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Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.

Realizabilty is a branch of logic that aims at extracting the computational content of mathematical proofs by establishing a correspondence between proofs and programs. Invented by S.C. Kleene in the 1945 to develop a connection between intuitionism and Turing computable functions, realizability has evolved to include not only classical logic but even set theory, thanks to the work of J-L. Krivine. Krivine’s work made possible to build realizability models for Zermelo-Frænkel set theory, ZF, assuming its consistency. Nevertheless, a large part of set theoretic research involves investigating further axioms that are known as large cardinals axioms; in this paper we focus on four large cardinals axioms: the axioms of (strongly) inaccessible cardinal, Mahlo cardinals, measurable cardinals and Reinhardt cardinals. We show how to build realizability models for each of these four axioms assuming their consistency relative to ZFC or ZF.

We propose a linear algebraic method, rooted in the spectral properties of graphs, that can be used to prove lower bounds in communication complexity. Our proof technique effectively marries spectral bounds with information-theoretic inequalities. The key insight is the observation that, in specific settings, even when data sets X and Y are closely correlated and have high mutual information, the owner of X cannot convey a reasonably short message that maintains substantial mutual information with Y. In essence, from the perspective of the owner of Y, any sufficiently brief message m = m(X) would appear nearly indistinguishable from a random bit sequence. We employ this argument in several problems of communication complexity. Our main result concerns cryptographic protocols. We establish a lower bound for communication complexity of multi-party secret key agreement with unconditional, i.e., information-theoretic security. Specifically, for one-round protocols (simultaneous messages model) of secret key agreement with three participants we obtain an asymptotically tight lower bound. This bound implies optimality of the previously known omniscience communication protocol (this result applies to a non-interactive secret key agreement with three parties and input data sets with an arbitrary symmetric information profile). We consider communication problems in one-shot scenarios when the parties inputs are not produced by any i.i.d. sources, and there are no ergodicity assumptions on the input data. In this setting, we found it natural to present our results using the framework of Kolmogorov complexity.

Tidal currents flowing over rough bathymetry generate internal tides. These internal waves with tidal frequency can be decomposed into vertical modes. Low modes generally travel thousands of kilometers, until they break due to shear flow instabilities, while high modes are believed to break close to the generation site. The power released by breaking internal tides is thought not only to shape the overturning circulation, but also to mix the upper ocean. Both processes have a large influence on the climate system, most notably for their key role in regulating the heat and carbon uptake by the ocean. The generation of internal tides, or tidal conversion, can be calculated from the bottom topography, the ocean stratification and the tidal currents. Global computations of the tidal conversion have been based on linear wave theory. However, such linear calculations are only valid if the seafloor slope is subcritical, and it is not known how to treat supercritical slopes. This is especially true for the conversion decomposed into vertical modes, which, taken individually, behaves very differently from the total conversion (the sum of the contributions from all modes). In the first paper of this thesis, we looked into the validity of linear theory in the supercritical limit. Specifically, we translated the critical slope condition, a notion defined for the superposition of all modes, into a mode-wise condition on the topographic height. The findings were applied to estimates of the global M2-tide conversion into the first 10 vertical modes (in the open ocean, excluding the continental shelves and slopes). The results unveil the rapid increase with mode number of the oceanic area where linear theory fails. In terms of conversion, this shows that linear theory is unadapted to quantify the role played by high modes in closing the internal wave energy budget. Typically, continental slopes are supercritical, and hence locations where the linear theory fails. Because of their c

Point defects in two-dimensional materials are of key interest for quantum information science. However, the parameter space of possible defects is immense, making the identification of high-performance quantum defects very challenging. Here, we perform high-throughput (HT) first-principles computational screening to search for promising quantum defects within WS2, which present localized levels in the band gap that can lead to bright optical transitions in the visible or telecom regime. Our computed database spans more than 700 charged defects formed through substitution on the tungsten or sulfur site. We found that sulfur substitutions enable the most promising quantum defects. We computationally identify the neutral cobalt substitution to sulfur (Co S0 ) and fabricate it with scanning tunneling microscopy (STM). The Co S0 electronic structure measured by STM agrees with first principles and showcases an attractive quantum defect. Our work shows how HT computational screening and nanoscale synthesis routes can be combined to design promising quantum defects.

