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Your search keyword '"Gerber, David E."' showing total 5 results
Start Over Author "Gerber, David E." Publication Type Electronic Resources
5 results on '"Gerber, David E."'

1. TTFields (Tumor Treating Fields) associés au traitement standard dans les cancers du poumon non à petites cellules métastatiques en progression après sels de platine :Étude internationale, randomisée de phase 3 LUNAR

Author

Berghmans, Thierry, Leal, Teresinha, KOTECHA, RUPESH, Ramlau, Rodryg, Zhang, L, Milanowski, Janusz, Cobo, Manuel, Roubec, Jaromir, Petruzelka, L, Havel, Libor, Kalmadi, Jujith, Ward, James, Andric, Zoran, Gerber, David, E, Kloecker, Goetz, Panikkar, Rajiv, Aerts, J., Delmonte, Angelo, Pless, Miklos, Langer, C., Berghmans, Thierry, Leal, Teresinha, KOTECHA, RUPESH, Ramlau, Rodryg, Zhang, L, Milanowski, Janusz, Cobo, Manuel, Roubec, Jaromir, Petruzelka, L, Havel, Libor, Kalmadi, Jujith, Ward, James, Andric, Zoran, Gerber, David, E, Kloecker, Goetz, Panikkar, Rajiv, Aerts, J., Delmonte, Angelo, Pless, Miklos, and Langer, C.

Abstract

info:eu-repo/semantics/published

Published
2024

2. Tumor Treating Fields therapy with standard systemic therapy versus standard systemic therapy alone in metastatic non-small-cell lung cancer following progression on or after platinum-based therapy (LUNAR): a randomised, open-label, pivotal phase 3 study

Author

Leal, Ticiana, KOTECHA, RUPESH, Ramlau, Rodryg, Milanowski, Janusz, Cobo, Manuel, Roubec, Jaromir, Petruzelka, L, Havel, Libor, Kalmadi, Jujith, Ward, Jeffrey, Andric, Zoran, Berghmans, Thierry, Gerber, David, E, Kloecker, Goetz, Panikkar, Rajiv, Aerts, Joachim J.G.J.V., Delmonte, Angelo, Pless, Miklos, Greil, Richard, Rolfo, Christian, A Beccara, Wallace, Eaton, Michael, Iqbal, Mussawar, Langer, Corey, Leal, Ticiana, KOTECHA, RUPESH, Ramlau, Rodryg, Milanowski, Janusz, Cobo, Manuel, Roubec, Jaromir, Petruzelka, L, Havel, Libor, Kalmadi, Jujith, Ward, Jeffrey, Andric, Zoran, Berghmans, Thierry, Gerber, David, E, Kloecker, Goetz, Panikkar, Rajiv, Aerts, Joachim J.G.J.V., Delmonte, Angelo, Pless, Miklos, Greil, Richard, Rolfo, Christian, A Beccara, Wallace, Eaton, Michael, Iqbal, Mussawar, and Langer, Corey

Abstract

Tumor Treating Fields (TTFields) are electric fields that disrupt processes critical for cancer cell survival, info:eu-repo/semantics/inPress

Published
2023

3. Treatment Design and Rationale for a Randomized Trial of Cisplatin and Etoposide Plus Thoracic Radiotherapy Followed by Nivolumab or Placebo for Locally Advanced Non-Small-Cell Lung Cancer (RTOG 3505).

Author

Gerber, David E, Gerber, David E, Urbanic, James J, Langer, Corey, Hu, Chen, Chang, I-Fen, Lu, Bo, Movsas, Benjamin, Jeraj, Robert, Curran, Walter J, Bradley, Jeffrey D, Gerber, David E, Gerber, David E, Urbanic, James J, Langer, Corey, Hu, Chen, Chang, I-Fen, Lu, Bo, Movsas, Benjamin, Jeraj, Robert, Curran, Walter J, and Bradley, Jeffrey D

Abstract

Radiation Therapy Oncology Group (RTOG) 3505 is a randomized phase 3 study of concurrent chemoradiation followed by immune checkpoint inhibitor therapy or placebo in patients with locally advanced non-small-cell lung cancer (NSCLC). Patients with surgically unresectable stage 3 NSCLC will receive thoracic radiotherapy to 60 Gy with concurrent cisplatin 50 mg/m2 intravenously (I.V.) on days 1, 8, 29, and 36, and etoposide 50 mg/m2 I.V. on days 1 to 5 and days 29 to 33. Between 4 and 12 weeks after completion of concurrent chemoradiation, eligible patients will be randomized to the anti-programmed death 1 (PD-1) monoclonal antibody nivolumab 240 mg I.V. or placebo every 2 weeks for up to 1 year. The primary end points are overall survival (OS) and progression-free survival (PFS), as determined by central independent radiology review. Secondary objectives include toxicity assessment, patient-reported outcomes and quality of life, and OS and PFS in programmed death ligand 1 (PD-L1) expressors (≥ 1%) and PD-L1 nonexpressors (< 1%). Assuming a rate of 16.7% due to ineligibility and dropout before randomization, a total of 660 patients will be enrolled to ensure 550 patients will be randomized after completion of chemoradiation. This sample size will provide ≥ 90% power to detect a hazard ratio of 0.7 for OS with 2-sided type I error of 0.04, and to detect a hazard ratio of 0.667 for PFS 2-sided type I error of 0.01. (NCT02768558).

