33 results on '"Gabriel, Sherine"'
Search Results
2. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
- Full Text
- View/download PDF
3. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations : evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., Semb, Anne Grete, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
- Full Text
- View/download PDF
4. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
- Full Text
- View/download PDF
5. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
- Full Text
- View/download PDF
6. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations : evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., Semb, Anne Grete, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
- Full Text
- View/download PDF
7. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations : evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., Semb, Anne Grete, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
- Full Text
- View/download PDF
8. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations : evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., Semb, Anne Grete, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
- Full Text
- View/download PDF
9. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients.
- Author
-
Roelsgaard, Ida K, Roelsgaard, Ida K, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A, Kitas, George D, van Riel, Piet, Gabriel, Sherine, Kvien, Tore K, Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A, Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P, González-Gay, Miguel A, Crowson, Cynthia S, Semb, Anne Grete, Roelsgaard, Ida K, Roelsgaard, Ida K, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A, Kitas, George D, van Riel, Piet, Gabriel, Sherine, Kvien, Tore K, Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A, Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P, González-Gay, Miguel A, Crowson, Cynthia S, and Semb, Anne Grete
- Abstract
ObjectivesSmoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients.MethodsDisease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status.ResultsOf the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable.ConclusionSmoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
10. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models.
- Author
-
Wibetoe, Grunde, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D, van Riel, Piet, Gabriel, Sherine, Kvien, Tore K, Douglas, Karen, Sandoo, Aamer, Arts, Elke E, Wållberg-Jonsson, Solveig, Dahlqvist, Solbritt Rantapää, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A, Pascual-Ramos, Virginia, Contreas-Yañes, Irazu, Sfikakis, Petros P, González-Gay, Miguel A, Colunga-Pedraz, Iris J, Galarza-Delgado, Dionicio A, Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S, Semb, Anne Grete, Wibetoe, Grunde, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D, van Riel, Piet, Gabriel, Sherine, Kvien, Tore K, Douglas, Karen, Sandoo, Aamer, Arts, Elke E, Wållberg-Jonsson, Solveig, Dahlqvist, Solbritt Rantapää, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A, Pascual-Ramos, Virginia, Contreas-Yañes, Irazu, Sfikakis, Petros P, González-Gay, Miguel A, Colunga-Pedraz, Iris J, Galarza-Delgado, Dionicio A, Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S, and Semb, Anne Grete
- Abstract
BackgroundIn younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics.MethodsRA patients aged 30-70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up.ResultsA total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15-32% of patients. C-statistics ranged 0.68-0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results.ConclusionsThe cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
11. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., Grete Semb, Anne, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., and Grete Semb, Anne
- Abstract
Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
12. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., Grete Semb, Anne, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., and Grete Semb, Anne
- Abstract
Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
13. Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial
- Author
-
Giles, Jon T, Sattar, Naveed, Gabriel, Sherine, Ridker, Paul M, Gay, Steffen, Warne, Charles, Musselman, David, Brockwell, Laura, Shittu, Emma, Klearman, Micki, Fleming, Thomas R, Giles, Jon T, Sattar, Naveed, Gabriel, Sherine, Ridker, Paul M, Gay, Steffen, Warne, Charles, Musselman, David, Brockwell, Laura, Shittu, Emma, Klearman, Micki, and Fleming, Thomas R
- Abstract
To compare the risk for major adverse cardiovascular events (MACE) in RA patients treated with tocilizumab versus the tumor necrosis factor inhibitor etanercept. This randomized, open-label, parallel-group trial enrolled patients with active seropositive RA (N=3080), inadequate responses to conventional synthetic disease-modifying antirheumatic drugs, and at least one cardiovascular risk factor. Patients were randomly assigned 1:1 to open-label tocilizumab 8 mg/kg/month or etanercept 50 mg/week and followed up for an average of 3.2 years. The primary end point was comparison of time-to-first MACE. The trial was powered to exclude a 1.8 or higher relative hazard of MACE for tocilizumab versus etanercept. By week 4, serum low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels were 11.1%, 5.7%, and 13.6% higher, respectively, for patients allocated to tocilizumab compared with etanercept (all P<.001). During follow-up, 83 MACE occurred in the tocilizumab group compared with 78 in the etanercept group. The estimated hazard of MACE for tocilizumab relative to etanercept was 1.05 (95% confidence interval=0.77, 1.43). Result were similar in sensitivity analyses and the on-treatment analysis. Adverse events that occurred more frequently in the tocilizumab group included serious infection and gastrointestinal perforation. The trial, which provides insights into the cardiovascular safety of tocilizumab versus etanercept, excluded a relative risk for MACE of 1.43 or higher. This result should be interpreted in the context of the clinical efficacy and the non-cardiovascular safety of tocilizumab. This article is protected by copyright. All rights reserved.
