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3 results on '"Gay, Hannah"'

1. Studies of phosphorescence and energy transfer between triplet states in aromatic hydrocarbons

Author

Gay, Hannah, Mason, R., and Evans, D. F.

Subjects
547
Abstract

Phosphorescence decay studios on aromatic hydro-carbons dissolved in rigid matrices have been carried out. Phosphorescence lifetimes of deuterated hydrocarbons are given. The effects of the presence of oxygen and of changes in temperature and solvent on the phosphorescence life-times and intensities have been investigated. It is shown that oxygen has a considerable effect in reducing the lifetimes and intensities, even when the hydrocarbons are dissolved in rigid matrices. The role of rigid media in allowing phosphorescence to be observed is discussed and it is concluded that the rigidity or degree of polymerisation does not affect first order phosphorescence decay; rather it is the permeability of the medium to oxygen and other impurities that is of importance. Glasses of low permeability have been investigated and shown to be efficient media for the study of phosphorescence. There is some evidence to show that phosphorescence is temperature dependent. Activation energies for internal conversion from the lowest triplet to the ground state have been determined; these arc found to be much smaller than those earlier reported. Energy transfer between triplet states has been studied. A slow transfer mechanism, not previously recorded, has bean demonstrated. The nature of this transfer is discussed and a mechanism proposed.

Published
1964

2. Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy

Author

McManus, Margaret, McManus, Margaret, Henderson, Jennifer, Gautam, Anita, Brody, Robin, Weiss, Eric R, Persaud, Deborah, Mick, Eric, Luzuriaga, Katherine, Gay, Hannah, Borkowsky, William, van Dyke, Russell, Stechenberg, Barbara, McIntosh, Kenneth, Farley, John, Pelton, Stephen, Petru, Ann, Spector, Stephen, Bonagura, Vincent, Cunningham, Coleen, Deveikis, Audra, Ruff, Andrea, Shearer, William, McKinney, Ross, Bakshi, Saroj, Rubio, Thomas, Rich, Kenneth, Gaur, Sunanda, Johnson, George, Rana, Sohail, Sleasman, John, Febo, Irma, McManus, Margaret, McManus, Margaret, Henderson, Jennifer, Gautam, Anita, Brody, Robin, Weiss, Eric R, Persaud, Deborah, Mick, Eric, Luzuriaga, Katherine, Gay, Hannah, Borkowsky, William, van Dyke, Russell, Stechenberg, Barbara, McIntosh, Kenneth, Farley, John, Pelton, Stephen, Petru, Ann, Spector, Stephen, Bonagura, Vincent, Cunningham, Coleen, Deveikis, Audra, Ruff, Andrea, Shearer, William, McKinney, Ross, Bakshi, Saroj, Rubio, Thomas, Rich, Kenneth, Gaur, Sunanda, Johnson, George, Rana, Sohail, Sleasman, John, and Febo, Irma

Abstract

BackgroundThis study measured serial plasma human immunodeficiency virus (HIV)-1-specific antibody (Ab) levels in children who initiated antiretroviral therapy (ART) prior to 2 years of age, and evaluated their relationship to peripheral blood HIV-1 RNA and DNA levels.MethodsWe studied 46 HIV-1-infected children, stratified by age at ART initiation (<3 mo, early therapy [ET]; >3 mo-2 years, late therapy [LT]) and by virologic response (R) or non-response (NR), before and up to 4 years following ART. We studied 20 HIV-1-uninfected children born to HIV-1-infected mothers (seroreverters [SR]) as controls. Plasma immunoglobulin G (IgG) Ab levels directed against HIV-1 envelope (gp160, gp41), gag (capsid, p24; matrix, p17), reverse transcriptase (p66/51), and integrase (p31) were serially measured using quantitative enzyme-linked immunosorbent assays. HIV-1 Ab rates of decline were estimated over the first 15 months of the study.ResultsThe HIV-1 Ab rates of decline in the ET-R group were similar to those in the SR group for all Ab specificities, except for p17 (P = .01). Ab decline rates in the LT-R group and the NR group were significantly slower than in the SR group for all tested Ab specificities. After 1 year of age, Ab levels to p31 and p17 were significantly associated with HIV-1 RNA levels (P < .001); Ab levels to gp160 (P < .001) and gp41 (P < .001) were significantly associated with cell-associated HIV-1 DNA levels.ConclusionsQuantitative HIV-1-specific Ab levels may be useful for screening children on ART for viral suppression or for residual, cell-associated HIV-1 DNA levels.Clinical trials registrationNCT00000872.

Published
2019

3. Absence of detectable HIV-1 viremia after treatment cessation in an infant.

Author

Persaud, Deborah, Persaud, Deborah, Gay, Hannah, Ziemniak, Carrie, Chen, Ya Hui, Piatak, Michael, Chun, Tae-Wook, Strain, Matthew, Richman, Douglas, Luzuriaga, Katherine, Persaud, Deborah, Persaud, Deborah, Gay, Hannah, Ziemniak, Carrie, Chen, Ya Hui, Piatak, Michael, Chun, Tae-Wook, Strain, Matthew, Richman, Douglas, and Luzuriaga, Katherine

Abstract

An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.

Published
2013

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