Debate remains around the anatomical origins of specific brain cell subtypes and lineage relationships within the human forebrain1-7. Thus, direct observation in the mature human brain is critical for a complete understanding of its structural organization and cellular origins. Here we utilize brain mosaic variation within specific cell types as distinct indicators for clonal dynamics, denoted as cell-type-specific mosaic variant barcode analysis. From four hemispheres and two different human neurotypical donors, we identified 287 and 780 mosaic variants, respectively, that were used to deconvolve clonal dynamics. Clonal spread and allele fractions within the brain reveal that local hippocampal excitatory neurons are more lineage-restricted than resident neocortical excitatory neurons or resident basal ganglia GABAergic inhibitory neurons. Furthermore, simultaneous genome transcriptome analysis at both a cell-type-specific and a single-cell level suggests a dorsal neocortical origin for a subgroup of DLX1+ inhibitory neurons that disperse radially from an origin shared with excitatory neurons. Finally, the distribution of mosaic variants across 17 locations within one parietal lobe reveals that restriction of clonal spread in the anterior-posterior axis precedes restriction in the dorsal-ventral axis for both excitatory and inhibitory neurons. Thus, cell-type-resolved somatic mosaicism can uncover lineage relationships governing the development of the human forebrain.

Este proyecto de innovación docente se propone crear una comunidad colaborativa, que incluya profesores/as del Máster en Estudios LGBTIQ+ y del Departamento de Historia, Teorías y Geografías Políticas, a estudiantes de grado y posgrado y docentes de Europa y América Latina, para la producción y postproducción de podcasts que se enfoquen con una innovadora perspectiva pluridisciplinar en el análisis crítico de los procesos históricos, políticos y socioculturales de construcción de las diversidades sexogenéricas y contribuyan a la divulgación de las investigaciones que dan visibilidad a toda diversidad. Además, los podcasts propuestos tienen un planteamiento interseccional, es decir promueven un enfoque que subraye la compleja interrelación entre sexo, género, etnia, clase y orientación sexual. Nuestro proyecto pone en relación el PDI de cinco facultades UCM (Facultad de Geografía e Historia – Giulia Quaggio; Facultad de Filología – Arno Gimber y Evangelina Soltero Sánchez; Facultad de Psicología – Marta Evelia Aparicio García; Facultad de Ciencias Políticas y Sociología – José Luis Ledesma Vera y Facultad de Bellas Artes – Laura de la Colina Tejada), haciéndose eco del pionero carácter humanista multidisciplinar del Máster en Estudios LGBTIQ+. Se trata de un PID que pone en relación un rico abanico de recursos humanos, creando un laboratorio formativo no solo entre distintas facultades de ciencias sociales y humanidades UCM, sino también entre distintos países del mundo y diferentes etapas de la carrera académica y formativa, contribuyendo así a la circulación de ideas, metodologías y contactos.

Optically active quantum defects play an important role in quantum sensing, computing and communication. The electronic structure and the single-particle energy levels of these quantum defects in the semiconducting host have been used to understand their optoelectronic properties. Optical excitations that are central for their initialization and readout are linked to transitions between occupied and unoccupied single-particle states. It is commonly assumed that only quantum defects introducing levels well within the band gap and far from the band edges are of interest for quantum technologies as they mimic an isolated atom embedded in the host. In this perspective, we contradict this common assumption and show that optically active defects with energy levels close to the band edges can display similar properties. We highlight quantum defects that are excited through transitions to or from a band-like level (bound exciton) such as the T center and Se S i + in silicon. We also present how defects such as the silicon split-vacancy in diamond can involve transitions between localized levels that are above the conduction band or below the valence band. Loosening the commonly assumed requirement on the electronic structure of quantum defects offers opportunities in quantum defects design and discovery especially in smaller band gap hosts such as silicon. We discuss the challenges in terms of operating temperature for photoluminescence or radiative lifetime in this regime. We also highlight how these alternative type of defects bring their own needs in terms of theoretical developments and fundamental understanding. This perspective clarifies the electronic structure requirement for quantum defects and will facilitate the identification and design of new color centers for quantum applications especially driven by first principles computations.

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Silicon is the ideal material for building electronic and photonic circuits at scale. Integrated photonic quantum technologies in silicon offer a promising path to scaling by leveraging advanced semiconductor manufacturing and integration capabilities. However, the lack of deterministic quantum light sources and strong photon-photon interactions in silicon poses a challenge to scalability. In this work, we demonstrate an indistinguishable photon source in silicon photonics based on an artificial atom. We show that a G center in a silicon waveguide can generate high-purity telecom-band single photons. We perform high-resolution spectroscopy and time-delayed two-photon interference to demonstrate the indistinguishability of single photons emitted from a G center in a silicon waveguide. Our results show that artificial atoms in silicon photonics can source single photons suitable for photonic quantum networks and processors.

Thin-film materials with large electromechanical responses are fundamental enablers of next-generation micro-/nano-electromechanical applications. Conventional electromechanical materials (for example, ferroelectrics and relaxors), however, exhibit severely degraded responses when scaled down to submicrometre-thick films due to substrate constraints (clamping). This limitation is overcome, and substantial electromechanical responses in antiferroelectric thin films are achieved through an unconventional coupling of the field-induced antiferroelectric-to-ferroelectric phase transition and the substrate constraints. A detilting of the oxygen octahedra and lattice-volume expansion in all dimensions are observed commensurate with the phase transition using operando electron microscopy, such that the in-plane clamping further enhances the out-of-plane expansion, as rationalized using first-principles calculations. In turn, a non-traditional thickness scaling is realized wherein an electromechanical strain (1.7%) is produced from a model antiferroelectric PbZrO3 film that is just 100 nm thick. The high performance and understanding of the mechanism provide a promising pathway to develop high-performance micro-/nano-electromechanical systems.