- Published
- 2020
14. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., Grete Semb, Anne, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., and Grete Semb, Anne
- Abstract
Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
15. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., Grete Semb, Anne, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., Riel, Piet van, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El Gabalawy, Hani, Hitchon, Carol A., Pascual Ramos, Virginia, Contreas Yañes, Irazu, Sfikakis, Petros P., González Gay, Miguel A., Colunga Pedraza, Iris Jazmín, Galarza Delgado, Dionicio Ángel, Azpiri López, José Ramón, Crowson, Cynthia S., and Grete Semb, Anne
- Abstract
Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
16. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
- Full Text
- View/download PDF
17. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations : evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., Semb, Anne Grete, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
- Full Text
- View/download PDF
18. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., Van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P., González-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., Van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P., González-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
19. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., Van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P., González-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., Van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P., González-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
20. Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations : evaluation of concordance across risk age models
- Author
-
Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., Semb, Anne Grete, Wibetoe, Grunde, Sexton, Joseph, Ikdahl, Eirik, Rollefstad, Silvia, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke E., Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreas-Yanes, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Colunga-Pedraz, Iris J., Galarza-Delgado, Dionicio A., Azpiri-Lopez, Jose Ramon, Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
- Published
- 2020
- Full Text
- View/download PDF
21. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
-
Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida K., Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A., Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Abstract
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
- Published
- 2020
- Full Text
- View/download PDF
22. Smoking cessation in patients with RA is associated with reduced CVD event rates and improved lipid profiles and predicts lower RA disease activity
- Author
-
Roelsgaard, Ida Kristiane, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente Appel, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Pascual, Virginia Dr., Contreras-Yanez, Irazu, Sfikakis, Petros, Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida Kristiane, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente Appel, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Pascual, Virginia Dr., Contreras-Yanez, Irazu, Sfikakis, Petros, Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Published
- 2019
- Full Text
- View/download PDF
23. Smoking cessation in patients with RA is associated with reduced CVD event rates and improved lipid profiles and predicts lower RA disease activity
- Author
-
Roelsgaard, Ida Kristiane, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente Appel, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Pascual, Virginia Dr., Contreras-Yanez, Irazu, Sfikakis, Petros, Gonzalez-Gay, Miguel A., Crowson, Cynthia S., Semb, Anne Grete, Roelsgaard, Ida Kristiane, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente Appel, Kitas, George D., van Riel, Piet, Gabriel, Sherine, Kvien, Tore K., Douglas, Karen, Wållberg-Jonsson, Solveig, Rantapää-Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Pascual, Virginia Dr., Contreras-Yanez, Irazu, Sfikakis, Petros, Gonzalez-Gay, Miguel A., Crowson, Cynthia S., and Semb, Anne Grete
- Published
- 2019
- Full Text
- View/download PDF
24. Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
- Author
-
Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., van Riel, Piet L. C. M., Gabriel, Sherine E., Matteson, Eric L., Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Innala, Lena, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Pascual Ramos, Virginia, Contreras Yanez, Irazu, Sfikakis, Petros P., Zampeli, Evangelia, Gonzalez-Gay, Miguel A., Corrales, Alfonso, van de laar, Mart, Vonkeman, Harald E., Meek, Inger, Samb, Anne Grete, Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., van Riel, Piet L. C. M., Gabriel, Sherine E., Matteson, Eric L., Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Innala, Lena, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Pascual Ramos, Virginia, Contreras Yanez, Irazu, Sfikakis, Petros P., Zampeli, Evangelia, Gonzalez-Gay, Miguel A., Corrales, Alfonso, van de laar, Mart, Vonkeman, Harald E., Meek, Inger, and Samb, Anne Grete
- Abstract
Objectives: Patients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD). We aimed to assess the impact of CVD risk factors, including potential sex differences, and RA-specific variables on CVD outcome in a large, international cohort of patients with RA. Methods: In 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. CVD outcomes (myocardial infarction, angina, revascularisation, stroke, peripheral vascular disease and CVD death) were collected using standardised definitions. Results: 5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p<0.001). Among the traditional CVD risk factors, smoking and hypertension had the highest population attributable risk (PAR) overall and among both sexes, followed by total cholesterol. The PAR for Disease Activity Score and for seropositivity were comparable in magnitude to the PAR for lipids. A total of 70% of CVD events were attributable to all CVD risk factors and RA characteristics combined (separately 49% CVD risk factors and 30% RA characteristics). Conclusions: In a large, international cohort of patients with RA, 30% of CVD events were attributable to RA characteristics. This finding indicates that RA characteristics play an important role in efforts to reduce CVD risk among patients with RA.
