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1. Endovascular Thrombectomy Outcomes in Transferred Octogenarians: A Multicenter Pooled Analysis

Author

Greco, Jonathan Chen, Michael Hassan, Ameer E. Goyal, Nitin and Kamal, Haris Blackburn, Spiros Abraham, Michael G. Day, Arthur L. Sitton, Clark Requena, Manuel Grotta, James C. and Elijovich, Lucas Dannenbaum, Mark J. Tekle, Wondwossen Hoit, Daniel Pujara, Deep Shaker, Faris Reddy, Sujan S. Azher, I, Aidan Abdulrazzak, Mohammad Ammar Mir, Osman Parsha, Kaushik N. Martin-schild, Sheryl Tsivgoulis, Georgios K. and Alexandrov, V, Andrei Ribo, Marc Sarraj, Amrou and Greco, Jonathan Chen, Michael Hassan, Ameer E. Goyal, Nitin and Kamal, Haris Blackburn, Spiros Abraham, Michael G. Day, Arthur L. Sitton, Clark Requena, Manuel Grotta, James C. and Elijovich, Lucas Dannenbaum, Mark J. Tekle, Wondwossen Hoit, Daniel Pujara, Deep Shaker, Faris Reddy, Sujan S. Azher, I, Aidan Abdulrazzak, Mohammad Ammar Mir, Osman Parsha, Kaushik N. Martin-schild, Sheryl Tsivgoulis, Georgios K. and Alexandrov, V, Andrei Ribo, Marc Sarraj, Amrou

Published
2021

2. Beyond the “Code”: A Guide to the Description and Documentation of Biodiversity in Ciliated Protists (Alveolata, Ciliophora)

Author

Warren, Alan, Patterson, David J., Dunthorn, Micah, Clamp, John C., Achilles Day, Undine E.M., Aescht, Erna, Al-Farraj, Saleh A., Al-Quraishy, Saleh, Al-Rasheid, Khaled, Carr, Martin, G. Day, John, Dellinger, Marc, El-Serehy, Hamed A., Fan, Yangbo, Gao, Feng, Gao, Shan, Gong, Jun, Gupta, Renu, Hu, Xiaozhong, Kamra, Komal, Langlois, Gaytha, Lin, Xiaofeng, Lipscomb, Diana, Lobban, Christopher S., Luporini, Pierangelo, Lynn, Denis H., Ma, Honggang, Macek, Miroslav, Mackenzie-Dodds, Jacqueline, Makhija, Seema, Mansergh, Robert I., Martín Cereceda, María Mercedes, McMiller, Nettie, Montagnes, David J.S., Nikolaeva, Svetlana, Ong'ondo, Geoffrey Odhiambo, Pérez Uz, María Blanca, Purushothaman, Jasmine, Quintela Alonso, Pablo, Rotterová, Johana, Santoferrara, Luciana, Shao, Chen, Shen, Zhuo, Shi, Xinlu, Song, Weibo, Stoeck, Thorsten, Terza, Antonietta La, Vallesi, Adriana, Wang, Mei, Weisse, Thomas, Wiackowski, Krzysztof, Wu, Lei, Xu, Kuidong, Yi, Zhenzhen, Zufall, Rebecca, Agatha, Sabine, Warren, Alan, Patterson, David J., Dunthorn, Micah, Clamp, John C., Achilles Day, Undine E.M., Aescht, Erna, Al-Farraj, Saleh A., Al-Quraishy, Saleh, Al-Rasheid, Khaled, Carr, Martin, G. Day, John, Dellinger, Marc, El-Serehy, Hamed A., Fan, Yangbo, Gao, Feng, Gao, Shan, Gong, Jun, Gupta, Renu, Hu, Xiaozhong, Kamra, Komal, Langlois, Gaytha, Lin, Xiaofeng, Lipscomb, Diana, Lobban, Christopher S., Luporini, Pierangelo, Lynn, Denis H., Ma, Honggang, Macek, Miroslav, Mackenzie-Dodds, Jacqueline, Makhija, Seema, Mansergh, Robert I., Martín Cereceda, María Mercedes, McMiller, Nettie, Montagnes, David J.S., Nikolaeva, Svetlana, Ong'ondo, Geoffrey Odhiambo, Pérez Uz, María Blanca, Purushothaman, Jasmine, Quintela Alonso, Pablo, Rotterová, Johana, Santoferrara, Luciana, Shao, Chen, Shen, Zhuo, Shi, Xinlu, Song, Weibo, Stoeck, Thorsten, Terza, Antonietta La, Vallesi, Adriana, Wang, Mei, Weisse, Thomas, Wiackowski, Krzysztof, Wu, Lei, Xu, Kuidong, Yi, Zhenzhen, Zufall, Rebecca, and Agatha, Sabine

