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13 results on '"Gonda T"'

1. Achieving stationary high performance plasmas at Wendelstein 7-X

Author

Langenberg, A., Warmer, F., Fuchert, G., Ford, O., Bozhenkov, S., Andreeva, T., Lazerson, S., Pablant, N. A., Gonda, T., Beurskens, M. N.A., Brunner, K. J., Buttenschön, B., Dinklage, A., Hartmann, D., Knauer, J., Marchuk, O., Pasch, E., Reimold, F., Stange, T., Wegner, Th, Grulke, O., Wolf, R. C., Langenberg, A., Warmer, F., Fuchert, G., Ford, O., Bozhenkov, S., Andreeva, T., Lazerson, S., Pablant, N. A., Gonda, T., Beurskens, M. N.A., Brunner, K. J., Buttenschön, B., Dinklage, A., Hartmann, D., Knauer, J., Marchuk, O., Pasch, E., Reimold, F., Stange, T., Wegner, Th, Grulke, O., and Wolf, R. C.

Abstract

This work reports on recent results on the search for high performance plasma scenarios at the magnetically confined stellarator fusion device Wendelstein 7-X. In four new designed scenarios, the development from transient toward stationary plasmas of improved performance has been realized. In particular, a high performance duration of up to 5 s, an energy confinement time of 0.3 s, a diamagnetic energy of 1.1 MJ, a central ion temperature of 2.2 keV, and a fusion triple product of 3.4 × 10 19 m − 3 · keV · s have been achieved, and previously observed limitations of the machine have been overcome, regarding both the performance and its duration. The two main experimental techniques for stationary high performance are neutral beam injection core fueling on the one hand and the use of a magnetic field configuration with internal islands on the other hand. Two of the developed scenarios are expected to be extendable straightforward toward a duration of several tens of seconds, making use of the long pulse operation capabilities of W7-X.

Published
2024

2. Advanced endoscopy meets molecular diagnosis of cholangiocarcinoma

Author

Cadamuro, M, Al-Taee, A, Gonda, T, Gonda, TA, Cadamuro, M, Al-Taee, A, Gonda, T, and Gonda, TA

Abstract

Cholangiocarcinoma remains an aggressive and deadly malignancy that is often diagnosed late. Intrinsic tumour characteristics and the growth pattern of cancer cells contribute to the challenges of diagnosis and chemoresistance. However, establishing an early and accurate diagnosis, and in some instances identifying targetable changes, has the potential to impact survival. Primary sclerosing cholangitis, a chronic cholangiopathy prodromal to the development of a minority of cholangiocarcinomas, poses a particular diagnostic challenge. We present our diagnostic and theranostic approach to the initial evaluation of cholangiocarcinomas, focusing on extrahepatic cholangiocarcinoma. This involves a multipronged strategy incorporating advanced imaging, endoscopic methods, multiple approaches to tissue sampling, and molecular markers. We also provide an algorithm for the sequential use of these tools. (c) 2023 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Published
2023

3. Design and production of the high voltage electrode grids and electron extraction region for the LZ dual-phase xenon time projection chamber

Author

Linehan, R., Mannino, R. L., Fan, A., Ignarra, C. M., Luitz, S., Skarpaas, K., Shutt, T. A., Akerib, D. S., Alsum, S. K., Anderson, T. J., Araújo, H. M., Arthurs, M., Auyeung, H., Bailey, A. J., Biesiadzinski, T. P., Breidenbach, M., Cherwinka, J. J., Conley, R. A., Genovesi, J., Gilchriese, M. G. D., Glaenzer, A., Gonda, T. G., Hanzel, K., Hoff, M. D., Ji, W., Kaboth, A. C., Kravitz, S., Kurita, N. R., Lambert, A. R., Lesko, K. T., Lorenzon, W., Majewski, P. A., Miller, E. H., Monzani, M. E., Palladino, K. J., Ratcliff, B. N., Saba, J. S., Santone, D., Shutt, G. W., Stifter, K., Szydagis, M., Tomás, A., Va'vra, J., Waldron, W. L., Webb, R. C., White, R. G., Whitis, T. J., Wilson, K., Wisniewski, W. J., Linehan, R., Mannino, R. L., Fan, A., Ignarra, C. M., Luitz, S., Skarpaas, K., Shutt, T. A., Akerib, D. S., Alsum, S. K., Anderson, T. J., Araújo, H. M., Arthurs, M., Auyeung, H., Bailey, A. J., Biesiadzinski, T. P., Breidenbach, M., Cherwinka, J. J., Conley, R. A., Genovesi, J., Gilchriese, M. G. D., Glaenzer, A., Gonda, T. G., Hanzel, K., Hoff, M. D., Ji, W., Kaboth, A. C., Kravitz, S., Kurita, N. R., Lambert, A. R., Lesko, K. T., Lorenzon, W., Majewski, P. A., Miller, E. H., Monzani, M. E., Palladino, K. J., Ratcliff, B. N., Saba, J. S., Santone, D., Shutt, G. W., Stifter, K., Szydagis, M., Tomás, A., Va'vra, J., Waldron, W. L., Webb, R. C., White, R. G., Whitis, T. J., Wilson, K., and Wisniewski, W. J.