- Published
- 2018
- Full Text
- View/download PDF
25. Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
- Author
-
Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., Riel, P.L.C.M. van, Gabriel, Sherine E., Arts, E.E.A., Meek, I.L., Samb, Anne Grete, Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., Riel, P.L.C.M. van, Gabriel, Sherine E., Arts, E.E.A., Meek, I.L., and Samb, Anne Grete
- Abstract
Item does not contain fulltext
- Published
- 2018
26. Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
- Author
-
Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., Riel, P.L.C.M. van, Gabriel, Sherine E., Arts, E.E.A., Meek, I.L., Samb, Anne Grete, Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., Riel, P.L.C.M. van, Gabriel, Sherine E., Arts, E.E.A., Meek, I.L., and Samb, Anne Grete
- Abstract
Item does not contain fulltext
- Published
- 2018
27. Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
- Author
-
Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., Riel, P.L.C.M. van, Gabriel, Sherine E., Arts, E.E.A., Meek, I.L., Samb, Anne Grete, Crowson, Cynthia S., Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., Riel, P.L.C.M. van, Gabriel, Sherine E., Arts, E.E.A., Meek, I.L., and Samb, Anne Grete
- Abstract
Item does not contain fulltext
- Published
- 2018
28. Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis.
- Author
-
Crowson, Cynthia S, Crowson, Cynthia S, Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D, van Riel, Piet LCM, Gabriel, Sherine E, Matteson, Eric L, Kvien, Tore K, Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Innala, Lena, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Ramos, Virginia Pascual, Yáñez, Irazú Contreras, Sfikakis, Petros P, Zampeli, Evangelia, Gonzalez-Gay, Miguel A, Corrales, Alfonso, Laar, Mart van de, Vonkeman, Harald E, Meek, Inger, Semb, Anne Grete, A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA), Crowson, Cynthia S, Crowson, Cynthia S, Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D, van Riel, Piet LCM, Gabriel, Sherine E, Matteson, Eric L, Kvien, Tore K, Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Innala, Lena, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Ramos, Virginia Pascual, Yáñez, Irazú Contreras, Sfikakis, Petros P, Zampeli, Evangelia, Gonzalez-Gay, Miguel A, Corrales, Alfonso, Laar, Mart van de, Vonkeman, Harald E, Meek, Inger, Semb, Anne Grete, and A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA)
- Abstract
ObjectivesPatients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD). We aimed to assess the impact of CVD risk factors, including potential sex differences, and RA-specific variables on CVD outcome in a large, international cohort of patients with RA.MethodsIn 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. CVD outcomes (myocardial infarction, angina, revascularisation, stroke, peripheral vascular disease and CVD death) were collected using standardised definitions.Results5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p<0.001). Among the traditional CVD risk factors, smoking and hypertension had the highest population attributable risk (PAR) overall and among both sexes, followed by total cholesterol. The PAR for Disease Activity Score and for seropositivity were comparable in magnitude to the PAR for lipids. A total of 70% of CVD events were attributable to all CVD risk factors and RA characteristics combined (separately 49% CVD risk factors and 30% RA characteristics).ConclusionsIn a large, international cohort of patients with RA, 30% of CVD events were attributable to RA characteristics. This finding indicates that RA characteristics play an important role in efforts to reduce CVD risk among patients with RA.