Background and study aim: Computer-aided detection (CADe) has been developed to improve detection during colonoscopy. After initial reports of high efficacy, there has been an increasing recognition of variability in the effectiveness of CADe systems. The aim of this study was to evaluate a CADe system (PENTAX Medical, Tokyo, Japan) in a varied colonoscopy population. Patients and methods: A multicenter, randomized trial was conducted at 7 hospitals (both university and non-university) in Europe and Canada. Participants referred for diagnostic, non-iFOBT screening, or surveillance colonoscopy were randomized (1:1) to undergo CADe-assisted or conventional colonoscopy (CC) by experienced endoscopists. Participants with insufficient bowel preparation were excluded from the analysis. Primary outcome was adenoma detection rate (ADR). Secondary outcomes included adenomas per colonoscopy (APC) and sessile serrated lesions per colonoscopy (SSLPC). Results: In total, 581 participants were enrolled, of which 497 were included in the final analysis: 250 in the CADe-arm and 247 in the CC-arm. Surveillance was the indication in 202/497 (40.6%) colonoscopies, diagnostic in 199/497 (40.0%), and non-iFOBT screening in 96/497 (19.3%). Overall, ADR (38.4% vs. 37.7%; p=0.43) and APC (0.66 vs. 0.66; p=0.97) were similar between CADe and CC. SSLPC was increased (0.30 vs. 0.19; p=0.049) in the CADe-arm vs. CC. Conclusions: In this study conducted by experienced endoscopists, CADe did not result in a statistically significant increase in ADR. However, the ADR of our control group substantially surpassed our sample size assumptions, increasing the risk of an underpowered trial. (Trialsearch.who.int:NL9135).

Background: Trigonocephaly occurs due to the premature fusion of the metopic suture, leading to a triangular forehead and hypotelorism. This condition often requires surgical correction for morphological and functional indications. Metopic ridges also originate from premature metopic closure but are only associated with mid-frontal bulging; their surgical correction is rarely required. Differential diagnosis between these two conditions can be challenging, especially in minor trigonocephaly. Methods: Two hundred seven scans of patients with trigonocephaly (90), metopic rigdes (27), and controls (90) were collected. Geometric morphometrics were used to quantify skull and orbital morphology as well as the interfrontal angle and the cephalic index. An innovative method was developed to automatically compute the frontal curvature along the metopic suture. Different machine-learning algorithms were tested to assess the predictive power of morphological data in terms of classification. Results: We showed that control patients, trigonocephaly and metopic rigdes have distinctive skull and orbital shapes. The 3D frontal curvature enabled a clear discrimination between groups (sensitivity and specificity > 92%). Furthermore, we reached an accuracy of 100% in group discrimination when combining 6 univariate measures. Conclusion: Two diagnostic tools were proposed and demonstrated to be successful in assisting differential diagnosis for patients with trigonocephaly or metopic ridges. Further clinical assessments are required to validate the practical clinical relevance of these tools.

The International Ocean Discovery Program (IODP) Expedition 396 to the mid-Norwegian margin recovered > 1300 m of pristinely preserved, volcanic-ash-rich sediments deposited during the late Paleocene and early Eocene from close to the centre of the North Atlantic Igneous Province (NAIP). Remarkably, many of these cores contain glendonites, pseudomorphs after the purported cold-water mineral ikaite, from sediments dated to the late Paleocene and early Eocene. These time intervals span some of the hottest climates of the Cenozoic, including the Paleocene–Eocene Thermal Maximum (PETM). Global deep-ocean temperatures are not thought to have dropped below 10 ∘C at any point during this time, making the occurrence of supposedly cold-water (near-freezing temperature) glendonite pseudomorphs seemingly paradoxical. This study presents a detailed sedimentological, geochemical, and microscopic study of the IODP Exp. 396 glendonites and presents an updated model for the ikaite-to-calcite transformation for these glendonites. Specifically, we show that early diagenesis of basaltic ashes of the NAIP appear to have chemically promoted ikaite growth in the sediments in this region. Together with existing knowledge of late Paleocene and early Eocene glendonites from Svalbard to the north and early Eocene glendonites from Denmark to the south, these new glendonite finds possibly imply episodic, short-duration, and likely localized cooling in the Nordic Seas region, which may have been directly or indirectly linked to the emplacement of the NAIP.

