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8 results on '"Gold, Nicholas"'

1. The Scientific Investigation of Unidentified Aerial Phenomena (UAP) Using Multimodal Ground-Based Observatories

Author

Watters, Wesley Andrés, Loeb, Abraham, Laukien, Frank, Cloete, Richard, Delacroix, Alex, Dobroshinsky, Sergei, Horvath, Benjamin, Kelderman, Ezra, Little, Sarah, Masson, Eric, Mead, Andrew, Randall, Mitch, Schultz, Forrest, Szenher, Matthew, Vervelidou, Foteini, White, Abigail, Ahlström, Angelique, Cleland, Carol, Dockal, Spencer, Donahue, Natasha, Elowitz, Mark, Ezell, Carson, Gersznowicz, Alex, Gold, Nicholas, Hercz, Michael G., Keto, Eric, Knuth, Kevin H., Lux, Anthony, Melnick, Gary J., Moro-Martín, Amaya, Martin-Torres, Javier, Ribes, Daniel Llusa, Sail, Paul, Teodorani, Massimo, Tedesco, John Joseph, Tedesco, Gerald Thomas, Tu, Michelle, Zorzano, Maria-Paz, Watters, Wesley Andrés, Loeb, Abraham, Laukien, Frank, Cloete, Richard, Delacroix, Alex, Dobroshinsky, Sergei, Horvath, Benjamin, Kelderman, Ezra, Little, Sarah, Masson, Eric, Mead, Andrew, Randall, Mitch, Schultz, Forrest, Szenher, Matthew, Vervelidou, Foteini, White, Abigail, Ahlström, Angelique, Cleland, Carol, Dockal, Spencer, Donahue, Natasha, Elowitz, Mark, Ezell, Carson, Gersznowicz, Alex, Gold, Nicholas, Hercz, Michael G., Keto, Eric, Knuth, Kevin H., Lux, Anthony, Melnick, Gary J., Moro-Martín, Amaya, Martin-Torres, Javier, Ribes, Daniel Llusa, Sail, Paul, Teodorani, Massimo, Tedesco, John Joseph, Tedesco, Gerald Thomas, Tu, Michelle, and Zorzano, Maria-Paz

Abstract

(Abridged) Unidentified Aerial Phenomena (UAP) have resisted explanation and have received little formal scientific attention for 75 years. A primary objective of the Galileo Project is to build an integrated software and instrumentation system designed to conduct a multimodal census of aerial phenomena and to recognize anomalies. Here we present key motivations for the study of UAP and address historical objections to this research. We describe an approach for highlighting outlier events in the high-dimensional parameter space of our census measurements. We provide a detailed roadmap for deciding measurement requirements, as well as a science traceability matrix (STM) for connecting sought-after physical parameters to observables and instrument requirements. We also discuss potential strategies for deciding where to locate instruments for development, testing, and final deployment. Our instrument package is multimodal and multispectral, consisting of (1) wide-field cameras in multiple bands for targeting and tracking of aerial objects and deriving their positions and kinematics using triangulation; (2) narrow-field instruments including cameras for characterizing morphology, spectra, polarimetry, and photometry; (3) passive multistatic arrays of antennas and receivers for radar-derived range and kinematics; (4) radio spectrum analyzers to measure radio and microwave emissions; (5) microphones for sampling acoustic emissions in the infrasonic through ultrasonic frequency bands; and (6) environmental sensors for characterizing ambient conditions (temperature, pressure, humidity, and wind velocity), as well as quasistatic electric and magnetic fields, and energetic particles. The use of multispectral instruments and multiple sensor modalities will help to ensure that artifacts are recognized and that true detections are corroborated and verifiable., Comment: This paper is published in the Journal of Astronomical Instrumentation, 12(1), 2340006 (2023) https://doi.org/10.1142/S2251171723400068

Published
2023
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2. Building a global alliance of biofoundries.

Author

Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Le Feuvre, Rosalind, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, Freemont, Paul S, Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Le Feuvre, Rosalind, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S

Abstract

Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.

Published
2019

3. Author Correction: Building a global alliance of biofoundries.

Author

Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Feuvre, Rosalind Le, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, Freemont, Paul S, Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Feuvre, Rosalind Le, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S

Abstract

The original version of this Comment contained errors in the legend of Figure 2, in which the locations of the fifteenth and sixteenth GBA members were incorrectly given as '(15) Australian Genome Foundry, Macquarie University; (16) Australian Foundry for Advanced Biomanufacturing, University of Queensland.'. The correct version replaces this with '(15) Australian Foundry for Advanced Biomanufacturing (AusFAB), University of Queensland and (16) Australian Genome Foundry, Macquarie University'. This has been corrected in both the PDF and HTML versions of the Comment.

Published
2019

4. Building a global alliance of biofoundries.

Author

Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Le Feuvre, Rosalind, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, Freemont, Paul S, Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Le Feuvre, Rosalind, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S

Abstract

Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.

Published
2019

5. Author Correction: Building a global alliance of biofoundries.

Author

Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Feuvre, Rosalind Le, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, Freemont, Paul S, Hillson, Nathan, Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A, Chang, Matthew Wook, Curach, Natalie C, Bell, David J, Feuvre, Rosalind Le, Friedman, Douglas C, Fu, Xiongfei, Gold, Nicholas D, Herrgård, Markus J, Holowko, Maciej B, Johnson, James R, Johnson, Richard A, Keasling, Jay D, Kitney, Richard I, Kondo, Akihiko, Liu, Chenli, Martin, Vincent JJ, Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J, Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S, Rosser, Susan J, Scrutton, Nigel S, Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E, Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S

Abstract

The original version of this Comment contained errors in the legend of Figure 2, in which the locations of the fifteenth and sixteenth GBA members were incorrectly given as '(15) Australian Genome Foundry, Macquarie University; (16) Australian Foundry for Advanced Biomanufacturing, University of Queensland.'. The correct version replaces this with '(15) Australian Foundry for Advanced Biomanufacturing (AusFAB), University of Queensland and (16) Australian Genome Foundry, Macquarie University'. This has been corrected in both the PDF and HTML versions of the Comment.