- Published
- 2018
29. Performance of Cardiovascular Risk Age and Vascular Age Estimations in Predicting Cardiovascular Events in Rheumatoid Arthritis
- Author
-
Wibetoe, Grunde, Crowson, Cynthia S., Sexton, Joseph, Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., van Riel, Piet, Gabriel, Sherine E., Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Zampeli, Evangelia, Angel Gonzalez-Gay, Miguel, Corrales, Alfonso, Colunga-Pedraza, Iris J., Galarza-Delgado, Dionicio A., Ramon Azpiri-Lopez, Jose, Semb, Anne Grete, Wibetoe, Grunde, Crowson, Cynthia S., Sexton, Joseph, Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D., van Riel, Piet, Gabriel, Sherine E., Kvien, Tore K., Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Rantapää Dahlqvist, Solbritt, Karpouzas, George, Dessein, Patrick H., Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A., Pascual-Ramos, Virginia, Contreras-Yanez, Irazu, Sfikakis, Petros P., Zampeli, Evangelia, Angel Gonzalez-Gay, Miguel, Corrales, Alfonso, Colunga-Pedraza, Iris J., Galarza-Delgado, Dionicio A., Ramon Azpiri-Lopez, Jose, and Semb, Anne Grete
- Abstract
Background/Purpose: Rheumatoid arthritis (RA) patients are at high risk of cardiovascular disease (CVD). Risk algorithms for the general population lack precision when applied to RA patients and validated RA-specific CVD prediction models are missing. Risk age estimations are recommended as adjuncts to assessment of absolute 10-year risk of fatal CVD events. Two risk age models based on the Systematic Coronary Risk Evaluation (SCORE) algorithm have been developed; the cardiovascular risk age and the vascular age. However, the performance of these models has not been compared. Using longitudinal data on CVD events in RA patients, we aimed to compare the discriminative ability of cardiovascular risk age and vascular age among RA patients and in subgroups of RA patients based on disease characteristics. Methods: Patients with RA were included from an international consortium, aged 30-70 years at baseline. Those with prior CVD, diabetes and/or users of lipid-lowering and/or antihypertensive therapy at baseline were excluded. Cardiovascular risk age was estimated based on chronologic age, smoking status, total cholesterol and systolic blood pressure at baseline. Vascular age was derived from the 10-year risk of CVD according to the SCORE algorithm, with or without high density lipoprotein cholesterol, using the equations for low and high risk countries. Performance of each risk age model in predicting CVD events was assessed using the concordance index. Results: Among the1867 RA patients included, 74% were female, median (inter-quartile range) age and disease duration were 52.0 (44.0, 59.9) and 0.6 (0.1, 6.4) years, 72.5% were rheumatoid factor positive, 24.7% were using glucocorticoids and 10.3% were using biologics at baseline. Overall, 144 CVD events occurred and median follow-up time was 5.0 (2.6, 9.3) years. Median difference between estimated risk age and chronologic age was 4.0 to 6.7 years, depending on the specific risk age model applied. Overall, the C-index ac, Supplement: 10Meeting Abstract: 147
- Published
- 2017
30. Rheumatoid arthritis-specific cardiovascular risk scores are not superior to general risk scores: a validation analysis of patients from seven countries.
- Author
-
Crowson, Cynthia S, Crowson, Cynthia S, Gabriel, Sherine E, Semb, Anne Grete, van Riel, Piet LCM, Karpouzas, George, Dessein, Patrick H, Hitchon, Carol, Pascual-Ramos, Virginia, Kitas, George D, Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis, Crowson, Cynthia S, Crowson, Cynthia S, Gabriel, Sherine E, Semb, Anne Grete, van Riel, Piet LCM, Karpouzas, George, Dessein, Patrick H, Hitchon, Carol, Pascual-Ramos, Virginia, Kitas, George D, and Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis
- Abstract
ObjectivesCardiovascular disease (CVD) risk calculators developed for the general population do not accurately predict CVD events in patients with RA. We sought to externally validate risk calculators recommended for use in patients with RA including the EULAR 1.5 multiplier, the Expanded Cardiovascular Risk Prediction Score for RA (ERS-RA) and QRISK2.MethodsSeven RA cohorts from UK, Norway, Netherlands, USA, South Africa, Canada and Mexico were combined. Data on baseline CVD risk factors, RA characteristics and CVD outcomes (including myocardial infarction, ischaemic stroke and cardiovascular death) were collected using standardized definitions. Performance of QRISK2, EULAR multiplier and ERS-RA was compared with other risk calculators [American College of Cardiology/American Heart Association (ACC/AHA), Framingham Adult Treatment Panel III Framingham risk score-Adult Treatment Panel (FRS-ATP) and Reynolds Risk Score] using c-statistics and net reclassification index.ResultsAmong 1796 RA patients without prior CVD [mean ( s . d .) age: 54.0 (14.0) years, 74% female], 100 developed CVD events during a mean follow-up of 6.9 years (12430 person-years). Estimated CVD risk by ERS-RA [mean ( s . d .) 8.8% (9.8%)] was comparable to FRS-ATP [mean ( s . d .) 9.1% (8.3%)] and Reynolds [mean ( s . d .) 9.2% (12.2%)], but lower than ACC/AHA [mean ( s . d .) 9.8% (12.1%)]. QRISK2 substantially overestimated risk [mean ( s . d .) 15.5% (13.9%)]. Discrimination was not improved for ERS-RA (c-statistic = 0.69), QRISK2 or EULAR multiplier applied to ACC/AHA compared with ACC/AHA (c-statistic = 0.72 for all) or for FRS-ATP (c-statistic = 0.75). The net reclassification index for ERS-RA was low (-0.8% vs ACC/AHA and 2.3% vs FRS-ATP).ConclusionThe QRISK2, EULAR multiplier and ERS-RA algorithms did not predict CVD risk more accurately in patients with RA than CVD risk calculators developed for the general population.