While basaltic volcanism is dominate during rifting and continental breakup, felsic magmatism may also comprise important components of some rift margins. During International Ocean Discovery Program (IODP) Expedition 396 on the continental margin of Norway, a graphite-garnet-cordierite bearing dacitic, pyroclastic unit was recovered within early Eocene sediments on Mimir High (Site U1570), a marginal high on the Vøring transform margin. Here, we present a comprehensive textural, mineralogical, and petrological study of the dacite in order to assess its melting origin and emplacement. The major mineral phases (garnet, cordierite, quartz, plagioclase, alkali feldspar) are hosted in a fresh rhyolitic, highly vesicular, glassy matrix, locally mingled with sediments. The xenocrystic major element chemistry of garnet and cordierite, the presence of zircon inclusions with inherited cores, and thermobarometric calculations all support a crustal metapelite origin. While most magma-rich margin models favor crustal anatexis in the lower crust, thermobarometric calculations performed here show that the dacite was produced at upper-crustal depths (< 5 kbar) and high temperature (750–800 °C) with up to 3 wt% water content. In situ U-Pb analyses on zircon inclusions give a magmatic age of 54.6 ± 1.1 Ma, revealing the emplacement of the dacite post-dates the Paleocene-Eocene Thermal Maximum (PETM). Our results suggest that the opening of the North Atlantic was associated with a phase of low-pressure, high-temperature crustal melting at the onset of the main phase of magmatism.

Three boreholes drilled during the International Ocean Discovery Program (IODP) Expedition 396 have yielded unexpected findings of altered granitic rocks covered by basalt flows, interbedded sediments and glacial mud near the continent‐ocean transition of the mid‐Norwegian margin. U‐Pb and K‐Ar geochronological analyses were conducted on both protolithic and authigenically formed K‐bearing minerals to determine the age of granite crystallisation and subsequent alteration episodes. The granite's crystallisation age based on 104 zircons is 56.3 ± 0.2 Ma, and subsequent exhumation along with alteration/weathering events took place between 54.7 ± 1 and 37.1 ± 1 Ma. This intrusion represents the youngest granite discovered in Norway and intruded at an extremely shallow crustal level before a rapid rift‐to‐drift transition. The shallow emplacement of granitic rock and its fast exhumation before and during the onset of volcanism holds significant implications for the syn‐ and post‐breakup tectonic evolution of volcanic margins.

Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with FAS mutations (ALPS-FAS), but paradoxically, fewer conventional memory cells differentiate from FAS-expressing germinal center (GC) B cells. Resistance to FAS-induced apoptosis does not explain this phenotype. We tested the hypothesis that defective non-apoptotic FAS signaling may contribute to impaired B cell differentiation in ALPS. We analyzed secondary lymphoid organs of patients with ALPS-FAS and found low numbers of memory B cells, fewer GC B cells, and an expanded extrafollicular (EF) B cell response. Enhanced mTOR activity has been shown to favor EF versus GC fate decision, and we found enhanced PI3K/mTOR and BCR signaling in ALPS-FAS splenic B cells. Modeling initial T-dependent B cell activation with CD40L in vitro, we showed that FAS competent cells with transient FAS ligation showed specifically decreased mTOR axis activation without apoptosis. Mechanistically, transient FAS engagement with involvement of caspase-8 induced nuclear exclusion of PTEN, leading to mTOR inhibition. In addition, FASL-dependent PTEN nuclear exclusion and mTOR modulation were defective in patients with ALPS-FAS. In the early phase of activation, FAS stimulation promoted expression of genes related to GC initiation at the expense of processes related to the EF response. Hence, our data suggest that non-apoptotic FAS signaling acts as molecular switch between EF versus GC fate decisions via regulation of the mTOR axis and transcription. The defect of this modulatory circuit may explain the observed hypergammaglobulinemia and low memory B cell numbers in ALPS.

Gut–brain communications disorders in irritable bowel syndrome (IBS) are associated with intestinal microbiota composition, increased gut permeability, and psychosocial disturbances. Symptoms of IBS are difficult to medicate, and hence much research is being made into alternative approaches. This study assesses the potential of a treatment with pasteurized Akkermansia muciniphila for alleviating IBS-like symptoms in two mouse models of IBS with different etiologies. Two clinically relevant animal models were used to mimic IBS-like symptoms in C57BL6/J mice: the neonatal maternal separation (NMS) paradigm and the Citrobacter rodentium infection model. In both models, gut permeability, colonic sensitivity, fecal microbiota composition and colonic IL-22 expression were evaluated. The cognitive performance and emotional state of the animals were also assessed by several tests in the C. rodentium infection model. The neuromodulation ability of pasteurized A. muciniphila was assessed on primary neuronal cells from mice dorsal root ganglia using a ratiometric calcium imaging approach. The administration of pasteurized A. muciniphila significantly reduced colonic hypersensitivity in both IBS mouse models, accompanied by a reinforcement of the intestinal barrier function. Beneficial effects of pasteurized A. muciniphila treatment have also been observed on anxiety-like behavior and memory defects in the C. rodentium infection model. Finally, a neuroinhibitory effect exerted by pasteurized A. muciniphila was observed on neuronal cells stimulated with two algogenic substances such as capsaicin and inflammatory soup. Our findings demonstrate novel anti-hyperalgesic and neuroinhibitory properties of pasteurized A. muciniphila, which therefore may have beneficial effects in relieving pain and anxiety in subjects with IBS.