Abstract

The dual-phase xenon time projection chamber (TPC) is a powerful tool for direct-detection experiments searching for WIMP dark matter, other dark matter models, and neutrinoless double-beta decay. Successful operation of such a TPC is critically dependent on the ability to hold high electric fields in the bulk liquid, across the liquid surface, and in the gas. Careful design and construction of the electrodes used to establish these fields is therefore required. We present the design and production of the LUX-ZEPLIN (LZ) experiment's high-voltage electrodes, a set of four woven mesh wire grids. Grid design drivers are discussed, with emphasis placed on design of the electron extraction region. We follow this with a description of the grid production process and a discussion of steps taken to validate the LZ grids prior to integration into the TPC., Comment: 23 pages, 20 figures, to be submitted to Nuclear Instruments and Methods in Physics Research Section A. Corresponding authors: rlinehan@stanford.edu and mannino2@wisc.edu

Published
2021

4. Design and production of the high voltage electrode grids and electron extraction region for the LZ dual-phase xenon time projection chamber

Author

Linehan, R., Mannino, R. L., Fan, A., Ignarra, C. M., Luitz, S., Skarpaas, K., Shutt, T. A., Akerib, D. S., Alsum, S. K., Anderson, T. J., Araújo, H. M., Arthurs, M., Auyeung, H., Bailey, A. J., Biesiadzinski, T. P., Breidenbach, M., Cherwinka, J. J., Conley, R. A., Genovesi, J., Gilchriese, M. G. D., Glaenzer, A., Gonda, T. G., Hanzel, K., Hoff, M. D., Ji, W., Kaboth, A. C., Kravitz, S., Kurita, N. R., Lambert, A. R., Lesko, K. T., Lorenzon, W., Majewski, P. A., Miller, E. H., Monzani, M. E., Palladino, K. J., Ratcliff, B. N., Saba, J. S., Santone, D., Shutt, G. W., Stifter, K., Szydagis, M., Tomás, A., Va'vra, J., Waldron, W. L., Webb, R. C., White, R. G., Whitis, T. J., Wilson, K., Wisniewski, W. J., Linehan, R., Mannino, R. L., Fan, A., Ignarra, C. M., Luitz, S., Skarpaas, K., Shutt, T. A., Akerib, D. S., Alsum, S. K., Anderson, T. J., Araújo, H. M., Arthurs, M., Auyeung, H., Bailey, A. J., Biesiadzinski, T. P., Breidenbach, M., Cherwinka, J. J., Conley, R. A., Genovesi, J., Gilchriese, M. G. D., Glaenzer, A., Gonda, T. G., Hanzel, K., Hoff, M. D., Ji, W., Kaboth, A. C., Kravitz, S., Kurita, N. R., Lambert, A. R., Lesko, K. T., Lorenzon, W., Majewski, P. A., Miller, E. H., Monzani, M. E., Palladino, K. J., Ratcliff, B. N., Saba, J. S., Santone, D., Shutt, G. W., Stifter, K., Szydagis, M., Tomás, A., Va'vra, J., Waldron, W. L., Webb, R. C., White, R. G., Whitis, T. J., Wilson, K., and Wisniewski, W. J.

Abstract

The dual-phase xenon time projection chamber (TPC) is a powerful tool for direct-detection experiments searching for WIMP dark matter, other dark matter models, and neutrinoless double-beta decay. Successful operation of such a TPC is critically dependent on the ability to hold high electric fields in the bulk liquid, across the liquid surface, and in the gas. Careful design and construction of the electrodes used to establish these fields is therefore required. We present the design and production of the LUX-ZEPLIN (LZ) experiment's high-voltage electrodes, a set of four woven mesh wire grids. Grid design drivers are discussed, with emphasis placed on design of the electron extraction region. We follow this with a description of the grid production process and a discussion of steps taken to validate the LZ grids prior to integration into the TPC., Comment: 23 pages, 20 figures, to be submitted to Nuclear Instruments and Methods in Physics Research Section A. Corresponding authors: rlinehan@stanford.edu and mannino2@wisc.edu