Published
2017

4. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Author

Bunn, Paul A., Jr., Minna, John D., Augustyn, Alexander, Gazdar, Adi F., Ouadah, Youcef, Krasnow, Mark A., Berns, Anton, Brambilla, Elisabeth, Rekhtman, Natasha, Massion, Pierre P., Niederst, Matthew, Peifer, Martin, Yokota, Jun, Govindan, Ramaswamy, Poirier, John T., Byers, Lauren A., Wynes, Murry W., McFadden, David G., MacPherson, David, Hann, Christine L., Farago, Anna F., Dive, Caroline, Teicher, Beverly A., Peacock, Craig D., Johnson, Jane E., Cobb, Melanie H., Wendel, Hans -Guido, Spigel, David, Sage, Julien, Yang, Ping, Pietanza, M. Catherine, Krug, Lee M., Heymach, John, Ujhazy, Peter, Zhou, Caicun, Goto, Koichi, Dowlati, Afshin, Christensen, Camilla Laulund, Park, Keunchil, Einhorn, Lawrence H., Edelman, Martin J., Giaccone, Giuseppe, Gerber, David E., Salgia, Ravi, Owonikoko, Taofeek, Malik, Shakun, Karachaliou, Niki, Gandara, David R., Slotman, Ben J., Blackhall, Fiona, Goss, Glenwood, Thomas, Roman, Rudin, Charles M., Hirsch, Fred R., Bunn, Paul A., Jr., Minna, John D., Augustyn, Alexander, Gazdar, Adi F., Ouadah, Youcef, Krasnow, Mark A., Berns, Anton, Brambilla, Elisabeth, Rekhtman, Natasha, Massion, Pierre P., Niederst, Matthew, Peifer, Martin, Yokota, Jun, Govindan, Ramaswamy, Poirier, John T., Byers, Lauren A., Wynes, Murry W., McFadden, David G., MacPherson, David, Hann, Christine L., Farago, Anna F., Dive, Caroline, Teicher, Beverly A., Peacock, Craig D., Johnson, Jane E., Cobb, Melanie H., Wendel, Hans -Guido, Spigel, David, Sage, Julien, Yang, Ping, Pietanza, M. Catherine, Krug, Lee M., Heymach, John, Ujhazy, Peter, Zhou, Caicun, Goto, Koichi, Dowlati, Afshin, Christensen, Camilla Laulund, Park, Keunchil, Einhorn, Lawrence H., Edelman, Martin J., Giaccone, Giuseppe, Gerber, David E., Salgia, Ravi, Owonikoko, Taofeek, Malik, Shakun, Karachaliou, Niki, Gandara, David R., Slotman, Ben J., Blackhall, Fiona, Goss, Glenwood, Thomas, Roman, Rudin, Charles M., and Hirsch, Fred R.

Published
2016

5. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Author

Bunn, Paul A., Jr., Minna, John D., Augustyn, Alexander, Gazdar, Adi F., Ouadah, Youcef, Krasnow, Mark A., Berns, Anton, Brambilla, Elisabeth, Rekhtman, Natasha, Massion, Pierre P., Niederst, Matthew, Peifer, Martin, Yokota, Jun, Govindan, Ramaswamy, Poirier, John T., Byers, Lauren A., Wynes, Murry W., McFadden, David G., MacPherson, David, Hann, Christine L., Farago, Anna F., Dive, Caroline, Teicher, Beverly A., Peacock, Craig D., Johnson, Jane E., Cobb, Melanie H., Wendel, Hans -Guido, Spigel, David, Sage, Julien, Yang, Ping, Pietanza, M. Catherine, Krug, Lee M., Heymach, John, Ujhazy, Peter, Zhou, Caicun, Goto, Koichi, Dowlati, Afshin, Christensen, Camilla Laulund, Park, Keunchil, Einhorn, Lawrence H., Edelman, Martin J., Giaccone, Giuseppe, Gerber, David E., Salgia, Ravi, Owonikoko, Taofeek, Malik, Shakun, Karachaliou, Niki, Gandara, David R., Slotman, Ben J., Blackhall, Fiona, Goss, Glenwood, Thomas, Roman, Rudin, Charles M., Hirsch, Fred R., Bunn, Paul A., Jr., Minna, John D., Augustyn, Alexander, Gazdar, Adi F., Ouadah, Youcef, Krasnow, Mark A., Berns, Anton, Brambilla, Elisabeth, Rekhtman, Natasha, Massion, Pierre P., Niederst, Matthew, Peifer, Martin, Yokota, Jun, Govindan, Ramaswamy, Poirier, John T., Byers, Lauren A., Wynes, Murry W., McFadden, David G., MacPherson, David, Hann, Christine L., Farago, Anna F., Dive, Caroline, Teicher, Beverly A., Peacock, Craig D., Johnson, Jane E., Cobb, Melanie H., Wendel, Hans -Guido, Spigel, David, Sage, Julien, Yang, Ping, Pietanza, M. Catherine, Krug, Lee M., Heymach, John, Ujhazy, Peter, Zhou, Caicun, Goto, Koichi, Dowlati, Afshin, Christensen, Camilla Laulund, Park, Keunchil, Einhorn, Lawrence H., Edelman, Martin J., Giaccone, Giuseppe, Gerber, David E., Salgia, Ravi, Owonikoko, Taofeek, Malik, Shakun, Karachaliou, Niki, Gandara, David R., Slotman, Ben J., Blackhall, Fiona, Goss, Glenwood, Thomas, Roman, Rudin, Charles M., and Hirsch, Fred R.

Published
2016

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