Given the important role turbulence plays in the settling and growth of dust grains in protoplanetary disks, it is crucial that we determine whether these disks are turbulent and to what extent. Protoplanetary disks are weakly ionized near the mid-plane, which has led to a paradigm in which largely laminar magnetic field structures prevail deeper in the disk, with angular momentum being transported via magnetically launched winds. Yet, there has been little exploration on the precise behavior of the gas within the bulk of the disk. We carry out 3D, local shearing box simulations that include all three low-ionization effects (Ohmic diffusion, ambipolar diffusion, and the Hall effect) to probe the nature of magnetically driven gas dynamics 1-30 AU from the central star. We find that gas turbulence can persist with a generous yet physically motivated ionization prescription (order unity Elsasser numbers). The gas velocity fluctuations range from 0.03-0.09 of the sound speed $c_s$ at the disk mid-plane to $\sim c_s$ near the disk surface, and are dependent on the initial magnetic field strength. However, the turbulent velocities do not appear to be strongly dependent on the field polarity, and thus appear to be insensitive to the Hall effect. The mid-plane turbulence has the potential to drive dust grains to collision velocities exceeding their fragmentation limit, and likely reduces the efficacy of particle clumping in the mid-plane, though it remains to be seen if this level of turbulence persists in disks with lower ionization levels., Comment: 23 pages, 19 figures, 2 tables, submitted to ApJ

This chapter provides an illustrated discussion of seven methodological considerations for researchers setting up a critical discourse study (CDS) of media and information literacy (MIL) projects. These considerations relate to the construction of a CDS-informed problematic (how to choose an appropriate CDS approach; how to identify relevant discourses), as well as to matters of data collection (how to select cases; how to draw boundaries around discourses) and data analysis (how to choose relevant units of analysis; why coding might be useful; how to analyze the political and ideological dimensions of discourse). This chapter illustrates the implications of decisions concerning each consideration with reference to a study of the MIL project of the European Association for Viewers Interests (EAVI). In doing so, the authors do not seek to (de)legitimize EAVI’s project but to demonstrate how CDS allows researchers to render the political and ideological dimensions of MIL discourses explicit, enabling democratic debates about the discourses that shape our world., info:eu-repo/semantics/published

This chapter provides an illustrated discussion of seven methodological considerations for researchers setting up a critical discourse study (CDS) of media and information literacy (MIL) projects. These considerations relate to the construction of a CDS-informed problematic (how to choose an appropriate CDS approach; how to identify relevant discourses), as well as to matters of data collection (how to select cases; how to draw boundaries around discourses) and data analysis (how to choose relevant units of analysis; why coding might be useful; how to analyze the political and ideological dimensions of discourse). This chapter illustrates the implications of decisions concerning each consideration with reference to a study of the MIL project of the European Association for Viewers Interests (EAVI). In doing so, the authors do not seek to (de)legitimize EAVI’s project but to demonstrate how CDS allows researchers to render the political and ideological dimensions of MIL discourses explicit, enabling democratic debates about the discourses that shape our world., This presentation is based on the following publication: https://www.taylorfrancis.com/chapters/edit/10.4324/9781003045366-18/critical-discourse-studies-research-media-information-literacy-projects-jan-zienkowski-geoffroy-patriarche?context=ubx&refId=e4f3d215-3bbd-49d4-a494-b2fa9b539507, info:eu-repo/semantics/nonPublished

Protein-based biopharmaceuticals require high purity before final formulation to ensure product safety, making process development time consuming. Implementation of computational approaches at the initial stages of process development offers a significant reduction in development efforts. By preselecting process conditions, experimental screening can be limited to only a subset. One such computational selection approach is the application of Quantitative Structure Property Relationship (QSPR) models that describe the properties exploited during purification. This work presents a novel open-source Python tool capable of extracting a range of features from protein 3D models on a local computer allowing total transparency of the calculations. As open-source tool, it also impacts initial investments in constructing a QSPR workflow for protein property prediction for third parties, making it widely applicable within the field of bioprocess development. The focus of current calculated molecular features is projection onto the protein surface by constructing surface grid representations. Linear regression models were trained with the calculated features to predict chromatographic retention times/volumes. Model validation shows a high accuracy for anion and cation exchange chromatography data (cross-validated R2 of 0.87 and 0.95). Hence, these models demonstrate the potential of the use of QSPR to accelerate process design., BT/Bioprocess Engineering, BT/Design and Engineering Education

