1. IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes
- Author
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Falkencrone, Sidsel, Poulsen, Lars K., Bindslev-Jensen, Carsten, Andersen, Anders Woetmann, Ødum, Niels, Poulsen, Britta Cathrina, Blom, L., Jensen, B. M., Gibbs, B. F., Yasinska, I. M., Sumbayev, V. V., Skov, P. S., Falkencrone, Sidsel, Poulsen, Lars K., Bindslev-Jensen, Carsten, Andersen, Anders Woetmann, Ødum, Niels, Poulsen, Britta Cathrina, Blom, L., Jensen, B. M., Gibbs, B. F., Yasinska, I. M., Sumbayev, V. V., and Skov, P. S.
- Abstract
IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
- Published
- 2013