Abstract

Recent advances in molecular technology have revolutionized research on all aspects of the biology of organisms, including ciliates, and created unprecedented opportunities for pursuing a more integrative approach to investigations of biodiversity. However, this goal is complicated by large gaps and inconsistencies that still exist in the foundation of basic information about biodiversity of ciliates. The present paper reviews issues relating to the taxonomy of ciliates and presents specific recommendations for best practice in the observation and documentation of their biodiversity. This effort stems from a workshop that explored ways to implement six Grand Challenges proposed by the International Research Coordination Network for Biodiversity of Ciliates (IRCN-BC). As part of its commitment to strengthening the knowledge base that supports research on biodiversity of ciliates, the IRCN-BC proposes to populate The Ciliate Guide, an online database, with biodiversity-related data and metadata to create a resource that will facilitate accurate taxonomic identifications and promote sharing of data., U.S. National Science Foundation, National Natural Science Foundation of China, Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub

Published
2017

3. Beyond the “Code”: A Guide to the Description and Documentation of Biodiversity in Ciliated Protists (Alveolata, Ciliophora)

Author

Warren, Alan, Patterson, David J., Dunthorn, Micah, Clamp, John C., Achilles Day, Undine E.M., Aescht, Erna, Al-Farraj, Saleh A., Al-Quraishy, Saleh, Al-Rasheid, Khaled, Carr, Martin, G. Day, John, Dellinger, Marc, El-Serehy, Hamed A., Fan, Yangbo, Gao, Feng, Gao, Shan, Gong, Jun, Gupta, Renu, Hu, Xiaozhong, Kamra, Komal, Langlois, Gaytha, Lin, Xiaofeng, Lipscomb, Diana, Lobban, Christopher S., Luporini, Pierangelo, Lynn, Denis H., Ma, Honggang, Macek, Miroslav, Mackenzie-Dodds, Jacqueline, Makhija, Seema, Mansergh, Robert I., Martín Cereceda, María Mercedes, McMiller, Nettie, Montagnes, David J.S., Nikolaeva, Svetlana, Ong'ondo, Geoffrey Odhiambo, Pérez Uz, María Blanca, Purushothaman, Jasmine, Quintela Alonso, Pablo, Rotterová, Johana, Santoferrara, Luciana, Shao, Chen, Shen, Zhuo, Shi, Xinlu, Song, Weibo, Stoeck, Thorsten, Terza, Antonietta La, Vallesi, Adriana, Wang, Mei, Weisse, Thomas, Wiackowski, Krzysztof, Wu, Lei, Xu, Kuidong, Yi, Zhenzhen, Zufall, Rebecca, Agatha, Sabine, Warren, Alan, Patterson, David J., Dunthorn, Micah, Clamp, John C., Achilles Day, Undine E.M., Aescht, Erna, Al-Farraj, Saleh A., Al-Quraishy, Saleh, Al-Rasheid, Khaled, Carr, Martin, G. Day, John, Dellinger, Marc, El-Serehy, Hamed A., Fan, Yangbo, Gao, Feng, Gao, Shan, Gong, Jun, Gupta, Renu, Hu, Xiaozhong, Kamra, Komal, Langlois, Gaytha, Lin, Xiaofeng, Lipscomb, Diana, Lobban, Christopher S., Luporini, Pierangelo, Lynn, Denis H., Ma, Honggang, Macek, Miroslav, Mackenzie-Dodds, Jacqueline, Makhija, Seema, Mansergh, Robert I., Martín Cereceda, María Mercedes, McMiller, Nettie, Montagnes, David J.S., Nikolaeva, Svetlana, Ong'ondo, Geoffrey Odhiambo, Pérez Uz, María Blanca, Purushothaman, Jasmine, Quintela Alonso, Pablo, Rotterová, Johana, Santoferrara, Luciana, Shao, Chen, Shen, Zhuo, Shi, Xinlu, Song, Weibo, Stoeck, Thorsten, Terza, Antonietta La, Vallesi, Adriana, Wang, Mei, Weisse, Thomas, Wiackowski, Krzysztof, Wu, Lei, Xu, Kuidong, Yi, Zhenzhen, Zufall, Rebecca, and Agatha, Sabine