This dossier offers a critical reflection on the shame/pride dichotomy as an articulating axis of the LGBT world before and after the liberation movements of the 1970s. In the set of articles, the aim is to demonstrate that this dichotomy is in fact reductive since both everyday experiences and literary, audiovisual and film productions produced in Spain and Latin America throughout the twentieth and twenty-first centu-ries show that pride and shame are tensioned in a complex way: neither pride triumphs in an absolute way from the “liberation”, nor shame is the paradigmatic experience of the previous period. The articles explore, in very diverse discourses –novels, newspa-pers, poetry, visual arts, documentaries, theatrical productions– how pride and shame constituted the subjectivities –and artistic manifestations– of dissident creators both in contexts that were mostly hostile to sex-gender diversity and in others that were progressively more tolerant., Este dossier propõe uma reflexão crítica sobre a dicotomia vergonha/orgulho como eixo articulador do universo LGBT antes e depois dos movimentos libertários da década de 1970. Tem por objetivo demostrar que esta dicotomia é redutora, uma vez que tanto as experiências quotidianas como as produções literárias, audiovisuais e cinematográficas produzidas em Espanha e na América Latina ao longo dos séculos XX e XXI demonstram que o orgulho e a vergonha estão em tensão complexa: nem o orgulho triunfa absolutamente após a “libertação”, nem a vergonha é a experiência paradigmática do período anterior. Os artigos exploram, em discursos muito diversos –romances, jornais, poesia, artes plásticas, documentários, peças de teatro– a forma como o orgulho e a vergonha constituíram as subjectividades –e as manifestações artís-ticas– de criadores dissidentes, tanto em contextos largamente hostis à diversidade de género como noutros progressivamente mais tolerantes, Este dossier propone una reflexión crítica acerca de la dicotomía vergüenza/orgullo como eje articulador del universo LGTB antes y después de los movimientos de liberación de los 70. En el conjunto de artículos, se pretende demostrar que esa dicotomía es, en realidad, reductora, pues tanto las vivencias cotidianas como las producciones literarias, audiovisuales y cinematográficas producidas en España y Latinoamérica a lo largo de los siglos XX y XXI demuestran que el orgullo y la vergüenza se tensionan de manera compleja: ni el orgullo triunfa de manera absoluta a partir de la “liberación” de la década de 1970, ni la vergüenza es la experiencia paradigmática del periodo previo. Los artículos exploran, en discursos muy diversos –novelas, diarios, poesía, artes plásticas, documentales, puestas teatrales– cómo el orgullo y la vergüenza constituyeron las subjetividades –y las manifestaciones artísticas– de creadores disidentes tanto en contextos mayormente hostiles a la diversidad sexogenérica, como en otros progresivamente más tolerantes.

Contains fulltext : 298566.pdf (Publisher’s version ) (Closed access), Objectives: To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors. Methods: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables. Results: Among 2,385 participants, mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56). Conclusion: Physical function is impaired for many individuals with SSc and associated with multiple disease factors., 12 maart 2024, 10 p.

Diverse species of lactic acid bacteria (LAB) are involved in the spontaneous fermentation of lait caillé, a traditional milk product from Burkina Faso. However, there is little information on the identity of the non-LAB occurring in the fermentation. The objective of this study was to provide information on the identity of non-LAB originating from traditional lait caillé and capable of growing abundantly on standard media used for dairy LAB isolation. Man Rogosa Sharp (MRS) and M17 agar plates previously inoculated with traditional lait caillé were used to screen for gram-negative (catalase-positive or -negative) and gram-positive catalase-positive bacteria. Pure colonies were selected, then the penta-GTG oligonucleotide (GTG)5-based rep-PCR fingerprinting followed by cluster analysis and sequencing of the 16S rRNA gene was performed to identify the isolates. These data will provide key information on the presence of bacteria associated with emerging public health risks. In addition, they may provide insights for a broader investigation of non-LAB occurring in the fermentation of unpasteurized milk and for selective media development.

We introduce LightIt, a method for explicit illumination control for image generation. Recent generative methods lack lighting control, which is crucial to numerous artistic aspects of image generation such as setting the overall mood or cinematic appearance. To overcome these limitations, we propose to condition the generation on shading and normal maps. We model the lighting with single bounce shading, which includes cast shadows. We first train a shading estimation module to generate a dataset of real-world images and shading pairs. Then, we train a control network using the estimated shading and normals as input. Our method demonstrates high-quality image generation and lighting control in numerous scenes. Additionally, we use our generated dataset to train an identity-preserving relighting model, conditioned on an image and a target shading. Our method is the first that enables the generation of images with controllable, consistent lighting and performs on par with specialized relighting state-of-the-art methods., Comment: Project page: https://peter-kocsis.github.io/LightIt/ Video: https://youtu.be/cCfSBD5aPLI