Published
2019

6. Author Correction: Building a global alliance of biofoundries (Nature Communications, (2019), 10, 1, (2040), 10.1038/s41467-019-10079-2)

Author

Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A., Chang, Matthew Wook, Curach, Natalie C., Bell, David J., Feuvre, Rosalind Le, Friedman, Douglas C., Fu, Xiongfei, Gold, Nicholas D., Herrgård, Markus J., Holowko, Maciej B., Johnson, James R., Johnson, Richard A., Keasling, Jay D., Kitney, Richard I., Kondo, Akihiko, Liu, Chenli, Martin, Vincent J.J., Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J., Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S., Rosser, Susan J., Scrutton, Nigel S., Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E., Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, Freemont, Paul S., Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A., Chang, Matthew Wook, Curach, Natalie C., Bell, David J., Feuvre, Rosalind Le, Friedman, Douglas C., Fu, Xiongfei, Gold, Nicholas D., Herrgård, Markus J., Holowko, Maciej B., Johnson, James R., Johnson, Richard A., Keasling, Jay D., Kitney, Richard I., Kondo, Akihiko, Liu, Chenli, Martin, Vincent J.J., Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J., Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S., Rosser, Susan J., Scrutton, Nigel S., Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E., Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S.

Abstract

The original version of this Comment contained errors in the legend of Figure 2, in which the locations of the fifteenth and sixteenth GBA members were incorrectly given as ‘(15) Australian Genome Foundry, Macquarie University; (16) Australian Foundry for Advanced Biomanufacturing, University of Queensland.’. The correct version replaces this with ‘(15) Australian Foundry for Advanced Biomanufacturing (AusFAB), University of Queensland and (16) Australian Genome Foundry, Macquarie University’. This has been corrected in both the PDF and HTML versions of the Comment.

Published
2019

7. Building a global alliance of biofoundries

Author

Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A., Chang, Matthew Wook, Curach, Natalie C., Bell, David J., Le Feuvre, Rosalind, Friedman, Douglas C., Fu, Xiongfei, Gold, Nicholas D., Herrgård, Markus J., Holowko, Maciej B., Johnson, James R., Johnson, Richard A., Keasling, Jay D., Kitney, Richard I., Kondo, Akihiko, Liu, Chenli, Martin, Vincent J.J., Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J., Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S., Rosser, Susan J., Scrutton, Nigel S., Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E., Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, Freemont, Paul S., Hillson, Nathan, Caddick, Mark, Cai, Yizhi, Carrasco, Jose A., Chang, Matthew Wook, Curach, Natalie C., Bell, David J., Le Feuvre, Rosalind, Friedman, Douglas C., Fu, Xiongfei, Gold, Nicholas D., Herrgård, Markus J., Holowko, Maciej B., Johnson, James R., Johnson, Richard A., Keasling, Jay D., Kitney, Richard I., Kondo, Akihiko, Liu, Chenli, Martin, Vincent J.J., Menolascina, Filippo, Ogino, Chiaki, Patron, Nicola J., Pavan, Marilene, Poh, Chueh Loo, Pretorius, Isak S., Rosser, Susan J., Scrutton, Nigel S., Storch, Marko, Tekotte, Hille, Travnik, Evelyn, Vickers, Claudia E., Yew, Wen Shan, Yuan, Yingjin, Zhao, Huimin, and Freemont, Paul S.

Abstract

Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.

Published
2019

8. A Combinatorial Approach To Study Cytochrome P450 Enzymes for De Novo Production of Steviol Glucosides in Baker’s Yeast

Author

Gold, Nicholas D., Fossati, Elena, Hansen, Cecilie Ida Cetti, DiFalco, Marcos, Douchin, Veronique, Martin, Vincent J.J., Gold, Nicholas D., Fossati, Elena, Hansen, Cecilie Ida Cetti, DiFalco, Marcos, Douchin, Veronique, and Martin, Vincent J.J.

Abstract

Biosynthesis of steviol glycosides in planta proceeds via two cytochrome P450 enzymes (CYPs): kaurene oxidase (KO) and kaurenoic acid hydroxylase (KAH). KO and KAH function in succession with the support of a NADPH-dependent cytochrome P450 reductase (CPR) to convert kaurene to steviol. This work describes a platform for recombinant production of steviol glucosides (SGs) in Saccharomyces cerevisiae, demonstrating the full reconstituted pathway from the simple sugar glucose to the SG precursor steviol. With a focus on optimization of the KO-KAH activities, combinations of functional homologues were tested in batch growth. Among the CYPs, novel KO75 (CYP701) and novel KAH82 (CYP72) outperformed their respective functional homologues from Stevia rebaudiana, SrKO (CYP701A5) and SrKAH (CYP81), in assays where substrate was supplemented to culture broth. With kaurene produced from glucose in the cell, SrCPR1 from S. rebaudiana supported highest turnover for KO-KAH combinations, besting two other CPRs isolated from S. rebaudiana, the Arabidopsis thaliana ATR2, and a new class I CPR12. Some coexpressions of ATR2 with a second CPR were found to diminish KAH activity, showing that coexpression of CPRs can lead to competition for CYPs with possibly adverse effects on catalysis.

Published
2018

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