., alterna: 8-4

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