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In this article, we proposed some influence diagnostics for the gamma regression model (GRM) and the gamma ridge regression model (GRRM). We assess the impact of influential observations on the GRM and GRRM estimates by extending the work of Pregibon [Logistic regression diagnostics. Ann Stat. 1981;9:705–724] and Walker and Birch [Influence measures in ridge regression. Technometrics. 1988;30:221–227]. Comparison of both models is made and demonstrated with the help of a simulation study and a real data set. We report some momentous results in detecting the influential observations and their effects on the GRM and GRRM estimates.

This paper looks at the research proceedings at EMS (Electronmusikstudion) in Stockholm during the end of the 1960s, under the leadership of Knut Wiggen, and studies his interactions with Pierre Schaeffer in order to establish a new compositional technique for electroacoustic music. The first part deals with the examination of their research method of proposing a sort of compositional and technical program that led the main scientific and creative directions of GRM (Groupe de Recherches Musicales) and EMS. The second part attempts to demonstrate how Wiggen intended to make operational Schaeffer’s sound description system by means of his hybrid studio apparatus. Lastly, the study focuses on how Wiggen’s project differed from the Schaefferian model as well as from GRM after the installation of a computer-controlled studio in 1970 with the development of Musicbox and EMS-1 programs. Hence, this investigation allows us to observe the evolution of technology at EMS in relation to GRM as well as to contrast those developments with Schaeffer’s and Wiggen’s purposes.The historical background of the technical equipment is aimed mainly at musicians and musicologists. It points out the operational features of the apparatus that are useful for an in-depth understanding of composition technique based on Schaeffer’s and Wiggen’s approaches.

Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unaltered. However, close examination of the literature suggests that these findings are superficial, and in actuality, a number of critical factors have not yet been considered; alterations may be highly dependent on brain region, neuronal population or molecular organisation in specific cellular compartments. A number of genetic knockout studies (mGluR5, Norbin, Homer1 etc.) continue to lend support to a role of mGluR5 in the pathology of schizophrenia, providing impetus to explore the regulation of mGluR5 beyond total mGluR5 protein and mRNA levels. With regards to major depression, preliminary evidence to date shows a reduction in total mGluR5 protein and mRNA levels; however, as in schizophrenia, there are no studies examining mGluR5 function or regulation in the pathological state. A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders. Summary Despite the complexities, examinations of post-mortem human brain provide valuable insights into the pathologies of these inherently human disorders. It is important, especially with regards to the identification of novel therapeutic drug targets, to have an in depth understanding of the pathophysiologies of these disorders. We posit that brain region- and cell type-specific alterations exist in mGluR5 in schizophrenia and depression, with evidence pointing towards altered regulation of

Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unaltered. However, close examination of the literature suggests that these findings are superficial, and in actuality, a number of critical factors have not yet been considered; alterations may be highly dependent on brain region, neuronal population or molecular organisation in specific cellular compartments. A number of genetic knockout studies (mGluR5, Norbin, Homer1 etc.) continue to lend support to a role of mGluR5 in the pathology of schizophrenia, providing impetus to explore the regulation of mGluR5 beyond total mGluR5 protein and mRNA levels. With regards to major depression, preliminary evidence to date shows a reduction in total mGluR5 protein and mRNA levels; however, as in schizophrenia, there are no studies examining mGluR5 function or regulation in the pathological state. A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders. Summary Despite the complexities, examinations of post-mortem human brain provide valuable insights into the pathologies of these inherently human disorders. It is important, especially with regards to the identification of novel therapeutic drug targets, to have an in depth understanding of the pathophysiologies of these disorders. We posit that brain region- and cell type-specific alterations exist in mGluR5 in schizophrenia and depression, with evidence pointing towards altered regulation of

Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unaltered. However, close examination of the literature suggests that these findings are superficial, and in actuality, a number of critical factors have not yet been considered; alterations may be highly dependent on brain region, neuronal population or molecular organisation in specific cellular compartments. A number of genetic knockout studies (mGluR5, Norbin, Homer1 etc.) continue to lend support to a role of mGluR5 in the pathology of schizophrenia, providing impetus to explore the regulation of mGluR5 beyond total mGluR5 protein and mRNA levels. With regards to major depression, preliminary evidence to date shows a reduction in total mGluR5 protein and mRNA levels; however, as in schizophrenia, there are no studies examining mGluR5 function or regulation in the pathological state. A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders. Summary Despite the complexities, examinations of post-mortem human brain provide valuable insights into the pathologies of these inherently human disorders. It is important, especially with regards to the identification of novel therapeutic drug targets, to have an in depth understanding of the pathophysiologies of these disorders. We posit that brain region- and cell type-specific alterations exist in mGluR5 in schizophrenia and depression, with evidence pointing towards altered regulation of

Kirchenmusik in der Feier der Heiligen Messe nach den liturgischen Bestimmungen der kirchlichen Dokumente von 1900 bis zur Gegenwart, Stefan Plattner, Diplomarbeit Universität Innsbruck 2020

Kirchenmusik in der Feier der Heiligen Messe nach den liturgischen Bestimmungen der kirchlichen Dokumente von 1900 bis zur Gegenwart, Stefan Plattner, Diplomarbeit Universität Innsbruck 2020