Published
2021
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5. Design and production of the high voltage electrode grids and electron extraction region for the LZ dual-phase xenon time projection chamber

Author

Linehan, R., Mannino, R. L., Fan, A., Ignarra, C. M., Luitz, S., Skarpaas, K., Shutt, T. A., Akerib, D. S., Alsum, S. K., Anderson, T. J., Araújo, H. M., Arthurs, M., Auyeung, H., Bailey, A. J., Biesiadzinski, T. P., Breidenbach, M., Cherwinka, J. J., Conley, R. A., Genovesi, J., Gilchriese, M. G. D., Glaenzer, A., Gonda, T. G., Hanzel, K., Hoff, M. D., Ji, W., Kaboth, A. C., Kravitz, S., Kurita, N. R., Lambert, A. R., Lesko, K. T., Lorenzon, W., Majewski, P. A., Miller, E. H., Monzani, M. E., Palladino, K. J., Ratcliff, B. N., Saba, J. S., Santone, D., Shutt, G. W., Stifter, K., Szydagis, M., Tomás, A., Va'vra, J., Waldron, W. L., Webb, R. C., White, R. G., Whitis, T. J., Wilson, K., Wisniewski, W. J., Linehan, R., Mannino, R. L., Fan, A., Ignarra, C. M., Luitz, S., Skarpaas, K., Shutt, T. A., Akerib, D. S., Alsum, S. K., Anderson, T. J., Araújo, H. M., Arthurs, M., Auyeung, H., Bailey, A. J., Biesiadzinski, T. P., Breidenbach, M., Cherwinka, J. J., Conley, R. A., Genovesi, J., Gilchriese, M. G. D., Glaenzer, A., Gonda, T. G., Hanzel, K., Hoff, M. D., Ji, W., Kaboth, A. C., Kravitz, S., Kurita, N. R., Lambert, A. R., Lesko, K. T., Lorenzon, W., Majewski, P. A., Miller, E. H., Monzani, M. E., Palladino, K. J., Ratcliff, B. N., Saba, J. S., Santone, D., Shutt, G. W., Stifter, K., Szydagis, M., Tomás, A., Va'vra, J., Waldron, W. L., Webb, R. C., White, R. G., Whitis, T. J., Wilson, K., and Wisniewski, W. J.

Abstract

The dual-phase xenon time projection chamber (TPC) is a powerful tool for direct-detection experiments searching for WIMP dark matter, other dark matter models, and neutrinoless double-beta decay. Successful operation of such a TPC is critically dependent on the ability to hold high electric fields in the bulk liquid, across the liquid surface, and in the gas. Careful design and construction of the electrodes used to establish these fields is therefore required. We present the design and production of the LUX-ZEPLIN (LZ) experiment's high-voltage electrodes, a set of four woven mesh wire grids. Grid design drivers are discussed, with emphasis placed on design of the electron extraction region. We follow this with a description of the grid production process and a discussion of steps taken to validate the LZ grids prior to integration into the TPC., Comment: 23 pages, 20 figures, to be submitted to Nuclear Instruments and Methods in Physics Research Section A. Corresponding authors: rlinehan@stanford.edu and mannino2@wisc.edu

Published
2021
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6. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Aviles, S., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Brew, C. A. J., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Cabrita, R., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Cox, G., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunhaw, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Fraser, E. D., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Harrison, J., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Kodroff, D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Lopez-Asamar, E., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, W., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., Zarzhitsky, P., Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Aviles, S., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Brew, C. A. J., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Cabrita, R., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Cox, G., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunhaw, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Fraser, E. D., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Harrison, J., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Kodroff, D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Lopez-Asamar, E., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, W., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., and Zarzhitsky, P.

Abstract

LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $1.4 \times 10^{-48}$ cm$^{2}$ for a WIMP mass of 40 GeV/c$^{2}$ and a 1000 d exposure. LZ achieves this sensitivity through a combination of a large 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented., Comment: 45 pages (79 inc. tables), 7 figures, 9 tables

Published
2020
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7. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry.