Bayesian inference for complex models with an intractable likelihood can be tackled using algorithms performing many calls to computer simulators. These approaches are collectively known as "simulation-based inference" (SBI). Recent SBI methods have made use of neural networks (NN) to provide approximate, yet expressive constructs for the unavailable likelihood function and the posterior distribution. However, they do not generally achieve an optimal trade-off between accuracy and computational demand. In this work, we propose an alternative that provides both approximations to the likelihood and the posterior distribution, using structured mixtures of probability distributions. Our approach produces accurate posterior inference when compared to state-of-the-art NN-based SBI methods, while exhibiting a much smaller computational footprint. We illustrate our results on several benchmark models from the SBI literature., Comment: 60 pages, 55 figures: the only difference with v1 is a different formatting/LaTeX stylefile

Understanding the lattice dynamics and heat transport physics in the lead-free halide double perovskites remains an outstanding challenge due to their lattice dynamical instability and strong anharmonicity. In this work, we investigate the microscopic mechanisms of anharmonic lattice dynamics and thermal transport in lead-free halide double perovskite Cs2AgBiBr6 from first principles. We combine self-consistent phonon calculations with bubble diagram correction and a unified theory of lattice thermal transport that considers both the particle-like phonon propagation and wave-like tunnelling of phonons. An ultra-low thermal conductivity at room temperature (similar to 0.21 Wm(-1)K(-1)) is predicted with weak temperature dependence( similar to T-0.34), in sharp contrast to the conventional similar to T-1 dependence. Particularly, the vibrational properties of Cs2AgBiBr6 are featured by strong anharmonicity and wave-like tunnelling of phonons. Anharmonic phonon renormalization from both the cubic and quartic anharmonicities are found essential in precisely predicting the phase transition temperature in Cs2AgBiBr6 while the negative phonon energy shifts induced by cubic anharmonicity has a significant influence on particle-like phonon propagation. Further, the contribution of the wave-like tunnelling to the total thermal conductivity surpasses that of the particle-like propagation above around 310 K, indicating the breakdown of the phonon gas picture conventionally used in the Peierls-Boltzmann Transport Equation. Importantly, further including four-phonon scatterings is required in achieving the dominance of wave-like tunnelling, as compared to the dominant particle-like propagation channel when considering only three-phonon scatterings. Our work highlights the importance of lattice anharmonicity and wave-like tunnelling of phonons in the thermal transport in lead-free halide double perovskites.

Isolating the desired speaker's voice amidst multiplespeakers in a noisy acoustic context is a challenging task. Per-sonalized speech enhancement (PSE) endeavours to achievethis by leveraging prior knowledge of the speaker's voice.Recent research efforts have yielded promising PSE mod-els, albeit often accompanied by computationally intensivearchitectures, unsuitable for resource-constrained embeddeddevices. In this paper, we introduce a novel method to per-sonalize a lightweight dual-stage Speech Enhancement (SE)model and implement it within DeepFilterNet2, a SE modelrenowned for its state-of-the-art performance. We seek anoptimal integration of speaker information within the model,exploring different positions for the integration of the speakerembeddings within the dual-stage enhancement architec-ture. We also investigate a tailored training strategy whenadapting DeepFilterNet2 to a PSE task. We show that ourpersonalization method greatly improves the performancesof DeepFilterNet2 while preserving minimal computationaloverhead., Comment: Accepted at HSCMA24, Satellite workshop of ICASSP24

This paper addresses the problem of self-supervised general-purpose audio representation learning. We explore the use of Joint-Embedding Predictive Architectures (JEPA) for this task, which consists of splitting an input mel-spectrogram into two parts (context and target), computing neural representations for each, and training the neural network to predict the target representations from the context representations. We investigate several design choices within this framework and study their influence through extensive experiments by evaluating our models on various audio classification benchmarks, including environmental sounds, speech and music downstream tasks. We focus notably on which part of the input data is used as context or target and show experimentally that it significantly impacts the model's quality. In particular, we notice that some effective design choices in the image domain lead to poor performance on audio, thus highlighting major differences between these two modalities., Comment: Self-supervision in Audio, Speech and Beyond workshop, IEEE International Conference on Acoustics, Speech, and Signal Processing, 2024

We study the connection between mixing properties for bipartite graphs and materialization of the mutual information in one-shot settings. We show that mixing properties of a graph imply impossibility to extract the mutual information shared by the ends of an edge randomly sampled in the graph. We apply these impossibility results to some questions motivated by information-theoretic cryptography. In particular, we show that communication complexity of a secret key agreement in one-shot setting is inherently uneven: for some inputs, almost all communication complexity inevitably falls on only one party., Comment: 16 pages, 4 figures