- Published
- 2017
31. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors.
- Author
-
Murray, Christopher JL, Murray, Christopher JL, Atkinson, Charles, Bhalla, Kavi, Birbeck, Gretchen, Burstein, Roy, Chou, David, Dellavalle, Robert, Danaei, Goodarz, Ezzati, Majid, Fahimi, A, Flaxman, D, Foreman, Gabriel, Sherine, Gakidou, Emmanuela, Kassebaum, Nicholas, Khatibzadeh, Shahab, Lim, Stephen, Lipshultz, Steven E, London, Stephanie, Lopez, MacIntyre, Michael F, Mokdad, AH, Moran, A, Moran, Andrew E, Mozaffarian, Dariush, Murphy, Tasha, Naghavi, Moshen, Pope, C, Roberts, Thomas, Salomon, Joshua, Schwebel, David C, Shahraz, Saeid, Sleet, David A, Murray, Abraham, Jerry, Ali, Mohammed K, Bartels, David H, Chen, Honglei, Criqui, Michael H, Dahodwala, Jarlais, Ding, Eric L, Dorsey, E Ray, Ebel, Beth E, Fahami, Flaxman, S, Flaxman, AD, Gonzalez-Medina, Diego, Grant, Bridget, Hagan, Holly, Hoffman, Howard, Leasher, Janet L, Lin, John, Lozano, Rafael, Lu, Yuan, Mallinger, Leslie, McDermott, Mary M, Micha, Renata, Miller, Ted R, Mokdad, AA, Naghavi, Mohsen, Narayan, KM Venkat, Omer, Saad B, Pelizzari, Pamela M, Phillips, David, Ranganathan, Dharani, Rivara, Frederick P, Sampson, Uchechukwu, Sanman, Ella, Sapkota, Amir, Sharaz, Saeid, Shivakoti, Rupak, Singh, Gitanjali M, Singh, David, Tavakkoli, Mohammad, Towbin, Jeffrey A, Wilkinson, James D, Zabetian, Azadeh, Ali, Mohammad K, Alvardo, Miriam, Baddour, Larry M, Benjamin, Emelia J, Bolliger, Ian, Murray, Christopher JL, Murray, Christopher JL, Atkinson, Charles, Bhalla, Kavi, Birbeck, Gretchen, Burstein, Roy, Chou, David, Dellavalle, Robert, Danaei, Goodarz, Ezzati, Majid, Fahimi, A, Flaxman, D, Foreman, Gabriel, Sherine, Gakidou, Emmanuela, Kassebaum, Nicholas, Khatibzadeh, Shahab, Lim, Stephen, Lipshultz, Steven E, London, Stephanie, Lopez, MacIntyre, Michael F, Mokdad, AH, Moran, A, Moran, Andrew E, Mozaffarian, Dariush, Murphy, Tasha, Naghavi, Moshen, Pope, C, Roberts, Thomas, Salomon, Joshua, Schwebel, David C, Shahraz, Saeid, Sleet, David A, Murray, Abraham, Jerry, Ali, Mohammed K, Bartels, David H, Chen, Honglei, Criqui, Michael H, Dahodwala, Jarlais, Ding, Eric L, Dorsey, E Ray, Ebel, Beth E, Fahami, Flaxman, S, Flaxman, AD, Gonzalez-Medina, Diego, Grant, Bridget, Hagan, Holly, Hoffman, Howard, Leasher, Janet L, Lin, John, Lozano, Rafael, Lu, Yuan, Mallinger, Leslie, McDermott, Mary M, Micha, Renata, Miller, Ted R, Mokdad, AA, Naghavi, Mohsen, Narayan, KM Venkat, Omer, Saad B, Pelizzari, Pamela M, Phillips, David, Ranganathan, Dharani, Rivara, Frederick P, Sampson, Uchechukwu, Sanman, Ella, Sapkota, Amir, Sharaz, Saeid, Shivakoti, Rupak, Singh, Gitanjali M, Singh, David, Tavakkoli, Mohammad, Towbin, Jeffrey A, Wilkinson, James D, Zabetian, Azadeh, Ali, Mohammad K, Alvardo, Miriam, Baddour, Larry M, Benjamin, Emelia J, and Bolliger, Ian
- Abstract