Abstract

Recent advances in molecular technology have revolutionized research on all aspects of the biology of organisms, including ciliates, and created unprecedented opportunities for pursuing a more integrative approach to investigations of biodiversity. However, this goal is complicated by large gaps and inconsistencies that still exist in the foundation of basic information about biodiversity of ciliates. The present paper reviews issues relating to the taxonomy of ciliates and presents specific recommendations for best practice in the observation and documentation of their biodiversity. This effort stems from a workshop that explored ways to implement six Grand Challenges proposed by the International Research Coordination Network for Biodiversity of Ciliates (IRCN-BC). As part of its commitment to strengthening the knowledge base that supports research on biodiversity of ciliates, the IRCN-BC proposes to populate The Ciliate Guide, an online database, with biodiversity-related data and metadata to create a resource that will facilitate accurate taxonomic identifications and promote sharing of data., U.S. National Science Foundation, National Natural Science Foundation of China, Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub

Published
2017

6. Meat intake and bladder cancer in a prospective study: A role for heterocyclic aromatic amines?

Author

Lumbreras, B. Garte, S. Overvad, K. Tjonneland, A. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Martinez, C. Dorronsoro, M. Barricarte, A. Chirlaque, M.-D. Quiros, J.R. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Malaveille, C. Ferrari, P. Boffetta, P. Norat, T. Riboli, E. Gonzalez, C.A. Vineis, P. and Lumbreras, B. Garte, S. Overvad, K. Tjonneland, A. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Martinez, C. Dorronsoro, M. Barricarte, A. Chirlaque, M.-D. Quiros, J.R. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Malaveille, C. Ferrari, P. Boffetta, P. Norat, T. Riboli, E. Gonzalez, C.A. Vineis, P.

Abstract

Background: The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity. Methods: Data were collected as part of a case-control study nested within the EPIC cohort, the Gen Air investigation. EPIC is a prospective study designed to investigate the relationship between nutrition and cancer. Information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire. The subjects were restricted to non-smokers. We calculated the matched odds ratio for bladder cancer risk using logistic regression, controlling for potential confounders. Results: There were 227 bladder cases and 612 controls matched 1:3. Meat intake and NAT2 genotype were not independently associated with bladder cancer risk. A significant relationship was observed between bladder cancer risk and consumption of meat only among subjects with the rapid NAT2 genotype (odds ratios [OR] 2.9, 95% CI 1.0-7.9 for the 2nd quartile of meat intake; 3.6, 95% CI 1.3-9.7 for the 3rd quartile; and 3.5, 95% CI 1.2-9.7 for the 4th quartile), and was not present among subjects with the slow genotype. An interaction between NAT2 and meat intake was found in logistic regression (P = 0.034). No association was observed for SULT1A*1/2 genotype (1.0; 95% CI 0.7-1.5) and for SULT1A1*2/2 genotype (0.9; 95% CI 0.5-1.7). Conclusions: These results are suggestive of a role of meat intake and NAT2 on bladder cancer risk. They support the hypothesis that among subjects with the rapid NAT2 acetylation genotype higher levels of HAAs exposure are a bladder cancer risk factor. We did not observe an effect of SULT1A1 allele variants on this cancer. The present study adds new information on the possible long-term adverse effects of die

Published
2008

7. Meat intake and bladder cancer in a prospective study: A role for heterocyclic aromatic amines? (Cancer Causes and Control DOI: 10.1007/s10552-008-9121-1)

Author

Lumbreras, B. Garte, S. Overvad, K. Tjonneland, A. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Martinez, C. Dorronsoro, M. Barricarte, A. Chirlaque, M.D. Quiros, J.R. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Malaveille, C. Ferrari, P. Boffetta, P. Norat, T. Riboli, E. Gonzalez, C.A. Vineis, P. and Lumbreras, B. Garte, S. Overvad, K. Tjonneland, A. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Martinez, C. Dorronsoro, M. Barricarte, A. Chirlaque, M.D. Quiros, J.R. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Malaveille, C. Ferrari, P. Boffetta, P. Norat, T. Riboli, E. Gonzalez, C.A. Vineis, P.