The three areas of realistic forward rendering, per-pixel inverse rendering, and generative image synthesis may seem like separate and unrelated sub-fields of graphics and vision. However, recent work has demonstrated improved estimation of per-pixel intrinsic channels (albedo, roughness, metallicity) based on a diffusion architecture; we call this the RGB$\rightarrow$X problem. We further show that the reverse problem of synthesizing realistic images given intrinsic channels, X$\rightarrow$RGB, can also be addressed in a diffusion framework. Focusing on the image domain of interior scenes, we introduce an improved diffusion model for RGB$\rightarrow$X, which also estimates lighting, as well as the first diffusion X$\rightarrow$RGB model capable of synthesizing realistic images from (full or partial) intrinsic channels. Our X$\rightarrow$RGB model explores a middle ground between traditional rendering and generative models: we can specify only certain appearance properties that should be followed, and give freedom to the model to hallucinate a plausible version of the rest. This flexibility makes it possible to use a mix of heterogeneous training datasets, which differ in the available channels. We use multiple existing datasets and extend them with our own synthetic and real data, resulting in a model capable of extracting scene properties better than previous work and of generating highly realistic images of interior scenes.

Ces vingt dernières années ont été marquées par des évolutions importantes dans le domaine des troubles bipolaires. La compréhension de la maladie, son repérage et les outils thérapeutiques médicamenteux et non médicamenteux se sont considérablement améliorés et diversifiés.Il est déterminant que les personnes touchées par cette maladie s’impliquent dans l’élaboration de leur propre programme thérapeutique. Ceci nécessite qu’elles se « forment » à la maladie et aux outils qui permettent de la stabiliser.Cet ouvrage s’inscrit dans cette démarche visant à mettre à la disposition des patients et de leurs proches, les explications nécessaires à la compréhension du modèle médical appliqué aux troubles bipolaires. Ce parti pris vise également à modifier les représentations de la maladie et de ses traitements.Conçu autour des questions qui reviennent le plus souvent au cours des consultations, voilà une boite à outils simple à utiliser, qui permettra de mieux comprendre et donc de mieux agir.

We present a novel method for the morphometric analysis of series of 3D shapes, and demonstrate its relevance for the detection and quantification of two craniofacial anomalies: trigonocephaly and metopic ridges, using CT-scans of young children. Our approach is fully automatic, and does not rely on manual landmark placement and annotations. Our approach furthermore allows to differentiate shape classes, enabling successful differential diagnosis between trigonocephaly and metopic ridges, two related conditions characterized by triangular foreheads. These results were obtained using recent developments in automatic nonrigid 3D shape correspondence methods and specifically spectral approaches based on the functional map framework. Our method can capture local changes in geometric structure, in contrast to methods based, for instance, on global shape descriptors. As such, our approach allows to perform automatic shape classification and provides visual feedback on shape regions associated with different classes of deformations. The flexibility and generality of our approach paves the way for the application of spectral methods in quantitative medicine.

Insomnia and its opposite hypersomnia are part of the diagnostic criteria for major depressive disorder (MDD). However, no study has investigated whether the postulated sleep alterations in clinical subtypes of MDD are reflected in polysomnography (PSG)-derived objective sleep measures. The objective of this study was to establish associations between the melancholic, atypical and unspecified subtypes of MDD and objective PSG-based sleep features. This cross-sectional analysis included 1820 community-dwelling individuals who underwent PSG and a semi-structured psychiatric interview to elicit diagnostic criteria for MDD and its subtypes. Adjusted robust linear regression was used to assess associations between MDD subtypes and PSG-derived objective sleep measures. Current melancholic MDD was significantly associated with decreased absolute delta power and sleep efficiency and with increased wake after sleep onset. Remitted unspecified MDD was significantly associated with increased rapid eye movements density. No other significant associations were identified. Our findings reflect that some PSG-based sleep features differed in MDD subtypes compared with no MDD. The largest number of significant differences were observed for current melancholic MDD, whereas only rapid eye movements density could represent a risk factor for MDD as it was the only sleep measure that was also associated with MDD in remitted participants.

The autocovariance of the semidiurnal internal tide (IT) is examined in a 32 d segment of a global run of the HYbrid Coordinate Ocean Model (HYCOM). This numerical simulation, with 41 vertical layers and ∘ horizontal resolution, includes tidal and atmospheric forcing, allowing for the generation and propagation of ITs to take place within a realistic eddying general circulation. The HYCOM data are in turn compared with global observations of the IT around 1000 dbar, from Argo float park-phase data and mooring records. HYCOM is found to be globally biased low in terms of the IT variance and decay of the IT autocovariance over timescales shorter than 32 d. Except in the Southern Ocean, where limitations in the model cause the discrepancy with in situ measurements to grow poleward, the spatial correlation between the Argo and HYCOM tidal variance suggests that the generation of low-mode semidiurnal ITs is globally well captured by the model.