ImportanceUnderstanding the major health problems in the United States and how they are changing over time is critical for informing national health policy.ObjectivesTo measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with those of the 34 countries in the Organisation for Economic Co-operation and Development (OECD) countries.DesignWe used the systematic analysis of descriptive epidemiology of 291 diseases and injuries, 1160 sequelae of these diseases and injuries, and 67 risk factors or clusters of risk factors from 1990 to 2010 for 187 countries developed for the Global Burden of Disease 2010 Study to describe the health status of the United States and to compare US health outcomes with those of 34 OECD countries. Years of life lost due to premature mortality (YLLs) were computed by multiplying the number of deaths at each age by a reference life expectancy at that age. Years lived with disability (YLDs) were calculated by multiplying prevalence (based on systematic reviews) by the disability weight (based on population-based surveys) for each sequela; disability in this study refers to any short- or long-term loss of health. Disability-adjusted life-years (DALYs) were estimated as the sum of YLDs and YLLs. Deaths and DALYs related to risk factors were based on systematic reviews and meta-analyses of exposure data and relative risks for risk-outcome pairs. Healthy life expectancy (HALE) was used to summarize overall population health, accounting for both length of life and levels of ill health experienced at different ages.ResultsUS life expectancy for both sexes combined increased from 75.2 years in 1990 to 78.2 years in 2010; during the same period, HALE increased from 65.8 years to 68.1 years. The diseases and injuries with the largest number of YLLs in 2010 were ischemic heart disease, lung cancer, stroke, chronic obstructive pulmonary disease, and road injury. Age-stand
- Published
- 2013
32. 2006 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN).
- Author
-
Khan, Muhammad Asim, Clegg, Daniel O, Deodhar, Atul A, Gabriel, Sherine, Gaston, J S Hill, Hirsch, Rosemarie, Reveille, John D, Turkiewicz, Anthony M, Østergaard, Mikkel, Weisman, Michael H, Davis, John C, NN, NN, Khan, Muhammad Asim, Clegg, Daniel O, Deodhar, Atul A, Gabriel, Sherine, Gaston, J S Hill, Hirsch, Rosemarie, Reveille, John D, Turkiewicz, Anthony M, Østergaard, Mikkel, Weisman, Michael H, Davis, John C, and NN, NN
- Abstract
Udgivelsesdato: 2007-May, No abstract available
- Published
- 2007
33. 2006 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN).
- Author
-
Khan, Muhammad Asim, Clegg, Daniel O, Deodhar, Atul A, Gabriel, Sherine, Gaston, J S Hill, Hirsch, Rosemarie, Reveille, John D, Turkiewicz, Anthony M, Østergaard, Mikkel, Weisman, Michael H, Davis, John C, NN, NN, Khan, Muhammad Asim, Clegg, Daniel O, Deodhar, Atul A, Gabriel, Sherine, Gaston, J S Hill, Hirsch, Rosemarie, Reveille, John D, Turkiewicz, Anthony M, Østergaard, Mikkel, Weisman, Michael H, Davis, John C, and NN, NN
- Abstract
Udgivelsesdato: 2007-May, No abstract available
- Published
- 2007
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.