Published
2008

8. Amount of DNA in plasma and cancer risk: A prospective study

Author

Gormally, E Hainaut, P Caboux, E Airoldi, L Autrup, H and Malaveille, C Dunning, A Garte, S Matullo, G and Overvad, K Tjonneland, A Clavel-Chapelon, F Boffetta, P and Boeing, H Trichopoulou, A Palli, D Krogh, V Tumino, R and Panico, S Bueno-De-Mesquita, HB Peeters, PH Lund, E and Gonzalez, CA Martinez, C Dorronsoro, M Barricarte, A and Tormo, MJ Quiros, JR Berglund, G Hallmans, G Day, NE and Key, TJ Veglia, F Peluso, M Norat, T Saracci, R and Kaaks, R Riboli, E Vineis, P and Gormally, E Hainaut, P Caboux, E Airoldi, L Autrup, H and Malaveille, C Dunning, A Garte, S Matullo, G and Overvad, K Tjonneland, A Clavel-Chapelon, F Boffetta, P and Boeing, H Trichopoulou, A Palli, D Krogh, V Tumino, R and Panico, S Bueno-De-Mesquita, HB Peeters, PH Lund, E and Gonzalez, CA Martinez, C Dorronsoro, M Barricarte, A and Tormo, MJ Quiros, JR Berglund, G Hallmans, G Day, NE and Key, TJ Veglia, F Peluso, M Norat, T Saracci, R and Kaaks, R Riboli, E Vineis, P

Abstract

Levels of plasma DNA concentrations in cancer patients have been shown to be higher than the plasma DNA concentrations found in healthy subjects. The value of plasma DNA levels for development of neoplastic or pulmonary disease was evaluated in a large prospective study. Plasma samples (n = 1, 184) were analyzed from 776 controls, 359 cases of cancer (lung, bladder, oral cavity, pharynx, larynx, leukemia) and 49 deaths from chronic obstructive pulmonary disease (COPD), including never smokers and ex-smokers, from 9 countries across Europe. The amount of plasma DNA was variable across the European Prospective Investigation into Cancer and Nutrition (EPIC) centers. High DNA concentrations in some centers might be due to the type of population recruited and/or the treatment of the samples. An elevated and statistically significant odds ratio (OR) was found for COPID deaths (OR = 2.53; 95% CI = 1.06-6.02), while nonsignificant increased ORs were present for oral cancers, cancers of the pharynx and larynx and leukemia. When the analyses were stratified by time since recruitment (below or above 36 months), the increased ORs were limited to the more recent period of recruitment, i.e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPID deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% Cl = 1.20-4.67). (C) 2004 Wiley-Liss, Inc.

Published
2004

9. European Prospective Investigation into Cancer and Nutrition (EPIC): Study populations and data collection

Author

Riboli, E. Hunt, K.J. Slimani, N. Ferrari, P. Norat, T. Fahey, M. Charrondière, U.R. Hémon, B. Casagrande, C. Vignat, J. Overvad, K. Tjønneland, A. Clavel-Chapelon, F. Thiébaut, A. Wahrendorf, J. Boeing, H. Trichopoulos, D. Trichopoulou, A. Vineis, P. Palli, D. Bueno-de-Mesquita, H.B. Peeters, P.H.M. Lund, E. Engeset, D. González, C.A. Barricarte, A. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Kaaks, R. Saracci, R. and Riboli, E. Hunt, K.J. Slimani, N. Ferrari, P. Norat, T. Fahey, M. Charrondière, U.R. Hémon, B. Casagrande, C. Vignat, J. Overvad, K. Tjønneland, A. Clavel-Chapelon, F. Thiébaut, A. Wahrendorf, J. Boeing, H. Trichopoulos, D. Trichopoulou, A. Vineis, P. Palli, D. Bueno-de-Mesquita, H.B. Peeters, P.H.M. Lund, E. Engeset, D. González, C.A. Barricarte, A. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Kaaks, R. Saracci, R.

Abstract

The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrolment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.

Published
2002

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