Author

Smith, MS, Smith, MS, Cash, B, Konda, V, Trindade, AJ, Gordon, S, DeMeester, S, Joshi, V, Diehl, D, Ganguly, E, Mashimo, H, Singh, S, Jobe, B, McKinley, M, Wallace, M, Komatsu, Y, Thakkar, S, Schnoll-Sussman, F, Sharaiha, R, Kahaleh, M, Tarnasky, P, Wolfsen, H, Hawes, R, Lipham, J, Khara, H, Pleskow, D, Navaneethan, U, Kedia, P, Hasan, M, Sethi, A, Samarasena, J, Siddiqui, UD, Gress, F, Rodriguez, R, Lee, C, Gonda, T, Waxman, I, Hyder, S, Poneros, J, Sharzehi, K, Di Palma, JA, Sejpal, DV, Oh, D, Hagen, J, Rothstein, R, Sawhney, M, Berzin, T, Malik, Z, Chang, K, Smith, MS, Smith, MS, Cash, B, Konda, V, Trindade, AJ, Gordon, S, DeMeester, S, Joshi, V, Diehl, D, Ganguly, E, Mashimo, H, Singh, S, Jobe, B, McKinley, M, Wallace, M, Komatsu, Y, Thakkar, S, Schnoll-Sussman, F, Sharaiha, R, Kahaleh, M, Tarnasky, P, Wolfsen, H, Hawes, R, Lipham, J, Khara, H, Pleskow, D, Navaneethan, U, Kedia, P, Hasan, M, Sethi, A, Samarasena, J, Siddiqui, UD, Gress, F, Rodriguez, R, Lee, C, Gonda, T, Waxman, I, Hyder, S, Poneros, J, Sharzehi, K, Di Palma, JA, Sejpal, DV, Oh, D, Hagen, J, Rothstein, R, Sawhney, M, Berzin, T, Malik, Z, and Chang, K

Abstract

Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE procedure, investigators were asked to answer six key questions regarding how VLE impacted each case. Statistical analyses including neoplasia diagnostic yield improvement using VLE was performed. One thousand patients were enrolled across 18 US trial sites from August 2014 through April 2016. In patients with previously diagnosed or suspected BE (894/1000), investigators used VLE and identified areas of concern not seen on white light endoscopy (WLE) in 59% of the procedures. VLE imaging also guided tissue acquisition and treatment in 71% and 54% of procedures, respectively. VLE as an adjunct modality improved the neoplasia diagnostic yield by 55% beyond the standard of care practice. In patients with no prior history of therapy, and without visual findings from other technologies, VLE-guided tissue acquisition increased neoplasia detection over random biopsies by 700%. Registry investigators reported that VLE improved the BE management process when used as an adjunct tissue acquisition and treatment guidance tool. The ability of VLE to image large segments of the esophagus with microscopic cross-sectional detail may provide additional benefits including higher yield biopsies and more efficient tissue acquisition. Clinicaltrials.gov NCT02215291.

Published
2019

8. The LUX-ZEPLIN (LZ) Experiment

Author

The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., and Zhang, C.

Abstract

We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements.

Published
2019
Full Text
View/download PDF

9. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry.

Author

Smith, MS, Smith, MS, Cash, B, Konda, V, Trindade, AJ, Gordon, S, DeMeester, S, Joshi, V, Diehl, D, Ganguly, E, Mashimo, H, Singh, S, Jobe, B, McKinley, M, Wallace, M, Komatsu, Y, Thakkar, S, Schnoll-Sussman, F, Sharaiha, R, Kahaleh, M, Tarnasky, P, Wolfsen, H, Hawes, R, Lipham, J, Khara, H, Pleskow, D, Navaneethan, U, Kedia, P, Hasan, M, Sethi, A, Samarasena, J, Siddiqui, UD, Gress, F, Rodriguez, R, Lee, C, Gonda, T, Waxman, I, Hyder, S, Poneros, J, Sharzehi, K, Di Palma, JA, Sejpal, DV, Oh, D, Hagen, J, Rothstein, R, Sawhney, M, Berzin, T, Malik, Z, Chang, K, Smith, MS, Smith, MS, Cash, B, Konda, V, Trindade, AJ, Gordon, S, DeMeester, S, Joshi, V, Diehl, D, Ganguly, E, Mashimo, H, Singh, S, Jobe, B, McKinley, M, Wallace, M, Komatsu, Y, Thakkar, S, Schnoll-Sussman, F, Sharaiha, R, Kahaleh, M, Tarnasky, P, Wolfsen, H, Hawes, R, Lipham, J, Khara, H, Pleskow, D, Navaneethan, U, Kedia, P, Hasan, M, Sethi, A, Samarasena, J, Siddiqui, UD, Gress, F, Rodriguez, R, Lee, C, Gonda, T, Waxman, I, Hyder, S, Poneros, J, Sharzehi, K, Di Palma, JA, Sejpal, DV, Oh, D, Hagen, J, Rothstein, R, Sawhney, M, Berzin, T, Malik, Z, and Chang, K

Abstract

Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE procedure, investigators were asked to answer six key questions regarding how VLE impacted each case. Statistical analyses including neoplasia diagnostic yield improvement using VLE was performed. One thousand patients were enrolled across 18 US trial sites from August 2014 through April 2016. In patients with previously diagnosed or suspected BE (894/1000), investigators used VLE and identified areas of concern not seen on white light endoscopy (WLE) in 59% of the procedures. VLE imaging also guided tissue acquisition and treatment in 71% and 54% of procedures, respectively. VLE as an adjunct modality improved the neoplasia diagnostic yield by 55% beyond the standard of care practice. In patients with no prior history of therapy, and without visual findings from other technologies, VLE-guided tissue acquisition increased neoplasia detection over random biopsies by 700%. Registry investigators reported that VLE improved the BE management process when used as an adjunct tissue acquisition and treatment guidance tool. The ability of VLE to image large segments of the esophagus with microscopic cross-sectional detail may provide additional benefits including higher yield biopsies and more efficient tissue acquisition. Clinicaltrials.gov NCT02215291.

Published
2019

10. The LUX-ZEPLIN (LZ) Experiment

Author

The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., and Zhang, C.

Abstract

We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements.

Published
2019
Full Text
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11. The LUX-ZEPLIN (LZ) Experiment

Author

The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. 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Abstract

We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements.

Published
2019
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12. MYB elongation is regulated by the nucleic acid binding of NFekB p50 to the intronic stem-loop region

Author

Pereira, L., Hugo, H., Malaterre, J., Huiling, X., Sonza, S., Cures, A., Purcell, D., Ramsland, Paul, Gerondakis, S., Gonda, T., Ramsay, R., Pereira, L., Hugo, H., Malaterre, J., Huiling, X., Sonza, S., Cures, A., Purcell, D., Ramsland, Paul, Gerondakis, S., Gonda, T., and Ramsay, R.

Abstract

MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem loop (SLR) followed by a polyU tract. We report that NFekBp50 can bind the SLR polyU RNA and promote MYB transcriptional elongation together with NFekBp65. We identified a conserved lysine-rich motif within the Rel homology domain (RHD) of NFekBp50, mutation of which abrogated the interaction of NFekBp50 with the SLR polyU and impaired NFekBp50 mediated MYB elongation. We observed that the TAR RNA-binding region of Tat is homologous to the NFekBp50 RHD lysine-rich motif, a finding consistent with HIV Tat acting as an effector of MYB transcriptional elongation in an SLR dependent manner. Furthermore, we identify the DNA binding activity of NFekBp50 as a key component required for the SLR polyU mediated regulation of MYB. Collectively these results suggest that the MYB SLR polyU provides a platform for proteins to regulate MYB and reveals novel nucleic acid binding properties of NFekBp50 required for MYB regulation.

Published
2015

13. Myb-Binding Protein 1A (MYBBP1A) Is Essential for Early Embryonic Development, Controls Cell Cycle and Mitosis, and Acts as a Tumor Suppressor

Author

Mori, S, Bernardi, R, Laurent, A, Resnati, M, Crippa, A, Gabrieli, A, Keough, R, Gonda, T, Blasi, F, MORI, SILVIA, Blasi, F., Mori, S, Bernardi, R, Laurent, A, Resnati, M, Crippa, A, Gabrieli, A, Keough, R, Gonda, T, Blasi, F, MORI, SILVIA, and Blasi, F.

Abstract

MYBBP1A is a predominantly nucleolar transcriptional regulator involved in rDNA synthesis and p53 activation via acetylation. However little further information is available as to its function. Here we report that MYBBP1A is developmentally essential in the mouse prior to blastocyst formation. In cell culture, down-regulation of MYBBP1A decreases the growth rate of wild type mouse embryonic stem cells, mouse embryo fibroblasts (MEFs) and of human HeLa cells, where it also promotes apoptosis. HeLa cells either arrest at G2/M or undergo delayed and anomalous mitosis. At mitosis, MYBBP1A is localized to a parachromosomal region and gene-expression profiling shows that its down-regulation affects genes controlling chromosomal segregation and cell cycle. However, MYBBP1A down-regulation increases the growth rate of the immortalized NIH3T3 cells. Such Mybbp1a down-regulated NIH3T3 cells are more susceptible to Ras-induced transformation and cause more potent Ras-driven tumors. We conclude that MYBBP1A is an essential gene with novel roles at the pre-mitotic level and potential tumor suppressor activity. © 2012 Mori et al

Published
2012

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